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https://www.readbyqxmd.com/read/28181279/validation-of-the-acute-leukemia-ebmt-score-for-prediction-of-mortality-following-allogeneic-stem-cell-transplantation-in-a-multi-center-gitmo-cohort
#1
Roni Shouval, Francesca Bonifazi, Joshua Fein, Cristina Boschini, Elena Oldani, Myriam Labopin, Roberto Raimondi, Nicoletta Sacchi, Osamah Dabash, Ron Unger, Mohamad Mohty, Alessandro Rambaldi, Arnon Nagler
Predictive models may help in determining the risk/benefit ratio of allogeneic hematopoietic stem cell transplantation (HSCT) in acute leukemia (AL). Using a machine-learning algorithm we have previously developed the AL- European Society for Blood and Marrow Transplantation (EBMT) score for prediction of mortality following transplantation. We report here the first external validation of the AL-EBMT score in a cohort of AL patients from the Italian national transplantation network (GITMO). A total of 1,848 patients transplanted between the years 2000-2014 were analyzed...
February 9, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28150188/customized-smartpeg-for-measurement-of-resonance-frequency-of-mini-dental-implants
#2
Jagjit Singh Dhaliwal, Rubens F Albuquerque, Ali Fakhry, Sukhbir Kaur, Jocelyne S Feine
BACKGROUND: One-piece narrow diameter implants (NDIs) have been recommended as "Single-tooth replacements in the anterior zones, single posterior, multiple-unit fixed dental prosthesis (FDP), edentulous jaws to be rehabilitated with FDP, and edentulous jaws rehabilitation with overdentures in situations with reduced mesiodistal space or reduced ridge width." (ITI consensus 2013). Since NDIs can be immediately loaded, it is important to be able to carry out stability testing. We developed and validated a customized SmartPeg for this type of implant to measure the Implant Stability Quotient (ISQ)...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28121978/a-vibrating-cold-device-to-reduce-pain-in-the-pediatric-emergency-department-a-randomized-clinical-trial
#3
Debra Ann Potts, Katherine Finn Davis, Okan U Elci, Joel A Fein
OBJECTIVE: Pain of intravenous (IV) catheter insertion can be mitigated with appropriate analgesia, thereby avoiding unnecessary distress. Our objective was to compare the self-reported pain of IV catheter insertion in children when using a vibrating cold device (VCD) versus standard of care 4% topical lidocaine cream (TL). METHODS: This was a 2-arm randomized controlled noninferiority trial with a convenience sample of 4- to 18-year-olds requiring nonemergent IV catheter insertion...
January 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28121237/screening-to-identify-groups-of-pediatric-emergency-department-patients-using-latent-class-analysis-of-reported-suicidal-ideation-and-behavior-and-non-suicidal-self-injury
#4
Joanna Herres, Tamar Kodish, Joel Fein, Guy Diamond
Latent class analysis of medical records data from 3,523 emergency department (ED) patients (ages 14-24; 31% Caucasian; 67% female) distinguished six groups with varying histories of suicidal ideation and behavior based on items endorsed on the Behavioral Health Screen, a web based, nurse-initiated screening tool. As expected, the more severe suicidality groups reported higher levels of depressive symptoms, traumatic distress, and substance abuse symptoms. Findings support the validity of the BHS and its utility as a medical decision tool to help ED staff evaluate the severity of patients' suicidality...
January 25, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28107737/contrast-enhanced-spectral-mammography-cesm-versus-mri-in-the-high-risk-screening-setting-patient-preferences-and-attitudes
#5
Jordana Phillips, Matthew M Miller, Tejas S Mehta, Valerie Fein-Zachary, Audrey Nathanson, Wendy Hori, Rita Monahan-Earley, Priscilla J Slanetz
PURPOSE: Our study evaluates patient preferences toward screening CESM versus MRI. MATERIALS AND METHODS: As part of a prospective study, high-risk patients had breast MRI and CESM. Patients completed an anonymous survey to evaluate preferences regarding the two modalities. RESULTS: 88% of participants completed the survey. 79% preferred CESM over MRI if the exams had equal sensitivity. 89% would be comfortable receiving contrast as part of an annual screening test...
March 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28042974/-didn-t-i-just-say-that-comparing-parent-report-and-spontaneous-speech-as-indicators-of-grammatical-development
#6
Manya Jyotishi, Deborah A Fein, Letitia R Naigles
BACKGROUND: The Vineland Adaptive Behavior Scales use parental report to examine communication and social skills in children with typical and atypical development, and exhibit high reliability when compared against overall direct testing. However, findings are mixed comparing Vineland communication/language scores with experimenter-administered tests of language. METHODS: The current study breaks new ground in comparing Vineland reports with direct observation of children's speech by (a) individual items and (b) level of child functioning, focusing on usage of wh-questions, verb tenses, negation, pronouns and noun-verb combinations...
