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Fusion biopsy prostate

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https://www.readbyqxmd.com/read/29339663/evaluation-of-magnetic-resonance-imaging-ultrasound-fusion-biopsy-in-patients-with-low-risk-prostate-cancer-under-active-surveillance-undergoing-surveillance-biopsy
#1
Angelika Borkowetz, Theresa Renner, Ivan Platzek, Marieta Toma, Roman Herout, Martin Baunacke, Christer Groeben, Johannes Huber, Michael Laniado, Gustavo B Baretton, Michael Froehner, Stefan Zastrow, Manfred P Wirth
INTRODUCTION: Targeted biopsy of tumour-suspicious lesions detected in multiparametric magnetic resonance imaging (mpMRI) plays an increasing role in the active surveillance (AS) of patients with low-risk prostate cancer (PCa). The aim of this study was to compare MRI/ultrasound-fusion biopsy (fusPbx) with systematic biopsy (sysPbx) in patients undergoing biopsy for AS. METHODS: Patients undergoing mpMRI and transperineal fusPbx combined with transrectal sysPbx (comPbx) as surveillance biopsy were investigated...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29318440/correction-to-mri-us-fusion-guided-biopsy-performing-exclusively-targeted-biopsies-for-the-early-detection-of-prostate-cancer
#2
Maurizio Del Monte, Costantino Leonardo, Vincenzo Salvo, Marcello Domenico Grompone, Martina Pecoraro, Arnaldo Stanzione, Riccardo Campa, Francesco Vullo, Alessandro Sciarra, Carlo Catalano, Valeria Panebianco
In the original publication of the article, the first and last names of the second author were interchanged.
January 9, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29282497/internal-fusion-exact-correlation-of-transrectal-ultrasound-images-of-the-prostate-by-detailed-landmarks-over-time-for-targeted-biopsies-or-follow-up
#3
REVIEW
Yanqi Xie, Theodoros Tokas, Björn Grabski, Tillmann Loch
PURPOSE: Innovative imaging modalities are applied for diagnosing and follow-up of prostate cancer (PCa). To perform authentic targeted biopsies and evaluate prostate changes, it is essential to reliably identify and hit targets in their true anatomical location over time. A newly described image correlation method (Internal Fusion) allows precise correlation of serial transrectal ultrasound (TRUS) images in vitro and vivo. Identifiable morphologic structures such as prostatic calcifications define internal anchor points (Internal Landmarks) to facilitate exact correlation...
December 27, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29277318/t2e-tmprss2-erg-fusion-transcripts-are-associated-with-higher-levels-of-amacr-mrna-and-a-subsequent-prostate-cancer-diagnosis-in-patients-with-atypical-small-acinar-proliferation
#4
Isil Ezgi Eryilmaz, Yakup Kordan, Berna Aytac Vuruskan, Onur Kaygısız, Berrin Tunca, Gulsah Cecener
Genetic rearrangements involving androgen-regulated transmembrane protease serine 2 (TMPRSS2) and genes from the ETS transcription factor family, most commonly ERG and ETV1, result in alteration that responsible for oncogenic activity in prostate cancer (PC). The aims of the present study were to: 1) investigate the frequency of these fusion transcripts in prostate tissue samples obtained from patients diagnosed with atypical small acinar proliferation (ASAP), 2) determine any clinical significance of T2E expression at the RNA level in predicting PC detection in subsequent biopsies, and 3) evaluate expression of the PC marker, alpha-methylacyl-CoA racemase (AMACR), according to T2E status by real-time quantitative reverse transcription PCR (RT-qPCR)...
December 22, 2017: Gene
https://www.readbyqxmd.com/read/29261439/targeting-androgen-receptor-and-dna-repair-in-metastatic-castration-resistant-prostate-cancer-results-from-nci-9012
#5
Maha Hussain, Stephanie Daignault-Newton, Przemyslaw W Twardowski, Costantine Albany, Mark N Stein, Lakshmi P Kunju, Javed Siddiqui, Yi-Mi Wu, Dan Robinson, Robert J Lonigro, Xuhong Cao, Scott A Tomlins, Rohit Mehra, Kathleen A Cooney, Bruce Montgomery, Emmanuel S Antonarakis, Daniel H Shevrin, Paul G Corn, Young E Whang, David C Smith, Megan V Caram, Karen E Knudsen, Walter M Stadler, Felix Y Feng, Arul M Chinnaiyan
Purpose To determine whether cotargeting poly (ADP-ribose) polymerase-1 plus androgen receptor is superior to androgen receptor inhibition in metastatic castration-resistant prostate cancer (mCRPC) and whether ETS fusions predict response. Patients and Methods Patients underwent metastatic site biopsy and were stratified by ETS status and randomly assigned to abiraterone plus prednisone without (arm A) or with veliparib (arm B). Primary objectives were: confirmed prostate-specific antigen (PSA) response rate (RR) and whether ETS fusions predicted response...
