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https://www.readbyqxmd.com/read/27910560/mitigation-of-hard-x-ray-background-in-backlit-pinhole-imagers
#1
J R Fein, P A Keiter, J P Holloway, S R Klein, J S Davis, R P Drake
Experiments were performed to mitigate the hard x-ray background commonly observed in backlit pinhole imagers. The material of the scaffold holding the primary backlighter foil was varied to reduce the laser-plasma instabilities responsible for hot electrons and resulting hard x-ray background. Radiographic measurements with image plates showed a factor of >25 decrease in x-rays between 30 and 67 keV when going from a plastic to Al or V scaffold. A potential design using V scaffold offers a signal-to-background ratio of 6:1, a factor of 2 greater than using the bare plastic scaffold...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910335/detailed-characterization-of-the-llnl-imaging-proton-spectrometer
#2
A M Rasmus, A U Hazi, M J-E Manuel, C C Kuranz, S R Klein, P X Belancourt, J R Fein, M J MacDonald, R P Drake, B B Pollock, J Park, G J Williams, H Chen
Ultra-intense short pulse lasers incident on solid targets (e.g., thin Au foils) produce well collimated, broad-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields, and density gradients in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built [H. Chen et al., Rev. Sci. Instrum. 81, 10D314 (2010)] for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27862905/intranasal-fentanyl-for-initial-treatment-of-vaso-occlusive-crisis-in-sickle-cell-disease
#3
Daniel M Fein, Jeffrey R Avner, Kathryn Scharbach, Deepa Manwani, Hnin Khine
BACKGROUND: Analgesia administration for children with vaso-occlusive crises is often delayed in the emergency department. Intranasal fentanyl (INF) has been shown to be safe and effective in providing rapid analgesia for other painful conditions. Our objective was to determine if children with a vaso-occlusive crisis (VOC) who received initial treatment with INF compared to placebo achieved a greater decrease in pain score after 20 min. PROCEDURE: This was a randomized, double-blind, placebo-controlled trial...
November 10, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27832140/the-effects-of-compensatory-auditory-stimulation-and-high-definition-transcranial-direct-current-stimulation-hd-tdcs-on-tinnitus-perception-a-randomized-pilot-study
#4
Simon Henin, Dovid Fein, Eric Smouha, Lucas C Parra
BACKGROUND: Tinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound. OBJECTIVE: The purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the tinnitus percept acutely using customized auditory stimulation. To further enhance the effects of auditory stimulation, this intervention was paired with high-definition transcranial direct current stimulation (HD-tDCS)...
2016: PloS One
https://www.readbyqxmd.com/read/27798263/cancer-cells-induce-metastasis-supporting-neutrophil-extracellular-dna-traps
#5
Juwon Park, Robert W Wysocki, Zohreh Amoozgar, Laura Maiorino, Miriam R Fein, Julie Jorns, Anne F Schott, Yumi Kinugasa-Katayama, Youngseok Lee, Nam Hee Won, Elizabeth S Nakasone, Stephen A Hearn, Victoria Küttner, Jing Qiu, Ana S Almeida, Naiara Perurena, Kai Kessenbrock, Michael S Goldberg, Mikala Egeblad
Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular traps (NETs). These are pathogen-trapping structures generated by expulsion of the neutrophil's DNA with associated proteolytic enzymes. NETs produced by infection can promote cancer metastasis. We show that metastatic breast cancer cells can induce neutrophils to form metastasis-supporting NETs in the absence of infection. Using intravital imaging, we observed NET-like structures around metastatic 4T1 cancer cells that had reached the lungs of mice...
October 19, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27782813/additive-value-of-pre-operative-and-one-month-post-operative-lymphocyte-count-for-death-risk-stratification-in-patients-with-resectable-pancreatic-cancer-a-multicentric-study
#6
Christelle d'Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb, Philippe Bachellier, Christophe Borg
BACKGROUND: Pancreatic adenocarcinoma (PDAC) incidence is increasing worldwide. Several studies have shown that lymphopenia was correlated with a poor prognosis but the potential interest to measure lymphopenia in the pre and post-operative setting as well as its added value among conventional prognostic factors was never investigated. METHODS: Data from two independent cohorts in whom patients underwent resection for pancreatic carcinoma were retrospectively recorded...
October 26, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27743321/factor-analysis-of-the-childhood-autism-rating-scale-in-a-sample-of-two-year-olds-with-an-autism-spectrum-disorder
#7
Emily Moulton, Kathryn Bradbury, Marianne Barton, Deborah Fein
The Childhood Autism Rating Scale (CARS), (Schopler et al. in J Autism Dev Disord 10(1):91-103, 1980) is a 15-item observation-based rating scale that yields a total score reflective of autism symptom severity. This study investigated the factor structure of the CARS in a sample of 2-year-old children with DSM-IV-TR (American Psychiatric Association in Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Publishing, Washington, 2000) diagnoses of AD or PDD-NOS. Following a preliminary internal cross-validation, principal axis factor analysis was completed (N = 282)...