February 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27910560/mitigation-of-hard-x-ray-background-in-backlit-pinhole-imagers
#7
J R Fein, P A Keiter, J P Holloway, S R Klein, J S Davis, R P Drake
Experiments were performed to mitigate the hard x-ray background commonly observed in backlit pinhole imagers. The material of the scaffold holding the primary backlighter foil was varied to reduce the laser-plasma instabilities responsible for hot electrons and resulting hard x-ray background. Radiographic measurements with image plates showed a factor of >25 decrease in x-rays between 30 and 67 keV when going from a plastic to Al or V scaffold. A potential design using V scaffold offers a signal-to-background ratio of 6:1, a factor of 2 greater than using the bare plastic scaffold...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910335/detailed-characterization-of-the-llnl-imaging-proton-spectrometer
#8
A M Rasmus, A U Hazi, M J-E Manuel, C C Kuranz, S R Klein, P X Belancourt, J R Fein, M J MacDonald, R P Drake, B B Pollock, J Park, G J Williams, H Chen
Ultra-intense short pulse lasers incident on solid targets (e.g., thin Au foils) produce well collimated, broad-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields, and density gradients in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built [H. Chen et al., Rev. Sci. Instrum. 81, 10D314 (2010)] for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27862905/intranasal-fentanyl-for-initial-treatment-of-vaso-occlusive-crisis-in-sickle-cell-disease
#9
Daniel M Fein, Jeffrey R Avner, Kathryn Scharbach, Deepa Manwani, Hnin Khine
BACKGROUND: Analgesia administration for children with vaso-occlusive crises is often delayed in the emergency department. Intranasal fentanyl (INF) has been shown to be safe and effective in providing rapid analgesia for other painful conditions. Our objective was to determine if children with a vaso-occlusive crisis (VOC) who received initial treatment with INF compared to placebo achieved a greater decrease in pain score after 20 min. PROCEDURE: This was a randomized, double-blind, placebo-controlled trial...
November 10, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27832140/the-effects-of-compensatory-auditory-stimulation-and-high-definition-transcranial-direct-current-stimulation-hd-tdcs-on-tinnitus-perception-a-randomized-pilot-study
#10
Simon Henin, Dovid Fein, Eric Smouha, Lucas C Parra
BACKGROUND: Tinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound. OBJECTIVE: The purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the tinnitus percept acutely using customized auditory stimulation. To further enhance the effects of auditory stimulation, this intervention was paired with high-definition transcranial direct current stimulation (HD-tDCS)...
2016: PloS One
https://www.readbyqxmd.com/read/27798263/cancer-cells-induce-metastasis-supporting-neutrophil-extracellular-dna-traps
#11
Juwon Park, Robert W Wysocki, Zohreh Amoozgar, Laura Maiorino, Miriam R Fein, Julie Jorns, Anne F Schott, Yumi Kinugasa-Katayama, Youngseok Lee, Nam Hee Won, Elizabeth S Nakasone, Stephen A Hearn, Victoria Küttner, Jing Qiu, Ana S Almeida, Naiara Perurena, Kai Kessenbrock, Michael S Goldberg, Mikala Egeblad
Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular traps (NETs). These are pathogen-trapping structures generated by expulsion of the neutrophil's DNA with associated proteolytic enzymes. NETs produced by infection can promote cancer metastasis. We show that metastatic breast cancer cells can induce neutrophils to form metastasis-supporting NETs in the absence of infection. Using intravital imaging, we observed NET-like structures around metastatic 4T1 cancer cells that had reached the lungs of mice...
October 19, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27782813/additive-value-of-pre-operative-and-one-month-post-operative-lymphocyte-count-for-death-risk-stratification-in-patients-with-resectable-pancreatic-cancer-a-multicentric-study
#12
Christelle d'Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb, Philippe Bachellier, Christophe Borg
BACKGROUND: Pancreatic adenocarcinoma (PDAC) incidence is increasing worldwide. Several studies have shown that lymphopenia was correlated with a poor prognosis but the potential interest to measure lymphopenia in the pre and post-operative setting as well as its added value among conventional prognostic factors was never investigated. METHODS: Data from two independent cohorts in whom patients underwent resection for pancreatic carcinoma were retrospectively recorded...
October 26, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27743321/factor-analysis-of-the-childhood-autism-rating-scale-in-a-sample-of-two-year-olds-with-an-autism-spectrum-disorder
#13
Emily Moulton, Kathryn Bradbury, Marianne Barton, Deborah Fein
The Childhood Autism Rating Scale (CARS), (Schopler et al. in J Autism Dev Disord 10(1):91-103, 1980) is a 15-item observation-based rating scale that yields a total score reflective of autism symptom severity. This study investigated the factor structure of the CARS in a sample of 2-year-old children with DSM-IV-TR (American Psychiatric Association in Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Publishing, Washington, 2000) diagnoses of AD or PDD-NOS. Following a preliminary internal cross-validation, principal axis factor analysis was completed (N = 282)...
October 14, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27741067/are-graduating-pediatric-residents-prepared-to-perform-infant-lumbar-punctures-a-multi-institutional-descriptive-study
#14
Marc A Auerbach, Marjorie Lee White, Sweta Bhargava, Pavan Zaveri, Elizabeth B Seelbach, Rebekah A Burns, Renuka Mehta, Brett McAninch, Daniel Fein, Todd P Chang, David O Kessler
OBJECTIVES: Few published studies describe graduating pediatric residents' procedural skills or success rates. This information would help guide supervisors' decisions about graduating residents' preparedness, training, and supervision needs. This study aimed to measure success rates for graduating pediatric residents performing infant lumbar puncture (LP) during the final months of their training and to describe their experiences performing and supervising infant LPs during the course of their training...
