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https://www.readbyqxmd.com/read/28526371/the-psychosocial-needs-of-adolescent-males-following-interpersonal-assault
#1
Rachel K Myers, Laura Vega, Alison J Culyba, Joel A Fein
PURPOSE: We examined the self-identified, postassault psychosocial needs of male adolescents to guide recovery and healing after being seen in an emergency department (ED) for a violence-related injury. METHODS: We analyzed deidentified data from 49 adolescent male adolescents who participated in a postdischarge case management program following a violence-related injury. Descriptive statistics summarized youths' demographic characteristics and self-identified needs and goals for postassault recovery...
May 8, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28525773/acetone-facilitated-dna-sampling-from-electrical-tapes-improves-dna-recovery-and-enables-latent-fingerprints-development
#2
Ilan Feine, Moshe Shpitzen, Boris Geller, Eran Salmon, Tsach Peleg, Jonathan Roth, Ron Gafny
Electrical tapes (ETs) are a common component of improvised explosive devices (IEDs) used by terrorists or criminal organizations and represent a valuable forensic resource for DNA and latent fingerprints recovery. However, DNA recovery rates are typically low and usually below the minimal amount required for amplification. In addition, most DNA extraction methods are destructive and do not allow further latent fingerprints development. In the present study a cell culture based touch DNA model was used to demonstrate a two-step acetone-water DNA recovery protocol from ETs...
May 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28480335/toward-transoral-peripheral-lung-access-combining-continuum-robots-and-steerable-needles
#3
Philip J Swaney, Arthur W Mahoney, Bryan I Hartley, Andria A Remirez, Erik Lamers, Richard H Feins, Ron Alterovitz, Robert J Webster
Lung cancer is the most deadly form of cancer in part because of the challenges associated with accessing nodules for diagnosis and therapy. Transoral access is preferred to percutaneous access since it has a lower risk of lung collapse, yet many sites are currently unreachable transorally due to limitations with current bronchoscopic instruments. Toward this end, we present a new robotic system for image-guided trans-bronchoscopic lung access. The system uses a bronchoscope to navigate in the airway and bronchial tubes to a site near the desired target, a concentric tube robot to move through the bronchial wall and aim at the target, and a bevel-tip steerable needle with magnetic tracking to maneuver through lung tissue to the target under closed-loop control...
March 2017: J Med Robot Res
https://www.readbyqxmd.com/read/28476133/improving-practice-guidelines-for-the-treatment-of-denture-related-erythematous-stomatitis-a-study-protocol-for-a-randomized-controlled-trial
#4
Raphael F de Souza, Muhammad Faheem Khiyani, Carolina A L Chaves, Jocelyne Feine, Jean Barbeau, Ramón Fuentes, Eduardo Borie, Luciana C Crizostomo, Claudia H Silva-Lovato, Pierre Rompre, Elham Emami
BACKGROUND: Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health professionals, based on the belief that colonization by Candida spp. is the main cause of DES. However, high recurrence rates and adverse effects are commonly observed, prompting the need for practice guidelines regarding treatment. Results from our pilot study demonstrate that palatal brushing can reduce the palatal inflammation and potentially associated Candida carriage without any need for antifungal therapy...
May 5, 2017: Trials
https://www.readbyqxmd.com/read/28463856/multiple-pulmonary-nodules-in-malignancy
#5
Apurwa Karki, Rakesh Shah, Alan Fein
PURPOSE OF REVIEW: Multiple pulmonary nodules are a common finding especially with the implementation of lung cancer screening. Available guidelines address the management of solitary pulmonary nodules. The management of the multiple pulmonary nodules would differ based on the characteristic of the nodules, their distribution, and the history of the patients as well. RECENT FINDINGS: Most of the recent publications on multiple pulmonary nodules consist of individual case reports or case series...
