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JOURNAL ARTICLE
Angela Lozano-Ochoa, Verónica Roldán Galiacho, Leyre Cristina Jiménez Ros, Raquel Pérez Garay, Juan Carlos García-Ruiz
No abstract text is available yet for this article.
April 10, 2024: Hematology, Transfusion and Cell Therapy
#22
JOURNAL ARTICLE
Masato Saitoh, Takemi Kudo, Takao Watanabe
BACKGROUND: Among venous thromboembolism, pulmonary thromboembolism (PTE) is one of the most serious postoperative complications. Deep venous thrombosis (DVT) is the main cause. Considering the unknown prevalence of DVT and PTE in the postoperative period of cardiovascular surgery in Japan, we investigated the incidence in consecutive patients who underwent cardiovascular surgery. METHODS: A total of 225 patients who underwent cardiovascular surgery at four hospitals consented to participate in the study...
April 13, 2024: Asian Cardiovascular & Thoracic Annals
#23
JOURNAL ARTICLE
Frederik F Lau, Marianne Agerskov, Anna N W Thusholdt, Jakob Højlund, Christian S Meyhoff, Øivind Jans, Nicolai B Foss
STUDY OBJECTIVE: Evidence for red blood cell (RBC) transfusion thresholds in the intraoperative setting is limited, and current perioperative recommendations may not correspond with individual intraoperative physiological demands. Hemodynamics relevant for the decision to transfuse may include peripheral perfusion index (PPI). The objective of this prospective study was to assess the associations of PPI and hemoglobin levels with the risk of postoperative morbidity and mortality. DESIGN: Multicenter cohort study...
April 12, 2024: Journal of Clinical Anesthesia
#24
JOURNAL ARTICLE
Maximilian Klink, Matthias Felber, Ulrike Zeilhofer, Mathias Hauri-Hohl, Markus Schmugge, Daniel Drozdov, Tayfun Güngör
BACKGROUND: Hematopoietic cell transplantation (HCT) is an established curative therapy for transfusion-dependent thalassemia (TDT) and sickle cell disease (SCD). The latest American Society of Hematology guidelines recommend myeloablative preparative regimen in patients under 18 years of age. PROCEDURE: The objective was to demonstrate safety and efficacy of a reduced intensity conditioning (RIC) regimen including high-dose fludarabine, anti-thymocyte globulin, and targeted busulfan as a single alkylator to sub-myeloablative exposures...
April 12, 2024: Pediatric Blood & Cancer
#25
Maria Suprunowicz, Katarzyna Marcinkiewicz, Elżbieta Leszczyńska, Anna Krętowska-Grunwald, Marcin Płonowski, Mariola Tałałaj, Łucja Dakowicz, Maryna Krawczuk-Rybak, Małgorzata Sawicka-Żukowska
Methemoglobinemia is a potentially life-threatening, rare condition in which the oxygen-carrying capacity of hemoglobin is diminished. We present the case of a 3-year-old boy treated for T-cell acute lymphoblastic leukemia (T-ALL) who developed methemoglobinemia (MetHb 57.1%) as a side effect of ifosfamide administration. Due to his critical condition, the patient was transferred to the intensive care unit (ICU). The therapy included methylene blue administration, an exchange transfusion, catecholamine infusion, and steroids...
March 28, 2024: International Journal of Molecular Sciences
#26
JOURNAL ARTICLE
Elizabeth Oladoyin Agboluaje, Shuolin Cui, Neil J Grimsey, May P Xiong
Patients with β-thalassemia and sickle cell disease often rely on blood transfusions which can lead to hemochromatosis and chronic oxidative stress in cells and tissues. Deferoxamine (DFO) is clinically approved to treat hemochromatosis but is suboptimal to patients due to its poor pharmacokinetics which requires long-term infusion regimens. Although the oral route is preferable, DFO has limited oral bioavailability. Studies have shown that hyaluronic acid (HA) and bile acid (BA) can enhance the oral absorption of poorly absorbed drugs...
