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https://www.readbyqxmd.com/read/27932705/possible-role-for-glomerular-derived-angiotensinogen-in-nephrotic-syndrome
#1
Mihoko Yamazaki, Yoshiyasu Fukusumi, Mutsumi Kayaba, Yukina Kitazawa, Sayuri Takamura, Ichiei Narita, Hiroshi Kawachi
BACKGROUND AND OBJECTIVE: Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed the glomerular expression of RAS components in nephrotic models and the effect of Ang II receptor blockers (ARB) on the expression of angiotensinogen (AGT)...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27932523/treatment-of-recurrent-ovarian-cysts-and-primary-infertility-by-iranian-traditional-medicine-a-case-report
#2
Mehdi Salehi, Mohammad Setayesh, Roshanak Mokaberinejad
Infertility is a medical and psychosocial problem with a high prevalence. There are different treatments for this problem in Iranian traditional medicine. A 28-year-old woman presented with the complaints of 4 emergency operations of the left ovarian cyst during 4 years and infertility. Diagnostic laparoscopy showed an ovarian cyst, adhesion, and endometriosis. Hysteroscopy was unremarkable. After 2 months of letrozole administration, the ovarian cyst ruptured again. Considering the failure of conventional treatments, Iranian traditional medicine products were administered to the patient...
December 8, 2016: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/27932174/salvage-splenic-artery-embolization-for-saving-falling-living-donor-graft-due-to-portal-overflow-a-case-report
#3
H Okabe, T Yoshizumi, T Ikegami, H Uchiyama, N Harimoto, S Itoh, K Kimura, H Baba, Y Maehara
Portal decompression is an approach for reducing portal overflow caused by small-for-size syndrome. We report the case of a patient who recovered from rapidly progressing hyperbilirubinemia caused by a small graft by decompressing portal overflow with splenic artery embolization following a living donor liver transplantation (LDLT). The patient was a 54-year-old man with end-stage liver disease secondary to alcoholic liver cirrhosis; the donor was his 54-year-old wife. The graft volume of the left lobe was 444 mL, which was 34...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931833/hyperglycemia-tumorigenesis-and-chronic-inflammation
#4
REVIEW
Shu-Chun Chang, Wei-Chung Vivian Yang
Hyperglycemia is the most prominent sign that characterizes diabetes. Hyperglycemia favors malignant cell growth by providing energy to cancer cells. Clinical studies also showed an increased risk of diabetes being associated with different types of cancers. In addition, poorly regulated glucose metabolism in diabetic patients is often found with increased levels of chronic inflammatory markers, e.g., interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, and emerging evidence has highlighted activation of the immune response in the progression and development of cancer cells...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27930941/evaluation-of-a-new-low-dose-levonorgestrel-intrauterine-contraceptive-system-over-5-years-of-use
#5
Kristina Gemzell-Danielsson, Dan Apter, Sylvia Dermout, Thomas Faustmann, Kimberly Rosen, Thomas Schmelter, Martin Merz, Anita Nelson
OBJECTIVE: To evaluate the efficacy and safety of a new, low-dose levonorgestrel intrauterine contraceptive system (LNG-IUS 12) for up to 5 years of use. STUDY DESIGN: In this Phase III study, 2885 nulliparous and parous women aged 18-35 years were randomized to LNG-IUS 8 or LNG-IUS 12 for 3 years. After 3 years, women using LNG-IUS 12 could continue for up to 2 additional years (5 years total). The primary outcome was occurrence of pregnancy (Pearl Index). Secondary outcomes included safety, bleeding, dysmenorrhea, discontinuations, and user satisfaction...
November 20, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27929522/merging-allylic-c-h-bond-activation-and-c-c-bond-cleavage-en-route-to-the-formation-of-a-quaternary-carbon-stereocenter-in-acyclic-systems
#6
Alexandre Vasseur, Ilan Marek
This protocol describes a diastereoselective approach for the synthesis of complex molecular architectures containing two stereogenic centers in a 1,4 relationship, one of which being an all-carbon quaternary stereogenic center. Such molecules could be intermediates in the synthesis of steroids, for example. Conceived as a single-flask synthetic sequence from ω-ene cyclopropanes, the protocol involves a concerted allylic C-H and C-C bond activation promoted by the Negishi reagent (Cp2Zr(η(2)-butene)). This zirconium-promenade-based procedure affords bifunctionalized products in high diastereomeric ratios after reaction of ω-ene cyclopropanes with the Negishi complex, followed by a thermal treatment and sequential addition of two different electrophiles...
