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rhinovirus infections in Children

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https://www.readbyqxmd.com/read/28526018/infection-mediated-asthma-etiology-mechanisms-and-treatment-options-with-focus-on-chlamydia-pneumoniae-and-macrolides
#1
REVIEW
Wilmore C Webley, David L Hahn
Asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. The worldwide incidence of asthma has increased dramatically in the last 40 years. According to World Health Organization (WHO) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. It is now well accepted that asthma is a heterogeneous syndrome and many clinical subtypes have been described...
May 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28521212/ado-surveillance-for-enterovirus-d68-in-colorado-children-reveals-continued-circulation
#2
Kevin Messacar, Christine C Robinson, Kristin Pretty, Ji Yuan, Samuel R Dominguez
BACKGROUND: The largest, most widespread outbreak of enterovirus D68 respiratory disease occurred from August to December of 2014 in the United States with 1153 confirmed infections in 49 states. The epidemiology of enterovirus D68 following the 2014 outbreak is unknown. OBJECTIVES: This study seeks to describe the epidemiology of enterovirus D68 circulation amongst Colorado children from 2014 to 2016. STUDY DESIGN: This is a prospective observational surveillance study of enterovirus D68 infection amongst children tested for respiratory pathogens from July-October 2014-2016 at Children's Hospital Colorado (CHCO), a quaternary care children's hospital in Aurora, CO...
May 11, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28500687/epidemiological-analysis-and-follow-up-of-human-rhinovirus-infection-in-children-with-asthma-exacerbation
#3
Shou-Yan Zheng, Li-Li Wang, Luo Ren, Jian Luo, Wei Liao, En-Mei Liu
To determine the prevalence of human rhinovirus (HRV) infection in children with acute asthma exacerbations, investigation of HRV viral load and severity of asthma exacerbations is also required. Nasopharyngeal aspirates and swabs were collected and assessed for respiratory viruses. HRV-positive samples were sequenced to identify types and determine viral load. Outpatients with asthma exacerbations underwent follow-up evaluations, their swabs were collected and clinical outcomes were recorded at their next clinic visit 4 weeks later...
May 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28489454/acquisition-and-transmission-of-streptococcus-pneumoniae-is-facilitated-during-rhinovirus-infection-in-families-with-children
#4
Sinikka Karppinen, Johanna Teräsjärvi, Kari Auranen, Linnea Schuez-Havupalo, Lotta Siira, Qiushui He, Matti Waris, Ville Peltola
RATIONALE: Laboratory and clinical evidence suggests synergy between rhinoviruses and Streptococcus pneumoniae in the pathogenesis of respiratory tract infections. However, it is unclear whether rhinoviruses promote pneumococcal acquisition and transmission. OBJECTIVES: To describe the impact of rhinovirus infection on acquisition and transmission of pneumococci within families with children. METHODS: We investigated 29 families with at least two children...
May 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28474624/viruses-causing-severe-acute-respiratory-infections-sari-in-children-%C3%A2-5-years-of-age-at-a-tertiary-care-hospital-in-rajasthan-india
#5
Bharti Malhotra, M Anjaneya Swamy, P V Janardhan Reddy, M L Gupta
BACKGROUND & OBJECTIVES: Severe acute respiratory infection (SARI) is one of the leading causes of death among children worldwide. As different respiratory viruses exhibit similar symptoms, simultaneous detection of these viruses in a single reaction mixture can save time and cost. The present study was done in a tertiary care children's hospital for rapid identification of viruses causing SARI among children less than or equal to five years of age using multiplex real-time reverse transcription polymerase chain reaction (RT-PCR) kit...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28472984/rhinovirus-c-targets-ciliated-airway-epithelial-cells
#6
Theodor F Griggs, Yury A Bochkov, Sarmila Basnet, Thomas R Pasic, Rebecca A Brockman-Schneider, Ann C Palmenberg, James E Gern
BACKGROUND: The Rhinovirus C (RV-C), first identified in 2006, produce high symptom burdens in children and asthmatics, however, their primary target host cell in the airways remains unknown. Our primary hypotheses were that RV-C target ciliated airway epithelial cells (AECs), and that cell specificity is determined by restricted and high expression of the only known RV-C cell-entry factor, cadherin related family member 3 (CDHR3). METHODS: RV-C15 (C15) infection in differentiated human bronchial epithelial cell (HBEC) cultures was assessed using immunofluorescent and time-lapse epifluorescent imaging...
