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https://www.readbyqxmd.com/read/29774540/conservative-thickness-layers-in-mohs-micrographic-surgery
#1
Stanislav N Tolkachjov, Jonathan A Cappel, Elizabeth A Bryant, Christopher B Harmon
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors' aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique may be most useful. METHODS: We performed a retrospective chart review of patients with tumors treated with CTL in MMS of 339 tumors, recording patient demographics, tumor characteristics, MMS stages for clearance, repairs, complications, and follow-up...
May 17, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29773959/conservation-systematics-of-the-shield-backed-trapdoor-spiders-of-the-nigrum-group-mygalomorphae-idiopidae-idiosoma-integrative-taxonomy-reveals-a-diverse-and-threatened-fauna-from-south-western-australia
#2
Michael G Rix, Joel A Huey, Steven J B Cooper, Andrew D Austin, Mark S Harvey
The aganippine shield-backed trapdoor spiders of the monophyletic nigrum -group of Idiosoma Ausserer s. l. are revised, and 15 new species are described from Western Australia and the Eyre Peninsula of South Australia: I. arenaceum Rix & Harvey, sp. n. , I. corrugatum Rix & Harvey, sp. n. , I. clypeatum Rix & Harvey, sp. n. , I. dandaragan Rix & Harvey, sp. n. , I. formosum Rix & Harvey, sp. n. , I. gardneri Rix & Harvey, sp. n. , I. gutharuka Rix & Harvey, sp. n. , I. incomptum Rix & Harvey, sp...
2018: ZooKeys
https://www.readbyqxmd.com/read/29771376/rna-dna-and-dna-dna-base-pairing-at-the-upstream-edge-of-the-transcription-bubble-regulate-translocation-of-rna-polymerase-and-transcription-rate
#3
Maria KIreeva, Cyndi Trang, Gayane Matevosyan, Joshua Turek-Herman, Vitaly Chasov, Lucyna Lubkowska, Mikhail Kashlev
Translocation of RNA polymerase (RNAP) along DNA may be rate-limiting for transcription elongation. The Brownian ratchet model posits that RNAP rapidly translocates back and forth until the post-translocated state is stabilized by NTP binding. An alternative model suggests that RNAP translocation is slow and poorly reversible. To distinguish between these two models, we take advantage of an observation that pyrophosphorolysis rates directly correlate with the abundance of the pre-translocated fraction. Pyrophosphorolysis by RNAP stabilized in the pre-translocated state by bacteriophage HK022 protein Nun was used as a reference point to determine the pre-translocated fraction in the absence of Nun...
May 16, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29765785/spondylocostal-dysostosis-a-literature-review-and-case-report-with-long-term-follow-up-of-a-conservatively-managed-patient
#4
Brendan R Southam, Adam P Schumaier, Alvin H Crawford
Introduction: Patients with spondylocostal dysostosis (SCD) have congenital spine and rib deformities associated with frequently severe thoracic insufficiency and respiratory compromise. The literature is largely composed of case reports and small cohorts, and there is little information regarding adults with this condition. In this report, we describe the natural history of a conservatively treated patient and include quality-of-life issues such as childbearing, athletic participation, and occupational selection...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29764827/not-so-mass-effect-finding-of-a-remarkable-incidentaloma-in-a-teenager-with-neurofibromatosis
#5
Daniel John Keen, Hannah Norman-Bruce, Salah Mansy
A 13-year-old boy with neurofibromatosis type 1 presented to the emergency department twice in a fortnight with moderate intermittent abdominal pain, radiating to the back and associated with nausea and vomiting. He examined as a well child with a soft abdomen and minimal tenderness. A history of constipation was identified but he failed to respond to a trial of laxatives. Subsequent ultrasound abdomen demonstrated a large mass surrounding the porta hepatis. MRI further characterised a focal, non-aggressive lesion extending from his liver, encapsulating his pancreas, portal vessels and laterally displacing his spleen and left kidney...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29764819/penetrating-trauma-causing-cerebrospinal-fluid-leak-without-nerve-root-damage
