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Fusion biopsy prostate

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https://www.readbyqxmd.com/read/28531902/evaluation-of-prostate-imaging-reporting-and-data-system-classification-in-the-prediction-of-tumor-aggressiveness-in-targeted-magnetic-resonance-imaging-ultrasound-fusion-biopsy
#1
Angelika Borkowetz, Ivan Platzek, Marieta Toma, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo B Baretton, Michael Froehner, Stefan Zastrow, Manfred P Wirth
OBJECTIVES: The study aimed to evaluate the prediction of Prostate Imaging Reporting and Data System (PI-RADS) with respect to the prostate cancer (PCa) detection rate and tumor aggressiveness in magnetic resonance imaging (MRI)/ultrasound-fusion-biopsy (fusPbx) and in systematic biopsy (sysPbx). MATERIALS AND METHODS: Six hundred and twenty five patients undergoing multiparametric MRI were investigated. MRI findings were classified using PI-RADS v1 or v2. All patients underwent fusPbx combined with sysPbx (comPbx)...
May 23, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28514203/cost-effectiveness-of-mr-imaging-guided-strategies-for-detection-of-prostate-cancer-in-biopsy-naive-men
#2
Shivani Pahwa, Nicholas K Schiltz, Lee E Ponsky, Ziang Lu, Mark A Griswold, Vikas Gulani
Purpose To evaluate the cost-effectiveness of multiparametric diagnostic magnetic resonance (MR) imaging examination followed by MR imaging-guided biopsy strategies in the detection of prostate cancer in biopsy-naive men presenting with clinical suspicion of cancer for the first time. Materials and Methods A decision-analysis model was created for biopsy-naive men who had been recommended for prostate biopsy on the basis of abnormal digital rectal examination results or elevated prostate-specific antigen levels (age groups: 41-50 years, 51-60 years, and 61-70 years)...
May 17, 2017: Radiology
https://www.readbyqxmd.com/read/28513296/confirmatory-biopsy-of-men-under-active-surveillance-extended-versus-saturation-versus-multiparametric-magnetic-resonance-imaging-transrectal-ultrasound-fusion-prostate-biopsy
#3
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Pennisi, Giuseppe Morgia
OBJECTIVE: The aim of this study was to evaluate the detection rate for clinically significant prostate cancer (PCa) after multiparametric magnetic resonance imaging (mpMRI)/transrectal ultrasound (TRUS) fusion biopsy versus extended biopsy or saturation prostate biopsy (SPBx) in men enrolled on active surveillance (AS). MATERIALS AND METHODS: From May 2013 to January 2016, 100 men with very low-risk PCa were enrolled on AS. Eligible criteria were: life expectancy greater than 10 years, cT1c, prostate-specific antigen (PSA) below 10 ng/ml, PSA density less than 0...
May 17, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28508759/mri-trus-fusion-for-electrode-positioning-during-irreversible-electroporation-for-treatment-of-prostate-cancer
#4
Alexander D J Baur, Federico Collettini, Judith Enders, Andreas Maxeiner, Vera Schreiter, Carsten Stephan, Bernhard Gebauer, Bernd Hamm, Thomas Fischer
We aimed to introduce an approach for image-guided positioning of electrodes for irreversible electroporation (IRE) in patients with prostate cancer using a magnetic resonance imaging-transrectal ultrasonography (MRI-TRUS) fusion technique. In 10 consecutive patients with biopsy-proven Gleason score ≤3+4 prostate cancer, 19 G electrodes were inserted into the prostate using a transperineal access. Magnetic resonance images of the prostate acquired before IRE were fused with transrectal ultrasound images acquired during IRE...
