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https://www.readbyqxmd.com/read/28217366/crizotinib-inhibits-hyperpolarization-activated-cyclic-nucleotide-gated-channel-4-activity
#1
Zhushan Zhang, Tai-Qin Huang, Igor Nepliouev, Hengtao Zhang, Adam S Barnett, Paul B Rosenberg, Sai-Hong I Ou, Jonathan A Stiber
BACKGROUND: Sinus bradycardia is frequently observed in patients treated with crizotinib, a receptor tyrosine kinase inhibitor used for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We investigated whether crizotinib could influence heart rate (HR) through direct cardiac effects. METHODS: The direct effect of crizotinib on HR was studied using ECG analysis of Langendorff-perfused mouse hearts. The whole-cell patch clamp technique was used to measure the effects of crizotinib on the hyperpolarization-activated funny current, If, in mouse sinoatrial node cells (SANCs) and hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) activity in HEK-293 cells stably expressing human HCN4...
2017: Cardiooncology
https://www.readbyqxmd.com/read/28185290/computational-analysis-of-the-human-sinus-node-action-potential-model-development-and-effects-of-mutations
#2
Alan Fabbri, Matteo Fantini, Ronald Wilders, Stefano Severi
The sinoatrial node (SAN) is the normal pacemaker of the mammalian heart.  Over several decades, a large amount of data on the ionic mechanisms underlying the spontaneous electrical activity of SAN pacemaker cells has been obtained, mostly in experiments on single cells isolated from rabbit SAN. This wealth of data has allowed the development of mathematical models of the electrical activity of rabbit SAN pacemaker cells. Our aim was to construct a more comprehensive model of the electrical activity of a human SAN pacemaker cell, using recently obtained electrophysiological data from human SAN pacemaker cells...
February 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28141706/attached-to-a-diagnosis-the-quandary-of-social-deficits-and-reactive-attachment-disorder
#3
Randall Phelps, Debra Eisert, Susan Schulz, Marilyn Augustyn
Alex is a 9-year-old boy brought to you, his primary care provider, for a "fifth opinion." You have cared for Alex since he was adopted from a Romanian orphanage at 3 years of age. He has been physically healthy with normal growth parameters and no evidence of fetal alcohol syndrome. Alex has long-standing history of social difficulties, impulsivity, lying, controlling, manipulative behaviors, violent outbursts at home with subsequent lack of remorse, and excessive chatter. You referred Alex to an interdisciplinary child development clinic 2 years ago, where he was diagnosed with reactive attachment disorder (RAD) and attention deficit hyperactivity disorder (ADHD)...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28107847/the-effect-of-watching-funny-and-unfunny-videos-on-post-surgical-pain-levels
#4
Hülya Elmali, Reva Balci Akpinar
OBJECTIVE: The aim of this study was to describe pain intensity before and after watching funny and unfunny videos on post-surgical pain levels. METHODS: Ninety patients were divided into three groups. Group A watched funny videos, Group B watched unfunny videos, Group C did not watch any videos. Pain assessment of the patients was carried out before (first), immediately after (second), and 30 min after (third) watching videos. RESULTS: The first pain scoremean in Group A was 40...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28057842/cyclic-amp-reverses-the-effects-of-aging-on-pacemaker-activity-and-if-in-sinoatrial-node-myocytes
#5
Emily J Sharpe, Eric D Larson, Catherine Proenza
Aerobic capacity decreases with age, in part because of an age-dependent decline in maximum heart rate (mHR) and a reduction in the intrinsic pacemaker activity of the sinoatrial node of the heart. Isolated sinoatrial node myocytes (SAMs) from aged mice have slower spontaneous action potential (AP) firing rates and a hyperpolarizing shift in the voltage dependence of activation of the "funny current," If Cyclic AMP (cAMP) is a critical modulator of both AP firing rate and If in SAMs. Here, we test the ability of endogenous and exogenous cAMP to overcome age-dependent changes in acutely isolated murine SAMs...
February 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28057841/it-s-not-funny-how-changes-in-if-limit-maximum-heart-rate-with-aging
#6
Gail A Robertson
No abstract text is available yet for this article.
