keyword
MENU ▼
Read by QxMD icon Read
search

Conceive

keyword
https://www.readbyqxmd.com/read/29775803/assisted-reproductive-technologies-and-imprinting-disorders-results-of-a-study-from-a-french-congenital-malformations-registry
#1
Audrey Uk, Sophie Collardeau-Frachon, Quentin Scanvion, Lucas Michon, Emmanuelle Amar
INTRODUCTION: Assisted Reproductive Technologies (ART) is increasingly used to help infertile couples to have children around the world. A number of studies have been published reporting an increased risk of major malformations in children born following ART, especially an increased incidence of epigenetic diseases (ED). This study aimed to assess the incidence of epigenetic diseases with affected imprinting genes in infants or children from pregnancies obtained through IVF/ICSI compared to infants or children from pregnancies obtained spontaneously...
May 15, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29775743/redox-regulation-of-protein-kinase-c-by-selenometabolites-and-selenoprotein-thioredoxin-reductase-limits-cancer-prevention-by-selenium
#2
REVIEW
Rayudu Gopalakrishna, Usha Gundimeda, Sarah Zhou, Bui Helena, Arne Holmgren
The cancer-preventive mechanism of selenium should address the way low concentrations of selenometabolites react with cellular targets without being diffused from the sites of generation, the way selenium selectively kills tumor cells, and the intriguing U-shaped curve that is seen with dietary supplementation of selenium and cancer prevention. Protein kinase C (PKC), a receptor for tumor promoters, is well suited for this mechanism. Due to the catalytic redox cycle, low concentrations of methylselenol, a postulated active metabolite of selenium, react with the tumor-promoting lipid hydroperoxide bound to PKC to form methylseleninic acid (MSA), which selectively reacts with thiol residues present within the vicinity of the PKC catalytic domain to inactivate it...
May 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29775648/towards-a-quantitative-model-to-predict-the-toxicity-pathogenicity-potential-of-mineral-fibers
#3
Alessandro F Gualtieri
A number of mineral fibers represent a health hazard because they are classified as cancer-causing chemical/physical toxicants upon (chronic) dust inhalation. Although in the last decades they have been the subject of intensive multidisciplinary investigations, the mechanisms by which mineral fibers induce toxic and pathogenic adverse effects on human health and environment are not yet fully understood. The major intricacy of the biological approach that prevents the design of a conclusive shared model of behavior of mineral fibers in a biological system stems from their very nature with intrinsic variability in chemical, molecular, structural and morphometric parameters, biodurability and surface reactivity...
May 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29774056/epigenetic-regulation-of-inflammation-in-stroke
#4
REVIEW
Gavin Yong-Quan Ng, Lim Yun-An, Christopher G Sobey, Thameem Dheen, David Yang-Wei Fann, Thiruma V Arumugam
Despite extensive research, treatments for clinical stroke are still limited only to the administration of tissue plasminogen activator and the recent introduction of mechanical thrombectomy, which can be used in only a limited proportion of patients due to time constraints. A plethora of inflammatory events occur during stroke, arising in part due to the body's immune response to brain injury. Neuroinflammation contributes significantly to neuronal cell death and the development of functional impairment and death in stroke patients...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29772406/fertility-pregnancy-and-clinical-outcomes-after-uterine-arteriovenous-malformation-management
#5
Sophie Delplanque, Maela Le Lous, Maïa Proisy, Yolaine Joueidi, Estelle Bauville, Celine Rozel, Eugénie Beraud, Bertrand Bruneau, Jean Levêque, Vincent Lavoué, Krystel Nyangoh Timoh
STUDY OBJECTIVE: To evaluate fertility, pregnancy, and clinical outcomes after uterine arteriovenous malformation (UAVM) management. DESIGN: Single-center retrospective study from January 2000 to July 2017. (Canadian task force III). SETTING: One referral center. PATIENTS: Twenty-two patients with a UAVM diagnosed by Magnetic Resonance Angiography (MRA) or Computed Tomography (CT) angiography and managed by Expectant Management (EM) or Uterine Arterial Embolization (UAE) during the study period were included...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29771226/sanokondu
#6
Jamiu Busari, Ming-Ka Chan, Deepak Dath, Anne Matlow, Diane de Camps Meschino
Purpose This paper aims to describe the evolution of Sanokondu, highlighting the rationale, achievements and lessons learnt from this initiative. Sanokondu is a multinational community of practice dedicated to fostering health-care leadership education worldwide. This platform for health-care leadership education was conceived in 2014 at the first Toronto International Summit on Leadership Education for Physicians (TISLEP) and evolved into a formal network of collaborators in 2016. Design/methodology/approach This paper is a case study of a multinational collaboration of health-care leaders, educators, learners and other stakeholders...
