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Fusion biopsy prostate

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https://www.readbyqxmd.com/read/29127096/retention-of-interstitial-genes-between-tmprss2-and-erg-is-associated-with-low-risk-prostate-cancer
#1
Stephen J Murphy, Farhad Kosari, R Jeffrey Karnes, Aqsa Nasir, Sarah H Johnson, Athanasios G Gaitatzes, James B Smadbeck, Laureano J Rangel, George Vasmatzis, John C Cheville
TMPRSS2-ERG gene fusions occur in over 50% of prostate cancers, but their impact on clinical outcomes is not well understood. Retention of interstitial genes between TMPRSS2 and ERG has been reported to influence tumor progression in an animal model. In this study, we analyzed the status of TMPRSS2-ERG fusion genes and interstitial genes in tumors from a large cohort of men treated surgically for prostate cancer, associating alterations with biochemical progression. Through whole-genome mate pair sequencing, we mapped and classified rearrangements driving ETS family gene fusions in 133 cases of very low-, low-, intermediate-, and high-risk prostate cancer from radical prostatectomy specimens...
November 10, 2017: Cancer Research
https://www.readbyqxmd.com/read/29126575/validation-of-prostate-imaging-reporting-and-data-system-version-2-a-retrospective-analysis
#2
Michael Nguyentat, Alexander Ushinsky, Alessandra Miranda-Aguirre, Edward Uchio, Chandana Lall, Layla Shirkhoda, Thomas Lee, Christopher Green, Roozbeh Houshyar
PURPOSE: Use of magnetic resonance imaging (MRI)/transrectal ultrasound fusion biopsies to determine the accuracy of multiparametric MRI (mpMRI), using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2), for detecting clinically significant prostate cancer in the overall gland and specifically the peripheral zone (PZ) and transitional zone (TZ). METHODS: A retrospective analysis of patients who underwent fusion biopsy identified 137 men with 231 prostate lesions was approved by the Institutional Review Board...
October 12, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29112469/risk-of-clinically-significant-prostate-cancer-associated-with-prostate-imaging-reporting-and-data-system-category-3-equivocal-lesions-identified-on-multiparametric-prostate-mri
#3
Alison D Sheridan, Sameer K Nath, Jamil S Syed, Sanjay Aneja, Preston C Sprenkle, Jeffrey C Weinreb, Michael Spektor
OBJECTIVE: The objective of this study is to determine the frequency of clinically significant cancer (CSC) in Prostate Imaging Reporting and Data System (PI-RADS) category 3 (equivocal) lesions prospectively identified on multiparametric prostate MRI and to identify risk factors (RFs) for CSC that may aid in decision making. MATERIALS AND METHODS: Between January 2015 and July 2016, a total of 977 consecutively seen men underwent multiparametric prostate MRI, and 342 underwent MRI-ultrasound (US) fusion targeted biopsy...
November 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29094042/evaluation-of-mri-ultrasound-fusion-guided-prostate-biopsy-using-transrectal-and-transperineal-approaches
#4
Susanne Tewes, Inga Peters, Ansgar Tiemeyer, Matti Peperhove, Dagmar Hartung, Stefanie Pertschy, Markus A Kuczyk, Frank Wacker, Katja Hueper
Purpose: To evaluate transrectal (TR) and transperineal (TP) approaches for MRI/ultrasound (MRI/US) fusion-guided biopsy to detect prostate cancer (PCa). Materials and Methods: 154 men underwent multiparametric MRI and MRI/US fusion-guided biopsy between July 2012 and October 2016. 79/154 patients were biopsied with a TR approach and 75/154 with a TP approach. MRI was retrospectively analyzed according to PI-RADS version 2. PI-RADS scores were compared with histopathological results...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29084410/significance-of-mri-transrectal-ultrasound-fusion-three-dimensional-model-guided-targeted-biopsy-based-on-transrectal-ultrasound-guided-systematic-biopsy-in-prostate-cancer-detection-a-systematic-review-and-meta-analysis
#5
Yongquan Tang, Zhihong Liu, Liangyou Tang, Ruochen Zhang, Yiping Lu, Jiayu Liang, Zijun Zou, Chuan Zhou, Yujie Wang
PURPOSE: To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). METHODS: Pubmed and Web of science were searched. Studies with men having a suspicious lesion on MRI were included, which were divided into initial biopsy, previous negative biopsy, and mixed groups in meta-analysis. RESULTS: Totally 13 cohorts in 12 studies, with 3,225 men were included...