May 15, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28507619/expression-of-erg-protein-and-tmrpss2-erg-fusion-in-prostatic-carcinoma-in-egyptian-patients
#5
Ahmed Abdel-Hady, Ali El-Hindawi, Olfat Hammam, Heba Khalil, Sara Diab, Soulafa Abd El-Aziz, Mohamed Badawy, Ahmed Ismail, Noha Helmy, Nora Kamel, Shady Anis, Amr El Kholy, Khalid Al Osili, Afaf Abdel-Hady, Hani Nour, Maha Akl
AIM: Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and its rearrangement could give us clues for proper identification of PCa. And the study of ERG expression and its comparison to FISH in Egyptian patients can show whether ERG immunophenotype could be used instead of FISH, as it is cheaper. MATERIALS AND METHODS: This study was performed on 85 cases of PCa, showing 30 cases with HGPIN and 30 cases of prostatic hyperplasia...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28502474/-role-of-prostate-mri-trus-fusion-biopsies-and-new-markers-in-the-diagnostic-strategy-of-prostate-cancer
#6
Raphaële Renard-Penna, Pierre Mozer, Luca Lunelli, Olivier Cussenot
Multiparametric MRI prostate (mp-MRI) is a powerful tool to locate lesions>0.5cm(3) (below this threshold tumor volume, prostate cancers are classified as "insignificant"). The detection rate of the mp-MRI for significant cancers of small volume (0.5-1cm(3)) with a Gleason score≥7 is>85 %. The prostate mp-MRI optimizes the management of cancers classified as low risk of progression by providing aggressive criteria for misclassified lesions, which require an active treatment and enhance the clinicopathological criteria of indolence for subclinical lesions, which can justify of surveillance...
May 11, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28501565/prostate-zonal-anatomy-correlates-with-the-detection-of-prostate-cancer-on-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-targeted-biopsy-in-patients-with-a-solitary-pi-rads-v2-scored-lesion
#7
Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, Ansh M Bhagat, Steffen Huber, Angelique Levi, Peter Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
PURPOSE: To evaluate the positive predictive value (PPV) of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) assessment method in patients with a single suspicious finding on prostate multiparametric magnetic resonance imaging (mpMRI). PATIENTS AND METHODS: A total of 176 patients underwent MRI/ultrasound fusion-targeted prostate biopsy after the detection of a single suspicious finding on mpMRI. The PPV for cancer detection was determined based on PI-RADS v2 assessment score and location...
May 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28488844/mri-in-prostate-cancer-detection-and-management-a-systematic-review
#8
Fabio Monni, Paolo Fontanella, Angelica Grasso, Peter Wiklund, Yen-Chuan Ou, Marco Randazzo, Bernardo Rocco, Emanuele Montanari, Giampaolo Bianchi
INTRODUCTION: The aim of our work was to evaluate the role of multi-parametric MRI (mpMRI) in detection and management of prostate cancer (PC); specifically investigating the efficacy of mpMRI-based biopsy techniques in terms of diagnostic yield of significant prostate neoplasm and the improved management of patient who choose conservative treatments or active surveillance. EVIDENCE ACQUISITION: A systematic and critical analysis through Medline, Embase, Scopus and Web of Science databases was carried out in March 2016, following the PRISMA ("Preferred Reporting Items for Systematic Reviews and Meta-Analyses") statement...
May 8, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28469301/multiparametric-magnetic-resonance-imaging-transrectal-ultrasound-fusion-prostate-biopsy-a-prospective-single-centre-study
#9
Somendra Bansal, Narmada P Gupta, Rajiv Yadav, Rakesh Khera, Kulbir Ahlawat, Dheeraj Gautam, Rajesh Ahlawat, Gagan Gautam
INTRODUCTION: Transrectal rectal ultrasound (TRUS)-guided systematic biopsy is the gold standard for diagnosis of prostate cancer. However, systematic biopsy has high false-negative rate and often misses anteriorly located tumors. Magnetic resonance imaging (MRI)-TRUS fusion biopsy can potentially improve cancer detection by better visualization and targeting of cancer focus. We evaluated the role of fusion biopsy in detection of prostate cancer and the association of prostate imaging reporting and data system (PI-RADS) score for predicting cancer risk and its aggression...
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28451763/evaluating-the-performance-of-pi-rads-v2-in-the-non-academic-setting
#10
Eric J Jordan, Charles Fiske, Ronald J Zagoria, Antonio C Westphalen
PURPOSE: To evaluate the utility of PI-RADS v2 to diagnose clinically significant prostate cancer (CS-PCa) with magnetic resonance ultrasound (MR/US) fusion-guided prostate biopsies in the non-academic setting. MATERIALS/METHODS: Retrospective analysis of men whom underwent prostate multiparametric MRI and subsequent MR/US fusion biopsies at a single non-academic center from 11/2014 to 3/2016. Prostate MRIs were performed on a 3-Tesla scanner with a surface body coil...
