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https://www.readbyqxmd.com/read/29133573/the-rars-mad1l1-fusion-gene-induces-cancer-stem-cell-like-properties-and-therapeutic-resistance-in-nasopharyngeal-carcinoma
#1
Qian Zhong, Zhihua Liu, Zhi-Rui Lin, Ze-Dong Hu, Li Yuan, Yan-Min Liu, Ai-Jun Zhou, Li-Hua Xu, Li-Juan Hu, Zi-Feng Wang, Xin Yuan Guan, Jia-Jie Hao, Vivian Wai Yan Lui, Ling Guo, Hai-Qiang Mai, Ming-Yuan Chen, Fei Han, Yun-Fei Xia, Jennifer R Grandis, Xing Zhang, Mu-Sheng Zeng
PURPOSE: Nasopharyngeal carcinoma (NPC) is most common head and neck cancer in Southeast Asia. Because local recurrence and distant metastasis are still the main causes of NPC treatment failure, it is urgent to identify new tumor markers and therapeutic targets for advanced NPC. EXPERIMENTAL DESIGN: RNA-seq was applied to look for interchromosome translocation in NPC. PCR, FISH and immunoprecipitation were used to examine the fusion gene expression at RNA, DNA, and protein levels in NPC biopsies...
November 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29127096/retention-of-interstitial-genes-between-tmprss2-and-erg-is-associated-with-low-risk-prostate-cancer
#2
Stephen J Murphy, Farhad Kosari, R Jeffrey Karnes, Aqsa Nasir, Sarah H Johnson, Athanasios G Gaitatzes, James B Smadbeck, Laureano J Rangel, George Vasmatzis, John C Cheville
TMPRSS2-ERG gene fusions occur in over 50% of prostate cancers, but their impact on clinical outcomes is not well understood. Retention of interstitial genes between TMPRSS2 and ERG has been reported to influence tumor progression in an animal model. In this study, we analyzed the status of TMPRSS2-ERG fusion genes and interstitial genes in tumors from a large cohort of men treated surgically for prostate cancer, associating alterations with biochemical progression. Through whole-genome mate pair sequencing, we mapped and classified rearrangements driving ETS family gene fusions in 133 cases of very low-, low-, intermediate-, and high-risk prostate cancer from radical prostatectomy specimens...
November 10, 2017: Cancer Research
https://www.readbyqxmd.com/read/29126575/validation-of-prostate-imaging-reporting-and-data-system-version-2-a-retrospective-analysis
#3
Michael Nguyentat, Alexander Ushinsky, Alessandra Miranda-Aguirre, Edward Uchio, Chandana Lall, Layla Shirkhoda, Thomas Lee, Christopher Green, Roozbeh Houshyar
PURPOSE: Use of magnetic resonance imaging (MRI)/transrectal ultrasound fusion biopsies to determine the accuracy of multiparametric MRI (mpMRI), using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2), for detecting clinically significant prostate cancer in the overall gland and specifically the peripheral zone (PZ) and transitional zone (TZ). METHODS: A retrospective analysis of patients who underwent fusion biopsy identified 137 men with 231 prostate lesions was approved by the Institutional Review Board...
October 12, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29125872/impaired-placental-autophagy-in-placental-malaria
#4
Kris Genelyn Dimasuay, Lan Gong, Fredrick Rosario, Emma McBryde, Tim Spelman, Jocelyn Glazier, Stephen J Rogerson, James G Beeson, Thomas Jansson, Rodney J Devenish, Philippe Boeuf
BACKGROUND: Placental malaria is a major cause of low birthweight, principally due to impaired fetal growth. Intervillositis, a local inflammatory response to placental malaria, is central to the pathogenesis of poor fetal growth as it impairs transplacental amino acid transport. Given the link between inflammation and autophagy, we investigated whether placental malaria-associated intervillositis increased placental autophagy as a potential mechanism in impaired fetal growth. METHODS: We examined placental biopsies collected after delivery from uninfected women (n = 17) and from women with Plasmodium falciparum infection with (n = 14) and without (n = 7) intervillositis...