April 12, 2024: AAPS Journal
#27
JOURNAL ARTICLE
Thyago R Cardim-Pires, Aurélie de Rus Jacquet, Francesca Cicchetti
Our limited understanding of complex neurodegenerative disorders has held us back on the development of efficient therapies. While several approaches are currently being considered, it is still unclear what will be most successful. Among the latest and more novel ideas, the concept of blood or plasma transfusion from young healthy donors to diseased patients is gaining momentum and attracting attention beyond the scientific arena. While young or healthy blood is enriched with protective and restorative components, blood from older subjects may accumulate neurotoxic agents or be impoverished of beneficial factors...
April 12, 2024: Journal of Neurology
#28
JOURNAL ARTICLE
Gil Cunha De Santis, Lorena Costa, Denise Menezes Brunetta, Mariana Munari Magnus, Bruno Deltreggia Benites, Roseny Dos Reis Rodrigues, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi
Anemia is a pathological condition in which the hemoglobin and red blood cell mass decrease; it is mainly defined by the concentration of hemoglobin in the blood. The World Health Organization guidelines establish specific values to define anemia in different population groups. Early detection of anemia can also be a valuable indicator of underlying medical conditions. Clinical studies have explored the relationship between perioperative anemia and morbidity, highlighting the need for more judicious therapeutic strategies, such as the use of Patient Blood Management, which aims to prevent and treat anemia in a personalized and effective way...
March 21, 2024: Hematology, Transfusion and Cell Therapy
#29
JOURNAL ARTICLE
Bryan D Springer, Carlos Higuera-Rueda, Brian de Beaubien, Kevin Warner, Andrew Glassman, Hari Parvataneni, Nicolas Piuzzi
INTRODUCTION: Systemic intravenous antimicrobials yield poor outcomes during the treatment of periprosthetic joint infection because systemic therapy is unable to obtain the minimum biofilm eradication concentration. Therefore, this study evaluated the safety of a novel method of optimized local delivery of intra-articular antibiotics (IAA) when compared to two-stage exchange arthroplasty. METHODS: This was a Phase II, multicenter, prospective randomized clinical trial of the safety of a seven-day two-stage exchange arthroplasty with IAA irrigation compared to a standard two-stage exchange...
April 9, 2024: Journal of Arthroplasty
#30
JOURNAL ARTICLE
Alexander Yelak, Anat From, Oded Gilad, Dafna Brik Simon, Shiri Rubin, Miriam Cohen, Gil Amarilyo, Carina Levin, Doua Bakry, Shai Izraeli, Hannah Tamary, Joanne Yacobovich, Orna Steinberg-Shemer
Patients with immune thrombocytopenia (ITP) usually present with minor mucocutaneous bleeding. Corpus luteum hemorrhage (CLH) is generally asymptomatic but may, rarely, lead to severe intraperitoneal bleeding, mostly in patients with coagulation disorders. CLH causing intraperitoneal bleeding has only been described in few individuals with ITP. The objective of this retrospective observational study was to assess the clinical course and incidence of symptomatic CLH in adolescent females with newly diagnosed or chronic ITP...
April 11, 2024: European Journal of Pediatrics
#31
JOURNAL ARTICLE
Sidika Gülkan Özkan, Ali Kimiaei, Seyedehtina Safaei, Meral Sönmezoğlu, Hasan Atilla Özkan
Introduction Despite the development of modern antibiotic and antifungal therapies, neutropenic infections remain life-threatening. Granulocyte transfusion (GTX) is a less frequently used treatment modality in patients with refractory neutropenic infections. The role of donor GTX remains controversial, partly because of the lack of proper clinical trials. This study aimed to contribute to the literature by evaluating the efficacy and side effects of granulocyte transfusions in our center. Methods Eight febrile neutropenic patients with confirmed infections received granulocyte transfusions from ABO-compatible related and unrelated donors...
