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single photon emission computed tomography

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https://www.readbyqxmd.com/read/29782369/neuroimaging-in-epilepsy
#1
Meneka Kaur Sidhu, John S Duncan, Josemir W Sander
PURPOSE OF REVIEW: Epilepsy neuroimaging is important for detecting the seizure onset zone, predicting and preventing deficits from surgery and illuminating mechanisms of epileptogenesis. An aspiration is to integrate imaging and genetic biomarkers to enable personalized epilepsy treatments. RECENT FINDINGS: The ability to detect lesions, particularly focal cortical dysplasia and hippocampal sclerosis, is increased using ultra high-field imaging and postprocessing techniques such as automated volumetry, T2 relaxometry, voxel-based morphometry and surface-based techniques...
May 17, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29780557/pd-nanosheets-with-their-surface-coordinated-by-radioactive-iodide-as-a-high-performance-theranostic-nanoagent-for-orthotopic-hepatocellular-carcinoma-imaging-and-cancer-therapy
#2
Mei Chen, Zhide Guo, Qinghua Chen, Jingping Wei, Jingchao Li, Changrong Shi, Duo Xu, Dawang Zhou, Xianzhong Zhang, Nanfeng Zheng
Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy. However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges. Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of 131 I and 125 I on their surfaces (denoted as 131 I-Pd-PEG or 125 I-Pd-PEG)...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780124/hiv-dementia-with-a-decreased-cardiac-123-i-metaiodobenzylguanidine-uptake-masquerading-as-dementia-with-lewy-bodies
#3
Masanori Kurihara, Takuya Sasaki, Hiroyuki Ishiura, Shoji Tsuji
Cardiac 123 I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient' s parkinsonism. The decreased MIBG uptake was most likely due to postganglionic sympathetic nerve denervation, which can also be caused by HIV...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780044/-effect-of-misregistration-between-spect-and-ct-images-on-attenuation-correction-for-quantitative-bone-spect-imaging
#4
Mika Sakoshi, Norikazu Matsutomo, Tomoaki Yamamoto, Eisuke Sato
PURPOSE: The aim of this study was to evaluate the effect of misregistration between single-photon emission computed tomography (SPECT) and computed tomography (CT) images on bone SPECT. METHODS: We acquired SPECT and CT images of a body phantom filled with bone-equivalent solution and 99m Tc for evaluation of bone SPECT. SPECT images were reconstructed using attenuation correction maps obtained by shifting the attenuation coefficients from non-shifted values (reference)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29778927/evaluation-of-99m-tc-sulfonamide-and-sulfocoumarin-derivatives-for-imaging-carbonic-anhydrase-ix-expression
#5
Misaki Nakai, Jihne Pan, Kuo-Shyan Lin, John R Thompson, Alessio Nocentini, Claudiu T Supuran, Yasuo Nakabayashi, Tim Storr
With the aim to prepare hypoxia tumor imaging agents, technetium(I) and rhenium(I) tricarbonyl complexes with dipyridylamine (L1 = N-{[1-(2,2-dioxido-1,2-benzoxathiin-6-yl)-1H-1,2,3-triazol-4-yl]methyl}-N-(2-pyridinylmethyl)-2-pyridinemethanamine; L3 = N-{[1-[N-(4-aminosulfonylphenyl)]-1H-1,2,3-triazol-4-yl]methyl}-N-(2-pyridinyl-methyl)-2-pyridinemethanamine), and iminodiacetate (H2 L2 = N-{[1-(2,2-dioxido-1,2-benzoxathiin-6-yl)-1H-1,2,3-triazole-4-yl]methyl}-N-(carboxy-methyl)-glycine; H2 L4 = N-{[1-[N-(4-aminosulfonylphenyl)]-1H-1,2,3-triazole-4-yl]methyl}-N-(carboxymethyl)-glycine) ligands appended to sulfonamide or sulfocoumarin carbonic anhydrase inhibitors were synthesized...
