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Cardiac risk assessment

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https://www.readbyqxmd.com/read/29932892/can-copeptin-and-troponin-t-ratio-predict-final-infarct-size-and-myocardial-salvage-index-in-patients-with-st-elevation-myocardial-infarction-a-sub-study-of-the-danami-3-trial
#1
Ásthildur Árnadóttir, Mikkel Schoos, Jacob Lønborg, Kiril Ahtarovski, Henning Kelbæk, Steffen Helqvist, Dan Høfsten, Peter Clemmensen, Thomas Engstrøm, Lars Nepper-Christensen, Niels Vejlstrup, Lars Køber, Kasper Iversen
BACKGROUND: Primary percutaneous coronary intervention (pPCI) is recommended in patients presenting with ST-elevation myocardial infarction (STEMI) within <12 h of symptom onset. However, patients-reported symptom duration is not always reliable. Cardiac specific troponin T (cTnT) and the endogenous stress marker copeptin have different temporal release patterns for myocardial infarction MI. We hypothesized that copeptin/troponin-ratio is associated to the duration of coronary occlusion and therefore inversely proportional to myocardial salvage...
June 19, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29932311/rationale-and-design-of-a-multicentre-randomized-placebo-controlled-trial-of-mirabegron-a-beta3-adrenergic-receptor-agonist-on-left-ventricular-mass-and-diastolic-function-in-patients-with-structural-heart-disease-beta3-left-ventricular-hypertrophy-beta3-lvh
#2
Anne-Catherine Pouleur, Stefan Anker, Dulce Brito, Oana Brosteanu, Dirk Hasenclever, Barbara Casadei, Frank Edelmann, Gerasimos Filippatos, Damien Gruson, Ignatios Ikonomidis, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Bernhard L Gerber, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Jean-Luc Balligand
AIMS: Progressive left ventricular (LV) remodelling with cardiac myocyte hypertrophy, myocardial fibrosis, and endothelial dysfunction plays a key role in the onset and progression of heart failure with preserved ejection fraction. The Beta3-LVH trial will test the hypothesis that the β3 adrenergic receptor agonist mirabegron will improve LV hypertrophy and diastolic function in patients with hypertensive structural heart disease at high risk for developing heart failure with preserved ejection fraction...
June 22, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29931225/trpv4-increases-cardiomyocyte-calcium-cycling-and-contractility-yet-contributes-to-damage-in-the-aged-heart-following-hypoosmotic-stress
#3
John L Jones, Deborah Peana, Adam B Veteto, Michelle D Lambert, Zahra Nourian, Natalia G Karasseva, Michael A Hill, Brian R Lindman, Christopher P Baines, Maike Krenz, Timothy L Domeier
Aims: Cardiomyocyte Ca2+ homeostasis is altered with aging via poorly-understood mechanisms. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an osmotically-activated Ca2+ channel and there is limited information on the role of TRPV4 in cardiomyocytes. Our data show that TRPV4 protein expression increases in cardiomyocytes of the aged heart. The objective of this study was to examine the role of TRPV4 in cardiomyocyte Ca2+ homeostasis following hypoosmotic stress and to assess the contribution of TRPV4 to cardiac contractility and tissue damage following ischemia-reperfusion (I/R), a pathological condition associated with cardiomyocyte osmotic stress...
June 20, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29930944/scientific-contributions-of-population-based-studies-to-cardiovascular-epidemiology-in-the-gwas-era
#4
Wolfgang Lieb, Ramachandran S Vasan
Longitudinal, well phenotyped, population-based cohort studies offer unique research opportunities in the context of genome-wide association studies (GWAS), including GWAS for new-onset (incident) cardiovascular disease (CVD) events, the assessment of gene x lifestyle interactions, and evaluating the incremental predictive utility of genetic information in apparently healthy individuals. Furthermore, comprehensively phenotyped community-dwelling samples have contributed to GWAS of numerous traits that reflect normal organ function (e...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29929955/accuracy-of-a-novel-handheld-wireless-platform-for-detection-of-cardiac-dysfunction-in-anthracycline-exposed-survivors-of-childhood-cancer
#5
Saro H Armenian, Derek Rinderknecht, Kaylene Au, Lanie Lindenfeld, George Mills, Aida Siyahian, Claudia Herrera, Karla Wilson, Kalyanasundaram Venkataraman, Kristen Mascarenhas, Peyman Tavallali, Marianne Razavi, Niema Pahlevan, Jon Detterich, Smita Bhatia, Morteza Gharib
Purpose: Childhood cancer survivors are at risk for anthracycline-related cardiac dysfunction, often developing at a time when they are least engaged in long-term survivorship care. New paradigms in survivorship care and chronic disease screening are needed in this population. We compared the accuracy of a novel handheld mHealth platform (Vivio) as well as echocardiography for assessment of cardiac function [left ventricular ejection fraction (EF)] in childhood cancer survivors with cardiac magnetic resonance (CMR) imaging (reference)...
