keyword
MENU ▼
Read by QxMD icon Read
search

Fusion biopsy

keyword
https://www.readbyqxmd.com/read/27919653/transperineal-biopsies-of-mri-detected-aggressive-index-lesions-in-low-%C3%A2-and-intermediate-risk-prostate-cancer-patients-implications-for-treatment-decision
#1
A Gomez-Iturriaga, F Casquero, J I Lopez, A Urresola, A Ezquerro, D Buscher, P Bilbao, J Crook
PURPOSE: Multiparametric MRI (mpMRI) has a potential role for the identification of aggressive cancer that can be targeted for biopsy. We report the incidence and severity of discordant information between the pathology found on the transrectal ultrasound (TRUS)-guided biopsy and the mpMRI findings in patients with favorable or intermediate-risk prostate cancer referred for brachytherapy. METHODS AND MATERIALS: From March 2014 to September 2015, 10/44 consecutive patients with low- or intermediate-risk prostate cancer referred for brachytherapy presented an aggressive lesion on mpMRI and underwent an MRI-TRUS fusion-guided transperineal biopsy of the index lesion...
December 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27914184/the-potential-use-of-ultrasound-magnetic-resonance-imaging-fusion-applications-in-musculoskeletal-intervention
#2
Christopher J Burke, Jenny Bencardino, Ronald Adler
We sought to assess the potential use of an application allowing real-time ultrasound spatial registration with previously acquired magnetic resonance imaging in musculoskeletal procedures. The ultrasound fusion application was used to perform a range of outpatient procedures including piriformis, sacroiliac joint, pudendal and intercostal nerve perineurial injections, hamstring-origin calcific tendonopathy barbotage, and 2 soft tissue biopsies at our institution in 2015. The application was used in a total of 7 procedures in 7 patients, all of which were technically successful...
December 3, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#3
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27882057/robotic-assisted-laparoscopic-prostatectomy-performed-after-previous-suprapubic-prostatectomy
#4
Johnson F Tsui, Michael Feuerstein, Seyed Behzad Jazayeri, David B Samadi
Operative management of prostate cancer in a patient who has undergone previous open suprapubic simple prostatectomy poses a unique surgical challenge. Herein, we describe a case of intermediate risk prostate cancer in a man who had undergone simple prostatectomy ten years prior to presentation. The patient was found to have Gleason 7 prostate cancer on MRI fusion biopsy of the prostate for elevated PSA and underwent an uncomplicated robot assisted laparoscopic radical prostatectomy.
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27871829/the-role-of-ipsilateral-and-contralateral-trus-guided-systematic-prostate-biopsy-in-men-with-unilateral-mri-lesion-undergoing-mri-us-fusion-targeted-prostate-biopsy
#5
Darren J Bryk, Elton Llukani, Samir S Taneja, Andrew B Rosenkrantz, William C Huang, Herbert Lepor
OBJECTIVE: To determine how ipsilateral (ipsi) and contralateral (contra) systematic biopsies (SB) impacts detection of clinically significant versus insignificant prostate cancer (PCa) in men with unilateral MRI lesion undergoing MRI fusion target biopsy (MRF-TB). MATERIALS AND METHODS: 211 cases with one unilateral MRI lesion were subjected to SB and MRF-TB. Biopsy tissue cores from the MRF-TB, ipsi-SB and contra-SB were analyzed separately. RESULTS: A direct relationship was observed between MRI suspicious score (SS) and detection of any cancer, Gleason 6 PCa and Gleason > 6 PCa...
November 18, 2016: Urology
https://www.readbyqxmd.com/read/27865795/hepatic-angiomyolipomas-may-overexpress-tfe3-but-have-no-relevant-genetic-alterations
#6
Naoe Jimbo, Takashi Nishigami, Masayuki Noguchi, Hiroko Iijima, Seiichi Hirota, Takuma Tajiri, Takeshi Inoue, Takanori Hirose, Tomoo Itoh, Yoh Zen
The fusion or amplification of TFE3 has been identified as one of the molecular events underlying tumorigenesis in perivascular epithelioid cell tumors (PEComas). TFE3 rearrangements in PEComas are related to the morphological features of the epithelioid appearance and weaker expression of immunohistochemical muscular markers. This study aimed to clarify whether these genetic alterations are involved in hepatic angiomyolipomas (AMLs), which are a member of the PEComa tumor family. We examined 28 liver specimens (15 biopsies and 13 surgical specimens) of hepatic AMLs obtained from 26 patients...
