Alexander R Goldberg, Athanassios Dovas, Daniela Torres, Sohani Das Sharma, Angeliki Mela, Edward M Merricks, Markel Olabarria, Leila Abrishami Shokooh, Hanzhi T Zhao, Corina Kotidis, Peter Calvaresi, Ashwin Viswanathan, Matei A Banu, Aida Razavilar, Tejaswi D Sudhakar, Ankita Saxena, Cole Chokran, Nelson Humala, Aayushi Mahajan, Weihao Xu, Jordan B Metz, Cady Chen, Eric A Bushong, Daniela Boassa, Mark H Ellisman, Elizabeth M C Hillman, Guy M McKhann, Brian J A Gill, Steven S Rosenfeld, Catherine A Schevon, Jeffrey N Bruce, Peter A Sims, Darcy S Peterka, Peter Canoll
Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are increasingly appreciated as important reactive components of the glioma microenvironment, due to their role in causing hallmark glioma symptoms, such as cognitive deficits and seizures, as well as their potential ability to drive glioma progression. Separately, mTOR signaling has been shown to have pleiotropic effects in the brain tumor microenvironment, including regulation of neuronal hyperexcitability...
January 21, 2024: bioRxiv