October 14, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27741067/are-graduating-pediatric-residents-prepared-to-perform-infant-lumbar-punctures-a-multi-institutional-descriptive-study
#8
Marc A Auerbach, Marjorie Lee White, Sweta Bhargava, Pavan Zaveri, Elizabeth B Seelbach, Rebekah A Burns, Renuka Mehta, Brett McAninch, Daniel Fein, Todd P Chang, David O Kessler
OBJECTIVES: Few published studies describe graduating pediatric residents' procedural skills or success rates. This information would help guide supervisors' decisions about graduating residents' preparedness, training, and supervision needs. This study aimed to measure success rates for graduating pediatric residents performing infant lumbar puncture (LP) during the final months of their training and to describe their experiences performing and supervising infant LPs during the course of their training...
October 6, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27705180/preschool-predictors-of-school-age-academic-achievement-in-autism-spectrum-disorder
#9
Lauren E Miller, Jeffrey D Burke, Eva Troyb, Kelley Knoch, Lauren E Herlihy, Deborah A Fein
OBJECTIVE: Characterization of academic functioning in children with autism spectrum disorder (ASD), particularly predictors of achievement, may have important implications for intervention. The current study aimed to characterize achievement profiles, confirm associations between academic ability and concurrent intellectual and social skills, and explore preschool predictors of school-age academic achievement in a sample of children with ASD. METHOD: Children with ASD (n = 26) were evaluated at the approximate ages of two, four, and ten...
October 5, 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27696583/yield-and-complications-of-kidney-biopsies-over-two-decades-in-a-tertiary-pediatric-center
#10
Roei Hod Feins, Anna Tobar, Miriam Davidovits
BACKGROUND: Kidney biopsy serves as an adjunct for the diagnosis of renal disease. However, it is not always productive. This study evaluated the yield and risks of kidney biopsies performed in 1995-2014 at a tertiary pediatric medical center. METHODS: The medical files of all patients who underwent closed percutaneous biopsy for various indications in native or transplanted kidneys were retrospectively reviewed for patient characteristics, technical and histopathologic findings, biopsy yield, and biopsy complications...
October 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27676519/p1-33-afatinib-versus-chemotherapy-for-egfr%C3%A2-mutation-positive-nsclc-patients%C3%A2-aged-%C3%A2-65-years-subgroup-analysis-of-lux-lung-3-6-track-advanced-nsclc
#11
Luis Fein, Yi-Long Wu, Lecia V Sequist, Sarayut L Geater, Sergey Orlov, Ki Hyeong Lee, Chun-Ming Tsai, Terufumi Kato, Katsuyuki Kiura, Carlos H Barrios, Martin Schuler, Vera Hirsh, Nobuyuki Yamamoto, Kenneth O'Byrne, Tony Mok, Dan Massey, Angela Märten, James Chih-Hsin Yang
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27668921/script-concordance-testing-to-determine-infant-lumbar-puncture-practice-variation
#12
Nnenna Ogochukwu Chime, Martin V Pusic, Marc Auerbach, Renuka Mehta, Daniel J Scherzer, Wendy Van Ittersum, Brett McAninch, Daniel M Fein, Elizabeth Seelbach, Pavan Zaveri, Jennifer M Jackson, David Kessler, Todd P Chang
OBJECTIVES: Script concordance testing (SCT) is used to assess clinical decision-making. We explore the use of SCT to (1) quantify practice variations in infant lumbar puncture (LP) and (2) analyze physician's characteristics affecting LP decision making. METHODS: Using standard SCT processes, a panel of pediatric subspecialty physicians constructed 15 infant LP case vignettes, each with 2 to 4 SCT questions (a total of 47). The vignettes were distributed to pediatric attending physicians and fellows at 10 hospitals within the INSPIRE Network...
September 23, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27660932/systemic-lupus-erythematosus-does-not-increase-risk-of-adverse-events-in-the-first-6-months-after-total-knee-arthroplasty
#13
Arielle W Fein, Caroline A Figgie, Taylor R Dodds, Joshua Wright-Chisem, Michael L Parks, Lisa A Mandl, Edwin P Su, Jane E Salmon, David J Mayman, Yuo-Yu Lee, Mark P Figgie, Susan M Goodman
BACKGROUND: Increasing numbers of patients with systemic lupus erythematosus (SLE) are undergoing total knee arthroplasty (TKA). Whether postsurgical adverse events (AEs) are higher in patients with SLE than patients with osteoarthritis (OA) is unknown. OBJECTIVES: This study aims to compare AEs within 6 months of TKA. METHODS: Patients in a single institution's arthroplasty and SLE registries who underwent TKA from 2007 to 2014 were eligible...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27628939/cognitive-and-adaptive-skills-in-toddlers-who-meet-criteria-for-autism-in-dsm-iv-but-not-dsm-5
#14
Dasal Tenzin Jashar, Laura A Brennan, Marianne L Barton, Deborah Fein
The current study compared adaptive and cognitive skills, and autism severity of toddlers with an autism spectrum disorder (ASD) diagnosis under DSM-IV but not DSM-5 criteria (DSM-IV only group) to those who met autism criteria under both diagnostic systems (DSM-5 group) and to those without ASD (non-ASD group). The toddlers in the DSM-IV only group were less delayed on various domains of adaptive (Communication, Socialization) and cognitive (Expressive and Receptive language, Fine Motor, Visual Reception) skills, and had less severe symptoms of ASD than the DSM-5 group...