May 1, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28462508/osseointegration-of-standard-and-mini-dental-implants-a-histomorphometric-comparison
#6
Jagjit S Dhaliwal, Rubens F Albuquerque, Monzur Murshed, Jocelyne S Feine
BACKGROUND: Mini dental implants (MDIs) are becoming increasingly popular for rehabilitation of edentulous patients because of their several advantages. However, there is a lack of evidence on the osseointegration potential of the MDIs. The objective of the study was to histomorphometrically evaluate and compare bone apposition on the surface of MDIs and standard implants in a rabbit model. METHODS: Nine New Zealand white rabbits were used for the study to meet statistical criteria for adequate power...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28455168/atrp-grown-protein-polymer-conjugates-containing-phenylpiperazine-selectively-enhance-transepithelial-protein-transport
#7
Chad S Cummings, Katherine Fein, Hironobu Murata, Rebecca L Ball, Alan J Russell, Kathryn A Whitehead
Despite its patient-friendliness, the oral route is not yet a viable strategy for the delivery of biomacromolecular therapeutics. This is, in part, due to the large size of proteins, which greatly limits their absorption across the intestinal epithelium. Although chemical permeation enhancers can improve macromolecular transport, their positive impact is often accompanied by toxicity. One element potentially contributing to this toxicity is the lack of co-localization of the enhancer with the protein drug, which can result in non-specific permeation of the intestine as well as enhancer overdosing in some areas due to non-uniform distribution...
April 25, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28423460/individual-and-neighborhood-characteristics-of-children-seeking-emergency-department-care-for-firearm-injuries-within-the-pecarn-network
#8
Patrick M Carter, Lawrence J Cook, Michelle L Macy, Mark R Zonfrillo, Rachel M Stanley, James M Chamberlain, Joel A Fein, Elizabeth R Alpern, Rebecca Cunningham
OBJECTIVE: To describe the characteristics of children seeking emergency care for firearm injuries within the PECARN network, and assess the influence of both individual and neighborhood factors on firearm-related injury risk. METHODS: This was a retrospective, multicenter cross-sectional analysis of children (<19-years-old) presenting to 16 pediatric EDs (2004-2008). ICD-9-CM E-codes were used to identify and categorize firearm injuries by mechanism/intent. Neighborhood variables were derived from home address data...
April 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28422558/understanding-transgender-men-s-experiences-with-and-preferences-for-cervical-cancer-screening-a-rapid-assessment-survey
#9
Julia Seay, Atticus Ranck, Roy Weiss, Christopher Salgado, Lydia Fein, Erin Kobetz
PURPOSE: Transgender men are less likely than cisgender women to receive cervical cancer screening. The purpose of the current study was to understand experiences with and preferences for cervical cancer screening among transgender men. METHODS: Ninety-one transgender men ages 21-63 completed the survey. The survey evaluated experiences with and preferences for screening, including opinions regarding human papillomavirus (HPV) self-sampling as a primary cervical cancer screening...
April 19, 2017: LGBT Health
https://www.readbyqxmd.com/read/28383673/overall-survival-prediction-and-usefulness-of-second-line-chemotherapy-in-advanced-pancreatic-adenocarcinoma
#10
Angélique Vienot, Guillaume Beinse, Christophe Louvet, Louis de Mestier, Aurélia Meurisse, Francine Fein, Bruno Heyd, Denis Cleau, Christelle d'Engremont, Anne-Claire Dupont-Gossart, Zaher Lakkis, Christophe Tournigand, Olivier Bouché, Benoît Rousseau, Cindy Neuzillet, Franck Bonnetain, Christophe Borg, Dewi Vernerey
Background: In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line chemotherapy (L2). Better discrimination of overall survival (OS) may help clinical decision-making. We aimed to predict OS from the beginning of L2 and to assess the benefit from chemotherapy among the identified risk groups. Methods: Analyses were derived from all consecutive aPDAC patients treated at Besancon University Hospital, Besancon, France, between January 2003 and December 2013 (n = 462)...