November 16, 2016: Human Pathology
https://www.readbyqxmd.com/read/27865106/high-speed-biosensing-strategy-for-non-invasive-profiling-of-multiple-cancer-fusion-genes-in-urine
#7
Kevin M Koo, Eugene J H Wee, Matt Trau
Aberrant chromosal rearrangements, such as the multiple variants of TMPRSS2:ERG fusion gene mutations in prostate cancer (PCa), are promising diagnostic and prognostic biomarkers due to their specific expression in cancerous tissue only. Additionally, TMPRSS2:ERG variants are detectable in urine to provide non-invasive PCa diagnostic sampling as an attractive surrogate for needle biopsies. Therefore, rapid and simplistic assays for identifying multiple urinary TMPRSS2:ERG variants are potentially useful to aid in early cancer detection, immediate patient risk stratification, and prompt personalized treatment...
November 12, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27864107/should-hypoechoic-lesions-on-trus-be-sampled-during-mri-targeted-prostate-biopsy
#8
Nabeel A Shakir, M Minhaj Siddiqui, Arvin K George, Michael Kongnyuy, Richard Ho, Michele Fascelli, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
OBJECTIVES: To determine whether supplemental biopsy of hypoechoic ultrasound lesions (HUL) incidentally found during MRI-transrectal ultrasound (TRUS) fusion-targeted prostate biopsy results in improved prostate cancer (PCa) detection. METHODS: Patients underwent MRI-TRUS targeted biopsy as part of an ongoing prospective trial from August 2007 to February 2015. For men with HUL, the biopsy pathology of HUL and MRI lesions was classified according to the updated 2014 International Society of Urological Pathology (ISUP) grading system...
November 15, 2016: Urology
https://www.readbyqxmd.com/read/27863505/a-genomic-case-study-of-desmoplastic-small-round-cell-tumor-comprehensive-analysis-reveals-insights-into-potential-therapeutic-targets-and-development-of-a-monitoring-tool-for-a-rare-and-aggressive-disease
#9
Elisa Napolitano Ferreira, Bruna Durães Figueiredo Barros, Jorge Estefano de Souza, Renan Valieris Almeida, Giovana Tardin Torrezan, Sheila Garcia, Ana Cristina Victorino Krepischi, Celso Abdon Lopes de Mello, Isabela Werneck da Cunha, Clóvis Antonio Lopes Pinto, Fernando Augusto Soares, Emmanuel Dias-Neto, Ademar Lopes, Sandro José de Souza, Dirce Maria Carraro
BACKGROUND: Genome-wide profiling of rare tumors is crucial for improvement of diagnosis, treatment, and, consequently, achieving better outcomes. Desmoplastic small round cell tumor (DSRCT) is a rare type of sarcoma arising from mesenchymal cells of abdominal peritoneum that usually develops in male adolescents and young adults. A specific translocation, t(11;22)(p13;q12), resulting in EWS and WT1 gene fusion is the only recurrent molecular hallmark and no other genetic factor has been associated to this aggressive tumor...
November 18, 2016: Human Genomics
https://www.readbyqxmd.com/read/27863497/next-generation-sequencing-facilitates-detection-of-the-classic-e13-a20-eml4-alk-fusion-in-an-alk-fish-ihc-inconclusive-biopsy-of-a-stage-iv-lung-cancer-patient-a-case-report
#10
Anna-Lena Volckmar, Volker Endris, Farastuk Bozorgmehr, Clemens Lier, Carlota Porcel, Martina Kirchner, Jonas Leichsenring, Roland Penzel, Michael Thomas, Peter Schirmacher, Arne Warth, Albrecht Stenzinger
BACKGROUND: Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these patients, there is accumulating evidence that other methods of detection, i.e., immunohistochemistry and next-generation sequencing (NGS), exist that may be equally successful. However, the concordance of these methods is under investigation. CASE PRESENTATION: Adding to the current literature, we here report a 56 year old female never-smoker with stage IV lung adenocarcinoma whose biopsy was IHC and FISH inconclusive but positive in NGS...
