keyword
MENU ▼
Read by QxMD icon Read
search

Kat7

keyword
https://www.readbyqxmd.com/read/27733580/essential-role-for-the-histone-acetyltransferase-kat7-in-t-cell-development-fitness-and-survival
#1
Dane M Newman, Anne K Voss, Tim Thomas, Rhys S Allan
Histone acetylation has an important role in gene regulation, DNA replication, and repair. Because these processes are central to the development of the immune system, we investigated the role of a previously unstudied histone acetyltransferase named KAT7 (also known as Myst2 or HBO1) in the regulation of thymopoiesis and observed a critical role in the regulation of conventional and innate-like T cell development. We found that KAT7-deficient thymocytes displayed normal, positive selection and development into mature single-positive αβ thymocytes; however, we observed few peripheral CD4(+) or CD8(+) T cells...
October 12, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27709438/3d-structure-prediction-of-histone-acetyltransferase-proteins-of-the-myst-family-and-their-interactome-in-arabidopsis-thaliana
#2
A V Raevsky, M Sharifi, D A Samofalova, P A Karpov, Y B Blume
Histone lysine acetylation is a reversible post-translational modification that does not involve changes in DNA sequences. Enzymes play an important role in developmental processes and their deregulation has been linked to the progression of diverse disorders. The HAT enzyme family fulfills an important role in various developmental processes mediated by the state of chromatin, and have been attributed to its deregulation. To understand acetylation mechanisms and their role in cell signaling, transcriptional regulation, and apoptosis, it is crucial to identify and analyze acetylation sites...
November 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27500495/brpf1-is-essential-for-development-of-fetal-hematopoietic-stem-cells
#3
Linya You, Lin Li, Jinfeng Zou, Kezhi Yan, Jad Belle, Anastasia Nijnik, Edwin Wang, Xiang-Jiao Yang
Hematopoietic stem cells (HSCs) serve as a life-long reservoir for all blood cell types and are clinically useful for a variety of HSC transplantation-based therapies. Understanding the role of chromatin organization and regulation in HSC homeostasis may provide important insights into HSC development. Bromodomain- and PHD finger-containing protein 1 (BRPF1) is a multivalent chromatin regulator that possesses 4 nucleosome-binding domains and activates 3 lysine acetyltransferases (KAT6A, KAT6B, and KAT7), suggesting that this protein has the potential to stimulate crosstalk between different chromatin modifications...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27270040/kat7-hbo1-myst2-regulates-cenp-a-chromatin-assembly-by-antagonizing-suv39h1-mediated-centromere-inactivation
#4
Jun-Ichirou Ohzeki, Nobuaki Shono, Koichiro Otake, Nuno M C Martins, Kazuto Kugou, Hiroshi Kimura, Takahiro Nagase, Vladimir Larionov, William C Earnshaw, Hiroshi Masumoto
Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads into adjacent chromatin and represses gene expression, and it can antagonize centromere function or CENP-A assembly. Here, we demonstrate an interaction between CENP-A assembly factor M18BP1 and acetyltransferase KAT7/HBO1/MYST2...
June 6, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27270035/the-kat-s-out-of-the-bag-histone-acetylation-promotes-centromere-assembly
#5
Jason Palladino, Barbara G Mellone
Heterochromatin is incompatible with centromeric chromatin assembly and propagation. In this issue of Developmental Cell, Ohzeki et al. (2016) reveal that a critical role of the Mis18 complex is to transiently recruit the lysine acetyltransferase KAT7 to centromeres to facilitate the removal of H3K9me3 and the deposition of CENP-A.