April 4, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28374339/structure-function-analysis-of-phenylpiperazine-derivatives-as-intestinal-permeation-enhancers
#11
Katherine C Fein, Nicholas G Lamson, Kathryn A Whitehead
PURPOSE: A major obstacle preventing oral administration of macromolecular therapeutics is poor absorption across the intestinal epithelium into the bloodstream. One strategy to improve transport across this barrier is the use of chemical permeation enhancers. Several molecular families with permeation enhancing potential have been identified previously, including piperazines. In particular, 1-phenylpiperazine has been shown to enhance transepithelial transport with minimal cytotoxicity compared to similarly effective molecules...
June 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28371941/efficacy-of-mirogabalin-ds-5565-on-patient-reported-pain-and-sleep-interference-in-patients-with-diabetic-neuropathic-pain-secondary-outcomes-of-a-phase-ii-proof-of-concept-study
#12
Domenico Merante, Julio Rosenstock, Uma Sharma, Karen Feins, Ching Hsu, Aaron Vinik
Objective. : To evaluate the effects of mirogabalin on patient-reported pain and sleep interference in diabetic peripheral neuropathic pain (DPNP). Subjects. : Adults (≥18 years) with type 1 or 2 diabetes, glycosylated hemoglobin of 10% or less at screening, and DPNP for six months or more were eligible for participation. Methods.:  Subjects (N = 452) were randomly assigned (2:1:1:1:1:1:1) to receive placebo, dose-ranging mirogabalin (5, 10, 15, 20, 30 mg/day), or pregabalin (300 mg/day) for five weeks...
March 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28346313/population-pharmacokinetics-of-gemcitabine-and-dfdu-in-pancreatic-cancer-patients-using-an-optimal-design-sparse-sampling-approach
#13
Cindy Serdjebi, Florence Gattacceca, Jean-François Seitz, Francine Fein, Johan Gagnière, Eric François, Abakar Abakar-Mahamat, Gael Deplanque, Madani Rachid, Bruno Lacarelle, Joseph Ciccolini, Laetitia Dahan
BACKGROUND: Gemcitabine remains a pillar in pancreatic cancer treatment. However, toxicities are frequently observed. Dose adjustment based on therapeutic drug monitoring might help decrease the occurrence of toxicities. In this context, this work aims at describing the pharmacokinetics (PK) of gemcitabine and its metabolite dFdU in pancreatic cancer patients and at identifying the main sources of their PK variability using a population PK approach, despite a sparse sampled-population and heterogeneous administration and sampling protocols...
June 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28344564/investigating-the-grammatical-and-pragmatic-origins-of-wh-questions-in-children-with-autism-spectrum-disorders
#14
Manya Jyotishi, Deborah Fein, Letitia Naigles
Compared to typically developing children, children with autism (ASD) show delayed production of wh-questions. It is currently controversial the degree to which such deficits derive from social-pragmatic requirements and/or because these are complex grammatical structures. The current study employed the intermodal preferential looking (IPL) paradigm, which reduces social-pragmatic demands. The IPL paradigm can help distinguish these proposals, as successful comprehension promotes the "pragmatics-origins" argument whereas comprehension difficulties would implicate a "grammatical-origins" argument...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28335653/anesthesia-management-of-complete-versus-incomplete-placenta-previa-a-retrospective-cohort-study
#15
Sharon Orbach-Zinger, Carolyn F Weiniger, Amir Aviram, Alexander Balla, S Fein, L A Eidelman, A Ioscovich
PURPOSE: Placenta previa (PP) is a major cause of obstetric hemorrhage. Clinical diagnosis of complete versus incomplete PP has a significant impact on the peripartum outcome. Our study objective is to examine whether distinction between PP classifications effect anesthetic management. METHODS AND MATERIALS: This multi center, retrospective, cohort study was performed in two tertiary university-affiliated medical centers between the years 2005- 2013. Electronic delivery databases were reviewed for demographic, anesthetic, obstetric hemorrhage, and postoperative outcomes for all cases...
