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Acute Respiratory Distress Syndrome

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https://www.readbyqxmd.com/read/29926908/intensive-care-doctors-preferences-for-arterial-oxygen-tension-levels-in-mechanically-ventilated-patients
#1
O L Schjørring, A P Toft-Petersen, K H Kusk, P Mouncey, E E Sørensen, P Berezowicz, M H Bestle, H-H Bülow, H Bundgaard, S Christensen, S A Iversen, I Kirkeby-Garstad, K B Krarup, M Kruse, J H Laake, L Liboriussen, R L Laebel, M Okkonen, L M Poulsen, L Russell, F Sjövall, K Sunde, E Søreide, T Waldau, A R Walli, A Perner, J Wetterslev, B S Rasmussen
BACKGROUND: Oxygen is liberally administered in intensive care units (ICUs). Nevertheless, ICU doctors' preferences for supplementing oxygen are inadequately described. The aim was to identify ICU doctors' preferences for arterial oxygenation levels in mechanically ventilated adult ICU patients. METHODS: In April to August 2016, an online multiple-choice 17-part-questionnaire was distributed to 1080 ICU doctors in seven Northern European countries. Repeated reminder e-mails were sent...
June 21, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29925137/-advances-of-hepatocyte-growth-factor-in-treatment-of-acute-respiratory-distress-syndrome
#2
S S Meng, Z H Lu, F M Guo
No abstract text is available yet for this article.
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924305/telocytes-promote-vegf-expression-and-alleviate-ventilator-induced-lung-injury-in-mice
#3
Ruihua Ma, Pinwen Wu, Qiqing Shi, Dongli Song, Hao Fang
Mechanical ventilation (MV) is an important procedure for the treatment of patients with acute lung injury or acute respiratory distress syndrome in a clinical setting; however, MV can lead to severe complications, including ventilator-induced lung injury (VILI). Telocytes (TCs) can promote tissue repair following injury in the heart, kidneys, and other organs. The aim of this study was to investigate the role of TCs in VILI in mice and the associated mechanisms. By using in vivo studies in mice and in vitro studies in cells, we demonstrated that an airway injection of TCs can reduce the pulmonary inflammatory response and improve the lung function in mice with VILI and promote the proliferation of pulmonary vascular endothelial cells...
June 19, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29923937/pulmonary-functions-in-children-ventilated-for-acute-hypoxemic-respiratory-failure
#4
Stanzen Chakdour, Pankaj C Vaidya, Suresh Kumar Angurana, Jayashree Muralidharan, Meenu Singh, Sunit C Singhi
OBJECTIVE: To assess pulmonary functions of children who received mechanical ventilation for acute hypoxemic respiratory failure. DESIGN: Longitudinal study. SETTING: PICU and Pediatric Pulmonology Clinic of a tertiary care teaching hospital in North India. PATIENTS: All children, 5-12 years old, ventilated for acute hypoxemic respiratory failure in PICU from July 2012 to June 2013 and survived. INTERVENTIONS: The baseline admission variables recorded were as follows: age, sex, duration of illness, primary diagnosis at admission, Pediatric Risk of Mortality III score, lung injury score, mechanical ventilation parameters, oxygenation indices, and duration of PICU stay...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29922788/photobiomodulation-prevents-dna-fragmentation-of-alveolar-epithelial-cells-and-alters-the-mrna-levels-of-caspase-3-and-bcl-2-genes-in-acute-lung-injury
#5
Luiz Philippe da Silva Sergio, Andrezza Maria Côrtes Thomé, Larissa Alexsandra da Silva Neto Trajano, Andre Luiz Mencalha, Adenilson de Souza da Fonseca, Flávia de Paoli
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are defined as pulmonary inflammation that could occur from sepsis and lead to pulmonary permeability and alveolar edema making them life-threatening diseases. Photobiomodulation (PBM) properties have been widely described in the literature in several inflammatory diseases; although the mechanisms of action are not always clear, this could be a possible treatment for ARDS/ALI. Thus, the aim of this study was to evaluate the mRNA levels from caspase-3 and BCL-2 genes and DNA fragmentation in lung tissue from Wistar rats affected by ALI and subjected to photobiomodulation by exposure to a low power infrared laser (808 nm; 100 mW; 3...
June 20, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29920152/selective-management-of-multiple-bronchopleural-fistulae-in-a-pediatric-patient-on-extracorporeal-membrane-oxygenation-a-multidisciplinary-approach
#6
Cory N Criss, Ryan Barbaro, Kristy Ann Bauman, Odetola Folafoluwa, Ranjith Vellody, Marcus D Jarboe
INTRODUCTION: This case highlights the successful utilization of a multidisciplinary approach to numerous bilateral bronchopleural fistulae (BPF) using minimally invasive techniques. In this study, we present a previously healthy 14-year-old male hospitalized with 2009 H1N1 influenza and methicillin-resistant Staphylococcus aureus coinfection complicated by severe acute respiratory distress syndrome and multifocal necrotizing pneumonia, with significant lung tissue damage requiring prolonged extracorporeal membrane oxygenation (ECMO) support...
