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Fusion biopsy prostate

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https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#1
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27882057/robotic-assisted-laparoscopic-prostatectomy-performed-after-previous-suprapubic-prostatectomy
#2
Johnson F Tsui, Michael Feuerstein, Seyed Behzad Jazayeri, David B Samadi
Operative management of prostate cancer in a patient who has undergone previous open suprapubic simple prostatectomy poses a unique surgical challenge. Herein, we describe a case of intermediate risk prostate cancer in a man who had undergone simple prostatectomy ten years prior to presentation. The patient was found to have Gleason 7 prostate cancer on MRI fusion biopsy of the prostate for elevated PSA and underwent an uncomplicated robot assisted laparoscopic radical prostatectomy.
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27871829/the-role-of-ipsilateral-and-contralateral-trus-guided-systematic-prostate-biopsy-in-men-with-unilateral-mri-lesion-undergoing-mri-us-fusion-targeted-prostate-biopsy
#3
Darren J Bryk, Elton Llukani, Samir S Taneja, Andrew B Rosenkrantz, William C Huang, Herbert Lepor
OBJECTIVE: To determine how ipsilateral (ipsi) and contralateral (contra) systematic biopsies (SB) impacts detection of clinically significant versus insignificant prostate cancer (PCa) in men with unilateral MRI lesion undergoing MRI fusion target biopsy (MRF-TB). MATERIALS AND METHODS: 211 cases with one unilateral MRI lesion were subjected to SB and MRF-TB. Biopsy tissue cores from the MRF-TB, ipsi-SB and contra-SB were analyzed separately. RESULTS: A direct relationship was observed between MRI suspicious score (SS) and detection of any cancer, Gleason 6 PCa and Gleason > 6 PCa...
November 18, 2016: Urology
https://www.readbyqxmd.com/read/27865106/high-speed-biosensing-strategy-for-non-invasive-profiling-of-multiple-cancer-fusion-genes-in-urine
#4
Kevin M Koo, Eugene J H Wee, Matt Trau
Aberrant chromosal rearrangements, such as the multiple variants of TMPRSS2:ERG fusion gene mutations in prostate cancer (PCa), are promising diagnostic and prognostic biomarkers due to their specific expression in cancerous tissue only. Additionally, TMPRSS2:ERG variants are detectable in urine to provide non-invasive PCa diagnostic sampling as an attractive surrogate for needle biopsies. Therefore, rapid and simplistic assays for identifying multiple urinary TMPRSS2:ERG variants are potentially useful to aid in early cancer detection, immediate patient risk stratification, and prompt personalized treatment...
November 12, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27864107/should-hypoechoic-lesions-on-trus-be-sampled-during-mri-targeted-prostate-biopsy
#5
Nabeel A Shakir, M Minhaj Siddiqui, Arvin K George, Michael Kongnyuy, Richard Ho, Michele Fascelli, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
OBJECTIVES: To determine whether supplemental biopsy of hypoechoic ultrasound lesions (HUL) incidentally found during MRI-transrectal ultrasound (TRUS) fusion-targeted prostate biopsy results in improved prostate cancer (PCa) detection. METHODS: Patients underwent MRI-TRUS targeted biopsy as part of an ongoing prospective trial from August 2007 to February 2015. For men with HUL, the biopsy pathology of HUL and MRI lesions was classified according to the updated 2014 International Society of Urological Pathology (ISUP) grading system...
