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https://www.readbyqxmd.com/read/28435080/investigating-mechanisms-of-tendon-damage-by-measuring-multi-scale-recovery-following-tensile-loading
#1
Andrea H Lee, Spencer E Szczesny, Michael H Santare, Dawn M Elliott
Tendon pathology is associated with damage. While tendon damage is likely initiated by mechanical loading, little is known about the specific etiology. Damage is defined as an irreversible change in the microstructure that alters the macroscopic mechanical parameters. In tendon, the link between mechanical loading and microstructural damage, resulting in macroscopic changes, is not fully elucidated. In addition, tendon damage at the macroscale has been proposed to initiate when tendon is loaded beyond a strain threshold, yet the metrics to define the damage threshold are not determined...
April 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28434685/influence-of-inhomogeneous-dental-posts-on-stress-distribution-in-tooth-root-and-interfaces-three-dimensional-finite-element-analysis
#2
Mojtaba Mahmoudi, Ali Reza Saidi, Parviz Amini, Maryam Alsadat Hashemipour
STATEMENT OF PROBLEM: In post-core crown restorations, the use of flexible posts concentrates stresses at the dentin and the use of stiff posts concentrates stresses at the interfaces. A class of inhomogeneous materials (called functionally graded materials) has been proposed for posts to resolve the weaknesses of both flexible and rigid posts. PURPOSE: The purpose of this in vitro study was to design an inhomogeneous post and investigate its influence on the stress distribution of post-core crown restorations...
April 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28433886/controlled-release-of-metformin-from-chitosan-based-nanocomposite-films-containing-mesoporous-mcm-41-nanoparticles-as-novel-drug-delivery-systems
#3
Zahra Shariatinia, Zahra Zahraee
Biocompatible nanocomposite films based on blended chitosan and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (BP) polymers containing metformin (MET) drug and MCM-41 or MCM-41-APS (APS=aminopropylsilane) nanoparticles (NPs) were designed and fabricated in order to prepare novel drug delivery systems which are useful for controlled drug release purposes. The total pore volume and mesopore volume of MCM-41 were measured equal to 1.08 and 1.05 cm(3)/g but those of MCM-41-APS were 0...
April 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28428541/tissue-engineered-cornea-constructed-with-compressed-collagen-and-laser-perforated-electrospun-mat
#4
Bin Kong, Wei Sun, Guoshi Chen, Song Tang, Ming Li, Zengwu Shao, Shengli Mi
While Plastic Compressed (PC) collagen technique is often used to fabricate bioengineered constructs, PC collagen gels are too weak to be sutured or conveniently handled for clinical applications. To overcome this limitation, electrospun poly (lactic-co-glycolide) (PLGA) mats, which have excellent biocompatibility and mechanical properties, were combined with PC collagen to fabricate sandwich-like hybrid constructs. By laser-perforating holes with different sizes and spacings in the electrospun mats to regulate the mechanical properties and light transmittance of the hybrid constructs, we produced hybrid constructs with properties very suitable to apply in corneal tissue engineering...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28426059/evolution-of-dealloying-induced-strain-in-nanoporous-gold-crystals
#5
Yu-Chen Karen Chen-Wiegart, Ross Harder, David C Dunand, Ian McNulty
We studied the evolution of dealloying-induced strain along the {111} in a Ag-Au nano-crystal in situ, during formation of nanoporous gold at the initial stage of dealloying using Bragg coherent X-ray diffractive imaging. The strain magnitude with maximum probability in the crystal doubled in 10 s of dealloying. Although formation of nano-pores just began at the surface, the greatest strain is located 60-80 nm deep within the crystal. Dealloying induced a compressive strain in this region, indicating volume shrinkage occurred during pore formation...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28425561/creating-homogenous-strain-distribution-within-3d-cell-encapsulated-constructs-using-a-simple-and-cost-effective-uniaxial-tensile-bioreactor-design-and-validation-study
#6
Gayathri Subramanian, Mostafa Elsaadany, Callan Bialorucki, Eda Yildirim-Ayan
Mechanical loading bioreactors capable of applying uniaxial tensile strains are emerging to be a valuable tool to investigate physiologically-relevant cellular signaling pathways and biochemical expression. In this study, we have introduced a simple and cost-effective uniaxial tensile strain bioreactor for the application of precise and homogenous uniaxial strains to 3D cell-encapsulated collagen constructs at physiological loading strains (0-12%) and frequencies (0.01-1 Hz). The bioreactor employs silicone-based loading chambers specifically designed to stretch constructs without direct gripping to minimize stress concentration at the ends of the construct and preserve its integrity...
