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Beta-lactam

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https://www.readbyqxmd.com/read/28548661/co-evolution-with-staphylococcus-aureus-leads-to-lipopolysaccharide-alterations-in-pseudomonas-aeruginosa
#1
Mikael Tognon, Thilo Köhler, Bartosz G Gdaniec, Youai Hao, Joseph S Lam, Marie Beaume, Alexandre Luscher, Angus Buckling, Christian van Delden
Detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. In cystic fibrosis (CF) airways, Staphylococcus aureus prevails in childhood, whereas Pseudomonas aeruginosa progressively predominates thereafter. While a range of interactions has been identified, it is unclear if these represent specific adaptations or correlated responses to other aspects of the environment. Here, we investigate how P. aeruginosa adapts to S. aureus by evolving P. aeruginosa in the presence and absence of S...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28543395/contact-urticaria-syndrome-with-ige-antibody-against-a-cefotiam-unique-structure-evoked-by-nonapparent-exposure-to-cefotiam
#2
S Takahagi, A Tanaka, K Iwamoto, K Ishii, M Hide
A 26-year-old woman presented with recurrent attacks of widespread urticaria and systemic symptoms. The patient was a nurse, and the attacks occurred only in her workplace, without an apparent trigger. A patch test to cefotiam (CTM) induced an immediate skin reaction. ELISA detected the patient's serum IgE antibody binding to CTM conjugated with human serum albumin (CTM-HSA), and her basophils released histamine in response to CTM-HSA in a histamine release assay (HRA). Both reactions in ELISA and HRA were inhibited by pretreatment of the patient's serum or basophils with cefotiam...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28522729/draft-genome-sequences-of-two-streptococcus-pneumoniae-serotype-19a-sequence-type-226-clinical-isolates-from-hungary-hu17-with-high-level-beta-lactam-resistance-and-hu15-of-a-penicillin-sensitive-phenotype
#3
Martin Rieger, Dalia Denapaite, Reinhold Brückner, Patrick Maurer, Regine Hakenbeck
The draft genome sequences of two multiple-antibiotic-resistant Streptococcus pneumoniae isolates from Hungary, Hu15 and Hu17, are reported here. Strain Hu15 is penicillin susceptible, whereas Hu17 is a high-level-penicillin-resistant strain. Both isolates belong to the serotype 19A sequence type 226, a single-locus variant (in the ddl locus) of the Hungary(19A)-6 clone.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28522725/draft-genome-sequences-of-five-enterococcus-species-isolated-from-the-gut-of-patients-with-suspected-clostridium-difficile-infection
#4
Eduardo Castro-Nallar, Sandro L Valenzuela, Sebastián Baquedano, Carolina Sánchez, Fabiola Fernández, Annette N Trombert
We present draft genome sequences of five Enterococcus species from patients suspected of Clostridium difficile infection. Genome completeness was confirmed by presence of bacterial orthologs (97%). Gene searches using Hidden-Markov models revealed that the isolates harbor between seven and 11 genes involved in antibiotic resistance to tetracyclines, beta-lactams, and vancomycin.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28520761/antibiotic-use-in-south-korea-from-2007-to-2014-a-health-insurance-database-generated-time-series-analysis
#5
Juhee Park, Euna Han, Soo Ok Lee, Dong-Sook Kim
BACKGROUND: Inappropriate antibiotic use significantly contributes to antibiotic-resistance, resulting in reduced antibiotic efficacy and increasing physical burden and cost of disease. The goal of this study was to explore antibiotic usage patterns in South Korea using 2007-2014 health insurance claims data. METHODS: We used the Health Insurance Review & Assessment Service data, which represents nearly the entire population of South Korea, to discern patterns in antibiotic prescribing practices...