April 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28440325/multiparametric-mri-ultrasound-fusion-guided-biopsy-decreases-detection-of-indolent-cancer-in-african-american-men
#11
M Kongnyuy, M M Siddiqui, A K George, A Muthigi, A Sidana, M Maruf, B Turkbey, P L Choyke, B J Wood, P A Pinto
BACKGROUND: Analysis of systematic 12-core biopsies (SBx) has shown that African-American (AA) men tend to harbor higher risk prostate cancer (PCa) at presentation relative to other races. Multiparametric magnetic resonance imaging (mpMRI) and MRI-ultrasound fusion-guided biopsy (FBx) have been shown to diagnose more intermediate- and high-risk PCa in the general population; however, the efficacy in AA remains largely uncharacterized. We aim to evaluate the utility of FBx in an AA patient cohort...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28431275/learning-non-rigid-deformations-for-robust-constrained-point-based-registration-in-image-guided-mr-trus-prostate-intervention
#12
John A Onofrey, Lawrence H Staib, Saradwata Sarkar, Rajesh Venkataraman, Cayce B Nawaf, Preston C Sprenkle, Xenophon Papademetris
Accurate and robust non-rigid registration of pre-procedure magnetic resonance (MR) imaging to intra-procedure trans-rectal ultrasound (TRUS) is critical for image-guided biopsies of prostate cancer. Prostate cancer is one of the most prevalent forms of cancer and the second leading cause of cancer-related death in men in the United States. TRUS-guided biopsy is the current clinical standard for prostate cancer diagnosis and assessment. State-of-the-art, clinical MR-TRUS image fusion relies upon semi-automated segmentations of the prostate in both the MR and the TRUS images to perform non-rigid surface-based registration of the gland...
April 12, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28400169/combined-clinical-parameters-and-multiparametric-magnetic-resonance-imaging-for-advanced-risk-modeling-of-prostate-cancer-patient-tailored-risk-stratification-can-reduce-unnecessary-biopsies
#13
Jan Philipp Radtke, Manuel Wiesenfarth, Claudia Kesch, Martin T Freitag, Celine D Alt, Kamil Celik, Florian Distler, Wilfried Roth, Kathrin Wieczorek, Christian Stock, Stefan Duensing, Matthias C Roethke, Dogu Teber, Heinz-Peter Schlemmer, Markus Hohenfellner, David Bonekamp, Boris A Hadaschik
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) is gaining widespread acceptance in prostate cancer (PC) diagnosis and improves significant PC (sPC; Gleason score≥3+4) detection. Decision making based on European Randomised Study of Screening for PC (ERSPC) risk-calculator (RC) parameters may overcome prostate-specific antigen (PSA) limitations. OBJECTIVE: We added pre-biopsy mpMRI to ERSPC-RC parameters and developed risk models (RMs) to predict individual sPC risk for biopsy-naïve men and men after previous biopsy...
April 8, 2017: European Urology
https://www.readbyqxmd.com/read/28396920/the-role-of-whole-lesion-apparent-diffusion-coefficient-analysis-for-predicting-outcomes-of-prostate-cancer-patients-on-active-surveillance
#14
Tsutomu Tamada, Hasan Dani, Samir S Taneja, Andrew B Rosenkrantz
PURPOSE: To explore the role of whole-lesion apparent diffusion coefficient (ADC) analysis for predicting outcomes in prostate cancer patients on active surveillance. METHODS: This study included 72 prostate cancer patients who underwent MRI-ultrasound fusion-targeted biopsy at the initiation of active surveillance, had a visible MRI lesion in the region of tumor on biopsy, and underwent 3T baseline and follow-up MRI examinations separated by at least one year. Thirty of the patients also underwent an additional MRI-ultrasound fusion-targeted biopsy after the follow-up MRI...
April 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28396184/focal-laser-ablation-of-prostate-cancer-feasibility-of-mri-us-fusion-for-guidance
#15
Shyam Natarajan, Tonye A Jones, Alan M Priester, Rory Geoghegan, Patricia Lieu, Merdie Delfin, Ely Felker, Daniel J A Margolis, Anthony Sisk, Allan Pantuck, Warren Grundfest, Leonard S Marks
PURPOSE: Focal laser ablation (FLA) is a potential treatment for some men with prostate cancer (CaP). As currently practiced, FLA is performed by radiologists in a MRI unit (in-bore). We evaluated the safety and feasibility of performing FLA in a urology clinic (out-of-bore), using magnetic resonance imaging-ultrasound (MRI/US) fusion for guidance. MATERIALS AND METHODS: 11 men with intermediate risk CaP were enrolled in this prospective, IRB-approved pilot study...
