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https://www.readbyqxmd.com/read/28944915/neuroprotective-effect-of-total-flavonoids-from-ilex-pubescens-against-focal-cerebral-ischemia-reperfusion-injury-in-rats
#1
Xiaoyan Fang, Yujie Li, Jingyi Qiao, Ying Guo, Mingsan Miao
Ilex pubescens is commonly used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases, such as coronary artery disease and stroke. However, the underlying mechanisms remain to be fully elucidated. The aim of the present study was to investigate the effects of Ilex pubescens total flavonoids (IPTF) on neuroprotection and the potential mechanisms in a rat model of focal cerebral ischemia/reperfusion (I/R) injury. Rats were pretreated with intragastric administration of IPTF at doses of 200 and 100 mg/kg for 5 days; middle cerebral artery occlusion surgery was then performed to induce cerebral I/R injury...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944551/mendelian-randomization-with-fine-mapped-genetic-data-choosing-from-large-numbers-of-correlated-instrumental-variables
#2
Stephen Burgess, Verena Zuber, Elsa Valdes-Marquez, Benjamin B Sun, Jemma C Hopewell
Mendelian randomization uses genetic variants to make causal inferences about the effect of a risk factor on an outcome. With fine-mapped genetic data, there may be hundreds of genetic variants in a single gene region any of which could be used to assess this causal relationship. However, using too many genetic variants in the analysis can lead to spurious estimates and inflated Type 1 error rates. But if only a few genetic variants are used, then the majority of the data is ignored and estimates are highly sensitive to the particular choice of variants...
September 25, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28944218/diabetes-mitigates-the-role-of-memory-complaint-in-predicting-dementia-risk-results-from-the-prevention-of-alzheimer-s-disease-with-vitamin-e-and-selenium-study
#3
X Zhang, F A Schmitt, A M Caban-Holt, X Ding, R J Kryscio, E Abner
BACKGROUND: Subjective memory complaints (SMCs) are associated with increased risk of dementia in older adults, but the role of comorbidities in modifying this risk is unknown. OBJECTIVES: To assess whether comorbidities modify estimated dementia risk based on SMCs. DESIGN: The Prevention of Alzheimer's Disease with Vitamin E and Selenium Study (PREADVISE) was designed as an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a randomized, multi-center prostate cancer prevention trial with sites in the Unites States, Puerto Rico, and Canada...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/28943008/development-and-validation-of-a-score-to-predict-life-expectancy-after-carotid-endarterectomy-in-asymptomatic-patients
#4
Michele Carmo, Iacopo Barbetta, Daniele Bissacco, Santi Trimarchi, Vincenzo Catanese, Matteo Bonzini, Stefano Bonardelli, Piergiorgio G Settembrini
OBJECTIVE: Recent improvement of best medical treatment for carotid stenosis has sparked a debate on the role of surgery identification of patients who may benefit from carotid endarterectomy (CEA) is crucial to avoid overtreatment. An expected 5-year postoperative survival is one of the main selection criteria. The aim of this study was the development of a score for predicting survival of asymptomatic patients after CEA. METHODS: Our score was derived from a retrospective analysis of 648 consecutive asymptomatic patients from a single hospital...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942979/differences-and-similarities-in-risk-factors-for-postoperative-acute-kidney-injury-between-younger-and-older-adults-undergoing-cardiac-surgery
#5
Nadim Saydy, Amine Mazine, Louis-Mathieu Stevens, Hughes Jeamart, Philippe Demers, Pierre Pagé, Yoan Lamarche, Ismail El-Hamamsy
OBJECTIVES: Acute kidney injury is a frequent complication after cardiac surgery. The purpose of this study was to assess the risk factors for acute kidney injury in patients ≤60 years of age undergoing cardiac surgery and to compare these risk factors with those identified in patients ≥65 years of age. METHODS: From 2010 to 2012, 1253 patients ≤60 years (mean age 52 ± 9 years) and 2488 patients ≥65 years (mean age 74 ± 6 years) underwent cardiac surgery...
