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https://www.readbyqxmd.com/read/29428460/severe-hantavirus-disease-in-children
#1
Tamara K Dzagurova, Evgeniy A Tkachenko, Aydar A Ishmukhametov, Mariya V Balovneva, Boris Klempa, Detlev H Kruger
BACKGROUND: Very recently, a novel European hantavirus, Sochi virus, has been discovered which causes severe courses of hantavirus disease with a case fatality rate of about 15 percent. OBJECTIVES: We aimed to study to which extent and with which clinical severity children were affected by Sochi virus infection. STUDY DESIGN: Sochi virus infection of patients was confirmed by molecular, serological, and epizoonotic studies. Clinical and laboratory parameters were analyzed for the age group of up to 15 years (n = 6) in comparison to all older patients (n = 56)...
January 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29423367/management-of-severe-childhood-pneumonia-by-day-care-approach-in-developing-countries
#2
Yasmin Jahan, Sm Atiqur Rahman, Abu Sayeed Chowdhury, Md Moshiur Rahman
Background: Pneumonia is a major cause of child mortality among children under 5 years, worldwide. Pneumonia infection may be caused by bacteria, viruses, or fungi in single or in both lungs. According to recent criteria developed by the World Health Organization(WHO) in September (2013), pneumonia can be classified into severe pneumonia, pneumonia and no pneumonia. Most of the deaths occur from severe pneumonia. Methods: Disease management of severe childhood pneumonia requires early identification,prompt referral and the availability of intensive quality care...
2018: Health Promotion Perspectives
https://www.readbyqxmd.com/read/29411124/malignancy-and-chemotherapy-induced-haemophagocytic-lymphohistiocytosis-in-children-and-adolescents-a-single-centre-experience-of-20%C3%A2-years
#3
Volker Strenger, Gerald Merth, Herwig Lackner, Stephan W Aberle, Harald H Kessler, Markus G Seidel, Wolfgang Schwinger, Daniela Sperl, Petra Sovinz, Anna Karastaneva, Martin Benesch, Christian Urban
Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of immune dysregulation and can be divided into primary (hereditary) and secondary forms (including malignancy-associated HLH (M-HLH)). We retrospectively analysed epidemiological, clinical, virological and laboratory data from patients with M-HLH treated at our department between 1995 and 2014. Out of 1.706 haemato-/oncologic patients treated at our department between 1995 and 2014, we identified 22 (1.29%) patients with secondary HLH (1...
February 6, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29406467/subtype-specific-clinical-presentation-medical-treatment-and-family-impact-of-influenza-in-children-one-to-five-years-of-age-treated-in-outpatient-practices-in-germany-during-three-post-pandemic-years-2013-2015
#4
Andrea Streng, Christiane Prifert, Benedikt Weissbrich, Andreas Sauerbrei, Ruprecht Schmidt-Ott, Johannes G Liese
BACKGROUND: Limited data on the influenza burden in pediatric outpatients are available, especially regarding direct comparison of the co-circulating (sub)types A(H1N1)pdm09, A(H3N2) and B. METHODS: Children 1-5 years of age, unvaccinated against influenza and presenting with febrile acute respiratory infections (ARI), were enrolled in 33 paediatric practices in Germany from 2013-2015 (January-May). Influenza was confirmed by multiplex PCR from pharyngeal swabs and (sub)typed...
February 5, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29386956/misconceptions-of-parents-about-antibiotic-use-in-upper-respiratory-tract-infections-a-survey-in-primary-schools-of-the-eastern-province-ksa
#5
Moneera M Al-Shawi, Magdy A Darwish, Moataza M Abdel Wahab, Nouf A Al-Shamlan
BACKGROUND: Misuse of antibiotics has become a global public health issue for several reasons, one of which is the rapid development of antibiotic resistance that leads to high morbidity and mortality. OBJECTIVES: The objective of this study was to study the misconceptions of parents of primary school children in Dammam, Khobar, and Dhahran about the use of antibiotics for upper respiratory tract (URT) symptoms; and also study perceptions, attitudes, and behavior toward antibiotic use and identify the factors affecting this...
