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https://www.readbyqxmd.com/read/28811514/differential-epitope-recognition-in-the-immunodominant-staphylococcal-antigen-a-of-staphylococcus-aureus-by-mouse-versus-human-igg-antibodies
#1
Dennis G A M Koedijk, Francisco Romero Pastrana, Hedzer Hoekstra, Sanne van den Berg, Jaap Willem Back, Carolien Kerstholt, Rianne C Prins, Irma A J M Bakker-Woudenberg, Jan Maarten van Dijl, Girbe Buist
The immunodominant staphylococcal antigen A (IsaA) is a potential target for active or passive immunization against the important human pathogen Staphylococcus aureus. Consistent with this view, monoclonal antibodies against IsaA were previously shown to be protective against S. aureus infections in mouse models. Further, patients with the genetic blistering disease epidermolysis bullosa (EB) displayed high IsaA-specific IgG levels that could potentially be protective. Yet, mice actively immunized with IsaA were not protected against S...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808654/genome-wide-identification-and-transcriptional-expression-analysis-of-cucumber-superoxide-dismutase-sod-family-in-response-to-various-abiotic-stresses
#2
Yong Zhou, Lifang Hu, Hao Wu, Lunwei Jiang, Shiqiang Liu
Superoxide dismutase (SOD) proteins are widely present in the plant kingdom and play important roles in different biological processes. However, little is known about the SOD genes in cucumber. In this study, night SOD genes were identified from cucumber (Cucumis sativus) using bioinformatics-based methods, including 5 Cu/ZnSODs, 3 FeSODs, and 1 MnSOD. Gene structure and motif analysis indicated that most of the SOD genes have relatively conserved exon/intron arrangement and motif composition. Phylogenetic analyses with SODs from cucumber and several other species revealed that these SOD proteins can be traced back to two ancestral SODs before the divergence of monocot and dicot plants...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28808326/the-importance-of-the-nutritive-value-of-old-bones-in-the-diet-of-bearded-vultures-gypaetus-barbatus
#3
Antoni Margalida, Daniel Villalba
Vultures are central-place foragers and need to optimize their foraging behaviour to offset travel costs by increasing their energy gain. This process is more obvious in certain vulture species that do not feed their young by regurgitation and so must carry food items back to the nest. The Bearded Vulture Gypaetus barbatus is the only species with a bone-diet based. We analysed the chemical composition of bones and the age-related changes in their nutritive value to assess the differences in energy content between bones of differing age, body part and species...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807894/advances-in-the-diagnosis-and-management-of-neck-pain
#4
REVIEW
Steven P Cohen, W Michael Hooten
Neck pain imposes a considerable personal and socioeconomic burden-it is one of the top five chronic pain conditions in terms of prevalence and years lost to disability-yet it receives a fraction of the research funding given to low back pain. Although most acute episodes resolve spontaneously, more than a third of affected people still have low grade symptoms or recurrences more than one year later, with genetics and psychosocial factors being risk factors for persistence. Nearly half of people with chronic neck pain have mixed neuropathic-nociceptive symptoms or predominantly neuropathic symptoms...
August 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28804900/phylogenetic-evidence-from-freshwater-crayfishes-that-cave-adaptation-is-not-an-evolutionary-dead-end
#5
David B Stern, Jesse Breinholt, Carlos Pedraza, Marilú López-Mejía, Christopher L Owen, Heather Bracken-Grissom, James W Fetzner, Keith A Crandall
Caves are perceived as isolated, extreme habitats with a set of uniquely specialized biota, which long ago led to the idea that caves are 'evolutionary dead-ends.' This suggests that cave-adapted taxa may be doomed for extinction before they can diversify or transition to a more stable state. However, this hypothesis has not been explicitly tested in a phylogenetic framework with multiple independent cave-dwelling groups. Here we use the freshwater crayfish, a group with dozens of cave-dwelling species in multiple lineages, as a system to test this hypothesis...
August 14, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28791779/crystal-structure-of-the-xpo1p-nuclear-export-complex-bound-to-the-sxfg-pxfg-repeats-of-the-nucleoporin-nup42p
#6
Masako Koyama, Hidemi Hirano, Natsuki Shirai, Yoshiyuki Matsuura
Xpo1p (yeast CRM1) is the major nuclear export receptor that carries a plethora of proteins and ribonucleoproteins from the nucleus to cytoplasm. The passage of the Xpo1p nuclear export complex through nuclear pore complexes (NPCs) is facilitated by interactions with nucleoporins (Nups) containing extensive repeats of phenylalanine-glycine (so-called FG repeats), although the precise role of each Nup in the nuclear export reaction remains incompletely understood. Here we report structural and biochemical characterization of the interactions between the Xpo1p nuclear export complex and the FG repeats of Nup42p, a nucleoporin localized at the cytoplasmic face of yeast NPCs and has characteristic SxFG/PxFG sequence repeat motif...
