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Arterial stiffness

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https://www.readbyqxmd.com/read/28808067/childhood-socioeconomic-status-and-arterial-stiffness-in-adulthood-the-cardiovascular-risk-in-young-finns-study
#1
Elina Puolakka, Katja Pahkala, Tomi T Laitinen, Costan G Magnussen, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Päivi Tossavainen, Eero Jokinen, Matthew A Sabin, Tomi Laitinen, Marko Elovainio, Laura Pulkki-Råback, Jorma S A Viikari, Olli T Raitakari, Markus Juonala
Increasing evidence supports the importance of socioeconomic factors in the development of atherosclerotic cardiovascular disease. However, the association of childhood socioeconomic status (SES) with arterial stiffness in adulthood has not been reported. Our aim was to determine whether higher childhood family-level SES is associated with lower arterial stiffness in adulthood. The analyses were performed using data gathered within the longitudinal Young Finns Study. The sample comprised 2566 participants who had data concerning family SES at ages 3 to 18 years in 1980 and arterial pulse wave velocity and carotid artery distensibility measured 21 or 27 years later in adulthood...
August 14, 2017: Hypertension
https://www.readbyqxmd.com/read/28806778/serum-resistin-as-an-independent-marker-of-aortic-stiffness-in-patients-with-coronary-artery-disease
#2
Ji-Hung Wang, Chung-Jen Lee, Chiu-Fen Yang, Yu-Chih Chen, Bang-Gee Hsu
BACKGROUND: Subjects with higher carotid-femoral pulse wave velocity (cfPWV) will be at an increased risk for cardiovascular (CV) events in future. Resistin is an inflammatory mediator and a biomarker of CV diseases. We evaluated the association between serum resistin and aortic stiffness in patients with coronary artery disease (CAD). METHODS: A total of 104 patients with CAD were enrolled in this study. cfPWV was measured using the SphygmoCor system. Patients with cfPWV >10 m/s were defined as the high aortic stiffness group...
2017: PloS One
https://www.readbyqxmd.com/read/28802834/vegetable-derived-bioactive-nitrate-and-cardiovascular-health
#3
REVIEW
Catherine P Bondonno, Lauren C Blekkenhorst, Alex H Liu, Nicola P Bondonno, Natalie C Ward, Kevin D Croft, Jonathan M Hodgson
Vegetable derived nitrate is now recognised as an important bioactive phytochemical with cardioprotective properties. Nitrate, through the recently described enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, increases NO, a molecule pivotal for cardiovascular health. Clinical trials have observed that dietary nitrate has similar effects to NO when supplied exogenously. These effects include reduced blood pressure and improvements in other markers of vascular health such as endothelial function, arterial stiffness, ischemia reperfusion injury, blood flow, and platelet aggregation...
August 9, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28798782/evaluation-of-local-carotid-stiffness-and-inflammatory-biomarkers-in-stable-angina-pectoris
#4
Abdullah Nabi Aslan, Ayşe Nur Özcan, Hüseyin Ayhan, Serkan Sivri, Filiz Çelebi, Karabekir Ercan, Tahir Durmaz
INTRODUCTION: Arterial stiffness (AS) is a well-accepted and reliable predictor of atherosclerotic diseases. Inflammation plays an important role in the development of AS. AIM: To evaluate local carotid stiffness (CS) together with fibrinogen and high-sensitivity C-reactive protein (hsCRP) levels in stable angina pectoris (SAP) patients. MATERIAL AND METHODS: The study consisted of 353 consecutive patients with SAP. All underwent coronary angiography (CAG) after the evaluation of local CS parameters and carotid intima-media thickness (IMT) from both common carotid arteries by a real-time echo-tracking system...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28798074/the-influence-of-prenatal-exercise-and-pre-eclampsia-on-maternal-vascular-function
#5
REVIEW
Rachel J Skow, Emily C King, Craig D Steinback, Margie H Davenport
During healthy pregnancy, the cardiovascular system undergoes diverse adaptations to support adequate transfer of oxygen and nutrients from mother to fetus. In order to accommodate the large expansion of blood volume and associated cardiac output, the structure, mechanics, and function of the arteries are altered. Specifically, in healthy pregnancy there is a remodeling of arteries (increased angiogenesis and vasodilation), a generalized reduction in arterial stiffness (increased compliance), and an enhanced endothelial function...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28796934/predictors-of-candesartan-s-effect-on-vascular-reactivity-in-patients-with-coronary-artery-disease
#6
So-Ryoung Lee, In-Ho Chae, Hack-Lyoung Kim, Do-Yoon Kang, Sang-Hyun Kim, Hyo-Soo Kim
INTRODUCTION AND AIMS: Endothelial dysfunction and arterial stiffness have a prognostic value on adverse long-term outcomes in coronary artery disease (CAD) patients. We evaluated the efficacy on vascular reactivity of candesartan and analyzed predictors to control the candesartan's effect on vascular reactivity in CAD patients. METHOD: Patients were prospectively enrolled and prescribed candesartan for 6 months. The effect on vascular reactivity was evaluated by the change in flow-mediated dilation (FMD) and pulse wave velocity (PWV)...
