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https://www.readbyqxmd.com/read/28267899/-risk-stratification-based-on-magnetic-resonance-imaging-and-prostate-specific-antigen-density-may-reduce-unnecessary-follow-up-biopsy-procedures-in-men-on-active-surveillance-for-low-risk-prostate-cancer
#1
Arnout R Alberts, Monique J Roobol, Frank-Jan H Drost, Geert J van Leenders, Leonard P Bokhorst, Chris H Bangma, Ivo G Schoots
OBJECTIVES: To assess the value of risk-stratification based on magnetic resonance imaging (MRI) and prostate-specific antigen (PSA) density in reducing unnecessary biopsies without missing Gleason pattern 4 prostate cancer (PCa) in men on active surveillance. MATERIALS AND METHODS: A total of 210 men on active surveillance with GS 3+3 PCa received a first MRI and if indicated (PI-RADS ≥3) targeted biopsy (TBx) using MRI-TRUS fusion. The MRI was performed 3 months after diagnosis (group A: n=97), at confirmatory biopsy (group B: n=39) or at surveillance biopsy after ≥1 repeat TRUS-guided systematic biopsies (TRUS-Bx) (group C: n=74)...
March 7, 2017: BJU International
https://www.readbyqxmd.com/read/28256901/diagnosis-of-typical-and-atypical-transitional-zone-prostate-cancer-and-its-mimics-at-multiparametric-prostate-mri
#2
Jinxing Yu, Ann S Fulcher, Sarah G Winks, Mary A Turner, Ryan D Clayton, Michael Brooks, Sean Li
Many of the current clinical screening methods for prostate cancer (PCa) such as prostate specific antigen (PSA) testing or trans-rectal ultrasound (TRUS)-guided prostate biopsy lack sensitivity and specificity for diagnosis of PCa of the transition zone (TZ). Recent technical advances in multiparametric-MRI (mp-MRI) have markedly improved detection of PCa of the TZ. However, there are many diagnostic challenges we still encounter in our daily practice that compromise the accuracy of the diagnosis. By performing both MRI-guided and US/MRI fusion-guided biopsies, we have gained extensive experience in the diagnosis of PCa of the TZ...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28238758/pathological-findings-in-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-relation-to-prostate-cancer-focal-therapy
#3
REVIEW
Jennifer Gordetsky, Soroush Rais-Bahrami, Jonathan I Epstein
The introduction of widespread prostate-specific antigen screening brought about an increase in the detection of clinically low-risk prostate cancer. Many of these patients are overtreated by radical prostatectomy and radiation. Comparatively, focal therapy for prostate cancer offers the advantage of decreased rates of incontinence and impotence. The 12-core extended sextant transrectal ultrasound-guided needle biopsy is unable to safely identify candidates for focal therapy. Multiparametric magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsy can detect more clinically significant prostate cancers and aid in accurate detection of higher-grade disease...
February 24, 2017: Urology
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#4
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28225639/cost-effectiveness-comparison-of-imaging-guided-prostate-biopsy-techniques-systematic-transrectal-ultrasound-direct-in-bore-mri-and-image-fusion
#5
Wulphert Venderink, Tim M Govers, Maarten de Rooij, Jurgen J Fütterer, J P Michiel Sedelaar
OBJECTIVE: Three commonly used prostate biopsy approaches are systematic transrectal ultrasound guided, direct in-bore MRI guided, and image fusion guided. The aim of this study was to calculate which strategy is most cost-effective. MATERIALS AND METHODS: A decision tree and Markov model were developed to compare cost-effectiveness. Literature review and expert opinion were used as input. A strategy was deemed cost-effective if the costs of gaining one quality-adjusted life year (incremental cost-effectiveness ratio) did not exceed the willingness-to-pay threshold of €80,000 (≈$85,000 in January 2017)...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#6
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28220802/the-prostate-cancer-prevention-trial-risk-calculator-2-0-performs-equally-for-standard-biopsy-and-mri-us-fusion-guided-biopsy
#7
M Maruf, M Fascelli, A K George, M M Siddiqui, M Kongnyuy, J M DiBianco, A Muthigi, S Valayil, A Sidana, T P Frye, A Kilchevsky, P L Choyke, B Turkbey, B J Wood, P A Pinto
BACKGROUND: The Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPTRC) is a widely used risk-based calculator used to assess a man's risk of prostate cancer (PCa) before biopsy. This risk calculator was created from data of a patient cohort undergoing a 6-core sextant biopsy, and subsequently validated in men undergoing 12-core systematic biopsy (SBx). The accuracy of the PCPTRC has not been studied in patients undergoing magnetic resonance imaging/ultrasound (MRI/US) fusion-guided biopsy (FBx)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28216939/prostatic-intraepithelial-neoplasia-like-ductal-prostatic-adenocarcinoma-a-case-suitable-for-active-surveillance
#8