April 20, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28422241/super-tough-ultra-stretchable-and-strongly-compressive-hydrogels-with-core-shell-latex-particles-inducing-efficient-aggregation-of-hydrophobic-chains
#7
Xiuyan Ren, Chang Huang, Lijie Duan, Baijun Liu, Lvjun Bu, Shuang Guan, Jiliang Hou, Huixuan Zhang, Guanghui Gao
Toughness, strechability and compressibility for hydrogels were ordinarily balanced for their use as mechanically responsive materials. For example, macromolecular microsphere composite hydrogels with chemical crosslinking exhibited excellent compression strength and strechability, but poor tensile stress. Here, a novel strategy for the preparation of a super-tough, ultra-stretchable and strongly compressive hydrogel was proposed by introducing core-shell latex particles (LPs) as crosslinking centers for inducing efficient aggregation of hydrophobic chains...
April 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28415471/synthesis-and-characterization-of-ti-27-5nb-alloy-made-by-clad%C3%A2-additive-manufacturing-process-for-biomedical-applications
#8
M Fischer, P Laheurte, P Acquier, D Joguet, L Peltier, T Petithory, K Anselme, P Mille
Biocompatible beta-titanium alloys such as Ti-27.5(at.%)Nb are good candidates for implantology and arthroplasty applications as their particular mechanical properties, including low Young's modulus, could significantly reduce the stress-shielding phenomenon usually occurring after surgery. The CLAD® process is a powder blown additive manufacturing process that allows the manufacture of patient specific (i.e. custom) implants. Thus, the use of Ti-27.5(at.%)Nb alloy formed by CLAD® process for biomedical applications as a mean to increase cytocompatibility and mechanical biocompatibility was investigated in this study...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415419/lsp-mao-composite-bio-coating-on-az80-magnesium-alloy-for-biomedical-application
#9
Ying Xiong, Qiang Hu, Renguo Song, Xiaxia Hu
A composite bio-coating was fabricated on AZ80 magnesium (Mg) alloy by using micro-arc oxidation (MAO) under the pretreatment of laser shock peening (LSP) in order to improve the bio-corrosion resistance and the mechanical integrity. LSP treatment could induce grain refinement and compressive residual stress field on the surface of material. MAO bio-coating was grown in alkaline electrolyte with hydroxyapatite (HA, Ca10(PO4)6(OH)2) to improve the biological properties of the material. The microstructure, element and phase composition for untreated based material (BM) and treated samples (LSP layer, MAO bio-coating and LSP/MAO composite bio-coating) were investigated by transmission electron microscopy (TEM), scanning electron microscope (SEM), energy dispersion spectroscopy (EDS) and X-ray diffraction (XRD)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415416/in-vitro-and-in-vivo-corrosion-mechanical-properties-and-biocompatibility-evaluation-of-mgf2-coated-mg-zn-zr-alloy-as-cancellous-screws
#10
Zhen Li, Sun Shizhao, Minfang Chen, Bradley Dean Fahlman, Debao Liu, Hongwei Bi
Magnesium (Mg) and its alloys as biodegradable materials have received much attention in the orthopedics applications; however, the corrosion behavior of these metals in vivo remains challenging. In this work, a dense and nanoscale magnesium fluoride (MgF2) coating was deposited on the surface of Mg-Zn-Zr (MZZ) alloy cancellous screw. The MZZ cancellous screw with MgF2 coating maintained an integrated shape and high yield tensile stress after 30days immersion in SBF, comparing with the bare screw. Hydrogen releasing rate of the MZZ samples was suppressed at a lower level at the initial stage, which is in favour of the adhesion of the cells...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414457/electrochemically-induced-shape-memory-behavior-of-si-nanopillar-patterned-electrode-for-li-ion-batteries
#11
ByungDae Son, IlWon Seong, Jun Kyu Lee, Ju-Hyeon Shin, Heon Lee, Woo Young Yoon
