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https://www.readbyqxmd.com/read/28544907/micrornas-that-affect-the-fanconi-anemia-brca-pathway-are-downregulated-in-imatinib-resistant-chronic-myeloid-leukemia-patients-without-detectable-bcr-abl-kinase-domain-mutations
#1
E Yap, Z A Norziha, A Simbun, N R Tumian, S K Cheong, C F Leong, C L Wong
Chronic myeloid leukemia (CML) patients who do not achieve landmark responses following treatment with imatinib mesylate (IM) are considered IM-resistant. Although IM-resistance can be due to BCR-ABL kinase domain (KD) mutations, many IM-resistant patients do not have detectable BCR-ABL KD mutations. MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression. To investigate the role of miRNAs in IM-resistance, we recruited 8 chronic phase CML patients with IM-resistance who tested negative for BCR-ABL KD mutations and 2 healthy normal controls...
May 18, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28544356/older-people-s-experiences-of-falling-and-perceived-risk-of-falls-in-the-community-a-narrative-synthesis-of-qualitative-research
#2
REVIEW
Siobhan Gardiner, Margaret Glogowska, Catherine Stoddart, Sarah Pendlebury, Daniel Lasserson, Debra Jackson
AIM: To examine qualitative research exploring older people's experiences of falling and the perceived risk of falling in the community. This will contribute new insights into how falling is perceived by the older community. BACKGROUND: Falls are a major problem for older people and healthcare services across the world. Accidental falls in the community are a persistent problem that is generally recognised as an intrinsic risk of ageing. This review provides a new synthesis of evidence that considers older people's perception of falls in the community as new insights are needed if the increasing problems of falls are to be addressed...
May 22, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28544113/the-role-of-water-in-catalyst-free-aldol-reaction-of-water-insoluble-n-methyl-2-4-thiazolidinedione-with-n-methyl-isatin-from-qm-mm-monte-carlo-simulation
#3
Jianming Zhao, Fen He, Fan Zhang, Xin Yang, Zhiyue Tian, Ying Xue
The role of water in the uncatalyzed aldol reaction of N-methyl-2,4-thiazolidinedione with N-methyl-isatin has been investigated using Monte Carlo statistical mechanics simulations utilizing the free-energy perturbation theory and the QM/MM model with PDDG/PM3 for the QM method under the "on water" and dimethyl sulfoxide (DMSO) environments. There are several conceivable orientations between thiazolidinedione and isatin in the process of C-C bond formation. However, the formation of C-C bond takes place between the re face of isatin and the si face of E-enol of the thiazolidinedione to form the preferred anti-type product, which results from enhancing hydrogen bonding interaction between water molecules and the oxygen atoms undergoing bond broken and bond formation during the reaction...
May 23, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28543651/the-past-present-and-future-of-mexico-s-national-bioethics-commission
#4
Manuel Ruiz de Chavez, Aidee Orozco, Gustavo Olaiz
The establishment of Mexico's National Bioethics Commission (Comisión Nacional de Bioética), in 1992, was conceived within the context of a global movement aimed at raising awareness of the ethical implications of technological and scientific development, especially in biomedicine. In 2005, a new decree put the commission under the scope of the Secretariat of Health and granted it technical and operational autonomy, allowing it to become a regulatory agency aimed at promoting a culture of bioethics, encouraging reflection on human health, and developing guidelines for health care, research, and education, through a global, secular, and democratic perspective...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28542547/determination-of-diagnostic-standards-on-saturated-soil-extracts-for-cut-roses-grown-in-greenhouses
#5
John Jairo Franco-Hermida, María Fernanda Quintero, Raúl Iskander Cabrera, José Miguel Guzman
This work comprises the theoretical determination and validation of diagnostic standards for the analysis of saturated soil extracts for cut rose flower crops (Rosa spp.) growing in the Bogota Plateau, Colombia. The data included 684 plant tissue analyses and 684 corresponding analyses of saturated soil extracts, all collected between January 2009 and June 2013. The tissue and soil samples were selected from 13 rose farms, and from cultivars grafted on the 'Natal Briar' rootstock. These concurrent samples of soil and plant tissues represented 251 production units (locations) of approximately 10,000 m2 distributed across the study area...
2017: PloS One
https://www.readbyqxmd.com/read/28541549/cognitive-development-in-children-up-to-age-11-years-born-after-art-a-longitudinal-cohort-study
#6
Anna Barbuscia, Melinda C Mills
STUDY QUESTION: How does the cognitive development of children conceived after ART (IVF and ICSI) - measured as cognitive skills at age 3, 5, 7 and 11 years - differ over time from those born after natural conception (NC)? SUMMARY ANSWER: Improved measures of cognitive development up to age 5 years were recorded in children conceived with ART compared to NC, which attenuates by 11 years, with ART children still scoring slightly better than NC children. WHAT IS KNOWN ALREADY: Results on the cognitive outcomes of children conceived after ART have been highly contradictory...
