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https://www.readbyqxmd.com/read/29925629/incidence-morbidity-and-mortality-of-patients-with-achalasia-in-england-findings-from-a-study-of-nationwide-hospital-and-primary-care-data
#1
Philip R Harvey, Tom Thomas, Joht S Chandan, Jemma Mytton, Ben Coupland, Neeraj Bhala, Felicity Evison, Prashant Patel, Krishnarajah Nirantharakumar, Nigel J Trudgill
BACKGROUND: Achalasia is an uncommon condition characterised by failed lower oesophageal sphincter relaxation. Data regarding its incidence, prevalence, disease associations and long-term outcomes are very limited. METHODS: Hospital Episode Statistics (HES) include demographic and diagnostic data for all English hospital attendances. The Health Improvement Network (THIN) includes the primary care records of 4.5 million UK subjects, representative of national demographics...
June 20, 2018: Gut
https://www.readbyqxmd.com/read/29924199/pupillometry-in-chagas-disease
#2
Diva Vargas, Cleudson Castro
PURPOSE: We investigated parasympathetic innervation abnormalities of the iris sphincter and ciliary muscles in chronic Chagas disease by measuring pupillary diameter and intraocular pressure. METHODS: A group of 80 patients with Chagas disease was compared with 76 healthy individuals without chagasic infection. The following procedures were performed: pupillometry, hypersensitivity test to pilocarpine 0.125%, intraocular pressure measurement (IOP), basal pupil diameter (BPD), absolute pupillary constriction amplitude (ACA), relative pupillary constriction amplitude (RCA) and the presence of anisocoria...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29923482/comparison-of-outcomes-following-intersphincteric-resection-vs-low-anterior-resection-for-low-rectal-cancer-a-systematic-review
#3
REVIEW
P Ursi, A Santoro, A Gemini, A Arezzo, D Pironi, C Renzi, R Cirocchi, F M Di Matteo, A Maturo, V D'Andrea, J Sagar
BACKGROUND: Low Rectal Anterior Resection (LAR) is challenging when anal canal mucosa and/or internal sphincter are involved by very low tumors. In these cases, Intersphincteric resection (ISR) with the removal of the internal sphincter is designed to increase the distal margin of resection, thus preserving the external sphincter and pubo-rectalis muscle complex. Aim is to compare results after ISR with those of LAR, including subgroup analysis of open, laparoscopic and robotic ISR. METHODS: Studies published from January 1991 to January 2017 describing ISR and comparing results with LAR in adults were included irrespective of the technique...
May 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29921684/enhancing-recognition-of-obstetric-anal-sphincter-injuries-in-six-maternity-units-in-palestine-an-interventional-quality-improvement-study
#4
Hadil Ali-Masri, Sahar Hassan, Khaled Ismail, Kaled Zimmo, Mohammed Zimmo, Erik Fosse, Åse Vikanes, Katariina Laine
OBJECTIVE: To explore the impact of a training intervention on obstetric anal sphincter injuries' (OASIS) detection rate. DESIGN: Prospective quality improvement interventional study. SETTING: Six secondary and tertiary maternity units in Palestine. POPULATION: Women having singleton vaginal births ≥23 weeks' gestation or babies weighing ≥500 g (n=22 922). Caesarean births (n=5431), multiple gestations (n=443) and vaginal births of unregistered perineum status (n=800) were excluded...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29916871/a-multicenter-matched-comparison-of-transanal-and-robotic-total-mesorectal-excision-for-mid-and-low-rectal-adenocarcinoma
#5
Lawrence Lee, Borja de Lacy, Marcos Gomez Ruiz, Alexander Sender Liberman, Matthew R Albert, John R T Monson, Antonio Lacy, Seon Hahn Kim, Sam B Atallah
OBJECTIVE: To compare the quality of surgical resection of transanal total mesorectal excision (TA-TME) and robotic total mesorectal excision (R-TME). BACKGROUND: Both TA-TME and R-TME have been advocated to improve the quality of surgery for rectal cancer below 10 cm from the anal verge, but there are little data comparing TA-TME and R-TME. METHODS: Data of patients undergoing TA-TME or R-TME for rectal cancer below 10 cm from the anal verge and a sphincter-saving procedure from 5 high-volume rectal cancer referral centers between 2011 and 2017 were obtained...