June 6, 2016: Developmental Cell
https://www.readbyqxmd.com/read/26767057/histone-acetylation-and-histone-acetyltransferases-show-significant-alterations-in-human-abdominal-aortic-aneurysm
#6
Yanshuo Han, Fadwa Tanios, Christian Reeps, Jian Zhang, Kristina Schwamborn, Hans-Henning Eckstein, Alma Zernecke, Jaroslav Pelisek
BACKGROUND: Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of corresponding lysine [K] histone acetyltransferases (KATs) in AAA. RESULTS: A comparative study of AAA tissue samples (n = 37, open surgical intervention) and healthy aortae (n = 12, trauma surgery) was performed using quantitative PCR, immunohistochemistry (IHC), and Western blot...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/26045981/status-of-epigenetic-chromatin-modification-enzymes-and-esophageal-squamous-cell-carcinoma-risk-in-northeast-indian-population
#7
Virendra Singh, Laishram C Singh, Avninder P Singh, Jagannath Sharma, Bibhuti B Borthakur, Arundhati Debnath, Avdhesh K Rai, Rup K Phukan, Jagadish Mahanta, Amal C Kataki, Sujala Kapur, Sunita Saxena
Esophageal cancer incidence is reported in high frequency in northeast India. The etiology is different from other population at India due to wide variations in dietary habits or nutritional factors, tobacco/betel quid chewing and alcohol habits. Since DNA methylation, histone modification and miRNA-mediated epigenetic processes alter the gene expression, the involvement of these processes might be useful to find out epigenetic markers of esophageal cancer risk in northeast Indian population. The present investigation was aimed to carryout differential expression profiling of chromatin modification enzymes in tumor and normal tissue collected from esophageal squamous cell carcinoma (ESCC) patients...
2015: American Journal of Cancer Research
https://www.readbyqxmd.com/read/25773539/the-chromatin-regulator-brpf1-regulates-embryo-development-and-cell-proliferation
#8
Linya You, Kezhi Yan, Jinfeng Zou, Hong Zhao, Nicholas R Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang
With hundreds of chromatin regulators identified in mammals, an emerging issue is how they modulate biological and pathological processes. BRPF1 (bromodomain- and PHD finger-containing protein 1) is a unique chromatin regulator possessing two PHD fingers, one bromodomain and a PWWP domain for recognizing multiple histone modifications. In addition, it binds to the acetyltransferases MOZ, MORF, and HBO1 (also known as KAT6A, KAT6B, and KAT7, respectively) to promote complex formation, restrict substrate specificity, and enhance enzymatic activity...
May 1, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25757017/the-lysine-acetyltransferase-activator-brpf1-governs-dentate-gyrus-development-through-neural-stem-cells-and-progenitors
#9
Linya You, Kezhi Yan, Jinfeng Zou, Jinfeng Zhou, Hong Zhao, Nicholas R Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang
Lysine acetylation has recently emerged as an important post-translational modification in diverse organisms, but relatively little is known about its roles in mammalian development and stem cells. Bromodomain- and PHD finger-containing protein 1 (BRPF1) is a multidomain histone binder and a master activator of three lysine acetyltransferases, MOZ, MORF and HBO1, which are also known as KAT6A, KAT6B and KAT7, respectively. While the MOZ and MORF genes are rearranged in leukemia, the MORF gene is also mutated in prostate and other cancers and in four genetic disorders with intellectual disability...
March 2015: PLoS Genetics
https://www.readbyqxmd.com/read/25568313/deficiency-of-the-chromatin-regulator-brpf1-causes-abnormal-brain-development
#10
Linya You, Jinfeng Zou, Hong Zhao, Nicholas R Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang
Epigenetic mechanisms are important in different neurological disorders, and one such mechanism is histone acetylation. The multivalent chromatin regulator BRPF1 (bromodomain- and plant homeodomain-linked (PHD) zinc finger-containing protein 1) recognizes different epigenetic marks and activates three histone acetyltransferases, so it is both a reader and a co-writer of the epigenetic language. The three histone acetyltransferases are MOZ, MORF, and HBO1, which are also known as lysine acetyltransferase 6A (KAT6A), KAT6B, and KAT7, respectively...
