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https://www.readbyqxmd.com/read/29782325/early-emotional-attention-is-impacted-in-alzheimer-s-disease-an-eye-tracking-study
#1
Jessica Bourgin, Nathalie Guyader, Alan Chauvin, Alexandra Juphard, Mathilde Sauvée, Olivier Moreaud, Laetitia Silvert, Pascal Hot
Emotional deficits have been repetitively reported in Alzheimer's disease (AD) without clearly identifying how emotional processing is impaired in this pathology. This paper describes an investigation of early emotional processing, as measured by the effects of emotional visual stimuli on a saccadic task involving both pro (PS) and anti (AS) saccades. Sixteen patients with AD and 25 age-matched healthy controls were eye-tracked while they had to quickly move their gaze toward a positive, negative, or neutral image presented on a computer screen (in the PS condition) or away from the image (in the AS condition)...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781927/a-case-of-corneal-neovascularization-misdiagnosed-as-total-limbal-stem-cell-deficiency
#2
Qihua Le, C Michael Samson, Sophie X Deng
PURPOSE: To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). METHODS: This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29780936/clinical-and-pathological-correlation-of-cotton-wool-spots-in-secondary-angle-closure-glaucoma
#3
Anand Bhatt, Christine Nguyen, Sameh Mosaed, Don Minckler
Purpose: Cotton Wool Spots (CWS) are a commonly described retinal finding in the posterior segment associated with an extensive number of systemic diseases. The appearance of a CWS in the setting of glaucoma has rarely been reported and has not been correlated with pathology to localized loss of the nerve fiber layer previously. In this case report, we augment a previous report of an 18 year old female with a diagnosis of low grade ciliary body melanoma. This patient experienced eventual mechanical angle closure with a CWS appearing in the posterior pole in the setting of acute elevation of intraocular pressure (IOP)...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29779683/strabismus-strabismus-surgery-and-reoperation-rate-in-the-united-states-analysis-from-the-iris-registry
#4
Michael X Repka, Flora Lum, Bhavya Burugapalli
PURPOSE: To describe the rates of strabismus, strabismus surgery, and strabismus surgery reoperations among all age groups in the United States. DESIGN: Retrospective analysis of electronic health record data. PARTICIPANTS: Patients from the IRIS (Intelligent Research in Sight) Registry. METHODS: Description of the types and rates of strabismus and strabismus surgery from 2013 to 2016 with subgroups by age, sex, race/ethnicity, and region of the United States...
May 17, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29779188/vitreomacular-interface-abnormalities-in-patients-with-diabetic-macular-oedema-and-their-implications-on-the-response-to-anti-vegf-therapy
#5
Michael Mikhail, Stephen Stewart, Felicia Seow, Ruth Hogg, Noemi Lois
PURPOSE: To determine whether the presence of vitreomacular interface abnormalities (VMIA) in patients with diabetic macular oedema (DMO) modifies the response to ranibizumab. METHODS: Medical records and spectral-domain optical coherence tomography (SD-OCT) scans of consecutive patients with centre-involving DMO initiating therapy with ranibizumab between December 2013 and March 2014 at the Belfast Health and Social Care Trust were reviewed. Patients were identified through an electronic database...
May 19, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29777044/the-impact-of-sign-glaucoma-guidelines-on-false-positive-referrals-from-community-optometrists-in-central-scotland
#6
Samantha Sii, Ahmad Nasser, Cheng Yi Loo, Catherine Croghan, Alan Rotchford, Pankaj Kumar Agarwal
BACKGROUND: Since the introduction of National Institute for Health and Care Excellence glaucoma guidelines 2009, the number of referrals from community optometrists to hospital eye services has increased across the UK, resulting in increase in first visit discharge rates (FVDRs). AIM: To assess the impact of Scottish Intercollegiate Guidelines Network (SIGN) 144 on quality of referrals from community optometrists. METHODOLOGY: A retrospective study of patient records who attended as new adult glaucoma referrals to clinics in Princess Alexandra Eye Pavilion, Edinburgh, and in Greater Glasgow and Clyde, was carried out across October-November 2014 (group 1) and September-October 2016 (group 2), before and after the introduction of SIGN 144...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29776671/guidelines-on-diabetic-eye-care-the-international-council-of-ophthalmology-recommendations-for-screening-follow-up-referral-and-treatment-based-on-resource-settings
#7
REVIEW
Tien Y Wong, Jennifer Sun, Ryo Kawasaki, Paisan Ruamviboonsuk, Neeru Gupta, Van Charles Lansingh, Mauricio Maia, Wanjiku Mathenge, Sunil Moreker, Maji M K Muqit, Serge Resnikoff, Juan Verdaguer, Peiquan Zhao, Frederick Ferris, Lloyd P Aiello, Hugh R Taylor
Diabetes mellitus (DM) is a global epidemic and affects populations in both developing and developed countries, with differing health care and resource levels. Diabetic retinopathy (DR) is a major complication of DM and a leading cause of vision loss in working middle-aged adults. Vision loss from DR can be prevented with broad-level public health strategies, but these need to be tailored to a country's and population's resource setting. Designing DR screening programs, with appropriate and timely referral to facilities with trained eye care professionals, and using cost-effective treatment for vision-threatening levels of DR can prevent vision loss...
