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https://www.readbyqxmd.com/read/28932542/the-value-of-cell-block-based-on-fine-needle-aspiration-for-lung-cancer-diagnosis
#1
Zhengwei Dong, Hui Li, Jun Zhou, Wei Zhang, Chunyan Wu
BACKGROUND: Computed tomography (CT)-guided percutaneous lung fine needle aspiration (FNA) is a convenient method to obtain samples from pulmonary lesions. FNA has a lower rate of complications than the use of a core needle biopsy, but is more difficult for the diagnosis of cytological samples. We use cell block (CB) and immunocytochemistry (ICC) to improve the accuracy of cytological diagnoses based on CT-guided percutaneous lung FNA. METHODS: We collected 526 cytological samples obtained using CT-guided percutaneous lung FNA at Shanghai Pulmonary Hospital from May 2015 to October 2015...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28921850/prospective-comparison-of-transperineal-mri-ultrasound-fusion-biopsy-and-transrectal-systematic-biopsy-in-biopsy-na%C3%A3-ve-patients
#2
Angelika Borkowetz, Boris Hadaschik, Ivan Platzek, Marieta Toma, Georgi Torsev, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo Baretton, Jan Philipp Radtke, Claudia Kesch, Markus Hohenfellner, Michael Froehner, Heinz-Peter Schlemmer, Manfred Wirth, Stefan Zastrow
OBJECTIVES: To evaluate the value of multiparametric magnetic resonance imaging (mpMRI) for the detection of significant prostate cancer (PCa) and to compare transperineal MRI/ultrasound-fusion biopsy (fusPbx) to conventional transrectal systematic biopsy (sysPbx) in biopsy-naïve patients. PATIENTS AND METHODS: This multicentre, prospective trial investigated biopsy-naïve patients with suspicion of PCa undergoing transperineal fusPbx in combination with transrectal sysPbx (comPbx)...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28900498/correlation-between-erg-fusion-protein-and-androgen-receptor-expression-by-immunohistochemistry-in-prostate-possible-role-in-diagnosis-and-therapy
#3
Amir Hassan Navaei, Beatriz A Walter, Vanessa Moreno, Svetlana D Pack, Peter Pinto, Maria J Merino
Background: Recent discovery of gene rearrangements have brought a new look to the molecular pathogenesis of cancer. Gene fusions occur in nearly 60% of prostate adenocarcinoma, being the TMPRSS2-ERG one of the most common. Evidence supports the role of ERG fusion in tumorigenesis, progression and invasion via effecting pathways such as WNT, MYC, uPA, PI3K/AKT/PTEN, RAS/RAF/MAPF, NKX3.1, GST-pi and androgen receptor (AR) mediated signaling. Most of the ERG fusions involve 5'-partners androgen responsive. Therefore, we aimed to evaluate AR and ERG fusion protein expression on prostate tissue to find clinicopathological applications and possible role in therapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28887080/a-rare-case-of-metastatic-extramammary-paget-disease-of-the-spine-and-review-of-the-literature
#4
A Karim Ahmed, C Rory Goodwin, Nancy Abu-Bonsrah, Doreen Nguyen, Daniel M Sciubba
Extramammary Paget disease is an intraepithelial neoplasm affecting cells rich in apocrine glands-often located in the vulvar, scrotal, or perianal region. It typically affects older patients, between the ages of 50 and 80years old, and is most often limited to the epidermis. A 47-year-old Asian male first presented with enlargement of the right inguinal lymph node. A subsequent biopsy revealed extrammamary Paget disease of the scrotum. The patient eventually developed significant worsening back pain with bilateral lower extremity numbness and weakness three months later...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885361/angioimmunoblastic-t-cell-lymphoma-and-hypereosinophilic-syndrome-with-fip1l1-pdgfra-fusion-gene-effectively-treated-with-imatinib-a-case-report
#5
Masayo Yamamoto, Katsuya Ikuta, Yasumichi Toki, Mayumi Hatayama, Motohiro Shindo, Yoshihiro Torimoto, Toshikatsu Okumura
RATIONALE: Hypereosinophilic syndrome (HES) is a rare disorder characterized by hypereosinophilia and organ damage. Some cases of HES are caused by the FIP1L1/PDGFRA fusion gene and respond to imatinib. FIP1L1/PDGFRA-positive HES occasionally evolves into chronic eosinophilic leukemia or into another form of myeloproliferative neoplasm; however, the development of a malignant lymphoma is very rare. We present a rare case of angioimmunoblastic T-cell lymphoma (AITL) and HES with the FIP1L1/PDGFRA gene rearrangement...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28875116/performance-of-robotic-assistance-for-skull-base-biopsy-a-phantom-study
#6
Jian-Hua Zhu, Jing Wang, Yong-Gui Wang, Meng Li, Yu-Xing Guo, Xiao-Jing Liu, Chuan-Bin Guo
Objectives  This study aims to evaluate the feasibility of a custom robot system guided by optical cone beam computed tomography (CBCT)-based navigation for skull base biopsy. Design  An accuracy study was conducted. Setting  Platform for navigation and robot-aided surgery technology. Participants  Phantom skull. Main Outcome Measures  The primary outcome measure was to investigate the accuracy of robot-assisted needle biopsy for skull base tumors. A 14-gauge needle was automatically inserted by the five degrees of freedom robot into the intended target, guided by optical navigation...