November 15, 2016: Urology
https://www.readbyqxmd.com/read/27862869/multicentre-evaluation-of-target-and-systematic-biopsies-using-magnetic-resonance-and-ultrasound-image-fusion-guided-transperineal-prostate-biopsy-in-patients-with-a-previous-negative-biopsy
#6
N L Hansen, C Kesch, T Barrett, B Koo, J P Radtke, D Bonekamp, H P Schlemmer, A Y Warren, K Wieczorek, M Hohenfellner, C Kastner, B Hadaschik
OBJECTIVES: To evaluate the detection rates of targeted and systematic biopsies in magnetic resonance (MRI) and transrectal ultrasound (US) image-fusion transperineal prostate biopsy for patients with previous benign transrectal US guided biopsies in two high-volume centres. PATIENTS AND METHODS: Two centre, prospective outcome study of 487 patients with previous benign biopsies that underwent transperineal MRI/US fusion-guided target and systematic saturation biopsy from 2012 to 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27858090/dramatic-increase-in-the-utilization-of-multiparametric-magnetic-resonance-imaging-for-detection-and-management-of-prostate-cancer
#7
Daniel T Oberlin, David D Casalino, Frank H Miller, Joshua J Meeks
PURPOSE: Multiparametric MRI (mpMRI) of the prostate is an evolving technology that provides functional information of the prostate that helps distinguish benign from malignant lesions. We hypothesized that mpMRI is rapidly adopted in the US to fill the unmet need for a non-invasive, accurate screening tool. The aim of this study is to assess the increasing utilization of mpMRI for the diagnosis and management of prostate cancer. METHODS: We conducted a retrospective review of an institutional clinical data repository of four million patients...
November 17, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27856204/are-dynamic-contrast-enhanced-images-necessary-for-prostate-cancer-detection-on-multiparametric-magnetic-resonance-imaging
#8
Thaís Caldara Mussi, Tatiana Martins, Rodrigo Gobbo Garcia, Renee Zon Filippi, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
BACKGROUND: To compare the results of magnetic resonance imaging (MRI) with and without contrast-enhanced sequences for the detection of clinically significant prostate cancer. The value of contrast in the MRI protocol for the detection of prostate tumors has been discussed in previous studies. MATERIALS AND METHODS: We performed an institutional review board-approved, retrospective study of patients who had undergone prostate MRI followed by fusion biopsy during a 16-month period...
October 18, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27855661/comparison-of-the-complications-of-traditional-12-cores-transrectal-prostate-biopsy-with-image-fusion-guided-transperineal-prostate-biopsy
#9
Haifeng Huang, Wei Wang, Tingsheng Lin, Qing Zhang, Xiaozhi Zhao, Huibo Lian, Hongqian Guo
BACKGROUND: To compare the complications of traditional transrectal (TR) prostate biopsy and image fusion guided transperineal (TP) prostate biopsy in our center. METHODS: Two hundred and fourty-two patients who underwent prostate biopsy from August 2014 to January 2015were reviewed. Among them, 144 patients underwent systematic 12-core transrectal ultrasonography (TRUS) guided prostate biopsy (TR approach) while 98 patients underwent free-hand transperineal targeted biopsy with TRUS and multi-parameter magnetic resonance imaging (mpMRI) fusion images (TP approach)...
November 17, 2016: BMC Urology
https://www.readbyqxmd.com/read/27847972/first-report-of-robot-assisted-transperineal-fusion-versus-off-target-biopsy-in-patients-undergoing-repeat-prostate-biopsy
#10
S Kaufmann, J Mischinger, B Amend, S Rausch, M Adam, M Scharpf, F Fend, U Kramer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
PURPOSE: To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. METHODS: Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System...
November 15, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27844131/-mri-trus-fusion-guided-prostate-biopsy-value-in-the-context-of-focal-therapy
#11
T Franz, J von Hardenberg, A Blana, H Cash, D Baumunk, G Salomon, B Hadaschik, T Henkel, J Herrmann, F Kahmann, K-U Köhrmann, J Köllermann, S Kruck, U-B Liehr, S Machtens, I Peters, J P Radtke, A Roosen, H-P Schlemmer, L Sentker, J J Wendler, U Witzsch, J-U Stolzenburg, M Schostak, R Ganzer
BACKGROUND: Several systems for MRI/TRUS fusion-guided biopsy of the prostate are commercially available. Many studies have shown superiority of fusion systems for tumor detection and diagnostic quality compared to random biopsy. The benefit of fusion systems in focal therapy of prostate cancer (PC) is less clear. OBJECTIVES: Critical considerations of fusion systems for planning and monitoring of focal therapy of PC were investigated. MATERIALS AND METHODS: A systematic literature review of available fusion systems for the period 2013-5/2016 was performed...
