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https://www.readbyqxmd.com/read/28208818/hydroxycinnamic-acids-and-their-derivatives-cosmeceutical-significance-challenges-and-future-perspectives-a-review
#1
Oludemi Taofiq, Ana M González-Paramás, Maria Filomena Barreiro, Isabel C F R Ferreira
Bioactive compounds from natural sources, due to their widely-recognized benefits, have been exploited as cosmeceutical ingredients. Among them, phenolic acids emerge with a very interesting potential. In this context, this review analyzes hydroxycinnamic acids and their derivatives as multifunctional ingredients for topical application, as well as the limitations associated with their use in cosmetic formulations. Hydroxycinnamic acids and their derivatives display antioxidant, anti-collagenase, anti-inflammatory, antimicrobial and anti-tyrosinase activities, as well as ultraviolet (UV) protective effects, suggesting that they can be exploited as anti-aging and anti-inflammatory agents, preservatives and hyperpigmentation-correcting ingredients...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28123310/cosmeceutical-product-consisting-of-biomimetic-peptides-antiaging-effects-in-vivo-and-in-vitro
#2
Zarema I Gazitaeva, Anna O Drobintseva, Yongji Chung, Victoria O Polyakova, Igor M Kvetnoy
BACKGROUND: Biomimetic peptides are synthetic compounds that are identical to amino acid sequence synthesized by an organism and can interact with growth factor receptors and provide antiaging clinical effects. PURPOSE: The purpose of this study was to investigate the effects of biomimetic peptides on the repair processes in the dermis using a model of cell cultures and in vivo. PATIENTS AND METHODS: Five female volunteers were subjected to the injection of biomimetic peptides 1 month prior to the abdominoplasty procedure...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28117410/the-green-microalga-tetraselmis-suecica-reduces-oxidative-stress-and-induces-repairing-mechanisms-in-human-cells
#3
Clementina Sansone, Christian Galasso, Ida Orefice, Genoveffa Nuzzo, Elvira Luongo, Adele Cutignano, Giovanna Romano, Christophe Brunet, Angelo Fontana, Francesco Esposito, Adrianna Ianora
Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28095530/the-anti-aging-effects-of-low-oxygen-tension-generated-multipotent-growth-factor-containing-serum
#4
Zoe Diana Draelos, Jwala Karnik, Gail Naughton
Growth factors are a new category of ingredient found in modern cosmeceutical formulations. One novel method of obtaining cosmeceutical growth factors is the use of a bioreactor to culture neonatal broblasts on dextran microcarrier beads for 8 weeks under low oxygen tension (1-5%) mimicking embryonic conditions and eliminating the need for fetal bovine serum constituents in the final cosmetic material. This research evaluated the ingredient in a moisturizing vehicle on 40 females to determine its efficacy in improving overall facial skin appearance, as well as skin brightness, evenness, firmness, pore size, radiance, fine lines, coarse wrinkles, and blotchiness/ dispigmentation...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28063095/the-use-of-cosmeceuticals-in-acne-help-or-hoax
#5
Brittany S Barros, Andrea L Zaenglein
The use of cosmeceuticals by patients with acne is common; however, their role is unclear and confusing, with many asking, "Do they really help acne?" Cosmeceuticals are intermediate products between prescription medications and cosmetics, available to consumers over the counter. These products are popular and may be used without the direct supervision of a dermatologist, creating a practice gap in educating patients. Herein, a variety of cosmeceuticals are discussed, including retinoids, niacinamide, and glycolic acid...
January 6, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27987920/is-molecular-size-a-discriminating-factor-in-hyaluronan-interaction-with-human-cells
#6
Antonella D'Agostino, Antonietta Stellavato, Luisana Corsuto, Paola Diana, Rosanna Filosa, Annalisa La Gatta, Mario De Rosa, Chiara Schiraldi
Nowadays there is a great interest in investigating the effect of particular hyaluronan fragments in the biomedical field and in cosmeceutical applications. Literature has reported that very low molecular weight HA (Mw<5kDa) has an inflammatory effect, whilst HA ranging from 15 to 250 has shown controversial effects. This work aims to give better elucidation on the correlation between the different sized HA fragments and their biological functions. In this respect, a simple and effective degradation strategy is used to obtain several HA fragments...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27978790/recent-trends-in-nanotechnology-based-drugs-and-formulations-for-targeted-therapeutic-delivery
#7
Hafiz M N Iqbal, Angel Villalba, Rekha Khandia, Ashok Munjal, Kuldeep Dhama
In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applications is essential and also a core demand to tackle many human health related diseases...
