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rhinovirus infections in Children

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https://www.readbyqxmd.com/read/29780032/severe-outcomes-associated-with-respiratory-viruses-in-newborns-and-infants-a-prospective-viral-surveillance-study-in-jordan
#1
Najwa Khuri-Bulos, Lindsey Lawrence, Bhinnata Piya, Li Wang, Christopher Fonnesbeck, Samir Faouri, Asem Shehabi, Sten H Vermund, John V Williams, Natasha B Halasa
OBJECTIVE: To assess virus-specific hospitalisation rates, risk factors for illness severity and seasonal trends in children hospitalised with acute respiratory infections (ARI). DESIGN: Prospective cohort study. SETTING: A government hospital serving low-income and middle-income population in Amman, Jordan. PARTICIPANTS: Children under 2 years of age hospitalised with fever and/or respiratory symptoms (n=3168) from 16 March 2010 to 31 March 2013...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29756703/most-commonly-isolated-viruses-in-asthma-exacerbation-and-their-correlation-with-eosinophil-and-total-serum-immunoglobulin-e-levels
#2
Mireya Robledo Aceves, Alejandro Barrón Balderas, María de L Jaime Ornelas
BACKGROUND: Asthma exacerbations are still a cause of hospitalization at the Emergency Department. The triggers of asthma exacerbations include allergens and infections -mostly viral-. The objective of this study was to establish the relationship between viruses detected during an asthma exacerbation and eosinophil and serum immunoglobulin E (IgE) levels in pediatric patients. POPULATION AND METHODS: Cross-sectional. analytical study. Children aged 5-15 years seen at the Pediatric Emergency Department with an asthma exacerbation in the period between March 2013 and February 2016 were included...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29684211/heterotypic-infection-and-spread-of-rhinovirus-a-b-and-c-among-child-care-attendees
#3
Emily T Martin, Jane Kuypers, Helen Y Chu, Sydney Foote, Andrew Hashikawa, Mary P Fairchok, Janet A Englund
Background: Despite the frequency of human rhinovirus (HRV), data describing the molecular epidemiology of HRV in the community are limited. Child care centers are optimal settings to characterize heterotypic HRV co-circulation. Methods: HRV specimens were prospectively obtained from a cohort of child care attendees at enrollment and weekly during respiratory illness. Sequences of the 5' non-coding region were used to determine HRV species (A, B, or C) and genotypes...
April 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29665312/interleukin-13-associates-with-life-threatening-rhinovirus-infections-in-infants-and-young-children
#4
Mauricio T Caballero, Diego R Hijano, Patricio L Acosta, Cecilia G Mateu, Débora N Marcone, Jodell E Linder, Laura B Talarico, John M Elder, Marcela Echavarria, Eva Kathryn Miller, Fernando P Polack
OBJECTIVE: Delineate risk factors associated with severe hypoxemia (O2 sat ≤87%) in infants and children younger than 2 years hospitalized with single pathogen HRV infection. STUDY DESIGN: Prospective study in a yearly catchment population of 56 560 children <2 years old between 2011 and 2013 in Argentina. All children with respiratory signs and O2 sat <93% on admission were included. HRV infections were identified by reverse transcriptase-polymerase chain reaction...
April 17, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29622672/viral-infections-in-wheezing-disorders
#5
REVIEW
Peter Le Souëf
Over the past year, studies into virus-induced wheeze in children have shifted towards investigations that examine the mechanisms by which respiratory viruses cause wheeze and an increase in studies examining the effects of novel interventions to reduce wheezing exacerbations. Studies on rhinovirus species (RV)-C infection have found that this is associated with a decrease in expression of CDHR3, the cellular receptor specific for this virus, and a decrease in interferon-β expression, both of which are likely to favour RV-C infection...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29615683/non-neutralizing-antibody-responses-against-vp1-in-enterovirus-a-b-c-and-rhinovirus-a-species-among-infants-and-children-in-shanghai
#6
Yingying Ding, Bing Rui, Caixia Gao, Menghua Xu, Lili Wang, Chunyan Zhao, Jie Bai, Jinhong Wang, Jin Xu, Wei Pan
The overall non-neutralizing antibody responses against EV infections among infants and children remain unknown. The non-neutralizing antibody responses against VP1 of EV-A species (Enterovirus 71 (EV71), Coxsackievirus A16 (CA16)), EV-B species (Coxsackievirus B3 (CB3)), EV-C species (Poliovirus 1 (PV1)) and RV-A species (Rhinovirus A N13 (RV13)) were detected and analyzed using a novel evolved immunoglobulin-binding molecule (NEIBM)-based ELISA among infants and children aged 1 day to 6 years in Shanghai...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29562753/nucleosides-for-the-treatment-of-respiratory-rna-virus-infections
#7
Paul C Jordan, Sarah K Stevens, Jerome Deval
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses causing mild seasonal colds. These RNA viruses can also cause lower respiratory tract infections leading to bronchiolitis and pneumonia. Young children, the elderly, and patients with compromised cardiac, pulmonary, or immune systems are at greatest risk for serious disease associated with these RNA virus respiratory infections. In addition, swine and avian influenza viruses, together with severe acute respiratory syndrome-associated and Middle Eastern respiratory syndrome coronaviruses, represent significant pandemic threats to the general population...
