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rhinovirus infections in Children

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https://www.readbyqxmd.com/read/28870461/enhanced-plasmacytoid-dendritic-cell-antiviral-responses-after-omalizumab
#1
Michelle A Gill, Andrew H Liu, Agustin Calatroni, Rebecca Z Krouse, Baomei Shao, Allison Schiltz, James E Gern, Alkis Togias, William W Busse
BACKGROUND: Atopy and viral respiratory infections synergistically promote asthma exacerbations. IgE cross-linking inhibits critical viral-induced IFNα responses of plasmacytoid dendritic cells (pDCs), which can be deficient in allergic asthma. OBJECTIVE: To determine whether reducing IgE in vivo with omalizumab treatment increases pDC antiviral IFNα responses in inner city children with asthma. METHODS: PBMCs and pDCs isolated from children with exacerbation-prone asthma before and during omalizumab treatment were stimulated ex vivo with rhinovirus and influenza in the presence or absence of IgE cross-linking...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28864597/parvovirus-b19-infection-in-children-with-arterial-ischemic-stroke
#2
Heather J Fullerton, Jorge M Luna, Max Wintermark, Nancy K Hills, Rafal Tokarz, Ying Li, Carol Glaser, Gabrielle A DeVeber, W Ian Lipkin, Mitchell S V Elkind
BACKGROUND AND PURPOSE: Case-control studies suggest that acute infection transiently increases the risk of childhood arterial ischemic stroke. We hypothesized that an unbiased pathogen discovery approach utilizing MassTag-polymerase chain reaction would identify pathogens in the blood of childhood arterial ischemic stroke cases. METHODS: The multicenter international VIPS study (Vascular Effects of Infection in Pediatric Stroke) enrolled arterial ischemic stroke cases, and stroke-free controls, aged 29 days through 18 years...
September 1, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28852711/enterovirus-d68-in-viet-nam-2009-2015
#3
Nguyen Thi Han Ny, Nguyen To Anh, Vu Thi Ty Hang, Lam Anh Nguyet, Tran Tan Thanh, Do Quang Ha, Ngo Ngoc Quang Minh, Do Lien Anh Ha, Angela McBride, Ha Manh Tuan, Stephen Baker, Pham Thi Thanh Tam, Tran My Phuc, Dang Thao Huong, Tran Quoc Loi, Nguyen Tran Anh Vu, Nguyen Van Hung, Tran Thi Thuy Minh, Nguyen Van Xang, Nguyen Dong, Ho Dang Trung Nghia, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Catherine Anscombe, Tan Le Van
BACKGROUND: Since 1962, enterovirus D68 (EV-D68) has been implicated in multiple outbreaks and sporadic cases of respiratory infection worldwide, but especially in the USA and Europe with an increasing frequency between 2010 and 2014. We describe the detection, associated clinical features and molecular characterization of EV-D68 in central and southern Viet Nam between 2009 and 2015. METHODS: Enterovirus/rhinovirus PCR positive respiratory or CSF samples taken from children and adults with respiratory/central nervous system infections in Viet Nam were tested by an EV-D68 specific PCR...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28822736/-rhinovirus-underestimated-pathogens-in-patients-during-the-neonatal-period
#4
S Zacharie, A Vabret, B Guillois, C Dupont, J Brouard
INTRODUCTION: In recent years, developments in virological tools have led to the easy detection of rhinoviruses and enteroviruses (E/RV). Their detection is very frequent in cases of airway involvement in children and their demonstrated causality. But the morbidity of E/RV in the neonatal period is unknown due to lack of epidemiological data. The objective of this study was to evaluate the incidence and clinical characteristics of these infections in hospitalized neonates. MATERIALS AND METHODS: We retrospectively analyzed the virology specimens of all neonates hospitalized at the Caen University Hospital between 2006 and 2011...