August 10, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28794812/endovascular-management-of-superior-mesenteric-artery-sma-aneurysm-adequate-access-is-essential-for-success-case-report
#7
Lovro Tkalčić, Berislav Budiselić, Miljenko Kovačević, Siniša Knežević, Slavica Kovačić, Damir Miletić, Vjekoslav Tomulić, Dimitrij Kuhelj
BACKGROUND: An aneurysm of the superior mesenteric artery (SMA) with a diameter of 2.2 cm was found incidentally on an ultrasound (US) examination in a 26-year-old woman. The only known risk factor was an intracranial aneurysm that was found on her grandmother's autopsy. Based on pregnancy planning and the current literature, endovascular management with a covered stent was proposed. CASE REPORT: Self-expandable, covered stent (Bard, Fluency(®)) was implanted using a single transfemoral approach...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28794106/flow-mediated-dilation-and-peripheral-arterial-tonometry-are-disturbed-in-pre-eclampsia-and-reflect-different-aspects-of-endothelial-function
#8
Dominique Mannaerts, Ellen Faes, Inge Goovaerts, Tibor Stoop, Jerome Cornette, Wilfried Jozef Gyselaers, Marc E A Spaanderman, Emeline M Van Craenenbroeck, Yves Jacquemyn
BACKGROUND: Endothelial function and arterial stiffness are known to be altered in pre-eclamptic pregnancies. Previous studies have shown conflicting results regarding the best technique for assessing vascular function in pregnancy. In this study, we made a comprehensive evaluation of in vivo vascular function (including flow-mediated dilatation (FMD), peripheral arterial tonometry (PAT), and arterial stiffness) in pre-eclamptic patients and compared them to normal pregnancies. In addition, we assessed the relation between vascular function and systemic inflammation...
August 9, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28793219/stiff-substrates-increase-inflammation-induced-endothelial-monolayer-tension-and-permeability
#9
Rebecca Lownes Urbano, Christina Furia, Sarah Basehore, Alisa Morss Clyne
Arterial stiffness and inflammation are associated with atherosclerosis, and each have individually been shown to increase endothelial monolayer tension and permeability. The objective of this study was to determine if substrate stiffness enhanced endothelial monolayer tension and permeability in response to inflammatory cytokines. Porcine aortic endothelial cells were cultured at confluence on polyacrylamide gels of varying stiffness and treated with either tumor necrosis factor-α (TNFα) or thrombin. Monolayer tension was measured through vinculin localization at the cell membrane, traction force microscopy, and phosphorylated myosin light chain quantity and actin fiber colocalization...
August 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28792891/feasibility-and-validation-of-4-d-pulse-wave-imaging-in-phantoms-and-in-vivo
#10
Iason Z Apostolakis, Pierre Nauleau, Clement Papadacci, Matthew D McGarry, Elisa E Konofagou
Pulse wave Imaging (PWI) is a noninvasive technique for tracking the propagation of the pulse wave along the arterial wall. 3-D ultrasound imaging would aid in objectively estimating the PulseWave Velocity (PWV) vector. This study aims to introduce a novel PWV estimation method along the propagation direction, validate it in phantoms and test its feasibility in vivo. A silicone vessel phantom consisting of a stiff and a soft segment along the longitudinal axis and and a silicone vessel with a plaque were constructed...
