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Homocystine cardiovascular risk

A Gazdag, E V Nagy, A Erdei, M Bodor, E Berta, Z Szabó, Z Jenei
OBJECTIVE: The aim of this study was to investigate aortic stiffness and left ventricular (LV) systolic and diastolic function in patients with differentiated thyroid cancer (DTC) on thyroxine (L-T4) therapy and after L-T4 withdrawal to assess the cardiovascular impact of long-term subclinical hyperthyroidism and short-term overt hypothyroidism. METHODS: Twenty-four patients who had had total thyroidectomy and radioiodine ablation for differentiated thyroid cancer were studied on two occasions: on TSH suppressive L-T4 therapy (sTSH 0...
February 2015: Journal of Endocrinological Investigation
Rino Donghi, Plinio Amendola, Gabriele Pellicciotta, Pierfelice Bertuzzi
We studied 9145 workers allocated among Italian country employed in the same factory. Most of them were male, mean age 47,6 (20,2<x<71,9). Everybody was subjected to cardiovascular examination, electrocardiogram, blood chemistry: glycemia, total cholesterol, Hdl, Ldl, homocysteinemia, serum protein electrophoresis. BMI was lower in Lombardia than Center and South of the Country. Southern were older, we found important differences among people living in the different areas. Southern and people of the central lands had a higher cardiovascular risk than northern...
April 2011: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Bjanka Vuksan-Ćusa, Miro Jakovljević, Marina Sagud, Alma Mihaljević Peleš, Darko Marčinko, Radmila Topić, Sanea Mihaljević, Jadranka Sertić
There is accumulating evidence for an increased prevalence of metabolic syndrome (MetS) in bipolar patients, which is comparable to the prevalence of MetS in patients with schizophrenia. Hyperhomocysteinaemia has emerged as an independent and graded risk factor for the development of cardiovascular disease (CVD), which is, at the same time, the primary clinical outcome of MetS. The aim of this study was to ascertain if the presence of MetS was associated with hyperhomocysteinaemia in patients with bipolar disorder (N=36) and schizophrenia (N=46) treated with second-generation antipsychotics (SGA)...
August 30, 2011: Psychiatry Research
Michela Tomaiuolo, Gennaro Vecchione, Maurizio Margaglione, Daniela Pisanelli, Elvira Grandone
Homocysteine is an endogenous sulphydryl aminoacid irreversibly catabolized by transsulfuration to cysteine or remethylated to methionine. Increased plasma levels of homocysteine are an independent risk factor for atherosclerosis and cardiovascular disease. Accurate and reliable quantification of this amino acid in plasma samples is essential in clinical practice to explore the presence of a hyperhomocysteinemia, for instance after an ischemic event, or to control a possible adjunctive risk factor in patients at higher risk...
October 15, 2009: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Andreas Pexa, M Herrmann, O Taban-Shomal, T Henle, A Deussen
AIM: Hyperhomocysteinaemia, diagnosed by serum levels, is regarded as an independent risk indicator for cardiovascular events and is associated with various diseases. The pathomechanisms seem to be partly due to concentrations of homocysteine metabolites and their effect on the cellular transmethylation processes. METHODS: We compared two common models for experimental hyperhomocysteinaemia - high methionine diet and homocystine-enriched diet - regarding their effects on tissue concentrations of homocysteine metabolites...
September 2009: Acta Physiologica
N Koubaa, A Nakbi, M Smaoui, N Abid, R Chaaba, M Abid, M Hammami
INTRODUCTION: Total plasma homocysteine (tHcy) is an emerging risk factor for the development of atherosclerosis. However, its relationship with diabetes is still unclear. OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications. DESIGN AND METHODS: Eighty-six DM patients were compared to 120 healthy volunteers...
September 2007: Clinical Biochemistry
Alexandre C Pereira, Ayumi A Miyakawa, Neuza H M Lopes, Paulo R Soares, Sergio A de Oliveira, Luiz A M Cesar, Jose F Ramires, Whady Hueb, Jose Eduardo Krieger
INTRODUCTION: A large body of evidence links plasma homocysteine (Hcy) concentrations and cardiovascular disease. A common MTHFR polymorphism (C677T) leads to a variant with reduced activity and associated with increased Hcy levels. Coronary surgery precipitates a significant and sustained increase in the blood concentrations of Hcy and elevated levels of plasma Hcy have been associated to saphenous vein (SV) graft disease after CABG. However, the effects of MTHFR genotypes in the incidence of cardiovascular events after CABG have not been investigated prospectively...