January 2017: Nature Protocols
https://www.readbyqxmd.com/read/27929465/using-multi-fluorinated-bile-acids-and-in-vivo-magnetic-resonance-imaging-to-measure-bile-acid-transport
#7
Jessica Felton, Kunrong Cheng, Anan Said, Aaron C Shang, Su Xu, Diana Vivian, Melissa Metry, James E Polli, Jean-Pierre Raufman
Along with their traditional role as detergents that facilitate fat absorption, emerging literature indicates that bile acids are potent signaling molecules that affect multiple organs; they modulate gut motility and hormone production, and alter vascular tone, glucose metabolism, lipid metabolism, and energy utilization. Changes in fecal bile acids may alter the gut microbiome and promote colon pathology including cholerrheic diarrhea and colon cancer. Key regulators of fecal bile acid composition are the small intestinal Apical Sodium-dependent Bile Acid Transporter (ASBT) and fibroblast growth factor-19 (FGF19)...
November 27, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27927846/risk-of-postpartum-psychosis-after-ivf-treatment-a-nationwide-case-control-study
#8
Josefin Vikström, Ann Josefsson, Mats Hammar, Marie Bladh, Gunilla Sydsjö
STUDY QUESTION: Is the risk of postpartum psychosis (PPP) increased in women who give birth after IVF treatment compared to after spontaneous conception? SUMMARY ANSWER: The risk of PPP is not higher in the group of women who give birth after IVF treatment compared with women who give birth after spontaneous conception. WHAT IS KNOWN ALREADY: Women who conceive using IVF treatment can experience higher levels of pregnancy-specific distress and are at increased risk of pre-eclampsia, an immune-related condition which in turn has been linked to PPP, as well as other pregnancy and delivery complications, which also serve as PPP risk factors...
December 6, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27927843/risk-of-childhood-mortality-in-family-members-of-men-with-poor-semen-quality
#9
Heidi A Hanson, Erik N Mayer, Ross E Anderson, Kenneth I Aston, Douglas T Carrell, Justin Berger, William T Lowrance, Ken R Smith, James M Hotaling
STUDY QUESTION: What is the familial childhood mortality in first-degree (FDR) and second-degree relatives (SDR) of patients undergoing semen analysis (SA)? SUMMARY ANSWER: The relationship between infertility and congenital malformations (CM) in offspring is complex, with an increased risk of death due to CM in FDR, but not SDR, of men with lower semen parameters. WHAT IS KNOWN ALREADY: Semen quality is an established predictor of men's somatic health...
December 6, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27926501/abdominal-radical-trachelectomy-guided-by-sentinel-lymph-node-biopsy-for-stage-ib1-cervical-cancer-with-tumors-2-cm
#10
Xiangyun Deng, Ying Zhang, Dapeng Li, Xiaoling Zhang, Hui Guo, Fei Wang, Xiugui Sheng
Accuracy of prediction of pelvic lymph node status using sentinel lymph node biopsy (SLNB), and outcomes of SLNB-guided abdominal radical trachelectomy (ART) were assessed. Patients with stage IB1 (Figure 2009) cervical cancer and with tumors >2 cm were enrolled. Prior to fertility-sparing surgery 99mTc-labeled phytate was administered. SLNs were intraoperatively identified, excised, and assessed using fast-frozen sections. Systematic bilateral pelvic lymphadenectomy with or without para-aortic lymphadenectomy was subsequently undertaken...
December 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925729/curvature-induced-asymmetric-spin-wave-dispersion
#11
Jorge A Otálora, Ming Yan, Helmut Schultheiss, Riccardo Hertel, Attila Kákay
In magnonics, spin waves are conceived of as electron-charge-free information carriers. Their wave behavior has established them as the key elements to achieve low power consumption, fast operative rates, and good packaging in magnon-based computational technologies. Hence, knowing alternative ways that reveal certain properties of their undulatory motion is an important task. Here, we show using micromagnetic simulations and analytical calculations that spin-wave propagation in ferromagnetic nanotubes is fundamentally different than in thin films...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925487/a-novel-safer-conception-counseling-toolkit-for-the-prevention-of-hiv-a-mixed-methods-evaluation-in-kisumu-kenya
#12
Joelle Brown, Betty Njoroge, Eliud Akama, Brooke Breitnauer, Anna Leddy, Lynae Darbes, Richard Omondi, Okeoma Mmeje
Safer conception strategies can prevent HIV transmission between HIV-discordant partners while allowing them to conceive. However, HIV care providers in sub-Saharan Africa report they are not trained in safer conception, and patients are not routinely offered safer conception services. This mixed-methods pilot study evaluated the impact, acceptability, and feasibility of a novel Safer Conception Counseling Toolkit among providers and patients in Kenya. We enrolled 20 HIV-positive women, 10 HIV-discordant couples, and 10 providers from HIV care and treatment clinics...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27924708/has-dry-cold-weather-an-impact-on-the-skin-condition-of-cleanroom-workers
#13
Wobbeke Weistenhöfer, Wolfgang Uter, Hans Drexler
In previous epidemiological studies irritant skin changes were reported significantly more frequently under dry/cold ambient air conditions. The aim of this study was to assess whether a similar effect might be observed in cleanroom workers, occupationally exposed to strictly controlled ambient conditions. This investigation examined 690 employees of a semiconductor production company in Germany, one half in winter (n = 358) and the other half in spring (n = 332). In both waves, both cleanroom workers, who used occlusive gloves predominantly during the entire shift, and employees in the administration, serving as the control group, were included...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27924241/sleep-and-fatigue-among-seafarers-the-role-of-environmental-stressors-duration-at-sea-and-psychological-capital
#14
Sigurd W Hystad, Jarle Eid
BACKGROUND: Seafaring is an inherently stressful environment. Because working time and leisure time is spent in the same confined environment for a prolonged period of time, many stressors present in seafaring can also be conceived of as chronic. We explored the effects of duration at sea, seafaring experience, environmental stressors, and psychological capital (PsyCap) on the sleep quality and fatigue of seafarers. PsyCap is a construct that draws upon ideas from positive psychology and positive organizational behavior, and is intended to capture an individual's psychological capacities that can be developed and utilized for performance improvements...