May 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29774966/test-characteristics-of-point-of-care-ultrasound-for-the-diagnosis-of-retinal-detachment-in-the-emergency-department
#8
Daniel J Kim, Mario Francispragasam, Gavin Docherty, Byron Silver, Ross Prager, Donna Lee, David Maberley
Previous studies of point of care ultrasound (POCUS) have reported high sensitivities and specificities for retinal detachment (RD). Our primary objective was to assess the test characteristics of POCUS performed by a large heterogeneous group of emergency physicians (EPs) for the diagnosis of RD. METHODS: This was a prospective diagnostic test assessment of POCUS performed by EPs with varying ultrasound experience on a convenience sample of emergency department (ED) patients presenting with flashes or floaters in one or both eyes...
May 18, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29774584/-i-can-see-fine-patient-knowledge-of-eye-care
#9
Elizabeth L Irving, Alisa M Sivak, Marlee M Spafford
PURPOSE: To learn more about the perceptions and attitudes toward eye care of members of the public - in particular, their knowledge of the purpose, components and providers of eye examinations, their ability to self-monitor ocular status and their awareness of major sight threatening eye conditions. METHODS: This study used the qualitative research strategy, grounded theory. Participants were recruited via poster and social media. Two researchers, one with optometric knowledge and one without, moderated seven 60- to 90-min, semi-structured focus group discussions, which were audiotaped and transcribed...
May 17, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29772496/vibrotactile-feedback-alters-dynamics-of-static-postural-control-in-persons-with-parkinson-s-disease-but-not-older-adults-at-high-fall-risk
#10
Carleigh M High, Hannah F McHugh, Stephen C Mills, Shinichi Amano, Jane E Freund, Srikant Vallabhajosula
BACKGROUND: Aging and Parkinson's disease are often associated with impaired postural control. Providing extrinsic feedback via vibrotactile sensation could supplement intrinsic feedback to maintain postural control. RESEARCH QUESTION: We investigated the postural control response to vibrotactile feedback provided at the trunk during challenging stance conditions in older adults at high fall risk and individuals with Parkinson's disease compared to healthy older adults...
May 8, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29771756/thyrotropin-receptor-antibodies-an-overview
#11
Anupam Kotwal, Marius Stan
PURPOSE: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. METHODS: We reviewed and analyzed the literature reporting TRAb assays and their clinical utility...
May 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29769509/joubert-s-syndrome-a-report-of-two-cases
#12
M M Rahman, S M Rahman
Joubert's syndrome and related disorders are primarily disorder of cerebellar development. It has heterogeneity of presentation that varies from patient to patient. In the recent past we encountered a pair of children who presented with developmental delay, hypotonia and abnormal eye movements. Classic Joubert's syndrome was confirmed on the basis of clinical and neuro-imaging findings. So careful clinical assessment and appropriate neuro-imaging should be done in suspected cases for confirmation of diagnosis...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29766541/gold-nanoparticles-in-ophthalmology
#13
REVIEW
Florence Masse, Mathieu Ouellette, Guillaume Lamoureux, Elodie Boisselier
Many research projects are underway to improve the diagnosis and therapy in ophthalmology. Indeed, visual acuity deficits affect 285 million people worldwide and different strategies are being developed to strengthen patient care. One of these strategies is the use of gold nanoparticles (GNP) for their multiple properties and their ability to be used as both diagnosis and therapy tools. This review exhaustively details research developing GNPs for use in ophthalmology. The toxicity of GNPs and their distribution in the eye are described through in vitro and in vivo studies...
