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https://www.readbyqxmd.com/read/29346235/posttraumatic-stress-in-children-after-injury-the-role-of-acute-pain-and-opioid-medication-use
#1
Aimee K Hildenbrand, Nancy Kassam-Adams, Lamia P Barakat, Kristen L Kohser, Jeffrey A Ciesla, Douglas L Delahanty, Joel A Fein, Lindsay B Ragsdale, Meghan L Marsac
OBJECTIVES: After injury, many children experience posttraumatic stress symptoms (PTSS) that negatively impact recovery. Acute pain and PTSS share neurobiological pathways, and acute dosage of morphine has been linked to reduced PTSS in naturalistic studies. However, the complex interactions between pain, morphine and other opioid use, and PTSS have yet to be investigated in robust pediatric samples.This prospective, longitudinal study examined relationships between acute pain, opioid medications, and PTSS after pediatric injury...
January 16, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29318699/-it-breaks-your-soul-an-in-depth-exploration-of-workplace-injustice-in-nursing
#2
Natalie Skinner, Paul Van Dijk, Christina Stothard, Erich C Fein
AIM(S): To understand nurses' experiences of injustice in the workplace and to identify the impact of injustice on well-being. BACKGROUND: Little is known about how nurses view injustice or its effects on their well-being, although research indicates that such perceptions are central to workplace practices such as performance management and outcomes such as employee well-being. METHOD(S): A qualitative study was conducted with semi-structured interviews for nurses employed in Australian public hospitals...
January 10, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29317035/deciphering-the-breast-density-inform-law-movement-implications-for-practice
#3
Sean D Raj, Valerie Fein-Zachary, Priscilla J Slanetz
Although dense breast tissue is a normal and routine finding on screening mammography, dense breast tissue is associated with an independent increased risk for breast cancer. It is well known that screening mammography has a decreased sensitivity for cancer detection in women with dense breasts. Over the past decade, there has been increased interest generated among patients, physicians, and legislators regarding how best to screen dense-breasted women culminating in 2009 with the passage of a breast density notification law in Connecticut...
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29259203/the-evolutionary-landscape-of-chronic-lymphocytic-leukemia-treated-with-ibrutinib-targeted-therapy
#4
Dan A Landau, Clare Sun, Daniel Rosebrock, Sarah E M Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z H Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad Getz, Jan A Burger, Adrian Wiestner, Catherine J Wu
Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by targeted therapy in CLL, we perform serial exome and transcriptome sequencing for 61 ibrutinib-treated CLLs. Here, we report clonal shifts (change >0.1 in clonal cancer cell fraction, Q < 0.1) in 31% of patients during the first year of therapy, associated with adverse outcome. We also observe transcriptional downregulation of pathways mediating energy metabolism, cell cycle, and B cell receptor signaling...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29227816/the-use-of-breast-imaging-for-predicting-response-to%C3%A2-neoadjuvant-lapatinib-trastuzumab-and-their-combination-in-her2-positive-breast-cancer-results%C3%A2-from-neo-altto
#5
S Di Cosimo, C Campbell, H A Azim, G Galli, G Bregni, G Curigliano, C Criscitiello, M Izquierdo, L de la Pena, D Fumagalli, L Fein, J Vinholes, W M J Ng, M Colleoni, A Ferro, B J Naume, A Patel, J Huober, M J Piccart-Gebhart, J Baselga, E de Azambuja
AIM: To determine the value of mammography and breast ultrasound (US) in predicting outcomes in HER2 positive breast cancer patients (pts) within Neo-ALTTO trial. PATIENTS AND METHODS: Mammography and US were required at baseline, week 6 and surgery. Two independent blinded investigators reviewed the measurements and assigned the corresponding response category. Pts showing complete or partial response according to RECIST (v1.1) were classified as responders. The association between imaging response at week 6 or prior to surgery was evaluated with respect to pathological complete response (pCR) and event-free Survival (EFS)...
