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https://www.readbyqxmd.com/read/28241487/poor-vitamin-c-status-late-in-pregnancy-is-associated-with-increased-risk-of-complications-in-type-1-diabetic-women-a-cross-sectional-study
#1
Bente Juhl, Finn Friis Lauszus, Jens Lykkesfeldt
Vitamin C (vitC) is essential for normal pregnancy and fetal development and poor vitC status has been related to complications of pregnancy. We have previously shown lower vitC status in diabetic women throughout pregnancy compared to that of non-diabetic controls. Here, we evaluate the relationship between vitC status late in diabetic pregnancy in relation to fetal outcome, complications of pregnancy, diabetic characteristics, and glycemic control based on data of 47 women from the same cohort. We found a significant relationship between the maternal vitC level > or ≤ the 50% percentile of 26...
February 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28241392/the-high-incidence-of-severe-chronic-kidney-disease-after-intestinal-transplantation-and-its-impact-on-patient-and-graft-survival
#2
Geneviève Huard, Kishore Iyer, Jang Moon, John T Doucette, Vinay Nair, Thomas D Schiano
INTRODUCTION: Using data from the SRTR, cumulative incidence, risk factors for, and impact on survival of severe CKD in ITx recipients were assessed. METHODS: First-time adult ITx recipients transplanted in the United States between 01/01/1990 and 12/31/2012 were included. Severe CKD after ITx was defined as: GFR <30 ml/min/1.73m(2) , chronic hemodialysis initiation, or KTx. Survival analysis and extended Cox model were conducted. RESULTS: The cumulative incidence of severe CKD one, five and ten years after ITx was 3...
February 27, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28241376/neurophysiological-recovery-5-years-after-carpal-tunnel-release-in-patients-with-diabetes
#3
Niels O B Thomsen, Gert S Andersson, Jonas Björk, Lars B Dahlin
INTRODUCTION: The long-term results of neurophysiological recovery after carpal tunnel release in patients with diabetes have not been studied. METHODS: Thirty-five patients with diabetes and carpal tunnel syndrome (CTS) were matched with 31 patients without diabetes who had idiopathic CTS, and 27 and 30 patients, respectively participated in this follow-up study. Nerve conduction results at 5 years were compared with previously published results at baseline and 1-year...
February 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28241308/apolipoprotein-e2-and-e3-but-not-e4-promote-retinal-pathologic-neovascularization
#4
Tomomi Masuda, Masamitsu Shimazawa, Yuhei Hashimoto, Atsushi Kojima, Shinsuke Nakamura, Shinsuke Suemori, Kiyofumi Mochizuki, Hideaki Kawakami, Kazuhide Kawase, Hideaki Hara
Purpose: To determine the relationship between the different isoforms of apolipoprotein E (ApoE) and retinal neovascularization. Methods: The concentrations of ApoE and VEGF in vitreous humor samples with either a macular hole (MH), or diabetic macular edema (DME), or proliferative diabetic retinopathy (PDR) with or without intravitreal injection of bevacizumab (IVB) were measured by ELISA. The effects of each isoform of ApoE on human retinal microvascular endothelial cells (HRMECs) in culture or on the retina of oxygen-induced retinopathy (OIR) mice were investigated...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241295/review-long-term-dual-antiplatelet-therapy-dapt-after-pci-is-no-better-than-short-term-dapt-even-with-diabetes
#5
Richard G Bach
No abstract text is available yet for this article.
February 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241279/thiazolidinediones-and-advanced-liver-fibrosis-in-nonalcoholic-steatohepatitis-a-meta-analysis
#6
Giovanni Musso, Maurizio Cassader, Elena Paschetta, Roberto Gambino
Importance: Nonalcoholic steatohepatitis (NASH) is projected to be the leading cause of liver transplantation by 2020. Advanced fibrosis (stage F3-F4) on liver biopsy independently predicts all-cause and liver-related mortality in NASH. There are no known efficacious treatments for advanced fibrosis related to NASH. Thiazolidinedione therapy has been extensively evaluated in NASH, and new randomized clinical trials (RCTs) of its efficacy have been completed. Objective: To synthesize the evidence about the association of thiazolidinedione therapy with advanced liver fibrosis in NASH...