September 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28750058/human-enteroviruses-associated-with-and-without-diarrhea-in-thailand-between-2010-and-2016
#5
Jira Chansaenroj, Supansa Tuanthap, Thanundorn Thanusuwannasak, Ausanee Duang-In, Sirapa Klinfueng, Napha Thaneskongtong, Viboonsuk Vutithanachot, Sompong Vongpunsawad, Yong Poovorawan
Non-bacterial acute gastroenteritis (AGE) associated with virus infection affects individuals living in developing countries, especially children. To investigate whether shedding of certain human enterovirus (EV) is more frequently detected in the stool of individuals with AGE of unknown etiology than individuals without AGE symptoms, we tested fecal samples collected from 2,692 individuals with diarrhea between January 2010 and December 2016. Samples were tested for rotavirus, norovirus, and EV by reverse-transcription polymerase chain reaction (RT-PCR) and adenovirus by PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28747261/enterovirus-d68-infection-in-a-cluster-of-children-with-acute-flaccid-myelitis-buenos-aires-argentina-2016
#6
Victor Ruggieri, Maria Ivana Paz, María Gabriela Peretti, Carlos Rugilo, Rosa Bologna, Cecilia Freire, Silvana Vergel, Andrea Savransky
OBJECTIVE: To report a outbreak of 11 cases of acute asymmetric flaccid myelopathy due to spinal motor neuron injury. MATERIAL AND METHODS: Eleven children, six male, with a mean age of 3 years presented with acute flaccid myelitis. We analyzed clinical features, etiology, neuroradiological images, treatment, and outcome. RESULTS: Nine children had bilateral and asymmetric flaccid myelitis of the upper limbs, 1 had upper limb monoplegia, and 1 presented with hemiparesis...
July 19, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28726613/human-metapneumovirus-and-other-respiratory-viral-infections-during-pregnancy-and-birth-nepal
#7
Jennifer L Lenahan, Janet A Englund, Joanne Katz, Jane Kuypers, Anna Wald, Amalia Magaret, James M Tielsch, Subarna K Khatry, Stephen C LeClerq, Laxman Shrestha, Mark C Steinhoff, Helen Y Chu
Human metapneumovirus (HMPV) is a respiratory virus that can cause severe lower respiratory tract disease and even death, primarily in young children. The incidence and characteristics of HMPV have not been well described in pregnant women. As part of a trial of maternal influenza immunization in rural southern Nepal, we conducted prospective, longitudinal, home-based active surveillance for febrile respiratory illness during pregnancy through 6 months postpartum. During 2011-2014, HMPV was detected in 55 of 3,693 women (16...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28716935/severe-viral-respiratory-infections-in-children-with-ifih1-loss-of-function-mutations
#8
Samira Asgari, Luregn J Schlapbach, Stéphanie Anchisi, Christian Hammer, Istvan Bartha, Thomas Junier, Geneviève Mottet-Osman, Klara M Posfay-Barbe, David Longchamp, Martin Stocker, Samuel Cordey, Laurent Kaiser, Thomas Riedel, Tony Kenna, Deborah Long, Andreas Schibler, Amalio Telenti, Caroline Tapparel, Paul J McLaren, Dominique Garcin, Jacques Fellay
Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring support in intensive care because of a severe illness caused by a respiratory virus. Using exome and transcriptome sequencing, we identified and characterized three rare loss-of-function variants in IFIH1, which encodes an RIG-I-like receptor involved in the sensing of viral RNA...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28709967/advances-in-asthma-in-2016-designing-individualized-approaches-to-management
#9
REVIEW
William C Anderson, Andrea J Apter, Cullen M Dutmer, Daniel A Searing, Stanley J Szefler
In this year's Advances in Asthma review, we discuss viral infections in asthmatic patients and potential therapeutic agents, the microbiome, novel genetic associations with asthma, air quality and climate effects on asthma, exposures during development and long-term sequelae of childhood asthma, patient-centered outcomes research, and precision medicine. In addition, we discuss application of biomarkers to precision medicine and new information on asthma medications. New evidence indicates that rhinovirus-triggered asthma exacerbations become more severe as the degree of sensitization to dust mite and mouse increase...