October 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28872226/prebiopsy-multiparametric-mri-based-risk-score-for-predicting-prostate-cancer-in-biopsy-naive-men-with-prostate-specific-antigen-between-4-10%C3%A2-ng-ml
#7
Durgesh Kumar Dwivedi, Rajeev Kumar, Alok Kumar Dwivedi, Girdhar S Bora, Sanjay Thulkar, Sanjay Sharma, Siddhartha Datta Gupta, Naranamangalam R Jagannathan
BACKGROUND: Risk calculators have traditionally utilized serum prostate-specific antigen (PSA) values in addition to clinical variables to predict the likelihood of prostate cancer (PCa). PURPOSE: To develop a prebiopsy multiparametric MRI (mpMRI)-based risk score (RS) and a statistical equation for predicting the risk of PCa in biopsy-naive men with serum PSA between 4-10 ng/mL that may help reduce unnecessary biopsies. STUDY TYPE: Prospective cross-sectional study...
September 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28871396/retrospective-comparison-of-direct-in-bore-magnetic-resonance-imaging-mri-guided-biopsy-and-fusion-guided-biopsy-in-patients-with-mri-lesions-which-are-likely-or-highly-likely-to-be-clinically-significant-prostate-cancer
#8
Wulphert Venderink, Marloes van der Leest, Annemarijke van Luijtelaar, Wendy J M van de Ven, Jurgen J Fütterer, J P Michiel Sedelaar, Henkjan J Huisman
PURPOSE: To compare clinically significant prostate cancer (csPCa) detection rates between magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) fusion-guided prostate biopsy (FGB) and direct in-bore MRI-guided biopsy (MRGB). METHODS: We performed a comparison of csPCa detection rates between FGB and MRGB. Included patients had (1) at least one prior negative TRUS biopsy; (2) a Prostate Imaging Reporting and Data System (PI-RADS) 4 or 5 lesion and (3) a lesion size of ≥8 mm measured in at least one direction...
September 4, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28866023/where-do-trus-and-mri-guided-biopsies-miss-significant-prostate-cancer
#9
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Ingegerd Balslev, Henrik S Thomsen
OBJECTIVE: To identify the location of missed sPCa lesions by transrectal ultrasound-guided (TRUSbx) and multiparametric MRI-guided biopsies (mpMRIbx) in men undergoing repeat biopsies. METHODS: 289 men with prior negative TRUSbx underwent mpMRI. The location of any suspicious lesion was registered and scored using PIRADS v1 classification according to the likelihood of being sPCa. All patients underwent repeat (re-)TRUSbx and targeted mpMRIbx (image fusion) of any suspicious lesion...
August 30, 2017: Urology
https://www.readbyqxmd.com/read/28863456/multiplex-detection-of-pediatric-low-grade-glioma-signature-fusion-transcripts-and-duplications-using-the-nanostring-ncounter-system
#10
Scott Ryall, Anthony Arnoldo, Rahul Krishnatry, Matthew Mistry, Kangzi Khor, Javal Sheth, Cino Ling, Stephie Leung, Michal Zapotocky, Ana Guerreiro Stucklin, Alvaro Lassaletta, Mary Shago, Uri Tabori, Cynthia E Hawkins
Previous studies identified recurrent fusion and duplication events in pediatric low-grade glioma (pLGG). In addition to their role in diagnosis, the presence of these events aid in dictating therapy and predicting patient survival. Clinically, BRAF alterations are most commonly identified using fluorescent in situ hybridization (FISH). However, this method is costly, labor-intensive and does not identify nonBRAF events. Here, we evaluated the NanoString nCounter gene expression system for detecting 32 of the most commonly reported fusion/duplication events in pLGG...