March 2024: Curēus
#32
MULTICENTER STUDY
Marianna Adamo, Giulio Russo, Matteo Pagnesi, Edoardo Pancaldi, Hannes Alessandrini, Martin Andreas, Luigi P Badano, Daniel Braun, Kim A Connelly, Paolo Denti, Rodrigo Estevez-Loureiro, Neil Fam, Mara Gavazzoni, Rebecca T Hahn, Claudia Harr, Joerg Hausleiter, Dominique Himbert, Daniel Kalbacher, Edwin Ho, Azeem Latib, Edith Lubos, Sebastian Ludwig, Laura Lupi, Philipp Lurz, Vanessa Monivas, Georg Nickenig, Daniela Pedicino, Giovanni Pedrazzini, Alberto Pozzoli, Denise Pires Marafon, Roberta Pastorino, Fabien Praz, Joseph Rodes-Cabau, Christian Besler, Anne Rebecca Schöber, Joachim Schofer, Andrea Scotti, Kerstin Piayda, Horst Sievert, Gilbert H L Tang, Alessandro Sticchi, David Messika-Zeitoun, Holger Thiele, Florian Schlotter, Ralph Stephan von Bardeleben, John Webb, Julien Dreyfus, Stephan Windecker, Martin Leon, Francesco Maisano, Marco Metra, Maurizio Taramasso
BACKGROUND: Data on the prognostic role of the TRI-SCORE in patients undergoing transcatheter tricuspid valve intervention (TTVI) are limited. OBJECTIVES: The aim of this study was to evaluate the performance of the TRI-SCORE in predicting outcomes of patients undergoing TTVI. METHODS: TriValve (Transcatheter Tricuspid Valve Therapies) is a large multicenter multinational registry including patients undergoing TTVI. The TRI-SCORE is a risk model recently proposed to predict in-hospital mortality after tricuspid valve surgery...
April 8, 2024: JACC. Cardiovascular Interventions
#33
JOURNAL ARTICLE
Milanka Milosavić, Marko Lilić, Zorana Andrić
BACKROUND AND OBJECTIVES: Blood transfusion therapy is vital for many patient groups. They can cause many complications, and the development of anti-red blood cell (RBC) antibodies is of significant importance. Molecules of class II human leucocyte antigens (HLA) are one of the several factors that influence antibody development in patients. MATERIALS AND METHODS: In this study, we investigated 108 patients who developed antibodies against different erythrocyte antigens and 115 patients on multiple transfusion therapies who did not develop anti-RBC antibodies...
April 10, 2024: Vox Sanguinis
#34
Alexandra Bonmatí-Santané, Roberto Céspedes López, Jehimy Jean Alvarez Saltos, Jordi Calabia Martínez, Cristina Noboa Paez, Jordi Piedra Sánchez, Natalia Visa Figueredo, Anna Maroto González
Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis...
2024: Women's health reports
#35
JOURNAL ARTICLE
Madelief Bolscher, Stephanie C E Koster, Matty Koopmans, Jelle L G Haitsma Mulier, Lennie P G Derde, Nicole P Juffermans
BACKGROUND: Anemia is a hallmark of critical illness, which is largely inflammatory driven. We hypothesized that the use of anti-inflammatory agents limits the development of anemia and reduces the need for red blood cell (RBC) transfusions in patients with a hyper-inflammatory condition due to COVID-19. METHODS: An observational cohort (n = 772) and a validation cohort (a subset of REMAP-CAP, n = 119) of critically ill patients with hypoxemic respiratory failure due to COVID-19 were analyzed, who either received no treatment, received steroids or received steroids plus IL-6 blocking agents...