February 27, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28241208/association-between-telomere-length-and-risk-of-cancer-and-non-neoplastic-diseases-a-mendelian-randomization-study
#7
Philip C Haycock, Stephen Burgess, Aayah Nounu, Jie Zheng, George N Okoli, Jack Bowden, Kaitlin Hazel Wade, Nicholas J Timpson, David M Evans, Peter Willeit, Abraham Aviv, Tom R Gaunt, Gibran Hemani, Massimo Mangino, Hayley Patricia Ellis, Kathreena M Kurian, Karen A Pooley, Rosalind A Eeles, Jeffrey E Lee, Shenying Fang, Wei V Chen, Matthew H Law, Lisa M Bowdler, Mark M Iles, Qiong Yang, Bradford B Worrall, Hugh Stephen Markus, Rayjean J Hung, Chris I Amos, Amanda B Spurdle, Deborah J Thompson, Tracy A O'Mara, Brian Wolpin, Laufey Amundadottir, Rachael Stolzenberg-Solomon, Antonia Trichopoulou, N Charlotte Onland-Moret, Eiliv Lund, Eric J Duell, Federico Canzian, Gianluca Severi, Kim Overvad, Marc J Gunter, Rosario Tumino, Ulrika Svenson, Andre van Rij, Annette F Baas, Matthew J Bown, Nilesh J Samani, Femke N G van t'Hof, Gerard Tromp, Gregory T Jones, Helena Kuivaniemi, James R Elmore, Mattias Johansson, James Mckay, Ghislaine Scelo, Robert Carreras-Torres, Valerie Gaborieau, Paul Brennan, Paige M Bracci, Rachel E Neale, Sara H Olson, Steven Gallinger, Donghui Li, Gloria M Petersen, Harvey A Risch, Alison P Klein, Jiali Han, Christian C Abnet, Neal D Freedman, Philip R Taylor, John M Maris, Katja K Aben, Lambertus A Kiemeney, Sita H Vermeulen, John K Wiencke, Kyle M Walsh, Margaret Wrensch, Terri Rice, Clare Turnbull, Kevin Litchfield, Lavinia Paternoster, Marie Standl, Gonçalo R Abecasis, John Paul SanGiovanni, Yong Li, Vladan Mijatovic, Yadav Sapkota, Siew-Kee Low, Krina T Zondervan, Grant W Montgomery, Dale R Nyholt, David A van Heel, Karen Hunt, Dan E Arking, Foram N Ashar, Nona Sotoodehnia, Daniel Woo, Jonathan Rosand, Mary E Comeau, W Mark Brown, Edwin K Silverman, John E Hokanson, Michael H Cho, Jennie Hui, Manuel A Ferreira, Philip J Thompson, Alanna C Morrison, Janine F Felix, Nicholas L Smith, Angela M Christiano, Lynn Petukhova, Regina C Betz, Xing Fan, Xuejun Zhang, Caihong Zhu, Carl D Langefeld, Susan D Thompson, Feijie Wang, Xu Lin, David A Schwartz, Tasha Fingerlin, Jerome I Rotter, Mary Frances Cotch, Richard A Jensen, Matthias Munz, Henrik Dommisch, Arne S Schaefer, Fang Han, Hanna M Ollila, Ryan P Hillary, Omar Albagha, Stuart H Ralston, Chenjie Zeng, Wei Zheng, Xiao-Ou Shu, Andre Reis, Steffen Uebe, Ulrike Hüffmeier, Yoshiya Kawamura, Takeshi Otowa, Tsukasa Sasaki, Martin Lloyd Hibberd, Sonia Davila, Gang Xie, Katherine Siminovitch, Jin-Xin Bei, Yi-Xin Zeng, Asta Försti, Bowang Chen, Stefano Landi, Andre Franke, Annegret Fischer, David Ellinghaus, Carlos Flores, Imre Noth, Shwu-Fan Ma, Jia Nee Foo, Jianjun Liu, Jong-Won Kim, David G Cox, Olivier Delattre, Olivier Mirabeau, Christine F Skibola, Clara S Tang, Merce Garcia-Barcelo, Kai-Ping Chang, Wen-Hui Su, Yu-Sun Chang, Nicholas G Martin, Scott Gordon, Tracey D Wade, Chaeyoung Lee, Michiaki Kubo, Pei-Chieng Cha, Yusuke Nakamura, Daniel Levy, Masayuki Kimura, Shih-Jen Hwang, Steven Hunt, Tim Spector, Nicole Soranzo, Ani W Manichaikul, R Graham Barr, Bratati Kahali, Elizabeth Speliotes, Laura M Yerges-Armstrong, Ching-Yu Cheng, Jost B Jonas, Tien Yin Wong, Isabella Fogh, Kuang Lin, John F Powell, Kenneth Rice, Caroline L Relton, Richard M Martin, George Davey Smith