May 4, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28467515/prevalence-of-non-influenza-respiratory-viruses-in-acute-respiratory-infection-cases-in-mexico
#7
Larissa Fernandes-Matano, Irma Eloísa Monroy-Muñoz, Javier Angeles-Martínez, Brenda Sarquiz-Martinez, Iliana Donají Palomec-Nava, Hector Daniel Pardavé-Alejandre, Andrea Santos Coy-Arechavaleta, Clara Esperanza Santacruz-Tinoco, Joaquín González-Ibarra, Cesar Raúl González-Bonilla, José Esteban Muñoz-Medina
BACKGROUND: Acute respiratory infections are the leading cause of morbidity and mortality worldwide. Although a viral aetiological agent is estimated to be involved in up to 80% of cases, the majority of these agents have never been specifically identified. Since 2009, diagnostic and surveillance efforts for influenza virus have been applied worldwide. However, insufficient epidemiological information is available for the many other respiratory viruses that can cause Acute respiratory infections...
2017: PloS One
https://www.readbyqxmd.com/read/28424887/a-metagenomics-study-for-the-identification-of-respiratory-viruses-in-mixed-clinical-specimens-an-application-of-the-iterative-mapping-approach
#8
Yu-Nong Gong, Shu-Li Yang, Guang-Wu Chen, Yu-Wen Chen, Yhu-Chering Huang, Hsiao-Chen Ning, Kuo-Chien Tsao
Metagenomic approaches to detect viral genomes and variants in clinical samples have various challenges, including low viral titers and bacterial and human genome contamination. To address these limitations, we examined a next-generation sequencing (NGS) and iterative mapping approach for virus detection in clinical samples. We analyzed 40 clinical specimens from hospitalized children diagnosed with acute bronchiolitis, croup, or respiratory tract infections in which virus identification by viral culture or polymerase chain reaction (PCR) was unsuccessful...
April 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28418771/persistence-in-temporary-lung-niches-a-survival-strategy-of-lung-resident-memory-cd8-t-cells
#9
Shiki Takamura
Respiratory virus infections, such as those mediated by influenza virus, parainfluenza virus, respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus (SARS-CoV), rhinovirus, and adenovirus, are responsible for substantial morbidity and mortality, especially in children and older adults. Furthermore, the potential emergence of highly pathogenic strains of influenza virus poses a significant public health threat. Thus, the development of vaccines capable of eliciting long-lasting protective immunity to those pathogens is a major public health priority...
April 18, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28411509/direct-acting-antivirals-and-host-targeting-strategies-to-combat-enterovirus-infections
#10
REVIEW
Lisa Bauer, Heyrhyoung Lyoo, Hilde M van der Schaar, Jeroen Rpm Strating, Frank Jm van Kuppeveld
Enteroviruses (e.g., poliovirus, enterovirus-A71, coxsackievirus, enterovirus-D68, rhinovirus) include many human pathogens causative of various mild and more severe diseases, especially in young children. Unfortunately, antiviral drugs to treat enterovirus infections have not been approved yet. Over the past decades, several direct-acting inhibitors have been developed, including capsid binders, which block virus entry, and inhibitors of viral enzymes required for genome replication. Capsid binders and protease inhibitors have been clinically evaluated, but failed due to limited efficacy or toxicity issues...
April 12, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28403045/polymorphisms-of-mannose-binding-lectin-and-toll-like-receptors-2-3-4-7-and-8-and-the-risk-of-respiratory-infections-and-acute-otitis-media-in-children
#11
Laura Toivonen, Juho Vuononvirta, Jussi Mertsola, Matti Waris, Qiushui He, Ville Peltola
BACKGROUND: Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are important components of the innate immune system. We assessed the susceptibility of children with genetic variants in these factors to respiratory infections, rhinovirus infections and acute otitis media. METHODS: In a prospective cohort study, blood samples from 381 Finnish children were analyzed for polymorphisms in MBL2 at codons 52, 54 and 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly, TLR7 Gln11Leu and TLR8 Leu651Leu...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28395629/a-clinical-companion-to-the-nice-guide-on-bronchiolitis
#12
Eleanor Rogers, Karen Greaves, Siba Prosad Paul
The National Institute for Health and Care Excellence (NICE) ( 2015 ) defines bronchiolitis as a lower respiratory tract infection affecting children under two years, peaking between three and six months. It affects about one in three infants in the first year of life, making it the most common respiratory infection in infants ( NICE 2015 , 2016 ). Of these infants, 2-3% will require admission to hospital ( NICE 2016 ). Respiratory syncytial virus (RSV) is the most common organism detected in the nasopharyngeal aspirate in hospitalised infants, although other viruses such as rhinovirus, parainfluenza virus, influenza virus, adenovirus and human metapneumovirus are increasingly being recognised ( Paul et al 2016 )...