December 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29233150/a-prospective-study-of-magnetic-resonance-imaging-and-ultrasonography-mri-us-fusion-targeted-biopsy-and-concurrent-systematic-transperineal-biopsy-with-the-average-of-18-cores-to-detect-clinically-significant-prostate-cancer
#6
Yuji Hakozaki, Hisashi Matsushima, Jimpei Kumagai, Taro Murata, Tomoko Masuda, Yoko Hirai, Mai Oda, Nobuo Kawauchi, Munehiro Yokoyama, Yukio Homma
BACKGROUND: This study compared the detection rates for clinically significant prostate cancer (CSPC) between magnetic resonance imaging and ultrasonography (MRI/US)-fusion-targeted biopsy (TB), systematic biopsy (SB) and combination of TB and SB. METHODS: This prospective study evaluated simultaneous TB and SB for consecutive patients with suspicious lesions that were detected using pre-biopsy multiparametric MRI. A commercially available real-time virtual sonography system was used to perform the MRI/US-fusion TB with the transperineal technique...
December 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/29232269/mr-guided-biopsy-and-focal-therapy-new-options-for-prostate-cancer-management
#7
Fuad F Elkhoury, Demetrios N Simopoulos, Leonard S Marks
PURPOSE OF REVIEW: Options for prostate cancer management are rapidly expanding. The recent advent of MRI technology has led to guided prostate biopsies by radiologists working in-bore or by urologists using MR/US fusion technology. The resulting tumor visualization now provides the option of focal therapy. Currently available are highly directed energies - focused ultrasound (HIFU), cryotherapy, and laser - all offering the hope of curing prostate cancer with few side effects. RECENT FINDINGS: MRI now enables visualization of many prostate cancers...
December 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29226826/prostate-magnetic-resonance-imaging-interpretation-varies-substantially-across-radiologists
#8
Geoffrey A Sonn, Richard E Fan, Pejman Ghanouni, Nancy N Wang, James D Brooks, Andreas M Loening, Bruce L Daniel, Katherine J To'o, Alan E Thong, John T Leppert
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists of varying expertise has not been verified. OBJECTIVE: To assess variability in mpMRI reporting and diagnostic accuracy across radiologists of varying experience in routine clinical care. DESIGN, SETTING, AND PARTICIPANTS: Men who underwent mpMRI and MR-fusion biopsy between 2014-2016...
December 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29211932/targeted-versus-systematic-robot-assisted-transperineal-mri-trus-fusion-prostate-biopsy
#9
J Mischinger, S Kaufmann, G I Russo, N Harland, S Rausch, B Amend, M Scharpf, L Loewe, T Todenhoefer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
OBJECTIVES: To evaluate the performance of transperineal robot-assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. PATIENTS AND METHODS: Patients were admitted to RA biopsy between 2014-2016. Prior to RA-TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA-TB planning. In addition, RA-SB was performed...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29205162/multiparametric-mri-guided-biopsy-in-the-era-of-precision-medicine
#10
Miguel A Bergero, Pablo F Martínez, Jan P Radtke, Boris A Hadaschik
OBJECTIVE: Technical improvements in prostate magnetic resonance imaging (MRI) have resulted in the use of MRI to target prostate biopsy. This allowed urologists to progress from blind biopsies to target biopsies with a better performance in prostate cancer (PC) diagnosis. We herein review the current status of Magnetic Resonance Imaging Guided Biopsy (MRGB) for the detection of PC. METHODS: A systematic review of the literature was conducted using PubMed, Embase and Cochrane using the search criteria: "PC and MRI/US fusion" or "PC and guided biopsy" or "PC and multiparametric MRI" or "PC and MRI guided prostate biopsy"...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29203158/are-concurrent-systematic-cores-needed-at-the-time-of-targeted-biopsy-in-patients-with-prior-negative-prostate-biopsies
#11
S Albisinni, F Aoun, A Noel, E El Rassy, M Lemort, M Paesmans, R van Velthoven, T Roumeguère, A Peltier
INTRODUCTION AND OBJECTIVES: MRI-guided targeted biopsies are advised in patients who have undergone an initial series of negative systematic biopsies, in whom prostate cancer (PCa) suspicion remains elevated. The aim of the study was to evaluate whether, in men with prior negative prostate biopsies, systematic cores are also warranted at the time of an MRI-targeted repeat biopsy. MATERIAL AND METHODS: We enrolled patients with prior negative biopsy undergoing real time MRI/TRUS fusion guided prostate biopsy at our institute between 2014 and 2016...