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916850/sphincter-of-oddi-dysfunction-sphincter-of-oddi-dysfunction-or-discordance-what-is-the-state-of-the-art-in-2018
#6
Jong Jin Hyun, Richard A Kozarek
PURPOSE OF REVIEW: To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS: The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing that neither endoscopic retrograde cholangiopancreatography-manometry nor endoscopic sphincterotomy are appropriate for SOD type III. Pain management in the latter patients has reverted to neuromodulating agents, and recent studies have suggested a role for duloxetine and potentially acupuncture...
June 16, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29915626/novel-surgical-treatments-for-gastroesophageal-reflux-disease-systematic-review-of-magnetic-sphincter-augmentation-and-electric-stimulation-therapy
#7
REVIEW
Michal Stanak, Judit Erdos, Katharina Hawlik, Tudor Birsan
Electric stimulation therapy (EST) and magnetic sphincter augmentation (MSA) represent novel methods for the surgical treatment of gastroesophageal reflux disease (GERD). The aim of this review was to assess the effectiveness and safety of EST and magnetic sphincter augmentation device (MSAD) comapred to laparoscopic fundoplication (LF) and proton pump inhibitor therapy (in case of EST). We performed a systematic literature search without restrictions on publication dates in five electronic databases (MEDLINE, EMBASE, the Cochrane library, PubMed, and Centre for Reviews and Dissemination), complemented by hand search, search in trial registries, and documentation provided by the manufacturers...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29912853/adverse-events-and-reinterventions-following-pancreatic-endoscopic-sphincterotomy
#8
Darin L Dufault, B Joseph Elmunzer, Peter B Cotton, April Williams, Gregory A Cote
OBJECTIVES: Pancreatic endoscopic sphincterotomy (PES) is an independent risk factor for short- and long-term adverse events (AEs) of endoscopic retrograde cholangiopancreatography. We sought to measure PES-specific AEs and trends in the use of PES. METHODS: This was a retrospective cohort of consecutive patients who underwent first-time PES between June 2008 and June 2015. Indications for PES were dichotomized: (1) structural pathology (chronic pancreatitis and local complications of acute pancreatitis) and (2) suspected sphincter pathology (idiopathic recurrent acute pancreatitis and sphincter of Oddi dysfunction)...
June 16, 2018: Pancreas
https://www.readbyqxmd.com/read/29909988/pelvic-floor-laxity-a-not-so-rare-but-unrecognized-form-of-daytime-urinary-incontinence-in-peripubertal-and-adolescent-girls
#9
Stuart B Bauer, Evalynn Vasquez, Marc Cendron, May M Wakamatsu, Jeanne S Chow
INTRODUCTION: Stress urinary incontinence (SUI) is common among older multiparous females but rarely reported in active, young girls. OBJECTIVES: Our hypothesis is: physically active adolescent females develop pelvic floor laxity demonstrable on upright VCUG. Our objectives are to (1) increase awareness of SUI in young females, (2) test our hypothesis with an upright VCUG, and (3) report effectiveness of step-wise management. STUDY DESIGN: A retrospective review was performed of nulliparous girls with only SUI seen from 2000 to 2015, who were evaluated with upright voiding cystourethrography (VCUG) (bladder descent defined as ≥2 cm drop of bladder neck below pubic ramus at capacity)...