August 3, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28791849/echocardiographic-assessment-and-n-terminal-pro-brain-natriuretic-peptide-in-hypertensives-with-metabolic-syndrome
#11
Paweł Krzesiński, Beata Uziebło-Życzkowska, Grzegorz Gielerak, Adam Stańczyk, Katarzyna Piotrowicz, Wiesław Piechota, Paweł Smurzyński, Andrzej Skrobowski
BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) release is associated with left ventricular expansion and pressure overload. Elevation of serum levels of natriuretic peptides is observed in patients with impaired as well as preserved left ventricular systolic function. High NT-proBNP has been shown to be related not only to preload but also to increased afterload, especially blood pressure and arterial stiffness. OBJECTIVES: The aim of the study was to evaluate the association of NT-proBNP and echocardiographic parameters in hypertensives with metabolic syndrome...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28787318/elevated-serum-osteoprotegerin-is-associated-with-increased-left-ventricular-mass-index-and-myocardial-stiffness
#12
Daisuke Kamimura, Takeki Suzuki, Anna L Furniss, Michael E Griswold, Iftikhar J Kullo, Merry L Lindsey, Michael D Winniford, Kenneth R Butler, Thomas H Mosley, Michael E Hall
AIM: Osteoprotegerin (OPG) is associated with a poor prognosis in patients with heart failure with preserved ejection fraction (HFpEF). OPG has also been associated with fibrosis and collagen cross-linking, which increase arterial and left ventricle (LV) myocardial stiffness. Little is known about the relation of OPG and LV structure and function in African-Americans who are disproportionately affected by HFpEF. METHODS AND RESULTS: Our analysis included 1172 participants with preserved LV ejection fraction (>50%) from the African-American cohort in the Genetic Epidemiology Network of Arteriopathy Study (mean age 63 years, 72% female)...
August 4, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28784855/ingesting-a-small-amount-of-beer-reduces-arterial-stiffness-in-healthy-humans
#13
Masato Nishiwaki, Naoki Kora, Naoyuki Matsumoto
Epidemiological studies reveal a J-shaped association between alcohol consumption and arterial stiffness, with arterial stiffening lower among mild-to-moderate drinkers than heavy drinkers or nondrinkers. This study aimed to examine the effects of ingesting a small amount of beer, corresponding to the amount consumed per day by a mild drinker, on arterial stiffness. Eleven men (20-22 years) participated, in random order and on different days, in four separate trials. The participants each drank 200 or 350 mL of alcohol-free beer (AFB200 and AFB350) or beer (B200 and B350), and were monitored for 90 min postingestion...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28784118/cardiovascular-riskprofile-imaging-and-gender-specific-disorders-crew-imago-rationale-and-design-of-a-multicenter-cohort-study
#14
Gerbrand A Zoet, Cindy Meun, Laura Benschop, Eric Boersma, Ricardo P J Budde, Bart C J M Fauser, Christianne J M de Groot, Aad van der Lugt, Angela H E M Maas, Karl G M Moons, Jeanine E Roeters van Lennep, Jolien W Roos-Hesselink, Eric A P Steegers, Bas B van Rijn, Joop S E Laven, Arie Franx, Birgitta K Velthuis
BACKGROUND: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD). Detection of early signs of cardiovascular disease (CVD), as well as identification of risk factors among women of reproductive age which improve cardiovascular risk prediction, is a challenge and current models might underestimate long-term health risks...
August 7, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28782135/ultrasound-evaluation-of-left-ventricular-and-aortic-fibrosis-after-pre-eclampsia
#15
Rossana Orabona, Edoardo Sciatti, Enrico Vizzardi, Ivano Bonadei, Federico Prefumo, Adriana Valcamonico, Marco Metra, Tiziana Frusca
OBJECTIVES: Myocardial fibrosis is linked with adverse clinical outcomes in adults. The objective was to investigate the presence of myocardial and/or aortic fibrosis in asymptomatic women with a history of early-onset (EO) or late-onset (LO) pre-eclampsia (PE) by echocardiographic calibrated integrated backscatter (cIBS). METHODS: 30 women who experienced pregnancies complicated by EOPE, 30 with a previous LOPE and 30 controls were retrospectively selected from our electronic database and then recalled from 6 months to 4 years after delivery...
