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https://www.readbyqxmd.com/read/28262184/resting-state-synchrony-in-long-term-abstinent-alcoholics-effects-of-a-current-major-depressive-disorder-diagnosis
#1
George Fein, Jazmin Camchong, Valerie A Cardenas, Andy Stenger
Alcoholism is characterized by a lack of control over an impulsive and compulsive drive toward excessive alcohol consumption despite significant negative consequences; our previous work demonstrated that successful abstinence is characterized by decreased resting-state synchrony (RSS) as measured with functional magnetic resonance imaging (fMRI), within appetitive drive networks and increased RSS in emotion regulation and inhibitory executive control networks. Our hypothesis is that LTAA (Long-Term Abstinent Alcoholics) with a current major depressive disorder (MDD) drank primarily to deal with the negative affect associated with their MDD and not because of a heightened externalizing diathesis (including heightened appetitive drive), and consequently, in achieving and maintaining abstinence, such individuals would not exhibit the RSS adaptations characteristic of pure alcoholics...
March 2017: Alcohol
https://www.readbyqxmd.com/read/28259313/limited-evidence-suggests-tooth-loss-is-associated-with-increased-risk-of-cognitive-impairment
#2
Elizabeth Krall Kaye
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Tooth loss increases the risk of diminished cognitive function: a systematic review and meta-analysis. Cerutti-Kopplin D, Feine J, Padilha DM, et al. JDR Clin Translational Res 2016;1(1):10-9. SOURCE OF FUNDING: Government. Dr Cerutti-Kopplin received a scholarship for the Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior, Brazil; Dr Booij received a new investigator award from the Canadian Institutes of Health Research; and Dr Emami holds a Canadian Institutes of Health Research Clinician Science Award and new investigator funds from the Fonds de Recherche du Québec-Santé TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data...
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28252468/application-of-a-framework-to-implement-trauma-informed-care-throughout-a-pediatric-health-care-network
#3
Danielle Weiss, Nancy Kassam-Adams, Carol Murray, Kristen L Kohser, Joel A Fein, Flaura K Winston, Meghan L Marsac
INTRODUCTION: To evaluate the initial application of a recently published three-step framework for implementing trauma-informed care (TIC) in a pediatric health care network by applying Framework for Spread. METHODS: In steps 1 and 2 of the framework, we established commitment from the health care network leadership and initial interest in TIC among clinical providers (step 1), set evidence-based training goals and created the associated TIC training content (step 2)...
January 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28251146/exploring-complexity-of-deliberate-self-poisoning-through-network-analysis
#4
Leila R Kalankesh, Mostafa Farahbakhsh, Rebecca A Fein, Nazila Moftian, Zahra Nasiry
The purpose of this research was to examine the complexity of circumstances that result in deliberate self-poisoning cases. For the purposes of this paper, the cases were patients that presented for care and were admitted to the specialty hospital in Northwest of Iran. The research examined the problems preceding deliberate self-poisoning and the interrelations among them by applying network analysis methods. The network was scored for degrees of centrality and betweenness centrality. Structural analysis of network also was conducted using block modelling...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/28181279/validation-of-the-acute-leukemia-ebmt-score-for-prediction-of-mortality-following-allogeneic-stem-cell-transplantation-in-a-multi-center-gitmo-cohort
#5
Roni Shouval, Francesca Bonifazi, Joshua Fein, Cristina Boschini, Elena Oldani, Myriam Labopin, Roberto Raimondi, Nicoletta Sacchi, Osamah Dabash, Ron Unger, Mohamad Mohty, Alessandro Rambaldi, Arnon Nagler
Predictive models may help in determining the risk/benefit ratio of allogeneic hematopoietic stem cell transplantation (HSCT) in acute leukemia (AL). Using a machine-learning algorithm we have previously developed the AL- European Society for Blood and Marrow Transplantation (EBMT) score for prediction of mortality following transplantation. We report here the first external validation of the AL-EBMT score in a cohort of AL patients from the Italian national transplantation network. A total of 1848 patients transplanted between the years 2000-2014 were analyzed...
February 9, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28150188/customized-smartpeg-for-measurement-of-resonance-frequency-of-mini-dental-implants
#6
Jagjit Singh Dhaliwal, Rubens F Albuquerque, Ali Fakhry, Sukhbir Kaur, Jocelyne S Feine
BACKGROUND: One-piece narrow diameter implants (NDIs) have been recommended as "Single-tooth replacements in the anterior zones, single posterior, multiple-unit fixed dental prosthesis (FDP), edentulous jaws to be rehabilitated with FDP, and edentulous jaws rehabilitation with overdentures in situations with reduced mesiodistal space or reduced ridge width." (ITI consensus 2013). Since NDIs can be immediately loaded, it is important to be able to carry out stability testing. We developed and validated a customized SmartPeg for this type of implant to measure the Implant Stability Quotient (ISQ)...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28121978/a-vibrating-cold-device-to-reduce-pain-in-the-pediatric-emergency-department-a-randomized-clinical-trial
#7
Debra Ann Potts, Katherine Finn Davis, Okan U Elci, Joel A Fein
OBJECTIVE: Pain of intravenous (IV) catheter insertion can be mitigated with appropriate analgesia, thereby avoiding unnecessary distress. Our objective was to compare the self-reported pain of IV catheter insertion in children when using a vibrating cold device (VCD) versus standard of care 4% topical lidocaine cream (TL). METHODS: This was a 2-arm randomized controlled noninferiority trial with a convenience sample of 4- to 18-year-olds requiring nonemergent IV catheter insertion...