June 7, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29909745/professor-william-wayne-babcock-1872-1963-and-his-innovations-in-surgery
#10
Konstantinos Laios
Professor William Wayne Babcock (1872-1963) is considered as a leading figure of American surgery during early 20th century. He introduced many innovative surgical techniques such as Babcock operation for the treatment of varicose veins, the Babcock-Bacon operation for the treatment of cancer of the rectum and sigmoid colon preserving anal sphincters, the "soup bone" cranioplasty technique, and the nerve disassociation technique for the relief of certain forms of paralysis or parasthesia due to injury or inflammation...
June 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29907234/whose-patient-is-it-the-path-to-multidisciplinary-management-of-achalasia
#11
REVIEW
Ciro Andolfi, Gyorgy Baffy, P Marco Fisichella
In the past decade, the introduction of high-resolution manometry and the classification of achalasia into subtypes has made possible to accurately diagnose the disease and predict the response to treatment for its different subtypes. However, even to date, in an era of exponential medical progress and increased insight in disease mechanisms, treatment of patients with achalasia is still rather simplistic and mostly confined to mechanical disruption of the lower esophageal sphincter by different means. In addition, there is partial consensus on what is the best form of available treatments for patients with achalasia...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29905893/s093-pneumatic-balloon-dilation-for-palliation-of-recurrent-symptoms-of-achalasia-after-esophagomyotomy
#12
Riley D Stewart, Jeffrey Hawel, Daniel French, Drew Bethune, James Ellsmere
BACKGROUND: Achalasia is a chronic disease affecting the myenteric plexus of the esophagus and lower esophageal sphincter. Treatment is aimed at palliating symptoms to improve quality of life. Treatment options for symptom relapse after esophagomyotomy include botox injection, repeat myotomy, per-oral endoscopic myotomy, or pneumatic balloon dilation (PBD). Data demonstrating the safety and efficacy of PBD for recurrence are scarce. With a lack of published data, guidelines have suggested avoiding PBD for recurrent achalasia because of concern for a high risk of perforation...
June 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29905881/initial-experience-of-endoscopic-radiofrequency-waves-delivery-to-the-lower-esophageal-sphincter-stretta-procedure-on-symptomatic-gastroesophageal-reflux-disease-post-sleeve-gastrectomy
#13
Nesreen Khidir, Luigi Angrisani, Jowhara Al-Qahtani, Sheraz Abayazeed, Moataz Bashah
BACKGROUND: Gastroesophageal reflux disease (GERD) occurs de novo or intensifies after sleeve gastrectomy (LSG). Endoscopic radiofrequency (Stretta) is a minimally invasive, effective tool to treat GERD. However, Stretta safety and efficacy are unknown in patients with GERD after LSG. To evaluate the safety and efficacy of Stretta treatment post-LSG GERD, quality of life, and PPI dose up to 6 months. METHODS: A retrospective review of all patients' data who underwent Stretta procedure in our center...
June 15, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29904299/cholesterolosis-as-a-cause-of-acute-pancreatitis
#14
Ricardo E De Armas, Jacob M Rosenberg, Andrew Z Fenves
Acute pancreatitis is an inflammatory condition of the pancreas manifesting with abdominal pain and elevated serum levels of pancreatic enzymes. Gallstones and chronic alcohol use are the most commonly described causes. A less studied cause is cholesterolosis, gallbladder polyps that cause mechanical obstruction of the sphincter of Oddi. Here, we present the case of a 55-year-old woman who presented with acute pancreatitis and was found to have cholesterol polyps in her gallbladder with no evidence of gallstones...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903631/-evidence-of-sensory-bladder-inhibitor-reflex
#15
F Charoenwong, A Charlanes, C Chesnel, D Menoux, D Motavasseli, E Tan, F Le Breton, G Amarenco
INTRODUCTION: Need to void level depends on two parameters, bladder volume and attentional process. If it is well known that the maximum voluntary contraction of the perineal muscles may transiently inhibit the micturition reflex itself, no work demonstrates the effect of this contraction on the intensity of the need itself. METHODS: An experimental, prospective, open, monocentric study was conducted between March and April 2017. In total, 15 subjects with no neurological history or neuro-perineal disorders consulting for functional constipation were included...
