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https://www.readbyqxmd.com/read/28797781/prognostic-scoring-systems-in-allogeneic-hematopoietic-stem-cell-transplantation-where-do-we-stand
#1
REVIEW
Rashmika Potdar, Gabor Varadi, Joshua Fein, Myriam Labopin, Arnon Nagler, Roni Shouval
Allogeneic hematopoietic stem cell transplantation is a potentially curative treatment for many hematologic disorders. Maximizing the benefit of transplantation for disease control while minimizing the risk for associated complications remains the field's leading challenge. This has prompted the development of multiple prognostic scoring systems over the last two decades. Prognostic scores can be used for informed decision making, better patient counseling, design of interventional trials and analysis of prospective and retrospective data...
August 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28797187/a-survey-of-physicians-attitudes-toward-uterotonic-administration-in-parturients-undergoing-cesarean-section
#2
Sharon Orbach-Zinger, Sharon Einav, Assaf Yonah, Leonid A Eidelman, Shia Fein, Atara Davis Ba, Alexander Ioscovich
OBJECTIVE: Oxytocin is globally accepted as first line treatment for prevention of post partum hemorrhage. However there is wide variability in its use in clinical practice. In this study we aimed to evaluate obstetricians and anesthesiologists attitudes towards uterotonic practices in Israel. STUDY DESIGN: The current survey was designed to study the preferences of obstetricians and anesthesiologists in seven University hospitals regarding the type, dose and mode of administration of uterotonic drugs, as well as their knowledge regarding the side effects of these drugs...
August 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28777649/clinical-value-of-mammography-in-the-evaluation-of-palpable-breast-lumps-in-women-30-years-old-and-older
#3
Ann L Brown, Jordana Phillips, Priscilla J Slanetz, Valerie Fein-Zachary, Shambhavi Venkataraman, Vandana Dialani, Tejas S Mehta
OBJECTIVE: The purpose of this study was to determine whether mammography adds clinical value in the diagnostic imaging workup of women 30 years old and older who present with palpable breast lumps. MATERIALS AND METHODS: We retrospectively identified the records of all women 30 years old and older who underwent imaging evaluation with mammography and ultrasound for a palpable lump between January 1, 2009, and December 31, 2010. Imaging reports were reviewed for findings related to the lump and for incidental nonpalpable findings...
August 4, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28754820/an-integrative-scoring-system-for-survival-prediction-following-umbilical-cord-blood-transplantation-in-acute-leukemia
#4
Roni Shouval, Annalisa Ruggeri, Myriam Labopin, Mohamad Mohty, Guillermo Sanz, Gérard Michel, Jurgen Kuball, Patrice Chevallier, Amal Al-Seraihy, Noel-Jean Milpied, Cristina Díaz Heredia, William Arcese, Didier Blaise, Vanderson Rocha, Joshua Fein, Ron Unger, Frederic Baron, Bader Peter, Eliane Gluckman, Arnon Nagler
Purpose: Survival of acute leukemia (AL) patients following umbilical cord blood transplantation (UCBT) is dependent on an array of individual features. Integrative models for risk assessment are lacking. We sought to develop a scoring system for prediction of overall survival (OS) and leukemia-free survival (LFS) at 2-years following UCBT in AL patients. <p>Experimental design: The study cohort included 3,140 pediatric and adult AL UCBT patients from the European Society of Blood and Marrow Transplantation and Eurocord registries...
July 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28734441/a-novel-and-successful-repair-of-a-left-atriogastric-fistula-after-esophagectomy
#5
Nikhil Panda, Eric N Feins, Andrea Axtell, Natalie Lui, Serguei I Melnitchouk, Dean M Donahue
Atriogastric fistulas remain a rare adverse event in patients who undergo esophagectomy with gastric pullthrough. The presentation of an atriogastric fistula ranges from self-limited gastrointestinal bleeding to life-threatening hemorrhage, end-organ dysfunction from septic emboli, or both. These fistulas are associated with significant mortality. Previous reports describe successful repairs of gastrocardiac fistulas with the use of cardiopulmonary bypass. This report describes a patient with a significant burden of cerebral embolic disease, which therefore required a unique approach to fistula repair...
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28722400/experimental-measurements-and-surface-complexation-modeling-of-u-vi-adsorption-onto-multilayered-graphene-oxide-the-importance-of-adsorbate-adsorbent-ratios
#6
Thomas A Duster, Jennifer E S Szymanowski, Jeremy B Fein
Surface complexation models use experimental adsorption measurements to calculate stability constants that quantify the thermodynamic stability of adsorbed species. However, these constants are often poorly constrained due to nearly complete removal of the solute from solution and/or because the tested adsorbate:adsorbent ratios are not varied sufficiently. Using data sets that quantify the adsorption of U(VI) to multilayered graphene oxide (MLGO), we tested whether three different U(VI):MLGO ratios (3 ppm U; 20-210 mg L(-1) MLGO) affect the ability of nonelectrostatic and diffuse layer models to predict U(VI) adsorption behaviors across a range of ionic strength (1-100 mM) and pH (2-9...