#6
Holly Carpenter, Katherine-Helen Hurndall, Ajay K Asokan, Roland Fernandes
A 19-year-old man with a stab injury to the lower back presented with no focal neurology or haemodynamic instability. He complained of a headache that was improved by lying flat and underwent imaging to look for damage to local structures. He was found to have air in his intraspinal space. Initially this case was managed conservatively; however, 2 weeks after discharge, he presented with cerebrospinal fluid leak from his wound. This was managed with neurosurgical intervention and watertight closure of fascia...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29764781/eaono-position-statement-on-vestibular-schwannoma-imaging-assessment-question-how-should-growth-of-vestibular-schwannoma-be-defined
#7
Romain Kania, Benjamin Vérillaud, Domitille Camous, Charlotte Hautefort, Thomas Somers, Jérôme Waterval, Sébastien Froelich, Philippe Herman
The relevance of defining the growth of vestibular schwannoma (VS) is that any significant VS growth may impact treatment strategy. A conservative treatment strategy is often proposed as a primary treatment option in the management of VS. Several authors have demonstrated that a significant proportion of VSs do not grow, and those that do, usually grow slowly. Surgical and/or radiosurgical treatment options may be offered to the patient according to the VS growth. Therefore, defining the VS growth is a determinant in managing treatment strategies...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29761026/conservative-management-of-nivolumab-induced-pericardial-effusion-a-case-report-and-review-of-literature
#8
Shagufta Shaheen, Hamid Mirshahidi, Gayathri Nagaraj, Chung-Tsen Hsueh
Background: Nivolumab is an immune checkpoint inhibitor targeting programmed death-1 protein and has been approved for the treatment of multiple advanced malignancies. Adverse effects of immune checkpoint inhibitors are distinct from conventional cytotoxic chemotherapy and can be life-threatening if left unrecognized. Here, we present a case of nivolumab-induced pericardial effusion successfully managed with high-dose corticosteroids. Case presentation: A 70-year-old Caucasian female with a history of 50-pack-year cigarette smoking was diagnosed of recurrent adenocarcinoma of lung after initial surgery...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29757227/combining-fog-computing-with-sensor-mote-machine-learning-for-industrial-iot
#9
Mehrzad Lavassani, Stefan Forsström, Ulf Jennehag, Tingting Zhang
Digitalization is a global trend becoming ever more important to our connected and sustainable society. This trend also affects industry where the Industrial Internet of Things is an important part, and there is a need to conserve spectrum as well as energy when communicating data to a fog or cloud back-end system. In this paper we investigate the benefits of fog computing by proposing a novel distributed learning model on the sensor device and simulating the data stream in the fog, instead of transmitting all raw sensor values to the cloud back-end...
May 12, 2018: Sensors
https://www.readbyqxmd.com/read/29754410/hi-tech-restoration-by-two-steps-biocleaning-process-of-triumph-of-death-fresco-at-the-camposanto-monumental-cemetery-pisa-italy
#10
Giancarlo Ranalli, Elisabetta Zanardini, Alessia Andreotti, Maria Perla Colombini, Cristina Corti, Pilar Bosch-Roig, Paola De Nuntiis, Giuseppe Lustrato, Paolo Mandrioli, Laura Rampazzi, Carlo Giantomassi, Donatella Zari
AIMS: In this work, the "hi-tech" complex biocleaning and restoration of the 14th-century fresco Triumph of Death (5.6x15.0 m) at the Camposanto Monumental Cemetery (Pisa, Italy) is reported. Since 2000, the restoration based on the biological cleaning of noble medieval frescoes, has been successfully utilized in this site. METHODS AND RESULTS: The novelty of this study is the 2-steps biocleaning process using Pseudomonas stutzeri A29 viable cells, previously applied for recovering other valuable frescoes...