December 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29198284/facilitating-autism-research
#6
Deborah Fein, Molly Helt
Early autism research focused on behavior and cognition. In recent decades, the pace of research has accelerated, and advances in imaging and genetics have allowed the accumulation of biological data. Nevertheless, a coherent picture of the syndrome at either phenotypic or biological level has not emerged. We see two fundamental obstacles to progress in basic understanding of autism. First, the two defining features (impairment in social interactions and communication, and restricted, repetitive behaviors and interests) are historically seen as integrally related...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29188324/total-vaginectomy-and-urethral-lengthening-at-time-of-neourethral-prelamination-in-transgender-men
#7
Carlos A Medina, Lydia A Fein, Christopher J Salgado
INTRODUCTION AND HYPOTHESIS: For transgender men (TGM), gender-affirmation surgery (GAS) is often the final stage of their gender transition. GAS involves creating a neophallus, typically using tissue remote from the genital region, such as radial forearm free-flap phalloplasty. Essential to this process is vaginectomy. Complexity of vaginal fascial attachments, atrophy due to testosterone use, and need to preserve integrity of the vaginal epithelium for tissue rearrangement add to the intricacy of the procedure during GAS...
November 29, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29159061/eeg-coherence-related-to-fmri-resting-state-synchrony-in-long-term-abstinent-alcoholics
#8
Valerie A Cardenas, Mathew Price, George Fein
Recent work suggests that faulty co-activation or synchrony of multiple brain regions comprising "networks," or an imbalance between opposing brain networks, is important in alcoholism. Previous studies showed higher fMRI resting state synchrony (RSS) within the executive control (inhibitory control and emotion regulation) networks and lower RSS within the appetitive drive network in long-term (multi-year) abstinent alcoholics (LTAA) vs. non substance abusing controls (NSAC). Our goal was to identify EEG networks that are correlated with the appetitive drive and executive function networks identified with fMRI in our previous alcohol studies...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29154538/enhanced-removal-of-dissolved-hg-ii-cd-ii-and-au-iii-from-water-by-bacillus-subtilis-bacterial-biomass-containing-an-elevated-concentration-of-sulfhydryl-sites
#9
Qiang Yu, Jeremy B Fein
In this study, the sorption of Hg(II), Cd(II) and Au(III) onto Bacillus subtilis biomass with an elevated concentration of sulfhydryl sites, induced by adding excess glucose to the growth medium (termed 'High Sulfhydryl Bacillus subtilis' or HSBS) was compared to that onto B. subtilis biomass with a low concentration of sulfhydryl sites (termed 'Low Sulfhydryl Bacillus subtilis' or LSBS) and to sorption onto a commercially available cation exchange resin. Our results show that HSBS exhibits sorption capacities for the three studied metals that are two to five times greater than the sorption capacities of LSBS for these metals...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29128581/trends-in-resource-utilization-and-rate-of-cervical-disc-arthroplasty-and-anterior-cervical-discectomy-and-fusion-throughout-the-united-states-from-2006-to-2013
#10
Comron Saifi, Arielle Fein, Alejandro Cazzulino, Ronald Lehman, Frank M Phillips, Howard S An, K Daniel Riew
BACKGROUND CONTEXT: The typically accepted surgical procedure for cervical disc pathology has been the anterior cervical discectomy and fusion (ACDF), although recent trials have demonstrated equivalent or improved outcomes with cervical disc arthroplasty (CDA). Trends for these two procedures regarding utilization, revision procedures, along with other demographic information have not been sufficiently explored. PURPOSE: To provide data regarding ACDF and CDA from 2006-2013 in the U...
November 8, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29116574/successful-percutaneous-coronary-intervention-significantly-improves-coronary-sinus-blood-flow-as-assessed-by-transthoracic-echocardiography
#11
Radmila Lyubarova, William E Boden, Steven A Fein, Joshua Schulman-Marcus, Mikhail Torosoff
BACKGROUND: Transthoracic echocardiography (TTE) has been used to assess coronary sinus blood flow (CSBF), which reflects total coronary arterial blood flow. Successful angioplasty is expected to improve coronary arterial blood flow. Changes in CSBF after percutaneous coronary intervention (PCI), as assessed by TTE, have not been systematically evaluated. HYPOTHESIS: TTE can be utilized to reflect increased CSBF after a successful, clinically indicated PCI. METHODS: The study cohort included 31 patients (18 females, 62 ± 11 years old) referred for diagnostic cardiac catheterization for suspected coronary artery disease and possible PCI, when clinically indicated...