January 2018: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29509911/live-attenuated-respiratory-syncytial-virus-vaccine-candidate-with-deletion-of-rna-synthesis-regulatory-protein-m2-2-is-highly-immunogenic-in-children
#8
Elizabeth J McFarland, Ruth A Karron, Petronella Muresan, Coleen K Cunningham, Megan E Valentine, Charlotte Perlowski, Bhagvanji Thumar, Devasena Gnanashanmugam, George K Siberry, Elizabeth Schappell, Emily Barr, Vivian Rexroad, Ram Yogev, Stephen A Spector, Mariam Aziz, Nehali Patel, Mikhaela Cielo, Cindy Luongo, Peter L Collins, Ursula J Buchholz
Background: Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication. Methods: RSV-seronegative children ages 6-24 months received a single intranasal dose of 105 plaque forming units (PFU) of LIDΔM2-2 (n = 20) or placebo (n = 9) (NCT02237209, NCT02040831). RSV serum antibodies, vaccine infectivity, and reactogenicity were assessed...
April 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29506899/respiratory-tract-infections-and-voice-quality-in-4-year-old-children-in-the-steps-study
#9
Emma Kallvik, Laura Toivonen, Ville Peltola, Anne Kaljonen, Susanna Simberg
OBJECTIVES: Health-related factors are part of the multifactorial background of dysphonia in children. Respiratory tract infections affect the same systems and structures that are used for voice production. The purpose of this study was to investigate if the number of respiratory tract infections or the viral etiology were significant predictors for a more hoarse voice quality. METHODS: The participants were 4-year-old children who participated in the multidisciplinary STEPS study (Steps to the Healthy Development and Well-being of Children) where they were followed up from pregnancy or birth to 4 years of age...
March 2, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29498483/enterovirus-d-68-in-children-presenting-for-acute-care-in-the-hospital-setting
#10
Timothy J Savage, Jane Kuypers, Helen Y Chu, Miranda C Bradford, Anne Marie Buccat, Xuan Qin, Eileen J Klein, Keith R Jerome, Janet A Englund, Alpana Waghmare
BACKGROUND: Severe respiratory disease associated with enterovirus D68 (EV-D68) has been reported in hospitalized pediatric patients. Virologic and clinical characteristics of EV-D68 infections exclusively in patients presenting to a hospital Emergency Department (ED) or urgent care have not been well defined. METHODS: Mid-nasal swabs from pediatric patients with respiratory symptoms presenting to the ED or urgent care were evaluated using a commercial multiplex PCR platform...
March 2, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29489664/risk-factors-for-severe-bronchiolitis-caused-by-respiratory-virus-infections-among-mexican-children-in-an-emergency-department
#11
Mireya Robledo-Aceves, María de Jesús Moreno-Peregrina, Fernando Velarde-Rivera, Elba Ascencio-Esparza, Francisco M Preciado-Figueroa, Miguela A Caniza, Griselda Escobedo-Melendez
Severe bronchiolitis is the most common reason for hospitalization among children younger than 2 years. This study analyzed the prevalence of community-acquired respiratory virus infection and the risk factors for hospitalization of Mexican children with severe bronchiolitis treated in an Emergency department.This retrospective study included 134 children 2 years or younger with severe viral bronchiolitis, and 134 healthy age-matched controls. The study period was September 2012 to January 2015. We determined the viral etiology and coinfections with multiple viruses and compared the risk factors detected in children with severe viral bronchiolitis with those in the control group...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29488229/nation-wide-surveillance-of-human-acute-respiratory-virus-infections-between-2013-and-2015-in-korea
#12
Jeong-Min Kim, Hee-Dong Jung, Hyang-Min Cheong, Anna Lee, Nam-Joo Lee, Hyuk Chu, Joo-Yeon Lee, Sung Soon Kim, Jang-Hoon Choi
The prevalence of eight respiratory viruses detected in patients with acute respiratory infections (ARIs) in Korea was investigated through analysis of data recorded by the Korea Influenza and Respiratory Viruses Surveillance System (KINRESS) from 2013 to 2015. Nasal aspirate and throat swabs specimens were collected from 36 915 patients with ARIs, and viral nucleic acids were detected by real-time (reverse-transcription) polymerase chain reaction for eight respiratory viruses, including human respiratory syncytial viruses (HRSVs), influenza viruses (IFVs), human parainfluenza viruses (HPIVs), human coronaviruses (HCoVs), human rhinovirus (HRV), human adenovirus (HAdV), human bocavirus (HBoV), and human metapneumovirus (HMPV)...
