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https://www.readbyqxmd.com/read/27908650/musculoskeletal-conditions-in-a-pediatric-population-with-ehlers-danlos-syndrome
#1
Courtney M Stern, Michael J Pepin, Joan M Stoler, Dennis E Kramer, Samantha A Spencer, Cynthia J Stein
OBJECTIVE: To describe musculoskeletal conditions in children with Ehlers-Danlos syndrome (EDS). STUDY DESIGN: A retrospective medical record review was performed, which evaluated 205 patients with EDS (ages 6-19 years) seen in sports medicine or orthopedic clinic at a large pediatric hospital over a 5-year period. RESULTS: Female (n = 147) and male (n = 57) patients were identified (mean age 12.7 years). The most common EDS subtype (55...
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27901017/daily-intake-and-hazard-index-of-parabens-based-upon-24%C3%A2-h-urine-samples-of-the-german-environmental-specimen-bank-from-1995-to-2012
#2
Rebecca K Moos, Petra Apel, Christa Schröter-Kermani, Marike Kolossa-Gehring, Thomas Brüning, Holger M Koch
In recent years, exposure to parabens has become more of a concern because of evidence of ubiquitous exposure in the general population, combined with evidence of their potency as endocrine disruptors. New human metabolism data from oral exposure experiments enable us to back calculate daily paraben intakes from urinary paraben levels. We report daily intakes (DIs) for six parabens based on 660 24 h urine samples from the German Environmental Specimen Bank collected between 1995 and 2012. Median DI values ranged between 1...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27900506/arabidopsis-thaliana-methionine-sulfoxide-reductase-b8-influences-stress-induced-cell-death-and-effector-triggered-immunity
#3
Shweta Roy, Ashis Kumar Nandi
Reactive oxygen species (ROS) oxidize methionine to methionine sulfoxide (MetSO) and thereby inactivate proteins. Methionine sulfoxide reductase (MSR) enzyme converts MetSO back to the reduced form and thereby detoxifies the effect of ROS. Our results show that Arabidopsis thaliana MSR enzyme coding gene MSRB8 is required for effector-triggered immunity and containment of stress-induced cell death in Arabidopsis. Plants activate pattern-triggered immunity (PTI), a basal defense, upon recognition of evolutionary conserved molecular patterns present in the pathogens...
November 29, 2016: Plant Molecular Biology
https://www.readbyqxmd.com/read/27891040/inadvertent-injection-of-potassium-chloride-instead-of-sodium-chloride-during-treatment-of-chronic-low-back-ache-with-epidural-injection-leading-to-paraplegia
#4
Rahul Ranjan, Naiyer Asif, Sohail Ahmad, Syed Ifthekar
Epidural injection of steroid is given for back pain resistant to other conservative management. Normal saline (NS) is used as diluent in 80 mg methylprednisolone and a local anesthetic. Due to a similar looking ampoule of NS and potassium chloride (KCl), there is a probability of accidental use of KCl instead of NS. We present a case of a 50-year-old male patient having low back ache refractory to other conservative treatments. Epidural injection of steroid was given, but accidently KCl was mixed with methylprednisolone instead of NS...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27891031/spinal-compression-fractures-due-to-pregnancy-associated-osteoporosis
#5
R Krishnakumar, Arun T Kumar, Mathew John Kuzhimattam
OBJECTIVES: To report on unique cases of spinal compression fractures due to pregnancy-associated osteoporosis (PAO) and to suggest a satisfactory treatment modality. MATERIALS AND METHODS: A single-center retrospective study. We reviewed the data of 535 patients with osteoporotic spinal compression fractures over a period of 5-year. Two patients who developed spinal compression fractures due to PAO were identified and treated. RESULTS: The clinical presentation and blood investigations ruled out other causes of osteoporosis...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27883939/is-enhanced-biodiversity-protection-conflicting-with-ambitious-bioenergy-targets-in-eastern-finland
#6
Michael den Herder, Mikko Kurttila, Pekka Leskinen, Marcus Lindner, Anniina Haatanen, Susanna Sironen, Olli Salminen, Veera Juusti, Anne Holma
The study describes how qualitative stakeholder feedback can be used in quantitative scenarios to simulate forest resource use under alternative management objectives. In earlier studies in the region of eastern Finland, stakeholders did not see a possible conflict between increased bioenergy use and nature conservation; this finding is contrary to the results of other studies. The aim of this study was to test with a quantitative modelling approach whether the stakeholder expectation holds and whether forest management in eastern Finland can simultaneously increase biomass utilization and biodiversity protection...