September 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28680946/etiology-seasonality-and-clinical-features-of-viral-respiratory-tract-infections-in-children-hospitalized-with-acute-bronchiolitis-a-single-center-study
#10
Şule Gökçe, Zafer Kurugöl, Güldane Koturoğlu, Candan Çiçek, Aslı Aslan
The purpose of this study was to evaluate the viral frequency, seasonality, and clinical and demographic features of patients hospitalized with acute bronchiolitis. A cross-sectional, descriptive study was performed in 316 infants younger than 2 years of age who were hospitalized for acute viral bronchiolitis. Respiratory tract infection agents were investigated with polymerase chain reaction (PCR). A total of 316 infants were included in this study. Of the 316 infants, at least one respiratory tract pathogen was detected in 75% (237/316)...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28673837/respiratory-viruses-detected-in-mexican-children-younger-than-5-years-old-with-community-acquired-pneumonia-a-national-multicenter-study
#11
Rosa María Wong-Chew, Miguel L García-León, Daniel E Noyola, Luis F Perez Gonzalez, Jesús Gaitan Meza, Alberto Vilaseñor-Sierra, Gerardo Martinez-Aguilar, Victor Hugo Rivera-Nuñez, Oscar A Newton-Sánchez, Verónica Firo-Reyes, Carlos N Del Río-Almendarez, Alejandra Pamela González-Rodríguez, Enrique R Ortiz-García, Susana Navarrete-Navarro, Carmen Soria-Rodríguez, Adoniram Carrasco-Castillo, Eneida Sánchez-Medina, Irma López-Martínez, Teresa Hernández-Andrade, Celia M Alpuche-Aranda, José I Santos-Preciado
BACKGROUND: Acute respiratory infections are the leading cause of mortality in children worldwide, especially in developing countries. Pneumonia accounts for 16% of all deaths of children under 5 years of age and was the cause of death of 935000 children in 2015. Despite its frequency and severity, information regarding its etiology is limited. The aim of this study was to identify respiratory viruses associated with community-acquired pneumonia (CAP) in children younger than 5 years old...
June 30, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28639594/viral-aetiology-of-wheezing-in-children-under-five
#12
Prithi Sureka Mummidi, Radha Tripathy, Bhagirathi Dwibedi, Amarendra Mahapatra, Suryakanta Baraha
BACKGROUND & OBJECTIVES: Wheezing is a common problem in children under five with acute respiratory infections (ARIs). Viruses are known to be responsible for a considerable proportion of ARIs in children. This study was undertaken to know the viral aetiology of wheezing among the children less than five years of age, admitted to a tertiary care hospital in eastern India. METHODS: Seventy five children, under the age of five years admitted with wheezing, were included in the study...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28628546/the-impact-of-multiple-viral-respiratory-infections-on-outcomes-for-critically-ill-children
#13
Jigar C Chauhan, Nicholas B Slamon
OBJECTIVE: Advances in molecular diagnosis have led to increased testing for single and multiviral respiratory infection in routine clinical practice. This study compares outcomes between single and multiviral respiratory infections in children younger than 5 years old admitted to the PICU with respiratory failure. DESIGN: Retrospective, single-center, cohort study. SETTING: Tertiary-care, freestanding children's hospital. PATIENTS: Children younger than 5 years old admitted to the PICU with respiratory failure and positive respiratory molecular panel...
August 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28627819/analysis-of-respiratory-viral-infections-detected-using-multiplex-real-time-pcr-in-hwaseong-korea-from-2013-to-2015
#14
Dae-Hyun Ko, Jungwon Hyun, Han-Sung Kim, Jae-Seok Kim, Wonkeun Song, Hyun Soo Kim
BACKGROUND: We investigated the incidences and age-related/seasonal variations of respiratory virus infections in a regional area in Korea. METHODS: A total of 3,467 respiratory specimens from patients with acute respiratory infection symptoms in a teaching hospital were tested for respiratory viruses during 2013 - 2015. RESULTS: At least one virus was detected in 2,561 of the 3,467 specimens (73.9%), and 706 patients (20.4%) were positive for two or more viruses...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28608756/effects-of-omalizumab-on-rhinovirus-infections-illnesses-and-exacerbations-of-asthma
#15
Ann Esquivel, William W Busse, Agustin Calatroni, Alkis G Togias, Kristine G Grindle, Yury A Bochkov, Rebecca S Gruchalla, Meyer Kattan, Carolyn M Kercsmar, G Khurana Hershey, Haejin Kim, Petra Lebeau, Andrew H Liu, Stanley J Szefler, Stephen J Teach, Joseph B West, Jeremy Wildfire, Jacqueline A Pongracic, James E Gern
RATIONALE: Allergic inflammation has been linked to increased susceptibility to viral illnesses, but it is unclear whether this association is causal. OBJECTIVE: To test whether omalizumab treatment to reduce IgE would shorten the frequency and duration of rhinovirus illnesses in children with allergic asthma. METHODS: The Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations (PROSE) was a study of children with allergic asthma (6-17 years, n=478) from low-income census tracts in 8 U...
