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Arterial stiffness

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https://www.readbyqxmd.com/read/28227683/artsens-%C3%A2-mobile-a-portable-image-free-platform-for-automated-evaluation-of-vascular-stiffness
#1
Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam, Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam, T Aryasree, Mohanasankar Sivaprakasam, Jayaraj Joseph, Malay Ilesh Shah
Vascular stiffness is a key physiological marker significant in screening and early diagnosis of vascular disease. However, state of art techniques for vascular stiffness evaluation are not suited for field deployment. We present ARTSENS(®) Mobile, a portable, image-free ultrasound technology platform for automated evaluation of carotid artery stiffness, amenable for field deployment. The technology utilises a single element ultrasound transducer operated in pulse echo modality to investigate arterial wall dynamics, assisted by intelligent algorithms for wall identification and motion tracking to completely automate the measurement...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226511/characterization-of-thrombus-stiffening-in-radio-frequency-rf-mechanical-thrombectomy
#2
Chris C H Chon, Jack Z Qin, John C K Kwok, David C C Lam, Chris C H Chon, Jack Z Qin, John C K Kwok, David C C Lam, David Cc Lam, Chris Ch Chon, John Ck Kwok, Jack Z Qin
Intra-arterial mechanical thrombectomy (IAMT) for ischemic stroke has high recanalization rate, long treatment time window and low risk of symptomatic intracerebral haemorrhage (sICH), but thrombus fragments produced during treatment can lead to distal embolization. Fragmentation can be reduced if the thrombus is strengthened by increasing the thrombus's crosslink density. Radio frequency (rf) electric current commonly used in surgery to cut and coagulate tissue can induce crosslinking in thrombus. The increase in thrombus stiffness as a result of the increase in crosslinking from rf treatment is characterized in this study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226362/ambulatory-arterial-stiffness-indexes-in-cushing-s-syndrome
#3
Marialberta Battocchio, Andrea Rebellato, Andrea Grillo, Francesca Dassie, Pietro Maffei, Stella Bernardi, Bruno Fabris, Renzo Carretta, Francesco Fallo
Long-standing exposure to endogenous cortisol excess is associated with high cardiovascular risk. The aim of our study was to investigate arterial stiffness, which has been recognized as an independent predictor of adverse cardiovascular outcome, in a group of patients with Cushing's syndrome. Twenty-four patients with Cushing's syndrome (3 males, mean age 49±13 years; 20 pituitary-dependent Cushing's disease and 4 adrenal adenoma) underwent 24-h ambulatory blood pressure monitoring (ABPM) and evaluation of cardiovascular risk factors...
February 22, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28223468/high-ambulatory-arterial-stiffness-index-is-an-independent-risk-factor-for-rapid-age-related-glomerular-filtration-rate-decline-in-the-general-middle-aged-population
#4
Bjørn Odvar Eriksen, Vidar Tor Nyborg Stefansson, Trond Geir Jenssen, Ulla Dorte Mathisen, Jørgen Schei, Marit Dahl Solbu, Tom Wilsgaard, Toralf Melsom
Arterial stiffness is a risk factor for cardiovascular and chronic kidney disease. However, the role of arterial stiffness as a predictor of the age-related glomerular filtration rate (GFR) decline in the general population remains unresolved because of difficulty in measuring GFR with sufficient precision in epidemiological studies. The ambulatory arterial stiffness index (AASI) is a proposed indicator of arterial stiffness easily calculated from ambulatory blood pressure. We investigated whether AASI could predict GFR decline measured as iohexol clearance in the general population...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28222517/association-of-central-arterial-stiffness-and-pressure-pulsatility-with-mild-cognitive-impairment-and-dementia-the-atherosclerosis-risk-in-communities-study-neurocognitive-study-aric-ncs
#5
Michelle L Meyer, Priya Palta, Hirofumi Tanaka, Jennifer A Deal, Jacqueline Wright, David S Knopman, Michael Griswold, Thomas H Mosley, Gerardo Heiss
BACKGROUND: The association of central arterial stiffness and pressure pulsatility with mild cognitive impairment (MCI) and dementia is not well characterized in the population-based setting. OBJECTIVE: The aim of this study was to quantify the cross-sectional association of arterial stiffness and pressure pulsatility with MCI and dementia among 4,461 older white and black adults from the population-based Atherosclerosis Risk in Communities Study-Neurocognitive Study...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28220768/arterial-structure-and-function-in-subjects-with-acute-coronary-syndrome-after-one-year-of-treatment
#6
Agata Schneider, Joanna Gawęcka, Andrzej Minczykowski, Tomasz Krauze, Przemysław Guzik, Jarosław Piskorski, James Heathers, Andrzej Wykrętowicz
INTRODUCTION    It is controversial whether the modification of arterial stiffness and intima-media thickness (IMT) is plausible in patients with clinically significant atherosclerosis.  OBJECTIVES    We evaluated the effects of the one-year pharmacological therapy on the arterial stiffness and IMT in survivors of non-ST elevation myocardial infarction (NSTEMI) who were treated according to the clinical guidelines.  PATIENTS AND METHODS    For this study 298 NSTEMI patients (median age 64 years; 85 females) were enrolled...