April 13, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29778807/-18-f-fluoride-pet-ct-and-99m-tc-mdp-spect-ct-can-detect-bone-cancer-at-early-stage-in-rodents
#6
Christiano R R Alves, Daniele de P Faria, Camila de G Carneiro, Alexandre T Garcez, Vanessa P Gutierrez, Willian das Neves, Ney R de Almeida, Yara Cury, Roger Chammas, Patricia C Brum
Noninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal studies. The present study was designed to evaluate the potential of PET/CT and SPECT/CT as research tools to detect bone cancer in rats...
May 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29777004/development-of-a-novel-spect-tracer-to-image-c-met-expression-in-non-small-cell-lung-cancer-in-a-human-tumor-xenograft
#7
Zhaoguo Han, Yadi Xiao, Kai Wang, Ji Yan, Zunyu Xiao, Fang Fang, Zhongnan Jin, Yang Liu, Xilin Sun, Baozhong Shen
Rationale: Elevated expression of the c-Met receptor plays a crucial role in cancers. In non-small cell lung cancer (NSCLC), aberrant activation of c-Met signaling pathway contributes to tumorigenesis and cancer progression, and may mediate acquired resistance to epidermal growth factor receptor-targeted therapy. c-Met is therefore emerging as a promising therapeutic target for treating NSCLC, and the methods for noninvasive in vivo assessment of c-Met expression will improve NSCLC treatment and diagnosis. Methods: A new peptide-based (cMBP) radiotracer targeting c-Met, 99m Tc-hydrazine nicotinamide (HYNIC)-cMBP, was developed for single photon emission computed tomography (SPECT) imaging...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29774886/-evaluation-of-inflammatory-activity-in-thyroid-associated-ophthalmopathy-by-spect-ct-with-99mtc-dtpa
#8
Dan Liu, Xueliang Xu, Dan Wen, Jia Tan, Chengzhi Jiang
To evaluate the inflammatory activity in thyroid associated ophthalmopathy (TAO) by 99mTc-diethylene triamine pentaaceticacid (99mTc-DTPA) orbital single-photon emission computed tomography (SPECT)/CT.
 Methods: A total of 48 patients were enrolled from Xiangya Hospital of Central South University between October 2016 and March 2017. According to clinical active score (CAS), 93 eyes were divided into a TAO active group (n=72) and a TAO inactive group (n=21). All patients underwent 99mTc-DTPA orbital SPECT/CT examination, and the DTPA uptake in extraocular muscle belly was supposed to be positive...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774458/effects-of-rs591323-on-serotonin-transporter-availability-in-healthy-male-subjects
#9
Kyoungjune Pak, Hyun-Yeol Nam, Seunghyeon Shin, Keunyoung Kim, Myung Jun Lee, Eun-Joo Kim, Jae Meen Lee, Seong-Jang Kim, In Joo Kim
OBJECTIVES: We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls. METHODS: The study population consisted of healthy controls with screening 123 I-FP-CIT single-photon emission computed tomography. Specific binding of 123 I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons...
May 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29774142/comparison-of-mri-and-123-i-fp-cit-spect-for-the-evaluation-of-msa-p-clinical-severity
#10
Miki Nishimori, Yoriko Murata, Hitomi Iwasa, Kana Miyatake, Michiko Tadokoro, Shino Kohsaki, Munenobu Nogami, Norihiko Hamada, Hitoshi Ninomiya, Yasushi Osaki, Hirokazu Furuya, Takuji Yamagami
The aim of the present study was to compare the efficacy of magnetic resonance imaging (MRI) and 123 I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane single photon emission computed tomography (123 I-FP-CIT SPECT) for determining the clinical severity of patients with multiple system atrophy with Parkinsonism (MSA-P). MRI and 123 I-FP-CIT SPECT images from 17 patients with MSA-P as diagnosed using the Unified MSA Rating Scale part IV (UMSARS IV) score were compared. Brain MRI scans were available for all 17 patients and 123 I-FP-CIT SPECT images were available for 12 patients...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29771387/functional-brown-adipose-tissue-and-sympathetic-activity-after-cold-exposure-in-humans-with-type-1-narcolepsy
#11
Lotte Hahn Enevoldsen, Marie Tindborg, Nichlas Lindegaard Hovmand, Christina Christoffersen, Helga Ellingsgaard, Charlotte Suetta, Bente Merete Stallknecht, Poul Joergen Jennum, Andreas Kjær, Steen Gammeltoft
Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy. Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively...
