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Lymphadenectomy in urology

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https://www.readbyqxmd.com/read/29158169/potential-benefit-of-lymph-node-dissection-during-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-a-systematic-review-by-the-european-association-of-urology-guidelines-panel-on-non-muscle-invasive-bladder-cancer
#1
REVIEW
Jose Luis Dominguez-Escrig, Benoit Peyronnet, Thomas Seisen, Harman M Bruins, Cathy Yuhong Yuan, Marko Babjuk, Andreas Böhle, Maximilian Burger, Eva M Compérat, Paolo Gontero, Thomas Lam, Steven MacLennan, Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Richard J Sylvester, Richard Zigeuner, Shahrokh F Shariat, Morgan Rouprêt
CONTEXT: The oncological efficacy of routine lymphadenectomy (lymph node dissection [LND]) at the time of radical nephroureterectomy (RNU) remains controversial. OBJECTIVE: To systematically review the available literature assessing the impact of LND in upper tract urothelial carcinoma (UTUC) patients. EVIDENCE ACQUISITION: Embase, Medline, and Cochrane databases were searched for all studies comparing outcomes of patients undergoing RNU without LND versus any form of LND...
November 17, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29110272/impact-of-county-rurality-and-urologist-density-on-the-practice-of-inguinal-lymph-node-dissection-and-mortality-in-patients-diagnosed-with-squamous-cell-carcinoma-of-the-penis
#2
Michael Romanelli, Tariq Issa, Whitney Zahnd, Danuta Dynda, Shaheen Alanee
BACKGROUND: Inguinal lymphadenectomy (LND) is influential in reducing the mortality of squamous cell carcinoma of the penis (SCCP). We investigated the impact of urologic workforce density (UD) and rural residence (RR) on the practice of LND and mortality of SCCP (SCCP-RM). MATERIALS AND METHODS: UD was determined from the 2014 to 2015 Area Health Resource File data, while RR was determined using the 2003 rural-urban continuum codes. All cases of SCCP within the surveillance, epidemiology, and end results 18 registry with known county codes were used for analysis (n = 2863)...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28891799/-paratesticular-sarcoma-with-synchronous-renal-carcinoma
#3
Juan Astigueta, Milagros Abad-Licham, Lenin Fernández, Marisabel Huerta, Juan Terrones, Mariela Pow-Sang
OBJETIVE: Primary undifferentiated pleomorphic sarcoma (UPS) of the testicular tunics is rare, and synchronism with other malignancies of the urinary tract is uncommon, and may complicate the staging and therapeutic approach. We report the case of a patient diagnosed with primary paratesticular UPS with synchronous Renal Carcinoma. METHODS: Patient presenting with intrascrotal tumor who underwent left radical orchiectomy. In staging work up studies a second urologic neoplasia was found in the kidney...
September 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28865709/minilaparoscopy-in-urology-systematic-review
#4
A Pérez-Lanzac, R García-Baquero
CONTEXT: There has been a boom in recent years in urological procedures using minilaparoscopy (ML). OBJECTIVE: To conduct a systematic review of the published evidence on ML and its current role in urology. ACQUISITION OF EVIDENCE: We performed a search on MedLine spanning October 1983 to December 2016 according to PRISMA criteria. A total of 6 comparative articles and 13 series were selected for this manuscript. SUMMARY OF THE EVIDENCE: Only 1 study was randomised, 4 studies were prospective and comparative, and most were case series in which the operations were performed with 3-mm instruments...
August 30, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28813037/concomitant-bladder-cancer-and-prostate-cancer-challenges-and-controversies
#5
REVIEW
Antonio Lopez-Beltran, Liang Cheng, Francesco Montorsi, Maria Scarpelli, Maria R Raspollini, Rodolfo Montironi
Radical cystoprostatectomy (RCP) followed by bilateral pelvic lymphadenectomy and urinary diversion remains the gold-standard therapy for men with localized muscle-invasive bladder cancer (MIBC). Prostate cancer might be incidentally detected at the time of RCP with a reported prevalence of 24-51%. Typically, these patients are considered to have clinically insignificant disease, but data from emerging series challenge this assumption and suggest that some of these tumours might be aggressive, or somehow increase the aggressiveness of the associated MIBC, and can negatively influence the patient's overall survival outcomes...