May 24, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28541418/donor-conceived-children-the-view-ahead
#7
Lauri A Pasch, Jean Benward, Joanna E Scheib, Julia T Woodward
No abstract text is available yet for this article.
May 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28541402/reply-disclosure-and-donor-conceived-children
#8
Guido Pennings
No abstract text is available yet for this article.
May 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28540783/role-of-dual-energy-computed-tomography-in-detecting-early-recurrences-of-lung-tumours-treated-with-radiofrequency-ablation
#9
Jean Izaaryene, Vincent Vidal, Jean-Michel Bartoli, Anderson Loundou, Jean-Yves Gaubert
PURPOSE: Detecting a recurrence after lung radiofrequency ablation (RFA) is based on a group of arguments that include CT, positron emission tomography (PET-CT) at 3 months and clinical patient follow-up. There is no one examination that is absolutely reliable. Recurrences are diagnosed tardily, when the cancers are locally extended, or when the patients are metastatic. The purpose of this article is to investigate the utility of dual-energy computed tomography (DECT) in order to assess therapeutic responses to RFA for lung neoplasia...
March 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540722/ultrafast-screening-and-quantitation-of-pesticides-in-food-and-environmental-matrices-by-solid-phase-microextraction-transmission-mode-spme-tm-and-direct-analysis-in-real-time-dart
#10
German Augusto Gómez-Ríos, Emanuela Gionfriddo, Justen J Poole, Janusz Pawliszyn
The direct interface of microextraction technologies to Mass Spectrometry (MS) has unquestionably revolutionized the speed and efficacy at which complex matrices are analyzed. Solid Phase Micro Extraction-Transmission Mode (SPME-TM) is a technology conceived as an effective synergy between sample preparation and ambient ionization. Succinctly, the device consists of a mesh coated with polymeric particles that extract analytes of interest present in a given sample matrix. This coated-mesh acts as a transmission mode substrate for Direct Analysis in Real Time (DART), allowing for rapid and efficient thermal-desorption/ionization of analytes previously concentrated on the coating, and dramatically lowering limits of detection attained by sole DART analysis...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28539633/ultrashort-vortex-from-a-gaussian-pulse-an-achromatic-interferometric-approach
#11
Dinesh N Naik, Nabil A Saad, D Narayana Rao, Nirmal K Viswanathan
The more than a century old Sagnac interferometer is put to first of its kind use to generate an achromatic single-charge vortex equivalent to a Laguerre-Gaussian beam possessing orbital angular momentum (OAM). The interference of counter-propagating polychromatic Gaussian beams of beam waist ωλ with correlated linear phase (ϕ 0  ≥ 0.025 λ) and lateral shear (y 0  ≥ 0.05 ωλ) in orthogonal directions is shown to create a vortex phase distribution around the null interference. Using a wavelength-tunable continuous-wave laser the entire range of visible wavelengths is shown to satisfy the condition for vortex generation to achieve a highly stable white-light vortex with excellent propagation integrity...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28538915/brazil-s-policy-on-healthcare-for-government-workers-players-paths-and-challenges
#12
Maria Inês Carsalade Martins, Simone Santos Oliveira, Elsa Thomé de Andrade, Maria Cristina Strauzz, Larisse Caroline Ferreira de Castro, Aline de Azambuja
This article aims to analyze the extent to which Brazil's public sector has made progress in institutionalizing an integral and participative model for the healthcare of government workers, based on the principles of universality, integrality and workers' participation. Based on documents produced by the Rio de Janeiro Permanent Forum on Workers' Health, the paper analyses the process of implantation of the Integrated Public Workers' Healthcare Sub-System (SIASS) in the municipality of Rio de Janeiro over the period 2009-2016, based on the historical institutionalism...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28536849/nmd-monitors-translational-fidelity-24-7
#13
REVIEW
Alper Celik, Feng He, Allan Jacobson
Nonsense-mediated mRNA decay (NMD) is generally thought to be a eukaryotic mRNA surveillance pathway tasked with the elimination of transcripts harboring an in-frame premature termination codon (PTC). As presently conceived, NMD acting in this manner minimizes the likelihood that potentially toxic polypeptide fragments would accumulate in the cytoplasm. This notion is to be contrasted to the results of systematic RNA-Seq and microarray analyses of NMD substrates in multiple model systems, two different experimental approaches which have shown that many mRNAs identified as NMD substrates fail to contain a PTC...
May 23, 2017: Current Genetics
https://www.readbyqxmd.com/read/28535841/the-epigenetic-effects-of-assisted-reproductive-technologies-ethical-considerations
#14
M-C Roy, C Dupras, V Ravitsky
The use of assisted reproductive technologies (ART) has increased significantly, allowing many coping with infertility to conceive. However, an emerging body of evidence suggests that ART could carry epigenetic risks for those conceived through the use of these technologies. In accordance with the Developmental Origins of Health and Disease hypothesis, ART could increase the risk of developing late-onset diseases through epigenetic mechanisms, as superovulation, fertilization methods and embryo culture could impair the embryo's epigenetic reprogramming...