May 8, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29771194/preconception-antiphospholipid-antibodies-and-risk-of-subsequent-early-pregnancy-loss
#7
K J Gibbins, S L Mumford, L A Sjaarda, D W Branch, N J Perkins, A Ye, E F Schisterman, R M Silver
Objectives To prospectively estimate the association of preconception antiphospholipid antibodies (aPL) with subsequent pregnancy loss using a cohort design. aPL have been associated with recurrent early pregnancy loss (EPL) prior to 10 weeks in previous case-control studies. Prospective ascertainment of pregnancy loss is challenging, as most women do not seek care prior to EPL. Methods Secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial of preconception low-dose aspirin. Preconception anticardiolipin (aCL) and anti-β2-glycoprotein-I (a-β2-I) were assessed in 1208 women with one or two prior pregnancy losses and no more than two prior live births...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29770459/identification-of-correlative-shifts-in-indices-of-brain-cholesterol-metabolism-in-the-c57bl6-mecp2-tm1-1bird-mouse-a-model-for-rett-syndrome
#8
Dieter Lütjohann, Adam M Lopez, Jen-Chieh Chuang, Anja Kerksiek, Stephen D Turley
Rett syndrome (RS) is a pervasive neurodevelopmental disorder resulting from loss-of-function mutations in the X-linked gene methyl-Cpg-binding protein 2 (MECP2). Using a well-defined model for RS, the C57BL6/Mecp2 tm1.1Bird mouse, we have previously found a moderate but persistently lower rate of cholesterol synthesis, measured in vivo, in the brains of Mecp2 -/y mice, starting from about the third week after birth. There was no genotypic difference in the total cholesterol concentration throughout the brain at any age...
May 17, 2018: Lipids
https://www.readbyqxmd.com/read/29769182/clinical-pharmacodynamics-principles-of-drug-response-and-alterations-in-kidney-disease
#9
Frieder Keller, Alexander Hann
Pharmacokinetics and pharmacodynamics follow the logic of cause and consequence. Receptor-mediated and reversible effects can be distinguished from direct and irreversible effects. Reversible effects are capacity-limited and saturable whereas irreversible effects are limited only by the number of viable targets. In the case of receptor-mediated and reversible effects a threshold and a ceiling concentration can be defined. Antimicrobial drugs with concentration-dependent action are distinguished from drugs with time-dependent action...
