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https://www.readbyqxmd.com/read/28431275/learning-non-rigid-deformations-for-robust-constrained-point-based-registration-in-image-guided-mr-trus-prostate-intervention
#1
John A Onofrey, Lawrence H Staib, Saradwata Sarkar, Rajesh Venkataraman, Cayce B Nawaf, Preston C Sprenkle, Xenophon Papademetris
Accurate and robust non-rigid registration of pre-procedure magnetic resonance (MR) imaging to intra-procedure trans-rectal ultrasound (TRUS) is critical for image-guided biopsies of prostate cancer. Prostate cancer is one of the most prevalent forms of cancer and the second leading cause of cancer-related death in men in the United States. TRUS-guided biopsy is the current clinical standard for prostate cancer diagnosis and assessment. State-of-the-art, clinical MR-TRUS image fusion relies upon semi-automated segmentations of the prostate in both the MR and the TRUS images to perform non-rigid surface-based registration of the gland...
April 12, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28423551/metabolic-reprogramming-of-the-premalignant-colonic-mucosa-is-an-early-event-in-carcinogenesis
#2
Mart Dela Cruz, Sarah Ledbetter, Sanjib Chowdhury, Ashish K Tiwari, Navneet Momi, Ramesh K Wali, Charles Bliss, Christopher Huang, David Lichtenstein, Swati Bhattacharya, Anisha Varma-Wilson, Vadim Backman, Hemant K Roy
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States. There is an increasing need for the identification of biomarkers of pre-malignant and early stage CRC to improve risk-stratification and screening recommendations. In this study, we investigated the possibility of metabolic and mitochondrial reprogramming early in the pre-malignant colorectal field. METHODS: Rectal biopsies were taken from 81 patients undergoing screening colonoscopy, and gene expression of metabolic and mitochondrial markers were assessed using real time quantitative PCR...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414318/initial-sites-of-hepadnavirus-integration-into-host-genome-in-human-hepatocytes-and-in-the-woodchuck-model-of-hepatitis-b-associated-hepatocellular-carcinoma
#3
R Chauhan, N D Churchill, P M Mulrooney-Cousins, T I Michalak
Hepatitis B virus (HBV) and the closely related woodchuck hepatitis virus (WHV) are potent carcinogens that trigger development of primary hepatocellular carcinoma (HCC). The initial sites of hepadnavirus-host genome integration, their diversity and kinetics of formation can be central to virus persistence and the initiation and progression of HCC. To recognize the nature of the very early virus-host interactions, we explored de novo infection of human hepatocyte-like HepaRG cells with authentic HBV and naive woodchucks with WHV...
April 17, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28410289/initial-experience-with-real-time-hybrid-single-photon-emission-computed-tomography-computed-tomography-guided-percutaneous-transthoracic-needle-biopsy
#4
Qian Hua, Xiangyun Zhu, Lei Zhang, Yanjun Zhao, Ping Tang, Jianming Ni
The aim of this study was to explore a technique that uses real-time fusion image of single-photon emission computed tomography/computed tomography (SPECT/CT) to guide percutaneous transthoracic needle biopsy (PTNB) and test its feasibility and safety in patients. Twelve patients with intrathoracic lesions suspicious for malignancy underwent real-time 99m-technetium sestamibi SPECT/CT-guided PTNB. Chest SPECT/CT fusion images were used for biopsy planning and intraprocedure fusion of SPECT with guiding CT was used to adjust the puncture angle and direction...
April 13, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28400169/combined-clinical-parameters-and-multiparametric-magnetic-resonance-imaging-for-advanced-risk-modeling-of-prostate-cancer-patient-tailored-risk-stratification-can-reduce-unnecessary-biopsies
#5
Jan Philipp Radtke, Manuel Wiesenfarth, Claudia Kesch, Martin T Freitag, Celine D Alt, Kamil Celik, Florian Distler, Wilfried Roth, Kathrin Wieczorek, Christian Stock, Stefan Duensing, Matthias C Roethke, Dogu Teber, Heinz-Peter Schlemmer, Markus Hohenfellner, David Bonekamp, Boris A Hadaschik
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) is gaining widespread acceptance in prostate cancer (PC) diagnosis and improves significant PC (sPC; Gleason score≥3+4) detection. Decision making based on European Randomised Study of Screening for PC (ERSPC) risk-calculator (RC) parameters may overcome prostate-specific antigen (PSA) limitations. OBJECTIVE: We added pre-biopsy mpMRI to ERSPC-RC parameters and developed risk models (RMs) to predict individual sPC risk for biopsy-naïve men and men after previous biopsy...