November 18, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27862869/multicentre-evaluation-of-target-and-systematic-biopsies-using-magnetic-resonance-and-ultrasound-image-fusion-guided-transperineal-prostate-biopsy-in-patients-with-a-previous-negative-biopsy
#11
N L Hansen, C Kesch, T Barrett, B Koo, J P Radtke, D Bonekamp, H P Schlemmer, A Y Warren, K Wieczorek, M Hohenfellner, C Kastner, B Hadaschik
OBJECTIVES: To evaluate the detection rates of targeted and systematic biopsies in magnetic resonance (MRI) and transrectal ultrasound (US) image-fusion transperineal prostate biopsy for patients with previous benign transrectal US guided biopsies in two high-volume centres. PATIENTS AND METHODS: Two centre, prospective outcome study of 487 patients with previous benign biopsies that underwent transperineal MRI/US fusion-guided target and systematic saturation biopsy from 2012 to 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27859477/primary-cutaneous-adenoid-cystic-carcinoma-with-myb-aberrations-report-of-three-cases-and-comprehensive-review-of-the-literature
#12
Carlos N Prieto-Granada, Lei Zhang, Cristina R Antonescu, Jean M Henneberry, Jane L Messina
Adenoid cystic carcinoma (ACC) is a relatively rare slow-growing and often-aggressive epithelial-myoepithelial neoplasm that arises in multiple organs including the skin. The t(6;9) (q22-23;p23-24) translocation, resulting in a MYB-NFIB gene fusion has been found in ACCs from the salivary glands and other organs. Recently, MYB aberrations occurring in a subset (40%) of primary cutaneous ACC (PCACC) examples was described. Herein, we report three additional cases of PCACC harboring MYB aberrations. The tumors presented in three males aged 43, 81 and 55 years old and affected the extremities in the first two patients and the scalp in the third one...
November 8, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27858090/dramatic-increase-in-the-utilization-of-multiparametric-magnetic-resonance-imaging-for-detection-and-management-of-prostate-cancer
#13
Daniel T Oberlin, David D Casalino, Frank H Miller, Joshua J Meeks
PURPOSE: Multiparametric MRI (mpMRI) of the prostate is an evolving technology that provides functional information of the prostate that helps distinguish benign from malignant lesions. We hypothesized that mpMRI is rapidly adopted in the US to fill the unmet need for a non-invasive, accurate screening tool. The aim of this study is to assess the increasing utilization of mpMRI for the diagnosis and management of prostate cancer. METHODS: We conducted a retrospective review of an institutional clinical data repository of four million patients...
November 17, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27857933/retro-odontoid-pseudotumor-without-atlantoaxial-subluxation-or-rheumatic-arthritis
#14
Seung Han Yu, Hyuk Jin Choi, Won Ho Cho, Seung Heon Cha, In Ho Han
We present a case of retro-odontoid pseudotumor (ROP) without rheumatoid arthritis (RA) or atlantoaxial subluxation (AAS). A 76-year-old woman presented with paresthesia and weakness of both lower and upper extremities. She had no laboratory or physical findings of RA. Dynamic X-ray showed no AAS and magnetic resonance imaging (MRI) showed a retro-odontoid mass compressing the spinal cord. Transdural mass debulking and biopsy were performed via minimal left suboccipital craniectomy and C1 hemilaminectomy. Two months after surgery, her symptoms were aggravated...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27856204/are-dynamic-contrast-enhanced-images-necessary-for-prostate-cancer-detection-on-multiparametric-magnetic-resonance-imaging
#15
Thaís Caldara Mussi, Tatiana Martins, Rodrigo Gobbo Garcia, Renee Zon Filippi, Gustavo Caserta Lemos, Ronaldo Hueb Baroni
BACKGROUND: To compare the results of magnetic resonance imaging (MRI) with and without contrast-enhanced sequences for the detection of clinically significant prostate cancer. The value of contrast in the MRI protocol for the detection of prostate tumors has been discussed in previous studies. MATERIALS AND METHODS: We performed an institutional review board-approved, retrospective study of patients who had undergone prostate MRI followed by fusion biopsy during a 16-month period...