August 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28780647/cardiovascular-responses-to-skeletal-muscle-stretching-stretching-the-truth-or-a-new-exercise-paradigm-for-cardiovascular-medicine
#16
REVIEW
Nicholas T Kruse, Barry W Scheuermann
Stretching is commonly prescribed with the intended purpose of increasing range of motion, enhancing muscular coordination, and preventing prolonged immobilization induced by aging or a sedentary lifestyle. Emerging evidence suggests that acute or long-term stretching exercise may modulate a variety of cardiovascular responses. Specifically, at the onset of stretch, the mechanical deformation of the vascular bed coupled with stimulation of group III muscle afferent fibers initiates a cascade of events resulting in both peripheral vasodilation and a heart rate-driven increase in cardiac output, blood pressure, and muscle blood flow...
August 5, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28780050/hesperidin-reverses-perivascular-adipose-mediated-aortic-stiffness-with-aging
#17
An Ouyang, Tyler B Garner, Bradley S Fleenor
We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were assessed in C57BL/6 mice that were young (6months), old (27-29months), or old treated with hesperidin for 4weeks. Old compared with young mice had increased aPWV (444±10 vs. 358±8cm/s, P<0.05) and mechanical stiffness (6506±369 vs...
August 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28778947/disturbed-flow-promotes-arterial-stiffening-through-thrombospondin-1-tsp-1
#18
Chan Woo Kim, Anastassia Pokutta-Paskaleva, Sandeep Kumar, Lucas H Timmins, Andrew D Morris, Dong-Won Kang, Sidd Dalal, Tatiana Chadid, Katie M Kuo, Julia Raykin, Haiyan Li, Hiromi Yanagisawa, Rudolph L Gleason, Hanjoong Jo, Luke P Brewster
Background -Arterial stiffness and wall shear stress are powerful determinants of cardiovascular health, and arterial stiffness is associated with increased cardiovascular mortality. Low and oscillatory wall shear stress, termed disturbed flow (d-flow), promotes atherosclerotic arterial remodeling, but the relationship between d-flow and arterial stiffness is not well understood. The objective of this study was to define the role of d-flow on arterial stiffening and discover the relevant signaling pathways by which d-flow stiffens arteries...
August 4, 2017: Circulation
https://www.readbyqxmd.com/read/28776083/diabetic-cardiomyopathy-a-hyperglycaemia-and-insulin-resistance-induced-heart-disease
#19
REVIEW
Guanghong Jia, Adam Whaley-Connell, James R Sowers
Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation abnormalities and later by clinical heart failure in the absence of dyslipidaemia, hypertension and coronary artery disease. Insulin resistance, hyperinsulinaemia and hyperglycaemia are each independent risk factors for the development of diabetic cardiomyopathy. The pathophysiological factors in diabetes that drive the development of cardiomyopathy include systemic metabolic disorders, inappropriate activation of the renin-angiotensin-aldosterone system, subcellular component abnormalities, oxidative stress, inflammation and dysfunctional immune modulation...
August 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28769817/suicidal-ideation-is-associated-with-altered-variability-of-fingertip-photo-plethysmogram-signal-in-depressed-patients
#20
Ahsan H Khandoker, Veena Luthra, Yousef Abouallaban, Simanto Saha, Khawza I U Ahmed, Raqibul Mostafa, Nayeefa Chowdhury, Herbert F Jelinek
Physiological and psychological underpinnings of suicidal behavior remain ill-defined and lessen timely diagnostic identification of this subgroup of patients. Arterial stiffness is associated with autonomic dysregulation and may be linked to major depressive disorder (MDD). The aim of this study was to investigate the association between arterial stiffness by photo-plethysmogram (PPG) in MDD with and without suicidal ideation (SI) by applying multiscale tone entropy (T-E) variability analysis. Sixty-one 10-min PPG recordings were analyzed from 29 control, 16 MDD patients with (MDDSI+) and 16 patients without SI (MDDSI-)...
2017: Frontiers in Physiology
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