February 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28007611/time-course-and-localization-of-brain-activity-in-humor-comprehension-an-erp-sloreta-study
#7
Midori Shibata, Yuri Terasawa, Takahiro Osumi, Keita Masui, Yuichi Ito, Arisa Sato, Satoshi Umeda
Although a number of studies have investigated the incongruity-detection and resolution process in humor comprehension, it is difficult to functionally and anatomically dissociate these processes. We used event-related potentials (ERP) and standardized low resolution brain electromagnetic tomography analysis (sLORETA) to examine the time course and localization of brain activity during incongruity detection and resolution. We used the same materials as in our previous fMRI study. Eighteen participants read funny and unfunny scenarios and judged whether the target sentence was funny or not...
December 19, 2016: Brain Research
https://www.readbyqxmd.com/read/27998695/influence-of-label-design-on-children-s-perception-of-2-snack-foods
#8
Alejandra Arrúa, Leticia Vidal, Lucía Antúnez, Leandro Machín, Joseline Martínez, María Rosa Curutchet, Ana Giménez, Gastón Ares
OBJECTIVE: To evaluate the influence of label design on children's perception of 2 popular snack foods across 3 income levels. DESIGN: Labels of 2 snack products (yogurt and sponge cake) were designed using a fractional factorial design with 3 2-level variables: cartoon character, nutrition claims, and front-of-package nutritional information. PARTICIPANTS: A total of 221 children (aged 9-13 years) from Montevideo, Uruguay, with different income levels, participated in the study...
December 17, 2016: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/27895488/advances-in-the-management-of-heart-failure-the-role-of-ivabradine
#9
REVIEW
Ursula Müller-Werdan, Georg Stöckl, Karl Werdan
A high resting heart rate (≥70-75 b.p.m.) is a risk factor for patients with heart failure (HF) with reduced ejection fraction (EF), probably in the sense of accelerated atherosclerosis, with an increased morbidity and mortality. Beta-blockers not only reduce heart rate but also have negative inotropic and blood pressure-lowering effects, and therefore, in many patients, they cannot be given in the recommended dose. Ivabradine specifically inhibits the pacemaker current (funny current, If) of the sinoatrial node cells, resulting in therapeutic heart rate lowering without any negative inotropic and blood pressure-lowering effect...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27803673/electrophysiological-mechanisms-of-brugada-syndrome-insights-from-pre-clinical-and-clinical-studies
#10
REVIEW
Gary Tse, Tong Liu, Ka H C Li, Victoria Laxton, Yin W F Chan, Wendy Keung, Ronald A Li, Bryan P Yan
Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which encodes for the cardiac Na(+) channel. To date, variants in 19 genes have been implicated in this condition, with 11, 5, 3, and 1 genes affecting the Na(+), K(+), Ca(2+), and funny currents, respectively. Diagnosis of BrS is based on ECG criteria of coved- or saddle-shaped ST segment elevation and/or T-wave inversion with or without drug challenge...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27784749/registered-replication-report-strack-martin-stepper-1988
#11
E-J Wagenmakers, Titia Beek, Laura Dijkhoff, Quentin F Gronau
According to the facial feedback hypothesis, people's affective responses can be influenced by their own facial expression (e.g., smiling, pouting), even when their expression did not result from their emotional experiences. For example, Strack, Martin, and Stepper (1988) instructed participants to rate the funniness of cartoons using a pen that they held in their mouth. In line with the facial feedback hypothesis, when participants held the pen with their teeth (inducing a "smile"), they rated the cartoons as funnier than when they held the pen with their lips (inducing a "pout")...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27784216/ivabradine-a-current-overview
#12
Kaushik Guha, Christopher J Allen, Adam Hartley, Rakesh Sharma
Ivabradine, acting on the funny channel in the sino-atrial node, is a promising drug in the treatment of ischaemic heart disease and heart failure. There has been much clinical research conducted exploring its role in these fields. This review discusses the drug development and trial data, and highlights future directions for research.