October 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28753897/lack-of-effectiveness-of-postchemotherapy-lymphadenectomy-in-bladder-cancer-patients-with-clinical-evidence-of-metastatic-pelvic-or-retroperitoneal-lymph-nodes-only-a-propensity-score-based-analysis
#6
Andrea Necchi, Luigi Mariani, Salvatore Lo Vullo, Evan Y Yu, Michael E Woods, Yu-Ning Wong, Lauren C Harshman, Ajjaj Alva, Cora N Sternberg, Aristotelis Bamias, Petros Grivas, Vadim S Koshkin, Florian Roghmann, Jakub Dobruch, Bernie J Eigl, Lucia Nappi, Matthew I Milowsky, Guenter Niegisch, Sumanta K Pal, Ugo De Giorgi, Federica Recine, Ulka Vaishampayan, Dominik D Berthold, Daniel W Bowles, Jack Baniel, Christine Theodore, Sylvain Ladoire, Sandy Srinivas, Neeraj Agarwal, Simon Crabb, Srikala Sridhar, Ali-Reza Golshayan, Carsten Ohlmann, Evanguelos Xylinas, Thomas Powles, Johnathan E Rosenberg, Joaquim Bellmunt, Bas van Rhijn, Matthew D Galsky, Kees Hendricksen
BACKGROUND: Limited data is available on the role, and extent of, postchemotherapy lymphadenectomy (PC-LND) in patients with clinical evidence of pelvic (cN1-3) or retroperitoneal (RP) lymph node spread from urothelial bladder carcinoma. OBJECTIVE: To compare the outcomes of operated versus nonoperated patients after first-line chemotherapy. DESIGN, SETTING, AND PARTICIPANTS: Data from 34 centers was collected, totaling 522 patients, treated between January 2000 and June 2015...
June 3, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28728992/retroperitoneal-lymphadenectomy-in-high-risk-nonmetastatic-renal-cell-carcinoma-an-analysis-of-the-assure-ecog-acrin-2805-adjuvant-trial
#7
Benjamin T Ristau, Judi Manola, Naomi B Haas, Daniel Y C Heng, Edward M Messing, Christopher G Wood, Christopher J Kane, Robert S DiPaola, Robert G Uzzo
PURPOSE: Lymphadenectomy is a well established practice for many urological malignancies but its role in renal cell carcinoma is less clear. Our primary objective was to determine whether lymphadenectomy impacted survival in patients with fully resected, high risk renal cell carcinoma. MATERIALS AND METHODS: Patients with fully resected, high risk, nonmetastatic renal cell carcinoma were randomized to adjuvant sorafenib, sunitinib or placebo in the ASSURE (Adjuvant Sorafenib and Sunitinib for Unfavorable Renal Carcinoma) trial...
July 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28285790/diagnosis-and-treatment-for-clinically-localized-prostate-cancer-adherence-to-the-european-association-of-urology-clinical-guidelines-in-a-nationwide-population-based-study-gescap-group
#8
F Gómez-Veiga, A Rodríguez-Antolín, B Miñana, C Hernández, J F Suárez, J M Fernández-Gómez, M Unda, J Burgos, A Alcaraz, P Rodríguez, R Medina, J Castiñeiras, C Moreno, E Pedrosa, J M Cózar
OBJECTIVE: To assess the adherence to European Association of Urology (EAU) guidelines in the management of prostate cancer (PCa) in Spain. PATIENTS AND METHODS: Epidemiological, population-based, study including a national representative sample of 3,918 incident patients with histopathological confirmation during 2010; 95% of the patient's sample was followed up for at least one year. Diagnosis along with treatment related variables (for localized PCa -low, intermediate, high and locally-advanced by D'Amico risk stratification) was recorded...
March 9, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28237495/prostate-cancer-before-renal-transplantation-a-multicentre-study
#9
C Chahwan, A Doerfler, N Brichart, S Bouyé, T Culty, C Iselin, C Pfister, F Sallusto, L Salomon, G Verhoest, L Viart, X Tillou
INTRODUCTION: The surgical issues of renal transplantation (RT) after localized prostate cancer (PC) treatment and oncological outcomes after transplantation in patients on the waiting list with a history of PC were unknown. We conducted a retrospective multicentre study including all patients with PC diagnosed before the kidney transplantation. METHODS: Fifty-two patients were included from December 1993 to December 2015. The median age at diagnosis of PC was 59...
March 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28157406/biomarker-molecular-and-technologic-advances-in-urologic-pathology-oncology-and-imaging
#10
REVIEW
Carla L Ellis, Lara R Harik, Cynthia Cohen, Adeboye O Osunkoya
Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation...
April 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28009144/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal
#11
REVIEW
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#12
REVIEW
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27824248/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal-a-systematic-review
#13
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
November 8, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27605238/prognostic-factors-for-long-term-quality-of-life-after-adjuvant-radiotherapy-in-women-with-endometrial-cancer
#14
Robert Foerster, Lara Schnetzke, Thomas Bruckner, Nathalie Arians, Harald Rief, Juergen Debus, Katja Lindel
BACKGROUND: Adjuvant radiotherapy (RT) for endometrial cancer (EC) may affect patients' quality of life (QoL). There is a paucity of data on prognostic factors for long-term QoL and sexual functioning. This study aimed to investigate such factors and assess the role of the vaginal dilator (VD). METHODS: QoL was assessed in 112 EC patients 6 years (median) after RT. QoL was compared to normative data, and the influence of age, tumor characteristics, lymphadenectomy, RT, and acute toxicities was assessed...