February 15, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28219925/twenty-five-year-alcohol-consumption-trajectories-and-their-association-with-arterial-aging-a-prospective-cohort-study
#7
Darragh O'Neill, Annie Britton, Eric J Brunner, Steven Bell
BACKGROUND: Emerging evidence suggests that arterial stiffness, an important marker of cardiovascular health, is associated with alcohol consumption. However, the role of longer-term consumption patterns in the progression of arterial stiffness over time remains unclear. A longitudinal cohort design was used to evaluate the association between alcohol consumption over 25 years and subsequent changes in arterial stiffness. METHODS AND RESULTS: Data (N=3869; 73% male) were drawn from the Whitehall II cohort study of British civil servants, in which participants completed repeat pulse wave velocity assessments of arterial stiffness across a 4- to 5-year interval...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28211216/low-dose-eplerenone-treatment-decreases-aortic-stiffness-in-patients-with-resistant-hypertension
#8
Tatjana Kalizki, Bernhard M W Schmidt, Ulrike Raff, Annemarie Reinold, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Andreas Schneider
Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism has shown to provide effective blood pressure (BP)-control in patients with treatment resistant hypertension (TRH), but the concurrent effects on the vasculature have not been examined. In a randomized, double-blinded, placebo-controlled parallel-group study, 51 patients with TRH received either eplerenone 50 mg or placebo for 6 months together with additional antihypertensives titrated to achieve a BP target of <140/90 mm Hg...
February 17, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28210489/arterial-ventricular-coupling-and-parameters-of-vascular-stiffness-in-hypertensive-patients-role-of-gender
#9
Luca Faconti, Rosa Maria Bruno, Simona Buralli, Marta Barzacchi, Elisa Dal Canto, Lorenzo Ghiadoni, Stefano Taddei
OBJECTIVE: Non-invasive estimation of arterial-ventricular coupling has been extensively used for the evaluation of cardiovascular performance, however, a relative small amount of data is available regarding arterial-ventricular coupling and its components in hypertension. The present study was designed to investigate the relationship between left ventricular elastance, arterial elastance, parameters of vascular stiffness and the influence of gender in a population of hypertensive individuals...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28207773/local-versus-global-aortic-pulse-wave-velocity-in-early-atherosclerosis-an-animal-study-in-apoe-mice-using-ultrahigh-field-mri
#10
Alexander Gotschy, Wolfgang R Bauer, Patrick Winter, Peter Nordbeck, Eberhard Rommel, Peter M Jakob, Volker Herold
Increased aortic stiffness is known to be associated with atherosclerosis and has a predictive value for cardiovascular events. This study aims to investigate the local distribution of early arterial stiffening due to initial atherosclerotic lesions. Therefore, global and local pulse wave velocity (PWV) were measured in ApoE-/- and wild type (WT) mice using ultrahigh field MRI. For quantification of global aortic stiffness, a new multi-point transit-time (TT) method was implemented and validated to determine the global PWV in the murine aorta...
