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https://www.readbyqxmd.com/read/29115193/personality-modulates-amygdala-and-insula-connectivity-during-humor-appreciation-an-event-related-fmri-study
#1
Philipp Berger, Florian Bitsch, Arne Nagels, Benjamin Straube, Irina Falkenberg
Previous research and theory implicate that personality traits, such as extraversion and neuroticism, influence the processing of humor, as indicated by alterations in the activation of fronto-temporal and mesocorticolimbic brain regions during humor processing. In the current study, we sought to complement these findings by testing whether inter-individual differences in functional connectivity of humor-related brain regions are modulated by stable personality characteristics during humor processing. Using fMRI techniques, we studied 19 healthy subjects during the processing of standardized humorous and neutral cartoons...
November 8, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/29107716/pacsin-2-is-required-for-the-maintenance-of-a-normal-cardiac-function-in-the-developing-mouse-heart
#2
Judith Semmler, Jan Kormann, Sureshkumar Perumal Srinivasan, Annette Köster, Daniel Sälzer, Michael Reppel, Jürgen Hescheler, Markus Plomann, Filomain Nguemo
The Pacsin proteins (Pacsin 1, 2 and 3) play an important role in intracellular trafficking and thereby signal transduction in many cells types. This study was designed to examine the role of Pacsin 2 in cardiac development and function. We investigated the development and electrophysiological properties of Pacsin 2 knockout (P2KO) hearts and single cardiomyocytes isolated from 11.5 and 15.5days old fetal mice. Immunofluorescence experiments confirmed the lack of Pacsin 2 protein expression in P2KO cardiac myocytes in comparison to wildtype (WT)...
October 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29098274/developing-appreciation-for-sarcasm-and-sarcastic-gossip-it-depends-on-perspective
#3
Melanie Glenwright, Brent Tapley, Jacqueline K S Rano, Penny M Pexman
Background: Speakers use sarcasm to criticize others and to be funny; the indirectness of sarcasm protects the addressee's face (Brown & Levinson, 1987). Thus, appreciation of sarcasm depends on the ability to consider perspectives. Purpose: We investigated development of this ability from late childhood into adulthood and examined effects of interpretive perspective and parties present. Method: We presented 9- to 10-year-olds, 13- to 14-year-olds, and adults with sarcastic and literal remarks in three parties-present conditions: private evaluation, public evaluation, and gossip...
November 9, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29078315/one-to-four-year-olds-connect-diverse-positive-emotional-vocalizations-to-their-probable-causes
#4
Yang Wu, Paul Muentener, Laura E Schulz
The ability to understand why others feel the way they do is critical to human relationships. Here, we show that emotion understanding in early childhood is more sophisticated than previously believed, extending well beyond the ability to distinguish basic emotions or draw different inferences from positively and negatively valenced emotions. In a forced-choice task, 2- to 4-year-olds successfully identified probable causes of five distinct positive emotional vocalizations elicited by what adults would consider funny, delicious, exciting, sympathetic, and adorable stimuli (Experiment 1)...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29060085/video-analysis-of-youtube-funnies-to-aid-the-study-of-human-gait-and-falls-preliminary-results-and-proof-of-concept
#5
Babak Taati, Pranay Lohia, Avril Mansfield, Ahmed B Ashraf
Because falls are funny, YouTube and other video sharing sites contain a large repository of real-life falls. We propose extracting gait and balance information from these videos to help us better understand some of the factors that contribute to falls. Proof-of-concept is explored in a single video containing multiple (n=14) falls/non-falls in the presence of an unexpected obstacle. The analysis explores: computing spatiotemporal parameters of gait in a video captured from an arbitrary viewpoint; the relationship between parameters of gait from the last few steps before the obstacle and falling vs...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28960127/use-of-short-animal-themed-videos-to-enhance-veterinary-students-mood-attention-and-understanding-of-pharmacology-lectures
#6
Lori R Kogan, Pete Hellyer, Tod R Clapp, Erica Suchman, Jennifer McLean, Regina Schoenfeld-Tacher
Professional DVM training is inherently stressful and challenging for students. This study evaluated a simple intervention-short breaks during a veterinary pharmacology lecture course in the form of funny/cute animal videos (Mood Induction Procedures, or MIP)-to assess for potential impact on students' mood, interest in material, and perceived understanding of material. Ten YouTube video clips showing cats or dogs were selected to influence students' affective states. The videos were shown in a required pharmacology class offered during the fall semester of the second year of the DVM program at a large, land-grant institution in the Western US...