2007: Thrombosis Research
Elvia García-López, Juan J Carrero, Mohamed E Suliman, Bengt Lindholm, Peter Stenvinkel
Patients on peritoneal dialysis (PD) are at high cardiovascular risk. Although some risk factors are unmodifiable (for example, age, sex, genetics), others are exacerbated in the unfriendly uremic milieu (inflammation, oxidative stress, mineral disturbances) or contribute per se to kidney disease and cardiovascular progression (diabetes mellitus, hypertension). Moreover, several factors associated with PD therapy may both increase (by altered lipid profile, hyperinsulinemia, and formation of advanced glycation end-products) and decrease (by better blood pressure control and anemia management) cardiovascular risk...
June 2007: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Mahmut Civilibal, Salim Caliskan, Huseyin Oflaz, Lale Sever, Cengiz Candan, Nur Canpolat, Ozgur Kasapcopur, Zehra Bugra, Nil Arisoy
Cardiovascular disease (CVD) is the principal cause of mortality in patients with end-stage renal disease (ESRD). The aim of this study was to analyze carotid intima-media thickness (cIMT), endothelium-dependent dilatation (EDD), and left ventricular mass index (LVMI) as the cardiovascular risk markers and to investigate the independent risk factors of these markers in pediatric dialysis patients. This study included 39 children and adolescents undergoing dialysis (15 hemodialysis and 24 peritoneal dialysis) and 15 age- and gender-matched healthy subjects...
July 2007: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Elzbieta Zieminska, Jerzy W Lazarewicz
Elevated homocysteine is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-evoked neurotoxicity, disturbances in methylation processes and NMDA receptor-mediated excitotoxicity have been suggested. Our previous studies demonstrated that group I metabotropic glutamate receptors along with NMDA receptors participate in acute homocysteine-induced neuronal damage. In this study, using propidium iodide staining, we tested whether the same mechanism may mediate chronic homocysteine neurotoxicity...
2006: Acta Neurobiologiae Experimentalis
Evgeniya A Angelova, Galya D Minkova, Todorka Z Tsvetkova
Over the last decade, evidence has accumulated that elevated total homocysteine (tHcy) is an independent risk factor for vascular disease. Due to the variety of Hcy determinants (age, gender, ethnicity and lifestyle), it is now recommended that the distribution of plasma Hcy concentrations should be established for different populations. Therefore the objective of our study was to evaluate a modified HPLC with fluorescence detection procedure for reliable quantification of tHcy and to demonstrate its successful application to determine the distribution of tHcy levels in healthy Bulgarians...
2006: Clinical Laboratory
I F Godsland, R S Elkeles, M D Feher, F Nugara, M B Rubens, W Richmond, M Khan, J Donovan, V Anyaoku, M D Flather
AIMS: The PREDICT Study aims to determine: (i) the association between cardiovascular risk factors and coronary artery calcification score (CACS) obtained by electron beam tomography and (ii) the predictive value of CACS for coronary heart disease (CHD) events in Type 2 diabetes. METHODS: Having previously reported relationships between CACS and conventional risk factors, we have now studied the novel risk factors, plasma high-sensitivity C-reactive protein (CRP) and homocysteine, insulin resistance, serum apoprotein A1 and B concentrations, the serum triglyceride/high-density lipoprotein cholesterol ratio and metabolic syndrome (International Diabetes Federation definition) in 573 subjects of the PREDICT Type 2 diabetes cohort...
November 2006: Diabetic Medicine: a Journal of the British Diabetic Association
Giuseppe Derosa, Arrigo F G Cicero, Angela D'Angelo, Antonio Gaddi, Leonardina Ciccarelli, Mario N Piccinni, Sibilla A T Salvadeo, Fabio Pricolo, Ilaria Ferrari, Alessia Gravina, Pietro D Ragonesi
BACKGROUND: Although the metabolic effects of the thiazolidinediones have been well studied, there is a lack of comparative data on their effects on certain cardiovascular risk factors, such as elevated plasma levels of lipoprotein (a) (Lp[a]) and homocysteine (Hcy). OBJECTIVE: This study compared the effects of pioglitazone or rosiglitazone added to glimepiride on a range of lipid parameters, focusing on Lp(a) and Hcy, in patients with type 2 diabetes mellitus and the metabolic syndrome...
