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C-reactive protein + cognitive impairment in schizophrenia

Błażej Misiak, Bartłomiej Stańczykiewicz, Kamila Kotowicz, Janusz K Rybakowski, Jerzy Samochowiec, Dorota Frydecka
BACKGROUND: The aim of this article was to perform a systematic review of studies investigating the association between peripheral levels of cytokines and C-reactive protein (CRP), cytokine gene polymorphisms and cognition in patients with schizophrenia and bipolar disorder (BD). METHODS: The following databases: PubMed, CINAHL Complete, Academic Search Complete, ERIC and Health Source: Nursing/Academic Edition databases were searched according to the PRISMA guidelines...
April 13, 2017: Schizophrenia Research
Konasale M Prasad, Ashley M Burgess, Matcheri S Keshavan, Vishwajit L Nimgaonkar, Jeffrey A Stanley
INTRODUCTION: Neuropathological studies suggest neuropil reduction in schizophrenia. Altered synaptic pruning is proposed to underlie neuropil reduction. Underlying factors and clinical correlates of synaptic pruning are poorly understood. Using phosphorus magnetic resonance spectroscopy ((31)P MRS), it is feasible to assess membrane phospholipid (MPL) metabolites in the brain that specifically and sensitively reflect neuropil expansion (elevated MPL precursors) or contraction (elevated MPL catabolites)...
November 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
G Fond, F Berna, M Andrianarisoa, O Godin, M Leboyer, L Brunel, B Aouizerate, D Capdevielle, I Chereau, T D'Amato, H Denizot, C Dubertret, J Dubreucq, C Faget, F Gabayet, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Richieri, R Rey, A Schandrin, M Urbach, P Vidailhet, L Boyer, F Schürhoff
Chronic peripheral inflammation (CPI) has been associated with cognitive impairment in schizophrenia (SZ). However, its sources remain unclear, more specifically it is not known whether tobacco smoking is a source of inflammation or not in SZ subjects. Moreover, nicotine (NIC), the major psychoactive compound of tobacco, shows strong anti-inflammatory properties in vitro, as well as inducing a severe biological dependence when administered repeatedly. The objective of the present study was to determine if CPI was associated with tobacco smoking and/or NIC dependence in schizophrenia...
August 2017: European Archives of Psychiatry and Clinical Neuroscience
Michele Fonseca Vieira Szortyka, Viviane Batista Cristiano, Keila Maria Ceresér, Lenise Petter Francesconi, Maria Inês Lobato, Clarissa Gama, Paulo Belmonte-de-Abreu
INTRODUCTION: Schizophrenia is a severe, debilitating mental disorder that affects both the physical health and the functional capacity of patients, causing great impairment throughout the life course. Although physical and cognitive impairments may represent different expressions of a single systemic inflammatory process, little is known about the relationship between motor function and schizophrenia. OBJECTIVE: To evaluate physical functional capacity in patients with schizophrenia and ascertain whether it correlates with markers of inflammation, disease severity, and pharmacotherapy...
2016: Frontiers in Psychiatry
Ewa Bulzacka, Laurent Boyer, Franck Schürhoff, Ophélia Godin, Fabrice Berna, Lore Brunel, Méja Andrianarisoa, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chéreau-Boudet, Gabrielle Chesnoy-Servanin, Jean-Marie Danion, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Franck Gabayet, Tifenn Le Gloahec, Pierre-Michel Llorca, Jasmina Mallet, David Misdrahi, Romain Rey, Raphaëlle Richieri, Christine Passerieux, Paul Roux, Hanan Yazbek, Marion Leboyer, Guillaume Fond
OBJECTIVES: Inflammation, measured by abnormal blood C-reactive protein (CRP) level, has been described in schizophrenia (SZ), being inconsistently related to impaired cognitive functions. The aim of the present study is to investigate cognitive impairment associated with abnormal CRP levels in a large multi-centric sample of community-dwelling SZ patients, using a comprehensive neuropsychological battery. METHOD: Three hundred sixty-nine community-dwelling stable SZ subjects (76...