2017: PloS One
https://www.readbyqxmd.com/read/28515059/antibiotic-stability-over-six-weeks-in-aqueous-solution-at-body-temperature-with-and-without-heat-treatment-that-mimics-the-curing-of-bone-cement
#6
E Samara, T F Moriarty, L A Decosterd, R G Richards, E Gautier, P Wahl
OBJECTIVES: Thermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections. Despite the fact that long-term therapy is a stated goal of novel local delivery carriers, data describing thermal stability over a long period are scarce, and studies that avoid interference from specific carrier materials are absent from the orthopaedic literature. METHODS: In this study, a total of 38 frequently used antibiotic agents were maintained at 37°C in saline solution, and degradation and antibacterial activity assessed over six weeks...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28512093/population-genomic-analysis-of-1-777-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolates-houston-texas-unexpected-abundance-of-clonal-group-307
#7
S Wesley Long, Randall J Olsen, Todd N Eagar, Stephen B Beres, Picheng Zhao, James J Davis, Thomas Brettin, Fangfang Xia, James M Musser
Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and mortality rates. The emergence and spread of strains resistant to multiple antimicrobial agents and documented large nosocomial outbreaks are especially concerning. To develop new therapeutic strategies for K. pneumoniae, it is imperative to understand the population genomic structure of strains causing human infections. To address this knowledge gap, we sequenced the genomes of 1,777 extended-spectrum beta-lactamase-producing K...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28511040/removal-of-selected-ppcps-edcs-and-antibiotic-resistance-genes-in-landfill-leachate-by-a-full-scale-constructed-wetlands-system
#8
Xinzhu Yi, Ngoc Han Tran, Tingru Yin, Yiliang He, Karina Yew-Hoong Gin
Landfill leachate could be a significant source of emerging contaminants (ECs) and antibiotic resistance genes (ARGs) into the environment. This study provides the first information on the occurrence of selected ECs and ARGs in raw leachate from 16-year old closed landfill site in Singapore. Among the investigated ECs, acetaminophen (ACT), bisphenol A (BPA), clofibric acid (CA), caffeine (CF), crotamiton (CTMT), diclofenac (DCF), N,N-diethyl-m-toluamide (DEET), gemfibrozil (GFZ), lincomycin (LIN), salicylic acid (SA), and sulfamethazine (SMZ) were the most frequently detected compounds in raw landfill leachate...
May 8, 2017: Water Research
https://www.readbyqxmd.com/read/28508147/identification-of-beta-lactamases-and-beta-lactam-related-proteins-in-human-pathogenic-bacteria-using-a-computational-search-approach
#9
Aniel Jessica Leticia Brambila-Tapia, Ernesto Perez-Rueda, Humberto Barrios, Nory Omayra Dávalos-Rodríguez, Ingrid Patricia Dávalos-Rodríguez, Ernesto Germán Cardona-Muñoz, Mario Salazar-Páramo
A systematic analysis of beta-lactamases based on comparative proteomics has not been performed thus far. In this report, we searched for the presence of beta-lactam-related proteins in 591 bacterial proteomes belonging to 52 species that are pathogenic to humans. The amino acid sequences for 19 different types of beta-lactamases (ACT, CARB, CifA, CMY, CTX, FOX, GES, GOB, IMP, IND, KPC, LEN, OKP, OXA, OXY, SHV, TEM, NDM, and VIM) were obtained from the ARG-ANNOT database and were used to construct 19 HMM profiles, which were used to identify potential beta-lactamases in the completely sequenced bacterial proteomes...
May 16, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28506721/first-report-of-ndm-1-producing-clinical-isolate-of-leclercia-adecarboxylata-in-spain
#10
Cristina Riazzo, Lorena López-Cerero, María Dolores Rojo-Martín, Yannick Hoyos-Mallecot, Felipe Fernández-Cuenca, Jose Luis Martín-Ruíz, Álvaro Pascual-Hernández, Thierry Naas, Jose María Navarro-Marí
We describe the case of NDM-1-producing Leclercia adecarboxylata recovered from the clinical sample of a patient hospitalized for a trauma-related injury to his foot. The isolate was resistant to all beta-lactams, quinolones, trimetroprim-sulfametoxazol, gentamicin and tobramicyn. The blaNDM-1 gene was located in a conjugative plasmid that also contained the blaSHV-12 gene and was preceded by a disrupted insertion sequence of ISAba125. The plasmid belongs to the incompatibility group X3, which is known to be an important vector for NDM-1 dissemination in China...
