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Khurul Ain Mohamed Mahzir, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi
In this study, the optimal conditions for the extraction of antioxidants from the Buah Mahkota Dewa fruit ( Phaleria macrocarpa) was determined by using Response Surface Methodology (RSM). The optimisation was applied using a Central Composite Design (CCD) to investigate the effect of three independent variables, namely extraction temperature (°C), extraction time (minutes) and extraction solvent to-feed ratio (% v / v ) on four responses: free radical scavenging activity (DPPH), ferric ion reducing power assay (FRAP), total phenolic content (TPC) and total flavonoid content (TFC)...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Silvia Revoltella, Giorgia Baraldo, Birgit Waltenberger, Stefan Schwaiger, Philipp Kofler, Julia Moesslacher, Astrid Huber-Seidel, Konrad Pagitz, Roland Kohl, Pidder Jansen-Duerr, Hermann Stuppner
NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable source for the identification of novel bioactive natural products with anti-ageing effects, especially substances that protect plants against UV radiation, which is also known to contribute to the ageing of human skin. Therefore, the aim of this study was to identify novel Nox4 inhibitors from alpine plants...
March 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jongmi Lim, Chae Jin Lim, Sungwoo Kim, Gaewon Nam, Minyoul Chang, Keedon Park, Kyungho Park, Hyun Jung Kim, Jeong Keun Ahn, Sekyoo Jeong
BACKGROUND: Recently, potential roles of autophagy in skin homeostasis received many interests. But, little has been reported for the potential antiaging effects of autophagy activator. OBJECTIVE: With the newly synthesized autophagy activator, heptasodium hexacarboxymethyl dipeptide-12 (Aquatide™) in vitro and clinical efficacy of the topical autophagy activator as an antiaging cosmeceutical ingredient was evaluated. METHODS: Antioxidant effect of Aquatide™ was evaluated by radical scavenging assay...
March 9, 2018: Journal of Cosmetic Dermatology
Mpofana Nomakhosi, Abrahamse Heidi
A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. This pigment is responsible for skin, hair, and eye color, therefore determines our race and phenotypic appearance. On darker skin types, it is common that melanin production processes malfunctions. These malfunctions often lead to overproduction and secretion of melanin. As a result, unwanted pigmentary problems such melasma occur...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Shymaa Hatem, Maha Nasr, Seham A Elkheshen, Ahmed S Geneidi
Antioxidants are among the most important cosmeceuticals, with proven ability of inhibiting cellular damage. The topical skin administration of antioxidants is essential for minimizing skin aging and achieving better skin protection against harmful free radicals. However, their unfavorable physiochemical properties such as chemical instability, excessive hydrophilicity or lipophilicity and others could be a great obstacle against their skin promising effects as well as their delivery to deeper skin layers. These problems could all be remedied through the use of delivery carriers...
February 14, 2018: Current Drug Delivery
Sidharth Sonthalia, Abhijeet K Jha, Aimilios Lallas, Geraldine Jain, Deepak Jakhar
The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a "wonder" drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the unbridled and prodigal use of it, especially as a parenteral formulation, seems unjustified, given the lacunae in our knowledge about its antimelanogenic potential, limited clinical evidence favoring its role in skin lightening, and the statutory ban/advisory issued by certain federal agencies...
January 2018: Dermatology Practical & Conceptual
Inhyuk Yeo, Yong-Jik Lee, Kyeongseop Song, Hyeon-Su Jin, Jae-Eun Lee, Dajeong Kim, Dong-Woo Lee, Nam Joo Kang
Bioactive peptides contribute to various cellular processes including improved skin physiology. Hence, bioactive keratins have attracted considerable attention as active cosmetic ingredients for skin health. Here, we obtained low molecular weight (LMW) keratins from native chicken feathers by anaerobic digestion with an extremely thermophilic bacterium Fervidobacterium islandicum AW-1, followed by stepwise fractionation through ultrafiltration. To assess the effects of the feather keratins on skin health, we performed in vitro and ex vivo assays to investigate their inhibitory effects on matrix metalloproteinases (MMPs)...
February 10, 2018: Journal of Biotechnology
Babar Iqbal, Javed Ali, Sanjula Baboota
Skin is the largest and easily accessible organ of the body. Increases in incidences of dermatological disorders, demand for drug targeting, and patient compliance have increased the popularity of topical drug delivery amongst the people. However, drug delivery across the skin is still a challenge for researchers because permeation of maximum drugs is hindered by the upper layer of the epidermis (stratum corneum). Several approaches like use of chemical permeation enhancers and physical methods such as sonophoresis, iontophoresis, electroporation, microneedles, etc...