August 8, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28770511/dynamic-brace-is-a-good-option-to-treat-first-anterior-shoulder-dislocation-in-season
#7
M Conti, R Garofalo, A Castagna, G Massazza, E Ceccarelli
PURPOSE: We evaluate the ability of in-season competitive athletes to return to competition after an anterior shoulder instability treated conservatively with a new dynamic brace combined with a specific rehabilitation program. METHODS: Twenty soccer players affected by traumatic anterior shoulder dislocation have been enrolled in the "Footballer In Season Fast Rehab" project during 2 consecutive football seasons. We excluded patients affected by rotator cuff tears and the bony defect over 25%...
August 2, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28760999/exploiting-conformational-plasticity-in-the-aaa-protein-vcp-p97-to-modify-function
#8
Anne Kathrin Schütz, Enrico Rennella, Lewis E Kay
p97/VCP, a member of the AAA+ (ATPases associated with diverse cellular activities) family of proteins, is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue as well as the central nervous system. Methyl-TROSY-based NMR studies have previously revealed how disease-causing mutations deregulate a subtle dynamic conformational equilibrium involving the N-terminal domain (NTD) with implications for the binding of certain adaptors, providing insight into how disease mutations lead to abnormal function...
July 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28754240/resolution-of-the-enigmatic-phylogenetic-relationship-of-the-critically-endangered-western-swamp-tortoise-pseudemydura-umbrina-pleurodira-chelidae-using-a-complete-mitochondrial-genome
#9
Xiuwen Zhang, Peter J Unmack, Gerald Kuchling, Yinan Wang, Arthur Georges
Pseudemydura umbrina is one of the most endangered turtle species in the world, and the imperative for its conservation is its distinctive morphology and relict status among the Chelidae. We use Illumina sequencing to obtain the complete mitogenome for resolving its uncertain phylogenetic position. A novel nuclear paralogue confounded the assembly, and resolution of the authentic mitogenome required further Sanger sequencing. The P. umbrina mitogenome is 16,414bp comprising 37 genes organized in a conserved pattern for other vertebrates...
July 25, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28750870/-impact-of-obesity-in-the-pathophysiology-of-degenerative-disk-disease-and-in-the-morbidity-and-outcome-of-lumbar-spine-surgery
#10
Pedro David Delgado-López, José Manuel Castilla-Díez
Obesity (BMI>30Kg/m(2)) is a pandemic with severe medical and financial implications. There is growing evidence that relates certain metabolic processes within the adipose tissue, preferentially abdominal fat, with a low-intensity chronic inflammatory state mediated by adipokines and other substances that favor disk disease and chronic low back pain. Obesity greatly conditions both the preoperative evaluation and the spinal surgical technique itself. Some meta-analyses have confirmed an increase of complications following lumbar spine surgery (mainly infections and venous thrombosis) in obese subjects...
July 24, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28749848/a-rare-eyeball-luxation-after-cranioplasty-and-a-four-year-follow-up
#11
Lin Yin, Zhiyong Zhang, Wei Liu, Xiaojun Tang, Hongyu Yin, Shi Feng
A rare patient of reducible eyeball luxation after cranioplasty in a child Crouzon syndrome was reported. To remedy the patient's chronic intracranial hypertension and brachycephaly, orbitofrontal advancement and cranial vault remodeling were carried out. About 25 days of postoperation, an acute eyeball luxation was observed, with the presence of a subcutaneous accumulation of liquid in the bilateral temporal regions. The dislocated eyeballs were brought back by applying gentle manual pressure. The patient received a conservative treatment without a tarsorrhaphy...
July 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28746764/de-extinction-and-taking-control-of-earth-s-metabolism
#12
Christopher J Preston
In a laboratory on a university campus in Santa Cruz, California, Ben Novak is doing everything he can to bring Ectopistes migratorius back from the dead. Using techniques now available in genome reading and gene synthesis, he and paleogenomicist Beth Shapiro hope that, by 2032, a flock of passenger pigeons ten thousand or more strong will have resumed an ecologically significant role in the mast forests of the Eastern United States. Novak knows-and the International Union for Conservation of Nature (IUCN) affirms-that the challenges involved in making de-extinction work are far from solely genetic...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28743583/development-of-a-taqman-based-real-time-pcr-assay-for-the-specific-detection-of-porcine-circovirus-3
#13
Jianchang Wang, Yongning Zhang, Jinfeng Wang, Libing Liu, Xiaoyu Pang, Wanzhe Yuan
Porcine circovirus 3 (PCV3) is a novel circovirus that was associated with porcine dermatitis and nephropathy syndrome, reproductive failure, and multisystemic inflammation. The objective of this study was to develop a rapid, simple, specific and sensitive TaqMan-based real-time PCR assay for PCV3 detection. Specific primers and probe were designed for the cap gene of PCV3 within the conserved region of viral genome. The assay was highly specific for PCV3, without cross-reactions with other non-targeted pig viruses...