January 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28121237/screening-to-identify-groups-of-pediatric-emergency-department-patients-using-latent-class-analysis-of-reported-suicidal-ideation-and-behavior-and-non-suicidal-self-injury
#8
Joanna Herres, Tamar Kodish, Joel Fein, Guy Diamond
Latent class analysis of medical records data from 3,523 emergency department (ED) patients (ages 14-24; 31% Caucasian; 67% female) distinguished six groups with varying histories of suicidal ideation and behavior based on items endorsed on the Behavioral Health Screen, a web based, nurse-initiated screening tool. As expected, the more severe suicidality groups reported higher levels of depressive symptoms, traumatic distress, and substance abuse symptoms. Findings support the validity of the BHS and its utility as a medical decision tool to help ED staff evaluate the severity of patients' suicidality...
January 25, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28107737/contrast-enhanced-spectral-mammography-cesm-versus-mri-in-the-high-risk-screening-setting-patient-preferences-and-attitudes
#9
Jordana Phillips, Matthew M Miller, Tejas S Mehta, Valerie Fein-Zachary, Audrey Nathanson, Wendy Hori, Rita Monahan-Earley, Priscilla J Slanetz
PURPOSE: Our study evaluates patient preferences toward screening CESM versus MRI. MATERIALS AND METHODS: As part of a prospective study, high-risk patients had breast MRI and CESM. Patients completed an anonymous survey to evaluate preferences regarding the two modalities. RESULTS: 88% of participants completed the survey. 79% preferred CESM over MRI if the exams had equal sensitivity. 89% would be comfortable receiving contrast as part of an annual screening test...
March 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28042974/-didn-t-i-just-say-that-comparing-parent-report-and-spontaneous-speech-as-indicators-of-grammatical-development
#10
Manya Jyotishi, Deborah A Fein, Letitia R Naigles
BACKGROUND: The Vineland Adaptive Behavior Scales use parental report to examine communication and social skills in children with typical and atypical development, and exhibit high reliability when compared against overall direct testing. However, findings are mixed comparing Vineland communication/language scores with experimenter-administered tests of language. METHODS: The current study breaks new ground in comparing Vineland reports with direct observation of children's speech by (a) individual items and (b) level of child functioning, focusing on usage of wh-questions, verb tenses, negation, pronouns and noun-verb combinations...
February 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27910560/mitigation-of-hard-x-ray-background-in-backlit-pinhole-imagers
#11
J R Fein, P A Keiter, J P Holloway, S R Klein, J S Davis, R P Drake
Experiments were performed to mitigate the hard x-ray background commonly observed in backlit pinhole imagers. The material of the scaffold holding the primary backlighter foil was varied to reduce the laser-plasma instabilities responsible for hot electrons and resulting hard x-ray background. Radiographic measurements with image plates showed a factor of >25 decrease in x-rays between 30 and 67 keV when going from a plastic to Al or V scaffold. A potential design using V scaffold offers a signal-to-background ratio of 6:1, a factor of 2 greater than using the bare plastic scaffold...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910335/detailed-characterization-of-the-llnl-imaging-proton-spectrometer
#12
A M Rasmus, A U Hazi, M J-E Manuel, C C Kuranz, S R Klein, P X Belancourt, J R Fein, M J MacDonald, R P Drake, B B Pollock, J Park, G J Williams, H Chen
Ultra-intense short pulse lasers incident on solid targets (e.g., thin Au foils) produce well collimated, broad-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields, and density gradients in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built [H. Chen et al., Rev. Sci. Instrum. 81, 10D314 (2010)] for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27862905/intranasal-fentanyl-for-initial-treatment-of-vaso-occlusive-crisis-in-sickle-cell-disease
#13
Daniel M Fein, Jeffrey R Avner, Kathryn Scharbach, Deepa Manwani, Hnin Khine
BACKGROUND: Analgesia administration for children with vaso-occlusive crises is often delayed in the emergency department. Intranasal fentanyl (INF) has been shown to be safe and effective in providing rapid analgesia for other painful conditions. Our objective was to determine if children with a vaso-occlusive crisis (VOC) who received initial treatment with INF compared to placebo achieved a greater decrease in pain score after 20 min. PROCEDURE: This was a randomized, double-blind, placebo-controlled trial...