Importance: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. Data Sources: Genomewide association studies (GWAS) published up to January 15, 2015...
February 23, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28241076/characterisation-of-liver-fat-in-the-uk-biobank-cohort
#8
Henry R Wilman, Matt Kelly, Steve Garratt, Paul M Matthews, Matteo Milanesi, Amy Herlihy, Micheal Gyngell, Stefan Neubauer, Jimmy D Bell, Rajarshi Banerjee, E Louise Thomas
Non-alcoholic fatty liver disease and the risk of progression to steatohepatitis, cirrhosis and hepatocellular carcinoma have been identified as major public health concerns. We have demonstrated the feasibility and potential value of measuring liver fat content by magnetic resonance imaging (MRI) in a large population in this study of 4,949 participants (aged 45-73 years) in the UK Biobank imaging enhancement. Despite requirements for only a single (≤3min) scan of each subject, liver fat was able to be measured as the MRI proton density fat fraction (PDFF) with an overall success rate of 96...
2017: PloS One
https://www.readbyqxmd.com/read/28240837/liver-transplantation-for-severe-alcoholic-hepatitis-the-pro-view
#9
Michael R Lucey
Although liver transplantation has become accepted as a life-saving treatment of last resort for most life-threatening liver disorders, the use of liver transplantation to rescue patients with severe alcoholic hepatitis unresponsive to medical therapy remains controversial. I propose the concepts that alcohol use disorder is an illness, that on occasion results in alcoholic liver disease and that treatment of alcoholic liver disease, including treatment of patients with severe alcoholic hepatitis, combines treatment of the alcohol use disorder and of alcoholic liver disease...
March 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28240822/reduced-skeletal-muscle-secreted-frizzled-related-protein-3-is-associated-with-inflammation-and-insulin-resistance
#10
Alok S Pachori, Meenu Madan, Yury O Nunez Lopez, Fanchao Yi, Christian Meyer, Attila A Seyhan
OBJECTIVE: To investigate the role of secreted frizzled-related protein 3 (Sfrp3) in insulin sensitivity (ISi) and β-cell function in humans across a spectrum of glucose homeostasis. METHODS: Subjects included those with normal glucose homeostasis (NGT; n = 18), prediabetes (PD; n = 11), or type 2 diabetes (T2D; n=12). Serum and skeletal muscle (SkM) Sfrp3 levels were measured by ELISA and qPCR, respectively, and insulin signaling pathway was assessed by Western blot...