September 2016: Schizophrenia Bulletin
Jamie Joseph, Colin Depp, Averria Sirkin Martin, Rebecca E Daly, Danielle K Glorioso, Barton W Palmer, Dilip V Jeste
Schizophrenia is characterized by physical (mainly metabolic and cardiovascular) comorbidity and shortened lifespan. High sensitivity C-reactive protein (hs-CRP), an inflammatory marker of hepatic origin linked to metabolic and cardiovascular diseases and mortality in the general population, has been reported to be elevated in people with schizophrenia. However, the relationship of hs-CRP to psychiatric and medical risk factors, after controlling for potentially confounding variables such as smoking, is not well established in schizophrenia...
October 2015: Schizophrenia Research
Heidi M Rivera, Kelly J Christiansen, Elinor L Sullivan
Recent evidence indicates that perinatal exposure to maternal obesity, metabolic disease, including diabetes and hypertension, and unhealthy maternal diet has a long-term impact on offspring behavior and physiology. During the past three decades, the prevalence of both obesity and neuropsychiatric disorders has rapidly increased. Epidemiologic studies provide evidence that maternal obesity and metabolic complications increase the risk of attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, anxiety, depression, schizophrenia, eating disorders (food addiction, anorexia nervosa, and bulimia nervosa), and impairments in cognition in offspring...
2015: Frontiers in Neuroscience
Sigrun Hope, Eva Hoseth, Ingrid Dieset, Ragni H Mørch, Monica Aas, Pål Aukrust, Srdjan Djurovic, Ingrid Melle, Torill Ueland, Ingrid Agartz, Thor Ueland, Lars T Westlye, Ole A Andreassen
BACKGROUND: The mechanisms underlying cognitive impairment in schizophrenia and bipolar disorders are largely unknown. Immune abnormalities have been found in both disorders, and inflammatory mediators may play roles in cognitive function. We investigated if inflammatory markers are associated with general cognitive abilities. METHODS: Participants with schizophrenia spectrum (N=121) and bipolar spectrum (N=111) disorders and healthy controls (N=241) were included...
July 2015: Schizophrenia Research
Dorota Frydecka, Błażej Misiak, Edyta Pawlak-Adamska, Lidia Karabon, Anna Tomkiewicz, Paweł Sedlaczek, Andrzej Kiejna, Jan Aleksander Beszłej
The influence of the immune system deregulation on the risk of schizophrenia is increasingly recognized. The aim of this study was to assess the influence of serum interleukin-6 (IL-6) level together with the polymorphism in its gene (IL6 -174G/C) and high sensitivity C-reactive protein (hsCRP) levels on clinical manifestation and cognition in schizophrenia patients. We recruited 151 patients with schizophrenia and 194 healthy control subjects. Psychopathology was evaluated using Operational Criteria for Psychotic Illness checklist, Positive and Negative Syndrome Scale (PANSS) and Scales for Assessment of Positive and Negative Symptoms...
September 2015: European Archives of Psychiatry and Clinical Neuroscience
Faith Dickerson, Cassie Stallings, Andrea Origoni, Crystal Vaughan, Sunil Khushalani, Robert Yolken
OBJECTIVES: We investigated the effect of elevated levels of C-reactive protein (CRP) and exposure to Herpes simplex virus type 1 (HSV-1) on the severity of cognitive impairment in individuals with schizophrenia. METHODS: We measured the levels of CRP and of antibodies to HSV-1 in serum samples from 588 individuals with schizophrenia by enzyme immunoassay tests. Cognitive functioning was measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and psychiatric symptoms with the Positive and Negative Syndrome Scale (PANSS)...
January 2012: Schizophrenia Research
Parris M Kidd
The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are orthomolecular, conditionally essential nutrients that enhance quality of life and lower the risk of premature death. They function exclusively via cell membranes, in which they are anchored by phospholipid molecules. DHA is proven essential to pre- and postnatal brain development, whereas EPA seems more influential on behavior and mood. Both DHA and EPA generate neuroprotective metabolites. In double-blind, randomized, controlled trials, DHA and EPA combinations have been shown to benefit attention deficit/hyperactivity disorder (AD/HD), autism, dyspraxia, dyslexia, and aggression...
September 2007: Alternative Medicine Review: a Journal of Clinical Therapeutic
Faith Dickerson, Cassie Stallings, Andrea Origoni, John Boronow, Robert Yolken
OBJECTIVES: We investigated the association between serum levels of C-reactive protein (CRP), a marker of inflammation, and the severity of psychopathology and cognitive impairment in schizophrenia. METHODS: We measured the levels of CRP in N=413 individuals with schizophrenia. Symptom severity was evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functioning with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)...
July 2007: Schizophrenia Research
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