May 2006: Clinical Therapeutics
Patrick W G Mallon, John Miller, Jason C Kovacic, Julia Kent-Hughes, Richard Norris, Katherine Samaras, Michael P Feneley, David A Cooper, Andrew Carr
OBJECTIVES: To determine the effect of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pravastatin, on markers of cardiovascular risk and lipodystrophy in HIV-infected, protease inhibitor (PI)-treated men with hypercholesterolaemia. METHODS: A randomized, placebo-controlled, 16-week study was carried out on 33 HIV-infected, hypercholesterolaemic men (fasting total cholesterol > 6.5 mmol/L) on PI-containing therapy. Patients commenced dietary assessment and advice at week 0 and were randomized to 12 weeks pravastatin (40 mg each night) or placebo from week 4...
April 24, 2006: AIDS
M R Graham, F M Grace, W Boobier, D Hullin, A Kicman, D Cowan, B Davies, J S Baker
OBJECTIVES: The long term effects (>20 years) of anabolic-androgenic steroid (AAS) use on plasma concentrations of homocysteine (HCY), folate, testosterone, sex hormone binding globulin (SHBG), free androgen index, urea, creatinine, haematocrit (HCT), vitamin B12, and urinary testosterone/epitestosterone (T/E) ratio, were examined in a cohort of self-prescribing bodybuilders. METHODS: Subjects (n = 40) were divided into four distinct groups: (1) AAS users still using AAS (SU; n = 10); (2) AAS users abstinent from AAS administration for 3 months (SA; n = 10); (3) non-drug using bodybuilding controls (BC; n = 10); and (4) sedentary male controls (SC; n = 10)...
July 2006: British Journal of Sports Medicine
Beatrix Büdy, RoseMarie O'Neill, Patricia M DiBello, Shantanu Sengupta, Donald W Jacobsen
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Transport of L-homocysteine into and out of the human vascular endothelium is poorly understood. We hypothesized that cultured human aortic endothelial cells (HAEC) would import L-homocysteine on one or more of the L-cysteine transport systems. Inhibitors of the transporters were used to characterize the uptake of [35S]L-homocysteine, [35S]L-homocystine, and [35S]L-cysteine. We found that L-homocysteine uptake is mediated by the sodium-dependent cysteine transport systems X(AG), ASC, and A, and the sodium-independent transport system L...
February 15, 2006: Archives of Biochemistry and Biophysics
Leonie G Mikael, Jacques Genest, Rima Rozen
Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional or genetic disturbances in homocysteine metabolism. A polymorphism in methylenetetrahydrofolate reductase (MTHFR) is the most common genetic cause of mild hyperhomocysteinemia. To examine mechanisms by which an elevation in plasma homocysteine leads to vascular disease, we first performed microarray analyses in livers of Mthfr-deficient mice and identified differentially expressed genes that are involved in lipid and cholesterol metabolism...
March 3, 2006: Circulation Research
Katharina Schroecksnadel, Barbara Frick, Christiana Winkler, Barbara Wirleitner, Günter Weiss, Dietmar Fuchs
Hyperhomocysteinemia is regarded as an independent risk factor for vascular diseases, and homocysteine is supposed to contribute to oxidative stress and endothelial damage. Statin therapy is an established intervention to reduce the risk of acute events in patients suffering from cardiovascular diseases. Apart from their lipid-lowering capacity, statins also exert anti-inflammatory and antioxidant effects. As cellular immune activation and oxidative stress play a major role in the pathogenesis of cardiovascular diseases, the anti-inflammatory capacity of statins could partly be responsible for the beneficial effects observed in patients...
2005: Clinical Chemistry and Laboratory Medicine: CCLM
Julie Robertson, Francesco Iemolo, Sally P Stabler, Robert H Allen, J David Spence
BACKGROUND: Carotid plaque area is a strong predictor of cardiovascular events. High homocysteine levels, which are associated with plaque formation, can result from inadequate intake of folate and vitamin B12. Now that folic acid fortification is widespread in North America, vitamin B12 has become an important determinant of homocysteine levels. We sought to determine the prevalence of low serum levels of vitamin B12, and their relation to homocysteine levels and carotid plaque area among patients referred for treatment of vascular disease since folic acid fortification of enriched grain products...
June 7, 2005: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
D Giustarini, S Lorenzini, R Rossi, D Chindamo, P Di Simplicio, R Marcolongo
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic inflammatory disease which involves the synovial membrane of multiple diarthroidal joints causing damage to cartilage and bones. The damage process seems to be related to an overproduction of oxygen reactive species inducing an oxidative perturbation. Since sulfhydryl groups are primary antioxidant factors, we were interested in investigating the balance of plasma sulfhydryl/disulfides in patients with active RA compared to healthy control subjects...
March 2005: Clinical and Experimental Rheumatology
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