October 18, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27855661/comparison-of-the-complications-of-traditional-12-cores-transrectal-prostate-biopsy-with-image-fusion-guided-transperineal-prostate-biopsy
#16
Haifeng Huang, Wei Wang, Tingsheng Lin, Qing Zhang, Xiaozhi Zhao, Huibo Lian, Hongqian Guo
BACKGROUND: To compare the complications of traditional transrectal (TR) prostate biopsy and image fusion guided transperineal (TP) prostate biopsy in our center. METHODS: Two hundred and fourty-two patients who underwent prostate biopsy from August 2014 to January 2015were reviewed. Among them, 144 patients underwent systematic 12-core transrectal ultrasonography (TRUS) guided prostate biopsy (TR approach) while 98 patients underwent free-hand transperineal targeted biopsy with TRUS and multi-parameter magnetic resonance imaging (mpMRI) fusion images (TP approach)...
November 17, 2016: BMC Urology
https://www.readbyqxmd.com/read/27847972/first-report-of-robot-assisted-transperineal-fusion-versus-off-target-biopsy-in-patients-undergoing-repeat-prostate-biopsy
#17
S Kaufmann, J Mischinger, B Amend, S Rausch, M Adam, M Scharpf, F Fend, U Kramer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
PURPOSE: To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. METHODS: Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System...
November 15, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27847330/altered-mitochondrial-quality-control-signaling-in-muscle-of-old-gastric-cancer-patients-with-cachexia
#18
Emanuele Marzetti, Maria Lorenzi, Francesco Landi, Anna Picca, Fausto Rosa, Fabiana Tanganelli, Marco Galli, Giovanni Battista Doglietto, Fabio Pacelli, Matteo Cesari, Roberto Bernabei, Riccardo Calvani, Maurizio Bossola
Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia (CC). Whether mitochondrial quality control (MQC) is altered in skeletal myocytes of old patients with CC is unclear. The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of old gastric cancer patients with cachexia. The study followed a case-control cross-sectional design. Intraoperative biopsies of the rectus abdominis muscle were obtained from 18 patients with gastric adenocarcinoma (nine with CC and nine non-cachectic) and nine controls, and assayed for the expression of a set of MQC mediators...
November 12, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27844131/-mri-trus-fusion-guided-prostate-biopsy-value-in-the-context-of-focal-therapy
#19
T Franz, J von Hardenberg, A Blana, H Cash, D Baumunk, G Salomon, B Hadaschik, T Henkel, J Herrmann, F Kahmann, K-U Köhrmann, J Köllermann, S Kruck, U-B Liehr, S Machtens, I Peters, J P Radtke, A Roosen, H-P Schlemmer, L Sentker, J J Wendler, U Witzsch, J-U Stolzenburg, M Schostak, R Ganzer
BACKGROUND: Several systems for MRI/TRUS fusion-guided biopsy of the prostate are commercially available. Many studies have shown superiority of fusion systems for tumor detection and diagnostic quality compared to random biopsy. The benefit of fusion systems in focal therapy of prostate cancer (PC) is less clear. OBJECTIVES: Critical considerations of fusion systems for planning and monitoring of focal therapy of PC were investigated. MATERIALS AND METHODS: A systematic literature review of available fusion systems for the period 2013-5/2016 was performed...
November 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27837193/intact-initiation-of-autophagy-and-mitochondrial-fission-by-acute-exercise-in-skeletal-muscle-of-patientswith-type-2-diabetes
#20
Rikke Kruse, Andreas J T Pedersen, Jonas M Kristensen, Stine J Petersson, Jørgen F P Wojtaszewski, Kurt Højlund
AIMS: Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation, and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy and mitochondrial dynamics during exercise and recovery is important for skeletal muscle homeostasis, and these responses may be altered in T2D. MATERIALS AND METHODS: We examined the effect of acute exercise on markers of autophagy and mitochondrial fusion and fission in skeletal muscle biopsies from patients with T2D (n=13) and weight-matched controls (n=14) before, immediately after and 3h after an acute bout of exercise...
November 11, 2016: Clinical Science (1979-)
keyword
keyword
82987
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"