April 8, 2017: European Urology
https://www.readbyqxmd.com/read/28396920/the-role-of-whole-lesion-apparent-diffusion-coefficient-analysis-for-predicting-outcomes-of-prostate-cancer-patients-on-active-surveillance
#6
Tsutomu Tamada, Hasan Dani, Samir S Taneja, Andrew B Rosenkrantz
PURPOSE: To explore the role of whole-lesion apparent diffusion coefficient (ADC) analysis for predicting outcomes in prostate cancer patients on active surveillance. METHODS: This study included 72 prostate cancer patients who underwent MRI-ultrasound fusion-targeted biopsy at the initiation of active surveillance, had a visible MRI lesion in the region of tumor on biopsy, and underwent 3T baseline and follow-up MRI examinations separated by at least one year. Thirty of the patients also underwent an additional MRI-ultrasound fusion-targeted biopsy after the follow-up MRI...
April 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28396184/focal-laser-ablation-of-prostate-cancer-feasibility-of-mri-us-fusion-for-guidance
#7
Shyam Natarajan, Tonye A Jones, Alan M Priester, Rory Geoghegan, Patricia Lieu, Merdie Delfin, Ely Felker, Daniel J A Margolis, Anthony Sisk, Allan Pantuck, Warren Grundfest, Leonard S Marks
PURPOSE: Focal laser ablation (FLA) is a potential treatment for some men with prostate cancer (CaP). As currently practiced, FLA is performed by radiologists in a MRI unit (in-bore). We evaluated the safety and feasibility of performing FLA in a urology clinic (out-of-bore), using magnetic resonance imaging-ultrasound (MRI/US) fusion for guidance. MATERIALS AND METHODS: 11 men with intermediate risk CaP were enrolled in this prospective, IRB-approved pilot study...
April 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28391284/gleason-score-within-prostate-abnormal-areas-defined-by-multiparametric-magnetic-resonance-imaging-did-not-vary-according-to-the-pirads-score
#8
Hakim Slaoui, Yann Neuzillet, Tarek Ghoneim, Mathieu Rouanne, Abdelali Abdou, Pierre Marie Lugagne-Delpon, Antoine Scherrer, Camelia Radulescu, Christian Delancourt, Vincent Molinié, Thierry Lebret
BACKGROUND: We aim to correlate multiparametric magnetic resonance imaging (mpMRI) of the prostate reporting (Prostate Imaging Reporting and Data System [PI-RADS] version 2) with the Gleason score into both radical prostatectomy (RP) specimen and MRI fusion-targeted biopsies (FTB). METHODS: mpMRI of 74 patients who underwent an RP after FTB were retrospectively reviewed. The Gleason score distribution was compared according to the PI-RADS score using the Kruskal-Wallis test...
April 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28381220/the-prostate-cancer-detection-rates-of-ceus-targeted-versus-mri-targeted-versus-systematic-trus-guided-biopsies-in-biopsy-na%C3%A3-ve-men-a-prospective-comparative-clinical-trial-using-the-same-patients
#9
A W Postema, M J V Scheltema, C K Mannaerts, R J G Van Sloun, T Idzenga, M Mischi, M R E Engelbrecht, J J M C H De la Rosette, H Wijkstra
BACKGROUND: The current standard for Prostate Cancer (PCa) detection in biopsy-naïve men consists of 10-12 systematic biopsies under ultrasound guidance. This approach leads to underdiagnosis and undergrading of significant PCa while insignificant PCa may be overdiagnosed. The recent developments in MRI and Contrast Enhanced Ultrasound (CEUS) imaging have sparked an increasing interest in PCa imaging with the ultimate goal of replacing these "blind" systematic biopsies with reliable imaging-based targeted biopsies...
April 5, 2017: BMC Urology
https://www.readbyqxmd.com/read/28381148/egfr-exon-20-insertion-duplication-mutation-in-fibrous-hamartoma-of-infancy-with-predominantly-pseudoangiomatous-pattern-mimicking-giant-cell-fibroblastoma
#10
Natalie Ellington, Jason Y Park, Kathryn King, Shellie Josephs, Dinesh Rakheja
We describe a case of fibrous hamartoma of infancy (FHI) with predominant pseudoangiomatous histologic pattern that harbors a recently described characteristic molecular feature of FHI: EGFR exon 20 insertion/duplication mutation. A left axillary mass of an 8-month-old male was biopsied. Microscopic findings revealed a CD34-positive spindle cell proliferation accompanied by slit like spaces within collagen, mimicking giant cell fibroblastoma. The mass was excised. The vast majority of the mass showed histologic findings similar to the biopsy...