June 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28605562/microorganisms-associated-with-pneumonia-in-children-5-years-of-age-in-developing-and-emerging-countries-the-gabriel-pneumonia-multicenter-prospective-case-control-study
#16
Thomas Bénet, Valentina Sánchez Picot, Mélina Messaoudi, Monidarin Chou, Tekchheng Eap, Jianwei Wang, Kunling Shen, Jean-William Pape, Vanessa Rouzier, Shally Awasthi, Nitin Pandey, Ashish Bavdekar, Sonali Sanghavi, Annick Robinson, Mala Rakoto-Andrianarivelo, Maryam Sylla, Souleymane Diallo, Pagbajabyn Nymadawa, Nymadawaagiin Naranbat, Graciela Russomando, Wilma Basualdo, Florence Komurian-Pradel, Hubert Endtz, Philippe Vanhems, Gláucia Paranhos-Baccalà
Background.: Pneumonia, the leading infectious cause of child mortality globally, mainly afflicts developing countries. This prospective observational study aimed to assess the microorganisms associated with pneumonia in children aged <5 years in developing and emerging countries. Methods.: A multicenter, case-control study by the GABRIEL (Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries) network was conducted between 2010 and 2014 in Cambodia, China, Haiti, India (2 sites), Madagascar, Mali, Mongolia, and Paraguay...
June 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28599066/rhinovirus-and-preschool-wheeze
#17
REVIEW
Katarina Stenberg-Hammar, Gunilla Hedlin, Cilla Söderhäll
Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are, however, conflicting opinions as to whether there are differences in response to RV infection or whether wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children...
June 9, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28588119/high-flow-nasal-cannula-utilization-in-pediatric-critical-care
#18
Kristen D Coletti, Dayanand N Bagdure, Linda K Walker, Kenneth E Remy, Jason W Custer
BACKGROUND: High-flow nasal cannula (HFNC) is increasingly utilized in pediatrics, delivering humidified air and oxygen for respiratory conditions causing hypoxia and distress. In the neonatal ICU, it has been associated with better tolerance, lower complications, and lower cost. Few data exist regarding indications for use and the epidemiology of disease/pathology that warrants HFNC in the pediatric ICU. METHODS: This study is a retrospective cohort study of patients admitted to a tertiary children's hospital pediatric ICU and placed on HFNC from October 1, 2011 to October 31, 2013...
August 2017: Respiratory Care
https://www.readbyqxmd.com/read/28552993/rhinovirus-infection-results-in-stronger-and-more-persistent-genomic-dysregulation-evidence-for-altered-innate-immune-response-in-asthmatics-at-baseline-early-in-infection-and-during-convalescence
#19
Peter W Heymann, Huyen-Tran Nguyen, John W Steinke, Ronald B Turner, Judith A Woodfolk, Thomas A E Platts-Mills, Lisa Martin, Hua He, Jocelyn Biagini Myers, Mark Lindsey, Umasundari Sivaprasad, Mario Medvedovic, Naim Mahi, Holliday Carper, Deborah D Murphy, James Patrie, Gurjit K Khurana Hershey
BACKGROUND: Rhinovirus (HRV) is associated with the large majority of virus-induced asthma exacerbations in children and young adults, but the mechanisms remain poorly defined. METHODS: Asthmatics and non-asthmatic controls were inoculated with HRV-A16, and nasal epithelial samples were obtained 7 days before, 36 hours after, and 7 days after viral inoculation. RNA was extracted and subjected to RNA-seq analysis. RESULTS: At baseline, 57 genes were differentially expressed between asthmatics and controls, and the asthmatics had decreased expression of viral replication inhibitors and increased expression of genes involved in inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28526018/infection-mediated-asthma-etiology-mechanisms-and-treatment-options-with-focus-on-chlamydia-pneumoniae-and-macrolides
#20
REVIEW
Wilmore C Webley, David L Hahn
Asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. The worldwide incidence of asthma has increased dramatically in the last 40 years. According to World Health Organization (WHO) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. It is now well accepted that asthma is a heterogeneous syndrome and many clinical subtypes have been described...
May 19, 2017: Respiratory Research
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