June 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29916449/antinuclear-antibodies-in-scrub-typhus-transient-occurrence-during-acute-illness
#7
Maria Koshy, John Mathew, Reginald Alex, John Antony Jude, Ravikar Ralph, Thambu David Sudarsanam, Sowmya Sathyendra, J Visalakshi, John Victor Peter
Background & objectives: The pathological hallmark of scrub typhus infection is focal or disseminated vasculitis. As with other infections, antinuclear antibodies (ANA) have been previously described in scrub typhus. However, the underlying mechanisms and implications of this immunological phenomenon is not well understood. In the present work it was assessed whether ANA is associated with illness severity and outcomes. Methods: In this prospective study spanning one year, patients fulfilling the diagnostic criteria for scrub typhus were recruited...
January 2018: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29916441/epidemiology-drug-resistance-and-pathophysiology-of-plasmodium-vivax-malaria
#8
REVIEW
Kiran K Dayananda, Rajeshwara N Achur, D Channe Gowda
Malaria, caused by the protozoan parasites of the genus Plasmodium, is a major health problem in many countries of the world. Five parasite species namely, Plasmodium falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi, cause malaria in humans. Of these, P. falciparum and P. vivax are the most prevalent and account for the majority of the global malaria cases. In most areas of Africa, P. vivax infection is essentially absent because of the inherited lack of Duffy antigen receptor for chemokines on the surface of red blood cells that is involved in the parasite invasion of erythrocytes...
January 2018: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29914404/significantly-different-clinical-features-between-hypertriglyceridemia-and-biliary-acute-pancreatitis-a-retrospective-study-of-730-patients-from-a-tertiary-center
#9
Xiaoyao Li, Lu Ke, Jie Dong, Bo Ye, Lei Meng, Wenjian Mao, Qi Yang, Weiqin Li, Jieshou Li
BACKGROUND: Unlike western world, gallstones and hypertriglyceridemia (HTG) are among the first two etiologies of acute pancreatitis (AP) in China. But yet, detailed differences in clinical features and outcomes between hypertriglyceridemia and biliary acute pancreatitis have not been well described. METHODS: This retrospective study enrolled 730 acute pancreatitis patients from July 1, 2013 to October 1, 2016 in Jinling Hospital. The causes of the study patients were defined according to specific diagnostic criteria...
June 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29914229/effect-of-vitamin-d-deficiency-in-korean-patients-with-acute-respiratory-distress-syndrome
#10
Sojung Park, Min Gi Lee, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
Background/Aims: Vitamin D modulates innate and adaptive immune responses, and vitamin D deficiency is associated with increased mortality in hospitalized patients with pneumonia. We evaluated the prevalence of vitamin D deficiency in Korean patients with acute respiratory distress syndrome (ARDS) and its effect on the clinical outcomes of ARDS. Methods: We retrospectively analyzed the data of 108 patients who had a measured serum level of 25-hydroxy vitamin D3 (25(OH)D3) at the time of diagnosis with ARDS...
June 20, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29912110/understanding-macrophages-in-acute-respiratory-distress-syndrome-from-pathophysiology-to-precision-medicine
#11
Jean-Michel Constantin, Thomas Godet, Matthieu Jabaudon
No abstract text is available yet for this article.