May 13, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29748715/restoration-of-an-academic-historical-gross-pathology-collection-refreshed-impact-on-current-medical-teaching
#11
Philip Eichhorn, Udo Andraschke, Fritz Dross, Carol I Geppert, Arndt Hartmann, Tilman T Rau
The declaration of Leiden pronounces the demand to conserve pathological-anatomical collections as cultural heritage. Likewise, the Institute of Pathology of the Friedrich-Alexander-University Erlangen-Nuremberg owns macroscopic pathological-anatomical specimens reaching back over 150 years. The purpose of this work is to examine the impact, meaning, and perception of such historical preparations during the current medical curriculum. Additionally, the experiences from the renovation process can be used as a template for other institutes...
May 10, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29746670/dicer-cleaves-5-extended-microrna-precursors-originating-from-rna-polymerase-ii-transcription-start-sites
#12
Peike Sheng, Christopher Fields, Kelsey Aadland, Tianqi Wei, Oralia Kolaczkowski, Tongjun Gu, Bryan Kolaczkowski, Mingyi Xie
MicroRNAs (miRNAs) are approximately 22 nucleotide (nt) long and play important roles in post-transcriptional regulation in both plants and animals. In animals, precursor (pre-) miRNAs are ∼70 nt hairpins produced by Drosha cleavage of long primary (pri-) miRNAs in the nucleus. Exportin-5 (XPO5) transports pre-miRNAs into the cytoplasm for Dicer processing. Alternatively, pre-miRNAs containing a 5' 7-methylguanine (m7G-) cap can be generated independently of Drosha and XPO5. Here we identify a class of m7G-capped pre-miRNAs with 5' extensions up to 39 nt long...
May 9, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29740610/improved-de-novo-genomic-assembly-for-the-domestic-donkey
#13
Gabriel Renaud, Bent Petersen, Andaine Seguin-Orlando, Mads Frost Bertelsen, Andrew Waller, Richard Newton, Romain Paillot, Neil Bryant, Mark Vaudin, Pablo Librado, Ludovic Orlando
Donkeys and horses share a common ancestor dating back to about 4 million years ago. Although a high-quality genome assembly at the chromosomal level is available for the horse, current assemblies available for the donkey are limited to moderately sized scaffolds. The absence of a better-quality assembly for the donkey has hampered studies involving the characterization of patterns of genetic variation at the genome-wide scale. These range from the application of genomic tools to selective breeding and conservation to the more fundamental characterization of the genomic loci underlying speciation and domestication...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29735526/defects-in-the-neuroendocrine-axis-contribute-to-global-development-delay-in-a-drosophila-model-of-ngly1-deficiency
#14
Tamy Portillo Rodriguez, Joshua D Mast, Tom Hartl, Tom Lee, Peter Sand, Ethan O Perlstein
N-glycanase 1 (NGLY1) Deficiency is a rare monogenic multi-system disorder first described in 2014. NGLY1 is evolutionarily conserved in model organisms. Here we conducted a natural history study and chemical-modifier screen on the Drosophila melanogaster NGLY1 homolog, Pngl. We generated a new fly model of NGLY1 Deficiency, engineered with a nonsense mutation in Pngl at codon 420 that results in a truncation of the C-terminal carbohydrate-binding PAW domain. Homozygous mutant animals exhibit global development delay, pupal lethality and small body size as adults...
May 7, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29729526/characterization-of-twin-cysteine-motif-in-the-v2-loop-region-of-gp120-in-primate-lentiviruses
#15
Dane Bowder, Jesse Thompson, Kate Durst, Haley Hollingsead, Duoyi Hu, Wenzhong Wei, Shi-Hua Xiang
The twin-cysteine motif (TCM) in the V2 loop region of gp120, identified in our previous report on the simian immunodeficiency virus mac239 (SIVmac239), is a conserved evolutionary element in all primate lentiviruses except for HIV-1 which has lost the TCM during cross-species transmission. In this study, we have further explored the TCM in other SIV and HIV-2 strains. Our data shows that strains from different evolutionary lineages have different phenotypes when the twin-cysteines are removed. In the SIVsm/HIV-2 lineage, removal of the twin-cysteines decreases envelope trimer stability, but in the SIVagm lineage, a blockage of gp160 processing is observed...