February 27, 2017: Obesity
https://www.readbyqxmd.com/read/28240799/revascularization-of-atherosclerotic-renal-artery-stenosis-for-chronic-heart-failure-versus-acute-pulmonary-oedema
#11
Darren Green, James P Ritchie, Constantina Chrysochou, Philip A Kalra
AIM: To determine whether the apparent benefit of revascularization of renal artery stenosis for "flash" pulmonary oedema extends to heart failure patients without a history of prior acute pulmonary oedema. METHODS: A prospective study of patients with renal artery stenosis and heart failure at a single centre between 1(st) January 1995 and 31(st) December 2010. Patients were divided into those with and without previous acute pulmonary oedema / decompensation. Survival analysis compared revascularization versus medical therapy in each group using Cox regression adjusted for age, eGFR, blood pressure, and co-morbidities...
February 27, 2017: Nephrology
https://www.readbyqxmd.com/read/28240701/12-year-television-viewing-time-trajectories-and-physical-function-in-older-adults
#12
Natasha Reid, Genevieve N Healy, Robin M Daly, Peter Baker, Elizabeth G Eakin, David W Dunstan, Neville Owen, Paul A Gardiner
INTRODUCTION: The purpose of this study was to identify trajectories of older adults' television viewing (TV) time over 12 years; and, to examine their associations with performance-based measures of physical function. METHODS: Data on TV time (hours/week) and socio-demographic factors were collected at each assessment of the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study (1999/2000; 2004/2005; 2011/2012), with objective measures of physical function (2...
February 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28240590/a-meta-analysis-of-avascular-necrosis-in-systemic-lupus-erythematosus-prevalence-and-risk-factors
#13
Tatiana Nevskaya, Maeve P Gamble, Janet E Pope
OBJECTIVES: To determine the prevalence of and risk factors for avascular necrosis (AVN) in systemic lupus erythematosus (SLE). METHODS: MEDLINE, CINAHL, Web of Science, EMBASE and Cochrane Library were searched from inception to July, 2015 and a random effects model was used to combine frequencies; study quality was assessed using STROBE. RESULTS: 2,041 citations identified 62 articles. Many results had high heterogeneity. The prevalence of symptomatic AVN was 9% (range 0...
February 24, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28240525/infrapopliteal-calcification-patterns-in-critical-limb-ischemia-diagnostic-pathologic-and-therapeutic-implications-in-the-search-for-the-endovascular-holy-grail
#14
Jihad A Mustapha, Larry J Diaz-Sandoval, Fadi Saab
Critical limb ischemia (CLI) represents the terminal stage of peripheral arterial disease (PAD) and is characterized by multilevel and multivessel disease. Amongst patients with infrainguinal disease, approximately one third have predominantly isolated infrapopliteal disease and the remaining two thirds, a combination of femoropopliteal and infrapopliteal disease. Isolated infrapopliteal disease is mainly seen in the elderly, diabetic, or dialysis-dependent patients. These patients have higher risk of amputation and shorter amputation-free survival...
February 27, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28240446/sodium-glucose-cotransporter-2-inhibitors-and-risk-of-adverse-renal-outcomes-among-type-2-diabetes-patients-a-network-and-cumulative-meta-analysis-of-randomized-controlled-trials
#15
Huilin Tang, Dandan Li, Jingjing Zhang, Yufeng Li, Tiansheng Wang, Suodi Zhai, Yiqing Song
AIM: The renal safety of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) remains uncertain. This meta-analysis aimed to compare the effects of each SGLT2 inhibitor on adverse renal outcomes in patients with T2DM. METHODS: PubMed, EMBASE, CENTRAL, and ClinicalTrials.gov were searched up to May 24 2016 without language or date restrictions. Randomized trials that reporting at least one renal-related adverse outcome in T2DM patients treated with SGLT2 inhibitors were included...
February 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28240395/financial-remuneration-is-positively-correlated-with-the-number-of-clinical-activities-an-example-from-diabetes-management-in-alberta-community-pharmacies
#16
Rajan Bharadia, Kathleen Lorenz, Ken Cor, Scot H Simpson
OBJECTIVE: To determine whether use of a compensation plan to remunerate pharmacists for clinical pharmacy services was associated with the number of diabetes management activities provided. METHODS: Alberta pharmacists were asked about compensation plan use and frequency they provide a list of 80 diabetes management activities. KEY FINDINGS: A total of 168 community pharmacists responded to the survey. When compensation plan use, diabetes-specific training, practice characteristics and additional authorizations were incorporated into a factorial ANOVA, pharmacists who used the compensation plan reported a mean of 42...