May 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28535819/does-the-placebo-effect-modulate-drug-bioavailability-randomized-cross-over-studies-of-three-drugs
#15
Muhammad M Hammami, Ahmed Yusuf, Faduma S Shire, Rajaa Hussein, Reem Al-Swayeh
BACKGROUND: Medication effect is the sum of its drug, placebo, and drug*placebo interaction effects. It is conceivable that the interaction effect involves modulating drug bioavailability; it was previously observed that being aware of caffeine ingestion may prolong caffeine plasma half-life. This study was set to evaluate such concept using different drugs. METHODS: Balanced single-dose, two-period, two-group, cross-over design was used to compare the pharmacokinetics of oral cephalexin, ibuprofen, and paracetamol, each described by its name (overt) or as placebo (covert)...
May 23, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28535172/invited-commentary-the-framingham-offspring-study-a-pioneering-investigation-into-familial-aggregation-of-cardiovascular-risk
#16
JoAnn E Manson, Shari S Bassuk
Launched in 1948, the Framingham Heart Study was a seminal prospective cohort study of 5,209 adult residents of Framingham, Massachusetts, that was designed to uncover the determinants and natural history of coronary heart disease. Data from this original cohort established the cardiac threat posed by high blood pressure, high cholesterol, smoking, obesity, physical inactivity, diabetes, and other factors. In the late 1960s, investigators conceived the innovative idea of assembling a second cohort that comprised the adult children of the original study population (and these children's spouses)...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28534015/oncologic-and-obstetric-outcomes-of-conservative-surgery-for-borderline-ovarian-tumors-in-women-of-reproductive-age
#17
Se Yun Lee, Min Chul Choi, Bo Ram Kwon, Sang Geun Jung, Hyun Park, Won Duk Joo, Chan Lee, Je Ho Lee, Joon Mo Lee
OBJECTIVE: To compare the oncologic and obstetric outcomes in reproductive-age females with borderline ovarian tumors (BOTs) treated with cyst enucleation (CE) or unilateral salpingo-oophorectomy (USO). METHODS: The medical records of patients with BOTs treated between 1998 and 2014 were retrospectively reviewed. The recurrence rates in the USO and CE groups were compared, and the postoperative obstetric outcomes were assessed via telephone survey. RESULTS: Eighty-nine patients with BOTs underwent USO, and 19 underwent CE...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28532838/lactational-oestrus-and-reproductive-performance-following-a-delayed-limited-nursing-schedule-in-primiparous-sows
#18
REVIEW
T Y Chen, D L Turpin, A L Knight, E G Bouwman, N M Soede, R N Kirkwood, P Langendijk
With conventional lactation management, sows only conceive after weaning. However, intermittent suckling (IS) enables follicle growth and ovulation during lactation by reducing the suckling-induced inhibition of gonadotrophins. The current study evaluated IS regimes initiated at Day 21 or Day 28 post farrowing compared to conventional weaning on Day 28, in primiparous sows. Sows (Large White and Large White x Landrace) were randomly allocated to Control (C28; n = 44), IS21 (n = 29) and IS28 (n = 34) treatments at Day 20...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532740/reduced-intellectual-ability-in-offspring-of-ovarian-hyperstimulation-syndrome-a-cohort-study
#19
Gu-Feng Xu, Cheng-Liang Zhou, Yi-Meng Xiong, Jing-Yi Li, Tian-Tian Yu, Shen Tian, Xian-Hua Lin, Yun Liao, Yuan Lv, Fang-Hong Zhang, Zhi-Wei Liu, Yin-Yin Shi, Yan Shen, Jin Sha, Dan Zhang, Yi-Min Zhu, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS: We recruited 86 Chinese children born to OHSS women and 172 children conceived with non-OHSS In Vitro Fertilization (IVF) in this cohort study. Their intellectual ability was assessed according to the Revised Chinese Version of the Wechsler Intelligence Scale for Children (C-WISC)...
May 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28531319/improved-sperm-kinematics-in-semen-samples-collected-after-2-h-versus-4-7-days-of-ejaculation-abstinence
#20
H Alipour, G Van Der Horst, O B Christiansen, F Dardmeh, N Jørgensen, H I Nielsen, C Hnida
STUDY QUESTION: Does a short abstinence period of only 2 h yield spermatozoa with better motility characteristics than samples collected after 4-7 days? SUMMARY ANSWER: Despite lower semen volume, sperm concentration, total sperm counts and total motile counts, higher percentages of motile spermatozoa with higher velocity and progressiveness were detected in samples obtained after 2 h. WHAT IS KNOWN ALREADY: Most studies that have assessed the effect of abstinence periods on sperm motility parameters in men with a sperm concentration below 15 million/ml have detected a higher percentage of motile spermatozoa in samples obtained after short abstinence periods...
May 22, 2017: Human Reproduction
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