January 2018: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/29377913/epidemiology-characteristics-of-human-coronaviruses-in-patients-with-respiratory-infection-symptoms-and-phylogenetic-analysis-of-hcov-oc43-during-2010-2015-in-guangzhou
#6
Su-Fen Zhang, Jiu-Ling Tuo, Xu-Bin Huang, Xun Zhu, Ding-Mei Zhang, Kai Zhou, Lei Yuan, Hong-Jiao Luo, Bo-Jian Zheng, Kwok-Yung Yuen, Meng-Feng Li, Kai-Yuan Cao, Lin Xu
Human coronavirus (HCoV) is one of the most common causes of respiratory tract infection throughout the world. To investigate the epidemiological and genetic variation of HCoV in Guangzhou, south China, we collected totally 13048 throat and nasal swab specimens from adults and children with fever and acute upper respiratory infection symptoms in Gunazhou, south China between July 2010 and June 2015, and the epidemiological features of HCoV and its species were studied. Specimens were screened for HCoV by real-time RT-PCR, and 7 other common respiratory viruses were tested simultaneously by PCR or real-time PCR...
2018: PloS One
https://www.readbyqxmd.com/read/29359844/hepatitis-a-cardiomyopathy-aplastic-anemia-and-acute-liver-failure-a-devastating-scenario
#7
Verónica Botero, Víctor H García, Ana M Aristizabal, Catalina Gomez, Paola Perez, Luis A Caicedo, Gabriel J Echeverri
INTRODUCTION: Hepatitis A virus (HAV) causes an acute infection and is usually asymptomatic in children. When clinical manifestations appear, these include choluria, jaundice, and abdominal pain. Although infrequent, extra-hepatic manifestations related to HAV have been described affecting the heart, bone marrow, blood vessels, and others. CASE: A 10-year-old boy from a rural area presented with a 15-day history of malaise, fever, and jaundice; laboratory exams were compatible with HAV Infection...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29357899/pediatric-multi-drug-resistant-tuberculosis-and-hiv-co-infection-in-a-resource-limited-setting-a-case-report
#8
Christelle Géneviève Jouego, Valirie Ndip Agbor, Juergen Noeske, Ndo Akono Manuel, Leo Njock Ayuk
BACKGROUND: Tuberculosis remains a major cause of morbidity and mortality worldwide, especially in developing countries. The diagnosis and treatment of multi-drug resistant tuberculosis (MDR-TB) in children remain a major limitation in this setting, largely due to difficulties in isolating Mycobacterium tuberculosis from pediatric specimens, management with toxic second line drugs, and practically the inexistence of contact tracing. In 2016, the World Health Organization (WHO) recommended a standardized 9-month regimen for adults and children in zones which are highly endemic for the human immunodeficiency virus (HIV)...
January 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29298247/the-effect-of-early-knowledge-of-respiratory-syncytial-virus-positivity-on-medical-decision-making-and-throughput-time-within-the-pediatric-emergency-department
#9
Jessica Schnell, Lisa Schroeder, Kelly Sinclair, Lina Patel, Denise Dowd
OBJECTIVE: The aim of this study was to evaluate whether early knowledge of respiratory syncytial virus (RSV) positivity by rapid triage-based testing protocol improved emergency department (ED) throughput time and decreased ED ancillary testing and antibiotic administration. METHODS: A retrospective cohort study was performed of ED patients aged 2 to 12 months, presenting November 1 to March 31 for the years 2008-2013. Included patients presented with fever and upper respiratory tract symptoms...
January 2, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29287070/a-diagnostic-and-epidemiologic-investigation-of-acute-febrile-illness-afi-in-kilombero-tanzania
#10
Christine Hercik, Leonard Cosmas, Ondari D Mogeni, Newton Wamola, Wanze Kohi, Victor Omballa, Melvin Ochieng, Shirley Lidechi, Juma Bonventure, Caroline Ochieng, Clayton Onyango, Barry S Fields, Sayoki Mfinanga, Joel M Montgomery
INTRODUCTION: In low-resource settings, empiric case management of febrile illness is routine as a result of limited access to laboratory diagnostics. The use of comprehensive fever syndromic surveillance, with enhanced clinical microbiology, advanced diagnostics and more robust epidemiologic investigation, could enable healthcare providers to offer a differential diagnosis of fever syndrome and more appropriate care and treatment. METHODS: We conducted a year-long exploratory study of fever syndrome among patients ≥ 1 year if age, presenting to clinical settings with an axillary temperature of ≥37...