February 27, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28240390/a-novel-dimorphic-pathogen-emergomyces-orientalis-onygenales-agent-of-disseminated-infection
#17
Peng Wang, Chris Kenyon, Sybren de Hoog, Lina Guo, Hongwei Fan, Hongrui Liu, Zhongwei Li, Ruiyuan Sheng, Ying Yang, Yanping Jiang, Li Zhang, Yingchun Xu
A novel dimorphic fungus, Emergomyces orientalis sp. nov. a close relative of systemic pathogens in the family Ajellomycetaceae (Blastomyces, Histoplasma). The fungus is reported in a 64-year-old male from Shanxi, China. The patient developed disseminated skin lesions, productive cough with fever and showed nodular opacities in his left lung on chest radiography. The patient had no identified cause of immunodeficiency apart from type-2 diabetes mellitus. Clinical, histopathological and mycological characteristics of the agent are given, and its phylogenetic position is determined with multilocus sequence data...
February 27, 2017: Mycoses
https://www.readbyqxmd.com/read/28240378/coronary-artery-calcification-and-cognitive-function-cross-sectional-results-from-the-elsa-brasil-study
#18
Claudia K Suemoto, Marcio S Bittencourt, Itamar S Santos, Isabela M Benseñor, Paulo A Lotufo
OBJECTIVES: We examined the relationship between coronary artery calcification (CAC) score and performance in cognitive tests in a large Brazilian sample. METHODS: In this cross-sectional study, 4104 participants (mean age = 50.9 ± 8.8 years old, 54% female) from the Brazilian Longitudinal Study of Adult Health had complete information for CAC and cognitive tests. We used linear regression models adjusted for sociodemographics, cardiovascular risk factors (hypertension, diabetes, smoking, alcohol use, physical activity, and body mass index), depression, and thyroid function...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28240341/factors-influencing-cardiometabolic-risk-profile-in-patients-with-psoriasis
#19
Neus Curcó, Nuria Barriendos, Maria José Barahona, Carmen Arteaga, Mercedes García, Stanislav Yordanov, Olimpia De La Barrera, Carolina Prat, Pere Vives, Nuria Giménez
BACKGROUND: Psoriasis has been associated with metabolic syndrome and with an increased cardiovascular risk especially in patients with severe disease. The goal of this study was to estimate the prevalence of metabolic syndrome and other cardiovascular risk factors and its association with the psoriasis severity, sex and age. METHODS: Consecutive patients with psoriasis were enrolled in a prospective study over a 1-year period. Blood samples were collected. Psoriasis area and severity index (PASI) and body surface area scores and two dermatology quality of life (DQOL) questionnaires were used to evaluate psoriasis severity and the impact of the disease...
February 27, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28240316/p53-induces-mir199a-3p-to-suppress-socs7-for-stat3-activation-and-renal-fibrosis-in-uuo
#20
Ruhao Yang, Xuan Xu, Huiling Li, Jinwen Chen, Xudong Xiang, Zheng Dong, Dongshan Zhang
The role of p53 in renal fibrosis has recently been suggested, however, its function remains controversial and the underlying mechanism is unclear. Here, we show that pharmacological and genetic blockade of p53 attenuated renal interstitial fibrosis, apoptosis, and inflammation in mice with unilateral urethral obstruction (UUO). Interestingly, p53 blockade was associated with the suppression of miR-215-5p, miR-199a-5p&3p, and STAT3. In cultured human kidney tubular epithelial cells (HK-2), TGF-β1 treatment induced fibrotic changes, including collagen I and vimentin expression, being associated with p53 accumulation, p53 Ser15 phosphorylation, and miR-199a-3p expression...
February 27, 2017: Scientific Reports
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