May 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29767340/speculation-as-to-why-the-frequency-of-eosinophilic-esophagitis-is-increasing
#10
REVIEW
Stuart Jon Spechler
PURPOSE OF REVIEW: The frequency of eosinophilic esophagitis (EoE), an immune/antigen-mediated disorder first described in 1993, has been increasing rapidly. The purpose of this review is to consider hypotheses proposed to explain this increase and to speculate on their validity. RECENT FINDINGS: The hygiene hypothesis attributes the rise of EoE to modern hygienic conditions resulting in fewer childhood infections with microbes that might have protected against allergy development...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29767306/correction-to-results-of-nimotuzumab-and-vinorelbine-radiation-and-re-irradiation-for-diffuse-pontine-glioma-in-childhood
#11
Maura Massimino, Veronica Biassoni, Rosalba Miceli, Elisabetta Schiavello, Monika Warmuth-Metz, Piergiorgio Modena, Michela Casanova, Emilia Pecori, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Paolo Potepan, Bianca Pollo, Raffaele Nunziata, Filippo Spreafico, Marta Podda, Andrea Anichini, Carlo Alfredo Clerici, Iacopo Sardi, Loris De Cecco, Udo Bode, Ferdinand Bach, Lorenza Gandola
The therapeutic experience reported in the paper was conceived after the use of nimotuzumab and radiotherapy (BSCPED-05 international multicentric trial, EUDRACT 2005-003100-11) in 2009 when we decided to explore the activity of the same combination plus vinorelbine (see the paper for the rationale).
May 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29766617/gingival-tissue-reaction-to-direct-adhesive-restoration-a-preliminary-study
#12
Carlo Bertoldi, Davide Zaffe, Luigi Generali, Andrea Lucchi, Pierpaolo Cortellini, Emanuela Monari
INTRODUCTION: It is debated if composite resin marginal/submarginal direct restoration can be usefully performed without inflammatory consequences. This histological study is the first human analysis aimed to compare, in the same tooth, the gingival tissue close to composite resin restorations with gingival tissue close to hard tissue. METHODS: Eight healthy patients with almost a residual strategic tooth needing endodontic therapy, and post-and-core restoration, then indirect prosthetic restoration, were selected...
May 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29765469/an-efficient-and-facile-access-to-highly-functionalized-pyrrole-derivatives
#13
Meng Gao, Wenting Zhao, Hongyi Zhao, Ziyun Lin, Dongfeng Zhang, Haihong Huang
A straightforward and one-pot synthesis of pyrrolo[3,4- c ]pyrrole-1,3-diones via Ag(I)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with N -alkyl maleimide, followed by readily complete oxidation with DDQ, has been successfully developed. Further transformation with alkylamine/sodium alkoxide alcohol solution conveniently afforded novel polysubstituted pyrroles in good to excellent yields. This methodology for highly functionalized pyrroles performed well over a broad scope of substrates. It is conceivable that this efficient construction method for privileged pyrrole scaffolds could deliver more active compounds for medicinal chemistry research...
2018: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29762560/microwave-photonics-instantaneous-frequency-measurement-receiver-based-on-a-sagnac-loop
#14
Hossein Emami, Mohammadreza Hajihashemi, Sayed Ehsan Alavi, Abu Sahmah Mohd Supaat
A microwave photonics instantaneous frequency measurement receiver was conceived and practically demonstrated. The system is based on phase modulation inside a Sagnac loop and therefore needs no bias voltage, resulting in no DC bias drifts. The system provides a DC output whose amplitude is a function of input signal frequency, and thus no high-frequency photo-detector is required. Furthermore, the system exhibits a very good sensitivity without the aid of any sort of electrical noise cancellation techniques, such as lock-in amplification...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29761575/different-selectivities-in-the-insertions-into-c-sp2-h-bonds-benzofulvenes-by-dual-gold-catalysis-competition-experiments
#15
Alex Plajer, Lukas Ahrens, Marcel Wieteck, Danilo M Lustosa, Rasool BabaAhmadi, Brian Yates, Alireza Ariafard, Matthias Rudolph, Frank Rominger, A Stephen K Hashmi
An unprecedented, often almost quantitative access to tricyclic aromatic compounds by dual gold catalysis was developed. This synthetic route expands the scope of benzofulvene derivatives through a C(sp2)-H bond insertion in easily available starting materials. The insertion takes place with an exclusive chemoselectivity with respect to the competing aromatic C-H positions. A bidirectional synthesis with two competing ortho-aryl C,H bonds in the selectivity-determining step also shows perfect selectivity; this result is explained by a computational investigation of the two conceivable intermediates...