Soroush Rais-Bahrami, Melissa R Dillard, Grace G Zhu, Jennifer B Gordetsky
In contrast to typical prostatic ductal adenocarcinoma, prostatic intraepithelial neoplasia (PIN)-like ductal adenocarcinoma is a rare variant of prostate cancer with low-grade clinical behavior. We report a case of a 66-year-old African-American male with an elevated serum prostate-specific antigen who underwent multiparametric prostate magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsies. Pathology demonstrated low-volume Gleason score 3 + 3 = 6 (Grade Group 1), acinar adenocarcinoma involving one core and PIN-like ductal adenocarcinoma on a separate core...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28179286/italian-prostate-biopsies-group-2016-updated-guidelines-insights
#9
REVIEW
Andrea Fandella, Vincenzo Scattoni, Andrea Galosi, Pietro Pepe, Michelangelo Fiorentino, Caterina Gaudiano, Marco Giampaoli, Roberta Gunelli, Pasquale Martino, Vittorino Montanaro, Rodolfo Montironi, Tiziana Pierangeli, Armando Stabile, Alessandro Bertaccini
AIM: To present a summary of the updated guidelines of the Italian Prostate Biopsies Group following the best recent evidence of the literature. MATERIALS AND METHODS: A systematic review of the new data emerging from 2012-2015 was performed by a panel of 14 selected Italian experts in urology, pathology and radiology. The experts collected articles published in the English-language literature by performing a search using Medline, EMBASE and the Cochrane Library database...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28163032/impact-of-gleason-subtype-on-prostate-cancer-detection-using-multiparametric-mri-correlation-with-final-histopathology
#10
Matthew Truong, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Our purpose was to determine whether Gleason pattern 4 architecture impacts tumor visibility on multiparametric (mpMRI) and correlate with final histopathology. MATERIALS AND METHODS: A total of 83 tumor foci were identified within 22 radical prostatectomy specimens from patients with a prior negative biopsy who underwent MR/US fusion biopsy followed by radical prostatectomy from January 2015-July 2016. A genitourinary pathologist re-reviewed tumor foci for Gleason architectural subtype...
February 2, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28159491/the-role-of-magnetic-resonance-image-guided-prostate-biopsy-in-stratifying-men-for-risk-of-extracapsular-extension-at-radical-prostatectomy-raskolnikov-d-george-ak-rais-bahrami-s-turkbey-b-siddiqui-mm-shakir-na-okoro-c-rothwax-jt-walton-diaz-a-sankineni-s-su
#11
Eggener Scott
PURPOSE: Magnetic resonance imaging detects extracapsular extension by prostate cancer with excellent specificity but low sensitivity. This limits surgical planning, which could be modified to account for focal extracapsular extension with image directed guidance for wider excision. In this study, we evaluate the performance of multiparametric magnetic resonance imaging in extracapsular extension detection and determine which preoperative variables predict extracapsular extension on final pathology when multiparametric magnetic resonance imaging predicts organ confined disease...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28140460/factors-predicting-prostate-cancer-upgrading-on-magnetic-resonance-imaging-targeted-biopsy-in-an-active-surveillance-population
#12
Win Shun Lai, Jennifer B Gordetsky, John V Thomas, Jeffrey W Nix, Soroush Rais-Bahrami
BACKGROUND: The objective of this study was to create a nomogram model integrating clinical and multiparametric magnetic resonance imaging (MP-MRI)-based variables to predict prostate cancer upgrading in a population of active surveillance (AS) patients. METHODS: Prostate cancer patients on AS who underwent MP-MRI with magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided biopsy were identified. Clinical and imaging variables, including the prostate-specific antigen density (PSAD), number of lesions, total lesion volume, total lesion density, Prostate Imaging Reporting and Data System magnetic resonance imaging suspicion score (MRI-SS), and duration between prereferral systematic and MRI/US fusion-guided biopsy sessions, were assessed...
January 31, 2017: Cancer
https://www.readbyqxmd.com/read/28126217/prostate-mr-imaging-an-update
#13
REVIEW
Hiram Shaish, Samir S Taneja, Andrew B Rosenkrantz
Improvements in prostate MR imaging techniques and the introduction of MR imaging-targeted biopsies have had central roles in prostate cancer (PCa) management. The role of MR imaging has progressed from largely staging patients with biopsy-proven PCa to detecting, characterizing, and guiding the biopsy of suspected PCa. These diagnostic advances, combined with improved therapeutic interventions, have led to a more sophisticated and individually tailored approach to patients' unique PCa profile. This review discusses the MR imaging, a standardized reporting scheme, and the role of fusion-targeted prostate biopsy...