November 21, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27882767/-traumatic-symphyseal-rupture-by-vaginal-delivery-report-of-a-rare-case
#7
J Hofierková
OBJECTIVE: This case report draw attention symphysis pubic dysfunction and injury pelvic girdle by vaginal delivary (in our case compliated by dystokia shoulders), mainly its diagnostic, prediction and treatment. DESIGN: Case report. SETTING: Department of Obstetrics and Gynecology. Hospital Česká Lípa. CASE REPORT: We report a case of a 31 years old woman, who gave birth for the second time with rupture of symphysis after delivery...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27880071/interplay-of-cis-and-trans-regulatory-mechanisms-in-the-spliceosomal-rna-helicase-brr2
#8
Eva Absmeier, Christian Becke, Jan Wollenhaupt, Karine F Santos, Markus C Wahl
RNA helicase Brr2 is implicated in multiple phases of pre-mRNA splicing and thus requires tight regulation. Brr2 can be auto-inhibited via a large N-terminal region folding back onto its helicase core and auto-activated by a catalytically inactive C-terminal helicase cassette. Furthermore, it can be regulated in trans by the Jab1 domain of the Prp8 protein, which can inhibit Brr2 by intermittently inserting a C-terminal tail in the enzyme's RNA-binding tunnel or activate the helicase after removal of this tail...
November 23, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27866425/the-role-of-physical-status-versus-mental-status-in-predicting-the-quality-of-life-of-patients-with-lumbar-disk-herniation
#9
Batya Engel-Yeger, Amit Keren, Yaron Berkovich, Elad Sarfaty, Lior Merom
PURPOSE: To explore the role of physical status versus mental status in predicting the quality of life (QOL) of patients with lumbar disk herniation (LDH). METHOD: In this correlative study 51 patients with LDH were recruited in their conservative stage of treatment. After profiling their physical status, all participants reported about pain level (according to VAS), pain perception using the Pain Catastrophizing Scale (PCS), and disability level (according to Oswestry Low Back Pain Disability Questionnaire)...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27860424/aerosol-transport-throughout-inspiration-and-expiration-in-the-pulmonary-airways
#10
Jessica M Oakes, Shawn C Shadden, Céline Grandmont, Irene E Vignon-Clementel
Little is known about transport throughout the respiration cycle in the conducting airways. It is challenging to appropriately describe the time-dependent number of particles entering back into the model during exhalation. Modeling the entire lung is not feasible; therefore multi-domain methods must be employed. Here, we present a new framework that is designed to simulate particles throughout the respiration cycle, incorporating realistic airway geometry and respiration. This framework is applied for a healthy rat lung exposed to  ∼ 1μm diameter particles to facilitate parameterization and validation...
November 2, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27858725/2-year-clinical-results-of-patients-with-sacroiliac-joint-syndrome-treated-by-arthrodesis-using-a-triangular-implant-system
#11
Rahel Bornemann, Philip P Roessler, Andreas Strauss, Kirsten Sander, Yorck Rommelspacher, Dieter C Wirtz, Robert Pflugmacher, Sönke P Frey
BACKGROUND: Sacroiliac joint (SIJ) syndrome can cause various symptoms and may also be one reason for persistent low back pain, especially in patients with prior spinal fusions. If conservative treatments fail to improve symptoms, arthrodesis surgery can be considered. Minimally invasive approaches have emerged recently providing a good alternative to conventional methods. A novel triangular implant system (iFuse) can achieve an arthrodesis of the SIJ without the use of additional screws or bone material...
November 4, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27858699/adolescent-lumbar-disc-herniation-impact-diagnosis-and-treatment
#12
Mustafa Karademir, Olcay Eser, Ergün Karavelioglu
BACKGROUND: Symptomatic lumbar intervertebral disc herniation (LDH) is rare in children and adolescents. To date, the treatments available for child and adolescent LDH, and the effect of each treatment, have not been fully reviewed. OBJECTIVE: The purpose of this retrospective study is to report the etiology, familial history, presenting symptoms, level of herniation, duration of symptoms, radiological findings, as well as treatment methods and outcome. METHODS: We retrospectively reviewed medical records of all patients with inclusion criteria of being younger than 20 years...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27853391/failed-back-surgery-syndrome-current-perspectives
#13
REVIEW
Zafeer Baber, Michael A Erdek
The treatment of failed back surgery syndrome (FBSS) can be equally challenging to surgeons, pain specialists, and primary care providers alike. The onset of FBSS occurs when surgery fails to treat the patient's lumbar spinal pain. Minimizing the likelihood of FBSS is dependent on determining a clear etiology of the patient's pain, recognizing those who are at high risk, and exhausting conservative measures before deciding to go into a revision surgery. The workup of FBSS includes a thorough history and physical examination, diagnostic imaging, and procedures...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27843738/haglund-s-syndrome-a-commonly-seen-mysterious-condition
#14
REVIEW
Raju Vaishya, Amit Kumar Agarwal, Ahmad Tariq Azizi, Vipul Vijay
Haglund's deformity was first described by Patrick Haglund in 1927. It is also known as retrocalcaneal exostosis, Mulholland deformity, and 'pump bump.' It is a very common clinical condition, but still poorly understood. Haglund's deformity is an abnormality of the bone and soft tissues in the foot. An enlargement of the bony section of the heel (where the Achilles tendon is inserted) triggers this condition. The soft tissue near the back of the heel can become irritated when the large, bony lump rubs against rigid shoes...