May 15, 2018: Sleep
https://www.readbyqxmd.com/read/29761990/-a-computer-tomography-assisted-method-for-the-automatic-detection-of-region-of-interest-in-dynamic-kidney-images
#12
Xueping Jing, Xiujuan Zheng, Shaoli Song, Kai Liu
Glomerular filtration rate (GFR), which can be estimated by Gates method with dynamic kidney single photon emission computed tomography (SPECT) imaging, is a key indicator of renal function. In this paper, an automatic computer tomography (CT)-assisted detection method of kidney region of interest (ROI) is proposed to achieve the objective and accurate GFR calculation. In this method, the CT coronal projection image and the enhanced SPECT synthetic image are firstly generated and registered together. Then, the kidney ROIs are delineated using a modified level set algorithm...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29761983/-imaging-analysis-of-jaw-defects-reparation-with-antigen-extracted-porcine-cancellous-bone
#13
Xufeng Chen, Lihong Lu, Zhiqiang Feng, Zhongda Yin, Renfa Lai
At present, most of the bone xenograft for clinical application comes from bovine. In recent years, many studies have been done on the clinical application of porcine xenograft bone. The goal of this study was to evaluate the effect of canine mandibular defects reparation with antigen-extracted porcine cancellous bone by imaging examination. Four dogs' bilateral mandibular defects were created, with one side repaired with autologous bone (set as control group) while the other side repaired with antigen-extracted porcine cancellous bone (set as experimental group)...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29756381/myocardial-multilayer-strain-does-not-provide-additional-value-for-detection-of-myocardial-viability-assessed-by-spect-imaging-over-and-beyond-standard-strain
#14
Elisabeth Orloff, Pauline Fournier, Frédéric Bouisset, Thomas Moine, Maxime Cournot, Meyer Elbaz, Didier Carrié, Michel Galinier, Olivier Lairez, Thomas Cognet
BACKGROUND: The aim of this study was to evaluate the value of multilayer strain analysis to the assessment of myocardial viability (MV) through the comparison of both speckle tracking echocardiography and single-photon emission computed tomography (SPECT) imaging. We also intended to determine which segmental longitudinal strain (LS) cutoff value would be optimal to discriminate viable myocardium. METHODS: We included 47 patients (average age: 61 ± 11 years) referred to our cardiac imaging center for MV evaluation...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29751831/intravenous-injection-of-allogeneic-umbilical-cord-derived-multipotent-mesenchymal-stromal-cells-reduces-the-infarct-area-and-ameliorates-cardiac-function-in-a-porcine-model-of-acute-myocardial-infarction
#15
Meikuang Lim, Weiqiang Wang, Lu Liang, Zhi-Bo Han, Zongjin Li, Jie Geng, Meng Zhao, Honghong Jia, Jie Feng, Zhe Wei, Baoquan Song, Jiemin Zhang, Jun Li, Tianwen Liu, Fan Wang, Ting Li, Jianming Li, Yihu Fang, Jianhua Gao, Zhongchao Han
BACKGROUND: Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injection of allogeneic umbilical cord (UC) MSCs in preclinical models of porcine myocardial infarction. METHODS: Different dosages of allogeneic UC-MSCs or the vehicle [phosphate-buffered saline (PBS)] were delivered intravenously into an acute myocardial infarction (AMI) porcine model twice after coronary ligation...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29748936/semi-quantitative-dopamine-transporter-standardized-uptake-value-in-comparison-with-conventional-specific-binding-ratio-in-123i-fp-cit-single-photon-emission-computed-tomography-datscan
#16
Yuichi Wakabayashi, Ryuichi Takahashi, Tomonori Kanda, Feibi Zeng, Munenobu Nogami, Kazunari Ishii, Takamichi Murakami
PURPOSE: We developed a new analytical method to quantify the dopamine transporter (DAT) radiation dose in the striatum on [123 I] FP-CIT single-photon emission computed tomography (SPECT). This method is based on the dopamine transporter standardized uptake value (DaTSUV). The purpose of this study was to compare DaTSUV with the classical specific binding ratio (SBR) in the discrimination of dopaminergic neurodegenerative diseases (dNDD) from non-dNDD. METHOD: Seventy-seven consecutive patients who underwent DaTscan were included...