June 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29929931/two-year-cardiac-mortality-after-mitraclip-treatment-of-functional-mitral-regurgitation-in-ischemic-and-non-ischemic-dilated-cardiomyopathy
#6
Cosmo Godino, Andrea Scotti, Maurizio Taramasso, Marianna Adamo, Marco Russo, Mauro Chiarito, Francesco Melillo, Alessandro Beneduce, Carlo Andrea Pivato, Luca Arrigoni, Evelina Toscano, Anna Salerno, Alberto Cappelletti, Valeria Magni, Stefano Stella, Gabriele Fragasso, Matteo Montorfano, Eustachio Agricola, Federica Ettori, Alberto Margonato, Francesco Maisano, Antonio Colombo
BACKGROUND: MitraClip implantation has evolved as a new tool for treatment of inoperable or high-risk patients with severe functional mitral regurgitation (FMR) due to dilated cardiomyopathy (DCM). Limited data are available regarding MitraClip outcomes comparing patients with ischemic and non-ischemic DCM. METHODS: From 2008 to 2016, 314 patients received MitraClip for FMR at four institutions: Brescia, Zurich and Milan. Patients were stratified according to MR aetiology in non-ischemic FMR (n = 99) and ischemic FMR (n = 215)...
June 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29929865/mapping-the-gaps-gender-differences-in-preventive-cardiovascular-care-among-managed-care-members-in-four-metropolitan-areas
#7
Chloe E Bird, Michael Manocchia, Brooke Tomblin, Peggy Payne, Mahesh Kulakodlu, Emily Iacolo, Allen M Fremont
BACKGROUND: Prior research documents gender gaps in cardiovascular risk management, with women receiving poorer quality routine care on average, even in managed care systems. Although population health management tools and quality improvement efforts have led to better overall care quality and narrowing of racial/ethnic gaps for a variety of measures, we sought to quantify persistent gender gaps in cardiovascular risk management and to assess the performance of routinely used commercial population health management tools in helping systems narrow gender gaps...
June 1, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29928309/diagnosis-and-outcomes-of-transcatheter-aortic-valve-implantation-in-bicuspid-aortic-valve-stenosis
#8
REVIEW
Sung-Han Yoon, Yoshio Maeno, Hiroyuki Kawamori, Masaki Miyasaka, Takahiro Nomura, Tomoki Ochiai, Shadi Nemanpour, Matthias Raschpichler, Rahul Sharma, Tarun Chakravarty, Raj Makkar
Bicuspid aortic valve is the most common congenital cardiac malformation. Aortic valve replacement is often required in older patients but the surgical risk is often extremely high. As Transcatheter aortic valve implantation (TAVI) is an established therapy for intermediate and high surgical risk patients with symptomatic severe aortic valve stenosis (AS). Advances in technology and knowledge have led to TAVI being used for other pathologies and populations such as bicuspid AS. Recently, the diagnosis and classification of bicuspid aortic valve based on multidetector computed tomography (MDCT) assessment has been proposed, which may have an impact of outcomes after TAVI...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29927869/association-of-aortic-arch-width-assessed-by-noncontrast-cardiac-computed-tomography-with-cardiac-remodeling-cardiac-function-and-atherosclerosis-in-a-japanese-cohort
#9
Huong Nguyen-Thu, Yoshiaki Ohyama, Ayako Taketomi-Takahashi, Tien Nguyen-Cong, Akio Sugimoto, Makito Sato, Hisako Sumiyoshi, Tetsuya Nakamura, Masahiko Kurabayashi, Yoshito Tsushima
PURPOSE: Age-related aortic changes are related to adverse cardiac remodeling and reduced cardiac function. Here, we aim to assess the correlations between aortic arch width (AAW) and left ventricular (LV) remodeling and LV function as well as coronary artery calcification (CAC). MATERIALS AND METHODS: This retrospective study included 194 patients (ages, 67±12 y) who underwent both coronary computed tomography angiography and echocardiography. The AAW is defined as the longest width between the ascending and descending aorta on a transaxial noncontrast coronary computed tomography angiography image at the level of the pulmonary artery bifurcation...
