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https://www.readbyqxmd.com/read/29320554/a-census-of-p-longum-s-phytochemicals-and-their-network-pharmacological-evaluation-for-identifying-novel-drug-like-molecules-against-various-diseases-with-a-special-focus-on-neurological-disorders
#1
Neha Choudhary, Vikram Singh
Piper longum (P. longum, also called as long pepper) is one of the common culinary herbs that has been extensively used as a crucial constituent in various indigenous medicines, specifically in traditional Indian medicinal system known as Ayurveda. For exploring the comprehensive effect of its constituents in humans at proteomic and metabolic levels, we have reviewed all of its known phytochemicals and enquired about their regulatory potential against various protein targets by developing high-confidence tripartite networks consisting of phytochemical-protein target-disease association...
2018: PloS One
https://www.readbyqxmd.com/read/29302196/when-good-times-go-bad-managing-legal-high-complications-in-the-emergency-department
#2
REVIEW
Charles R Caffrey, Patrick M Lank
Patients can use numerous drugs that exist outside of existing regulatory statutes in order to get "legal highs." Legal psychoactive substances represent a challenge to the emergency medicine physician due to the sheer number of available agents, their multiple toxidromes and presentations, their escaping traditional methods of analysis, and the reluctance of patients to divulge their use of these agents. This paper endeavors to cover a wide variety of "legal highs," or uncontrolled psychoactive substances that may have abuse potential and may result in serious toxicity...
2018: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/29281705/anti-inflammatory-effect-of-allium-hookeri-on-carrageenan-induced-air-pouch-mouse-model
#3
Jung-Eun Kim, Kyung-Mok Park, Soon-Young Lee, Ji-Hye Seo, In-Soo Yoon, Chun-Sik Bae, Jin-Cheol Yoo, Mi-Ae Bang, Seung-Sik Cho, Dae-Hun Park
Inflammation is a commonly observed immune reaction, and rheumatoid arthritis is a particularly severe inflammatory disease. In this study, we used an air pouch mouse model to evaluate the anti-inflammatory potential of Allium hookeri, which has both been used as a culinary material and a traditional medicine in south-eastern Asia for many years. Allium hookeri suppressed typical symptoms of inflammation, such as condensation of the air pouch membrane, and inhibited the expression of several inducible proinflammatory cytokines such as IL-1β, IL-6, IL-13, and TNF-α...
2017: PloS One
https://www.readbyqxmd.com/read/29237384/ros-scavenging-and-anti-tyrosinase-properties-of-crocetin-on-b16f10-murine-melanoma-cells
#4
Seyed Hamed Hashemi-Shahri, Alireza Golshan, Seyed Ahmad Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar, Zahra Tayarani-Najaran
BACKGROUND: Crocus sativus (Iridaceae) has been traditionally used in the Iranian folk medicine and as a culinary additive. Major components of the plant that are responsible for biological properties are saffranal, crocin, picrocrocin and crocetin. Although the level of crocetin is not high, some of the important activities of saffron such as antioxidant activity have been attributed to crocetin. OBJECTIVE: In the present study, we investigated the effects of crocetin on melanogenesis in B16 melanoma cells...