October 7, 2016: Curēus
https://www.readbyqxmd.com/read/27843689/transition-of-a-herniated-lumbar-disc-to-lumbar-discal-cyst-a-case-report
#15
Rohit Bansil, Yoshitaka Hirano, Hideo Sakuma, Kazuo Watanabe
BACKGROUND: Another rare cause of lower back pain with radiculopathy is the discal cyst. It is believed to arise from degeneration of a herniated disc, although many other theories of its origin have been proposed. Here, we report a patient with lower back pain/radiculopathy attributed originally to a herniated lumbar disc, which transformed within 6 months into a discal cyst. CASE DESCRIPTION: A 42-year-old male had a magnetic resonance (MR) documented herniated lumbar disc at the L4-5 level...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27843682/large-spontaneous-spinal-subdural-epidural-hematoma-after-epidural-anesthesia-for-caesarean-section-conservative-management-with-excellent-outcome
#16
Ioannis D Siasios, Kunal Vakharia, Kevin J Gibbons, Vassilios G Dimopoulos
BACKGROUND: Iatrogenic or spontaneous spinal hematomas are rarely seen and present with multiple symptoms that can be difficult to localize. Most spontaneous spinal hematomas are multifactorial, and the pathophysiology is varied. Here, we present a case of a scattered, multicomponent, combined subdural and epidural spinal hematoma that was managed conservatively. CASE DESCRIPTION: A 38-year-old woman came to the emergency department (ED) complaining of severe neck and back pain...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27831489/increased-sagittal-vertical-axis-is-associated-with-less-effective-control-of-acute-pain-following-vertebroplasty
#17
Y-C Kim, D H Bok, H-G Chang, S W Kim, M S Park, J K Oh, J Kim, T-H Kim
OBJECTIVES: Although vertebroplasty is very effective for relieving acute pain from an osteoporotic vertebral compression fracture, not all patients who undergo vertebroplasty receive the same degree of benefit from the procedure. In order to identify the ideal candidate for vertebroplasty, pre-operative prognostic demographic or clinico-radiological factors need to be identified. The objective of this study was to identify the pre-operative prognostic factors related to the effect of vertebroplasty on acute pain control using a cohort of surgically and non-surgically managed patients...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27826089/ulf-fernstrom-1915-1985-and-his-contributions-to-the-development-of-artificial-disc-replacements-a-historical-vignette
#18
REVIEW
Christian Fisahn, Brittni Burgess, Joe Iwanaga, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: Artificial disc replacements, which serve the function of separating vertebrae to allow for proper spinal alignment, can help treat debilitating low back pain in patients who have failed other conservative methods of treatment. Ulf Fernstrom was the pioneer of artificial disc replacement, and his contribution in the way of Fernstrom "Balls" dramatically altered spinal surgery and technique by demonstrating the proper technique and implant that should be utilized for areas requiring motion in many planes...
November 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27814692/a-set-of-genes-conserved-in-sequence-and-expression-traces-back-the-establishment-of-multicellularity-in-social-amoebae
#19
Christina Schilde, Hajara M Lawal, Angelika A Noegel, Ludwig Eichinger, Pauline Schaap, Gernot Glöckner
BACKGROUND: The developmental cycle of Dictyostelid amoebae represents an early form of multicellularity with cell type differentiation. Mutant studies in the model Dictyostelium discoideum revealed that its developmental program integrates the actions of genes involved in signal transduction, adhesion, motility, autophagy and cell wall and matrix biosynthesis. However, due to functional redundancy and fail safe options not required in the laboratory, this single organism approach cannot capture all essential genes...
November 4, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27812802/biotechnological-potential-of-actinobacteria-from-canadian-and-azorean-volcanic-caves
#20
Cristina Riquelme, Maria de Lurdes Enes Dapkevicius, Ana Z Miller, Zachary Charlop-Powers, Sean Brady, Cohord Mason, Naowarat Cheeptham
Caves are regarded as extreme habitats with appropriate conditions for the development of Actinobacteria. In comparison with other habitats, caves have not yet been the target of intensive screening for bioactive secondary metabolites produced by actinomycetes. As a primary screening strategy, we conducted a metagenomic analysis of the diversity and richness of a key gene required for non-ribosomal peptide (NRP) biosynthesis, focusing on cave-derived sediments from two Canadian caves (a lava tube and a limestone cave) to help us predict whether different types of caves may harbor drug-producing actinobacteria...
November 3, 2016: Applied Microbiology and Biotechnology
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