July 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29927460/are-high-flow-arteriovenous-accesses-associated-with-worse-haemodialysis
#10
Ivo Laranjinha, Patrícia Matias, Ana Azevedo, David Navarro, Carina Ferreira, Tiago Amaral, Marco Mendes, Inês Aires, Cristina Jorge, Célia Gil, Anibal Ferreira
INTRODUCTION: An arteriovenous (AV) access flow (Qa) of 400 mL/min is usually sufficient for an effective hemodialysis (HD), but some accesses continue developing and become high flow accesses (HFA). Some authors postulated that an HFA might shift a significant portion of dialyzed blood from the cardiac output, which could decrease HD efficiency and lead to volume overload. OBJECTIVE: The aim of our study was to evaluate if HFA is associated with reduced HD efficiency and/or volume overload in prevalent HD patients...
May 28, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29926901/lactate-lactate-clearance-and-outcome-after-cardiac-arrest-a-post-hoc-analysis-of-the-ttm-trial
#11
J Düring, J Dankiewicz, T Cronberg, C Hassager, J Hovdenes, J Kjaergaard, M Kuiper, N Nielsen, T Pellis, P Stammet, J Vulto, M Wanscher, M Wise, A Åneman, H Friberg
BACKGROUND: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. METHODS: This is a post-hoc analysis of the Target Temperature Management trial in which 950 unconscious patents after out-of-hospital cardiac arrest were randomized to a temperature intervention of 33°C or 36°C. Serial lactate samples during the first 36 hours were collected...
June 21, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29926477/local-anaesthetics-and-regional-anaesthesia-versus-conventional-analgesia-for-preventing-persistent-postoperative-pain-in-adults-and-children
#12
REVIEW
Erica J Weinstein, Jacob L Levene, Marc S Cohen, Doerthe A Andreae, Jerry Y Chao, Matthew Johnson, Charles B Hall, Michael H Andreae
BACKGROUND: Regional anaesthesia may reduce the rate of persistent postoperative pain (PPP), a frequent and debilitating condition. This review was originally published in 2012 and updated in 2017. OBJECTIVES: To compare local anaesthetics and regional anaesthesia versus conventional analgesia for the prevention of PPP beyond three months in adults and children undergoing elective surgery. SEARCH METHODS: We searched CENTRAL, MEDLINE, and Embase to December 2016 without any language restriction...
June 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29925725/cardiac-surgery-using-hypothermic-circulatory-arrest-in-a-case-of-essential-thrombocythemia
#13
Masahide Enomoto, Takeshi Kinoshita, Yasuo Kondo, Tomoaki Suzuki, Tohru Asai
We present the case of a 61-year-old patient with a history of essential thrombocythemia (ET) who was diagnosed as having aortic valve stenosis and dilatation of his ascending aorta. His aortic valve and ascending aorta were replaced under hypothermic circulatory arrest (HCA). No clear guideline exists for preoperative, perioperative, and postoperative management of cardiac surgery using HCA for ET patients. After performing risk assessment, we prescribed preoperative aspirin therapy and postoperative care was planned as usual for cardiovascular surgery in our establishment...
