keyword
MENU ▼
Read by QxMD icon Read
search

Eicosapentaenoic acid

keyword
https://www.readbyqxmd.com/read/29926268/investigation-into-the-plasma-concentration-of-%C3%AF-3-polyunsaturated-fatty-acids-in-japanese-attention-deficit-hyperactivity-disorder-patients
#1
Ken Yonezawa, Shunsuke Nonaka, Yuka Iwakura, Yuka Kusano, Yuko Funamoto, Nobukazu Kanchi, Naohiro Yamaguchi, Yuko Kusumoto, Akira Imamura, Hiroki Ozawa
Several studies report that patients with attention-deficit hyperactivity disorder (ADHD) have a low plasma concentration of polyunsaturated fatty acids (PUFAs). Since fish intake varies among countries and is high in Japan, those results may not apply to Japanese patients with ADHD. However, there is currently not enough evidence to support this. We compared the plasma PUFAs levels of patients with ADHD with the standard reference levels for healthy subjects, and examined the relationship between those PUFAs levels and the subject's psychological evaluation...
June 20, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29925999/high-baseline-lipoprotein-a-level-as-a-risk-factor-for-coronary-artery-calcification-progression-sub-analysis-of-a-prospective-multicenter-trial
#2
Jun Ida, Kazuhiko Kotani, Toru Miyoshi, Kazufumi Nakamura, Kunihisa Kohno, Hirohiko Asonuma, Satoru Sakuragi, Masayuki Doi, Takashi Miki, Yasushi Koyama, Hiroshi Ito
Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins...
June 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29917092/systematic-review-and-meta-analysis-of-controlled-intervention-studies-on-the-effectiveness-of-long-chain-omega-3-fatty-acids-in-patients-with-nonalcoholic-fatty-liver-disease
#3
Kathy Musa-Veloso, Carolina Venditti, Han Youl Lee, Maryse Darch, Seth Floyd, Spencer West, Ryan Simon
Context: Treatment options for nonalcoholic fatty liver disease (NAFLD) are needed. Objective: The aim of this review was to systematically assess the effects of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid, on liver-related and metabolic outcomes in adult and pediatric patients with NAFLD. Data Sources: The online information service ProQuest Dialog was used to search 8 literature databases...
June 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29913556/immunoregulatory-role-of-15-lipoxygenase-in-the-pathogenesis-of-bacterial-keratitis
#4
Thomas W Carion, Matthew Greenwood, Abdul Shukkur Ebrahim, Andrew Jerome, Susmit Suvas, Karsten Gronert, Elizabeth A Berger
Although autacoids primarily derived from the cyclooxygenase-2 and 5-lipoxygenase (LOX) pathways are essential mediators of inflammation, endogenous specialized proresolving mediators (SPMs) act as robust agonists of resolution. SPM biosynthesis is initiated by the conversion of arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid primarily via the 12/15-LOX pathway. Although 12/15-LOX activity is prominent in the cornea, the role of SPM pathway activation during infection remains largely unknown and is the focus of the current study...
April 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29911253/dha-selectively-protects-samp-8-associated-cognitive-deficits-through-inhibition-of-jnk
#5
S Vela, Neira Sainz, María J Moreno-Aliaga, M Solas, María J Ramirez
A potential role of marine n-3 polyunsaturated fatty acids (ω-3 PUFAs) has been suggested in memory, learning, and cognitive processes. Therefore, ω-3 PUFAs might be a promising treatment option, albeit controversial, for Alzheimer's disease (AD). Among the different mechanisms that have been proposed as responsible for the beneficial effects of ω-3 PUFAs, inhibition of JNK stands as a particularly interesting candidate. In the present work, it has been studied whether the administration of two different PUFAs (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) and a DHA-derived specialized pro-resolving lipid mediator (MaR1) is able to reverse cognitive deficits in the senescence-accelerated mouse prone 8 (SAMP8) mouse model of sporadic AD...
June 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29908038/the-effect-of-dietary-corn-oil-and-fish-oil-supplementation-in-dogs-with-naturally-occurring-gingivitis
#6
Ana L Lourenço, Henriette E Booij-Vrieling, Carmen B Vossebeld, António Neves, Carlos Viegas, Ronald J Corbee
The aim of this randomized, double-blinded, placebo-controlled study was to evaluate if downregulation of the inflammatory response due to ingestion of high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can slow down gingivitis development, and thus delay the progression of periodontal disease (PD) in dogs. To this aim, 44 client-owned adult dogs (>1 and <8 years old) with naturally occurring PD (stages 1 and 2) were submitted to a plaque, gingivitis and calculus scoring followed by a dental cleaning procedure and collection of blood samples...