March 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28115952/salvage-high-dose-rate-brachytherapy-for-histologically-confirmed-macroscopic-local-relapsed-prostate-cancer-after-radical-prostatectomy
#14
David Buchser, Alfonso Gomez-Iturriaga, J Ignacio Rodriguez Melcon, Francisco Casquero, Roberto Llarena, Jon Cacicedo, Pedro Bilbao
PURPOSE: To evaluate the feasibility of the use of real-time magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) fusion guided high-dose-rate brachytherapy (HDR-BT) +/- external beam radiation therapy (EBRT) in patients with histologically-proven local relapse after radical prostatectomy. MATERIAL AND METHODS: We retrospectively reviewed 13 patients treated with real-time MRI-TRUS fusion HDR-BT for a local relapse of prostate cancer after radical surgery...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28111879/detection-of-prostate-cancer-using-magnetic-resonance-imaging-ultrasonography-image-fusion-targeted-biopsy-in-african-american-men
#15
Toshitaka Shin, Thomas B Smyth, Osamu Ukimura, Nariman Ahmadi, Andre Luis de Castro Abreu, Masakatsu Oishi, Hiromitsu Mimata, Inderbir S Gill
OBJECTIVE: To assess the diagnostic yield of targeted prostate biopsy in African-American (A-A) men using image fusion of multi-parametric magnetic resonance imaging (mpMRI) with real-time transrectal ultrasonography (US). PATIENTS AND METHODS: We retrospectively analysed 661 patients (117 A-A and 544 Caucasian) who had mpMRI before biopsy and then underwent MRI/US image-fusion targeted biopsy (FTB) between October 2012 and August 2015. The mpMRIs were reported on a 5-point Likert scale of suspicion...
January 23, 2017: BJU International
https://www.readbyqxmd.com/read/28093292/multiparametric-magnetic-resonance-ultrasound-fusion-prostate-biopsy-number-and-spatial-distribution-of-cores-for-a-better-index-tumor-detection-and-characterization
#16
Francesco Porpiglia, Stefano De Luca, Roberto Passera, Agostino De Pascale, Daniele Amparore, Giovanni Cattaneo, Enrico Checcucci, Sabrina De Cillis, Diletta Garrou, Matteo Manfredi, Fabrizio Mele, Enrico Bollito, Cristian Fiori
PURPOSE: to evaluate the minimum cores number for a better index tumor detection, to investigate the best core site and biopsy Gleason Score (GS) heterogeneity within the same index lesion, to optimize the highest GS detection. MATERIALS AND METHODS: 327 patients with negative DRE underwent MRI/TRUS fusion targeted biopsy (TBx) for elevated/rising PSA, and/or ≥1 detectable lesions at multiparametric MRI after previous negative standard biopsy. Depending on the diameter of each index lesion, ≤8 or > 8 mm, four or six cores were taken respectively, according to a well-determined sequence...
January 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28093146/re-magnetic-resonance-imaging-ultrasound-fusion-biopsy-during-prostate-cancer-active-surveillance
#17
Samir S Taneja
No abstract text is available yet for this article.
February 2017: Journal of Urology
https://www.readbyqxmd.com/read/28086856/the-addition-of-a-sagittal-image-fusion-improves-the-prostate-cancer-detection-in-a-sensor-based-mri-ultrasound-fusion-guided-targeted-biopsy
#18
Karsten Günzel, Hannes Cash, John Buckendahl, Maximilian Königbauer, Patrick Asbach, Matthias Haas, Jörg Neymeyer, Stefan Hinz, Kurt Miller, Carsten Kempkensteffen
BACKGROUND: To explore the diagnostic benefit of an additional image fusion of the sagittal plane in addition to the standard axial image fusion, using a sensor-based MRI/US fusion platform. METHODS: During July 2013 and September 2015, 251 patients with at least one suspicious lesion on mpMRI (rated by PI-RADS) were included into the analysis. All patients underwent MRI/US targeted biopsy (TB) in combination with a 10 core systematic prostate biopsy (SB). All biopsies were performed on a sensor-based fusion system...
January 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28074780/mri-directed-cognitive-fusion-guided-biopsy-of-the-anterior-prostate-tumors
#19
Ian G Murphy, Elaine NiMhurchu, Robert G Gibney, Colm J McMahon
PURPOSE: We aimed to evaluate the efficacy of magnetic resonance imaging (MRI)-directed cognitive fusion transrectal ultrasonography (TRUS)-guided anterior prostate biopsy for diagnosis of anterior prostate tumors and to illustrate this technique. METHODS: A total of 39 patients with previous negative TRUS biopsy, but high clinical suspicion of occult prostate cancer, prospectively underwent prostate MRI including diffusion-weighted imaging (DWI). Patients with a suspicious anterior lesion on MRI underwent targeted anterior gland TRUS-guided biopsy with cognitive fusion technique using sagittal probe orientation...
March 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28073197/detection-rate-for-significant-cancer-at-confirmatory-biopsy-in-men-enrolled-in-active-surveillance-protocol-20-cores-vs-30-cores-vs-mri-trus-fusion-prostate-biopsy
#20
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Barbera, Paolo Panella, Michele Pennisi, Giuseppe Morgia
INTRODUCTION: The detection rate for significant prostate cancer of extended vs saturation vs mMRI/TRUS fusion biopsy was prospectively evaluated in men enrolled in active surveillance (AS) protocol. Mterials and methods: From May 2013 to September 2016 75 men aged 66 years (median) with very low risk PCa were enrolled in an AS protocol and elegible criteria were: life expectancy greater than 10 years, cT1C, PSA below 10 ng/ml, PSA density < 0.20, 2 < unilateral positive biopsy cores, Gleason score (GS) equal to 6, greatest percentage of cancer (GPC) in a core < 50%...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
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