November 7, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/29112110/methodology-and-demographics-of-a-brief-adolescent-alcohol-screen-validation-study
#12
Julie R Bromberg, Anthony Spirito, Thomas Chun, Michael J Mello, T Charles Casper, Fahd Ahmad, Lalit Bajaj, Kathleen M Brown, Lauren S Chernick, Daniel M Cohen, Joel Fein, Tim Horeczko, Michael N Levas, Brett McAninch, Michael Monuteaux, Colette C Mull, Jackie Grupp-Phelan, Elizabeth C Powell, Alexander Rogers, Rohit P Shenoi, Brian Suffoletto, Cheryl Vance, James G Linakis
OBJECTIVE: The aim of this study was to determine the psychometric properties of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2-question alcohol screen within 16 Pediatric Emergency Care Applied Research Network pediatric emergency departments. This article describes the study methodology, sample characteristics, and baseline outcomes of the NIAAA 2-question screen. METHODS: Participants included 12- to 17-year-olds treated in one of the participating pediatric emergency departments across the United States...
July 3, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29112109/pediatric-emergency-department-and-primary-care-provider-attitudes-on-assessing-childhood-adversity
#13
Samantha Schilling, Ashlee Murray, Cynthia J Mollen, Tara Wedin, Joel A Fein, Philip V Scribano
OBJECTIVE: The purpose of this study was to understand pediatric emergency department (ED) and primary care (PC) health care provider attitudes and beliefs regarding the intersection between childhood adversities and health care. METHODS: We conducted in-depth, semistructured interviews in 2 settings (ED and PC) within an urban health care system. Purposive sampling was used to balance the sample among 3 health care provider roles. Interview questions were based on a modified health beliefs model exploring the "readiness to act" among providers...
July 3, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29111579/knowledge-and-perceptions-of-zika-virus-among-reproductive-aged-women-after-public-announcement-of-local-mosquito-borne-transmission
#14
Christine L Curry, Colette Tse, Victoria Billero, Leah Hellerstein, Marisa Messore, Lydia Fein
AIM: This study was conducted to ascertain the knowledge and perceptions of the Zika virus among reproductive-aged women living in the first affected area of the United States with local mosquito-borne transmission. METHODS: Reproductive-aged women were surveyed during the four weeks immediately following the announcement of local Zika virus transmission. The survey evaluated the participant's knowledge of Zika pathogenesis and transmission, sequelae of infection, epidemiology and public health information...
November 7, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29078908/racial-and-ethnic-disparities-in-treatment-and-survival-of-pediatric-sarcoma
#15
Andrew J Jacobs, Erika B Lindholm, Carolyn Fein Levy, Jonathan D Fish, Richard D Glick
BACKGROUND: Childhood sarcomas are rare and require complex interdisciplinary care including surgery, chemotherapy, and radiation. The goal of this study was to determine if racial or ethnic disparities exist for pediatric sarcoma patients in the United States. METHODS: The United States' National Cancer Institute's Surveillance, Epidemiology, and End Results database was used to identify patients aged 0-21 diagnosed with primary sarcomas from 1973 to 2012. Patients were considered by race and ethnicity...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29072824/introduction-of-a-putative-biocontrol-agent-into-a-range-of-phytoplasma-and-liberibacter-susceptible-crop-plants
#16
Ofir Lidor, Orit Dror, Dor Hamershlak, Nofar Shoshana, Eduard Belausov, Tirtza Zahavi, Netta Mozes-Daube, Vered Naor, Einat Zchori-Fein, Lilach Iasur-Kruh, Ofir Bahar
BACKGROUND: Phytoplasma, the causative agent of bois-noir disease of grapevines, are vectored by the planthopper Hyalesthes obsoletus (Hemiptera: Cixiidae). A Dyella-like bacterium (DLB) isolated from H. obsoletus inhibits the growth of Spiroplasma melliferum, a cultivable relative of phytoplasma. Additional evidence suggests that DLB can reduce the symptoms of yellows disease in grapevine plantlets. The present aim was to test whether DLB could colonize a range of Phytoplasma- and Liberibacter-sensitive crop plants, and thus assess its potential agricultural use...
