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https://www.readbyqxmd.com/read/27895488/advances-in-the-management-of-heart-failure-the-role-of-ivabradine
#1
REVIEW
Ursula Müller-Werdan, Georg Stöckl, Karl Werdan
A high resting heart rate (≥70-75 b.p.m.) is a risk factor for patients with heart failure (HF) with reduced ejection fraction (EF), probably in the sense of accelerated atherosclerosis, with an increased morbidity and mortality. Beta-blockers not only reduce heart rate but also have negative inotropic and blood pressure-lowering effects, and therefore, in many patients, they cannot be given in the recommended dose. Ivabradine specifically inhibits the pacemaker current (funny current, If) of the sinoatrial node cells, resulting in therapeutic heart rate lowering without any negative inotropic and blood pressure-lowering effect...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27803673/electrophysiological-mechanisms-of-brugada-syndrome-insights-from-pre-clinical-and-clinical-studies
#2
REVIEW
Gary Tse, Tong Liu, Ka H C Li, Victoria Laxton, Yin W F Chan, Wendy Keung, Ronald A Li, Bryan P Yan
Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which encodes for the cardiac Na(+) channel. To date, variants in 19 genes have been implicated in this condition, with 11, 5, 3, and 1 genes affecting the Na(+), K(+), Ca(2+), and funny currents, respectively. Diagnosis of BrS is based on ECG criteria of coved- or saddle-shaped ST segment elevation and/or T-wave inversion with or without drug challenge...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27784749/registered-replication-report-strack-martin-stepper-1988
#3
E-J Wagenmakers, Titia Beek, Laura Dijkhoff, Quentin F Gronau
According to the facial feedback hypothesis, people's affective responses can be influenced by their own facial expression (e.g., smiling, pouting), even when their expression did not result from their emotional experiences. For example, Strack, Martin, and Stepper (1988) instructed participants to rate the funniness of cartoons using a pen that they held in their mouth. In line with the facial feedback hypothesis, when participants held the pen with their teeth (inducing a "smile"), they rated the cartoons as funnier than when they held the pen with their lips (inducing a "pout")...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27784216/ivabradine-a-current-overview
#4
Kaushik Guha, Christopher J Allen, Adam Hartley, Rakesh Sharma
Ivabradine, acting on the funny channel in the sino-atrial node, is a promising drug in the treatment of ischaemic heart disease and heart failure. There has been much clinical research conducted exploring its role in these fields. This review discusses the drug development and trial data, and highlights future directions for research.
October 25, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27756763/humor-appreciation-involves-parametric-and-synchronized-activity-in-the-medial-prefrontal-cortex-and-hippocampus
#5
Tetsuya Iidaka
Humor perception is a ubiquitous phenomenon in human societies. In theories of humor perception, three factors, non-seriousness, social context, and incongruity, have been implicated in humor. In another theory, however, elaboration and reinterpretation of contexts are considered to play a role in eliciting humor. Although the neural correlates of humor appreciation have been investigated using neuroimaging methods, only a few studies have conducted such experiments under natural conditions. In the present study, two functional magnetic resonance imaging experiments, using a comedy movie as a stimulus, were conducted to investigate the neural correlates of humor under natural conditions...
October 18, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27752846/ivabradine
#6
Michel Komajda
Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary background therapy including betablockers (SHIFT: Systolic Heart Failure Treatment with the If inhibitor Trial).The primary composite endpoint (cardiovascular mortality or heart failure hospitalization) was reduced by 18% whereas the first occurrence of heart failure hospitalizations was reduced by 26%...
October 18, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27659287/emerging-role-of-ivabradine-for-rate-control-in-atrial-fibrillation
#7
REVIEW
Sarah L Turley, Kerry E Francis, Denise K Lowe, William D Cahoon
Control of ventricular rate is recommended for patients with paroxysmal, persistent, or permanent atrial fibrillation (AF). Existing rate-control options, including beta-blockers, nondihydropyridine calcium channel blockers, and digoxin, are limited by adverse hemodynamic effects and their ability to attain target heart rate (HR). Ivabradine, a novel HR-controlling agent, decreases HR through deceleration of conduction through If ('funny') channels, and is approved for HR reduction in heart failure patients with ejection fraction less than 35% and elevated HR, despite optimal pharmacological treatment...
December 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27610443/overcoming-challenges-faced-by-breastfeeding-mothers
#8
Lisa H Amir, Anita Bearzatto
BACKGROUND: Women who are breastfeeding often consult their general practitioner (GP) with concerns about nipple and breast pain, or the adequacy of their milk supply. Common concerns for their breastfed infant include slow weight gain, 'fussiness' with breastfeeding and 'funny stools'. OBJECTIVE: This article offers suggestions for clinicians to support breastfeeding women and their infants. DISCUSSION: Good attachment to the breast is important to reduce nipple pain and trauma, and to ensure adequate breast drainage and ongoing milk supply...
August 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27604049/unveiling-self-harm-behaviour-what-can-social-media-site-twitter-tell-us-about-self-harm-a-qualitative-exploration
#9
Charlotte Hilton
AIMS AND OBJECTIVES: To report the findings from a unique analysis of naturally occurring data regarding self-harm behaviour generated through the global social media site, Twitter. BACKGROUND: Self-harm behaviours are of global concern for health and social care practice. However, little is known about the experiences of those who harm and the attitudes of the general public towards such behaviours. A deeper, richer and more organic understanding of this is vital to informing global approaches to supporting individuals through treatment and recovery...
September 7, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27582665/normal-variant-funny-looking-or-atypical-hippocampus-what-does-it-have-to-do-with-epilepsy
#10
Ajay Gupta
No abstract text is available yet for this article.