2017: PloS One
https://www.readbyqxmd.com/read/29284320/clinical-and-virologic-effects-of-four-neuraminidase-inhibitors-in-influenza-a-virus-infected-children-aged-4-12-years-an-open-label-randomized-study-in-japan
#11
Nobuo Hirotsu, Yutaka Saisho, Takahiro Hasegawa, Takao Shishido
BACKGROUND: Neuraminidase inhibitors (NAIs) reduce influenza symptoms but clear evidence of relationships between viral titer reduction and symptom alleviation is lacking. This open-label, randomized study evaluated differences in viral dynamics between NAIs, and relationships between viral dynamics and influenza symptoms (trial registration number: UMIN000012670). METHODS: Patients (n = 123) aged 4-12 years with influenza A virus infection were randomized to intravenous peramivir, oral oseltamivir, inhaled zanamivir, or inhaled laninamivir...
December 29, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29280432/a-combined-syndromic-approach-to-examine-viral-bacterial-and-parasitic-agents-among-febrile-patients-a-pilot-study-in-kilombero-tanzania
#12
Christine Hercik, Leonard Cosmas, Ondari D Mogeni, Newton Wamola, Wanze Kohi, Eric Houpt, Jie Liu, Caroline Ochieng, Clayton Onyango, Barry Fields, Sayoki Mfinanga, Joel M Montgomery
The use of fever syndromic surveillance in sub-Saharan Africa is an effective approach to determine the prevalence of both malarial and nonmalarial infectious agents. We collected both blood and naso/oro-pharyngeal (NP/OP) swabs from consecutive consenting patients ≥ 1 year of age, with an axillary temperature ≥ 37.5°C, and symptom onset of ≤ 5 days. Specimens were analyzed using both acute febrile illness (AFI) and respiratory TaqMan array cards (TAC) for multiagent detection of 56 different bloodstream and respiratory agents...
December 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29244214/mixed-viral-infections-of-the-respiratory-tract-an-epidemiological-study-during-consecutive-winter-seasons
#13
Emmanouil Antalis, Zacharoula Oikonomopoulou, Christine Kottaridi, Athanasios Kossyvakis, Aris Spathis, Maria Magkana, Aikaterini Katsouli, Vassileios Tsagris, Vassiliki Papaevangelou, Andreas Mentis, Sotirios Tsiodras
Introduction The current study aimed to describe the molecular epidemiology of mixed respiratory viral infections during consecutive winter seasons in a tertiary care hospital. Methods Patients with symptoms of respiratory tract infection were evaluated during the 2009-2011 and 2013-15 winter seasons. A clinical microarray technique was used for viral detection. Clinical and epidemiological data were correlated with mixed viral detection and the need for hospitalization. Results In 332 out of 604 (54.4%) evaluated patients (17...
December 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29214503/epidemiology-and-clinical-characteristics-of-human-coronaviruses-oc43-229e-nl63-and-hku1-a-study-of-hospitalized-children-with-acute-respiratory-tract-infection-in-guangzhou-china
#14
Zhi-Qi Zeng, De-Hui Chen, Wei-Ping Tan, Shu-Yan Qiu, Duo Xu, Huan-Xi Liang, Mei-Xin Chen, Xiao Li, Zheng-Shi Lin, Wen-Kuan Liu, Rong Zhou
Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR)...
December 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29198212/rubella-vaccination-in-india-identifying-broad-consequences-of-vaccine-introduction-and-key-knowledge-gaps
#15
A K Winter, S Pramanik, J Lessler, M Ferrari, B T Grenfell, C J E Metcalf
Rubella virus infection typically presents as a mild illness in children; however, infection during pregnancy may cause the birth of an infant with congenital rubella syndrome (CRS). As of February 2017, India began introducing rubella-containing vaccine (RCV) into the public-sector childhood vaccination programme. Low-level RCV coverage among children over several years can result in an increase in CRS incidence by increasing the average age of infection without sufficiently reducing rubella incidence. We evaluated the impact of RCV introduction on CRS incidence across India's heterogeneous demographic and epidemiological contexts...