July 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28709680/patient-satisfaction-with-laser-sintered-removable-partial-dentures-a-crossover-pilot-clinical-trial
#7
Balqees Almufleh, Elham Emami, Omar Alageel, Fabiana de Melo, Francois Seng, Eric Caron, Samer Abi Nader, Ashwaq Al-Hashedi, Rubens Albuquerque, Jocelyne Feine, Faleh Tamimi
STATEMENT OF PROBLEM: Clinical data regarding newly introduced laser-sintered removable partial dentures (RPDs) are needed before this technique can be recommended. Currently, only a few clinical reports have been published, with no clinical studies. PURPOSE: This clinical trial compared short-term satisfaction in patients wearing RPDs fabricated with conventional or computer-aided design and computer-aided manufacturing (CAD-CAM) laser-sintering technology. MATERIAL AND METHODS: Twelve participants with partial edentulism were enrolled in this pilot crossover double-blinded clinical trial...
July 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28689003/primary-amyloidosis-with-renal-involvement-outcomes-in-77-consecutive-patients-at-a-single-center
#8
Sandy W Wong, Denis Toskic, Melissa Warner, Cindy Varga, Alejandro Moreno-Koehler, Daniel Fein, Teresa Fogaren, Lisa Lee, Colin M Oliver, Spencer D Guthrie, Raymond L Comenzo
BACKGROUND: Outcomes in primary amyloid renal patients are of interest as the era of monoclonal antibody therapies begins. PATIENTS AND METHODS: We studied 77 consecutive primary amyloid renal patients (58% men) for renal progression (end stage renal disease [ESRD]), renal response (RR), and overall survival (OS). RESULTS: At diagnosis median age was 63 (range, 35-81) years, estimated glomerular filtration rate 70 mL/min (range, 5-114), difference between involved and uninvolved free light chains 127 mg/L (range, 1-9957), ESRD 4%, renal stage 2 and 3 78%, and cardiac stage 2 and 3 56%...
June 17, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28660592/erratum-to-osseointegration-of-standard-and-mini-dental-implants-a-histomorphometric-comparison
#9
Jagjit S Dhaliwal, Rubens F Albuquerque, Monzur Murshed, Jocelyne S Feine
No abstract text is available yet for this article.
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28656566/in-vitro-comparison-of-two-titanium-dental-implant-surface-treatments-3m%C3%A2-espe%C3%A2-mdis-versus-ankylos%C3%A2
#10
Jagjit Singh Dhaliwal, Juliana Marulanda, Jingjing Li, Sharifa Alebrahim, Jocelyne Sheila Feine, Monzur Murshed
BACKGROUND: An ideal implant should have a surface that is conducive to osseointegration. In vitro cell culture studies using disks made of same materials and surface as of implants may provide useful information on the events occurring at the implant-tissue interface. In the current study, we tested the hypothesis that there is no difference in the proliferation and differentiation capacities of osteoblastic cells when cultured on titanium disks mimicking the surface of 3M™ESPE™ MDIs or standard (Ankylos®) implants...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28647722/developing-implementation-strategies-for-firearm-safety-promotion-in-paediatric-primary-care-for-suicide-prevention-in-two-large-us-health-systems-a-study-protocol-for-a-mixed-methods-implementation-study
#11
Courtney Benjamin Wolk, Shari Jager-Hyman, Steven C Marcus, Brian K Ahmedani, John E Zeber, Joel A Fein, Gregory K Brown, Adina Lieberman, Rinad S Beidas
INTRODUCTION: The promotion of safe firearm practices, or firearms means restriction, is a promising but infrequently used suicide prevention strategy in the USA. Safety Check is an evidence-based practice for improving parental firearm safety behaviour in paediatric primary care. However, providers rarely discuss firearm safety during visits, suggesting the need to better understand barriers and facilitators to promoting this approach. This study, Adolescent Suicide Prevention In Routine clinical Encounters, aims to engender a better understanding of how to implement the three firearm components of Safety Check as a suicide prevention strategy in paediatric primary care...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28603975/controls-on-bacterial-cell-envelope-sulfhydryl-site-concentrations-the-effect-of-glucose-concentration-during-growth
#12
Qiang Yu, Jeremy B Fein
Bacterial sulfhydryl sites can form strong complexes with chalcophilic metals such as Hg and Cd, thereby affecting the fate, transport, and bioavailability of these metals in both natural and engineered systems. In this study, five bacterial species were cultured in M9 minimal media containing a range of glucose concentrations as carbon source and in a high-nutrient TSB medium enriched with 50 g/L of glucose, and the sulfhydryl site concentrations of the obtained biomass samples were determined through selective sulfhydryl site-blocking, potentiometric titrations, and surface complexation modeling...
June 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28578607/abiraterone-plus-prednisone-in-metastatic-castration-sensitive-prostate-cancer
#13
RANDOMIZED CONTROLLED TRIAL
Karim Fizazi, NamPhuong Tran, Luis Fein, Nobuaki Matsubara, Alfredo Rodriguez-Antolin, Boris Y Alekseev, Mustafa Özgüroğlu, Dingwei Ye, Susan Feyerabend, Andrew Protheroe, Peter De Porre, Thian Kheoh, Youn C Park, Mary B Todd, Kim N Chi
BACKGROUND: Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer. METHODS: In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 1199 patients to receive either androgen-deprivation therapy plus abiraterone acetate (1000 mg daily, given once daily as four 250-mg tablets) plus prednisone (5 mg daily) (the abiraterone group) or androgen-deprivation therapy plus dual placebos (the placebo group)...