March 13, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/23625935/small-molecule-inhibitors-of-acetyltransferase-p300-identified-by-high-throughput-screening-are-potent-anticancer-agents
#11
Heng Yang, Christie E Pinello, Jian Luo, Dawei Li, Yunfei Wang, Lisa Y Zhao, Stephan C Jahn, Sanjay Adrian Saldanha, Peter Chase, Jamie Planck, Kyla R Geary, Haiching Ma, Brian K Law, William R Roush, Peter Hodder, Daiqing Liao
Acetyltransferase p300 (KAT3B) plays key roles in signaling cascades that support cancer cell survival and sustained proliferation. Thus, p300 represents a potential anticancer therapeutic target. To discover novel anticancer agents that target p300, we conducted a high-throughput screening campaign. A library of 622,079 compounds was assayed for cytotoxicity to the triple-negative breast cancer (TNBC) cell line MDA-MB-231 but not to the human mammary epithelial cells. The resulting compounds were tested in a biochemical assay for inhibiting the enzymatic activity of p300...
May 2013: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/23524580/identifying-targets-for-the-restoration-and-reactivation-of-brm
#12
B Kahali, S J B Gramling, S B Marquez, K Thompson, L Lu, D Reisman
Brahma (BRM) is a novel anticancer gene, which is frequently inactivated in a variety of tumor types. Unlike many anticancer genes, BRM is not mutated, but rather epigenetically silenced. In addition, histone deacetylase complex (HDAC) inhibitors are known to reverse BRM silencing, but they also inactivate it via acetylation of its C-terminus. High-throughput screening has uncovered many compounds that are effective at pharmacologically restoring BRM and thereby inhibit cancer cell growth. As we do not know which specific proteins, if any, regulate BRM, we sought to identify the proteins, which underlie the epigenetic suppression of BRM...
January 30, 2014: Oncogene
https://www.readbyqxmd.com/read/21149574/hbo1-is-required-for-h3k14-acetylation-and-normal-transcriptional-activity-during-embryonic-development
#13
Andrew J Kueh, Mathew P Dixon, Anne K Voss, Tim Thomas
We report here that the MYST histone acetyltransferase HBO1 (histone acetyltransferase bound to ORC; MYST2/KAT7) is essential for postgastrulation mammalian development. Lack of HBO1 led to a more than 90% reduction of histone 3 lysine 14 (H3K14) acetylation, whereas no reduction of acetylation was detected at other histone residues. The decrease in H3K14 acetylation was accompanied by a decrease in expression of the majority of genes studied. However, some genes, in particular genes regulating embryonic patterning, were more severely affected than "housekeeping" genes...
February 2011: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/18713817/deoxyribonucleic-acid-profiling-analysis-of-40-human-thyroid-cancer-cell-lines-reveals-cross-contamination-resulting-in-cell-line-redundancy-and-misidentification
#14
Rebecca E Schweppe, Joshua P Klopper, Christopher Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A Knauf, James A Fagin, Laura A Marlow, John A Copland, Robert C Smallridge, Bryan R Haugen
CONTEXT: Cell lines derived from human cancers provide critical tools to study disease mechanisms and develop novel therapies. Recent reports indicate that up to 36% of cell lines are cross- contaminated. OBJECTIVE: We evaluated 40 reported thyroid cancer-derived cell lines using short tandem repeat and single nucleotide polymorphism array analysis. RESULTS: Only 23 of 40 cell lines tested have unique genetic profiles. The following groups of cell lines are likely derivatives of the same cell line: BHP5-16, BHP17-10, BHP14-9, and NPA87; BHP2-7, BHP10-3, BHP7-13, and TPC1; KAT5, KAT10, KAT4, KAT7, KAT50, KAK1, ARO81-1, and MRO87-1; and K1 and K2...
November 2008: Journal of Clinical Endocrinology and Metabolism
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"