Yanfang Zhou, Junchao Huang, Ping Zhang, Jinghui Tong, Fengmei Fan, Mengzhuang Gou, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Wei Feng, Fude Yang, Baopeng Tian, Li Tian, Anya Savransky, Stephanie Hare, Meghann C Ryan, Eric Goldwaser, Joshua Chiappelli, Shuo Chen, Peter Kochunov, Mark Kvarta, Yunlong Tan, L Elliot Hong
Reduced cortical gray matter integrity and cognitive abilities are among core deficits in schizophrenia. We hypothesized that higher allostatic load (AL) that accounts for exposure to chronic stress is a contributor to structural and cognitive deficits in schizophrenia. One hundred and sixty-seven schizophrenia patients who were on average with normal weight, normal systolic, and diastolic blood pressure and 72 healthy controls were enrolled in the study. Group differences in subclinical cardiovascular, metabolic, immune, and neuroendocrine biological markers as indexed by AL and contribution of AL components to the structural and cognitive deficits in schizophrenia were explored...
July 8, 2021: Schizophrenia Bulletin