July 2016: Epilepsy Currents
https://www.readbyqxmd.com/read/27555825/-the-bitter-laughter-when-parody-is-a-moral-and-affective-priming-in-political-persuasion
#11
Francesca D'Errico, Isabella Poggi
Research on socially aware systems requires fine-grained knowledge of the mechanisms of persuasion in order to promote civic knowledge and aware political participation. Within humor studies, political parody is generally considered a simple pleasant weapon for political evaluation, currently explained by referring to the so called "just a joke effect" (Nabi et al., 2007). Indeed the funny side of parody can induce positive emotions, but it also includes a discrediting act that sometimes produces a "bitter laughter...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27547256/strategically-funny-romantic-motives-affect-humor-style-in-relationship-initiation
#12
Theresa E DiDonato, Brittany K Jakubiak
Not all humor is the same, yet little is known about the appeal of specific humor styles in romantic initiation. The current experimental study addresses this gap by investigating how romantic motives (short-term or long-term) affect individuals' anticipated use of, and response to, positive humor and negative humor. Heterosexual participants (n = 224) imagined the pursuit of either a desired short-term or long-term relationship, indicated the extent to which they would produce positive and negative humor, and reported how their own interest would change in response to the imaginary target's use of positive or negative humor...
August 2016: Europe's journal of psychology
https://www.readbyqxmd.com/read/27469009/-haematological-cancers-they-re-a-funny-bunch-a-qualitative-study-of-non-hodgkin-s-lymphoma-patient-experiences-of-unmet-supportive-care-needs
#13
Brooke Swash, Nick Hulbert-Williams, Ros Bramwell
Despite high levels of psychological distress, there is a scarcity of research on unmet supportive care needs in haematological cancer patients. This qualitative study used an in-depth interpretative phenomenological approach to investigate the needs reported by six non-Hodgkin's lymphoma patients and explored how these needs consequently shaped the patient experience. Emergent themes included the following: concerns for family, information needs and the need for psychological support. Participants reported feeling different to other cancer patients...
July 28, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27397799/on-bias-and-precision-in-meta-analysis-the-error-in-the-error
#14
Thomas F Hansen
Bias is a funny term. Its vernacular meaning is a lack of objectivity resulting in partial or prejudiced view or reporting on a subject. To anyone but a statistician a characterization of a method as biased sounds like a devastating criticism. In statistics, however, bias has a precise meaning as the difference between the expected value of an estimator and the true value of the parameter it seeks to estimate. Some good estimators are biased, and some unbiased estimators are not good. A better criterion for a good estimator is accuracy, the expected distance from the true value...
July 10, 2016: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/27394976/is-the-last-man-standing-in-comedy-the-least-funny-a-retrospective-cohort-study-of-elite-stand-up-comedians-versus-other-entertainers
#15
Simon Stewart, Joshua F Wiley, Cressida J McDermott, David R Thompson
BACKGROUND: This study aimed to confirm, in a large, diverse cohort of elite Stand-up Comedians and other entertainers, that there is an inverse association between comedic ability and longevity. METHODS: This retrospective cohort study included 200 Stand-up Comedians (13% women), 113 Comedy Actors (17.5% women), and 184 Dramatic Actors (29.3% women) listed in the top 200 in each category in a popular online ranking website. Longevity within each group was examined adjusting for life expectancy by year of birth and within-group ranking score...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27377956/impact-of-seductive-details-on-the-acquisition-and-transfer-of-laparoscopic-suturing-skills-emotionally-interesting-or-cognitively-taxing
#16
Aimee K Gardner, Jesse Clanton, Ibrahim I Jabbour, Lauren Scott, Daniel J Scott, Michael A Russo
BACKGROUND: A common strategy to increase learner engagement is to interweave educational material with interesting but slightly tangential tidbits of information (eg, "war stories" and funny anecdotes), known as seductive details. Our objective was to examine the impact of seductive details on initial acquisition and transfer of basic laparoscopic surgical skills. METHODS: Novices (first- to fourth-year medical students) were randomized into control (N = 47) or seductive details (N = 42) groups...
September 2016: Surgery
https://www.readbyqxmd.com/read/27365157/local-field-potentials-get-funny
#17
Matthew F Nolan
No abstract text is available yet for this article.
July 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27295092/prenatal-nicotine-exposure-results-in-the-inhibition-of-baroreflex-sensitivity-induced-by-intravenous-injection-angiotensin-ii-in-the-adult-male-offspring-rats
#18
Feng Yu, Yuexia Li, Jian Yang, Jin Qian, Xining Li, Chongbin Liu
Epidemiological studies show that maternal cigarette smoking is associated with an increased risk of cardiovascular diseases in postnatal life. Baroreflex sensitivity (BRS) is an important index for evaluating the homeostasis of the cardiovascular system. This experiment was designed to investigate the possible mechanism of prenatal nicotine on the adult male offspring's heart rate (HR) increase due to BRS. Pregnant rats received the 0.3 ml of saline or nicotine (1.5 mg kg(-1)) by subcutaneous injection from gestational days 3 to 21...
June 13, 2016: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/27280207/early-funny-stardust-memories
#19
Laura Thomas
No abstract text is available yet for this article.
February 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27247678/being-irrationally-funny-as-a-cognitive-psychologist-interview-with-dan-ariely
#20
Dan Ariely, Beatrice Popescu
The idea of interviewing Dan Ariely was somehow latent on my mind since I started being interested in cognitive psychology and cognitive behavior psychotherapy, but actually got more ardent ever since irrationality became a research topic for his team at Duke University. I picked him as an interviewee thinking not only at his exceptional skills as a researcher and as Kahnemann 'disciple', but mainly for his fantastic wit, true modesty and utmost interest in making people's lives easier and more comfortable, by creating awareness on a lot of topics otherwise neglected...
November 2015: Europe's journal of psychology
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