2017: PloS One
https://www.readbyqxmd.com/read/29112469/risk-of-clinically-significant-prostate-cancer-associated-with-prostate-imaging-reporting-and-data-system-category-3-equivocal-lesions-identified-on-multiparametric-prostate-mri
#5
Alison D Sheridan, Sameer K Nath, Jamil S Syed, Sanjay Aneja, Preston C Sprenkle, Jeffrey C Weinreb, Michael Spektor
OBJECTIVE: The objective of this study is to determine the frequency of clinically significant cancer (CSC) in Prostate Imaging Reporting and Data System (PI-RADS) category 3 (equivocal) lesions prospectively identified on multiparametric prostate MRI and to identify risk factors (RFs) for CSC that may aid in decision making. MATERIALS AND METHODS: Between January 2015 and July 2016, a total of 977 consecutively seen men underwent multiparametric prostate MRI, and 342 underwent MRI-ultrasound (US) fusion targeted biopsy...
November 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29107353/ultrasound-imaging-technologies-for-breast-cancer-detection-and-management-a-review
#6
REVIEW
Rongrong Guo, Guolan Lu, Binjie Qin, Baowei Fei
Ultrasound imaging is a commonly used modality for breast cancer detection and diagnosis. In this review, we summarize ultrasound imaging technologies and their clinical applications for the management of breast cancer patients. The technologies include ultrasound elastography, contrast-enhanced ultrasound, 3-D ultrasound, automatic breast ultrasound and computer-aided detection of breast ultrasound. We summarize the study results seen in the literature and discuss their future directions. We also provide a review of ultrasound-guided, breast biopsy and the fusion of ultrasound with other imaging modalities, especially magnetic resonance imaging (MRI)...
October 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29107112/the-emerging-role-of-exosome-derived-non-coding-rnas-in-cancer-biology
#7
Qing Fan, Shibo Wei, Liang Yang, Xiaodong Zhang, Xueqiang Peng, Dongming Su, Zhenhua Zhai, Xiangdong Hua, Hangyu Li
Exosomes are a new means of intercellular information exchange that have aroused great research interest. Long neglected in research, exosomes were deemed nonfunctional cellular components to be discarded. However, it has been gradually revealed that exosomes are an important tool for the exchange of intercellular information and material. Exosomes contain specific repertoires of non-coding RNAs (ncRNAs, including microRNA and lncRNA), indicating that a specific RNA sorting mechanism may exist. Correspondingly, intracellular multivesicular bodies (MVBs) are produced after fusion with the cell membrane to release exosomes rather than inducing autophagy, which reveals that there may be a specific regulatory mechanism for MVB secretion...
October 26, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29100675/skull-base-plasmacytoma-a-unique-case-of-poems-syndrome-with-a-plasmacytoma-causing-craniocervical-instability
#8
Hannah Gilder, Meghan E Murphy, Mohammed Ali Alvi, Panagiotis Kerezoudis, Daniel Shepherd, Patrick R Maloney, Michael J Yaszemski, Jonathan M Morris, Angela Dispenzieri, Jane M Matsumoto, Mohamad Bydon
INTRODUCTION: Plasmacytomas, considered to be the solitary counterparts of multiple myeloma, are neoplastic monoclonal plasma cell proliferations within soft tissue or bone. Plasmacytomas often present as a collection of findings known as POEMS-syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein spike, and Skin changes). CASE DESCRIPTION: We present a report of a 47 yo male diagnosed with POEMS-syndrome secondary to a skull base plasmacytoma. The mass resulted in marked instability of the cranio-cervical junction due to bony erosion...
October 31, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29094042/evaluation-of-mri-ultrasound-fusion-guided-prostate-biopsy-using-transrectal-and-transperineal-approaches
#9
Susanne Tewes, Inga Peters, Ansgar Tiemeyer, Matti Peperhove, Dagmar Hartung, Stefanie Pertschy, Markus A Kuczyk, Frank Wacker, Katja Hueper
Purpose: To evaluate transrectal (TR) and transperineal (TP) approaches for MRI/ultrasound (MRI/US) fusion-guided biopsy to detect prostate cancer (PCa). Materials and Methods: 154 men underwent multiparametric MRI and MRI/US fusion-guided biopsy between July 2012 and October 2016. 79/154 patients were biopsied with a TR approach and 75/154 with a TP approach. MRI was retrospectively analyzed according to PI-RADS version 2. PI-RADS scores were compared with histopathological results...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29084410/significance-of-mri-transrectal-ultrasound-fusion-three-dimensional-model-guided-targeted-biopsy-based-on-transrectal-ultrasound-guided-systematic-biopsy-in-prostate-cancer-detection-a-systematic-review-and-meta-analysis
#10
Yongquan Tang, Zhihong Liu, Liangyou Tang, Ruochen Zhang, Yiping Lu, Jiayu Liang, Zijun Zou, Chuan Zhou, Yujie Wang
PURPOSE: To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). METHODS: Pubmed and Web of science were searched. Studies with men having a suspicious lesion on MRI were included, which were divided into initial biopsy, previous negative biopsy, and mixed groups in meta-analysis. RESULTS: Totally 13 cohorts in 12 studies, with 3,225 men were included...