October 30, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29083999/multiparametric-mri-fusion-guided-biopsy-for-the-diagnosis-of-prostate-cancer
#6
Claudia Kesch, Viktoria Schütz, Svenja Dieffenbacher, David Bonekamp, Boris Alexander Hadaschik, Markus Hohenfellner, Jan P Radtke
PURPOSE OF REVIEW: To discuss the timing, benefits, limitations and current controversies of multiparametric magnet resonance imaging (mpMRI) combined with fusion-guided biopsy and consider how additional incorporation of multivariable risk stratification might further improve prostate cancer diagnosis. RECENT FINDINGS: MpMRI has been proven advantageous over standard practice for biopsy-naïve men and men with previous biopsy in large prospective studies providing level 1b evidence...
October 27, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29075977/mri-us-fusion-guided-biopsy-performing-exclusively-targeted-biopsies-for-the-early-detection-of-prostate-cancer
#7
Maurizio Del Monte, Leonardo Costantino, Vincenzo Salvo, Marcello Domenico Grompone, Martina Pecoraro, Arnaldo Stanzione, Riccardo Campa, Francesco Vullo, Alessandro Sciarra, Carlo Catalano, Valeria Panebianco
PURPOSE: The aim of this study was to validate the role of MR/Ultrasound Fusion-Guided Targeted Biopsy as a first diagnostic modality in subjects with clinical suspicion of prostate cancer (PCa). MATERIALS AND METHODS: 108 men (age range 46-78 years) with clinical suspicion for PCa (PSA > 4 ng/mL) underwent multiparametric MRI of the prostate (mpMRI) and, when suspicious lesion were found (according to the PIRADSv2 scoring system), targeted biopsy was performed...
October 26, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29074136/new-approach-to-guide-target-prostate-biopsy-technique-and-initial-experience
#8
Enrique Gómez Gómez, José Valero Rosa, Julia Carrasco Valiente, Francisco Triviño Tarradas, Francisco Anglada Curado, Daniel López Ruiz, María José Requena Tapia
OBJECTIVE: To describe the technique of transrectal biopsy with a new device that fuses multiparametric magnetic resonance (mpMRI) and ultrasound images in real time to guide target biopsies and to evaluate our initial experience. METHODS: Patients with persistent suspicion of prostate cancer despite a previous negative biopsy and who had an mpMRI before the biopsy were selected. All patients underwent target biopsy plus standard systematic biopsy. Significant prostate cancer (sig PCa) was defined according to the Epstein criteria for standard biopsy and Gleason grade of >7 and a positive core length of >5 mm for target biopsy...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/29064653/prostate-cancer-recurrence-in-vas-deferens-fusion-image-guide-as-an-important-tool-in-dignosis
#9
Leonardo Guedes Moreira Valle, Antônio Rahal, Priscila Mina Falsarella, Juliano Ribeiro de Andrade, Oren Smaletz, Akemi Osawa, Rodrigo Gobbo Garcia
The biochemical recurrence after local treatment for prostate cancer is an often challenging condition of clinical management. The aim of this report is to demonstrate the importance of the association of various imaging methods in the identification and subsequent accurate percutaneous biopsy in patients with recurrence of prostate cancer, especially in unusual sites. An 86 years old male with biochemical recurrence, during radiological investigation a PET-MRI was noted the presence of an asymmetry of the vas deferens with PSMA- 68Ga uptaken, suggesting the recurrence...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29046984/spatial-tracking-of-targeted-prostate-biopsy-locations-moving-towards-effective-focal-partial-prostate-gland-ablation-with-improved-treatment-planning
#10
REVIEW
Steven Sidelsky, Shaan Setia, Srinivas Vourganti
The ability to selectively characterize, localize, and predict the specific areas of the prostate gland which harbor the worst biologic behavior is requisite for optimal prostate cancer therapy, especially in the emerging field of partial prostate gland ablation (focal therapy). In this manuscript, we highlight contemporary techniques in target tracking for focal therapy planning. Multiparametric magnetic resonance imaging has emerged as a dominant strategy to localize biopsy sites most likely to contain high-grade lesions...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29045233/the-current-state-of-mr-imaging-targeted-biopsy-techniques-for-detection-of-prostate-cancer
#11
REVIEW
Sadhna Verma, Peter L Choyke, Steven C Eberhardt, Aytekin Oto, Clare M Tempany, Baris Turkbey, Andrew B Rosenkrantz
Systematic transrectal ultrasonography (US)-guided biopsy is the standard approach for histopathologic diagnosis of prostate cancer. However, this technique has multiple limitations because of its inability to accurately visualize and target prostate lesions. Multiparametric magnetic resonance (MR) imaging of the prostate is more reliably able to localize significant prostate cancer. Targeted prostate biopsy by using MR imaging may thus help to reduce false-negative results and improve risk assessment. Several commercial devices are now available for targeted prostate biopsy, including in-gantry MR imaging-targeted biopsy and real-time transrectal US-MR imaging fusion biopsy systems...