July 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28860428/-current-status-and-future-perspectives-of-scrum-japan
#11
Atsushi Ohtsu, Koichi Goto, Takayuki Yoshino, Wataru Okamoto, Katsuya Tsuchihara
SCRUM-Japan was launched as a nation-wide genome screening consortium for recruiting patients to 35 sponsor-/investigator- initiated registration trials in collaboration with 15 pharmaceutical companies and 240 hospitals. During the first period between February 2015 and March 2017, a total of 4,805 patients have been enrolled. Genomic profiling of each cancer were analyzed and newdrug applications of label expansion are in preparation based on the results of several registration studies including investigator-initiated trial of vandetanib for RET fusion gene positive non-small cell lung cancer...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28858541/risk-stratification-among-men-with-prostate-imaging-reporting-and-data-system-version-2-category-3-transition-zone-lesions-is-biopsy-always-necessary
#12
Ely R Felker, Steven S Raman, Daniel J Margolis, David S K Lu, Nicholas Shaheen, Shyam Natarajan, Devi Sharma, Jiaoti Huang, Fred Dorey, Leonard S Marks
OBJECTIVE: The objective of our study was to determine the clinical and MRI characteristics of clinically significant prostate cancer (PCA) (Gleason score ≥ 3 + 4) in men with Prostate Imaging Reporting and Data System Version 2 (PI-RADSv2) category 3 transition zone (TZ) lesions. MATERIALS AND METHODS: From 2014 to 2016, 865 men underwent prostate MRI and MRI/ultrasound (US) fusion biopsy (FB). A subset of 90 FB-naïve men with 96 PI-RADSv2 category 3 TZ lesions was identified...
August 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28851664/pediatric-soft-tissue-tumor-of-the-upper-arm-with-lmna-ntrk1-fusion
#13
Shinji Kohsaka, Tsuyoshi Saito, Keisuke Akaike, Yoshiyuki Suehara, Takuo Hayashi, Tatsuya Takagi, Kazuo Kaneko, Toshihide Ueno, Shinya Kojima, Ken-Ichi Kohashi, Hiroyuki Mano, Yoshinao Oda, Takashi Yao
A 6-year-old girl was admitted to our hospital due to the presence of a slow-growing tumor in her right elbow. Biopsy specimens showed a round- to spindle-cell neoplasm with uncertain malignant potential, leading to the decision of surgical resection. Histologically, the resected tumor was encapsulated by fibrous tissue, but focally invaded the surrounding skeletal muscles. The tumor was composed of ganglion-cell-like short spindle cells with lymphocytic infiltration in the collagenous background. Tumor cells with large bizarre nuclei were occasionally observed, and multinucleated giant cells were scattered at the periphery...
August 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28842510/impact-of-therapy-on-genomics-and-transcriptomics-in-high-risk-prostate-cancer-treated-with-neoadjuvant-docetaxel-and-androgen-deprivation-therapy
#14
Himisha Beltran, Alexander W Wyatt, Edmund Chedgy, Adam Donoghue, Matti Annala, Evan Warner, Kevin Beja, Michael Sigouros, Fan Mo, Ladan Fazli, Colin C Collins, James A Eastham, Michael J Morris, Mary-Ellen Taplin, Andrea Sboner, Susan Halabi, Martin E Gleave
BACKGROUND: The combination of docetaxel chemotherapy and androgen deprivation therapy (ADT) has become a standard treatment for patients with metastatic prostate cancer. The recently accrued Phase III CALGB 90203 trial was designed to investigate the clinical effectiveness of this treatment approach earlier in the disease. Specimens from this trial offer a unique opportunity to interrogate the acute molecular response to docetaxel and ADT and identify predictive biomarkers. METHODS: We evaluated baseline clinical data, needle biopsies and radical prostatectomy (RP) specimens from 52 (of 788) patients enrolled on CALGB 90203 at one high volume center...
August 25, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28842208/reclassification-rates-of-patients-eligible-for-active-surveillance-after-the-addition-of-mri-us-fusion-biopsy-an-analysis-of-seven-widely-used-eligibility-criteria
#15
Bruno Nahar, Andrew Katims, Marcelo Panizzutti Barboza, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruce Kava, Ramgopal Satyanarayana, Mark L Gonzalgo, Chad R Ritch, Dipen J Parekh, Sanoj Punnen
OBJECTIVES: To evaluate the impact of adding MRI-US fusion biopsy cores to standard 12-core biopsy in selecting men for Active Surveillance(AS). MATERIALS AND METHODS: Among men undergoing a fusion biopsy for evaluation of prostate cancer, we selected men who were eligible for at least one of seven different AS criteria based on the standard biopsy alone. We assessed each patient's eligibility for each AS criteria with and without the inclusion of fusion biopsy cores...