October 30, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29083999/multiparametric-mri-fusion-guided-biopsy-for-the-diagnosis-of-prostate-cancer
#11
Claudia Kesch, Viktoria Schütz, Svenja Dieffenbacher, David Bonekamp, Boris Alexander Hadaschik, Markus Hohenfellner, Jan P Radtke
PURPOSE OF REVIEW: To discuss the timing, benefits, limitations and current controversies of multiparametric magnet resonance imaging (mpMRI) combined with fusion-guided biopsy and consider how additional incorporation of multivariable risk stratification might further improve prostate cancer diagnosis. RECENT FINDINGS: MpMRI has been proven advantageous over standard practice for biopsy-naïve men and men with previous biopsy in large prospective studies providing level 1b evidence...
October 27, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29082051/primary-cutaneous-follicle-centre-lymphoma-with-hodgkin-and-reed-sternberg-like-cells-a-case-report-and-review-of-the-literature
#12
Fatima A Aldarweesh, Diana O Treaba
An elderly woman with a complex medical history presented with a left forearm mass that slowly developed for several months. The excisional biopsy of this skin mass was remarkable for involvement by a follicle centre cell derived lymphoma with a nodular and diffuse pattern associated with a subset of scattered Hodgkin and Reed-Sternberg like cells. Fluorescence in situ hybridization studies did not detect the presence of IgH-bcl2 fusion transcript, and molecular studies were negative for immunoglobulin heavy chain gene rearrangements and EBV DNA sequences...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29081861/role-of-surgery-in-management-of-osteo-articular-tuberculosis-of-the-foot-and-ankle
#13
REVIEW
Mandeep Singh Dhillon, Vikas Agashe, Sampat Dumbre Patil
BACKGROUND: Tuberculosis of the foot and ankle still remains to be a significant problem, especially in the developing countries, and with an increase in incidence in immunosuppressed patients. Treatment is mainly medical using multidrug chemotherapy; surgical interventions range from biopsy, synovectomy and debridement, to joint preserving procedures like distraction in early cases, and arthrodesis of hindfoot joints and the ankle in advanced disease with joint destruction. Surgical Options: All procedures should be done after initiating appropriate medical management...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29079986/percutaneous-image-guided-core-biopsy-of-solid-renal-masses-analysis-of-safety-efficacy-pathologic-interpretation-and-clinical-significance
#14
Nisha Alle, Nelly Tan, Julie Huss, Jiatoi Huang, Allan Pantuck, Steven S Raman
PURPOSE: To determine the efficacy, safety and clinical utility of CT and US-guided percutaneous renal mass biopsy. MATERIALS AND METHODS: A retrospective IRB-approved, HIPAA-compliant study of a cohort of 183 consecutive patients who underwent percutaneous, CT or US-guided renal mass biopsy (RMB) from March 2002 through December 2012 was performed. RMB was performed in 183 consecutive patients for suspected solid renal mass of whom 14/183 (7.7%) were excluded because biopsies were performed at an outside institution, medical records were incomplete, or lesions were poorly visualized...