May 3, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28504816/virulence-factors-and-antimicrobial-resistance-in-environmental-strains-of-vibrio-alginolyticus
#11
Marcos F Hernández-Robles, Ana K Álvarez-Contreras, Patricia Juárez-García, Iván Natividad-Bonifacio, Everardo Curiel-Quesada, Carlos Vázquez-Salinas, Elsa I Quiñones-Ramírez
Vibrio alginolyticus has acquired increasing importance because this microorganism may be pathogenic to aquatic animals and humans. It has been reported that some V. alginolyticus strains carry virulence genes derived from pathogenic V. cholerae and V. parahaemolyticus strains. In this work V. alginolyticus was isolated from oyster samples acquired from a food-market in Mexico City. Thirty isolates were identified as V. alginolitycus. Strains showed β-haemolysis and proteolytic activity and produced a capsule...
December 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28504314/next-step-in-antibiotic-stewardship-pharmacist-provided-penicillin-allergy-testing
#12
Z Gugkaeva, J S Crago, M Yasnogorodsky
WHAT IS KNOWN: Penicillin allergy limits therapeutic options for patients but often disappears over time, leaving patients erroneously labelled allergic and leading to the utilization of broad-spectrum and more expensive antibiotics. Penicillin allergy can be effectively assessed via skin testing. OBJECTIVE: To improve patient access to penicillin allergy testing by implementing a pharmacist-provided service in a hospital setting. COMMENT: Beta-lactams remain a mainstream therapy for many infections due to their effectiveness, low side effects and affordability...
May 14, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28503496/prevalence-of-acquired-carbapenemase-genes-in-klebsiella-pneumoniae-by-multiplex-pcr-in-isfahan
#13
Farzin Khorvash, Mohammed Reza Yazdani, Ali Asghar Soudi, Shiva Shabani, Nirvana Tavahen
BACKGROUND: Multi-drug resistant Klebsiella pneumoniae has been considered as a serious global threat. This study was done to investigate carbapenemase producing genomes among K. pneumoniae isolates in Isfahan, Central Iran. MATERIALS AND METHODS: In a cross-sectional study from 2011 to 2012, 29 carbapenem resistant (according to disc diffusion method) carbapenemase producing (according to modified Hodge test) K. pneumoniae strains were collected from Intensive Care Unit (ICUs) of Al-Zahra referral Hospital...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28501668/response-adjusted-for-days-of-antibiotic-risk-radar-evaluation-of-a-novel-method-to-compare-strategies-to-optimise-antibiotic-use
#14
Valentijn A Schweitzer, Maarten van Smeden, Douwe F Postma, Jan Jelrik Oosterheert, Marc J M Bonten, Cornelis H van Werkhoven
OBJECTIVES: The Response Adjusted for Days of Antibiotic Risk (RADAR)-statistic was proposed to improve efficiency of trials comparing antibiotic stewardship strategies to optimize antibiotic use. We studied the behaviour of RADAR in a non-inferiority trial in which a beta-lactam monotherapy strategy (BL, n=656) was non-inferior to fluoroquinolone monotherapy (FQL, n=888) for moderately-severe community-acquired pneumonia (CAP) patients. METHODS: Patients were ranked according to clinical outcome, using five or eight categories, and antibiotic use...