April 9, 2024: Critical Care: the Official Journal of the Critical Care Forum
#36
JOURNAL ARTICLE
Michaël Levy, Jérôme Naudin, Guillaume Geslain, Arielle Maroni, Bérengère Koehl, Fleur Le Bourgeois, Géraldine Poncelet, Maryline Chomton, Anna Deho, Sébastien Julliand, Stéphane Dauger, Julie Sommet
BACKGROUND: Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvement of care. However, children with SCD can become critically ill and require admission in Pediatric Intensive Care Units (PICU). The purpose of this study was to describe the epidemiology of children with SCD admitted to PICU for acute crisis and to identify factors associated with adverse outcome (AO)...
April 10, 2024: Annals of Intensive Care
#37
REVIEW
Michael J Hochman, Amy E DeZern
Higher-risk myelodysplastic syndromes (HR-MDS) are clonal myeloid neoplasms that cause life-limiting complications from severe cytopenias and leukemic transformation. Efforts to better classify, prognosticate, and assess therapeutic responses in HR-MDS have resulted in publication of new clinical tools in the last several years. Given limited current treatment options and suboptimal outcomes, HR-MDS stands to benefit from the study of investigational agents.Higher-risk myelodysplastic syndromes (HR-MDS) are a heterogenous group of clonal myeloid-lineage malignancies often characterized by high-risk genetic lesions, increased blood transfusion needs, constitutional symptoms, elevated risk of progression to acute myeloid leukemia (AML), and therapeutic need for allogeneic bone marrow transplantation...
March 18, 2024: Clinical Lymphoma, Myeloma & Leukemia
#38
JOURNAL ARTICLE
Ellen Zhang, Zain M Virk, Josanna Rodriguez-Lopez, Hanny Al-Samkari
Hereditary hemorrhagic telangiectasia (HHT) is the second-most-common inherited bleeding disorder worldwide and remains without approved therapies. HHT causes serious mucosal bleeding resulting in severe iron deficiency anemia, major psychosocial complications, and visceral arteriovenous malformations in brain, lung, and liver that can cause life-threatening hemorrhagic complications. No study has examined the relative morbidity of HHT and von Willebrand disease (VWD), the most common inherited bleeding disorders in women...
April 9, 2024: Blood Advances
#39
JOURNAL ARTICLE
Régis Peffault de Latour, Morag Griffin, Richard J Kelly, Jeff Szer, Carlos de Castro, Regina Horneff, Lisa Tan, Michael M Yeh, Jens Peter Panse
Patients with paroxysmal nocturnal hemoglobinuria (PNH) experience complement-mediated intravascular hemolysis leading to anemia, fatigue, and potentially life-threatening thrombotic complications. Pegcetacoplan, a C3 inhibitor, demonstrated sustained improvements in hematological and clinical parameters in the Phase 3 PEGASUS trial in patients with PNH who remained anemic despite C5 inhibitor therapy. The current post-hoc analysis describes 26 hemolysis adverse events (AEs) experienced in 19 patients during pegcetacoplan therapy in PEGASUS and baseline patient characteristics potentially associated with increased hemolysis risk...
April 9, 2024: Blood Advances
#40
JOURNAL ARTICLE
Rachel C Murphy, Tyler W Johnson, Thomas J Mack, Rachel E Burke, Nicholas P Damiano, Laura Heger, Nicholas Minner, Emily German, Angela Wilson, Michael G Mount, Brian C Thurston, Caleb J Mentzer
BACKGROUND: Blood product component-only resuscitation (CORe) has been the standard of practice in both military and civilian trauma care with a 1:1:1 ratio used in attempt to recreate whole blood (WB) until recent data demonstrated WB to confer a survival advantage, leading to the emergence of WB as the contemporary resuscitation strategy of choice. Little is known about the cost and waste reduction associated with WB vs CORe. METHODS: This study is a retrospective single-center review of adult trauma patients admitted to a community trauma center who received WB or CORe as part of their massive transfusion protocol (MTP) resuscitation from 2017 to 2021...
April 9, 2024: American Surgeon
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