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https://www.readbyqxmd.com/read/28390990/selection-of-reference-genes-for-gene-expression-studies-in-heart-failure-for-left-and-right-ventricles
#1
Mengmeng Li, Man Rao, Kai Chen, Jianye Zhou, Jiangping Song
Real-time quantitative reverse transcriptase-PCR (qRT-PCR) is a feasible tool for determining gene expression profiles, but the accuracy and reliability of the results depends on the stable expression of selected housekeeping genes in different samples. By far, researches on stable housekeeping genes in human heart failure samples are rare. Moreover the effect of heart failure on the expression of housekeeping genes in right and left ventricles is yet to be studied. Therefore we aim to provide stable housekeeping genes for both ventricles in heart failure and normal heart samples...
July 15, 2017: Gene
https://www.readbyqxmd.com/read/27966653/the-accessory-proteins-reep5-and-reep6-refine-cxcr1-mediated-cellular-responses-and-lung-cancer-progression
#2
Cho Rong Park, Dong-Joo You, Sumi Park, Sunam Mander, Da-Eun Jang, Su-Cheong Yeom, Seong-Hyun Oh, Curie Ahn, Sang Heon Lee, Jae Young Seong, Jong-Ik Hwang
Some G-protein-coupled receptors have been reported to require accessory proteins with specificity for proper functional expression. In this study, we found that CXCR1 interacted with REEP5 and REEP6, but CXCR2 did not. Overexpression of REEP5 and REEP6 enhanced IL-8-stimulated cellular responses through CXCR1, whereas depletion of the proteins led to the downregulation of the responses. Although REEPs enhanced the expression of a subset of GPCRs, in the absence of REEP5 and REEP6, CXCR1 was expressed in the plasma membrane, but receptor internalization and intracellular clustering of β-arrestin2 following IL-8 treatment were impaired, suggesting that REEP5 and REEP6 might be involved in the ligand-stimulated endocytosis of CXCR1 rather than membrane expression, which resulted in strong cellular responses...
December 14, 2016: Scientific Reports
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