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https://www.readbyqxmd.com/read/28229988/endometrial-microrna-signature-during-the-window-of-implantation-changed-in-patients-with-repeated-implantation-failure
#1
Cheng Shi, Huan Shen, Li-Juan Fan, Jing Guan, Xin-Bang Zheng, Xi Chen, Rong Liang, Xiao-Wei Zhang, Qing-Hua Cui, Kun-Kun Sun, Zhu-Ran Zhao, Hong-Jing Han
BACKGROUND: At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA (miRNA) signatures for impaired endometrial receptivity by microarray analysis. METHODS: A total of 12 repeated implantation failure (RIF) patients and 10 infertile patients, who conceived and delivered after one embryo transfer attempt, were recruited as RIF and control groups, respectively...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28227238/design-and-development-of-a-sensorized-cylindrical-object-for-grasping-assessment
#2
F Cordella, F Taffoni, L Raiano, G Carpino, M Pantoni, L Zollo, E Schena, E Guglielmelli, D Formica, F Cordella, F Taffoni, L Raiano, G Carpino, M Pantoni, L Zollo, E Schena, E Guglielmelli, D Formica, M Pantoni, F Cordella, G Carpino, E Schena, L Zollo, D Formica, F Taffoni, L Raiano, E Guglielmelli
Aim of this work is to design and develop an instrumented cylindrical object equipped with force sensors, which is able to assess grasping performance of both human and robotic hands. The object is made of two concentric shells between which sixteen piezoresistive sensors have been located in order to measure the forces applied by the hand fingers during grasping. Furthermore, a magneto-inertial unit has been positioned inside the object for acquiring information about object orientation during manipulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226902/investigation-on-the-hermeticity-of-an-implantable-package-with-32-feedthroughs-for-neural-prosthetic-applications
#3
Lorenzo Bisoni, Matthias Mueller, Paul Cvancara, Caterina Carboni, Roberto Puddu, Luigi Raffo, Massimo Barbaro, Thomas Stieglitz, Lorenzo Bisoni, Matthias Mueller, Paul Cvancara, Caterina Carboni, Roberto Puddu, Luigi Raffo, Massimo Barbaro, Thomas Stieglitz, Roberto Puddu, Luigi Raffo, Lorenzo Bisoni, Matthias Mueller, Paul Cvancara, Caterina Carboni, Massimo Barbaro, Thomas Stieglitz
This paper presents an implantable package aimed at hosting a bidirectional neural interface for neural prosthetic applications. The package has been conceived to minimize the invasivity for the patient, for this reason a cylindrical container with an outer diameter of 7 mm and a length of 21 mm has been designed. The package, realized in alumina (Al2O3), presents 32 hermetic feedthroughs located at the top and bottom base of the cylinder. The hermetic housing has been assembled using a low-temperature soldering method based on a previous platinum/gold (Pt/Au) metallization of the ceramic parts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225694/polarities-in-clinical-thinking-and-practice
#4
John Z Sadler
This analysis of a case of a bereaved patient that poses two treatment options-watchful waiting or medication-focuses on five "polarities" in clinical practice: (1) the normal and the pathological, (2) the individual and the diagnostic collective, (3) the primary care physician and the consultant, (4) the expert and nonexpert, and (5) the moment and the process. These polarities can accentuate ethical problems posed by this case, for example, by creating stark contrasts that mask the complex contexts of care and characteristics of patients...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28224825/heavy-lifting-and-shift-work-linked-to-lowered-fertility-in-women
#5
(no author information available yet)
Women who work shifts or have a physically demanding job may be less likely to conceive due to poorer egg quality, new study results suggest.
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28223512/glucosylceramide-synthase-inhibition-alleviates-aberrations-in-synucleinopathy-models
#6
S Pablo Sardi, Catherine Viel, Jennifer Clarke, Christopher M Treleaven, Amy M Richards, Hyejung Park, Maureen A Olszewski, James C Dodge, John Marshall, Elina Makino, Bing Wang, Richard L Sidman, Seng H Cheng, Lamya S Shihabuddin
Mutations in the glucocerebrosidase gene (GBA) confer a heightened risk of developing Parkinson's disease (PD) and other synucleinopathies, resulting in a lower age of onset and exacerbating disease progression. However, the precise mechanisms by which mutations in GBA increase PD risk and accelerate its progression remain unclear. Here, we investigated the merits of glucosylceramide synthase (GCS) inhibition as a potential treatment for synucleinopathies. Two murine models of synucleinopathy (a Gaucher-related synucleinopathy model, Gba(D409V/D409V) and a A53T-α-synuclein overexpressing model harboring wild-type alleles of GBA, A53T-SNCA mouse model) were exposed to a brain-penetrant GCS inhibitor, GZ667161...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223181/the-effect-of-salpingectomy-on-ovarian-function
#7
REVIEW
Alexander Kotlyar, Julian Gingold, Shirley Shue, Tommaso Falcone
OBJECTIVE: To review the literature concerning the effects of salpingectomy on ovarian function as assessed using measures of ovarian reserve and outcomes from in-vitro fertilization and spontaneous pregnancy cycles. BACKGROUND: Tubal surgery is performed for a variety of indications in gynecology. Salpingectomy is the most aggressive form of tubal surgery and may be performed for potential risk reduction for epithelial ovarian cancer, sterilization, ectopic pregnancy and as a method to enhance fertility in the setting of a hydrosalpinx...