July 23, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28740935/effects-of-vertebral-body-sparing-proton-craniospinal-irradiation-on-the-spine-of-young-pediatric-patients-with-medulloblastoma
#14
Iain MacEwan, Brian Chou, Jeremy Moretz, Lilia Loredo, David Bush, Jerry D Slater
PURPOSE: To investigate the long-term effects of vertebral-body-sparing proton craniospinal irradiation (CSI) on the spine of young patients with medulloblastoma. METHODS AND MATERIALS: Six children between the ages of 3 and 5 years with medulloblastoma were treated with vertebral-body-sparing proton CSI after maximal safe resection. Radiation therapy was delivered in the supine position with posterior beams targeting the craniospinal axis, and the proton beam was stopped anterior to the thecal sac...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28739516/endopelvic-approach-for-iliac-crest-bone-harvesting-technical-note
#15
S Le Pape, R Gauthe, L Du Pouget, O Gille, J-M Vital, M Ould-Slimane
BACKGROUND: The anterior approach to lumbar spine surgery has grown in popularity in the past few years; spinal fusion of the last two lumbar levels is often required. While there are alternatives to bone grafting available, including recombinant human bone morphogenetic protein 2 or bone substitutes, only cancellous autologous bone has all the required factors for bone growth. To avoid the use of bone substitutes, remote iliac crest bone harvesting remains the gold standard. However, this technique may lead to some unfavorable outcomes...
July 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28732034/neglecting-the-call-of-the-wild-captive-frogs-like-the-sound-of-their-own-voice
#16
Luiza Figueiredo Passos, Gerardo Garcia, Robert John Young
Acoustic communication is highly influential in the expression of social behavior by anuran amphibians, transmitting information about the individual's physical condition and motivation. We studied the phonotactic (approach movements) responses of wild and captive male golden mantella frogs to conspecific wild and captive playback calls to determine the impact of captivity on social behaviour mediated by vocalisations. Calls were recorded from one wild and two captive populations. Phonotaxis experiments were then conducted by attracting M...
2017: PloS One
https://www.readbyqxmd.com/read/28727922/considerations-in-physical-therapy-management-of-a-non-responding-patient-with-low-back-pain
#17
Timothy J Madson
STUDY DESIGN: Case Study. BACKGROUND AND PURPOSE: Low back pain is a common condition managed by physical therapists (PT). Screening tools have been developed to assist the PT with medical screening of patients for serious disease. Sinister pathologies may present as musculoskeletal symptoms during the patient examination. It is important for the PT to frequently reevaluate their patient's response to therapeutic interventions and refer for further evaluation if they are not responding to conservative care...
July 20, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28721319/combined-sacroplasty-and-iliosacral-fixation-using-triangular-titanium-implants-for-the-treatment-of-sacral-insufficiency-fractures-with-concomitant-sacral-instability
#18
Ryan Johnson, Jason Seibly
Sacral insufficiency fractures (SIFs) are a common, under-recognized cause of debilitating low back pain, particularly in elderly patients with osteoporotic bone disease or risk factors for bone demineralization. Conservative therapy has been the mainstay of treatment for these types of fractures. This places patients at increased risk for the development of secondary illnesses associated with prolonged immobility, which might prevent a full return to the preinjury level of function. Surgical intervention for SIFs has increased over the past two decades in an attempt to overcome these complications and improve patient functionality...
June 14, 2017: Curēus
https://www.readbyqxmd.com/read/28720993/inserting-pedicle-screws-in-lumbar-spondylolisthesis-the-easy-bone-conserving-way
#19
Hitesh Lal, Lalit Kumar, Ramesh Kumar, Tankeshwar Boruah, Pankaj Kumar Jindal, Vinod Kumar Sabharwal
BACKGROUND: Pedicle screw fixation in high grade lumbar listhetic vertebral body has been nightmare for Orthopaedic and spine surgeons. This is because of abnormally positioned listhetic pedicles and non-visualization of pedicle in conventional image intensifier (C-Arm). This results into increased surgical time, more blood loss, radiation exposure and more chances of infection. To overcome this problem, we have devised a new Technique of putting of pedicle screw fixation in listhetic vertebrae...
April 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28718273/3d-quantitative-evaluation-of-spine-proprioceptive-perception-motor-control-through-instinctive-self-correction-manoeuvre-in-healthy-young-subjects-posture-an-observational-study
#20
Moreno D'Amico, Edyta Kinel, Piero Roncoletta
BACKGROUND: Conservative treatment in spine deformities and spine related disorders is mainly based on proper individual proprioceptive and motor control training. For these reasons, conservative treatment involves the stimulation of individual capability of perceiving/reducing deformities, blocks and/or improper spine posture by voluntary control. The literature describes that habitually adopted relaxed postures often exacerbate low back pain. Typically, youths can be referred to therapeutic programs aimed at improving the quality of body posture along with fostering the awareness of the importance of correct posture...
July 18, 2017: European Journal of Physical and Rehabilitation Medicine
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