August 26, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28942939/relation-of-coronary-flow-reserve-to-other-findings-on-positron-emission-tomography-myocardial-perfusion-imaging-and-left-heart-catheterization-in-patients-with-end-stage-renal-disease-being-evaluated-for-kidney-transplant
#6
Yehuda Paz, Rachelle Morgenstern, Richard Weinberg, Mariana Chiles, Navdeep Bhatti, Ziad Ali, Sumit Mohan, Sabahat Bokhari
Cardiovascular disease is the leading cause of death in patients with end-stage renal disease (ESRD) and often goes undetected. Abnormal coronary flow reserve (CFR), which predicts increased risk of cardiac death, may be present in patients with ESRD without other evidence of coronary artery disease (CAD). We prospectively studied 131 patients who had rest and dipyridamole pharmacologic stress N(13)-ammonia positron emission tomography myocardial perfusion imaging (PET MPI) for kidney transplant evaluation...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28942872/association-of-sst2-and-hs-crp-levels-with-new-onset-atrial-fibrillation-in-coronary-artery-disease
#7
Santeri Nortamo, Olavi Ukkola, Samuli Lepojärvi, Tuomas Kenttä, Antti Kiviniemi, Juhani Junttila, Heikki Huikuri, Juha Perkiömäki
BACKGROUND: The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited. METHODS: A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28942775/missed-diagnosis-of-cardiovascular-disease-in-outpatient-general-medicine-insights-from-malpractice-claims-data
#8
Gene R Quinn, Darrell Ranum, Ellen Song, Margarita Linets, Carol Keohane, Heather Riah, Penny Greenberg
BACKGROUND: Diagnostic errors are an underrecognized source of patient harm, and cardiovascular disease can be challenging to diagnose in the ambulatory setting. Although malpractice data can inform diagnostic error reduction efforts, no studies have examined outpatient cardiovascular malpractice cases in depth. A study was conducted to examine the characteristics of outpatient cardiovascular malpractice cases brought against general medicine practitioners. METHODS: Some 3,407 closed malpractice claims were analyzed in outpatient general medicine from CRICO Strategies' Comparative Benchmarking System database-the largest detailed database of paid and unpaid malpractice in the world-and multivariate models were created to determine the factors that predicted case outcomes...
October 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28942764/ocular-manifestations-of-obstructive-sleep-apnea
#9
Matthew Santos, R Jeffrey Hofmann
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) incurs a host of systemic side effects. The eyes are particularly susceptible to both mechanical and vascular sequelae of the disease. This paper outlines the ocular manifestations of sleep apnea. The authors hope to increase awareness of the ocular complications of this common disorder and increase communication and co-management between eye-care providers and sleep specialists alike. METHODS: Data were collected from PubMed and the Brown University Library Collection...
September 20, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28942735/representation-of-cardiovascular-magnetic-resonance-in-the-aha-acc-guidelines
#10
Florian von Knobelsdorff-Brenkenhoff, Guenter Pilz, Jeanette Schulz-Menger
BACKGROUND: Whereas evidence supporting the diagnostic value of cardiovascular magnetic resonance (CMR) has increased, there exists significant worldwide variability in the clinical utilization of CMR. A recent study demonstrated that CMR is represented in the majority of European Society for Cardiology (ESC) guidelines, with a large number of specific recommendations in particular regarding coronary artery disease. To further investigate the gap between the evidence and clinical use of CMR, this study analyzed the role of CMR in the guidelines of the American College of Cardiology (ACC) and American Heart Association (AHA)...