November 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27830373/precision-of-mri-ultrasound-fusion-biopsy-in-prostate-cancer-diagnosis-an-ex-vivo-comparison-of-alternative-biopsy-techniques-on-prostate-phantoms
#12
N Westhoff, F P Siegel, D Hausmann, M Polednik, J von Hardenberg, M S Michel, M Ritter
PURPOSE: Comparing the accuracy of MRI/ultrasound-guided target-biopsy by transrectal biopsy (TRB) with elastic versus rigid image fusion versus transperineal biopsy (TPB) with rigid image fusion in a standardized setting. METHODS: Target-biopsy of six differently sized and located lesions was performed on customized CIRS 070L prostate phantoms. Lesions were only MRI-visible. After prior MRI for lesion location, one targeted biopsy per lesion was obtained by TRB with elastic image fusion with Artemis™ (Eigen, USA), TRB with rigid image fusion with real-time virtual sonography (Hitachi, Japan) and TPB with rigid image fusion with a brachytherapy approach (Elekta, Sweden), each on a phantom of 50, 100 and 150 ml prostate volume...
November 9, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27810195/transrectal-implantation-and-stability-of-gold-markers-in-prostate-bed-for-salvage-radiotherapy-of-macroscopic-recurrences
#13
Shakir I Shakir, Corina Udrescu, Ciprian Enachescu, Olivier Rouviere, Simona Arion, Ionela Caraivan, Olivier Chapet
BACKGROUND AND PURPOSE: The objective of the study was to verify the stability of gold markers in the prostatic bed (PB) during salvage radiotherapy. MATERIAL AND METHODS: Seven patients, diagnosed with a macroscopic nodule visible on MRI, underwent targeted MRI-guided biopsies. Three gold markers were implanted into the PB close to the relapsing nodule for CT/MRI fusion. A dose of 60Gy was delivered using IMRT to the PB followed by a dose escalation up to 72Gy to the macroscopic nodule...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27803051/up-regulation-of-mismatch-repair-genes-msh6-pms2-and-mlh1-parallels-development-of-genetic-instability-and-is-linked-to-tumor-aggressiveness-and-early-psa-recurrence-in-prostate-cancer
#14
Waldemar Wilczak, Semin Rashed, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Franziska Büscheck, Till Sebastian Clauditz, Katharina Grupp, Sarah Minner, Maria Christina Tsourlakis, Christina Koop, Markus Graefen, Meike Adam, Alexander Haese, Corinna Wittmer, Guido Sauter, Jakob Robert Izbicki, Hartwig Huland, Thorsten Schlomm, Stefan Steurer, Till Krech, Patrick Lebok
DNA mismatch repair (MMR) is integral to the maintenance of genetic stability. We aimed to evaluate the clinical impact of MMR gene expression in prostate cancer. The MMR genes MSH6, MLH1 and PMS2 were analyzed by immunohistochemistry on a tissue microarray containing 11 152 prostate cancer specimens. Results were compared with ERG status and deletions of PTEN, 3p13, 5q21, and 6q15. MSH6, MLH1 and PMS2 expression was detectable in 89.5%, 85.4% and 85.0% of cancers, and was particularly strong in cancers with advanced pathological tumor stage (p<0...
November 1, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27800057/comparison-of-prostate-mri-3d-transrectal-ultrasound-fusion-biopsy-for-first-time-and-repeat-biopsy-patients-with-previous-atypical-small-acinar-proliferation
#15
Derek W Cool, Cesare Romagnoli, Jonathan I Izawa, Joseph Chin, Lori Gardi, David Tessier, Ashley Mercado, Jonathan Mandel, Aaron D Ward, Aaron Fenster
INTRODUCTION: This study evaluates the clinical benefit of magnetic resonance-transrectal ultrasound (MR-TRUS) fusion biopsy over systematic biopsy between first-time and repeat prostate biopsy patients with prior atypical small acinar proliferation (ASAP). MATERIALS: 100 patients were enrolled in a single-centre prospective cohort study: 50 for first biopsy, 50 for repeat biopsy with prior ASAP. Multiparameteric magnetic resonance imaging (MP-MRI) and standard 12-core ultrasound biopsy (Std-Bx) were performed on all patients...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27792187/prostate-cancer-detection-and-prognosis-from-prostate-specific-antigen-psa-to-exosomal-biomarkers
#16
REVIEW
Xavier Filella, Laura Foj
Prostate specific antigen (PSA) remains the most used biomarker in the management of early prostate cancer (PCa), in spite of the problems related to false positive results and overdiagnosis. New biomarkers have been proposed in recent years with the aim of increasing specificity and distinguishing aggressive from non-aggressive PCa. The emerging role of the prostate health index and the 4Kscore is reviewed in this article. Both are blood-based tests related to the aggressiveness of the tumor, which provide the risk of suffering PCa and avoiding negative biopsies...
