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https://www.readbyqxmd.com/read/28373441/expression-of-rna-binding-motif-protein-3-rbm3-and-cold-inducible-rna-binding-protein-cirp-is-associated-with-improved-clinical-outcome-in-patients-with-colon-cancer
#1
Ho Hee Jang, Hae Na Lee, So-Young Kim, Suntaek Hong, Won-Suk Lee
BACKGROUND: Recent studies have shown a potential role of RNA-binding proteins (RBPs) in a variety of biological pathways, including cancer progression, whilst their expression in various tumor types may be associated with patient prognosis. However, the role of the RBP family members has not been explored in colon cancer and their possible use as prognostic biomarkers is largely unknown. MATERIALS AND METHODS: To determine the prognostic role of three RBP genes: insulin-like growth factor-binding protein 2 (IGFBP2), RNA-binding motif protein 3 (RBM3), and cold-inducible RNA-binding protein (CIRP) in colon cancer...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28128330/cold-inducible-rna-binding-protein-cirp-causes-sepsis-associated-acute-lung-injury-via-induction-of-endoplasmic-reticulum-stress
#2
Mohammad Moshahid Khan, Weng-Lang Yang, Max Brenner, Alexandra Cerutti Bolognese, Ping Wang
Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) stress is associated with acute lung injury (ALI), we hypothesized that CIRP causes ALI via induction of ER stress. To test this hypothesis, we studied the lungs of wild-type (WT) and CIRP knockout (KO) mice at 20 h after induction of sepsis by cecal ligation and puncture (CLP). WT mice had significantly more severe ALI than CIRP KO mice...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28002126/stress-response-protein-rbm3-promotes-the-development-of-colitis-associated-cancer
#3
Toshiharu Sakurai, Hiroshi Kashida, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Tomohiro Watanabe, Masayuki Kitano, Naoshi Nishida, Jun Fujita, Masatoshi Kudo
BACKGROUND: Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and often results from refractory inflammatory bowel disease (IBD). Stress response proteins Cirp and heat shock protein A4 are involved in the refractory clinical course and development of CAC. RNA-binding motif protein 3 (RBM3) is induced in response to various stresses and is upregulated in several cancers. However, the role of RBM3 in CAC is unclear. METHODS: We assessed RBM3 expression and function in 263 human intestinal mucosa samples from patients with IBD and in Rbm3-deficient (Rbm3) mice...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27977278/international-humanitarian-award
#4
(no author information available yet)
The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2016 recipient of the APA International Humanitarian Award was selected by the 2015 Committee on International Relations in Psychology (CIRP)...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27977275/award-for-distinguished-contributions-to-the-international-advancement-of-psychology
#5
(no author information available yet)
This award is given to individuals who have made sustained and enduring contributions to international cooperation and the advancement of knowledge in psychology. The 2016 recipient of the APA Award for Distinguished Contributions to the International Advancement of Psychology was selected by the 2015 Committee on International Relations in Psychology (CIRP). The members of the 2015 CIRP were Rehman Abdulrehman, PhD (Chair); Gonzalo Bacigalupe, EdD; Silvia S. Canetto, PhD; Amanda Clinton, PhD; Melissa L. Morgan Consoli, PhD; Chryse G...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27930406/stress-response-protein-rbm3-promotes-the-development-of-colitis-associated-cancer
#6
Toshiharu Sakurai, Hiroshi Kashida, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Tomohiro Watanabe, Masayuki Kitano, Naoshi Nishida, Jun Fujita, Masatoshi Kudo
BACKGROUND: Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and often results from refractory inflammatory bowel disease (IBD). Stress response proteins Cirp and HSPA4 are involved in the refractory clinical course and development of CAC. RNA-binding motif protein 3 (RBM3) is induced in response to various stresses and is upregulated in several cancers. However, the role of RBM3 in CAC is unclear. METHODS: We assessed RBM3 expression and function in 263 human intestinal mucosa samples from patients with IBD and in Rbm3-deficient (Rbm3) mice...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27864909/the-mechanism-of-cirp-in-inhibition-of-keratinocytes-growth-arrest-and-apoptosis-following-low-dose-uvb-radiation
#7
Yi Liao, Jianguo Feng, Yi Zhang, Liling Tang, Shiyong Wu
UV induces CIRP expression and subsequent Stat3 activation, but the biological function and mechanism of CIRP and Stat3in mediating UVB-induced skin carcinogenesis have not been fully elucidated. In this study, we demonstrate that CIRP is elevated in all tested melanoma and non-melanoma skin cancer cell lines; and the expression of CIRP is upregulated in keratinocytes after being irradiated with relatively low dose (<5 mJ/cm(2) ), but not high dose (50 mJ/cm(2) ), UVB acutely and chronically. The increased expression of CIRP, either induced by UVB or through overexpression, leads to resistance of keratinocytes to UVB-induced growth arrest and death; and reduced expression of CIRP by RNA knockdown sensitizes keratinocyte cells to the low dose UVB radiation...