December 13, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27918006/cosmeceuticals-in-skin-of-color
#8
Leslie Baumann
Patients with skin of color have similar skin care needs as lighter-skin patients. However, they are less likely to use sun protection on a daily basis, which leads to an increased risk of dyschromia, skin cancer, and other disorders. This article discusses the importance of a correct and consistent skin care regimen and the various cutaneous issues that should be considered when prescribing a skin care regimen for patients with darker skin types. Adopting a standardized methodology to identify affordable, efficacious products and to streamline the process of skin-type diagnosis, skin care regimen prescribing, patient communication, and staff education will result in improved patient outcomes and increased patient satisfaction...
December 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27914965/a-review-on-synthesis-properties-and-applications-of-natural-polymer-based-carrageenan-blends-and-composites
#9
REVIEW
Khalid Mahmood Zia, Shazia Tabasum, Muhammad Nasif, Neelam Sultan, Nosheen Aslam, Aqdas Noreen, Mohammad Zuber
Carrageenan is a natural polysaccharide extracted from edible red seaweeds of Rhodophycea class. It has been used as a viscosity increasing or gelling agent for prolonged and controlled drug release, food, pharmaceuticals and other industries. However, in spite of wide range of applications, carrageenan has some drawbacks and adverse effects on the biological systems, so its modifications with natural and synthetic polymers are carried out. This review article presents different sources and properties of carrageenans with special emphasis on natural polymer based carrageenan blends and composites and their applications in controlled drug delivery system, wound dressing and tissue engineering because of their biodegradability and biocompatibility, food industry as thickening/gelling materials, cosmeceuticals and making polyelectrolyte complexes...
November 30, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27865609/recent-advances-in-lipid-based-vesicles-and-particulate-carriers-for-topical-and-transdermal-application
#10
REVIEW
Shashank Jain, Niketkumar Patel, Mansi K Shah, Pinak Khatri, Namrata Vora
In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery, and interest in life cycle management strategies among pharmaceutical companies. Literature review of recent publications indicates that among various skin delivery systems, lipid-based delivery systems (vesicular carriers and lipid particulate systems) have been the most successful. Vesicular carriers consist of liposomes, ultradeformable liposomes, and ethosomes, while lipid particulate systems consist of lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers...
February 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27859298/experimental-and-theoretical-study-of-the-influence-of-water-on-hydrolyzed-product-formation-during-the-feruloylation-of-vegetable-oil
#11
David L Compton, Kervin O Evans, Michael Appell
BACKGROUND: Feruloylated vegetable oil is a valuable green bioproduct that has several cosmeceutical applications associated with its inherent anti-oxidant and ultraviolet-absorption properties. Hydrolyzed vegetable oil by-products can influence product quality and consistency. RESULTS: The formation of by-products by residual water in the enzymatic synthesis of feruloylated vegetable oil was investigated using chemical theory and experimental studies by monitoring the reaction over a 22-day period...
November 18, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27842483/patents-on-therapeutic-and-cosmetic-applications-of-bioactives-of-crocus-sativus-l-and-their-production-through-synthetic-biology-methods-a-review
#12
Mitali Nitin Dawalbhakta, Manasi Alok Telang
BACKGROUND: Saffron (Crocus sativus L.) has a long history of use as a food additive and a traditional medicine for treating a number of disorders. Prominent bioactives of saffron are crocin, crocetin and safranal. OBJECTIVE: The aim of this study was to carry out an extensive patent search to collect information on saffron bioactives and their derivatives as therapeutic and cosmeceutical agents. All patents related to the area of interest published globally till date have been reviewed...
November 14, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27775594/extracellular-metabolites-from-industrial-microalgae-and-their-biotechnological-potential
#13
REVIEW
Lu Liu, Georg Pohnert, Dong Wei
Industrial microalgae, as a big family of promising producers of renewable biomass feedstock, have been commercially exploited for functional food, living feed and feed additives, high-value chemicals in nutraceuticals, cosmeceuticals, and chemical reagents. Recently, microalgae have also been considered as a group that might play an important role in biofuel development and environmental protection. Almost all current products of industrial microalgae are derived from their biomass; however, large amounts of spent cell-free media are available from mass cultivation that is mostly unexploited...
October 20, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27754433/development-of-mushroom-based-cosmeceutical-formulations-with-anti-inflammatory-anti-tyrosinase-antioxidant-and-antibacterial-properties
#14
Oludemi Taofiq, Sandrina A Heleno, Ricardo C Calhelha, Maria José Alves, Lillian Barros, Maria Filomena Barreiro, Ana M González-Paramás, Isabel C F R Ferreira
The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is still slow progress in the biotechnological application of mushroom extracts in cosmetic formulations, either as antioxidants, anti-aging, antimicrobial, and anti-inflammatory agents or as hyperpigmentation correctors...