May 16, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29765954/an-unusual-presentation-of-esthesioneuroblastoma-in-a-young-pregnant-female
#14
Meenakshi Wadhwani, Amar Ranjan, Kulbhushan Gangwani, Prasenjit Das
Background: Esthesioneuroblastoma is a rare neuroepithelial tumor arising from the olfactory epithelium in the cribriform plate or nasal cavity. It accounts for 1-5% of cases of malignant neoplasms of the nasal cavity. Methods: A 20-year-old pregnant female presented with painful loss of vision in both eyes, on imaging diagnosed as meningioma. There was a progressive increase in pain along with diminution of vision to the extent of complete loss of vision in the right eye...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29763344/from-the-valley-of-death-to-the-crossroads-of-opportunity-a-discussion-of-evolving-benefit-risk-evaluation-standards
#15
Peter J Pitts, Patrick Brady
A series of recent US Food and Drug Administration (FDA) approvals (such as Sarepta's Exondys 51, Merck's Keytruda, and Portola's Bevyxxa) has generated significant interest within the drug development ecosystem. Facilitated regulatory pathways aimed toward expediting medicines to patients suffering from serious and life-threatening conditions are a good thing, even if it raises curiosity and introduces some degree of uncertainty. Over the last 20 years, two key words in drug development have been speed and innovation...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29759124/the-seronegative-spondyloarthropathies
#16
REVIEW
Ayyappa S Duba, Stephanie D Mathew
The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Early recognition and referral are key to limit disability, and comanagement with primary care and rheumatology offers the best outcomes.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29758069/strengthening-primary-eye-care-in-south-africa-an-assessment-of-services-and-prospective-evaluation-of-a-health-systems-support-package
#17
Rivka R Lilian, Jean Railton, Erik Schaftenaar, Moyahabo Mabitsi, Cornelis J Grobbelaar, N Sellina Khosa, Babra H Maluleke, Helen E Struthers, James A McIntyre, Remco P H Peters
Visual impairment is a significant public health concern, particularly in low- and middle-income countries where eye care is predominantly provided at the primary healthcare (PHC) level, known as primary eye care. This study aimed to perform an evaluation of primary eye care services in three districts of South Africa and to assess whether an ophthalmic health system strengthening (HSS) package could improve these services. Baseline surveys were conducted in Cape Winelands District, Johannesburg Health District and Mopani District at 14, 25 and 36 PHC facilities, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29754589/orbital-t-cell-lymphoma-in-youngest-recorded-patient-early-diagnosis-management-and-successful-outcome-a-case-report-and-review-of-the-literature
#18
Hind Manaa Alkatan, Saleh Hamad Alrashed, Ammar C Al-Rikabi, Yasser H Al-Faky
BACKGROUND: Primary orbital peripheral T-cell lymphoma, not otherwise specified is an exceedingly rare disorder with a very poor outcome, and to the best of our knowledge only a few cases have been reported in the English literature. We present the youngest reported case describing the successful outcome after management with a thorough review of the English literature of all the reported cases of primary peripheral T-cell lymphoma, not otherwise specified. CASE PRESENTATION: Our patient is a 3-year-old Syrian boy who presented with gradual progressive orbital swelling...
May 14, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29753915/the-eyes-reveal-uncertainty-about-object-distinctions-in-semantic-variant-primary-progressive-aphasia
#19
Andreia V Faria, David Race, Kevin Kim, Argye E Hillis
At least three distinct variants of primary progressive aphasia (PPA) have been described, but they are difficult to distinguish early in the course, when individuals experience primarily anomia. People with svPPA are often the hardest to care for, because they have impaired comprehension of words and objects and often have negative changes in comportment. We sought to identify an early marker of semantic variant primary progressive aphasia (svPPA) and to enhance the understanding of the semantic deficit in svPPA...
April 3, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29751329/determination-of-metals-and-pharmaceutical-compounds-released-in-hospital-wastewater-from-toluca-mexico-and-evaluation-of-their-toxic-impact
#20
Itzayana Pérez-Alvarez, Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Damià Barceló, Miren López De Alda, Sandra Pérez Solsona, Livier Sánchez-Aceves, Nely SanJuan-Reyes, Marcela Galar-Martínez
Due to the activities inherent to medical care units, the hospital effluent released contains diverse contaminants such as tensoactives, disinfectants, metals, pharmaceutical products and chemical reagents, which are potentially toxic to the environment since they receive no treatment or are not effectively removed by such treatment before entering the drain. They are incorporated into municipal wastewater, eventually entering water bodies where they can have harmful effects on organisms and can result in ecological damage...
May 8, 2018: Environmental Pollution
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