August 22, 2017: Urology
https://www.readbyqxmd.com/read/28838400/emergence-of-fgfr3-tacc3-fusions-as-a-potential-by-pass-resistance-mechanism-to-egfr-tyrosine-kinase-inhibitors-in-egfr-mutated-nsclc-patients
#16
Sai-Hong Ignatius Ou, Leora Horn, Marcelo Cruz, Davood Vafai, Christine M Lovly, Allison Spradlin, Michael J Williamson, Ibiayi Dagogo-Jack, Adrienne Johnson, Vincent A Miller, Shirish Gadgeel, Siraj M Ali, Alexa B Schrock
Resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) with activating EGFR mutations generally involve development of acquired secondary or tertiary EGFR mutations, such as T790M or C797S. However, case reports have demonstrated that actionable receptor tyrosine kinase fusions such as EML4-ALK, CCDC6-RET, and FGFR3-TACC3 can potentially confer resistance to EGFR TKIs. We seeked to identify the prevalence of FGFR3-TACC3 fusion transcripts as resistance mechanism to EGFR TKIs...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28838384/cell-free-circulating-tumor-dna-supplementing-tissue-biopsies-for-identification-of-targetable-mutations-implications-for-precision-medicine-and-considerations-for-reconciling-results
#17
J Kevin Hicks, James Saller, Emilie Wang, Theresa Boyle, Jhanelle E Gray
Cell-free circulating tumor DNA (ctDNA) next-generation sequencing (NGS) is emerging as a noninvasive technique for detecting targetable mutations. We describe two lung adenocarcinoma cases that show the clinical utility of supplementing tumor biopsy molecular interrogation with ctDNA NGS. For both cases, ctDNA NGS identified actionable mutations that were previously not reported by molecular interrogation of tissue. Explanations are provided for the observed differences between ctDNA and tumor biopsy genomic results along with considerations for reconciling findings...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28836968/infrarenal-high-intra-abdominal-testis-fusion-of-t2-weighted-and-diffusion-weighted-magnetic-resonance-images-and-pathological-findings
#18
Seiji Hoshi, Yuichi Sato, Junya Hata, Hidenori Akaihata, Soichiro Ogawa, Nobuhiro Haga, Yoshiyuki Kojima
BACKGROUND: Several recent reports have demonstrated that the preoperative sensitivity and accuracy of identifying and locating non-palpable testes increases with the use of conventional MRI, in addition to diffusion-weighted imaging (DWI). Therefore, pre-operative prediction of the presence and location of testes using imaging techniques may guide management of intra-abdominal testis. Fowler-Stephens orchiopexy is effective for treating patients with intra-abdominal testis; however, long-term testicular function after this procedure has not been clarified...
August 24, 2017: BMC Urology
https://www.readbyqxmd.com/read/28831094/serum-and-urine-1-h-nmr-based-metabolomics-in-the-diagnosis-of-selected-thyroid-diseases
#19
Wojciech Wojtowicz, Adam Zabek, Stanislaw Deja, Tomasz Dawiskiba, Dorota Pawelka, Mateusz Glod, Waldemar Balcerzak, Piotr Mlynarz
Early detection of nodular thyroid diseases including thyroid cancer is still primarily based on invasive procedures such as fine-needle aspiration biopsy. Therefore, there is a strong need for development of new diagnostic methods that could provide clinically useful information regarding thyroid nodular lesions in a non-invasive way. In this study we investigated (1)H NMR based metabolic profiles of paired urine and blood serum samples, that were obtained from healthy individuals and patients with nodular thyroid diseases...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28830754/focal-therapy-eligibility-determined-by-mri-us-fusion-biopsy
#20
Nima Nassiri, Edward Chang, Patricia Lieu, Alan M Priester, Daniel J A Margolis, Jiaoti Huang, Robert E Reiter, Frederick J Dorey, Leonard S Marks, Shyam Natarajan
PURPOSE: To assess focal therapy (FT) eligibility among men receiving multiparametric magnetic resonance imaging (mpMRI) and targeted biopsy, with correlation to whole mount histology after radical prostatectomy (RP). MATERIALS AND METHODS: Subjects were selected from among the 454 men (2010-2016) with targeted biopsy-proven prostate cancer (CaP) derived from regions of interest (ROI) on mpMRI. FT eligibility was limited to a maximum Gleason score (GS) of 4+3 within ROIs with or without other foci of low-risk CaP (GS 3+3, < 4 mm)...
August 19, 2017: Journal of Urology
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