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rhinovirus infections in Children

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https://www.readbyqxmd.com/read/29350877/effects-of-human-rhinovirus-on-epithelial-barrier-integrity-and-function-in-children-with-asthma
#1
Kevin Looi, Alysia G Buckley, Paul J Rigby, Luke W Garratt, Thomas Iosifidis, Graeme R Zosky, Alexander N Larcombe, Francis J Lannigan, Kak-Ming Ling, Kelly M Martinovich, Elizabeth Kicic-Starcevich, Nicole C Shaw, Erika N Sutanto, Darryl A Knight, Anthony Kicic, Stephen M Stick
BACKGROUND: Bronchial epithelial tight junctions (TJ) have been extensively assessed in healthy airway epithelium. However, no studies have yet assessed the effect of human rhinovirus (HRV) infection on the expression and resultant barrier function in epithelial tight junctions (TJ) in childhood asthma. OBJECTIVES: To investigate the impact of HRV infection on airway epithelial TJ expression and barrier function in airway epithelial cells (AEC) of children with and without asthma...
January 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350142/lethal-respiratory-disease-associated-with-human-rhinovirus%C3%A2-c-in-wild-chimpanzees-uganda-2013
#2
Erik J Scully, Sarmi Basnet, Richard W Wrangham, Martin N Muller, Emily Otali, David Hyeroba, Kristine A Grindle, Tressa E Pappas, Melissa Emery Thompson, Zarin Machanda, Kelly E Watters, Ann C Palmenberg, James E Gern, Tony L Goldberg
We describe a lethal respiratory outbreak among wild chimpanzees in Uganda in 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples from an infant chimpanzee yielded near-complete genome sequences throughout the respiratory tract; other pathogens were absent. Epidemiologic modeling estimated the basic reproductive number (R0) for the epidemic as 1.83, consistent with the common cold in humans. Genotyping of 41 chimpanzees and examination of 24 published chimpanzee genomes from subspecies across Africa showed universal homozygosity for the cadherin-related family member 3 CDHR3-Y529 allele, which increases risk for rhinovirus C infection and asthma in human children...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29332209/the-rapid-diagnosis-of-viral-respiratory-tract-infections-and-its-impact-on-antimicrobial-stewardship-programs
#3
Şiran Keske, Önder Ergönül, Faik Tutucu, Doruk Karaaslan, Erhan Palaoğlu, Füsun Can
We aimed to describe the potential benefit of new rapid molecular respiratory tests (MRT) in decreasing inappropriate antibiotic use among the inpatients presenting with influenza-like illness (ILI). We included patients from inpatient and outpatient departments who had ILI and performed MRT between 1 January 2015 and 31 December 2016 in a 265-bed private hospital in Istanbul. At the end of 2015, we implemented antimicrobial stewardship including systematic use of MRT. Then, we compared our observations between the year 2015 and the year 2016...
January 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29331160/reduction-in-rate-of-nosocomial-respiratory-virus-infections-in-a-children-s-hospital-associated-with-enhanced-isolation-precautions
#4
Lorry G Rubin, Nina Kohn, Susan Nullet, Margaret Hill
OBJECTIVE To determine whether the use of enhanced isolation precautions (droplet and contact precautions) for inpatients with respiratory tract viral infections is associated with a reduction in rate of nosocomial viral respiratory infections. DESIGN Quasi-experimental study with the rate of nosocomial respiratory virus infection as the primary dependent variable and rate of nosocomial Clostridium difficile infection as a nonequivalent dependent variable comparator. SETTING Cohen Children's Medical Center of NY, a tertiary-care children's hospital attached to a large general hospital...