July 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28576778/what-the-snp-plaid-cymru-the-dup-and-sinn-fein-are-promising-the-nhs
#14
Andy Cowper
No abstract text is available yet for this article.
June 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28569625/sexual-preferences-and-partnerships-of-transgender-persons-mid-or-post-transition
#15
Lydia A Fein, Christopher J Salgado, Klara Sputova, Christopher M Estes, Carlos A Medina
The process of gender transition has varying effects on various aspects of sexuality. The purpose of this study was to investigate the effects of transitioning on transgender persons' sexual preferences and partnerships. Data were collected through an anonymous online survey. Questions focused on timing of gender transition in relation to change in sexual preference. Transgender individuals have a variety of sexual partners, predominantly cisgender, and may change sexual preference when they transition. Transitioning can be associated with having no primary sexual partner, despite past sexual partnerships...
June 1, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28537752/imaging-features-of-spindle-cell-breast-lesions
#16
REVIEW
Andrew S Taliaferro, Valerie Fein-Zachary, Shambhavi Venkataraman, Tejas S Mehta, Amee Patel, Priscilla J Slanetz
OBJECTIVE: The purpose of our study is to review the clinical presentation, multimodality appearance, and management of the most common benign and malignant spindle cell lesions of the breast. CONCLUSION: Spindle cell lesions of the breast exhibit characteristic features at mammography, ultrasound, and MRI. Although a definitive diagnosis of these lesions cannot be made with diagnostic imaging alone, knowledge of their characteristic imaging features can assist in refining the differential diagnosis and guiding appropriate management...
August 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28526371/the-psychosocial-needs-of-adolescent-males-following-interpersonal-assault
#17
Rachel K Myers, Laura Vega, Alison J Culyba, Joel A Fein
PURPOSE: We examined the self-identified, postassault psychosocial needs of male adolescents to guide recovery and healing after being seen in an emergency department (ED) for a violence-related injury. METHODS: We analyzed deidentified data from 49 adolescent male adolescents who participated in a postdischarge case management program following a violence-related injury. Descriptive statistics summarized youths' demographic characteristics and self-identified needs and goals for postassault recovery...
August 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28525773/acetone-facilitated-dna-sampling-from-electrical-tapes-improves-dna-recovery-and-enables-latent-fingerprints-development
#18
Ilan Feine, Moshe Shpitzen, Boris Geller, Eran Salmon, Tsach Peleg, Jonathan Roth, Ron Gafny
Electrical tapes (ETs) are a common component of improvised explosive devices (IEDs) used by terrorists or criminal organizations and represent a valuable forensic resource for DNA and latent fingerprints recovery. However, DNA recovery rates are typically low and usually below the minimal amount required for amplification. In addition, most DNA extraction methods are destructive and do not allow further latent fingerprints development. In the present study a cell culture based touch DNA model was used to demonstrate a two-step acetone-water DNA recovery protocol from ETs...
May 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28480335/toward-transoral-peripheral-lung-access-combining-continuum-robots-and-steerable-needles
#19
Philip J Swaney, Arthur W Mahoney, Bryan I Hartley, Andria A Remirez, Erik Lamers, Richard H Feins, Ron Alterovitz, Robert J Webster
Lung cancer is the most deadly form of cancer in part because of the challenges associated with accessing nodules for diagnosis and therapy. Transoral access is preferred to percutaneous access since it has a lower risk of lung collapse, yet many sites are currently unreachable transorally due to limitations with current bronchoscopic instruments. Toward this end, we present a new robotic system for image-guided trans-bronchoscopic lung access. The system uses a bronchoscope to navigate in the airway and bronchial tubes to a site near the desired target, a concentric tube robot to move through the bronchial wall and aim at the target, and a bevel-tip steerable needle with magnetic tracking to maneuver through lung tissue to the target under closed-loop control...
March 2017: Journal of medical robotics research
https://www.readbyqxmd.com/read/28476133/improving-practice-guidelines-for-the-treatment-of-denture-related-erythematous-stomatitis-a-study-protocol-for-a-randomized-controlled-trial
#20
Raphael F de Souza, Muhammad Faheem Khiyani, Carolina A L Chaves, Jocelyne Feine, Jean Barbeau, Ramón Fuentes, Eduardo Borie, Luciana C Crizostomo, Claudia H Silva-Lovato, Pierre Rompre, Elham Emami
BACKGROUND: Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health professionals, based on the belief that colonization by Candida spp. is the main cause of DES. However, high recurrence rates and adverse effects are commonly observed, prompting the need for practice guidelines regarding treatment. Results from our pilot study demonstrate that palatal brushing can reduce the palatal inflammation and potentially associated Candida carriage without any need for antifungal therapy...
May 5, 2017: Trials
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