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Bk channel pgd

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https://www.readbyqxmd.com/read/25653620/single-channel-kinetics-of-bk-slo1-channels
#1
REVIEW
Yanyan Geng, Karl L Magleby
Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts with single-channel current records and progresses to presentation and analysis of single-channel data and the development of gating mechanisms in terms of discrete state Markov (DSM) models. The DSM models are formulated in terms of the tetrameric modular structure of BK channels, consisting of a central transmembrane pore-gate domain (PGD) attached to four surrounding transmembrane voltage sensing domains (VSD) and a large intracellular cytosolic domain (CTD), also referred to as the gating ring...
2014: Frontiers in Physiology
https://www.readbyqxmd.com/read/23825428/the-interface-between-membrane-spanning-and-cytosolic-domains-in-ca%C3%A2-dependent-k-channels-is-involved-in-%C3%AE-subunit-modulation-of-gating
#2
Xiaohui Sun, Jingyi Shi, Kelli Delaloye, Xiao Yang, Huanghe Yang, Guohui Zhang, Jianmin Cui
Large-conductance, voltage-, and Ca²⁺-dependent K⁺ (BK) channels are broadly expressed in various tissues to modulate neuronal activity, smooth muscle contraction, and secretion. BK channel activation depends on the interactions among the voltage sensing domain (VSD), the cytosolic domain (CTD), and the pore gate domain (PGD) of the Slo1 α-subunit, and is further regulated by accessory β subunits (β1-β4). How β subunits fine-tune BK channel activation is critical to understand the tissue-specific functions of BK channels...
July 3, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/22529812/regulation-of-voltage-activated-k-channel-gating-by-transmembrane-%C3%AE-subunits
#3
Xiaohui Sun, Mark A Zaydman, Jianmin Cui
Voltage-activated K(+) (K(V)) channels are important for shaping action potentials and maintaining resting membrane potential in excitable cells. K(V) channels contain a central pore-gate domain (PGD) surrounded by four voltage-sensing domains (VSDs). The VSDs will change conformation in response to alterations of the membrane potential thereby inducing the opening of the PGD. Many K(V) channels are heteromeric protein complexes containing auxiliary β subunits. These β subunits modulate channel expression and activity to increase functional diversity and render tissue specific phenotypes...
2012: Frontiers in Pharmacology
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