October 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29076874/clear-cell-carcinoma-of-salivary-glands-is-frequently-p16-positive-a-pitfall-in-the-interpretation-of-oropharyngeal-biopsies
#15
Justin A Bishop, Lisa M Rooper, Simion I Chiosea, William H Westra
Clear cell carcinoma (CCC) is a low-grade malignancy that commonly arises in minor salivary glands of the oropharynx and other sites. EWSR1-ATF1 gene fusions seem to be specific for this salivary neoplasm. Testing for EWSR1-ATF1 has expanded the histologic spectrum of CCC. As one important example, many CCCs have a predominantly squamous phenotype with few clear cells, a finding that can cause confusion with squamous cell carcinoma (SqCC). P16 immunohistochemical staining to determine human papillomavirus (HPV) status has become standard practice for all oropharyngeal carcinomas showing squamous differentiation...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29075977/mri-us-fusion-guided-biopsy-performing-exclusively-targeted-biopsies-for-the-early-detection-of-prostate-cancer
#16
Maurizio Del Monte, Leonardo Costantino, Vincenzo Salvo, Marcello Domenico Grompone, Martina Pecoraro, Arnaldo Stanzione, Riccardo Campa, Francesco Vullo, Alessandro Sciarra, Carlo Catalano, Valeria Panebianco
PURPOSE: The aim of this study was to validate the role of MR/Ultrasound Fusion-Guided Targeted Biopsy as a first diagnostic modality in subjects with clinical suspicion of prostate cancer (PCa). MATERIALS AND METHODS: 108 men (age range 46-78 years) with clinical suspicion for PCa (PSA > 4 ng/mL) underwent multiparametric MRI of the prostate (mpMRI) and, when suspicious lesion were found (according to the PIRADSv2 scoring system), targeted biopsy was performed...
October 26, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29075538/an-unsuspected-finding-of-t-9-22-a-rare-case-of-philadelphia-chromosome-positive-b-lymphoblastic-lymphoma
#17
Prajwal Boddu, C Cameron Yin, Rashmi Kanagal-Shamanna, Guillin Tang, Beenu Thakral, Tapan Kadia, Marina Konopleva, Elias Jabbour, Nitin Jain
While rare, cases of isolated extramedullary disease of B-cell Lymphoblastic Lymphoma (B-LBL) without morphologic bone marrow involvement have been described. In this report, we illustrate the case of an elderly gentleman who presented with isolated testicular and vertebral LBL involvement but had no morphologic bone marrow involvement. The initial plan of treatment was to treat along the lines of Philadelphia negative B-ALL/LBL. During this time, fluorescence in situ hybridization (FISH) and PCR testing for BCR-ABL1 rearrangements were being performed on the marrow specimens as a part of routine diagnostic workup...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29074136/new-approach-to-guide-target-prostate-biopsy-technique-and-initial-experience
#18
Enrique Gómez Gómez, José Valero Rosa, Julia Carrasco Valiente, Francisco Triviño Tarradas, Francisco Anglada Curado, Daniel López Ruiz, María José Requena Tapia
OBJECTIVE: To describe the technique of transrectal biopsy with a new device that fuses multiparametric magnetic resonance (mpMRI) and ultrasound images in real time to guide target biopsies and to evaluate our initial experience. METHODS: Patients with persistent suspicion of prostate cancer despite a previous negative biopsy and who had an mpMRI before the biopsy were selected. All patients underwent target biopsy plus standard systematic biopsy. Significant prostate cancer (sig PCa) was defined according to the Epstein criteria for standard biopsy and Gleason grade of >7 and a positive core length of >5 mm for target biopsy...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/29064653/prostate-cancer-recurrence-in-vas-deferens-fusion-image-guide-as-an-important-tool-in-dignosis
#19
Leonardo Guedes Moreira Valle, Antônio Rahal, Priscila Mina Falsarella, Juliano Ribeiro de Andrade, Oren Smaletz, Akemi Osawa, Rodrigo Gobbo Garcia
The biochemical recurrence after local treatment for prostate cancer is an often challenging condition of clinical management. The aim of this report is to demonstrate the importance of the association of various imaging methods in the identification and subsequent accurate percutaneous biopsy in patients with recurrence of prostate cancer, especially in unusual sites. An 86 years old male with biochemical recurrence, during radiological investigation a PET-MRI was noted the presence of an asymmetry of the vas deferens with PSMA- 68Ga uptaken, suggesting the recurrence...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29050721/acute-kidney-injury-secondary-to-cell-saver-in-posterior-spinal-fusion
#20
Anas A Minkara, Albert Y Lin, Michael G Vitale, David P Roye
BACKGROUND: Autologous blood transfusion, commonly referred to as cell saver, is frequently used in spinal fusion to salvage red blood cells because of the risk of significant intraoperative blood loss. This case report describes a case of acute kidney injury (AKI) secondary to cell saver use. Our objective is to increase the knowledge about the process of red blood cell salvage and this exceedingly rare complication. METHODS: Chart and renal biopsy results for a single case were reviewed and reported in this retrospective study...
November 2017: Spine Deformity
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