December 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27148929/long-term-results-and-prognostic-factors-of-pulmonary-metastasectomy-in-patients-with-metastatic-transitional-cell-carcinoma
#15
MULTICENTER STUDY
Luca Luzzi, Giuseppe Marulli, Piero Solli, Giuseppe Cardillo, Marco Ghisalberti, Marco Mammana, Francesco Carleo, Lorenzo Spaggiari, Federico Rea
Objective We wanted to assess the prognostic factors and the efficacy of the treatment in patients who underwent lung resections for transitional cell carcinoma metastases. Materials and Methods This is a retrospective, multicenter study. Between January 1995 and May 2014, 69 patients underwent lung metastasectomy with curative intent. We evaluated primary site of the tumor, the role of adjuvant chemotherapy after urological operation, disease-free interval (DFI; lower or higher than 24 months), type of lung resection, number of lung metastases, presence of metastatic lymph nodes, and diameter of the metastasis (less or more than 3 cm)...
October 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27085487/loss-of-nuclear-bap1-protein-expression-is-a-marker-of-poor-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#16
Daniele Minardi, Guendalina Lucarini, Giulio Milanese, Roberto Di Primio, Rodolfo Montironi, Giovanni Muzzonigro
INTRODUCTION: BRCA1-associated protein 1 (BAP1) is a gene situated on chromosome 3p in a region that is deleted in more than 90% of renal cell carcinomas (RCCs). In the present study, we studied BAP1 immunohistochemical expression in a large series of conventional clear cell RCCs (ccRCCs) treated with radical nephrectomy; we assessed the prognostic value of their expression in terms of patients׳ survival at long-term follow-up. MATERIALS AND METHODS: A total of 154 consecutive patients with ccRCC were selected from a prospective database and considered for the study purpose; all patients were treated with radical nephrectomy and lymphadenectomy at our Institute of Urology between 1983 and 1985...
August 2016: Urologic Oncology
https://www.readbyqxmd.com/read/26664554/penile-cancer-about-ten-cases-at-the-university-hospital-of-rabat-review-of-the-literature
#17
REVIEW
Amine Slaoui, Youness Jabbour, Anouar El Ghazoui, Tarik Karmouni, Khalid Elkhader, Abdelatif Koutani, Ahmed Ibn Attaya
UNLABELLED: The aim of our study was to report the status of penile cancer sites in the urology department at the University Hospital of Rabat and evaluate long-term results of surgical treatment of this cancer. PATIENTS AND METHODS: Between 1989 and 2015, 10 patients were treated for penile cancer. 10 cases were retrospectively reviewed and the following data were recorded: mode of revelation, seat, staging, TNM stage, treatment, evolution and survival. The mean age of patients was 58,1 years (48-81 years)...
2015: Pan African Medical Journal
https://www.readbyqxmd.com/read/26237821/-bilateral-nephroureterectomy-with-cystoprostatectomy-ad-bloc-and-lymphadenectomy-in-a-patient-with-end-stage-renal-failure-and-cancer-of-the-urinary-bladder-t2bn0m0
#18
V I Vtorenko, R N Trushkin, A E Lubennikov, O L Podkorytova, P I Motin
The article introduces a clinical example of a patient who was first diagnosed with bladder cancer, which contributed to the development of end-stage renal failure. Initially, given the significant upper urinary tract retention and post renal acute renal failure, the patient underwent bilateral percutaneous nephrostomy. Taking into account periodic gross hematuria, cystoscopy and transurethral electrocoagulation and biopsy of bladder tumor were performed and bladder cancer was identified. Despite adequate functioning of nephrostome drainage and daily urine output up to 3000 ml, kidney failure was not resolved...
March 2015: Urologii︠a︡
https://www.readbyqxmd.com/read/26216819/minimally-invasive-retroperitoneal-lymphadenectomy-current-status
#19
REVIEW
Thomas Kunit, Günter Janetschek
Although the standard approach of retroperitoneal lymphadnectomy (RLA) is open surgery, laparoscopy is an emerging technique in urology and reports of laparoscopic RLA are increasing. This article presents the indications, technique, and outcome of RLA as primary treatment and post-cisplatin-based chemotherapy by means of laparoscopy. In expert hands RLA is minimally invasive and reduces morbidity in comparison with open surgery, with the same oncologic outcome. However, patient selection is crucial.
August 2015: Urologic Clinics of North America
https://www.readbyqxmd.com/read/26100328/commentary-on-racial-variation-in-the-quality-of-surgical-care-for-bladder-cancer-barocas-da-alvarez-j-koyama-t-anderson-cb-gray-dt-fowke-jh-you-c-chang-ss-cookson-ms-smith-ja-jr-penson-df-department-of-urologic-surgery-vanderbilt-university-nashville-tennessee
#20
COMMENT
Brent Hollenbeck
BACKGROUND: Differences in quality of care may contribute to racial variation in outcomes of bladder cancer (BCa). Quality indicators in patients undergoing surgery for BCa include the use of high-volume surgeons and high-volume hospitals, and, when clinically indicated, receipt of pelvic lymphadenectomy, receipt of continent urinary diversion, and undergoing radical cystectomy instead of partial cystectomy. The authors compared these quality indicators as well as adverse perioperative outcomes in black patients and white patients with BCa...
May 2016: Urologic Oncology
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