2017: PloS One
https://www.readbyqxmd.com/read/28207187/a-robust-method-to-generate-mechanically-anisotropic-vascular-smooth-muscle-cell-sheets-for-vascular-tissue-engineering
#11
Daniel E Backman, Bauer L LeSavage, Shivem B Shah, Joyce Y Wong
In arterial tissue engineering, mimicking native structure and mechanical properties is essential because compliance mismatch can lead to graft failure and further disease. With bottom-up tissue engineering approaches, designing tissue components with proper microscale mechanical properties is crucial to achieve the necessary macroscale properties in the final implant. This study develops a thermoresponsive cell culture platform for growing aligned vascular smooth muscle cell (VSMC) sheets by photografting N-isopropylacrylamide (NIPAAm) onto micropatterned poly(dimethysiloxane) (PDMS)...
February 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28202946/association-of-serum-uric-acid-with-subsequent-arterial-stiffness-and-renal-function-in-normotensive-subjects
#12
Shiori Nagano, Maasa Takahashi, Nobuyuki Miyai, Mayumi Oka, Miyoko Utsumi, Mitsuru Shiba, Kanae Mure, Tatsuya Takeshita, Mikio Arita
Serum uric acid (SUA) is correlated with an increased risk of not only gout but also cardiovascular diseases. The present study aimed to longitudinally evaluate the effects of SUA level on renal function and arterial stiffness in a population-based sample of normotensive subjects. The subjects completed a health checkup in 2002 at baseline and in 2011 or 2012 at the end of the follow-up period. A total of 407 normotensive subjects (171 men and 236 women) aged 26-66 years were enrolled in this study. We measured blood pressure (BP), brachial-ankle pulse wave velocity (baPWV), central BP, intima-media thickness, SUA level and estimated glomerular filtration rate (eGFR)...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28202944/controversies-in-the-association-of-cardiorespiratory-fitness-and-arterial-stiffness-in-children-and-adolescents
#13
Joanna Meyer, Julia Elmenhorst, Tobias Giegerich, Renate Oberhoffer, Jan Müller
The relationship between cardiorespiratory fitness and arterial compliance in children and adolescents remains controversial. The aim of this study was to assess this association with a quantitative approach. A total of 646 healthy children and adolescents (316 females, age 13.9±2.1 years) were cross-sectionally investigated in seven school settings in and around Munich for their cardiorespiratory fitness and demographic, anthropometric and hemodynamic parameters. Surrogates of arterial stiffness, such as pulse wave velocity (PWV), Augmentation Index normalized to a heart rate of 75 (AI@75), and peripheral and central systolic blood pressures were measured in a supine position using the oscillometric Mobil-O-Graph...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28198819/beat-to-beat-blood-pressure-and-two-dimensional-axial-and-radial-motion-of-the-carotid-artery-wall-physiological-evaluation-of-arterial-stiffness
#14
Chenchu Xu, Huahua Xiong, Zhifan Gao, Xin Liu, Heye Zhang, Yanping Zhang, Xiuquan Du, Wanqing Wu, Guotao Liu, Shuo Li
The physiological relationship between local arterial displacement and blood pressure (BP) plays an integral role in assess- ment of the mechanical properties of arteries. In this study, we used more advanced methods to obtain reliable continuous BP and the displacement of the common carotid artery (CCA) simultaneously. We propose a novel evaluation method for arterial stiffness that relies on determining the physiological relationship between the axial and radial displacements of the CCA wall and beat-to-beat BP...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197292/chlorthalidone-plus-amiloride-reduces-the-central-systolic-blood-pressure-in-stage-1-hypertension-patients
#15
Leticia Aparecida Barufi Fernandes, Elizabeth do Espirito Santo Cestario, Luciana Neves Cosenso-Martin, Jose Fernando Vilela-Martin, Juan Carlos Yugar-Toledo, Flavio Danni Fuchs
BACKGROUND: Hypertension reduction strategies use blood pressure in the brachial artery as the primary endpoint. Individuals who achieve the target blood pressure reduction with antihypertensive treatment have residual cardiovascular risk attributed to the difference in pressure between the aorta and brachial artery. Antihypertensive treatment affects the intrinsic properties of the vascular wall and arterial stiffness markers and consequently the central pressure. Recent publications stress the importance of adequate control of the central compared to peripheral blood pressure...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28196818/association-of-morning-hypertension-subtype-with-vascular-target-organ-damage-and-central-hemodynamics
#16
Jaewon Oh, Chan Joo Lee, In-Cheol Kim, Sang-Hak Lee, Seok-Min Kang, Donghoon Choi, Sungha Park, Kazuomi Kario
BACKGROUND: A recent study reported that morning hypertension is associated with poor cardiovascular outcomes in hypertensive patients. However, it is unclear whether morning hypertension associated with sustained nocturnal hypertension and that associated with morning blood pressure (BP) surge differ in terms of their effects on cardiovascular target organ damage and clinical outcomes. The present study aimed to determine the association of morning hypertension with/without nocturnal hypertension with vascular target organ damage and central hemodynamics in patients at high risk for cardiovascular disease...