February 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28222976/-five-paradoxes-in-health-promotion
#8
Olga López-Dicastillo, Navidad Canga-Armayor, Agurtzane Mujika, Miren Idoia Pardavila-Belio, Maider Belintxon, Inmaculada Serrano-Monzó, María J Pumar-Méndez
The World Health Organization states that health promotion is a key strategy to improve health, and it is conceived as a global process of enabling people to increase control over, and to improve, their health. Health promotion does not focus solely on empowering individuals dealing with their knowledge, attitudes and skills, but it also takes political, social, economic and environmental aspects influencing health and wellbeing into account. The complexity of applying these concepts is reflected in the five paradoxes in health promotion; these arise in between the rhetoric in health promotion and implementation...
February 17, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28221050/young-children-s-understanding-of-the-limits-and-benefits-of-group-ownership
#9
Michelle Huh, Ori Friedman
Group ownership is ubiquitous-property is owned by countries, corporations, families, and clubs. However, people cannot understand group ownership by simply relying on their conceptions of ownership by individuals, as group ownership is subject to complexities that do not arise when property is individually owned. We report 6 experiments investigating whether children ages 3 to 6 (N = 540) understand group ownership. In Experiments 1 and 2 children were asked who different objects belong to, and they appropriately judged that certain objects are more likely to belong to a group than to individual people...
February 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28220319/cfd-assessment-of-the-effect-of-convective-mass-transport-on-the-intracellular-clearance-of-intracellular-triglycerides-in-macrosteatotic-hepatocytes
#10
Gabriel Yarmush, Lucas Santos, Joshua Yarmush, Srivathsan Koundinyan, Mubasher Saleem, Nir I Nativ, Martin L Yarmush, Francois Berthiaume, Timothy J Maguire, Chris Guaghan
Donor livers available to transplant for patients with end-stage liver disease are in severe shortage. One possible avenue to expand the donor pool is to recondition livers that would be otherwise discarded due to excessive fat content. Severely steatotic livers (also known as fatty livers) are highly susceptible to ischemia-reperfusion injury and as a result, primary liver non-function post-transplantation. Prior studies in isolated perfused rat livers suggest that "defatting" may be possible in a timeframe of a few hours; thus, it is conceivable that fatty liver grafts could be recovered by machine perfusion to clear stored fat from the organ prior to transplantation...
February 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28219359/congenital-tuberculosis-in-an-extremely-preterm-infant-conceived-after-in-vitro-fertilization-case-report
#11
Veronica Samedi, Stephen K Field, Essa Al Awad, Gregory Ratcliffe, Kamran Yusuf
BACKGROUND: Congenital tuberculosis is a rare manifestation of tuberculosis. The diagnosis is often delayed, especially in preterm neonates because of the non-specific clinical presentation and the lack of awareness of maternal disease prior to pregnancy. CASE PRESENTATION: We report a case of congenital tuberculosis in an infant born at 24 weeks of gestation to a mother who presented with uncontrolled seizures during preterm labor. Maternal diagnosis was initially made by placental pathology, and later confirmed by isolation of Mycobacterium tuberculosis in urine, gastric aspirates and sputum...
February 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28218613/first-experimental-comparison-between-the-cartesian-and-the-lissajous-trajectory-for-magnetic-particle-imaging
#12
Franziska Werner, Nadine Gdaniec, Tobias Knopp
Magnetic Particle Imaging (MPI) is a quantitative imaging modality that allows to determine the distribution of superparamagnetic nanoparticles. Sampling is achieved by moving a field-free point (FFP) along a specific trajectory through the volume of interest. The magnetic material that lies along the path or in the close vicinity of the FFP changes its magnetization and induces a voltage in surrounding receive coils. Various trajectories for the FFP are conceivable, but most experimental MPI scanners either use a Cartesian or a Lissajous sampling trajectory...
February 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28218216/effects-of-previous-laparoscopic-surgical-diagnosis-of-endometriosis-on-pregnancy-outcomes
#13
Hui Li, Hong-Lan Zhu, Xiao-Hong Chang, Yi Li, Yue Wang, Jing Guan, Heng Cui
BACKGROUND: The association between the previous history of endometriosis and obstetric outcomes is still ambiguous. This study aimed to evaluate the effects of previous history of operatively diagnosed endometriosis on pregnancy outcomes. METHODS: A total of 98 primiparous women who had been diagnosed with endometriosis by previous laparoscopic surgery were included in this retrospective cohort study. Pregnancy outcomes were compared between these women (study group) who had a live birth and 300 women without endometriosis (control group) who had a live birth...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28217573/return-to-sports-after-acl-reconstruction-a-new-functional-test-protocol
#14
Gian Nicola Bisciotti, Alessandro Quaglia, Andrea Belli, Giulia Carimati, Piero Volpi
BACKGROUND: In literature, there are lack of studies proposing clear and rationally designed test battery to be performed after an ACL reconstruction. METHODS: From 2006 to 2015, 80 football players were subjected, after ACL reconstruction, to a newly conceived test battery analyzing: Isometric and isokinetic force productionThe different phases during the jumpThe correct control of the landing phase after jumpThe control of valgus during landing after jump and cutting movements...