April 11, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28368491/viral-pathogen-detection-by-metagenomics-and-pan-viral-group-pcr-in-children-with-pneumonia-lacking-identifiable-etiology
#13
Robert Schlaberg, Krista Queen, Keith Simmon, Keith Tardif, Chris Stockmann, Steven Flygare, Brett Kennedy, Karl Voelkerding, Anna Bramley, Jing Zhang, Karen Eilbeck, Mark Yandell, Seema Jain, Andrew T Pavia, Suxiang Tong, Krow Ampofo
Background: Community-acquired pneumonia (CAP) is a leading cause of pediatric hospitalization. Pathogen identification fails in ~20% of children but is critical for optimal treatment and prevention of hospital-acquired infections. We used two broad-spectrum detection strategies to identify pathogens in test-negative children with CAP and asymptomatic controls. Methods: Nasopharyngeal/oropharyngeal (NP/OP) swabs from 70 children <5 years with CAP of unknown etiology and 90 asymptomatic controls were tested by next-generation sequencing (RNA-seq) and pan viral group (PVG) PCR for 19 viral families...
March 25, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28368456/interference-between-respiratory-syncytial-virus-and-human-rhinovirus-infection-in-infancy
#14
Niek B Achten, Pingsheng Wu, Louis Bont, Maarten O Blanken, Tebeb Gebretsadik, James D Chappell, Li Wang, Chang Yu, Emma K Larkin, Kecia N Carroll, Larry J Anderson, Martin L Moore, Chantel D Sloan, Tina V Hartert
Background: Respiratory syncytial virus (RSV) and human rhinovirus (HRV) are the most common viruses associated with acute respiratory tract infections in infancy. Viral interference is important in understanding respiratory viral circulation and the impact of vaccines. Methods: To study viral interference, we evaluated cases of RSV and HRV codetection by polymerase chain reaction in 2 prospective birth cohort studies (the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure [INSPIRE] study and the Tennessee Children's Respiratory Initiative [TCRI]) and a double-blinded, randomized, controlled trial (MAKI), using adjusted multivariable regression analyses...
April 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28367882/severe-acute-respiratory-infection-sari-surveillance-for-hospitalized-patients-in-northern-vietnam-2011-2014
#15
Hang Khanh Le Nguyen, Son Vu Nguyen, Anh Phuong Nguyen, Phuong Mai Vu Hoang, Thanh Thi Le, Thach Co Nguyen, Huong Thu Hoang, Cuong Duc Vuong, Loan Thi Thanh Tran, Le Quynh Mai
Worldwide Severe Acute Respiratory Infections (SARI) are leading causes of hospitalization, morbidity and mortality in children. The aim of this study was to identify viral pathogens responsible for SARI in northern Vietnam from 2011 to 2014. METHODS: Throat swabs and tracheal aspirates were collected from SARI patients according to WHO Guidelines. Thirteen different viral pathogens (Influenza A(H1N)pdm09; A/H3N2; A/H5; A/H7 and B; Para influenza 1,2,3; RSV; HMPV; Adeno; SARS-CoV and Rhino) were tested by conventional/ real-time RT-PCR...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28356234/efficacy-of-novel-antibody-based-drugs-against-rhinovirus-infection-in%C3%A2-vitro-and-in%C3%A2-vivo-results
#16
Nataliia V Petrova, Alexandra G Emelyanova, Evgeniy A Gorbunov, Michael R Edwards, Ross P Walton, Nathan W Bartlett, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Musa R Khaitov, Sebastian L Johnston, Sergey A Tarasov, Oleg I Epstein
Rhinoviruses (RVs) cause the common cold and are associated with exacerbations of chronic inflammatory respiratory diseases, especially asthma and chronic obstructive pulmonary disease (COPD). We have assessed the antiviral drugs Anaferon for Children (AC) and Ergoferon (containing AC as one of the active pharmaceutical ingredients) in in vitro and in vivo experimental models, in order to evaluate their anti-rhinoviral and immunomodulatory potential. HeLa cells were pretreated with AC, and levels of the interferon-stimulated gene (ISG), 2'-5'-oligoadenylate synthetase 1 (OAS1-A) and viral replication were analyzed...