November 2017: Radiology
https://www.readbyqxmd.com/read/29034282/differentiation-of-prostate-cancer-lesions-in-the-transition-zone-by-diffusion-weighted-mri
#12
Jie Bao, Ximing Wang, Chunhong Hu, Jianquan Hou, Fenglin Dong, Lingchuan Guo
OBJECTIVE: To differentiate prostate cancer lesions in transition zone by diffusion-weighted-MRI (DW-MRI). METHODS: Data from a total of 63 patients who underwent preoperative DWI (b of 0-1000 s/mm(2)) were prospectively collected and processed by a monoexponential (DWI) model and compared with a biexponential (IVIM) model for quantitation of apparent diffusion coefficients (ADCs), perfusion fraction f, diffusivity D and pseudo-diffusivity D*. Histogram analyses were performed by outlining entire-tumor regions of interest (ROIs)...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29024425/multicentre-evaluation-of-magnetic-resonance-imaging-supported-transperineal-prostate-biopsy-in-biopsy-na%C3%A3-ve-men-with-suspicion-of-prostate-cancer
#13
N L Hansen, T Barrett, C Kesch, L Pepdjonovic, D Bonekamp, R O'Sullivan, F Distler, A Warren, C Samel, B Hadaschik, J Grummet, C Kastner
OBJECTIVES: To analyse the detection rates of primary MRI-fusion transperineal prostate biopsy using combined targeted and systematic core distribution in three tertiary referral centres. PATIENTS AND METHODS: Multicentre, prospective outcome study of 807 consecutive biopsy-naïve patients having undergone MRI-guided transperineal prostate biopsy as the first diagnostic intervention between 10/2012 and 05/2016. MRI was reported following PI-RADS criteria. 236 patients had 18-24 systematic transperineal biopsies only, and 571 patients underwent additional targeted biopsies either by MRI-fusion or cognitive targeting if PI-RADS ≥3 lesions were present...
October 11, 2017: BJU International
https://www.readbyqxmd.com/read/29019021/analysis-of-histological-findings-obtained-combining-us-mp-mri-fusion-guided-biopsies-with-systematic-us-biopsies-mp-mri-role-in-prostate-cancer-detection-and-false-negative
#14
Eliodoro Faiella, Domiziana Santucci, Federico Greco, Giulia Frauenfelder, Viola Giacobbe, Giovanni Muto, Bruno Beomonte Zobel, Rosario Francesco Grasso
AIMS AND OBJECTIVES: To evaluate the diagnostic accuracy of mp-MRI correlating US/mp-MRI fusion-guided biopsy with systematic random US-guided biopsy in prostate cancer diagnosis. MATERIALS AND METHODS: 137 suspected prostatic abnormalities were identified on mp-MRI (1.5T) in 96 patients and classified according to PI-RADS score v2. All target lesions underwent US/mp-MRI fusion biopsy and prostatic sampling was completed by US-guided systematic random 12-core biopsies...
October 10, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28988963/defining-novel-and-practical-metrics-to-assess-the-deliverables-of-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-prostate-biopsy
#15
Benjamin T Ristau, David Y T Chen, Jeffrey Ellis, Aseem Malhotra, Lyudmilla DeMora, Rosaleen B Parsons, Barton Milestone, Marion Brody, Rosalia Viterbo, Richard Greenberg, Marc Smaldone, Robert Uzzo, Jordan Anaokar, Alexander Kutikov
PURPOSE: Multiparametric magnetic resonance (mpMRI)/ultrasound targeted prostate biopsy (TB) is touted as a tool to improve prostate cancer care. Yet, the true clinical utility of TB over transrectal ultrasound-guided prostate biopsy (TRUS-B) has not been systematically analyzed. We introduce two metrics to better quantify and report the deliverables of TB. MATERIALS AND METHODS: We reviewed our prospective database containing patients who underwent simultaneous TB/TRUS-B...