October 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28215693/incidence-of-double-ovulation-during-the-early-postpartum-period-in-lactating-dairy-cows
#15
Hiromi Kusaka, Hiroshi Miura, Motohiro Kikuchi, Minoru Sakaguchi
In lactating cattle, the incidence of twin calving has many negative impacts on production and reproduction in dairy farming. In almost all cases, natural twinning in dairy cattle is the result of double ovulation. It has been suggested that the milk production level of cows influences the number of ovulatory follicles. The objective of the present study was to investigate the incidence of double ovulations during the early postpartum period in relation to the productive and reproductive performance of dairy cows...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28215518/rational-engineering-of-diol-dehydratase-enables-1-4-butanediol-biosynthesis-from-xylose
#16
Jia Wang, Rachit Jain, Xiaolin Shen, Xinxiao Sun, Mengyin Cheng, James C Liao, Qipeng Yuan, Yajun Yan
Establishing novel synthetic routes for microbial production of chemicals often requires overcoming pathway bottlenecks by tailoring enzymes to enhance bio-catalysis or even achieve non-native catalysis. Diol dehydratases have been extensively studied for their interactions with C2 and C3 diols. However, attempts on utilizing these insights to enable catalysis on non-native substrates with more than two hydroxyl groups have been plagued with low efficiencies. Here, we rationally engineered the Klebsiella oxytoca diol dehydratase to enable and enhance catalytic activity toward a non-native C4 triol, 1,2,4-butanetriol...
February 13, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28212653/coordination-between-primary-and-secondary-care-the-role-of-electronic-messages-and-economic-incentives
#17
Antonella La Rocca, Thomas Hoholm
BACKGROUND: In Norway, a government reform has recently been introduced to enhance coordination between primary and secondary care. This paper examines the effects of two newly introduced measures to improve the coordination: an ICT-based communication tool/standard and an economic incentive scheme. METHOD: This qualitative study is based primarily on 27 open-ended interviews. We interviewed nine employees at a hospital (the focal actor), 17 employees from seven different municipalities, and a representative of a Regional Health Authority...
February 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28211887/germline-mutations-predisposing-to-diffuse-large-b-cell-lymphoma
#18
REVIEW
O C Leeksma, N F de Miranda, H Veelken
Genetic studies of diffuse large B-cell lymphomas (DLBCLs) in humans have revealed numerous targets of somatic mutations and an increasing number of potentially relevant germline alterations. The latter often affect genes involved in DNA repair and/or immune function. In general, defects in these genes also predispose to other conditions. Knowledge of these mutations can lead to disease-preventing measures in the patient and relatives thereof. Conceivably, these germline mutations will be taken into account in future therapy of the lymphoma...
February 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28211527/depth-specific-fluctuations-of-gene-expression-and-protein-abundance-modulate-the-photophysiology-in-the-seagrass-posidonia-oceanica
#19
Gabriele Procaccini, Miriam Ruocco, Lázaro Marín-Guirao, Emanuela Dattolo, Christophe Brunet, Daniela D'Esposito, Chiara Lauritano, Silvia Mazzuca, Ilia Anna Serra, Letizia Bernardo, Amalia Piro, Sven Beer, Mats Björk, Martin Gullström, Pimchanok Buapet, Lina M Rasmusson, Paulo Felisberto, Sylvie Gobert, John W Runcie, João Silva, Irene Olivé, Monya M Costa, Isabel Barrote, Rui Santos
Here we present the results of a multiple organizational level analysis conceived to identify acclimative/adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily fluctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong differences in the light environment...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210479/pregnant-after-assisted-reproduction-a-risk-pregnancy-is-born-18-years-perinatal-outcome-results-from-a-population-based-registry-in-flanders-belgium
#20
W Ombelet, G Martens, L Bruckers
BACKGROUND: Although the increased risk for perinatal morbidity and mortality of babies born after ART is largely attributed to a higher rate of multiple gestations, a significantly worse perinatal outcome for singleton pregnancies following ART compared to pregnancies after natural conception has been reported as well. Most studies only include IVF/ICSI pregnancies; studies describing the perinatal outcome of pregnancies after non-IVF assisted reproduction are scarce. METHODS AND MATERIALS: Population-based cohort study with three exposure groups: a study group of pregnancies (1) after ovarian stimulation (OS), with or without artificial insemination (AI), (2) after IFV or ICSI and (3) a naturally conceived (NC) comparison group...
December 2016: Facts, Views & Vision in ObGyn
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