February 12, 2018: International Journal of Dermatology
Yu-Jin Oh, Mi-Sun Kwak, Kwang Kim, Moon-Hee Sung
Poly-gamma-glutamate (γ-PGA), an anionic polymer of glutamic acid bonded by γ-amide linkages, is a very promising biodegradable polymer isolated from the Bacillus subtilis sp. Chungkookjang found in Korean fermented food. γ-PGA is useful in a wide range of industrial fields, such as food, cosmetics, and medicine as it is water-soluble, anionic, biodegradable, and edible. In this study, we compared the radioprotective effects of high-molecular-weight 3,000 kDa γ-PGA and reduced form of glutathione (GSH known as radioprotector) on DNA damage...
February 1, 2018: Journal of Microbiology and Biotechnology
Ranga Rao Ambati, Deepika Gogisetty, Ravishankar Gokare Aswathanarayana, Sarada Ravi, Panduranga Narasimharao Bikkina, Lei Bo, Su Yuepeng
Microalgae are rich source of various bioactive molecules such as carotenoids, lipids, fatty acids, hydrocarbons, proteins, carbohydrates, amino acids, etc. and in recent year's carotenoids from algae gained commercial recognition in the global market for food and cosmeceutical applications. However, the production of carotenoids from algae is not yet fully cost effective to compete with synthetic ones. In this context the present review examines the technologies/methods in relation to mass production of algae, cell harvesting for extraction of carotenoids, optimizing extraction methods etc...
January 25, 2018: Critical Reviews in Food Science and Nutrition
Margit Lw Juhász, Melissa K Levin, Ellen S Marmur
BACKGROUND: The cosmeceutical industry is an ever-growing and in demand market, especially in Asia. Korea has been on the forefront of creating the newest generation and most innovative cosmeceuticals products including ingredients such as snail secretions, starfish powder, botanical extracts, green tea, and red ginseng. Given their increasing prevalence in the cosmeceutical industry, scientists have been conducting investigations into these extracts and their properties. OBJECTIVE: To summarize the current literature surrounding multiple natural ingredients found in Korean cosmeceutical products...
January 24, 2018: Journal of Cosmetic Dermatology
Yo Han Hong, Donghyun Kim, Gibaeg Nam, Sulgi Yoo, Sang Yun Han, Seong-Gu Jeong, Eunji Kim, Deok Jeong, Keejung Yoon, Sunggyu Kim, Junseong Park, Jae Youl Cho
Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry...
January 2018: Journal of Ginseng Research
Maha F Abdel-Ghany, Miriam F Ayad, Neven N Mikawy
Synchronous spectrofluorimetric methods could be successfully adopted for simultaneous determination of Octinoxate (OMC), Avobenzone (AVO), Octyltriazone (OT), and Phenyl benzimidazole sulfonic acid (PBSA) in moisturizing sunscreen lotion, utilizing β-CD as fluorescence enhancer, and determination of Avobenzone (AVO), Homosalate, Tinosorb M and Phenyl benzimidazole sulfonic acid (PBSA) in presence of Octocrylene (OCR) in whitening sunscreen cream, using micellar medium of Sodium Dodecyl Sulfate (SDS) to enhance fluorescence intensity...
January 17, 2018: Journal of Fluorescence
Maria Papaioanou, Evangelia Chronopoulou, Gheorghii Ciobotari, Rodica Efrose, Liliana Sfichi-Duke, Marianna Chatzikonstantinou, Evangelia Pappa, Ioannis Ganopoulos, Panagiotis Madesis, Irini Nianiou-Obeidat, Taofen Zeng, Nikolaos E Labrou
BACKGROUND: The starting point for the development of new, functional products derived from Rubus fruticosus L. is to determine the optimal cultivation conditions that produce maximal yield of fruits containing desirable bioactive properties. Towards that goal, the effect of soil, soil/peat mixture and light intensity on the nutraceutical and cosmeceutical potential of two cultivars ('Thornfree' and 'Loch Ness') of Rubus fruticosus L. were evaluated. 'Thornfree' cultivar produced fruits in all light conditions, while 'Loch Ness' did not produce fruits in low light conditions...