December 1, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29198006/characteristics-of-pi-rads-4-lesions-within-the-prostatic-peripheral-zone-a-retrospective-diagnostic-accuracy-study-evaluating-170-lesions
#12
Prasad R Shankar, Nicole E Curci, Matthew S Davenport
PURPOSE: To determine whether peripheral zone PI-RADS 4 observations can be further risk-stratified. METHODS: This was an IRB-approved HIPAA-compliant retrospective diagnostic accuracy study. Peripheral zone PI-RADS 4 observations prospectively identified at the study institution from 8/1/2015 to 12/31/2016 (n = 170 in 149 mpMRIs) were reviewed independently by two blinded genitourinary radiologists on the basis of (a) PI-RADS v2 shape, (b) pattern of peripheral zone sparing, and (c) rationale for PI-RADS 4 designation...
December 2, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29197919/prostate-ultrasound-back-in-business
#13
REVIEW
Nicolae Crisan, Iulia Andras, Corina Radu, David Andras, Radu-Tudor Coman, Paul Tucan, Doina Pisla, Dana Crisan, Ioan Coman
The use of grey scale prostate ultrasound decreased after the implementation of magnetic resonance imaging (MRI) for the diagnosis and evaluation of prostate cancer. The new developments, such as multiparametric ultrasound and MRI-ultrasound fusion technology, renewed the interest for this imaging method in the assessment of prostate cancer. The purpose of this paper was to review the current role of prostate ultrasound in the setting of these new applications. A thorough reevaluation of the selection criteria of the patients is required to assess which patients would benefit from multiparametric ultrasound, who wouldbenefit from multiparametric MRI or the combination of both to assist prostate biopsy in order to ensure the balance between overdiagnosis and underdiagnosis of prostate cancer...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29188489/does-the-prostate-imaging-reporting-and-data-system-pi-rads-version-2-improve-accuracy-in-reporting-anterior-lesions-on-multiparametric-magnetic-resonance-imaging-mpmri
#14
Richard Hoffmann, Callum Logan, Michael O'Callaghan, Kirsten Gormly, Ken Chan, Darren Foreman
INTRODUCTION: Multiparametric MRI (mpMRI) is useful in detecting anterior prostate tumours. Due to the location of anterior tumours, they are often diagnosed with a large size and may be suspicious for extra-prostatic extension (EPE). We aim to evaluate whether PI-RADS v2 is more accurate in assessing anterior prostate lesions identified on mpMRI compared to PI-RADS v1. METHODS: Patients with anterior prostate lesions diagnosed on mpMRI who proceeded to a cognitive fusion transperineal prostate biopsy were identified...
November 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29187467/diagnostic-performance-of-multiparametric-magnetic-resonance-imaging-and-fusion-targeted-biopsy-to-detect-significant-prostate-cancer
#15
Manuela A Hoffmann, Kasra Taymoorian, Christian Ruf, Arnd Gerhards, Karlheinz Leyendecker, Thomas Stein, Frank M Jakobs, Mathias Schreckenberger
BACKGROUND/AIM: Multiparametric magnetic resonance imaging combined with ultrasound-fusion-targeted biopsy of the prostate intends to increase diagnostic precision, which has to be clarified. PATIENTS AND METHODS: We performed multiparametric magnetic resonance imaging followed by ultrasound-fusion-guided perineal biopsy in 99 male patients with elevated prostate-specific-antigen and previous negative standard biopsy-procedures. RESULTS: In 33/99 patients (33%) no malignancy could be confirmed by histopathology...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29173269/transrectal-ultrasound-guided-prostate-biopsies-vs-mri-ultrasound-fusion-targeted-biopsies-who-are-the-best-candidates
#16
Elsa Bey, Olivier Gaget, Jean-Luc Descotes, Quentin Franquet, Jean-Jacques Rambeaud, Jean-Alexandre Long, Gaelle Fiard
INTRODUCTION: The aim of this study was to compare the results of ultrasound-guided prostate biopsies (US-PB) and magnetic resonance imaging ultrasound fusion biopsies (MRI-PB) in two contemporary cohorts, and to describe the parameters orienting the choice of technique. METHODS: Two contemporary cohorts of patients undergoing US-PB or MR-PB using the Urostation® (Koelis, Grenoble, France) between November 2010 and July 2015 were analyzed retrospectively. Patients with metastatic cancer or recurrence after treatment, saturation biopsies, and US-PB performed after a negative MRI were excluded...