November 19, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27830872/cloning-and-expression-of-cold-inducible-rna-binding-protein-in-domestic-yak-bos-grunniens
#8
K Yang, Q Zhang, Z Wen, Y Pan, S Yu, J He, X Yang, P Liu, Y Cui
Cold-inducible RNA binding protein (CIRP) is over-expressed during cold and many other stresses, and could regulate the adaptation to hypothermia. In the present investigation, the objective was to determine the expression of CIRP in adult yak heart, liver, spleen, lung, kidney, brain, ovary, testis and skin by relative quantitative real time polymerase chain reaction (RT-PCR), Western blot and immunohistochemistry from mRNA and protein levels. The CIRP open reading frame encoding was cloned from the domestic yak brain...
2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27569563/cold-inducible-rna-binding-protein-activates-splenic-t-cells-during-sepsis-in-a-tlr4-dependent-manner
#9
Alexandra C Bolognese, Archna Sharma, Weng-Lang Yang, Jeffrey Nicastro, Gene F Coppa, Ping Wang
Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4(+) splenic T cells, and significantly higher CD69 expression on CD8(+) splenic T cells compared with sham-operated controls...
August 29, 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27556928/cold-shock-proteins-are-expressed-in-the-retina-following-exposure-to-low-temperatures
#10
Ignacio M Larrayoz, Manuel Rey-Funes, Daniela S Contartese, Federico Rolón, Anibal Sarotto, Veronica B Dorfman, Cesar F Loidl, Alfredo Martínez
Hypothermia has been proposed as a therapeutic intervention for some retinal conditions, including ischemic insults. Cold exposure elevates expression of cold-shock proteins (CSP), including RNA-binding motif protein 3 (RBM3) and cold inducible RNA-binding protein (CIRP), but their presence in mammalian retina is so far unknown. Here we show the effects of hypothermia on the expression of these CSPs in retina-derived cell lines and in the retina of newborn and adult rats. Two cell lines of retinal origin, R28 and mRPE, were exposed to 32°C for different time periods and CSP expression was measured by qRT-PCR and Western blotting...
2016: PloS One
https://www.readbyqxmd.com/read/27477308/cold-inducible-rna-binding-protein-mediates-airway-inflammation-and-mucus-hypersecretion-through-a-post-transcriptional-regulatory-mechanism-under-cold-stress
#11
Yang Juan, Wu Haiqiao, Wenyao Xie, Huang Huaping, Han Zhong, Zhou Xiangdong, Victor P Kolosov, Juliy M Perelman
Acute or chronic cold exposure exacerbates chronic inflammatory airway diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein and is induced by various environmental stressors, such as hypothermia and hypoxia. In this study, we showed that CIRP gene and protein levels were significantly increased in patients with COPD and in rats with chronic airway inflammation compared with healthy subjects. Similarly, inflammatory cytokine production and MUC5AC secretion were up-regulated in rats following cigarette smoke inhalation...
September 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27423012/cold-inducible-rna-binding-protein-mediates-cold-air-inducible-airway-mucin-production-through-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#12
Lingxiu Chen, Danhua Ran, Wenyue Xie, Qing Xu, Xiangdong Zhou
Mucus overproduction is an important feature in patients with chronic inflammatory airway diseases and cold air stimulation has been shown to be associated with the severity of these diseases. However, the regulatory mechanisms that mediate excessive mucin production under cold stress remain elusive. Recently, the cold-inducible RNA-binding protein (CIRP) has been shown to be markedly induced after exposure to cold air. In this study, we sought to explore the expression of CIRP within bronchial biopsy specimens, the effect on mucin5AC (MUC5AC) production in chronic inflammatory airway diseases and the potential signaling pathways involved in cold air stimulation process...
October 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27395339/cold-inducible-rna-binding-protein-promotes-epithelial-mesenchymal-transition-by-activating-erk-and-p38-pathways
#13
Hae Na Lee, Sung-Min Ahn, Ho Hee Jang
Transforming growth factor-β1 (TGF-β1), a potent inducer of epithelial-to-mesenchymal transition (EMT), upregulates the cold-inducible RNA-binding protein (CIRP). The link between CIRP and EMT, however, remains unknown. To determine the role of CIRP in EMT, we performed CIRP knockdown and overexpression experiments in in vitro TGF-β1-induced EMT models. We found that CIRP overexpression promoted the downregulation of epithelial markers and the upregulation of mesenchymal markers after TGF-β1 treatment for EMT induction...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27364162/cellular-functions-of-rna-binding-motif-protein-3-rbm3-clues-in-hypothermia-cancer-biology-and-apoptosis
#14
REVIEW
Heyam I M Al-Astal, Maram Massad, Manaf AlMatar, Harith Ekal
Cell rapidly adapts to the harsh environment under certain conditions such as hypothermia and stress via activity of certain specific cold-shock proteins. Two cold shock proteins, RNA-binding motif protein 3 (RBM3) and coldinducible RNA binding proteins (CIRP), have been unveiled in human cells. RBM3, which is able to regulate their expression at the level of translation by binding to different transcripts, allows the cell to respond rapidly to environmental signals. Additionally, expression of RBM3 is induced under mild to moderate hypothermia, and stress...