October 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27784024/transrectal-ultrasound-guided-prostate-biopsy-for-cancer-detection-performance-of-2d-3d-and-3d-mri-fusion-targeted-techniques
#17
Jacques Klein, Arachk de Górski, Daniel Benamran, Jean-Paul Vallee, Thomas De Perrot, Gregory J Wirth, Christophe E Iselin
INTRODUCTION: The study aimed to evaluate 3 different modalities of transrectal ultrasound (TRUS)-guided prostate biopsies (PBs; 2D-, 3D- and targeted 3D-TRUS with fusion to MRI - T3D). Primary end point was the detection rate of prostate cancer (PC). Secondary end point was the detection rate of insignificant PC according to the Epstein criteria. PATIENTS AND METHODS: Inclusion of 284 subsequent patients who underwent 2D-, 3D- or T3D PB from 2011 to 2015. All patients having PB for initial PC detection with a serum prostate-specific antigen value ≤20 ng/ml were included...
October 27, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27783538/proposed-adjustments-to-pi-rads-version-2-decision-rules-impact-on-prostate-cancer-detection
#18
Andrew B Rosenkrantz, James S Babb, Samir S Taneja, Justin M Ream
Purpose To test the impact of existing Prostate Imaging Reporting and Data System (PI-RADS) version 2 (V2) decision rules, as well as of proposed adjustments to these decision rules, on detection of Gleason score (GS) 7 or greater (GS ≥7) prostate cancer. Materials and Methods Two radiologists independently provided PI-RADS V2 scores for the dominant lesion on 343 prostate magnetic resonance (MR) examinations. Diagnostic performance for GS ≥7 tumor was assessed by using MR imaging-ultrasonography fusion-targeted biopsy as the reference...
October 26, 2016: Radiology
https://www.readbyqxmd.com/read/27778089/comparison-of-initial-and-tertiary-centre-second-opinion-reads-of-multiparametric-magnetic-resonance-imaging-of-the-prostate-prior-to-repeat-biopsy
#19
Nienke L Hansen, Brendan C Koo, Ferdia A Gallagher, Anne Y Warren, Andrew Doble, Vincent Gnanapragasam, Ola Bratt, Christof Kastner, Tristan Barrett
OBJECTIVES: To investigate the value of second-opinion evaluation of multiparametric prostate magnetic resonance imaging (MRI) by subspecialised uroradiologists at a tertiary centre for the detection of significant cancer in transperineal fusion prostate biopsy. METHODS: Evaluation of prospectively acquired initial and second-opinion radiology reports of 158 patients who underwent MRI at regional hospitals prior to transperineal MR/untrasound fusion biopsy at a tertiary referral centre over a 3-year period...
October 24, 2016: European Radiology
https://www.readbyqxmd.com/read/27759826/multiparametric-magnetic-resonance-imaging-findings-of-prostatic-pure-leiomyomas
#20
Thais Caldara Mussi, Yves Bohrer Costa, Marcos Takeo Obara, Marcos Roberto Gomes de Queiroz, Rodrigo Gobbo Garcia, José Antonio Domingos Cianciarulo Longo, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
Objective: To describe the imaging findings of prostatic tumors nonadenocarcinoma on multiparametric magnetic resonance imaging. Methods: A total of 200 patients underwented multiparametric magnetic resonance imaging of the prostate for screening for prostate cancer, from August 2013 to September 2014, followed by biopsy with ultrasound/magnetic resonance imaging fusion. Results: We found three pathologic proved cases of prostatic pure leiomyomas (0...
July 2016: Einstein
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