December 26, 2017: Current Pharmaceutical Biotechnology
Christian Galasso, Cinzia Corinaldesi, Clementina Sansone
As is the case for terrestrial organisms, carotenoids represent the most common group of pigments in marine environments. They are generally biosynthesized by all autotrophic marine organisms, such as bacteria and archaea, algae and fungi. Some heterotrophic organisms also contain carotenoids probably accumulated from food or partly modified through metabolic reactions. These natural pigments are divided into two chemical classes: carotenes (such as lycopene and α- and β-carotene) that are composed of hydrogen and carbon; xanthophylls (such as astaxanthin, fucoxanthin and lutein), which are constituted by hydrogen, carbon and oxygen...
November 23, 2017: Antioxidants (Basel, Switzerland)
Maria Domenica Di Mauro, Barbara Tomasello, Roberta Carla Giardina, Sandro Dattilo, Veronica Mazzei, Fulvia Sinatra, Massimo Caruso, Nicola D'Antona, Marcella Renis
Nowadays, agro-food by-products represent a potential low-cost source of biologically active ingredients which have been paid significant attention as nutraceuticals, medicine, food and cosmetics. In a previous study we evaluated the total sugars, metals and polyphenols of olive mill wastewater (OMWW) from a Cerasuola olive cultivar. In the present work we selectively recovered a sugar and mineral enriched fraction (SMEF) from Cerasuola OMWW by a green adsorption/desorption process. The SMEF was mainly found to be composed of monosaccharides and potassium by HPLC-ELSD and ICP-MS...
December 13, 2017: Food & Function
Isabela T Jones, Isabella Guiha, Sabrina G Fabi
BACKGROUND: The visible signs of photodamage can be improved by intense pulsed light (IPL). Active ingredients in cosmeceuticals also have effects on skin quality and pigmentation, and can camouflage post-treatment side effects. Combination therapies utilizing different treatment modalities have been shown to optimize clinical outcomes for skin rejuvenation and patient satisfaction. AIM: To evaluate the efficacy of a combination of IPL with a daily topical skincare and sunscreen regimen for the treatment of facial photodamage and for the improvement of IPL treatment tolerability...
November 21, 2017: Journal of Cosmetic Dermatology
Woo-Young Seo, Jeong-Ho Kim, Du-San Baek, Su-Jung Kim, Sujin Kang, Won Suk Yang, Ji-Ae Song, Moo-Seung Lee, Sunghoon Kim, Yong-Sung Kim
Procollagen type I carboxy-terminal propeptide (PICP), derived from type I procollagen, has been identified as an indicator of type I collagen synthesis in bone matrix formation and skin recovery. PICP is a heterotrimeric glycoprotein consisting of two α1 chains (PICPα1) and one α2 chain (PICPα2). Here, we report the recombinant expression of human PICP using a mammalian expression system. Co-expression of PICPα1 and PICPα2 in HEK293F cells resulted in the production of functional PICP in the correctly assembled heterotrimeric form...
November 21, 2017: Scientific Reports
Nafiseh Pakravan, Elaheh Mahmoudi, Seyed-Ali Hashemi, Jamal Kamali, Reza Hajiaghayi, Mitra Rahimzadeh, Vajiheh Mahmoodi
BACKGROUND/PURPOSE: Natural ingredients have been always an interesting approach to prolong youthful appearance of skin. One of the natural compounds is Kombucha tea (KT), which has been mainly used as an energy drink in Asian countries for a long time. Previous reports indicated that it has pharmaceutical and favorable wound repairing effects. The beneficial properties of KT are thought to be mainly due to the presence of fermentation products such as flavonoids and other polyphenols with inhibition of hydrolytic and oxidative enzymes and anti-inflammatory effects...
November 19, 2017: Journal of Cosmetic Dermatology
H Jill Feetham, H Sam Jeong, Jacqueline McKesey, Heather Wickless, Heidi Jacobe
INTRODUCTION: Patients often seek skin care recommendations from their dermatologist. The objective of this study was to determine the degree of education dermatology residents receive on skin care and cosmeceutical products, the source of education, and the attitude of trainees and their educators toward skin care and cosmeceuticals. METHODS: A cross-sectional survey of dermatology residents and faculty via an online survey administered June 2015 and August 2015, respectively...
November 19, 2017: Journal of Cosmetic Dermatology
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