October 26, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29058986/identification-of-clinical-and-biologic-correlates-associated-with-outcome-in-children-with-adrenocortical-tumors-without-germline-tp53-mutations-a-st-jude-adrenocortical-tumor-registry-and-children-s-oncology-group-study
#17
Emilia Modolo Pinto, Carlos Rodriguez-Galindo, Stanley B Pounds, Lei Wang, Michael R Clay, Geoffrey Neale, Elizabeth A R Garfinkle, Catherine G Lam, Carolyn Fein Levy, Alberto S Pappo, Gerard P Zambetti, Raul C Ribeiro
Purpose The clinical features, pathogenesis, and outcomes in children with adrenocortical tumors (ACTs) without germline TP53 mutations have not been systematically studied. Herein, we describe these correlates and analyze their association with outcome. Patients and Methods Genomic DNA was analyzed for TP53, CTNNB1, CDKN1C, ATRX, and chromosome 11p15 abnormalities. β-catenin expression and Ki-67 labeling index (LI) were evaluated by immunostaining. Primary end points were progression-free (PFS) and overall survival...
December 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28990480/dyella-like-bacterium-isolated-from-an-insect-as-a-potential-biocontrol-agent-against-grapevine-yellows
#18
Lilach Iasur-Kruh, Tirtza Zahavi, Roni Barkai, Shiri Freilich, Einat Zchori-Fein, Vered Naor
Yellows diseases, caused by phytopathogenic bacteria of the genus Phytoplasma, are a major threat to grapevines worldwide. Because conventional applications against this pathogen are inefficient, and disease management is highly challenging, the use of beneficial bacteria has been suggested as a biocontrol solution. A Dyella-like bacterium (DLB), isolated from the Israeli insect vector of grapevine yellows Hyalesthes obsoletus, was suggested to be an endophyte. To test this hypothesis, the bacterium was introduced by spraying the plant leaves, and it had no apparent phytotoxicity to grapevine...
October 9, 2017: Phytopathology
https://www.readbyqxmd.com/read/28987687/incidental-liver-lesions-seen-on-breast-mri-when-is-additional-imaging-warranted
#19
Mark Knox, Priscilla Slanetz, Jordana Phillips, Valerie Fein Zachary, Shambhavi Venkataraman, Vandana Dialani, Tejas Mehta
PURPOSE: Incidental hepatic lesions identified on breast MR can be a diagnostic dilemma due to concern for liver metastases or other significant hepatic lesions. The purpose of this study was to identify the incidence and nature of liver lesions seen on breast MR, and determine if additional imaging is necessary. METHODS AND MATERIALS: Imaging reports of all breast MR examinations performed at our institution from January 1, 2010 to December 31, 2011 were reviewed to identify reports with hepatic abnormalities...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28984482/public-library-staff-as-community-health-partners-training-program-design-and-evaluation
#20
Anna U Morgan, Bernadette A D'Alonzo, Roxanne Dupuis, Eliza D Whiteman, Stacey Kallem, Autumn McClintock, Joel A Fein, Heather Klusaritz, Carolyn C Cannuscio
Public libraries are free and open to all-and accessed at high rates by vulnerable populations-which positions them to be key public health allies. However, library staff themselves often feel ill-equipped to address the health and social concerns of their patrons. To fill this gap, we developed a case-based training curriculum to help library staff recognize, engage, and refer vulnerable patrons to appropriate resources. Topics addressed in the training, including homelessness, mental health and substance use disorders, immigration, and trauma, were selected based on findings from a prior community needs assessment...
October 1, 2017: Health Promotion Practice
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