September 25, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28942444/peripheral-endothelial-function-and-coronary-flow-velocity-reserve-are-not-associated-in-women-with-angina-and-no-obstructive-coronary-artery-disease-the-ipower-study
#11
Kristoffer Flintholm Raft, Daria Frestad, Marie Mide Michelsen, Hannah Elena Suhrs, Anna Bay Rask, Malin Nilsson, Thomas Steffen Hermann, Eva Prescott
PURPOSE: We investigated whether impaired flow-mediated dilation (FMD) and plasma biomarkers reflecting endothelial dysfunction are associated with coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease (CAD). METHODS: Patients (n = 194) were randomly selected women with angina pectoris and no obstructive CAD (<50% stenosis). A reference population of asymptomatic women without CAD (n = 25) was included. We measured FMD in the brachial artery by high-resolution ultrasound...
September 23, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28942357/plasma-big-endothelin-1-and-stent-thrombosis-an-observational-study-in-patients-undergoing-percutaneous-coronary-intervention-in-china
#12
Yan Chen, Jian-Xin Li, Ying Song, Jing-Jing Xu, Xiao-Fang Tang, Lin Jiang, Ping Jiang, Ru Liu, Huan-Huan Wang, Xue-Yan Zhao, Jue Chen, Zhan Gao, Shu-Bin Qiao, Run-Lin Gao, Yue-Jin Yang, Bo Xu, Jin-Qing Yuan
INTRODUCTION: Stent thrombosis (ST) is a rare but catastrophic complication of percutaneous coronary intervention, leading to poor prognosis. Endothelin-1 (ET-1) plays an important role in endothelial dysfunction and thrombogenesis. However, the impact of big ET-1 level on ST in patients with coronary stenting is unknown. We aimed to evaluate big ET-1 level as a potential predictor of ST in patients undergoing percutaneous coronary intervention. MATERIALS AND METHODS: From January 2013 to December 2013, 8106 consecutive patients underwent successful coronary stent implantation and were prospectively enrolled in this study...
September 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28942284/the-relationship-of-plasma-decoy-receptor-3-and-coronary-collateral-circulation-in-patients-with-coronary-artery-disease
#13
Youyou Yan, Dandan Song, Lulu Liu, Xiuping Meng, Chao Qi, Junnan Wang
OBJECTIVE: Previously, decoy receptor 3 (DcR3) was found to be a potential angiogenetic factor, while the relationship of DcR3 with coronary collateral circulation formation has not been investigated. In this study, we aimed to investigate whether plasma decoy receptor 3 levels was associated with CCC formation and evaluate its predictive power for CCC status in patients with coronary artery disease. METHODS: Among patients who underwent coronary angiography with coronary artery disease and had a stenosis of ≥90% were included in our study...
September 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28941999/structured-reporting-platform-improves-cad-rads-assessment
#14
Bálint Szilveszter, Márton Kolossváry, Júlia Karády, Ádám L Jermendy, Mihály Károlyi, Alexisz Panajotu, Zsolt Bagyura, Milán Vecsey-Nagy, Ricardo C Cury, Jonathon A Leipsic, Béla Merkely, Pál Maurovich-Horvat
BACKGROUND: Structured reporting in cardiac imaging is strongly encouraged to improve quality through consistency. The Coronary Artery Disease - Reporting and Data System (CAD-RADS) was recently introduced to facilitate interdisciplinary communication of coronary CT angiography (CTA) results. We aimed to assess the agreement between manual and automated CAD-RADS classification using a structured reporting platform. METHODS: Five readers prospectively interpreted 500 coronary CT angiographies using a structured reporting platform that automatically calculates the CAD-RADS score based on stenosis and plaque parameters manually entered by the reader...