May 10, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29748311/radiotracer-imaging-allows-for-noninvasive-detection-and-quantification-of-abnormalities-in-angiosome-foot-perfusion-in-diabetic-patients-with-critical-limb-ischemia-and-nonhealing-wounds
#17
Jessica L Alvelo, Xenophon Papademetris, Carlos Mena-Hurtado, Sangchoon Jeon, Bauer E Sumpio, Albert J Sinusas, Mitchel R Stacy
BACKGROUND: Single photon emission computed tomography (SPECT)/computed tomography (CT) imaging allows for assessment of skeletal muscle microvascular perfusion but has not been quantitatively assessed in angiosomes, or 3-dimensional vascular territories, of the foot. This study assessed and compared resting angiosome foot perfusion between healthy subjects and diabetic patients with critical limb ischemia (CLI). Additionally, the relationship between SPECT/CT imaging and the ankle-brachial index-a standard tool for evaluating peripheral artery disease-was assessed...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29745512/-application-of-%C3%AE-imaging-in-chromatographic-separation-and-protein-molecular-site-density-determination
#18
Jinhe Zhang, Quhuan Li, Yingchen Ling, Jianqiu Zhong, Jilin Yin, Hao Xu
We in this study measured the site density of E-selectin in order to explore the practical pliability using radionuclide labeling method and γ-imaging of single photon emission computer tomography (SPECT). This method required labeling of antibody with 125 I using Indogen method and binding of the labeled antibody to E-selectin. Labeled E-selectin was separated and purified in a Sephadex G25 column. The different fractions of the eluants were imaged, analyzed and quantified with SPECT method. For measuring the saturation curve of E-selectin, 130 μL of E-selectin solution with different concentrations were added in a 48-well plate and incubated overnight at 4℃...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744803/prediction-of-future-weight-change-with-the-dopamine-transporter
#19
Kyoungjune Pak, Keunyoung Kim, Myung Jun Lee, Jae Meen Lee, Bum Soo Kim, Seong-Jang Kim, In Joo Kim
The brain plays a critical role in controlling and inhibiting pre-potent responses to foods. We investigated the predictive value of dopamine transporter (DAT) availability in the striatum of healthy subjects using 123 I-FP-CIT single-photon emission computed tomography (SPECT). In total, 84 participants with available data on their weight for the 60 months after SPECT were included. Specific binding of 123 I-FP-CIT to DAT was calculated using region-of-interest analysis, and the putamen-to-caudate nucleus ratio (PCR) was determined...
May 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29743901/effect-of-nicorandil-administration-on-myocardial-microcirculation-during-primary-percutaneous-coronary-intervention-in-patients-with-acute-myocardial-infarction
#20
Chunguang Feng, Bing Han, Yi Liu, Lulu Wang, Dongdong Niu, Ming Lou, Cunzhi Lu
Introduction: Prevention of the no-reflow phenomenon has a crucial role in primary percutaneous coronary intervention (P-PCI) procedures. Aim: To assess the effects of early intracoronary administration of nicorandil (NIC) during P-PCI on myocardial microcirculation in patients with acute myocardial infarction (AMI). Material and methods: A total of 120 patients with first acute anterior wall ST segment elevation myocardial infarction who underwent P-PCI were randomly divided into two groups: the NIC group (A, n = 60) and the placebo group (B, n = 60)...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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