Tatyana Zykova, Feng Zhu, Lei Wang, Haitao Li, Do Young Lim, Ke Yao, Eunmiri Roh, Sang-Pil Yoon, Hong-Gyum Kim, Ki Beom Bae, Weihong Wen, Seung Ho Shin, Janos Nadas, Yan Li, Weiya Ma, Ann M Bode, Zigang Dong
The biological functions of the p53-related protein kinase (PRPK) remain unclear. We have previously demonstrated that PRPK is phosphorylated by the T-LAK cell-originated protein kinase (TOPK) and that phosphorylated PRPK (p-PRPK) promotes colon cancer metastasis. Here, we analyzed colon adenocarcinomas from 87 patients and found that higher expression levels of p-PRPK were associated with later stages of metastatic dissemination (stage III and IV) as compared with earlier stages (stages I and II). Indeed, levels of p-PRPK were higher in metastatic versus malignant human colon adenocarcinomas...
May 2018: Molecular Cancer Therapeutics