A nanopillar-patterned Si substrate was fabricated by photolithography, and its potential as an anode material for Li ion secondary batteries was investigated. The Si nanopillar electrode showed a capacity of approximately 3000 mAh g-1 during 100 charging/discharging cycles, with 98.3% capacity retention. And it was revealed that the nanopillars underwent delithiation via a process similar to shape-memory behavior. Despite the tensile stress and structural fractures resulting from repeated lithiation, the nanoscale size and residual crystalline tip of the pillar (influenced by the bulk crystalline Si base) enabled recrystallization and transformation into a single crystalline phase...
April 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28413834/synthesis-and-characterization-of-zinc-oxide-thin-films-for-optoelectronic-applications
#12
E Muchuweni, T S Sathiaraj, H Nyakotyo
Micro-ring structured zinc oxide (ZnO) thin films were prepared on glass substrates by spray pyrolysis and their structural, morphological, optical and electrical properties were investigated. X-ray Diffraction (XRD) analysis revealed the films' hexagonal wurtzite phase with a preferred (002) grain orientation. The mean crystallite size calculated on the basis of the Debye-Scherrer model was 24 nm and a small dislocation density of [Formula: see text] was obtained, indicating the existence of few lattice defects and good crystallinity...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28408061/predicting-tissue-susceptibility-to-mechanical-cavitation-damage-in-therapeutic-ultrasound
#13
Lauren Mancia, Eli Vlaisavljevich, Zhen Xu, Eric Johnsen
Histotripsy is a developing focused ultrasound procedure that uses cavitation bubbles to mechanically homogenize soft tissue. To better understand the mechanics of tissue damage, a numerical model of single-bubble dynamics was used to calculate stress, strain and strain rate fields produced by a cavitation bubble exposed to a tensile histotripsy pulse. The explosive bubble growth and its subsequent collapse were found to depend on the properties of the surrounding material and on the histotripsy pulse. Stresses far greater than gigapascals were observed close to the bubble wall, but attenuated by four to six orders of magnitude within 50 μm from the bubble wall, with at least two orders of magnitude attenuation occurring within the first 10 μm from the bubble...
April 10, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28406163/actomyosin-contractility-provokes-contact-inhibition-in-e-cadherin-ligated-keratinocytes
#14
Hiroaki Hirata, Mikhail Samsonov, Masahiro Sokabe
Confluence-dependent inhibition of epithelial cell proliferation, termed contact inhibition, is crucial for epithelial homeostasis and organ size control. Here we report that among epithelial cells, keratinocytes, which compose the stratified epithelium in the skin, possess a unique, actomyosin-dependent mechanism for contact inhibition. We have observed that under actomyosin-inhibited conditions, cell-cell contact itself through E-cadherin promotes proliferation of keratinocytes. Actomyosin activity in confluent keratinocytes, however, inhibits nuclear localization of β-catenin and YAP, and causes attenuation of β-catenin- and YAP-driven cell proliferation...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28403248/effect-of-buccal-implant-inclination-on-stresses-around-two-implant-retained-overdentures-with-resilient-stud-attachments
#15
Moustafa Abdou Elsyad, Karima Salah Abid, Elsayed Abd Elkhalek
PURPOSE: This study aimed to evaluate the effect of buccal implant inclination on stresses around two-implant-retained overdentures with resilient stud attachments. MATERIALS AND METHODS: Four acrylic models representing a mandibular edentulous ridge were constructed. For each model, two implants were placed at canine areas. Models were classified into four types according to the degree of buccal implant inclination: Group I (GI, 0 degrees), Group II (GII, 10 degrees), Group III (GIII, 20 degrees), and Group IV (GIV, 30 degrees)...