November 10, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27832140/the-effects-of-compensatory-auditory-stimulation-and-high-definition-transcranial-direct-current-stimulation-hd-tdcs-on-tinnitus-perception-a-randomized-pilot-study
#14
Simon Henin, Dovid Fein, Eric Smouha, Lucas C Parra
BACKGROUND: Tinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound. OBJECTIVE: The purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the tinnitus percept acutely using customized auditory stimulation. To further enhance the effects of auditory stimulation, this intervention was paired with high-definition transcranial direct current stimulation (HD-tDCS)...
2016: PloS One
https://www.readbyqxmd.com/read/27798263/cancer-cells-induce-metastasis-supporting-neutrophil-extracellular-dna-traps
#15
Juwon Park, Robert W Wysocki, Zohreh Amoozgar, Laura Maiorino, Miriam R Fein, Julie Jorns, Anne F Schott, Yumi Kinugasa-Katayama, Youngseok Lee, Nam Hee Won, Elizabeth S Nakasone, Stephen A Hearn, Victoria Küttner, Jing Qiu, Ana S Almeida, Naiara Perurena, Kai Kessenbrock, Michael S Goldberg, Mikala Egeblad
Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular traps (NETs). These are pathogen-trapping structures generated by expulsion of the neutrophil's DNA with associated proteolytic enzymes. NETs produced by infection can promote cancer metastasis. We show that metastatic breast cancer cells can induce neutrophils to form metastasis-supporting NETs in the absence of infection. Using intravital imaging, we observed NET-like structures around metastatic 4T1 cancer cells that had reached the lungs of mice...
October 19, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27782813/additive-value-of-pre-operative-and-one-month-post-operative-lymphocyte-count-for-death-risk-stratification-in-patients-with-resectable-pancreatic-cancer-a-multicentric-study
#16
Christelle d'Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb, Philippe Bachellier, Christophe Borg
BACKGROUND: Pancreatic adenocarcinoma (PDAC) incidence is increasing worldwide. Several studies have shown that lymphopenia was correlated with a poor prognosis but the potential interest to measure lymphopenia in the pre and post-operative setting as well as its added value among conventional prognostic factors was never investigated. METHODS: Data from two independent cohorts in whom patients underwent resection for pancreatic carcinoma were retrospectively recorded...
October 26, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27743321/factor-analysis-of-the-childhood-autism-rating-scale-in-a-sample-of-two-year-olds-with-an-autism-spectrum-disorder
#17
Emily Moulton, Kathryn Bradbury, Marianne Barton, Deborah Fein
The Childhood Autism Rating Scale (CARS), (Schopler et al. in J Autism Dev Disord 10(1):91-103, 1980) is a 15-item observation-based rating scale that yields a total score reflective of autism symptom severity. This study investigated the factor structure of the CARS in a sample of 2-year-old children with DSM-IV-TR (American Psychiatric Association in Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Publishing, Washington, 2000) diagnoses of AD or PDD-NOS. Following a preliminary internal cross-validation, principal axis factor analysis was completed (N = 282)...
October 14, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27741067/are-graduating-pediatric-residents-prepared-to-perform-infant-lumbar-punctures-a-multi-institutional-descriptive-study
#18
Marc A Auerbach, Marjorie Lee White, Sweta Bhargava, Pavan Zaveri, Elizabeth B Seelbach, Rebekah A Burns, Renuka Mehta, Brett McAninch, Daniel Fein, Todd P Chang, David O Kessler
OBJECTIVES: Few published studies describe graduating pediatric residents' procedural skills or success rates. This information would help guide supervisors' decisions about graduating residents' preparedness, training, and supervision needs. This study aimed to measure success rates for graduating pediatric residents performing infant lumbar puncture (LP) during the final months of their training and to describe their experiences performing and supervising infant LPs during the course of their training...
October 6, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27705180/preschool-predictors-of-school-age-academic-achievement-in-autism-spectrum-disorder
#19
Lauren E Miller, Jeffrey D Burke, Eva Troyb, Kelley Knoch, Lauren E Herlihy, Deborah A Fein
OBJECTIVE: Characterization of academic functioning in children with autism spectrum disorder (ASD), particularly predictors of achievement, may have important implications for intervention. The current study aimed to characterize achievement profiles, confirm associations between academic ability and concurrent intellectual and social skills, and explore preschool predictors of school-age academic achievement in a sample of children with ASD. METHOD: Children with ASD (n = 26) were evaluated at the approximate ages of two, four, and ten...
February 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27696583/yield-and-complications-of-kidney-biopsies-over-two-decades-in-a-tertiary-pediatric-center
#20
Roei Hod Feins, Anna Tobar, Miriam Davidovits
BACKGROUND: Kidney biopsy serves as an adjunct for the diagnosis of renal disease. However, it is not always productive. This study evaluated the yield and risks of kidney biopsies performed in 1995-2014 at a tertiary pediatric medical center. METHODS: The medical files of all patients who underwent closed percutaneous biopsy for various indications in native or transplanted kidneys were retrospectively reviewed for patient characteristics, technical and histopathologic findings, biopsy yield, and biopsy complications...
October 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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