June 16, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29907355/effect-of-changing-the-lipid-component-of-home-parenteral-nutrition-in-adults
#7
Sylwia Osowska, Marek Kunecki, Jacek Sobocki, Joanna Tokarczyk, Krystyna Majewska, Mohamed Omidi, Marek Radkowski, Helena L Fisk, Philip C Calder
BACKGROUND: The effect of different lipid emulsions (LEs) within the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear. This study investigated the effect of changing adult HPN patients from a soybean oil based LE (Intralipid) to either a fish oil containing LE (providing n-3 fatty acids) (SMOFLipid) or an olive oil based LE (ClinOleic). METHODS: Thirty two adults receiving long-term HPN with Intralipid as the LE were transferred to receive either SMOFLipid (n = 13) or ClinOleic (n = 19) for 60 days...
June 6, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29901108/blocking-the-nav1-5-channel-using-eicosapentaenoic-acid-reduces-migration-and-proliferation-of-ovarian-cancer-cells
#8
Junxiu Liu, Dawei Liu, Jasmine J Liu, Chang Zhao, Shuzhong Yao, Liang Hong
Activity of the voltage-gated Nav1.5 sodium channel has been reported to be involved in cell proliferation, cancer invasion and gene expression. In addition, eicosapentaenoic acid (EPA) has recently been suggested to inhibit ovarian cancer cell growth and suppress tumor metastasis. The present study aimed to explore the association between EPA, the Nav1.5 sodium channel and ovarian cancer cells. Using patch-clamp technique and RNA interference approaches, sodium currents were recorded in epithelial ovarian cancer cells, and it was confirmed that the Nav1...
June 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29892132/prediction-of-fatty-acid-composition-of-sunflower-seeds-by-near-infrared-reflectance-spectroscopy
#9
Murat Reis Akkaya
This study was performed in order to evaluate efficiency of near-infrared reflectance spectroscopy (NIRS) for the determination of fatty acid composition ratio of sunflower seeds and to compare performance of calibration methods. Calibration equations were developed using modified partial least squares (MPLS) and partial least squares (PLS) regression methods. Ninety-three sunflower seed varieties were from test field of East Mediterranean Agricultural Research Institute. In order to determine the reference fatty acid values needed to construct calibration in NIRS analysis, sunflower seed samples were analyzed by gas chromatography method...
June 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29891784/dietary-conjugated-linoleic-acid-enriched-cheeses-influence-the-levels-of-circulating-n-3-highly-unsaturated-fatty-acids-in-humans
#10
Elisabetta Murru, Gianfranca Carta, Lina Cordeddu, Maria Paola Melis, Erika Desogus, Hastimansooreh Ansar, Yves Chilliard, Anne Ferlay, Catherine Stanton, Mairéad Coakley, R Paul Ross, Giovanni Piredda, Margherita Addis, Maria Cristina Mele, Giorgio Cannelli, Sebastiano Banni, Claudia Manca
n-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance and the inflammatory response. We investigated changes to the n-3 HUFA score of healthy adults, induced by different types and amounts of conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for different periods of time, compared to dietary fish oil (FO) pills (500 mg, each containing 100 mg of eicosapentaenoic and docosahexaenoic acids&mdash;EPA+DHA) or &alpha;-linolenic acid (ALA)-rich linseed oil (4 g, containing 2 g of ALA)...
June 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29886499/the-impact-of-preoperative-enteral-nutrition-enriched-with-eicosapentaenoic-acid-on-postoperative-hypercytokinemia-after-pancreatoduodenectomy-the-results-of-a-double-blinded-randomized-controlled-trial
#11
Ryo Ashida, Yukiyasu Okamura, Kanako Wakabayashi-Nakao, Takashi Mizuno, Shuichi Aoki, Katsuhiko Uesaka
AIMS: To investigate whether preoperative enteral diets -enriched in eicosapentaenoic acid (EPA) supplements could reduce the incidence of hypercytokinemia after pancreatoduodenectomy (PD) in a double-blinded randomized -controlled trial. METHODS: Patients with resectable periampullary cancer were randomized into either the control group or the treatment group. Patients in the treatment group received oral supplementation (600 kcal/day) containing EPA for 7 days before surgery...