January 14, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29328393/paediatric-virology-and-its-interaction-between-basic-science-and-clinical-practice-review
#5
Ioannis N Mammas, Anne Greenough, Maria Theodoridou, Anna Kramvis, Maria Rusan, Angeliki Melidou, Paraskevi Korovessi, Georgia Papaioannou, Alexia Papatheodoropoulou, Chryssie Koutsaftiki, Maria Liston, George Sourvinos, Demetrios A Spandidos
The 3rd Workshop on Paediatric Virology, which took place on October 7th, 2017 in Athens, Greece, highlighted the role of breast feeding in the prevention of viral infections during the first years of life. Moreover, it focused on the long-term outcomes of respiratory syncytial virus and rhinovirus infections in prematurely born infants and emphasised the necessity for the development of relevant preventative strategies. Other topics that were covered included the vaccination policy in relation to the migration crisis, mother‑to‑child transmission of hepatitis B and C viruses, vaccination against human papilloma viruses in boys and advances on intranasal live‑attenuated vaccination against influenza...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29327237/regional-age-and-respiratory-secretion-specific-prevalence-of-respiratory-viruses-associated-with-asthma-exacerbation-a-literature-review
#6
REVIEW
Xue-Yan Zheng, Yan-Jun Xu, Wei-Jie Guan, Li-Feng Lin
Despite increased understanding of how viral infection is involved in asthma exacerbations, it is less clear which viruses are involved and to what extent they contribute to asthma exacerbations. Here, we sought to determine the prevalence of different respiratory viruses during asthma exacerbations. Systematic computerized searches of the literature up to June 2017 without language limitation were performed. The primary focus was on the prevalence of respiratory viruses, including AdV (adenovirus), BoV (bocavirus), CoV (coronavirus), CMV (cytomegalovirus), EnV (enterovirus), HSV (herpes simplex virus), IfV (influenza virus), MpV (metapneumovirus), PiV (parainfluenzavirus), RV (rhinovirus) and RSV (respiratory syncytial virus) during asthma exacerbations...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29314779/respiratory-viral-infections-in-infancy-and-school-age-respiratory-outcomes-and-healthcare-costs
#7
Victoria MacBean, Simon B Drysdale, Muska N Yarzi, Janet L Peacock, Gerrard F Rafferty, Anne Greenough
OBJECTIVES: To determine the impact of viral lower respiratory tract infections (LRTIs) in infancy including rhinovirus (RV) and infancy respiratory syncytial virus (RSV), on school age pulmonary function and healthcare utilization in prematurely born children. WORKING HYPOTHESIS: School age respiratory outcomes would be worse and healthcare utilization greater in children who had viral LRTIs in infancy. STUDY DESIGN: Prospective study. SUBJECT SELECTION: A cohort of prematurely born children who had symptomatic LRTIs during infancy documented, was recalled...
January 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29314338/reduced-cdhr3-expression-in-children-wheezing-with-rhinovirus
#8
Katarina Stenberg Hammar, Katarzyna Niespodziana, Marianne van Hage, Juha Kere, Rudolf Valenta, Gunilla Hedlin, Cilla Söderhäll
BACKGROUND: Rhinovirus induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin related family member 3 (CDHR3) was identified as the RV-C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced RV-C binding and increased replication in vitro. The aim of this study was to examine rs6967330 genotypes and mRNA expression of CDHR3 in relation to presence of rhinovirus and clinical symptoms in children with acute wheezing and compare to a group of age-matched healthy children...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29287070/a-diagnostic-and-epidemiologic-investigation-of-acute-febrile-illness-afi-in-kilombero-tanzania
#9
Christine Hercik, Leonard Cosmas, Ondari D Mogeni, Newton Wamola, Wanze Kohi, Victor Omballa, Melvin Ochieng, Shirley Lidechi, Juma Bonventure, Caroline Ochieng, Clayton Onyango, Barry S Fields, Sayoki Mfinanga, Joel M Montgomery
INTRODUCTION: In low-resource settings, empiric case management of febrile illness is routine as a result of limited access to laboratory diagnostics. The use of comprehensive fever syndromic surveillance, with enhanced clinical microbiology, advanced diagnostics and more robust epidemiologic investigation, could enable healthcare providers to offer a differential diagnosis of fever syndrome and more appropriate care and treatment. METHODS: We conducted a year-long exploratory study of fever syndrome among patients ≥ 1 year if age, presenting to clinical settings with an axillary temperature of ≥37...