May 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29760146/copper-acyl-salicylate-has-potential-as-an-anti-cryptococcus-anti-fungal-agent
#16
Adepemi O Ogundeji, Boitumelo F Porotloane, Carolina H Pohl, Pravin S Kendrekar, Olihile M Sebolai
The in vitro anti-fungal activity of aspirin against cryptococcal cells has been reported. However, its undesired effects may limit its clinical application. Conceivably, a derivative of aspirin could overcome this challenge. Toward this end, this paper considered the usage of an aspirinate-metal complex viz. copper acyl salicylate (CAS) as an anti- Cryptococcus anti-fungal agent. Additionally, the paper examined the influence of this compound on macrophage function. The in vitro susceptibility results revealed that cryptococcal cells were vulnerable (in a dose-dependent manner) to CAS, which may have effected growth inhibition by damaging cryptococcal cell membranes...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758683/markovian-robots-minimal-navigation-strategies-for-active-particles
#17
Luis Gómez Nava, Robert Großmann, Fernando Peruani
We explore minimal navigation strategies for active particles in complex, dynamical, external fields, introducing a class of autonomous, self-propelled particles which we call Markovian robots (MR). These machines are equipped with a navigation control system (NCS) that triggers random changes in the direction of self-propulsion of the robots. The internal state of the NCS is described by a Boolean variable that adopts two values. The temporal dynamics of this Boolean variable is dictated by a closed Markov chain-ensuring the absence of fixed points in the dynamics-with transition rates that may depend exclusively on the instantaneous, local value of the external field...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29757507/mosquito-traps-for-urban-surveillance-collection-efficacy-and-potential-for-use-by-citizen-scientists
#18
Mathieu Bazin, Craig R Williams
Mosquito-borne diseases are a pervasive public health problem on a global scale, and effective management of them requires well-designed surveillance programs for both vectors and pathogens. Mosquito traps are a common component of such programs, and their reach can be expanded by engaging citizen scientists. In this study in a southern Australian city, we compared the mosquito collection efficacy of two types of traps and assessed their suitability for use in citizen science programs. BG Sentinels and BG Gravid Aedes Trap (BG-GAT) traps both collected Aedes and Culex species in similar proportions, albeit with the former collecting approximately nine times as many mosquitoes...
June 2018: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/29756614/transoral-glossoepiglottopexy-in-the-treatment-of-adult-obstructive-sleep-apnoea-a-surgical-approach
#19
V Roustan, M Barbieri, F Incandela, F Missale, H Camera, F Braido, R Mora, G Peretti
The treatment of obstructive sleep apnoea syndrome (OSAS) is still a matter of debate; among the different therapeutic alternatives, both surgical and conservative, treatment with continuous positive airway pressure (CPAP) is considered the "gold standard". The recent scientific literature reports that even if CPAP represents an effective solution for sleep apnoeas, 12% of patients do not benefit from its use. In most cases, primary collapse of the epiglottis is responsible for failure. We developed a surgical technique that provides a stable support to the epiglottis without influencing its function during swallowing while preserving laryngeal anatomy and physiology...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29756495/historicizing-transcultural-psychiatry-people-epistemic-objects-networks-and-practices
#20
Emmanuel Delille, Ivan Crozier
The history of transcultural psychiatry has recently attracted much historical attention, including a workshop in March 2016 in which an international panel of scholars met at the Maison de Sciences de l'Homme Paris-Nord (MSH-PN). Papers from this workshop are presented here. By conceiving of transcultural psychiatry as a dynamic social field that frames its knowledge claims around epistemic objects that are specific to the field, and by focusing on the ways that concepts within this field are used to organize intellectual work, several themes are explored that draw this field into the historiography of psychiatry...
May 1, 2018: History of Psychiatry
keyword
keyword
8302
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"