October 25, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27756763/humor-appreciation-involves-parametric-and-synchronized-activity-in-the-medial-prefrontal-cortex-and-hippocampus
#13
Tetsuya Iidaka
Humor perception is a ubiquitous phenomenon in human societies. In theories of humor perception, three factors, non-seriousness, social context, and incongruity, have been implicated in humor. In another theory, however, elaboration and reinterpretation of contexts are considered to play a role in eliciting humor. Although the neural correlates of humor appreciation have been investigated using neuroimaging methods, only a few studies have conducted such experiments under natural conditions. In the present study, two functional magnetic resonance imaging experiments, using a comedy movie as a stimulus, were conducted to investigate the neural correlates of humor under natural conditions...
October 18, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27752846/ivabradine
#14
Michel Komajda
Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary background therapy including betablockers (SHIFT: Systolic Heart Failure Treatment with the If inhibitor Trial).The primary composite endpoint (cardiovascular mortality or heart failure hospitalization) was reduced by 18% whereas the first occurrence of heart failure hospitalizations was reduced by 26%...
October 18, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27659287/emerging-role-of-ivabradine-for-rate-control-in-atrial-fibrillation
#15
REVIEW
Sarah L Turley, Kerry E Francis, Denise K Lowe, William D Cahoon
Control of ventricular rate is recommended for patients with paroxysmal, persistent, or permanent atrial fibrillation (AF). Existing rate-control options, including beta-blockers, nondihydropyridine calcium channel blockers, and digoxin, are limited by adverse hemodynamic effects and their ability to attain target heart rate (HR). Ivabradine, a novel HR-controlling agent, decreases HR through deceleration of conduction through If ('funny') channels, and is approved for HR reduction in heart failure patients with ejection fraction less than 35% and elevated HR, despite optimal pharmacological treatment...
December 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27610443/overcoming-challenges-faced-by-breastfeeding-mothers
#16
Lisa H Amir, Anita Bearzatto
BACKGROUND: Women who are breastfeeding often consult their general practitioner (GP) with concerns about nipple and breast pain, or the adequacy of their milk supply. Common concerns for their breastfed infant include slow weight gain, 'fussiness' with breastfeeding and 'funny stools'. OBJECTIVE: This article offers suggestions for clinicians to support breastfeeding women and their infants. DISCUSSION: Good attachment to the breast is important to reduce nipple pain and trauma, and to ensure adequate breast drainage and ongoing milk supply...
August 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27604049/unveiling-self-harm-behaviour-what-can-social-media-site-twitter-tell-us-about-self-harm-a-qualitative-exploration
#17
Charlotte Emma Hilton
AIMS AND OBJECTIVES: To report the findings from a unique analysis of naturally occurring data regarding self-harm behaviour generated through the global social media site, Twitter. BACKGROUND: Self-harm behaviours are of global concern for health and social care practice. However, little is known about the experiences of those who harm and the attitudes of the general public towards such behaviours. A deeper, richer and more organic understanding of this is vital to informing global approaches to supporting individuals through treatment and recovery...
September 7, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27582665/normal-variant-funny-looking-or-atypical-hippocampus-what-does-it-have-to-do-with-epilepsy
#18
Ajay Gupta
No abstract text is available yet for this article.
July 2016: Epilepsy Currents
https://www.readbyqxmd.com/read/27555825/-the-bitter-laughter-when-parody-is-a-moral-and-affective-priming-in-political-persuasion
#19
Francesca D'Errico, Isabella Poggi
Research on socially aware systems requires fine-grained knowledge of the mechanisms of persuasion in order to promote civic knowledge and aware political participation. Within humor studies, political parody is generally considered a simple pleasant weapon for political evaluation, currently explained by referring to the so called "just a joke effect" (Nabi et al., 2007). Indeed the funny side of parody can induce positive emotions, but it also includes a discrediting act that sometimes produces a "bitter laughter...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27547256/strategically-funny-romantic-motives-affect-humor-style-in-relationship-initiation
#20
Theresa E DiDonato, Brittany K Jakubiak
Not all humor is the same, yet little is known about the appeal of specific humor styles in romantic initiation. The current experimental study addresses this gap by investigating how romantic motives (short-term or long-term) affect individuals' anticipated use of, and response to, positive humor and negative humor. Heterosexual participants (n = 224) imagined the pursuit of either a desired short-term or long-term relationship, indicated the extent to which they would produce positive and negative humor, and reported how their own interest would change in response to the imaginary target's use of positive or negative humor...
August 2016: Europe's journal of psychology
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