October 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27697492/blends-and-composites-of-exopolysaccharides-properties-and-applications-a-review
#15
REVIEW
Abid Hussain, Khalid Mahmood Zia, Shazia Tabasum, Aqdas Noreen, Muhammad Ali, Rehana Iqbal, Mohammad Zuber
Exopolysaccharides are synthesized by bacteria and secreted into the external environment and they may be homopolymeric or heteropolymeric in configuration. They are believed to protect bacterial cells from heavy metals, desiccation or other environmental effect. EPS exhibit antitumor, anti-HIV, emulsion stabilization capacity, shear-thinning activity, suspension ability, high viscosities, excellent biocompatibility, high biodegradability and immunomodulatory properties. They are widely used in herbicides, functional food, nutraceuticals, cosmeceuticals, pharmaceuticals, insecticides, immunomodulation and anticoagulants...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27673445/physical-and-biological-characterization-of-sericin-loaded-copolymer-liposomes-stabilized-by-polyvinyl-alcohol
#16
Kunat Suktham, Thongchai Koobkokkruad, Somsak Saesoo, Nattika Saengkrit, Suvimol Surassmo
Sericin protein (SP) is widely used as a nutrient biomaterial for biomedical and cosmeceutical applications although it shows low stability to heat and light. To overcome these problems and add value to wastewater from the silk industry, sericin protein was recovered as sericin-loaded copolymer-liposomes (SP-PVA-LP), prepared through thin film hydration. The size and morphology of the liposomes were investigated using dynamic light scattering (DLS), and electron microscopy (SEM and TEM). The particle size, liposome surface morphology and encapsulation efficiency of SP were dependent on PVA concentration...
December 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27621603/chum-salmon-egg-extracts-induce-upregulation-of-collagen-type-i-and-exert-antioxidative-effects-on-human-dermal-fibroblast-cultures
#17
Atsushi Yoshino, Natalia Polouliakh, Akira Meguro, Masaki Takeuchi, Tatsukata Kawagoe, Nobuhisa Mizuki
Components of fish roe possess antioxidant and antiaging activities, making them potentially very beneficial natural resources. Here, we investigated chum salmon eggs (CSEs) as a source of active ingredients, including vitamins, unsaturated fatty acids, and proteins. We incubated human dermal fibroblast cultures for 48 hours with high and low concentrations of CSE extracts and analyzed changes in gene expression. Cells treated with CSE extract showed concentration-dependent upregulation of collagen type I genes and of multiple antioxidative genes, including OXR1, TXNRD1, and PRDX family genes...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27570454/eupafolin-nanoparticles-protect-hacat-keratinocytes-from-particulate-matter-induced-inflammation-and-oxidative-stress
#18
Zih-Chan Lin, Chiang-Wen Lee, Ming-Horng Tsai, Horng-Huey Ko, Jia-You Fang, Yao-Chang Chiang, Chan-Jung Liang, Lee-Fen Hsu, Stephen Chu-Sung Hu, Feng-Lin Yen
Exposure to particulate matter (PM), a major form of air pollution, can induce oxidative stress and inflammation and may lead to many diseases in various organ systems including the skin. Eupafolin, a flavonoid compound derived from Phyla nodiflora, has been previously shown to exhibit various pharmacological activities, including antioxidant and anti-inflammatory effects. Unfortunately, eupafolin is characterized by poor water solubility and skin penetration, which limits its clinical applications. To address these issues, we successfully synthesized a eupafolin nanoparticle delivery system (ENDS)...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27530764/micro-needling-depth-penetration-presence-of-pigment-particles-and-fluorescein-stained-platelets-clinical-usage-for-aesthetic-concerns
#19
Gordon H Sasaki
BACKGROUND: Aesthetic micro-needling (MN) has demonstrated skin permeability to cosmeceutical ingredients and platelet-rich plasma by creating reversible micro-channels in the skin. OBJECTIVES: The purposes of this study were to determine: (1) actual needle depth-penetrations by adjusting needle lengths in a disposable tip of an electric MN device; (2) time-dependent passage of pigment and platelets; and (3) safety and efficacy profiles in patients. METHODS: Excised micro-needled pre-auricular skin was used to determine actual depths of tissue penetration with six needle lengths, and the presence of massaged pigment particles (histological examination) and fluorescein-labeled platelets (confocal laser microscopy) in 1 mm depth micro-channels over an hour...
January 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27527190/acetylated-triterpene-glycosides-and-their-biological-activity-from-holothuroidea-reported-in-the-past-six-decades
#20
REVIEW
Yadollah Bahrami, Christopher M M Franco
Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumbers are triterpene glycosides (saponins). Due to the wide range of their potential biological activities, these natural compounds have gained attention and this has led to their emergence as high value compounds with extended application in nutraceutical, cosmeceutical, medicinal and pharmaceutical products...
August 4, 2016: Marine Drugs
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