December 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29199585/optimization-of-submerged-cultivation-conditions-for-production-of-big-cup-culinary-medicinal-mushroom-clitocybe-maxima-agaricomycetes-biomass-with-significant-antioxidative-and-antihyperlipidemic-activities
#5
Shu-Hui Hu, Ker-Shew Chen, Ming-Yi Liu, Peter Chi Keung Cheung, Jinn-Chyi Wang, Sue-Joan Chang
In this study, a large Clitocybe maxima mycelium biomass was obtained by submerged cultivation under optimal conditions. Three test samples from lyophilized mycelia, including hot water extract (CW) and elutes from solvents with different polarity (CA and CB), were combined and used to explore antioxidant and antihyper-lipidemic activities in vitro and in vivo. The CA group showed the highest DPPH free radical scavenging activity and iron-reducing capability at concentrations of 6.0% and 3.0% (w/v), respectively...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199574/immunoreactivity-of-the-cold-water-extract-of-royal-sun-culinary-medicinal-mushroom-agaricus-brasiliensis-strain-ka21-agaricomycetes-assessed-by-immunoglobulin-preparations-for-intravenous-injection
#6
Katsuya Tajima, Masuro Motoi, Akitomo Motoi, Daisuke Yamanaka, Ken-Ichi Ishibashi, Yoshiyuki Adachi, Naohito Ohno
The royal sun medicinal mushroom, Agaricus brasiliensis, is a health food material that helps to improve quality of life. A. brasiliensis has long been used as a tea by extraction with cold and hot water. Our group has been investigating the immunopharmacological activities of the A. brasiliensis KA21 strain, which is cultivated outdoors. We prepared cold water (AgCWE) and hot water (AgHWE) extracts of this strain. AgCWE contained a larger proportion of proteins, including enzymes, and showed a brownish color during the extraction process...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199571/genotoxicity-and-single-treatment-toxicity-evaluation-of-mycoleptodonoides-aitchisonii-agaricomycetes-water-extract
#7
Soon-Young Lee, Dae-Hun Park, Ji-Young Kim, Young-Ju Lee, Deuk-Sil Oh, Mi-Ae Bang, Joung-Wook Seo
Mushrooms have long been used worldwide for culinary and medicinal purposes because of their various nutrients and active constituents. The safety of mushrooms as a culinary ingredient requires validation. Although Mycoleptodonoides aitchisonii has long been used for culinary purposes in East Asia, it has not been authorized by a regulatory agency. In this study we conducted genotoxicity and single-treatment toxicity tests according to the guidelines of the Organisation for Economic Co-operation and Development...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199563/structural-characteristics-of-the-novel-polysaccharide-fvpa1-from-winter-culinary-medicinal-mushroom-flammulina-velutipes-agaricomycetes-capable-of-enhancing-natural-killer-cell-activity-against-k562-tumor-cells
#8
Wei Jia, Jie Feng, Jing-Song Zhang, Chi-Chung Lin, Wen-Han Wang, Hong-Ge Chen
FVPA1, a novel polysaccharide, has been isolated from fruiting bodies of the culinary-medicinal mushroom Flammulina velutipes, a historically popular, widely cultivated and consumed functional food with an attractive taste, beneficial nutraceutical properties such as antitumor and immunomodulatory effects, and a number of essential biological activities. The average molecular weight was estimated to be ~1.8 × 104 Da based on high-performance size exclusion chromatography. Sugar analyses, methylation analyses, and 1H, 13C, and 2-dimensional nuclear magnetic resonance spectroscopy revealed the following structure of the repeating units of the FVPA1 polysaccharide Identification of this structure would conceivably lead to better understanding of the nutraceutical functions of this very important edible fungus...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199552/in-vitro-and-in-vivo-antitumoral-activity-of-exobiopolymers-from-the-royal-sun-culinary-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes
#9
Vanessa Sovrani, Juliana da Rosa, Mariana de Paula Drewinski, Franciely Grose Colodi, Tânia Toyomi Tominaga, Herta Stutz Dalla Santa, Rosilene Rebeca
We studied antitumor activity in vitro and in vivo and partial chemical characterization of exobiopolymers (EBPs) of Agaricus brasiliensis produced by submerged cultivation. The EBPs comprised 61.2% total sugar and 22.3% total protein, and the chromatographic profile mainly identified mannose (65.5%), galactose (17.5%), and glucose (13.1%). In vitro analysis revealed a dose with antitumor effectiveness, time-dependent treatment, and 46% inhibition of solid Walker 256 tumors in rats. Metabolic changes were significant in the spleens of the animals; this is possibly related to higher immune activity triggered by the presence of EBPs in the treated group...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199551/royal-sun-culinary-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes-supplement-in-training-capacity-improvement-parameters