April 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28391284/gleason-score-within-prostate-abnormal-areas-defined-by-multiparametric-magnetic-resonance-imaging-did-not-vary-according-to-the-pirads-score
#16
Hakim Slaoui, Yann Neuzillet, Tarek Ghoneim, Mathieu Rouanne, Abdelali Abdou, Pierre Marie Lugagne-Delpon, Antoine Scherrer, Camelia Radulescu, Christian Delancourt, Vincent Molinié, Thierry Lebret
BACKGROUND: We aim to correlate multiparametric magnetic resonance imaging (mpMRI) of the prostate reporting (Prostate Imaging Reporting and Data System [PI-RADS] version 2) with the Gleason score into both radical prostatectomy (RP) specimen and MRI fusion-targeted biopsies (FTB). METHODS: mpMRI of 74 patients who underwent an RP after FTB were retrospectively reviewed. The Gleason score distribution was compared according to the PI-RADS score using the Kruskal-Wallis test...
April 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28381220/the-prostate-cancer-detection-rates-of-ceus-targeted-versus-mri-targeted-versus-systematic-trus-guided-biopsies-in-biopsy-na%C3%A3-ve-men-a-prospective-comparative-clinical-trial-using-the-same-patients
#17
A W Postema, M J V Scheltema, C K Mannaerts, R J G Van Sloun, T Idzenga, M Mischi, M R E Engelbrecht, J J M C H De la Rosette, H Wijkstra
BACKGROUND: The current standard for Prostate Cancer (PCa) detection in biopsy-naïve men consists of 10-12 systematic biopsies under ultrasound guidance. This approach leads to underdiagnosis and undergrading of significant PCa while insignificant PCa may be overdiagnosed. The recent developments in MRI and Contrast Enhanced Ultrasound (CEUS) imaging have sparked an increasing interest in PCa imaging with the ultimate goal of replacing these "blind" systematic biopsies with reliable imaging-based targeted biopsies...
April 5, 2017: BMC Urology
https://www.readbyqxmd.com/read/28373135/the-value-of-psa-density-in-combination-with-pi-rads-for-the-accuracy-of-prostate-cancer-prediction
#18
Florian A Distler, Jan P Radtke, David Bonekamp, Claudia Kesch, Heinz-Peter Schlemmer, Kathrin Wieczorek, Marietta Kirchner, Sascha Pahernik, Markus Hohenfellner, Boris A Hadaschik
PURPOSE: Multiparametric MRI (mpMRI) has an emerging role in prostate cancer (PC) diagnostics. In addition, clinical information are reliable predictors for significant PC (sPC). We analyzed if the negative predictive value (NPV) of mpMRI to rule out sPC could be improved by using clinical factors, especially prostate specific antigen (PSA)-density. METHODS: 1040 consecutive men with suspicion of PC underwent mpMRI first, followed by transperineal systematic and MRI/TRUS-fusion-guided biopsy...
March 31, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28373133/prospective-evaluation-of-prostate-imaging-reporting-and-data-system-version-2-using-the-international-society-of-urological-pathology-prostate-cancer-grade-group-system
#19
Sherif Mehralivand, Sandra Bednarova, Joanna H Shih, Francesca V Mertan, Sonia Gaur, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
PURPOSE: The Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) scoring system, introduced in 2015, is based on expert consensus. In the same time; frame, a new pathologic scoring system for prostate cancer was introduced by the International Society of Urological Pathology (ISUP). Our goal was to prospectively evaluate the cancer detection rates for each PI-RADSv2 category and compare to ISUP group scores in patients undergoing systematic biopsy and MRI/transrectal ultrasound fusion-guided biopsy...
March 31, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28346914/top-prospective-evaluation-of-a-volume-based-computer-assisted-method-for-transperineal-optimized-prostate-biopsy
#20
Claudia Kesch, Jan Philipp Radtke, Ionel Valentin Popeneciu, Claudia Gasch, Svenja C Dieffenbacher, Tilman Klein, Heinz-Peter Schlemmer, Kathrin Wieczorek, Pawel Zogal, Markus Hohenfellner, Georgios Sakas, Boris Alexander Hadaschik
OBJECTIVE: This study is a prospective evaluation of a volume-based, computer-assisted method for transperineal optimized prostate (TOP) biopsy. The TOP algorithm automates core planning for systematic prostate biopsies using the 3-dimensional organ contour and an alterable volume for tumors to be excluded. SUBJECTS AND METHODS: MRI-transrectal ultrasound fusion biopsy with MRI-targeted biopsies (TBs) and systematic-TOP biopsies were performed on 172 men between October 2013 and March 2014...
March 28, 2017: Urologia Internationalis
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