September 29, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28958335/the-clinical-use-of-ivabradine
#7
REVIEW
Jacob S Koruth, Anuradha Lala, Sean Pinney, Vivek Y Reddy, Srinivas R Dukkipati
The clinical use of ivabradine has and continues to evolve along channels that are predicated on its mechanism of action. It selectively inhibits the funny current (If) in sinoatrial nodal tissue, resulting in a decrease in the rate of diastolic depolarization and, consequently, the heart rate, a mechanism that is distinct from those of other negative chronotropic agents. Thus, it has been evaluated and is used in select patients with systolic heart failure and chronic stable angina without clinically significant adverse effects...
October 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28952785/frightfully-funny-combining-threat-and-humour-in-health-messages-for-men-and-women
#8
Hanneke Hendriks, Loes Janssen
OBJECTIVE: It is imperative for public health to investigate what factors may reduce defensive responses and increase the effectiveness of health information. The present research investigated gender differences in responses to threatening health-promoting information communicated with humour. DESIGN: Male and female participants were exposed to a health message stressing the negative consequences of binge drinking (Experiment 1; N = 209) or caffeine consumption (Experiment 2; N = 242), that did or did not contain a funny visual metaphor (Experiment 1) or a slapstick cartoon (Experiment 2)...
September 27, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28930912/reducing-elevated-heart-rates-in-patients-with-multiple-organ-dysfunction-syndrome-with-the-if-funny-channel-current-inhibitor-ivabradine
#9
Sebastian Nuding, Jochen Schröder, Peter Presek, Andreas Wienke, Ursula Müller-Werdan, Henning Ebelt, Karl Werdan
INTRODUCTION: A heart rate higher than 90 beats/min indicates an unfavorable prognosis for patients with multiple organ dysfunction syndrome (MODS). We sought to investigate the effect of the pacemaker current (If) inhibitor ivabradine on heart rate, hemodynamics, and disease severity among patients with MODS. MATERIAL AND METHODS: In this prospective, controlled, randomized, open-label, two-arm phase II trial, seventy patients with MODS, a sinus rhythm of at least 90 beats/min, and contraindications to β-blocker therapy were randomly assigned to receive the standard treatment ± ivabradine (5 mg twice daily) for 96 h via the enteral route...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28868308/phosphodiesterases-3-and-4-differentially-regulate-the-funny-current-if-in-mouse-sinoatrial-node-myocytes
#10
Joshua R St Clair, Eric D Larson, Emily J Sharpe, Zhandi Liao, Catherine Proenza
Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3',5'-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs). The cardiac "funny current" (If) is among the cAMP-sensitive effectors that drive pacemaking in SAMs. If is produced by hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels. Voltage-dependent gating of HCN channels is potentiated by cAMP, which acts either by binding directly to the channels or by activating the cAMP-dependent protein kinase (PKA), which phosphorylates them...
September 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/28857002/the-fragile-brain-the-strange-hopeful-science-of-dementia-taylor-kathleen-the-fragile-brain-the-strange-hopeful-science-of-dementia-336pp-%C3%A2-20-oxford-university-press-9780198726081-0198726082-formula-see-text
#11
(no author information available yet)
This is the best book I have read on dementia. It is an intricate and intense read, making it ideal for people who want to understand the complexity of brain failure. The author is funny and interesting in the analogies she uses to convey the science.
August 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28855177/small-functional-if-current-in-sinoatrial-pacemaker-cells-of-the-brown-trout-salmo-trutta-fario-heart-despite-strong-expression-of-hcn-channel-transcripts
#12
Minna Hassinen, Jaakko Haverinen, Matti Vornanen
Funny current (If), formed by hyperpolarization-activated HCN channels, is supposed to be crucial for membrane clock regulating the cardiac pacemaker mechanism. We examined the presence and activity of HCN channels in the brown trout (Salmo trutta fario) sinoatrial (SA) pacemaker cells, and their putative role in heart rate (fH) regulation. Six HCN transcripts (HCN1, HCN2a, HCN2ba, HCN2bb, HCN3 and HCN4) were expressed in the brown trout heart. The total HCN transcript abundance was 4.0 and 4.9 times higher in SA pacemaker tissue than in atrium and ventricle, respectively...
August 30, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28801065/multimodal-mental-imagery
#13
REVIEW
Bence Nanay
When I am looking at my coffee machine that makes funny noises, this is an instance of multisensory perception - I perceive this event by means of both vision and audition. But very often we only receive sensory stimulation from a multisensory event by means of one sense modality, for example, when I hear the noisy coffee machine in the next room, that is, without seeing it. The aim of this paper is to bring together empirical findings about multimodal perception and empirical findings about (visual, auditory, tactile) mental imagery and argue that on occasions like this, we have multimodal mental imagery: perceptual processing in one sense modality (here: vision) that is triggered by sensory stimulation in another sense modality (here: audition)...