June 2017: Antiviral Research
https://www.readbyqxmd.com/read/28348590/patterns-of-human-respiratory-viruses-and-lack-of-mers-coronavirus-in-patients-with-acute-upper-respiratory-tract-infections-in-southwestern-province-of-saudi-arabia
#17
Ahmed A Abdulhaq, Vinod Kumar Basode, Anwar M Hashem, Ahmed S Alshrari, Nassrin A Badroon, Ahmed M Hassan, Tagreed L Alsubhi, Yahia Solan, Saleh Ejeeli, Esam I Azhar
We undertook enhanced surveillance of those presenting with respiratory symptoms at five healthcare centers by testing all symptomatic outpatients between November 2013 and January 2014 (winter time). Nasal swabs were collected from 182 patients and screened for MERS-CoV as well as other respiratory viruses using RT-PCR and multiplex microarray. A total of 75 (41.2%) of these patients had positive viral infection. MERS-CoV was not detected in any of the samples. Human rhinovirus (hRV) was the most detected pathogen (40...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28346512/bacterial-and-viral-pathogen-spectra-of-acute-respiratory-infections-in-under-5-children-in-hospital-settings-in-dhaka-city
#18
Golam Sarower Bhuyan, Mohammad Amir Hossain, Suprovath Kumar Sarker, Asifuzzaman Rahat, Md Tarikul Islam, Tanjina Noor Haque, Noorjahan Begum, Syeda Kashfi Qadri, A K M Muraduzzaman, Nafisa Nawal Islam, Mohammad Sazzadul Islam, Nusrat Sultana, Manjur Hossain Khan Jony, Farhana Khanam, Golam Mowla, Abdul Matin, Firoza Begum, Tahmina Shirin, Dilruba Ahmed, Narayan Saha, Firdausi Qadri, Kaiissar Mannoor
The study aimed to examine for the first time the spectra of viral and bacterial pathogens along with the antibiotic susceptibility of the isolated bacteria in under-5 children with acute respiratory infections (ARIs) in hospital settings of Dhaka, Bangladesh. Nasal swabs were collected from 200 under-five children hospitalized with clinical signs of ARIs. Nasal swabs from 30 asymptomatic children were also collected. Screening of viral pathogens targeted ten respiratory viruses using RT-qPCR. Bacterial pathogens were identified by bacteriological culture methods and antimicrobial susceptibility of the isolates was determined following CLSI guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/28328944/respiratory-viruses-in-patients-with-influenza-like-illness-in-senegal-focus-on-human-respiratory-adenoviruses
#19
Mbayame Ndiaye Niang, Ndeye Sokhna Diop, Amary Fall, Davy E Kiori, Fatoumata Diene Sarr, Sara Sy, Déborah Goudiaby, Mamadou Aliou Barry, Malick Fall, Ndongo Dia
BACKGROUND: Human adenoviruses (HAdVs) are highly contagious pathogens that are associated with a wide spectrum of human illnesses involving the respiratory tract. In the present study, we investigate the epidemiologic and viral molecular features of HAdVs circulating in Senegal after 4 consecutive years of sentinel surveillance of influenza-like Illness cases. METHODOLOGY AND RESULTS: From January 2012 to December 2015 swabs were collected from consenting ILI outpatients...
2017: PloS One
https://www.readbyqxmd.com/read/28327377/community-acquired-rhinovirus-infection-is-associated-with-changes-in-the-airway-microbiome
#20
Kirsten M Kloepfer, Vishal K Sarsani, Valeriy Poroyko, Wai Ming Lee, Tressa E Pappas, Theresa Kang, Kristine A Grindle, Yury A Bochkov, Sarath Chandra Janga, Robert F Lemanske, James E Gern
No abstract text is available yet for this article.
March 19, 2017: Journal of Allergy and Clinical Immunology
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