December 4, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29189528/incidence-and-diagnostic-evaluation-of-postoperative-fever-in-pediatric-patients-with-neuromuscular-disorders
#16
Mohamed A A Yousef, Darius Dranginis, Scott Rosenfeld
BACKGROUND: Children with neuromuscular disorders have a significant chance of developing scoliosis and/or hip dislocation during childhood and adolescence and often undergo surgical reconstruction. Because of their high rate of medical comorbidities, these patients are at higher risk of postoperative complications and are therefore often comanaged, along with orthopaedics, by pediatric medicine and critical care teams. Fever during the postoperative stay is a frequent occurrence and often prompts extensive diagnostic workup which increases the cost and burden on the health system but have unclear effects on the care of the patient...
November 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29183824/zika-virus-infection-in-travelers-returning-from-countries-with-local-transmission-guangdong-china-2016
#17
Haimei Jia, Meng Zhang, Maoyu Chen, Zhiwen Yang, Jiansen Li, Guo Huang, Dawei Guan, Xiaoli Cen, Lijie Zhang, Qiwen Feng, Jianron Yi, De Wu, Haojie Zhong, Huilai Ma, Tie Song
BACKGROUND: Zika virus (ZIKV) is a mosquito-borne virus spreading rapidly in the Americas, Africa, and Asia. No indigenous ZIKV infection had been seen in China. We monitored ZIKV infection among travelers returning to Enping county from ZIKV transmitting countries from 1 March to 10 April 2016. METHODS: We analyzed data including interviews; conducted laboratory test on blood, urine, saliva, conjunctival swab or semen specimens for evidence of ZIKV infection; evaluated household for presence of Aedes mosquitoes or larvae...
November 26, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29182793/atypical-hand-foot-and-mouth-disease-caused-by-coxsackievirus-a6-in-denmark-a-diagnostic-mimicker
#18
Hans-Henrik Horsten, Michael Kemp, Thea K Fischer, Kim H Lindahl, Anette Bygum
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Patients were referred by general practitioners and dermatologists with a variety of clinical diagnoses, including eczema herpeticum, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome...
November 28, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29180056/review-of-a-licensed-dengue-vaccine-inappropriate-subgroup-analyses-and-selective-reporting-may-cause-harm-in-mass-vaccination-programs
#19
Antonio L Dans, Leonila F Dans, Mary Ann D Lansang, Maria Asuncion A Silvestre, Gordon H Guyatt
Severe life-threatening dengue fever usually occurs when a child is infected by dengue virus a 2nd time. This is caused by a phenomenon called antibody dependent enhancement or ADE. Since dengue vaccines can mimic a first infection in seronegative children (those with no previous infection), a natural infection later in life could lead to severe disease. The possibility that dengue vaccines can cause severe dengue through ADE has led to serious concern regarding the safety of mass vaccination programs. A published meta-analysis addressed this safety issue for a new vaccine against dengue fever - Dengvaxia ™...
November 24, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29172832/the-17d-204-and-17dd-yellow-fever-vaccines-an-overview-of-major-similarities-and-subtle-differences
#20
Clarissa de Castro Ferreira, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhāes, Christiane Costa-Pereira, Cleandro Pires de Albuquerque, Luciana Feitosa Muniz, Talita Yokoy de Souza, Ana Cristina Vanderley Oliveira, Olindo Assis Martins-Filho, Licia Maria Henrique da Mota
The yellow fever vaccine is a live attenuated virus vaccine that is considered one of the most efficient vaccines produced to date. The original 17D strain generated the substrains 17D-204 and 17DD, which are used for the current production of vaccines against yellow fever. The 17D-204 and 17DD substrains present subtle differences in their nucleotide compositions, which can potentially lead to variations in immunogenicity and reactogenicity. We will address the main changes in the immune responses induced by the 17D-204 and 17DD yellow fever vaccines and report similarities and differences between these vaccines in cellular and humoral immunity ...
January 2018: Expert Review of Vaccines
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