October 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28987685/sub-differentiating-equivocal-pi-rads-3-lesions-in-multiparametric-magnetic-resonance-imaging-of-the-prostate-to-improve-cancer-detection
#16
N L Hansen, B C Koo, A Y Warren, C Kastner, T Barrett
PURPOSE: To evaluate sub-differentiation of PI-RADS-3 prostate lesions using pre-defined T2- and diffusion-weighted (DWI) MRI criteria, to aid the biopsy decision process. METHODS: 143 patients with PIRADS-3 index lesions on MRI underwent targeted transperineal-MR/US fusion biopsy. Radiologists with 2 and 7-years experience performed blinded retrospective second-reads using set criteria and assigned biopsy recommendations. Inter-reader agreement, Gleason score (GS), positive (PPV) predictive values (±95% confidence intervals) were calculated and compared by Fisher's exact test with Bonferroni-Hom correction...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28978094/dna-repair-deregulation-in-discrete-prostate-cancer-lesions-identified-on-multi-parametric-mri-and-targeted-by-mri-ultrasound-fusion-guided-biopsy
#17
Caleb R Dulaney, Soroush Rais-Bahrami, Debra Della Manna, Jennifer B Gordetsky, Jeffrey W Nix, Eddy S Yang
Prostate cancer is histologically and molecularly heterogeneous. Clinically significant disease is often driven by dominant intra-prostatic lesions (IPLs). Prostate cancers cluster into molecular phenotypes with substantial genetic heterogeneity making pathway-based molecular analysis appealing. MRI/ultrasound fusion biopsy provides a unique opportunity to characterize tumor biology of discrete lesions at diagnosis. This study determined the feasibility of pathway-based gene expression analysis of prostate biopsies and characterized cancer pathway deregulation...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976544/multi-institutional-nomogram-predicting-benign-prostate-pathology-on-magnetic-resonance-ultrasound-fusion-biopsy-in-men-with-a-prior-negative-12-core-systematic-biopsy
#18
Matthew Truong, Bokai Wang, Jennifer B Gordetsky, Jeffrey W Nix, Thomas P Frye, Edward M Messing, John V Thomas, Changyong Feng, Soroush Rais-Bahrami
BACKGROUND: Prostate multiparametric magnetic resonance imaging (mpMRI) may be recommended for patients with a prior negative systematic biopsy (SB). However, a proportion of these patients will continue to have no prostate cancer (PCa) identified on magnetic resonance/ultrasound fusion biopsy (FB) despite abnormal mpMRI findings. METHODS: In this multi-institutional, retrospective study, clinical and mpMRI parameters were assessed for 285 consecutive patients with at least 1 prior negative biopsy who underwent FB for a Prostate Imaging Reporting and Data System (PI-RADS) score of 3 to 5 at the University of Rochester Medical Center from December 2014 to December 2016, or at the University of Alabama at Birmingham from February 2014 to February 2017...
October 4, 2017: Cancer
https://www.readbyqxmd.com/read/28971090/molecular-imaging-and-fusion-targeted-biopsy-of-the-prostate
#19
Baowei Fei, Peter T Nieh, Viraj A Master, Yun Zhang, Adeboye O Osunkoya, David M Schuster
PURPOSE: This paper provides a review on molecular imaging with positron emission tomography (PET) and magnetic resonance imaging (MRI) for prostate cancer detection and its applications in fusion targeted biopsy of the prostate. METHODS: Literature search was performed through the PubMed database using the keywords "prostate cancer", "MRI/ultrasound fusion", "molecular imaging", and "targeted biopsy". Estimates in autopsy studies indicate that 50% of men older than 50 years of age have prostate cancer...
February 2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28969413/the-eternal-enigma-in-prostatic-biopsy-access-route
#20
Andrea Fabiani, Emanuele Principi, Alessandra Filosa, Lucilla Servi
Dear Editors,We read with interest the article by Di Franco and co-workers (1). The introduction of prostatic magnetic resonance and the relative fusion-biopsy have not yet allowed the expected improvements in prostate biopsy. To our knowledge, there are no works that demonstrate the superiority of fusion techniques on the remaining ultrasound guided prostate biopsies that are still the widely used in the diagnosis of prostate cancer. Furthemore, these technologies are expensive exams and they are not yet available in all centers, especially in those minors...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
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