May 2, 2018: Virology
https://www.readbyqxmd.com/read/29713722/magnetic-field-effects-on-coenzyme-b-12-and-b-6-dependent-lysine-5-6-aminomutase-switching-of-the-j-resonance-through-a-kinetically-competent-radical-pair-intermediate
#16
Jun-Ru Chen, Shyue-Chu Ke
The environmental magnetic field is beneficial to migratory bird navigation through the radical-pair mechanism. One of the continuing challenges in understanding how magnetic fields may perturb biological processes is that only a very few field-sensitive examples have been explored despite the prevalence of radical pairs in enzymatic reactions. We show that the reaction of adenosylcobalamin- and pyridoxal-5'-phosphate-dependent lysine 5,6-aminomutase proceeds via radical-pair intermediates and is magnetic field dependent...
May 1, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29704687/clinical-experience-of-autologous-blood-transfusion-in-neurosurgery-prospective-study-in-central-india
#17
Harshad Patil, Deepa Navakar, Laxmikant Banabokade, Nitin Garg
OBJECTIVE: The purpose of this study was to evaluate the benefits of intraoperative autologous blood transfusion in intracranial procedures and to conserve precious homologous blood due to shortage of donor and associated complications. METHODS: This was a prospective study performed at Bansal hospital, Bhopal. Predetermined autologous blood was collected in a well labelled bag containing citrate phosphate dextrose adenine (CPDA) solution after induction of general anaesthesia...
April 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29698078/outcomes-of-conservatively-managed-coracoid-fractures-in-wild-birds-in-the-united-kingdom
#18
Jonathan M Cracknell, Alistair M Lawrie, Lisa Yon, Jane S Hopper, Yolanda Martinez Pereira, Eve Smaller, Romain Pizzi
Coracoid fractures are a frequent presentation in wild birds, commonly caused by collisions with motor vehicles, windows, or other obstacles such as pylons. Despite this, there are few reports of outcomes, and those published consist of small numbers of birds with conflicting results when comparing conservative management with surgical intervention. To determine outcome success of conservative management in a larger population of wild birds, records of 232 adult wild birds in the United Kingdom (UK) with closed unilateral coracoid fractures confirmed on radiography and surviving more than 48 hours after admission were retrospectively analyzed...
March 2018: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29687768/diagnostics-and-antibiotic-therapy-for-spondylodiscitis
#19
Franka Lestin-Bernstein, Marc Tietke, Lutz Briedigkeit, Oliver Heese
PURPOSE: Spondylodiscitis as a rare disease has increased in recent years; there are only a few recommendations regarding the diagnostics and treatment. The objective of this retrospective study was to characterise these patients and identify factors for a favourable healing process - with an emphasis on antibiotic therapy. METHODOLOGY: Findings/treatment regimens for all patients with spondylodiscitis treated at a tertiary care hospital in 2012/2013 were recorded...
April 23, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29684923/percutaneous-endoscopic-interlaminar-unilateral-ventral-dural-approach-for-symptomatic-bilateral-l5-s1-herniated-nucleus-pulposus-technical-note
#20
Sung Ho Choi, Nitin Maruti Adsul, Hyeun Sung Kim, Ki Joon Kim, Jeong Hoon Kim, Sung Kyun Chung, Jeong Hoon Choi, Jee Soo Jang, Il Tae Jang, Seong Hoon Oh
BACKGROUND:  Percutaneous endoscopic lumbar diskectomy is a good treatment modality for lumbar disk herniation. However, when a patient complains of bilateral lower limb radicular pain with severe disk protrusion at the L5-S1 level, the transforaminal approach is often unable to resolve both lesions owing to anatomical limitations. It is also very difficult to resolve both lesions in an ipsilateral direction using the percutaneous interlaminar approach. We report our surgical technique and clinical results using a ventral dural approach of percutaneous endoscopic interlaminar lumbar diskectomy for L5-S1 herniated nucleus pulposus (HNP) in patients with bilateral radiculopathy due to a severe disk protrusion...
April 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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