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https://www.readbyqxmd.com/read/29906300/new-treatment-criteria-for-preterm-hyperbilirubinemic-infants-in-japan
#1
Ichiro Morioka
In 1992, Kobe University proposed treatment criteria for hyperbilirubinemic newborns using total serum bilirubin and serum unbound bilirubin reference values. In the last decade, chronic bilirubin encephalopathy has found to develop in preterm infants in Japan because it can now be clinically diagnosed based on an abnormal signal of the globus pallidus in T2-weighted magnetic resonance imaging and abnormal findings of the auditory brainstem response with or without apparent hearing loss, along with physical findings of kinetic disorders with athetosis...
June 15, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29905956/population-pharmacokinetic-pharmacodynamic-analyses-of-avatrombopag-in-patients-with-chronic-liver-disease-and-optimal-dose-adjustment-guide-with-concomitantly-administered-cyp3a-and-cyp2c9-inhibitors
#2
Maiko Nomoto, Jim Ferry, Ziad Hussein
Avatrombopag, a c-Mpl agonist, has been developed to provide an alternative therapy to standard platelet transfusion care for the treatment of thrombocytopenia. The main objectives of this article were to describe the pharmacokinetics (PK) of avatrombopag, to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationship between plasma avatrombopag concentrations and platelet count, and to identify potential intrinsic and extrinsic factors affecting PK or PK/PD in patients with chronic liver disease (CLD)...
June 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29905937/iron-overload-in-patients-with-myelodysplastic-syndromes-an-updated-overview
#3
REVIEW
Nour M Moukalled, Fuad A El Rassi, Sally N Temraz, Ali T Taher
Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by a broad clinical spectrum related to ineffective hematopoiesis leading to unilineage or multilineage cytopenias, with a high propensity for transformation to acute myeloid leukemia. Iron overload has been recently identified as one of the important conditions complicating the management of these diverse disorders. The accumulation of iron is mainly related to chronic transfusions; however, evidence suggests a possible role for ineffective erythropoiesis and increased intestinal absorption of iron, related to altered hepcidin and growth differentiation factor-15 levels in the development of hemosiderosis in patients with MDS...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29904950/optimizing-management-of-deferasirox-therapy-for-patients-with-transfusion-dependent-thalassaemia-and-lower-risk-myelodysplastic-syndromes
#4
REVIEW
Antonis Kattamis, Yesim Aydinok, Ali Taher
Effective iron chelation therapy is an important part of treatment in patients with transfusion-dependent thalassaemia and lower-risk myelodysplastic syndromes (MDS). Key strategies for optimizing iron chelation therapy include ensuring good adherence and preventing and managing adverse events (AEs). Good adherence to iron chelation therapy with deferoxamine and deferasirox has been linked to improved survival and/or reductions in complications related to iron overload; however, maintaining good adherence to iron chelators can be challenging...
June 14, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29904575/recent-advances-in-transfusions-in-neonates-infants
#5
REVIEW
Ruchika Goel, Cassandra D Josephson
Transfusions of red blood cells (RBCs), platelets, and plasma are critical therapies for infants and neonates (particularly preterm neonates) in the neonatal intensive care unit, who are the most frequently transfused subpopulation across all ages. Although traditionally a significant gap has existed between the blood utilization and the evidence base essential to adequately guide transfusion practices in infants and neonates, pediatric transfusion medicine is evolving from infancy and gradually coming of age...
2018: F1000Research
https://www.readbyqxmd.com/read/29903928/antibody-with-infinite-affinity-for-in-vivo-tracking-of-genetically-engineered-lymphocytes
#6
Simone Krebs, Afruja Ahad, Lukas Carter, Justin Eyquem, Christian Brand, Meghan Bell, Vladimir Ponomarev, Thomas Reiner, Claude F Meares, Stephen Gottschalk, Michel Sadelain, Steven M Larson, Wolfgang Andreas Weber
There remains an urgent need for the non-invasive tracking of transfused chimeric antigen receptor (CAR) T cells to determine their biodistribution, viability, expansion, and anti-tumor functionality. 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) antibody reporter 1 (DAbR1) comprises a single-chain fragment of the anti-lanthanoid-DOTA antibody 2D12.5/G54C fused to the human CD4-transmembrane domain and binds irreversibly to lanthanoid-(S)-2-(4-acrylamidobenzyl)-DOTA (AABD). The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects...