September 18, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28941610/scavenger-receptor-lox1-genotype-predicts-coronary-artery-disease-in-patients-with-familial-hypercholesterolemia
#15
Martine Paquette, Robert Dufour, Alexis Baass
BACKGROUND: Familial hypercholesterolemia (FH) is a monogenic disease associated with elevated low-density lipoprotein (LDL) cholesterol and oxidized LDL (oxLDL) leading to premature cardiovascular disease. Lectin-like oxLDL receptor-1 (LOX1) is one of the major contributors of oxLDL uptake and degradation in macrophages, which leads to foam cell formation and the development of atherosclerosis. This study investigated the effect of the rs11053646 genotype of the oxidized low-density lipoprotein receptor 1 (OLR1) gene on coronary artery disease (CAD) risk in a cohort of FH patients...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28941481/does-the-new-generation-of-drug-eluting-stents-render-bare-metal-stents-obsolete
#16
REVIEW
Kyle Buchanan, Arie Steinvil, Ron Waksman
The development of bare metal coronary stents revolutionized the treatment of coronary artery disease by reducing rates of acute vessel closure and restenosis associated with balloon angioplasty. However, bare metal stents (BMS) resulted in high rates of restenosis and led to the development of drug-eluting stents (DES). Those first-generation DES were followed by successive generations of DES that included improvements, such as biodegradable and more biocompatible polymers. Despite the superiority of the current DES compared to BMS, a subset of patients still receives BMS...
September 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28940596/the-prescription-of-antiplatelet-medication-in-a-very-elderly-population-an-observational-study-in-15%C3%A2-141-ambulatory-subjects
#17
Patrick Manckoundia, Jean-Baptiste Buzens, Rachid Mahmoudi, Philippe d'Athis, Isabelle Martin, Caroline Laborde, Didier Menu, Alain Putot
OBJECTIVE: Despite the frequent use of antiplatelet medication (AM) in the elderly patients, very few studies have investigated its prescription. We describe AM prescription through retrospective study in ambulatory elderly patients. METHOD: All subjects aged over 80 years with a medical prescription delivered in March 2015 and affiliated to the Mutualité Sociale Agricole de Bourgogne. Subjects with prescriptions for AM were compared with those without. RESULTS: A total of 15 141 ambulatory elderly patients (83-89 years, 61...
September 21, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28940026/coronary-ct-angiography-derived-fractional-flow-reserve-the-game-changer-in-noninvasive-testing
#18
REVIEW
Bjarne Linde Nørgaard, Jesper Møller Jensen, Philipp Blanke, Niels Peter Sand, Mark Rabbat, Jonathon Leipsic
To summarize the scientific basis of CT derived fractional flow reserve (FFRCT) and present an updated review on the evidence from clinical trials and real-world observational data RECENT FINDINGS: In prospective multicenter studies of patients with stable coronary artery disease (CAD), FFRCT showed high diagnostic performance. More recently, FFRCT has advanced to the realm of clinical utility and real-world clinical practice with emerging data showing that FFRCT when compared to standard care is efficient in safely reducing downstream utilization of invasive coronary angiography (ICA), and costs, as well as improving the diagnostic yield of ICA...
September 22, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28939213/cytokines-and-microrna-in-coronary-artery-disease
#19
Hamed Mirzaei, Gordon A Ferns, Amir Avan, Majid G Mobarhan
Cardiovascular disease (CVD) is a major health problem globally. The high incidence and case fatality of CVD are, to a large extent, a consequence of its late diagnosis and lack of highly sensitive and specific markers. Only a very small number of biomarkers, such as troponin, detect late disease. There is some evidence of an association and dysregulation between specific cytokines in the pathogenesis of CVD. These molecules are involved in inflammatory and immune mechanisms associated with atherogenesis. Several molecular/cellular pathways that include STAT, MAPK, and SMAD are modulated by cytokines...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28939174/ventricular-repolarization-alterations-in-women-with-angina-pectoris-and-suspected-coronary-microvascular-dysfunction
#20
Nynne Dose, Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Christina Ellervik, Peter R Hansen, Jørgen K Kanters, Eva Prescott, Jens Kastrup, Ida Gustafsson, Henrik Steen Hansen
OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD. METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch...
August 17, 2017: Journal of Electrocardiology
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