April 12, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28397451/the-stress-relaxation-process-in-sutures-tied-with-a-surgeon-s-knot-in-a-simulated-biological-environment
#16
Aneta Liber-Kneć, Sylwia Łagan
BACKGROUND: The exact characteristics of sutures are not only the basis for selecting from among different types of suture, but also provide the necessary information for the design of new surgical sutures. Apart from information relating to the breaking load of a suture reported in pharmacopoeias, the viscoelastic properties of sutures can be an additional selection criterium - one that influences stitching quality, especially when there is a risk of wound dehiscence. OBJECTIVES: The aim of the study was to assess the stress relaxation process for 3 polymeric sutures in an environment simulating the conditions in a living organism and (for comparison) in room conditions...
July 2016: Polimery W Medycynie
https://www.readbyqxmd.com/read/28387996/porosity-and-tissue-integration-of-elastic-mesh-implants-evaluated-in-vitro-and-in-vivo
#17
Alexander Ciritsis, Andreas Horbach, Manfred Staat, Christiane K Kuhl, Nils Andreas Kraemer
PURPOSE: In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. MATERIAL AND METHODS: Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro...
April 7, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28387230/high-temperature-deformation-mechanism-in-hierarchical-and-single-precipitate-strengthened-ferritic-alloys-by-in-situ-neutron-diffraction-studies
#18
Gian Song, Zhiqian Sun, Lin Li, Bjørn Clausen, Shu Yan Zhang, Yanfei Gao, Peter K Liaw
The ferritic Fe-Cr-Ni-Al-Ti alloys strengthened by hierarchical-Ni2TiAl/NiAl or single-Ni2TiAl precipitates have been developed and received great attentions due to their superior creep resistance, as compared to conventional ferritic steels. Although the significant improvement of the creep resistance is achieved in the hierarchical-precipitate-strengthened ferritic alloy, the in-depth understanding of its high-temperature deformation mechanisms is essential to further optimize the microstructure and mechanical properties, and advance the development of the creep resistant materials...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386444/fabrication-and-characterization-of-electrospun-poly-e-caprolactone-fibrous-membrane-with-antibacterial-functionality
#19
Idris Cerkez, Ayse Sezer, Sukhwinder K Bhullar
This research study is mainly targeted on fabrication and characterization of antibacterial poly(e-caprolactone) (PCL) based fibrous membrane containing silver chloride particles. Micro/nano fibres were produced by electrospinning and characterized with TGA, DSC, SEM and mechanical analysis. It was found that addition of silver particles slightly reduced onset of thermal degradation and increased crystallization temperature of neat PCL. Silver-loaded samples exhibited higher tensile stress and lower strain revealing that the particles behaved as reinforcing agent...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28386269/silicon-and-plants-current-knowledge-and-technological-perspectives
#20
Marie Luyckx, Jean-Francois Hausman, Stanley Lutts, Gea Guerriero
Elemental silicon (Si), after oxygen, is the second most abundant element in the earth's crust, which is mainly composed of silicates. Si is not considered essential for plant growth and development, however, increasing evidence in the literature shows that this metalloid is beneficial to plants, especially under stress conditions. Indeed Si alleviates the toxic effects caused by abiotic stresses, e.g., salt stress, drought, heavy metals, to name a few. Biogenic silica is also a deterrent against herbivores...
2017: Frontiers in Plant Science
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