June 14, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29902448/postponing-early-intrauterine-transfusion-with-intravenous-immunoglobulin-treatment-the-petit-study-on-severe-hemolytic-disease-of-the-fetus-and-newborn
#7
Carolien Zwiers, Johanna G van der Bom, Inge L van Kamp, Nan Van Geloven, Enrico Lopriore, John Smoleniec, Roland Devlieger, Pauline E Sim, Marie Anne Ledingham, Eleonor Tiblad, Kenneth J Moise, Karl-Philip Gloning, Mark D Kilby, Timothy G Overton, Ditte S Jørgensen, Katrine V Schou, Bettina Paek, Martin Walker, Emma Parry, Dick Oepkes, Masja de Haas
BACKGROUND: Intrauterine transfusion for severe alloimmunization in pregnancy performed before 20 weeks' gestation is associated with a higher fetal death rate. Intravenous immunoglobulins may prevent hemolysis and could therefore be a non-invasive alternative for early transfusions. OBJECTIVE(S): We evaluated whether maternal treatment with intravenous immunoglobulins defers the development of severe fetal anemia and its consequences in a retrospective cohort to which 12 fetal therapy centers contributed...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29902156/hypertriglyceridemia-thalassemia-syndrome
#8
Mili Jain, Wahid Ali, Brijendra Bahadur Singh, Nishant Verma, Ashutosh Kumar
BACKGROUND: Hypertriglyceridemia thalassemia syndrome is a rare entity with an unknown pathogenetic link. CASE PRESENTATION: We report a case of an 8-month-old female with thalassemia major and increased triglyceride (TG) levels. The clinical features were as in classical thalassemia except for a white discoloration of the plasma. After exclusion of familial triglyceridemia and secondary causes (hypothyroidism, nephrotic syndrome, drugs etc.), a diagnosis of hypertriglyceridemia thalassemia syndrome was made...
June 14, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29902097/clinical-consequences-of-iron-overload-in-patients-with-myelodysplastic-syndromes-the-case-for-iron-chelation-therapy
#9
Jamile M Shammo, Rami S Komrokji
Patients with myelodysplastic syndromes (MDS) are at increased risk of iron overload due to ineffective erythropoiesis and chronic transfusion therapy. The clinical consequences of iron overload include cardiac and/or hepatic failure, endocrinopathies, and infection risk. Areas covered: Iron chelation therapy (ICT) can help remove excess iron and ultimately reduce the clinical consequences of iron overload. The authors reviewed recent (last five years) English-language articles from PubMed on the topic of iron overload-related complications and the use of ICT (primarily deferasirox) to improve outcomes in patients with MDS...
June 14, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29901292/-subcapsular-renal-hematomas-after-ureteroscopic-lithotripsy
#10
B G Guliev, B K Komyakov, A Yu Zaikin
INTRODUCTION: Renal hematomas (RH) are a rare complication of retrograde endoscopic lithotripsy (REL). This study aimed to investigate the incidence and causes of RH after REL in patients with ureteral stones of different locations. MATERIALS AND METHODS: From 2001 to 2016, 1214 REL were performed at the Urology Clinic of the Mechnikov NWSMU. The analyzes of patients who had RH after REL included the following parameters: age, gender, history of upper urinary tract (UUT) surgery and concomitant diseases (diabetes mellitus, hypertension), the baseline kidney function, the stone characteristics and the degree of hydronephrosis observed in the postoperative period, results of laboratory tests, ultrasound and spiral computed tomography (SCT) of the kidneys...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900001/transfusion-management-of-incident-dialysis-patients-in-canada-a-prospective-observational-study
#11
Aminu K Bello, Christine M Ribic, Serge H Cournoyer, Mercedeh Kiaii, Martine LeBlanc, Melanie Poulin-Costello, David N Churchill, Norman Muirhead
Background: Several studies have demonstrated harm associated with using erythropoiesis-stimulating agents (ESA) to achieve higher hemoglobin (Hb) levels. Subsequently, more conservative use of ESAs has changed anemia therapy in patients with chronic renal failure. Objective: The objectives were to identify transfusion rates in hemodialysis (HD) patients during the first year of therapy, to identify factors associated with the probability of transfusion, describe reasons for the transfusions, and identify the Hb values associated with each transfusion...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29898960/antibody-inhibition-of-properdin-prevents-complement-mediated-intravascular-and-extravascular-hemolysis
#12
Damodar Gullipalli, Fengkui Zhang, Sayaka Sato, Yoshiyasu Ueda, Yuko Kimura, Madhu Golla, Takashi Miwa, Jianxiang Wang, Wen-Chao Song
Paroxysmal nocturnal hemoglobinuria (PNH) is a serious blood disorder characterized by dysregulated complement activation on blood cells. Eculizumab, the current standard therapy and a humanized anti-C5 mAb, relieves anemia and thrombosis symptoms of PNH patients by preventing complement-dependent intravascular hemolysis (IVH). However, up to 20% of PNH patients on long-term eculizumab treatment still suffer from significant anemia and are transfusion dependent because of extravascular hemolysis (EVH) of C3-opsonized PNH erythrocytes...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29895275/-late-for-testing-early-for-antiretroviral-therapy-less-likely-to-die-results-from-a-large-hiv-cohort-study-in-china-2006-2014
#13
Houlin Tang, Yurong Mao, Weiming Tang, Jing Han, Juan Xu, Jian Li
BACKGROUND: Timely HIV testing and initiation of antiretroviral therapy are two major determinants of survival for HIV-infected individuals. Our study aimed to explore the trend of late HIV/AIDS diagnoses and to assess the factors associated with these late diagnoses in China between 2006 and 2014. METHODS: We used data from the Chinese Comprehensive Response Information Management System of HIV/AIDS (CRIMS). All individuals who tested positive for HIV between 2006 and 2014 in China and were at least 15 years of age were included...