March 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28262184/resting-state-synchrony-in-long-term-abstinent-alcoholics-effects-of-a-current-major-depressive-disorder-diagnosis
#16
George Fein, Jazmin Camchong, Valerie A Cardenas, Andy Stenger
Alcoholism is characterized by a lack of control over an impulsive and compulsive drive toward excessive alcohol consumption despite significant negative consequences; our previous work demonstrated that successful abstinence is characterized by decreased resting-state synchrony (RSS) as measured with functional magnetic resonance imaging (fMRI), within appetitive drive networks and increased RSS in emotion regulation and inhibitory executive control networks. Our hypothesis is that LTAA (Long-Term Abstinent Alcoholics) with a current major depressive disorder (MDD) drank primarily to deal with the negative affect associated with their MDD and not because of a heightened externalizing diathesis (including heightened appetitive drive), and consequently, in achieving and maintaining abstinence, such individuals would not exhibit the RSS adaptations characteristic of pure alcoholics...
March 2017: Alcohol
https://www.readbyqxmd.com/read/28259313/limited-evidence-suggests-tooth-loss-is-associated-with-increased-risk-of-cognitive-impairment
#17
Elizabeth Krall Kaye
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Tooth loss increases the risk of diminished cognitive function: a systematic review and meta-analysis. Cerutti-Kopplin D, Feine J, Padilha DM, et al. JDR Clin Translational Res 2016;1(1):10-9. SOURCE OF FUNDING: Government. Dr Cerutti-Kopplin received a scholarship for the Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior, Brazil; Dr Booij received a new investigator award from the Canadian Institutes of Health Research; and Dr Emami holds a Canadian Institutes of Health Research Clinician Science Award and new investigator funds from the Fonds de Recherche du Québec-Santé TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data...
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28252468/application-of-a-framework-to-implement-trauma-informed-care-throughout-a-pediatric-health-care-network
#18
Danielle Weiss, Nancy Kassam-Adams, Carol Murray, Kristen L Kohser, Joel A Fein, Flaura K Winston, Meghan L Marsac
INTRODUCTION: To evaluate the initial application of a recently published three-step framework for implementing trauma-informed care (TIC) in a pediatric health care network by applying Framework for Spread. METHODS: In steps 1 and 2 of the framework, we established commitment from the health care network leadership and initial interest in TIC among clinical providers (step 1), set evidence-based training goals and created the associated TIC training content (step 2)...
January 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28251146/exploring-complexity-of-deliberate-self-poisoning-through-network-analysis
#19
Leila R Kalankesh, Mostafa Farahbakhsh, Rebecca A Fein, Nazila Moftian, Zahra Nasiry
The purpose of this research was to examine the complexity of circumstances that result in deliberate self-poisoning cases. For the purposes of this paper, the cases were patients that presented for care and were admitted to the specialty hospital in Northwest of Iran. The research examined the problems preceding deliberate self-poisoning and the interrelations among them by applying network analysis methods. The network was scored for degrees of centrality and betweenness centrality. Structural analysis of network also was conducted using block modelling...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/28181279/validation-of-the-acute-leukemia-ebmt-score-for-prediction-of-mortality-following-allogeneic-stem-cell-transplantation-in-a-multi-center-gitmo-cohort
#20
Roni Shouval, Francesca Bonifazi, Joshua Fein, Cristina Boschini, Elena Oldani, Myriam Labopin, Roberto Raimondi, Nicoletta Sacchi, Osamah Dabash, Ron Unger, Mohamad Mohty, Alessandro Rambaldi, Arnon Nagler
Predictive models may help in determining the risk/benefit ratio of allogeneic hematopoietic stem cell transplantation (HSCT) in acute leukemia (AL). Using a machine-learning algorithm we have previously developed the AL- European Society for Blood and Marrow Transplantation (EBMT) score for prediction of mortality following transplantation. We report here the first external validation of the AL-EBMT score in a cohort of AL patients from the Italian national transplantation network. A total of 1848 patients transplanted between the years 2000-2014 were analyzed...
May 2017: American Journal of Hematology
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