October 6, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27705180/preschool-predictors-of-school-age-academic-achievement-in-autism-spectrum-disorder
#15
Lauren E Miller, Jeffrey D Burke, Eva Troyb, Kelley Knoch, Lauren E Herlihy, Deborah A Fein
OBJECTIVE: Characterization of academic functioning in children with autism spectrum disorder (ASD), particularly predictors of achievement, may have important implications for intervention. The current study aimed to characterize achievement profiles, confirm associations between academic ability and concurrent intellectual and social skills, and explore preschool predictors of school-age academic achievement in a sample of children with ASD. METHOD: Children with ASD (n = 26) were evaluated at the approximate ages of two, four, and ten...
February 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27696583/yield-and-complications-of-kidney-biopsies-over-two-decades-in-a-tertiary-pediatric-center
#16
Roei Hod Feins, Anna Tobar, Miriam Davidovits
BACKGROUND: Kidney biopsy serves as an adjunct for the diagnosis of renal disease. However, it is not always productive. This study evaluated the yield and risks of kidney biopsies performed in 1995-2014 at a tertiary pediatric medical center. METHODS: The medical files of all patients who underwent closed percutaneous biopsy for various indications in native or transplanted kidneys were retrospectively reviewed for patient characteristics, technical and histopathologic findings, biopsy yield, and biopsy complications...
October 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27676519/p1-33-afatinib-versus-chemotherapy-for-egfr%C3%A2-mutation-positive-nsclc-patients%C3%A2-aged-%C3%A2-65-years-subgroup-analysis-of-lux-lung-3-6-track-advanced-nsclc
#17
Luis Fein, Yi-Long Wu, Lecia V Sequist, Sarayut L Geater, Sergey Orlov, Ki Hyeong Lee, Chun-Ming Tsai, Terufumi Kato, Katsuyuki Kiura, Carlos H Barrios, Martin Schuler, Vera Hirsh, Nobuyuki Yamamoto, Kenneth O'Byrne, Tony Mok, Dan Massey, Angela Märten, James Chih-Hsin Yang
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27668921/script-concordance-testing-to-determine-infant-lumbar-puncture-practice-variation
#18
Nnenna Ogochukwu Chime, Martin V Pusic, Marc Auerbach, Renuka Mehta, Daniel J Scherzer, Wendy Van Ittersum, Brett McAninch, Daniel M Fein, Elizabeth Seelbach, Pavan Zaveri, Jennifer M Jackson, David Kessler, Todd P Chang
OBJECTIVES: Script concordance testing (SCT) is used to assess clinical decision-making. We explore the use of SCT to (1) quantify practice variations in infant lumbar puncture (LP) and (2) analyze physician's characteristics affecting LP decision making. METHODS: Using standard SCT processes, a panel of pediatric subspecialty physicians constructed 15 infant LP case vignettes, each with 2 to 4 SCT questions (a total of 47). The vignettes were distributed to pediatric attending physicians and fellows at 10 hospitals within the INSPIRE Network...
September 23, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27660932/systemic-lupus-erythematosus-does-not-increase-risk-of-adverse-events-in-the-first-6-months-after-total-knee-arthroplasty
#19
Arielle W Fein, Caroline A Figgie, Taylor R Dodds, Joshua Wright-Chisem, Michael L Parks, Lisa A Mandl, Edwin P Su, Jane E Salmon, David J Mayman, Yuo-Yu Lee, Mark P Figgie, Susan M Goodman
BACKGROUND: Increasing numbers of patients with systemic lupus erythematosus (SLE) are undergoing total knee arthroplasty (TKA). Whether postsurgical adverse events (AEs) are higher in patients with SLE than patients with osteoarthritis (OA) is unknown. OBJECTIVES: This study aims to compare AEs within 6 months of TKA. METHODS: Patients in a single institution's arthroplasty and SLE registries who underwent TKA from 2007 to 2014 were eligible...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27628939/cognitive-and-adaptive-skills-in-toddlers-who-meet-criteria-for-autism-in-dsm-iv-but-not-dsm-5
#20
Dasal Tenzin Jashar, Laura A Brennan, Marianne L Barton, Deborah Fein
The current study compared adaptive and cognitive skills, and autism severity of toddlers with an autism spectrum disorder (ASD) diagnosis under DSM-IV but not DSM-5 criteria (DSM-IV only group) to those who met autism criteria under both diagnostic systems (DSM-5 group) and to those without ASD (non-ASD group). The toddlers in the DSM-IV only group were less delayed on various domains of adaptive (Communication, Socialization) and cognitive (Expressive and Receptive language, Fine Motor, Visual Reception) skills, and had less severe symptoms of ASD than the DSM-5 group...
December 2016: Journal of Autism and Developmental Disorders
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