June 8, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29881388/eicosapentaenoic-acid-enhances-the-effects-of-mesenchymal-stromal-cell-therapy-in-experimental-allergic-asthma
#12
Soraia Carvalho Abreu, Miquéias Lopes-Pacheco, Adriana Lopes da Silva, Debora Gonçalves Xisto, Tainá Batista de Oliveira, Jamil Zola Kitoko, Lígia Lins de Castro, Natália Recardo Amorim, Vanessa Martins, Luisa H A Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Hugo Caire de Castro Faria-Neto, Priscilla Christina Olsen, Daniel Jay Weiss, Marcelo Marcos Morales, Bruno Lourenço Diaz, Patricia Rieken Macêdo Rocco
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness. Despite recent advances in the understanding of its pathophysiology, asthma remains a major public health problem and, at present, there are no effective interventions capable of reversing airway remodeling. Mesenchymal stromal cell (MSC)-based therapy mitigates lung inflammation in experimental allergic asthma; however, its ability to reduce airway remodeling is limited. We aimed to investigate whether pre-treatment with eicosapentaenoic acid (EPA) potentiates the therapeutic properties of MSCs in experimental allergic asthma...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29877307/relationship-between-serum-eicosapentaenoic-acid-levels-and-j-waves-in-a-general-population-in-japan
#13
Yoshihiro Kimura, Masahiro Yamada, Kenji Hanada, Tomohide Endo, Noritomo Narita, Masato Narita, Maiko Senoo, Manabu Yonekura, Hiroaki Ichikawa, Shizuka Kurauchi, Shigeyuki Nakaji, Ken Okumura, Hirofumi Tomita
We previously showed that J-waves were found more frequently in patients with low levels of serum eicosapentaenoic acid (EPA) in the acute phase of myocardial infarction, and were associated with the incidence of ischemia-related ventricular arrhythmias. However, the relationship between J-waves and serum EPA levels in a general population remains to be elucidated.The Iwaki Health Promotion Project is an ongoing community-based health promotion study in Iwaki, Hirosaki, which is in northern Japan. A total of 1,052 residents (mean age, 53...
June 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29877283/increased-serum-dihomo-%C3%AE-linolenic-acid-levels-are-associated-with-obesity-body-fat-accumulation-and-insulin-resistance-in-japanese-patients-with-type-2-diabetes
#14
Yuya Tsurutani, Kosuke Inoue, Chiho Sugisawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
Objective To clarify the associations between serum omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acid (PUFA) levels and obesity-related metabolic abnormalities in patients with type 2 diabetes. Materials and Methods Data from 225 Japanese patients with type 2 diabetes were cross-sectionally analyzed. The serum levels of n-6 PUFAs [dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) ] and n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) were measured, and the estimated Δ-5 desaturase (D5D) activity was calculated based on the AA to DGLA ratio...
June 6, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29876120/enhancing-the-fatty-acid-profile-of-milk-through-forage-based-rations-with-nutrition-modeling-of-diet-outcomes
#15
Charles M Benbrook, Donald R Davis, Bradley J Heins, Maged A Latif, Carlo Leifert, Logan Peterman, Gillian Butler, Ole Faergeman, Silvia Abel-Caines, Marcin Baranski
Consumer demand for milk and meat from grass-fed cattle is growing, driven mostly by perceived health benefits and concerns about animal welfare. In a U. S.-wide study of 1,163 milk samples collected over 3 years, we quantified the fatty acid profile in milk from cows fed a nearly 100% forage-based diet (grassmilk) and compared it to profiles from a similar nationwide study of milk from cows under conventional and organic management. We also explored how much the observed differences might help reverse the large changes in fatty acid intakes that have occurred in the United States over the last century...