June 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29893484/clinical-utility-of-endocrine-markers-predicting-myocardial-siderosis-in-transfusion-dependent-thalassemia-major
#14
Lubaina Ehsan, Mariam Rashid, Najveen Alvi, Khadija Awais, Omair Nadeem, Aleezay Asghar, Fatimah Sajjad, Malika Fatima, Asim Qidwai, Shabneez Hussain, Erum Hasan, Nick Brown, Sadaf Altaf, Babar Hasan, Salman Kirmani
BACKGROUND: Endocrinopathy due to iron overload is the most common morbidity whereas myocardial siderosis causing toxic cardiomyopathy is the leading cause of mortality among patients with transfusion dependent thalassemia major (TDTM). If detected early, this can be treated with aggressive chelation. T2* cardiac magnetic resonance imaging (CMR) guided chelation protocols are now the gold standard but have limited availability in low and middle-income countries. We hypothesized that markers of endocrine dysfunction would correlate with T2* CMR and can be used to predict the severity of myocardial siderosis and guide chelation therapy...
June 12, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29891188/development-of-a-postoperative-care-pathway-for-children-with-renal-tumors
#15
A F Saltzman, J C Warncke, A N Colvin, A Carrasco, J P Roach, J L Bruny, N G Cost
PURPOSE: To identify the factors associated with a shorter postoperative stay, as an initial step to develop a care pathway for children undergoing extirpative kidney surgery. STUDY DESIGN: This study retrospectively reviewed patients managed with upfront open radical nephrectomy for renal tumors between 2005 and 2016 at a pediatric tertiary care facility. Univariate and multivariate logistic regression were performed to identify factors associated with early discharge (by postoperative day 4)...
May 31, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29890567/red-cell-transfusion-and-clinical-outcomes-in-acute-pulmonary-embolism-harmful-therapy-or-an-indicator-of-sicker-patients-with-poor-prognosis
#16
EDITORIAL
Sanjeev D Chunilal, Erica M Wood
No abstract text is available yet for this article.
June 11, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29889031/i-131-radiation-induced-myelosuppression-in-differentiated-thyroid-cancer-therapy
#17
Stephan Probst, Gad Abikhzer, Guillaume Chaussé, Michael Tamilia
Radioactive iodine (RAI) treatment of differentiated thyroid cancer has been used in clinical practice for almost 60 years and is generally accepted to be a safe and efficacious treatment. Severe toxicity in the form of radiation pneumonitis, sometimes progressing to fibrosis, and bone marrow suppression are reported but remain rare. We present a case of severe myelosuppression requiring hospitalization and transfusion support in an otherwise well, young female patient who had received 175 mCi I-131 for low-volume micronodular lung disease one month prior, with a cumulative lifetime administered activity of 575 mCi...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29888721/a-3-year-study-of-deferasirox-therapy-in-sickle-cell-disease-patients-in-basra-southern-iraq
#18
A M Mohsin, M K Hassan
Background: Patients with sickle cell disease (SCD) may require repeated transfusions, which inevitably lead to iron overload (IOL). Aims: : This study aims to assess the effectiveness and safety of oral deferasirox (DFX) in patients with SCD and transfusional IOL. Patients and Methods: A descriptive study has been performed on patients with SCD who have completed at least 3 years on DFX. Height and weight were checked every 3-6 months. The efficacy was assessed based on serum ferritin (SF) levels...
June 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29887185/pediatric-transfusion-global-perspectives-on-some-clinical-and-methodological-aspects-of-cellular-therapy-apheresis-emergencies-and-blood-transfusion-in-pediatric-patients
#19
EDITORIAL
Jerard Segatchian, Irena Sniecinski
No abstract text is available yet for this article.
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29884513/acquired-antibodies-to-%C3%AE-iib%C3%AE-3-in-glanzmann-thrombasthenia-from-transfusion-and-pregnancy-to-bone-marrow-transplants-and-beyond
#20
REVIEW
Alan T Nurden
Patients with the inherited bleeding disorder Glanzmann thrombasthenia (GT) possess platelets that lack αIIbβ3 integrin and fail to aggregate, and have moderate to severe mucocutaneous bleeding. Many become refractory to platelet transfusions due to the formation of isoantibodies to αIIbβ3 with the rapid elimination of donor platelets and/or a block of function. Epitope characterization has shown isoantibodies to be polyclonal and to recognize different epitopes on the integrin with β3 a major site and αvβ3 on endothelial and vascular cells a newly recognized target...
May 23, 2018: Transfusion Medicine Reviews
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