#10
Flávio F Silva, Guilherme A C de Oliveira, Hugo C Martins Costa, Wiliam C B Regis
People seek a greater quality of life and healthy aging that culminates in improved self-esteem and vitality in the performance of daily activities; this is generating a growing number of people enrolled in gyms in search of quick results. However, this training can result in physical and metabolic damage. During physical exercise, under conditions of oxidative stress, changes take place that lead to the onset of fatigue. The Agaricus brasiliensis mushroom is native to Brazil and has therapeutic potential, with widely studied antioxidant and immunomodulatory capabilities...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29142398/cytotoxic-antimitotic-and-antiproliferation-studies-on-rasam-a-south-indian-traditional-functional-food
#11
Agilandeswari Devarajan, M K Mohan Maruga Raja
Background: Rasam is a traditional South Indian food, prepared using tamarind juice as a base, with a variety of spices. Rasam, with all its ingredients medicinally claimed for various ailments, is a functional food. Systematic consumption of traditional functional food provides an excellent preventive measure to ward off many diseases. Objective: To study rasam for cytotoxic, antimitotic, and antiproliferation potential beyond its culinary and nutritional effect...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29125648/pharmacological-effects-of-zataria-multiflora-boiss-l-and-its-constituents-focus-on-their-anti-inflammatory-antioxidant-and-immunomodulatory-effects
#12
REVIEW
Mohammad Reza Khazdair, Vahideh Ghorani, Azam Alavinezhad, Mohammad Hossein Boskabady
Zataria multiflora Boiss (Z. multiflora) belongs to the Lamiaceae family, is used traditionally for culinary and medicinal purposes. Different pharmacological effects have been described for the plant including; bronchodilation, vasodilation and effect on lung inflammation. The plant is also used as a remedy against cough in the traditional medicine. In this article, "pharmacological effects of Z. multiflora and its constituents focusing on their anti-inflammatory, antioxidant and immunomodulatory properties were reviewed" by searching various databases until "June" 2016...
November 10, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29118777/capparis-spinosa-l-in-a-systematic-review-a-xerophilous-species-of-multi-values-and-promising-potentialities-for-agrosystems-under-the-threat-of-global-warming
#13
REVIEW
Stephanie Chedraoui, Alain Abi-Rizk, Marc El-Beyrouthy, Lamis Chalak, Naim Ouaini, Loïc Rajjou
Caper (Capparis spinosa L.) is a xerophytic shrub with a remarkable adaptability to harsh environments. This plant species is of great interest for its medicinal/pharmacological properties and its culinary uses. Its phytochemical importance relies on many bioactive components present in different organs and its cultivation can be of considerable economic value. Moreover, taxonomic identification of C. spinosa L. has been difficult due to its wide heterogeneity, and many authors fell into confusion due to the scarcity of genetic studies...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29084156/the-dietary-furocoumarin-imperatorin-increases-plasma-glp-1-levels-in-type-1-like-diabetic-rats
#14
Lin-Yu Wang, Kai-Chun Cheng, Yingxiao Li, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Imperatorin, a dietary furocoumarin, is found not only in medicinal plants, but also in popular culinary herbs, such as parsley and fennel. Recently, imperatorin has been shown to activate GPR119 in cells. Another GPR, GPR131, also called TGR5 or G-protein-coupled bile acid receptor 1 (GPBAR1), is known to regulate glucose metabolism. Additionally, TGR5 activation increases glucagon-like peptide (GLP-1) secretion to lower blood sugar levels in animals. Therefore, the present study aims to determine whether the effects of imperatorin on GLP-1 secretion are mediated by TGR5...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29071175/phytochemical-profile-aldose-reductase-inhibitory-and-antioxidant-activities-of-indian-traditional-medicinal-coccinia-grandis-l-fruit-extract
#15
Dasharath Kondhare, Harshad Lade
Coccinia grandis (L.) fruits (CGFs) are commonly used for culinary purposes and has several therapeutic applications in the Southeast Asia. The aim of this work was to evaluate phytochemical profile, aldose reductase inhibitory (ARI), and antioxidant activities of CGF extract. The CGFs were extracted with different solvents including petroleum ether, dichloromethane, acetone, methanol, and water. The highest yield of total extractable compounds (34.82%) and phenolic content (11.7 ± 0.43 mg of GAE/g dried extract) was found in methanol extract, whereas water extract showed the maximum content of total flavonoids (82...