December 2016: Safety and Health At Work
https://www.readbyqxmd.com/read/27922278/successful-treatment-of-a-severe-early-onset-case-of-pemphigoid-gestationis-with-intravenous-immunoglobulin-in-a-twin-pregnancy-conceived-with-in-vitro-fertilisation-in-a-primigravida
#15
M De la Calle, C Vidaurrázaga, N Martinez, M González-Beato, E Antolín, J L Bartha
No abstract text is available yet for this article.
December 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27921000/distress-in-infertile-males-in-manipal-india-a-clinic-based-study
#16
Ansha Patel, Podila Satya Venkata Narasimha Sharma, Pratapkumar Narayan, Binu Valsalakumari Sreekumaran Nair, Dinesh Narayanakurup, Praveena Joglekar Pai
BACKGROUND: Being infertile comes as an overwhelming realization for couples trying to conceive. In consideration of rising rates of infertility worldwide, clinicians in India have also begun exploring this field for new possibilities, development and research. The purpose of this study was to estimate the proportion and predictors of infertility specific stress in males diagnosed with primary infertility. METHODS: This cross-sectional research was conducted in an assisted reproduction center, Manipal, India, on 300 infertile married males...
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27920819/co-administration-of-metformin-and-n-acetylcysteine-with-dietary-control-improves-the-biochemical-and-histological-manifestations-in-rats-with-non-alcoholic-fatty-liver
#17
Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Fatma Abdel-Latif Ebeid
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcysteine (NAC) with dietary control on biochemical and histologic liver manifestations. Rats were classified into nine groups; normal (I), NAFLD-induced by feeding high-fat diet (HFD; II) for 12 weeks, NAFLD switched to regular diet (RD; III), NAFLD-HFD or -RD treated with MTF in a dose of 150 mg/kg (IV, V), NAC in a dose of 500 mg/kg (VI, VII) or MTF+NAC (VIII, IX) respectively for 8 weeks...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27920437/developing-a-scalable-artificial-photosynthesis-technology-through-nanomaterials-by-design
#18
Nathan S Lewis
An artificial photosynthetic system that directly produces fuels from sunlight could provide an approach to scalable energy storage and a technology for the carbon-neutral production of high-energy-density transportation fuels. A variety of designs are currently being explored to create a viable artificial photosynthetic system, and the most technologically advanced systems are based on semiconducting photoelectrodes. Here, I discuss the development of an approach that is based on an architecture, first conceived around a decade ago, that combines arrays of semiconducting microwires with flexible polymeric membranes...
December 6, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27920164/epistemic-injustice-in-healthcare-encounters-evidence-from-chronic-fatigue-syndrome
#19
Charlotte Blease, Havi Carel, Keith Geraghty
Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) remains a controversial illness category. This paper surveys the state of knowledge and attitudes about this illness and proposes that epistemic concerns about the testimonial credibility of patients can be articulated using Miranda Fricker's concept of epistemic injustice. While there is consensus within mainstream medical guidelines that there is no known cause of CFS/ME, there is continued debate about how best to conceive of CFS/ME, including disagreement about how to interpret clinical studies of treatments...
December 5, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27917558/multivariate-sexual-selection-on-male-tegmina-in-wild-populations-of-sagebrush-crickets-cyphoderris-strepitans-orthoptera-haglidae
#20
G D Ower, J Hunt, S K Sakaluk
Although the strength and form of sexual selection on song in male crickets have been studied extensively, few studies have examined selection on the morphological structures that underlie variation in males' song, particularly in wild populations. Geometric morphometric techniques were used to measure sexual selection on the shape, size and symmetry of both top and bottom tegmina in wild populations of sagebrush crickets, a species in which nuptial feeding by females imposes an unambiguous phenotypic marker on males...
November 7, 2016: Journal of Evolutionary Biology
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