2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27335561/neuroprotective-effects-of-cold-inducible-rna-binding-protein-during-mild-hypothermia-on-traumatic-brain-injury
#15
Guan Wang, Jian-Ning Zhang, Jia-Kui Guo, Ying Cai, Hong-Sheng Sun, Kun Dong, Cheng-Gang Wu
Cold-inducible RNA-binding protein (CIRP), a key regulatory protein, could be facilitated by mild hypothermia in the brain, heart and liver. This study observed the effects of mild hypothermia at 31 ± 0.5°C on traumatic brain injury in rats. Results demonstrated that mild hypothermia suppressed apoptosis in the cortex, hippocampus and hypothalamus, facilitated CIRP mRNA and protein expression in these regions, especially in the hypothalamus. The anti-apoptotic effect of mild hypothermia disappeared after CIRP silencing...
May 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27315340/serum-and-synovial-fluid-concentrations-of-cold-inducible-rna-binding-protein-in-patients-with-rheumatoid-arthritis
#16
In Seol Yoo, Sun Young Lee, Chan Keol Park, Jeong Chan Lee, Young Kim, Su Jin Yoo, Seung Cheol Shim, Yoon Seok Choi, Young Lee, Seong Wook Kang
AIM: There is growing evidence that cold-inducible RNA-binding protein (CIRP) promotes inflammatory responses. This study investigated the relationship between CIRP and rheumatoid arthritis (RA). METHODS: Peripheral blood and synovial fluid were collected from 15 patients with RA and from 16 patients with osteoarthritis (OA). The concentration of CIRP was measured with the sandwich enzyme-linked immunosorbent assay (ELISA). RESULTS: The concentration of serum CIRP was significantly elevated in the RA patient group (RA patients = 26...
June 17, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27267546/deficiency-of-cold-inducible-ribonucleic-acid-binding-protein-reduces-renal-injury-after-ischemia-reperfusion
#17
Cindy Cen, Weng-Lang Yang, Hao-Ting Yen, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
BACKGROUND: Renal ischemia-reperfusion injury, commonly caused by major operation and shock, leads to acute kidney injury and is associated with high morbidity and mortality. Cold-inducible ribonucleic acid-binding protein, a cold shock protein, has recently been identified as a damage-associated molecular pattern. We hypothesized that cold-inducible ribonucleic acid-binding protein exacerbates severity of injury in renal ischemia-reperfusion. METHODS: Renal ischemia was induced in an 8-week-old male C57BL/6 wild-type mice and Cirp(-/-) mice via bilateral clamping of renal pedicles for 30 minutes, followed by reperfusion for 5 or 24 hours and harvest of blood and renal tissue for analysis...
August 2016: Surgery
https://www.readbyqxmd.com/read/27217302/cold-inducible-rna-binding-protein-causes-endothelial-dysfunction-via-activation-of-nlrp3-inflammasome
#18
Weng-Lang Yang, Archna Sharma, Zhimin Wang, Zhigang Li, Jie Fan, Ping Wang
Cold-inducible RNA-binding protein (CIRP) is a damage-associated molecular pattern (DAMP) molecule which stimulates proinflammatory cytokine release in hemorrhage and sepsis. Under these medical conditions, disruption of endothelial homeostasis and barrier integrity, typically induced by proinflammatory cytokines, is an important factor contributing to morbidity and mortality. However, the role of CIRP in causing endothelial dysfunction has not been investigated. In this study, we show that intravenous injection of recombinant murine CIRP (rmCIRP) in C57BL/6 mice causes lung injury, evidenced by vascular leakage, edema, increased leukocyte infiltration and cytokine production in the lung tissue...
May 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27184164/cold-inducible-rna-binding-protein-regulates-mucin-expression-induced-by-cold-temperatures-in-human-airway-epithelial-cells
#19
DanHua Ran, LingXiu Chen, WenYue Xie, Qing Xu, Zhong Han, HuaPing Huang, XiangDong Zhou
Mucus overproduction is an important manifestation of chronic airway inflammatory diseases, however, the mechanisms underlying the association between cold air and mucus overproduction remain unknown. We found that the expression of the cold-inducible RNA binding protein (CIRP) was increased in patients with chronic obstructive pulmonary disease (COPD). In the present study, we tested whether CIRP was involved in inflammatory factors and mucin5AC (MUC5AC) expression after cold stimulation and investigated the potential signaling pathways involved in this process...
August 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27147467/cold-inducible-proteins-cirp-and-rbm3-a-unique-couple-with-activities-far-beyond-the-cold
#20
REVIEW
Xinzhou Zhu, Christoph Bührer, Sven Wellmann
Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are two evolutionarily conserved RNA-binding proteins that are transcriptionally upregulated in response to low temperature. Featuring an RNA-recognition motif (RRM) and an arginine-glycine-rich (RGG) domain, these proteins display many similarities and specific disparities in the regulation of numerous molecular and cellular events. The resistance to serum withdrawal, endoplasmic reticulum stress, or other harsh conditions conferred by RBM3 has led to its reputation as a survival gene...
October 2016: Cellular and Molecular Life Sciences: CMLS
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