February 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28195999/clinical-significance-of-arterial-stiffness-and-metabolic-syndrome-scores-in-vestibular-neuritis
#17
Jae Ho Chung, Seung Hwan Lee, Chul Won Park, Jin Hyeok Jeong, Jeong-Hun Shin
OBJECTIVE: To investigate the clinical significance of cardiovascular factors, including arterial stiffness and metabolic syndrome scores, in the development of vestibular neuritis. STUDY DESIGN: A prospective, case-control study. SETTING: Tertiary referral center. PATIENTS: Fifty-eight adult patients with vestibular neuritis (VN) and 58 age- and sex-matched controls were evaluated between January 2015 and January 2016...
February 10, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28195589/preterm-arteries-in-childhood-dimensions-intima-media-thickness-and-elasticity-of-the-aorta-coronaries-and-carotids-in-6-y-old-children-born-extremely-preterm
#18
Lilly-Ann Mohlkert, Jenny Hallberg, Olof Broberg, Monica Hellström, Cecilia Pegelow Halvorsen, Gunnar Sjöberg, Anna-Karin Edstedt Bonamy, Petru Liuba, Vineta Fellman, Magnus Domellöf, Mikael Norman
BACKGROUND: Preterm birth increases risk for adult cardiovascular disease. We hypothesized that arteries in 6-y-old children born preterm are narrower, with thicker intima-media and stiffer than in peers born at term. METHODS: Children born extremely preterm (EXP, n = 176, birthweights: 348-1,161 g) and at term (CTRL, n = 174, birthweights: 2,430-4,315 g) were included. Using ultrasonography, we determined diameters of the coronaries (CA), common carotid arteries (CCA) and aorta, the carotid intima media thickness (cIMT), and the stiffness index of the CCA and aorta...
February 2017: Pediatric Research
https://www.readbyqxmd.com/read/28194861/association-between-reduced-arterial-stiffness-and-preserved-diastolic-function-of-the-left-ventricle-in-middle-aged-and-elderly-patients
#19
Kyung-Taek Park, Hack-Lyoung Kim, Sohee Oh, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
The aim of this study was to investigate whether arterial stiffness plays a role in retaining normal diastolic function in a middle-aged and elderly Korean population. A total of 267 patients without documented cardiovascular disease, 50 years and older (mean age, 57.3±6.3 years; 69.8% men) were retrospectively analyzed. All patients underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity measurement on the same day. Patients with septal annular peak velocity (e') ≥8 cm/s and left atrial volume index <34 mL/m(2) were considered as having normal diastolic function...
February 13, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28194660/a-novel-apparatus-for-the-multifaceted-evaluation-of-arterial-function-through-transmural-pressure-manipulation
#20
Toshiyuki Yaguchi, Yalin Cong, Kenji Shimo, Takahiro Kurokawa, Shukei Sugita, Kazuaki Nagayama, Hiroshi Masuda, Takeo Matsumoto
A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC)...
February 13, 2017: Annals of Biomedical Engineering
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