December 2017: 3 Biotech
https://www.readbyqxmd.com/read/29065496/curcumin-a-review-of-its-effects-on-human-health
#16
REVIEW
Susan J Hewlings, Douglas S Kalman
Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions...
October 22, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29058421/authentication-of-zanthoxylum-species-based-on-integrated-analysis-of-complete-chloroplast-genome-sequences-and-metabolite-profiles
#17
Hyeon Ju Lee, Hyun Jo Koo, Jonghoon Lee, Dong Young Lee, Vo Ngoc Linh Giang, Minjung Kim, Hyeonah Shim, Jee Young Park, Ki-Oug Yoo, Sang Hyun Sung, Tae-Jin Yang
We performed chloroplast genome sequencing and comparative analysis of two Rutaceae species, Zanthoxylum schinifolium (Korean pepper tree) and Z. piperitum (Japanese pepper tree), which are medicinal and culinary crops in Asia. We identified more than 837 single nucleotide polymorphisms and 103 insertions/deletions (InDels) based on a comparison of the two chloroplast genomes and developed seven DNA markers derived from five tandem repeats and two InDel variations that discriminated between Korean Zanthoxylum species...
October 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29043994/terpenic-profile-of-different-rosmarinus-officinalis-extracts
#18
Neli-Kinga Olah, Daniela Benedec, Sonia Socaci, Claudia Crina Toma, Lorena Filip, Claudiu Morgovan, Daniela Hanganu
The Rosemary (Rosmarinus officinalis L.), a well-known medicinal and culinary herb, was studied to compare the terpenic profile of different extracts obtained from dry and fresh herb. There were studied the volatile oil extracted by hydro distillation from dry plant, the hydroalcoholic extracts obtained from fresh respectively dry plant and the glycerol macerate obtained from fresh plant, by GC-MS using headspace injection. The separated compounds were identified using a MS spectra library. The quantitative determination was performed by normalization respectively by calibration curve method for 1,8-cineole, alpha-pinene and D-limonene...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29034472/protective-effects-of-curcumin-against-aflatoxicosis-a-comprehensive-review
#19
REVIEW
Mohammad Mohajeri, Behzad Behnam, Arrigo F G Cicero, Amirhossein Sahebkar
Aflatoxicosis is a deleterious medical condition that results from aflatoxins (AFs) or ochratoxins (OTs). Contamination with these toxins exerts detrimental effects on the liver, kidneys, reproductive organs, and also on immunological and cardiovascular systems. Aflatoxicosis is closely associated with overproduction of reactive oxygen species (ROS) as key contributors to oxidative and nitrosative stress responses, and subsequent damages to lipids, proteins, RNA, and DNA. The main target organ for AF toxicity is the liver, where DNA adducts, degranulation of endoplasmic reticulum, increased hepatic lipid peroxide, GSH depletion, mitochondrial dysfunction, and reduction of enzymatic and non-enzymatic antioxidants are manifestations of aflatoxicosis...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29034240/dark-chocolate-opportunity-for-an-alliance-between-medical-science-and-the-food-industry
#20
Ivan M Petyaev, Yuriy K Bashmakov
Dark chocolate (DC) was originally introduced in human nutrition as a medicinal product consumable in a liquid form. Century-long efforts of food industry transformed this hardly appealing product into a valuable modern culinary delight with clear predominance of confectionery brands of DC on the market. However, current epidemiological data as well as multiple experimental and clinical observations reveal that DC consumption may have a profound effect on cardiovascular, central nervous systems, hemostasis, and lipid metabolism...
2017: Frontiers in Nutrition
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