December 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29168004/diffusion-weighted-imaging-of-the-prostate-should-we-use-quantitative-metrics-to-better-characterize-focal-lesions-originating-in-the-peripheral-zone
#17
Thibaut Pierre, Francois Cornud, Loïc Colléter, Frédéric Beuvon, Frantz Foissac, Nicolas B Delongchamps, Paul Legmann
PURPOSE: To compare inter-reader concordance and accuracy of qualitative diffusion-weighted (DW) PIRADSv2.0 score with those of quantitative DW-MRI for the diagnosis of peripheral zone prostate cancer. MATERIALS AND METHODS: Two radiologists independently assigned a DW-MRI-PIRADS score to 92 PZ-foci, in 74 patients (64.3±5.6 years old; median PSA level: 8 ng/ml, normal DRE in 70 men). A standardised ADCmean and nine ADC-derived parameters were measured, including ADCratios with the whole-prostate (WP-ADCratio) or the mirror-PZ (mirror-ADCratio) as reference areas...
November 22, 2017: European Radiology
https://www.readbyqxmd.com/read/29164056/prostate-cancer-imaging-and-biomarkers-guiding-safe-selection-of-active-surveillance
#18
REVIEW
Zachary A Glaser, Jennifer B Gordetsky, Kristin K Porter, Sooryanarayana Varambally, Soroush Rais-Bahrami
Background: Active surveillance (AS) is a widely adopted strategy to monitor men with low-risk, localized prostate cancer (PCa). Current AS inclusion criteria may misclassify as many as one in four patients. The advent of multiparametric magnetic resonance imaging (mpMRI) and novel PCa biomarkers may offer improved risk stratification. We performed a review of recently published literature to characterize emerging evidence in support of these novel modalities. Methods: An English literature search was conducted on PubMed for available original investigations on localized PCa, AS, imaging, and biomarkers published within the past 3 years...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29155186/prediction-of-prostate-cancer-risk-among-men-undergoing-combined-mri-targeted-and-systematic-biopsy-using-novel-pre-biopsy-nomograms-that-incorporate-mri-findings
#19
Marc A Bjurlin, Andrew B Rosenkrantz, Saradwata Sarkar, Herbert Lepor, William C Huang, Richard Huang, Rajesh Venkataraman, Samir S Taneja
OBJECTIVE: To develop nomograms that predict the probability of overall PCa and clinically significant PCa (Gleason ≥7) on MRI targeted, and combined MRI-targeted and systematic, prostate biopsy. MATERIALS AND METHODS: From June 2012 to August 2014, MR-US fusion targeted prostate biopsy was performed on 464 men with suspicious regions identified on pre-biopsy 3T MRI along with systematic 12 core biopsy. Logistic regression modeling was used to evaluate predictors of overall and clinically significant PCa, and corresponding nomograms were generated for men who were not previously biopsied or had one or more prior negative biopsies...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29154904/risk-of-upgrading-from-prostate-biopsy-to-radical-prostatectomy-pathology-does-saturation-biopsy-of-index-lesion-during-mpmri-trus-fusion-biopsy-help
#20
Brian P Calio, Abhinav Sidana, Dordaneh Sugano, Sonia Gaur, Mahir Maruf, Amit L Jain, Maria J Merino, Peter L Choyke, Bradford J Wood, Peter A Pinto, Baris Turkbey
PURPOSE: To determine if 'saturation' of the index-lesion during MRI-TRUS fusion-guided (fusion) biopsy decreases rate of pathological upgrade from biopsy to radical-prostatectomy (RP). MATERIALS/METHODS: A prospectively maintained single institution database was analyzed for patients who underwent both fusion and systematic biopsy followed by RP (2010-16). Index-lesion was defined as lesion with largest diameter on T2W-MRI. Patients with saturation of the index-lesion (SIL) had transrectal fusion biopsy targets obtained at 6mm intervals along the long axis of index-lesion; patients with nonsaturation of the index-lesion (NSIL) had only one target obtained from the lesion...
November 15, 2017: Journal of Urology
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