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29911033/association-between-glycemic-gap-and-adverse-outcomes-in-critically-ill-patients-with-diabetes
#12
Sandeep Donagaon, Mala Dharmalingam
Objectives: Glycemic excursions are commonly seen in patients admitted to the Intensive Care Unit (ICU) and are related to adverse outcomes. Glycemic gap is a marker of this excursion in patients with diabetes. It can be used to predict adverse outcomes in patients with diabetes admitted to the ICU. It is calculated by subtracting A1C-derived average glucose (ADAG) = ([28.7 × HbA1c]-46.7) from plasma glucose at admission. Objective of this study was to correlate glycemic gap and adverse outcomes in patients with type 2 diabetes mellitus (DM) admitted to the ICU...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29908538/neutrophil-extracellular-traps-formation-and-involvement-in-disease-progression
#13
Sanni Kumar, Ena Gupta, Sanket Kaushik, Anupam Jyoti
Neutrophils are the forerunner in innate immunity by defending the host organisms against infectious pathogens. During such process, neutrophils reach the site of inflammation/infection and eliminate the pathogens by phagocytosis as well as by forming the neutrophil extracellular traps (NETs). NETs trap and eradicate a number of microbes including bacteria, fungi, protozoa, viruses. NETs consist of DNA which is decorated with histones and granular proteins such as neutrophil elastase (NE), gelatinase, myeloperoxidase...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29907273/extracorporeal-gas-exchange
#14
REVIEW
Onnen Moerer, Francesco Vasques, Eleonora Duscio, Francesco Cipulli, Federica Romitti, Luciano Gattinoni, Michael Quintel
Extracorporeal gas exchange is increasingly used for various indications. Among these are refractory acute respiratory failure, including the acute respiratory distress syndrome (ARDS), and the avoidance of ventilator-induced lung injury (VILI) by enabling lung-protective ventilation. Additionally, extracorporeal gas exchange allows the treatment of hypercapnic respiratory failure while helping to unload the respiratory muscles and avoid intubation and invasive ventilation, as well as facilitating weaning from the ventilator...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907269/determinants-and-prevention-of-ventilator-induced-lung-injury
#15
REVIEW
Francesco Vasques, Eleonora Duscio, Francesco Cipulli, Federica Romitti, Michael Quintel, Luciano Gattinoni
Ventilator-induced lung injury develops from interactions between the lung parenchyma and applied mechanical power. In acute respiratory distress syndrome, the lung is smaller size with an inhomogeneous structure. The same mechanical force applied on a reduced parenchyma would produce volutrauma; the concentration of mechanical forces at inhomogeneous interfaces produces atelectrauma. Higher positive end-expiratory pressures favor volutrauma and reduce atelectrauma; lower values do the opposite. Volutrauma and atelectrauma harms and benefits, however, seem to be equivalent at 5 to 15 cm H2 O...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907148/a-case-of-metaplastic-atrophic-gastritis-in-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-ipex-syndrome
#16
Youyou Luo, Jie Chen, Youhong Fang, Jingan Lou, Jindan Yu
BACKGROUND: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. CASE PRESENTATION: We present the case of a boy with metaplastic atrophic gastritis in whom immune dysregulation, polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome was confirmed by FOXP3 gene mutation...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29907087/factors-associated-with-missed-assessments-in-a-2-year-longitudinal-study-of-acute-respiratory-distress-syndrome-survivors
#17
Sara E Heins, Amy W Wozniak, Elizabeth Colantuoni, Kristin A Sepulveda, Pedro A Mendez-Tellez, Cheryl Dennison-Himmelfarb, Dale M Needham, Victor D Dinglas
BACKGROUND: To evaluate participant-related variables associated with missing assessment(s) at follow-up visits during a longitudinal research study. METHODS: This is a prospective, longitudinal, multi-site study of 196 acute respiratory distress syndrome (ARDS) survivors. More than 30 relevant sociodemographic, physical status, and mental health variables (representing participant characteristics prior to ARDS, at hospital discharge, and at the immediately preceding follow-up visit) were evaluated for association with missed assessments at 3, 6, 12, and 24-month follow-up visits (89-95% retention rates), using binomial logistic regression...
June 15, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29905558/urinary-malondialdehyde-as-a-predictive-and-diagnostic-marker-for-neonatal-acute-kidney-injury
#18
Y Hodovanets, A Babintseva, L Agafonova, O Makarova, A Frunza
Newborns are especially prone to oxidative stress (OS). Many free radical-mediated diseases have been described in newborns including bronchopulmonary dysplasia, respiratory distress syndrome, encephalopathy, and kidney injury. Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns. 67 critically sick full-term neonates were enrolled in the study including 31 newborns with AKI (group I) and 36 newborns without AKI (group II)...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904601/incidence-and-risk-factors-for-complications-after-definitive-skeletal-fixation-of-lower-extremity-in-multiple-injury-patients-a-retrospective-chart-review
#19
Thananit Sangkomkamhang, Wilaiphorn Thinkhamrop, Bandit Thinkhamrop, Wongsa Laohasiriwong
Background : The management of multiple injuries is complex. Type and timing of treatment for lower extremity fractures is a controversial subject. Although many studies have demonstrated the safety and effectiveness of early treatment, others have suggested that early definitive stabilization may cause complications, especially with chest and head injuries. The aim of this study was to determine the complications and effects of timing of fixation, and investigate risk factors for complications in multiple injuries patients with lower extremity fractures...
2018: F1000Research
https://www.readbyqxmd.com/read/29904430/expression-profile-of-micrornas-following-bone-marrow-derived-mesenchymal-stem-cell-treatment-in-lipopolysaccharide-induced-acute-lung-injury
#20
Joonhong Park, Sikyoung Jeong, Kicheol Park, Keumjin Yang, Soyoung Shin
Immunomodulatory or immunosuppressive properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) facilitate the treatment of acute respiratory distress syndrome and acute lung injury (ALI). Dysregulated miRNA (miRNA or miR) expression associated with the effects of BM-MSCs was assessed in a rat model of lipopolysaccharide (LPS)-induced ALI. The present study performed biochemical tests to assess five analytes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, blood urea nitrogen (BUN), and creatinine (CREA)...
June 2018: Experimental and Therapeutic Medicine
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