March 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28373135/the-value-of-psa-density-in-combination-with-pi-rads-for-the-accuracy-of-prostate-cancer-prediction
#11
Florian A Distler, Jan P Radtke, David Bonekamp, Claudia Kesch, Heinz-Peter Schlemmer, Kathrin Wieczorek, Marietta Kirchner, Sascha Pahernik, Markus Hohenfellner, Boris A Hadaschik
PURPOSE: Multiparametric MRI (mpMRI) has an emerging role in prostate cancer (PC) diagnostics. In addition, clinical information are reliable predictors for significant PC (sPC). We analyzed if the negative predictive value (NPV) of mpMRI to rule out sPC could be improved by using clinical factors, especially prostate specific antigen (PSA)-density. METHODS: 1040 consecutive men with suspicion of PC underwent mpMRI first, followed by transperineal systematic and MRI/TRUS-fusion-guided biopsy...
March 31, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28373133/prospective-evaluation-of-prostate-imaging-reporting-and-data-system-version-2-using-the-international-society-of-urological-pathology-prostate-cancer-grade-group-system
#12
Sherif Mehralivand, Sandra Bednarova, Joanna H Shih, Francesca V Mertan, Sonia Gaur, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
PURPOSE: The Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) scoring system, introduced in 2015, is based on expert consensus. In the same time; frame, a new pathologic scoring system for prostate cancer was introduced by the International Society of Urological Pathology (ISUP). Our goal was to prospectively evaluate the cancer detection rates for each PI-RADSv2 category and compare to ISUP group scores in patients undergoing systematic biopsy and MRI/transrectal ultrasound fusion-guided biopsy...
March 31, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28369879/human-skeletal-muscle-fibroblasts-stimulate-in-vitro-myogenesis-and-in-vivo-muscle-regeneration
#13
Abigail L Mackey, Mélanie Magnan, Bénédicte Chazaud, Michael Kjaer
Accumulation of skeletal muscle extracellular matrix is an unfavourable characteristic of many muscle diseases, muscle injury and sarcopenia. In addition to the indispensable role satellite cells play in muscle regeneration, there is emerging evidence in rodents for a regulatory influence on fibroblast activity. However the influence of fibroblasts on satellite cells and muscle regeneration in humans is unknown. The purpose of this study was to investigate this in vitro and during in vivo regeneration in humans...
March 30, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28368455/tracking-a-cad-alk-gene-rearrangement-in-urine-and-blood-of-a-colorectal-cancer-patient-treated-with-an-alk-inhibitor
#14
G Siravegna, A Sartore-Bianchi, B Mussolin, A Cassingena, A Amatu, L Novara, M Buscarino, G Corti, G Crisafulli, A Bartolini, F Tosi, M Erlander, F Di Nicolantonio, S Siena, A Bardelli
Background: Monitoring response and resistance to kinase inhibitors is essential to precision cancer medicine, and is usually investigated by molecular profiling of a tissue biopsy obtained at progression. However, tumor heterogeneity and tissue sampling bias limit the effectiveness of this strategy. In addition, tissue biopsies are not always feasible and are associated with risks due to the invasiveness of the procedure. To overcome these limitations, blood-based liquid biopsy analysis has proven effective to non-invasively follow tumor's clonal evolution...
March 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28367856/successful-management-of-gorham-stout-disease-in-the-cervical-spine-by-combined-conservative-and-surgical-treatments-a-case-report
#15
Satoshi Tateda, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Susumu Ohtsu, Eiji Itoi, Hiroshi Ozawa
Gorham-Stout disease (GSD) is a rare condition characterized by intraosseous proliferation of endothelial-lined vessels and progressive osteolysis. The precise etiology and pathophysiology of the disease remain poorly understood. Current therapeutic options for GSD include chemotherapy, radiotherapy, and surgical resection, but the surgical treatment of GSD is difficult, especially in the spinal lesion. The indication of wide-margined resection was limited because of anatomical features. Herein, we report a case of GSD of the cervical spine in which the lesions were successfully stabilized with combined conservative and surgical treatments...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28357575/ultrasound-guided-biopsies-of-bone-lesions-without-cortical-disruption-using-fusion-imaging-and-needle-tracking-proof-of-concept
#16
Julien Garnon, Guillaume Koch, Georgia Tsoumakidou, Jean Caudrelier, Basavaraj Chari, Roberto Luigi Cazzato, Afshin Gangi
OBJECTIVE: To assess the technical feasibility and safety of combined fusion imaging and needle tracking under ultrasound guidance to target bone lesions without cortical disruption. MATERIALS AND METHODS: Between January 2016 and March 2016, seven patients underwent US-guided biopsy of bone lesions without cortical disruption. Targeted bone lesions were measuring more than 1.5 cm with a thin cortex, a trans-osseous pathway not exceeding 2 cm and without any adjacent vulnerable structures...