May 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29873593/variation-in-the-plasma-levels-of-polyunsaturated-fatty-acids-in-control-vis-%C3%A3-vis-nonalcoholic-fatty-liver-disease-subjects-and-its-possible-association-with-gut-microbiome
#16
Manvi Vernekar, Rekha Singhal, Kalpana Joshi, Deepak Amarapurkar
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are becoming a major cause of chronic liver diseases globally. Polyunsaturated fatty acids (PUFA) have been postulated as a potential treatment for NAFLD. They can be obtained from diet and are also endogenously synthesized by enzymes delta-6-desaturase (D6D), delta-5-desaturase, and elongases. The current study is aimed at investigating the differences in the intake and levels of plasma PUFA between NAFLD patients and controls in Asian Indians...
June 6, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29864903/eicosapentaenoic-acid-improves-endothelial-function-and-nitric-oxide-bioavailability-in-a-manner-that-is-enhanced-in-combination-with-a-statin
#17
R Preston Mason, Hazem Dawoud, Robert F Jacob, Samuel C R Sherratt, Tadeusz Malinski
The endothelium exerts many vasoprotective effects that are largely mediated by release of nitric oxide (NO). Endothelial dysfunction represents an early but reversible step in atherosclerosis and is characterized by a reduction in the bioavailability of NO. Previous studies have shown that eicosapentaenoic acid (EPA), an omega-3 fatty acid (O3FA), and statins individually improve endothelial cell function, but their effects in combination have not been tested. Through a series of in vitro experiments, this study evaluated the effects of a combined treatment of EPA and the active metabolite of atorvastatin (ATM) on endothelial cell function under conditions of oxidative stress...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29864682/non-alcoholic-fatty-liver-disease-severity-and-metabolic-complications-in-obese-children-impact-of-omega-3-fatty-acids
#18
Schohraya Spahis, Fernando Alvarez, Nejma Ahmed, Josée Dubois, Ramy Jalbout, Massimiliano Paganelli, Kelly Grzywacz, Edgard Delvin, Noel Peretti, Emile Levy
Although n-3 polyunsaturated fatty acids (PUFA) revealed promising therapeutic results in non-alcoholic fatty liver disease (NAFLD), which is considered as the most prevalent cause of chronic hepatic disease, inconsistencies are calling for further confirmatory trials to demonstrate therapeutic efficacy and safety. The study, registered as NCT02201160 on www.clinicaltrials.gov, was designed to compare two groups of NAFLD with a different severity, and to evaluate the efficacy of n-3 PUFA supplementation. Twenty young male participants of French Canadian origin with NAFLD were enrolled and classified into moderate (mNAFLD) and severe (sNAFLD) fatty liver groups, according to transaminase levels, ultrasonography, NAFLD Activity Score and Fatty Liver Index (FLI)...
April 10, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29860462/omega-3-fatty-acids-supplementation-therapeutic-potential-in-a-mouse-model-of-stargardt-disease
#19
Ekatherine Prokopiou, Panagiotis Kolovos, Maria Kalogerou, Anastasia Neokleous, Orthodoxia Nicolaou, Kleitos Sokratous, Kyriacos Kyriacou, Tassos Georgiou
Purpose: To evaluate the therapeutic effects of omega-3 (ω3) fatty acids on retinal degeneration in the ABCA4-/- model of Stargardt disease when the blood level of arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio is between 1 and 1.5. Methods: Eight-month-old mice were allocated to three groups: wild type (129S1), ABCA4-/- untreated, and ABCA4-/- ω3 treated. ω3 treatment lasted 3 months and comprised daily gavage administration of EPA and docosahexaenoic acid (DHA)...
June 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29860183/omega-3-polyunsaturated-fatty-acid-supplementation-in-prevention-and-treatment-of-maternal-depression-putative-mechanism-and-recommendation
#20
REVIEW
Mei-Chi Hsu, Chia-Yi Tung, Hsing-E Chen
BACKGROUND: Women are vulnerable to depression during their childbearing years, and giving birth to a child precipitates postpartum depression (PPD) in some women. This review focuses on comparing the effectiveness of omega-3 polyunsaturated fatty acid supplementation on depression during pregnancy or PPD after childbirth. METHODS: MEDLINE, PubMed, PsycINFO, and the Cochrane Collaboration Registry of Controlled Trials etc. through July 2017 were searched. Studies of dietary intake and plasma and/or milk levels of omega-3 fatty acids and trials of benefits and effects of omega-3 fatty acids supplements on pregnant or postpartum women with depression were specifically selected...
May 16, 2018: Journal of Affective Disorders
keyword
keyword
83034
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"