June 11, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29902066/cholecystokinin-induces-esophageal-longitudinal-muscle-contraction-and-transient-lower-esophageal-sphincter-relaxation-in-healthy-humans
#16
Arash Babaei, Ravinder K Mittal
Cholecystokinin (CCK) is known to cause lower esophageal sphincter (LES) relaxation through the activation of inhibitory motor neurons. Recent studies show that the longitudinal muscle contraction (LMC) related axial stretch may play a role in the LES relaxation. The aim of our study was to determine whether the CCK induced LES relaxation and identify the characteristics of associated LMC in humans. Nine healthy volunteers (5F, 40 + 12 years) received escalating doses of CCK-octapeptide (5, 10, 20 and 40 ng/kg)...
June 14, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29899438/complications-of-antireflux-surgery
#17
REVIEW
Rena Yadlapati, Eric S Hungness, John E Pandolfino
Antireflux surgery anatomically restores the antireflux barrier and is a therapeutic option for proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease or PPI intolerance. Laparoscopic fundoplication is the standard antireflux surgery, though its popularity has declined due to concerns regarding wrap durability and adverse events. As the esophagogastric junction is an anatomically complex and dynamic area subject to mechanical stress, wraps are susceptible to disruption, herniation or slippage...
June 14, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29898669/morphology-of-the-bryozoan-cinctipora-elegans-cyclostomata-cinctiporidae-with-first-data-on-its-sexual-reproduction-and-the-cyclostome-neuro-muscular-system
#18
Thomas F Schwaha, Stephan Handschuh, Andrew N Ostrovsky, Andreas Wanninger
BACKGROUND: Cyclostome bryozoans are an ancient group of marine colonial suspension-feeders comprising approximately 700 extant species. Previous morphological studies are mainly restricted to skeletal characters whereas data on soft tissues obtained by state-of-the-art methods are still lacking. In order to contribute to issues related to cyclostome ground pattern reconstruction, we analyzed the morphology of the neuromuscular system Cinctipora elegans by means of immunocytochemical staining, confocal laser scanning microscopy, histological sections and microCT imaging...
June 14, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29890263/long-term-outcome-of-treatment-of-vertebral-body-hemangiomas-with-direct-ethanol-injection-and-short-segment-stabilization
#19
P Sarat Chandra, Pankaj Singh, Rajender K, Deepak Agarwal, Vivek Tandon, S S Kale, Chitra Sarkar
BACKGROUND: Vertebral body (VH) hemangiomas with myelopathy are difficult to manage. OBJECTIVE: To evaluate the role of intra-operative ethanol embolization, surgical decompression and instrumented short segment fusion in VH with myelopathy and long-term outcome (>24 months). METHODS: Prospective study: Symptomatic VH with cord compression with myelopathy. Excluded: pathological fractures, and/or deformity or multi-level pathologies. Surgery consisted of intra-operative bilateral pedicular absolute alcohol (<1% hydrated ethyl alcohol) injection, laminectomy and cord decompression at the level of pathology followed by a short segment instrumented fusion using pedicle screws...
June 8, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29888239/medical-therapy-of-gastroesophageal-reflux-disease-beyond-proton-pump-inhibitors-where-are-we-heading
#20
REVIEW
Herbert Koop
Proton pump inhibitors (PPI) have greatly improved the treatment of gastroesophageal reflux disease. However, recent investigations have revealed that reflux symptoms persist in a substantial number of patients. Therefore, treatment strategies beyond PPI are urgently required. One such strategy may involve more reliable acid suppression, e.g., with new acid inhibitory drugs. Furthermore, the rapid appearance of an acidic compartment in the proximal stomach after a meal, which is largely responsible for postprandial heartburn, requires a specific kind of therapy in addition to PPI which still needs to be established...
April 2018: Visceral Medicine
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