March 29, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28346914/top-prospective-evaluation-of-a-volume-based-computer-assisted-method-for-transperineal-optimized-prostate-biopsy
#17
Claudia Kesch, Jan Philipp Radtke, Ionel Valentin Popeneciu, Claudia Gasch, Svenja C Dieffenbacher, Tilman Klein, Heinz-Peter Schlemmer, Kathrin Wieczorek, Pawel Zogal, Markus Hohenfellner, Georgios Sakas, Boris Alexander Hadaschik
OBJECTIVE: This study is a prospective evaluation of a volume-based, computer-assisted method for transperineal optimized prostate (TOP) biopsy. The TOP algorithm automates core planning for systematic prostate biopsies using the 3-dimensional organ contour and an alterable volume for tumors to be excluded. SUBJECTS AND METHODS: MRI-transrectal ultrasound fusion biopsy with MRI-targeted biopsies (TBs) and systematic-TOP biopsies were performed on 172 men between October 2013 and March 2014...
March 28, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28341589/comprehensive-determination-of-prostate-tumor-ets-gene-status-in-clinical-samples-using-the-clia-decipher-assay
#18
Alba Torres, Mohammed Alshalalfa, Scott A Tomlins, Nicholas Erho, Ewan A Gibb, Jijumon Chelliserry, Lony Lim, Lucia L C Lam, Sheila F Faraj, Stephania M Bezerra, Elai Davicioni, Kasra Yousefi, Ashley E Ross, George J Netto, Edward M Schaeffer, Tamara L Lotan
ETS family gene fusions are common in prostate cancer and molecularly define a tumor subset. ERG is the most commonly rearranged member, leading to its overexpression, followed by ETV1, ETV4, and ETV5, and these alterations are generally mutually exclusive. We validated the Decipher prostate cancer assay to detect ETS alterations in a Clinical Laboratory Improvement Amendments-accredited laboratory. Benchmarking against ERG immunohistochemistry and ETV1/4/5 RNA in situ hybridization, we examined the accuracy, precision, and reproducibility of gene expression ETS models using formalin-fixed, paraffin-embedded samples...
March 21, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28339163/next-generation-sequencing-of-urine-specimens-a-novel-platform-for-genomic-analysis-in-patients-with-non-muscle-invasive-urothelial-carcinoma-treated-with-bacille-calmette-gu%C3%A3-rin
#19
Sasinya N Scott, Irina Ostrovnaya, Caroline M Lin, Nancy Bouvier, Bernard H Bochner, Gopakumar Iyer, David Solit, Michael F Berger, Oscar Lin
BACKGROUND: Biopsies from patients with high-risk (HR) non-muscle-invasive urothelial carcinoma (NMIUC), especially flat urothelial carcinoma in situ, frequently contain scant diagnostic material or denuded mucosa only, and this precludes further extensive genomic analysis. This study evaluated the use of next-generation sequencing (NGS) analysis of urine cytology material from patients with HR NMIUC in an attempt to identify genetic alterations that might correlate with clinical features and responses to bacille Calmette-Guérin (BCG) treatment...
March 24, 2017: Cancer
https://www.readbyqxmd.com/read/28333017/effect-of-prostate-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-on-radiation-treatment-recommendations
#20
Aaron Reed, Luca F Valle, Uma Shankavaram, Andra Krauze, Aradhana Kaushal, Erica Schott, Theresa Cooley-Zgela, Bradford Wood, Peter Pinto, Peter Choyke, Baris Turkbey, Deborah E Citrin
PURPOSE: Targeted magnetic resonance imaging (MRI)/ultrasound fusion prostate biopsy (MRI-Bx) has recently been compared with the standard of care extended sextant ultrasound-guided prostate biopsy (SOC-Bx), with the former associated with an increased rate of detection of clinically significant prostate cancer. The present study sought to determine the influence of MRI-Bx on radiation therapy and androgen deprivation therapy (ADT) recommendations. METHODS AND MATERIALS: All patients who had received radiation treatment and had undergone SOC-Bx and MRI-Bx at our institution were included...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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