2017: PloS One
https://www.readbyqxmd.com/read/29247051/viruses-causing-lower-respiratory-symptoms-in-young-children-findings-from-the-orchid-birth-cohort
#10
Mohinder Sarna, Stephen B Lambert, Theo P Sloots, David M Whiley, Asma Alsaleh, Lebogang Mhango, Seweryn Bialasiewicz, David Wang, Michael D Nissen, Keith Grimwood, Robert S Ware
INTRODUCTION: Viral acute respiratory infections (ARIs) cause substantial child morbidity. Sensitive molecular-based assays aid virus detection, but the clinical significance of positive tests remains uncertain as some viruses may be found in both acutely ill and healthy children. We describe disease-pathogen associations of respiratory viruses and quantify virus-specific attributable risk of ARIs in healthy children during the first 2 years of life. METHODS: One hundred fifty-eight term newborn babies in Brisbane, Australia, were recruited progressively into a longitudinal, community-based, birth cohort study conducted between September 2010 and October 2014...
December 15, 2017: Thorax
https://www.readbyqxmd.com/read/29246347/temporal-association-between-rhinovirus-activity-and-kingella-kingae-osteoarticular-infections
#11
Nina Droz, Vincent Enouf, Philippe Bidet, Damir Mohamed, Sylvie Behillil, Anne-Laure Simon, Manon Bachy, Marion Caseris, Stéphane Bonacorsi, Romain Basmaci
OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29206851/role-of-viral-coinfections-in-asthma-development
#12
Maria Luz Garcia-Garcia, Cristina Calvo, Sara Ruiz, Francisco Pozo, Victoria Del Pozo, Laura Remedios, Nadia Exposito, Ana Tellez, Inmaculada Casas
BACKGROUND: Viral respiratory infections, especially acute bronchiolitis, play a key role in the development of asthma in childhood. However, most studies have focused on respiratory syncytial virus or rhinovirus infections and none of them have compared the long-term evolution of single versus double or multiple viral infections. OBJECTIVE: Our aim was to compare the frequency of asthma development at 6-8 years in children with previous admission for bronchiolitis associated with single versus double or multiple viral infection...
2017: PloS One
https://www.readbyqxmd.com/read/29189674/concurrent-community-transmission-of-enterovirus-d68-with-human-rhinoviruses-and-respiratory-syncytial-virus-among-children-in-sendai-japan
#13
Takaya Metoki, Michiko Okamoto, Akira Suzuki, Setsuko Kitaoka, Hiroki Miyabayashi, Yuka Rokugo, Ryoichi Onuma, Suguru Ohmiya, Ko Sato, Hidekazu Nishimura, Hitoshi Oshitani, Satoru Kumaki, Rie Noguchi, Taiki Sato, Yohei Watanabe
BACKGROUND: In the autumn of 2015, we experienced a surge in the number of pediatric cases of wheeze in our hospital, which was suspected to be caused by enterovirus (EV)-D68 transmission in the community. Thus, we implemented an ad hoc retrospective surveillance for EV-D68. METHODS: Patients aged < 15 years old with acute respiratory infection were eligible for inclusion in this study. All enrolled patients underwent virus detection test. Additionally, neutralization tests (NTs) were performed using the stored serum samples of the enrolled patients to compare the antigenicity of the virus isolated in this study with that isolated in 2010 and evaluate the anti-EV-D68 antibody prevalence...