December 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27602526/bacterial-associates-of-hyalesthes-obsoletus-hemiptera-cixiidae-the-insect-vector-of-bois-noir-disease-with-a-focus-on-cultivable-bacteria
#15
Lilach Iasur-Kruh, Vered Naor, Tirtza Zahavi, Matthew J Ballinger, Rakefet Sharon, Wyatt E Robinson, Steve J Perlman, Einat Zchori-Fein
The planthopper Hyalesthes obsoletus (Hemiptera: Cixiidae) is an important vector of phytoplasma diseases in grapevine. In the current study, the bacterial community compositions of symbionts of this insect were examined. Two dominant bacterial lineages were identified by mass sequencing: the obligate symbiont Candidatus Sulcia, and a facultative symbiont that is closely related to Pectobacterium sp. and to BEV, a cultivable symbiont of another phytoplasma vector, the leafhopper Euscelidius variegatus. In addition, one bacterium was successfully isolated in this study - a member of the family Xanthomonadaceae that is most closely related to the genus Dyella...
September 4, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27600470/complete-response-to-aflibercept-folfiri-in-one-patient-with-colorectal-cancer-refractory-to-bevacizumab-folfox-a-possible-autocrine-vascular-endothelial-growth-factor-receptor-2-related-mechanism
#16
Stefano Kim, Anne Cayre, Marine Jary, Marion Jacquin, Francine Arbez-Gindre, Francine Fein, Zaher Lakkis, Thierry Nguyen, Christophe Borg
No abstract text is available yet for this article.
August 9, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27571110/pulmonary-hypertension-due-to-common-respiratory-conditions-classification-evaluation-and-management-strategies
#17
REVIEW
Daniel G Fein, Ali N Zaidi, Roxana Sulica
Pulmonary hypertension (PH) due to chronic respiratory disease and/or hypoxia is classified as World Health Organization (WHO) Group III pulmonary hypertension. The patients most commonly encountered in clinical practice with group III PH include those with chronic obstructive lung disease (COPD), diffuse parenchymal lung disease, and sleep-disordered breathing. The purpose of this review is to outline the variable clinical significance of pulmonary hypertension in the most common pulmonary disease states and how a clinician may approach the management of these patients...
August 26, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27570163/experience-with-the-cardiac-surgery-simulation-curriculum-results-of-the-resident-and-faculty-survey
#18
Nahush A Mokadam, James I Fann, George L Hicks, Jonathan C Nesbitt, Harold M Burkhart, John V Conte, Daniel N Coore, Paul S Ramphal, K Robert Shen, Jennifer D Walker, Richard H Feins
BACKGROUND: The Cardiac Surgery Simulation Curriculum was developed at 8 institutions from 2010 to 2013. A total of 27 residents were trained by 18 faculty members. A survey was conducted to gain insight into the initial experience. METHODS: Residents and faculty were sent a 72- and 68-question survey, respectively. In addition to demographic information, participants reported their view of the overall impact of the curriculum. Focused investigation into each of the 6 modules was obtained...
August 20, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27570162/simulation-based-training-in-cardiac-surgery
#19
Richard H Feins, Harold M Burkhart, John V Conte, Daniel N Coore, James I Fann, George L Hicks, Jonathan C Nesbitt, Paul S Ramphal, Sharon E Schiro, K Robert Shen, Amaanti Sridhar, Paul W Stewart, Jennifer D Walker, Nahush A Mokadam
BACKGROUND: Operating room surgical training has significant limitations. This study hypothesized that some skills could be learned efficiently and safely by using simulation with component task training, deliberate practice, progressive complexity, and experienced coaching to produce safer cardiac surgeons. METHODS: Training modules included cardiopulmonary bypass, coronary artery bypass grafting, aortic valve replacement, massive air embolism, acute intraoperative aortic dissection, and sudden deterioration in cardiac function...
August 20, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27565085/chest-wall-ewing-sarcoma-a-population-based-analysis
#20
Andrew J Jacobs, Joanna Fishbein, Carolyn Fein Levy, Richard D Glick
BACKGROUND: The globally low incidence of pediatric chest wall Ewing sarcoma (CWES) has limited prior studies of this disease to mostly small, single-institution reviews. Our objective was to assess incidence, demographics, treatment patterns, and long-term survival of this disease through a population-based analysis. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results database was used to identify patients aged 0-21 y diagnosed with CWES from 1973 to 2011...
August 2016: Journal of Surgical Research
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