June 21, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29924786/-risk-factors-for-the-development-of-life-threatening-ventricular-arrhythmias-following-surgical-reconstruction-of-the-left-ventricle
#14
E V Rosseĭkin, E E Kobzev, O V Popyl'kova, S S Durmanov, V V Bazylev
Death in patients with postinfarction aneurysms of the left ventricle (LV) is mainly caused by life-threatening ventricular arrhythmias - ventricular tachycardias (VTs) and ventricular fibrillations (VFs). Surgical reconstruction of the LV may potentially lead to disruption of the re-entry mechanism, lying at the basis of ventricular tachyarrhythmias. A series of authors demonstrated high efficacy of such procedures as endocardectomy and radiofrequency ablation of the borderline zone of the LV. But high incidence of relapses, difficulty detecting the localization of VT and performing radiofrequency ablation (RFA), as well as high incidence of spontaneous and induced VTs in patients with postinfarction aneurysms of the LV have preserved dissatisfaction with the currently existing techniques...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29923941/intensive-care-mortality-prognostic-model-for-pediatric-pulmonary-hypertension
#15
Emily Morell Balkin, Matt S Zinter, Satish K Rajagopal, Roberta L Keller, Jeffrey R Fineman, Martina A Steurer
OBJECTIVES: The disease burden and mortality of children with pulmonary hypertension are significantly higher than for the general PICU population. We aimed to develop a risk-adjustment tool predicting PICU mortality for pediatric pulmonary hypertension patients: the Pediatric Index of Pulmonary Hypertension Intensive Care Mortality score. DESIGN: Retrospective analysis of prospectively collected multicenter pediatric critical care data. SETTING: One-hundred forty-three centers submitting data to Virtual Pediatric Systems database between January 1, 2009, and December 31, 2015...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29923938/predictive-factors-for-central-line-associated-bloodstream-infections-in-pediatric-cardiac-surgery-patients-with-chylothorax
#16
Stephanie G Waterhouse, Jeffrey E Vergales, Mark R Conaway, Laura Lee
OBJECTIVES: To assess the prevalence of central line-associated bloodstream infections in pediatric patients with and without chylothorax after cardiac surgery and identify risk factors that predict those patients at highest risk for developing a central line-associated bloodstream infection. DESIGN: Retrospective single-center cohort study. SETTING: A PICU located within a tertiary-care academic pediatric hospital. PATIENTS: All pediatric patients admitted to the PICU after cardiac surgery between 2008 and 2014...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29923530/a-study-on-prevalence-of-depression-and-associated-risk-factors-among-elderly-in-a-rural-block-of-tamil-nadu
#17
M Buvneshkumar, K R John, M Logaraj
Background: Depression among elderly is an important public health problem responsible for considerable morbidity and disability. Causes of depression are multifactorial and often preventable. As there was dearth of community studies in Tamil Nadu, the present study was undertaken. Objectives: The objective of this study is to estimate the prevalence of depression and to assess the factors which are associated with depression among elderly. Methods: A cross-sectional study was done from July 2014 to July 2015 among elderly in Kattankulathur block with a sample size of 690 by cluster sampling method...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29922963/endocrine-treatment-of-aging-transgender-people
#18
REVIEW
Louis J Gooren, Guy T'Sjoen
High quality empirical data assessing morbidity and mortality and cancer incidence among transgender people are almost non-existent. Sex hormone treatment of conditions in older non-transgender people might as yet be taken as the best available analogy to hormone administration to aging transgender persons. Testosterone administration to transgender men carries little risk with regard to cardiovascular disease and cancer. A dose adaptation may be needed in men with a high hematocrit or cardiac insufficiency...
June 19, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29922434/gestational-diabetes-influences-the-expression-of-hypertrophic-genes-in-left-ventricle-of-rat-s-offspring
#19
Elia Saragard Kermani, Zahra Nazari, Mehdi Mehdizadeh, Majid Shahbazi, Mohammad Jafar Golalipour
Objectives: Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats. Materials and Methods: Diabetes was induced in 40 adult Wistar rats by intraperitoneal injection of 45 mg/kg of streptozotocin...
May 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29922179/peripheral-resistance-baroreflex-during-incremental-bicycle-ergometer-exercise-characterization-and-correlation-with-cardiac-baroreflex
#20
Alberto Porta, Vlasta Bari, Beatrice De Maria, Beatrice Cairo, Emanuele Vaini, Mara Malacarne, Massimo Pagani, Daniela Lucini
The arm of the baroreflex (BR) controlling peripheral resistances (PR), labeled as BR of PR (prBR), was characterized through an extension of the cardiac BR (cBR) sequence analysis. The method exploits recordings of skin blood flow (SBF) from the palm of the non-dominant hand via a laser Doppler flowmeter and of arterial pressure (AP) from the middle finger of the same hand via a plethysmographic device. PR was estimated beat-by-beat as the ratio of mean AP to mean SBF computed over the same heart period (HP)...
2018: Frontiers in Physiology
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