November 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29189528/incidence-and-diagnostic-evaluation-of-postoperative-fever-in-pediatric-patients-with-neuromuscular-disorders
#14
Mohamed A A Yousef, Darius Dranginis, Scott Rosenfeld
BACKGROUND: Children with neuromuscular disorders have a significant chance of developing scoliosis and/or hip dislocation during childhood and adolescence and often undergo surgical reconstruction. Because of their high rate of medical comorbidities, these patients are at higher risk of postoperative complications and are therefore often comanaged, along with orthopaedics, by pediatric medicine and critical care teams. Fever during the postoperative stay is a frequent occurrence and often prompts extensive diagnostic workup which increases the cost and burden on the health system but have unclear effects on the care of the patient...
November 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29153065/-genotypes-of-rhinoviruses-in-children-and-adults-patients-with-acute-respiratory-tract-infections
#15
Eda Demirkan, Sevin Kırdar, Emel Ceylan, Ayşe Yenigün, İmran Kurt Ömürlü
Rhinovirus (RV) is one of the most frequent causative agent of acute respiratory tract infections in the world. The virus may cause a mild cold, as well as more serious clinical symptoms in patients with immune system deficiency or comorbidities. Rhinoviruses have been identified by molecular methods under three types: RV-A, RV-B and RV-C. In most of the cases, it was reported that RV-A and RV-C were related with lower respiratory tract infections and asthma exacerbations, while RV-B was rarely reported in lower respiratory tract infections...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#16
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29143374/asthma-and-lung-function-in-adulthood-after-a-viral-wheezing-episode-in-early-childhood
#17
K Backman, H Ollikainen, E Piippo-Savolainen, K Nuolivirta, M Korppi
BACKGROUND: Viral aetiology of infection has a significant role in the long-term outcome of early-childhood wheezing. OBJECTIVE: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV). METHODS: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland)...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29131066/human-polyomavirus-wu-in-patients-with-respiratory-tract-infection-in-kuwait
#18
Sahar Essa, Wassim Chehadeh, Widad Al-Nakib
OBJECTIVE: To determine the circulating polyomavirus Washington University (WUV) strains among hospitalized patients with respiratory tract infections (RTI) in Kuwait. MATERIALS AND METHODS: Samples from 459 hospitalized children and adult patients with respiratory tract infections were screened for respiratory viruses by Polymerase chain reaction (PCR) techniques from April 2013 to April 2016. The VP2 gene from WUV-positive samples was sequenced and subjected to phylogenetic analysis...
November 7, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29124902/t-cell-responses-against-rhinovirus-species-a-and-c-in-asthmatic-and-healthy-children
#19
Cibele M Gaido, Caitlyn Granland, Ingrid A Laing, Peter N Le Souëf, Wayne R Thomas, Andrew J Currie, Belinda J Hales
BACKGROUND: Infections by rhinovirus (RV) species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other acute and chronic respiratory diseases. Infections by both species are prevalent in pre-school and school-aged children and, particularly for RV-C, can cause severe symptoms and a need for hospitalization. While associations between RV infection and asthma are well established, the adaptive immune-mechanisms by which RV infections influence asthma exacerbations are yet to be defined...
November 10, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29121479/cdhr3-genetics-and-rhinovirus-c-respiratory-illnesses
#20
Klaus Bønnelykke, Amaziah T Coleman, Michael D Evans, Jonathan Thorsen, Johannes Waage, Nadja H Vissing, Christian J Carlsson, Jakob Stokholm, Bo L Chawes, Leon E Jessen, Thea K Fischer, Yury A Bochkov, Carole Ober, Robert F Lemanske, Daniel J Jackson, James E Gern, Hans Bisgaard
Background Experimental evidence suggests that CDHR3 is a receptor for rhinovirus-C (RV-C), and a missense variant in this gene (rs6967330) is associated with childhood asthma with severe exacerbations. Objective To determine whether rs6967330 influences RV-C infections and illnesses in early childhood. Methods We studied associations between rs6967330 and respiratory infections and illnesses in the COPSAC2010 and COAST birth cohorts, where respiratory infections were monitored prospectively for the first 3 years of life...
November 9, 2017: American Journal of Respiratory and Critical Care Medicine
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