July 17, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28746244/the-effect-of-unicycle-riding-course-on-trunk-strength-and-trunk-stability-functions-in-children
#14
Andrej Kocjan, Nejc Sarabon
PURPOSE: The aim of the study was to assess the effect of unicycling on trunk strength and timing of automatic stability actions of the selected trunk muscles (multifidus, obliquus externus, erector spine). METHODS: Twenty healthy 12-year-old children (12 boys, 8 girls; age 12.1 ± 0.2 yrs; body height 1.57 ± 0.05 m; body mass 52.8 ± 10.6 kg) were assigned to experimental and control group. Experimental group performed a supervised 12-session course of unicycling...
July 24, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28740440/haphop-physio-a-computer-game-to-support-cognitive-therapies-in-children
#15
Carolina Rico-Olarte, Diego M López, Santiago Narváez, Charic D Farinango, Peter S Pharow
BACKGROUND: Care and support of children with physical or mental disabilities are accompanied with serious concerns for parents, families, healthcare institutions, schools, and their communities. Recent studies and technological innovations have demonstrated the feasibility of providing therapy and rehabilitation services to children supported by computer games. OBJECTIVE: The aim of this paper is to present HapHop-Physio, an innovative computer game that combines exercise with fun and learning, developed to support cognitive therapies in children...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28694363/no-laughing-matter-comedians-support-battersea-s-not-funny-campaign
#16
(no author information available yet)
No abstract text is available yet for this article.
July 7, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28652967/neural-circuit-of-verbal-humor-comprehension-in-schizophrenia-an-fmri-study
#17
Przemysław Adamczyk, Miroslaw Wyczesany, Aleksandra Domagalik, Artur Daren, Kamil Cepuch, Piotr Błądziński, Andrzej Cechnicki, Tadeusz Marek
Individuals with schizophrenia exhibit problems with understanding the figurative meaning of language. This study evaluates neural correlates of diminished humor comprehension observed in schizophrenia. The study included chronic schizophrenia (SCH) outpatients (n = 20), and sex, age and education level matched healthy controls (n = 20). The fMRI punchline based humor comprehension task consisted of 60 stories of which 20 had funny, 20 nonsensical and 20 neutral (not funny) punchlines. After the punchlines were presented, the participants were asked to indicate whether the story was comprehensible and how funny it was...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28623610/a-singular-role-of-ik1-promoting-the-development-of-cardiac-automaticity-during-cardiomyocyte-differentiation-by-ik1-induced-activation-of-pacemaker-current
#18
Yu Sun, Valeriy Timofeyev, Adrienne Dennis, Emre Bektik, Xiaoping Wan, Kenneth R Laurita, Isabelle Deschênes, Ronald A Li, Ji-Dong Fu
The inward rectifier potassium current (IK1) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently observed that IK1 could promote the spontaneously-firing automaticity induced by upregulation of pacemaker funny current (If) in adult ventricular cardiomyocytes (CMs). However, the intriguing ability of IK1 to activate If and thereby promote automaticity has not been explored. In this study, we combined mathematical and experimental assays and found that only IK1 and If, at a proper-ratio of densities, were sufficient to generate rhythmic MP-oscillations even in unexcitable cells (i...
October 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28587688/hot-and-cold-executive-functions-in-youth-with-psychotic-symptoms
#19
L E MacKenzie, V C Patterson, A Zwicker, V Drobinin, H L Fisher, S Abidi, A N Greve, A Bagnell, L Propper, M Alda, B Pavlova, R Uher
BACKGROUND: Psychotic symptoms are common in children and adolescents and may be early manifestations of liability to severe mental illness (SMI), including schizophrenia. SMI and psychotic symptoms are associated with impairment in executive functions. However, previous studies have not differentiated between 'cold' and 'hot' executive functions. We hypothesized that the propensity for psychotic symptoms is specifically associated with impairment in 'hot' executive functions, such as decision-making in the context of uncertain rewards and losses...
December 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28583386/laugh-or-cringe-common-and-distinct-processes-of-reward-based-schadenfreude-and-empathy-based-fremdscham
#20
Frieder M Paulus, Laura Müller-Pinzler, David S Stolz, Annalina V Mayer, Lena Rademacher, Sören Krach
Witnessing others' plights can be funny for observers, but may also trigger one to empathically cringe with the victim of the predicament. In the present study, we examined the common and distinct neural networks involved in schadenfreude (i.e. pleasure derived from another's misfortune) and fremdscham (i.e. empathically sharing the embarrassment about another's misfortune). Using functional magnetic resonance imaging we examined a total of N = 34 participants while they observed social integrity threats of a misfortunate other and either reported on their schadenfreude or fremdscham...
June 2, 2017: Neuropsychologia
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