May 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28500123/enterococcus-casseliflavus-septicaemia-associated-with-hepatobiliary-infection-in-a-75-year-old-man
#15
Rajanshu Verma, Allison L Baroco
Enterococcus casseliflavus is a rare non-faecium, non-faecalis, vancomycin-resistant enterococcus (VRE) that is responsible for up to 2% of all enterococcal infections. Septicaemia with this bacterium is usually seen in older patients with multiple comorbidities who have had several previous hospitalisations. Septicaemia with E. casseliflavus portends a poorer prognosis, and treatment usually involves administration of antienterococcal beta-lactams or anti-VRE medications such as linezolid or daptomycin. We present such a case of a 75-year-old man who developed E...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28499129/occurrence-of-antimicrobial-resistance-bacteria-in-the-yodo-river-basin-japan-and-determination-of-beta-lactamases-producing-bacteria
#16
Naoyuki Yamashita, Yohei Katakawa, Hiroaki Tanaka
Antimicrobial resistant bacteria are widespread in aquatic environments. The aim of the present study was to obtain information on the occurrence of bacteria with antimicrobial resistance and their multiple antimicrobial resistance (MAR) patterns in a river basin in Japan. In addition, the occurrence of fecal bacteria producing extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamase (MBL) in the aquatic environment was determined. Among the Escherichia coli isolates recovered from river samples upstream, 55% isolates were resistant to at least one antimicrobial and 18% were MAR...
May 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28494608/parenteral-nutrition-in-childhood-and-consequences-for-dentition-and-gingivae
#17
D Olczak-Kowalczyk, M Danko, E Banaś, D Gozdowski, K Popińska, E Krasuska-Sławińska, J Książyk
AIM: Assessment of dentition in children under parenteral nutrition, risk factors for caries, and dental developmental abnormalities. MATERIALS AND METHODS: The study involved 63 patients (aged 2.25-16.6 years), i.e. 32 subjects receiving parenteral nutrition for a mean period of 5.6±2.94 years, and 31 healthy control subjects. Oral hygiene (OHI-S, PL-I), gingival (GI), and dentition status (caries, DMFT/dmft, enamel defects, shape alterations), frequency of oral meals and frequency of cariogenic snacks consumption were evaluated...
March 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28490487/bifidobacterium-bacteremia-clinical-characteristics-and-a-genomic-approach-to-assess-pathogenicity
#18
Eirin Esaiassen, Erik Hjerde, Jorunn Pauline Cavanagh, Gunnar Skov Simonsen, Claus Klingenberg
Bifidobacteria are commensals that colonize the orogastrointestinal tract, and rarely cause invasive human infections. However, an increasing number of bifidobacterial blood culture isolates has lately been observed in Norway. In order to investigate the pathogenicity of Bifidobacterium species responsible for bacteremia, we studied Bifidobacterium isolates from 15 patients with a positive blood culture obtained during 2013 to 2015. We collected clinical data and analyzed phenotypic and genotypic antibiotic susceptibility...
May 10, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28483315/addressing-inpatient-beta-lactam-allergies-a-multihospital-implementation
#19
REVIEW
Kimberly G Blumenthal, Erica S Shenoy, Anna R Wolfson, David N Berkowitz, Victoria A Carballo, Diana S Balekian, Kathleen A Marquis, Ramy Elshaboury, Ronak G Gandhi, Praveen Meka, David W Kubiak, Jennifer Catella, Barbara B Lambl, Joyce T Hsu, Monique M Freeley, Alana Gruszecki, Paige G Wickner
Addressing inaccurate penicillin allergies is encouraged as part of antibiotic stewardship in the inpatient setting. However, implementing interventions targeted at the 10% to 15% of inpatients reporting a previous penicillin allergy can pose substantial logistic challenges. We implemented a computerized guideline for patients with reported beta-lactam allergy at 5 hospitals within a single health care system in the Boston area. In this article, we describe our implementation roadmap, including both successes achieved and challenges faced...
May 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28480152/bifidobacterium-an-emerging-clinically-significant-metronidazole-resistant-anaerobe-of-mixed-pyogenic-infections
#20
Hena Butta, Raman Sardana, Raju Vaishya, Kailash N Singh, Leena Mendiratta
Bifidobacterium sp. are anaerobic, Gram-positive, short, irregular rods with rudimentary branching. These organisms are reported to be associated with health benefits and their significance as a pathogen is not much reported. We are reporting two cases of mixed pyogenic infections due to Bifidobacterium sp. In the first patient, the infection mimicked tubercular bone infection. The second patient was a case of hydronephrosis with double J (DJ) stent blockage. In both cases, Bifidobacterium sp. was isolated in combination with Escherichia coli from the evacuated pus samples...
April 4, 2017: Curēus
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