February 28, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29486764/impaired-type-i-interferon-regulation-in-the-blood-transcriptome-of-recurrent-asthma-exacerbations
#13
Jose L Gomez, Maria P Diaz, Gustavo Nino, Clemente J Britto
BACKGROUND: Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and adults. Some individuals with asthma have increased susceptibility to viral infections and as a result increased rates of asthma exacerbations. We sought to identify a transcriptomic signature in the blood associated with asthma exacerbations triggered by respiratory infections (AETRI) and determine its association with increased risk for asthma exacerbations...
February 27, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29473978/distinction-between-rhinovirus-induced-acute-asthma-and-asthma-augmented-influenza-infection
#14
G V Guibas, M Tsolia, I Christodoulou, F Stripeli, Z Sakkou, N G Papadopoulos
BACKGROUND: Rhinovirus (RV) is an established trigger of asthma attacks, whereas such a link is less consistent for influenza virus (IFV). OBJECTIVE: In the context of precision medicine, we hypothesized that IFV infection may cause a condition essentially different from RV, and we investigated this by evaluating clinical characteristics of RV/IFV-positive and -negative children with respiratory symptoms and/or fever. METHODS: One thousand two hundred and seven children, 6 months to 13 years old, hospitalized for flu-like illness were recruited in this cross-sectional study...
May 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29467579/viral-and-bacterial-etiologies-of-acute-respiratory-infections-among-children-under-5-years-in-senegal
#15
Dieng Assane, Camara Makhtar, Diop Abdoulaye, Fall Amary, Boiro Djibril, Diop Amadou, Diouf Jean Baptiste Niokhor, Diop Amadou, Loucoubar Cheikh, Dia Ndongo, Niang Mbayame, Fall Lamine, Boye Cheikh Saad Bouh
Acute respiratory infections (ARIs) are the leading cause of infectious disease-related morbidity, hospitalization, and morbidity among children worldwide. This study aimed to assess the viral and bacterial causes of ARI morbidity and mortality in children under 5 years in Senegal. Nasopharyngeal samples were collected from children under 5 years who had ARI. Viruses and bacteria were identified using multiplex real-time reverse transcription-polymerase chain reaction and conventional biochemical techniques, respectively...
2018: Microbiology Insights
https://www.readbyqxmd.com/read/29466680/cytokine-responses-to-rhinovirus-and-development-of-asthma-allergic-sensitization-and-respiratory-infections-during-childhood
#16
Adnan Custovic, Danielle Belgrave, Lijing Lin, Eteri Bakhsoliani, Aurica G Telcian, Roberto Solari, Clare S Murray, Ross P Walton, John Curtin, Michael R Edwards, Angela Simpson, Magnus Rattray, Sebastian L Johnston
BACKGROUND: Immunophenotypes of anti-viral responses, and their relationship with asthma, allergy and lower respiratory tract infections (LRTIs) are poorly understood. We characterized multiple cytokine responses of peripheral-blood mononuclear cells to rhinovirus stimulation, and their relationship with clinical outcomes. METHODS: In a population-based birth cohort, we measured 28 cytokines post-stimulation with rhinovirus-16 in 307 children aged 11 years. We used machine learning to identify patterns of cytokine responses, and related these patterns to clinical outcomes using longitudinal models...
February 21, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29446705/prospective-assessment-of-rhinovirus-symptoms-and-species-recurrence-in-children-with-and-without-an-acute-wheezing-exacerbation
#17
Robert Lethbridge, Franciska Prastanti, Cassandra Robertson, Stephen Oo, Siew-Kim Khoo, Peter N Le Souëf, Ingrid A Laing
To assess if the difference in species-specific immune response to RV-C correlates with a higher frequency of reinfection, shorter time to reinfection, or different symptom severity than infections with RV-A or RV-B. Forty-three patients were enrolled of which 34 were successfully tracked longitudinally over 3 months, with nasal swabs and symptom questionnaires provided every 2 weeks to identify rhinovirus (RV) strains and the concurrent symptomatology. No difference was found in the time to reinfection with an RV species between RV-C and RV-A or RV-B (p = 0...
May 2018: Viral Immunology
https://www.readbyqxmd.com/read/29446483/adenovirus-types-associated-with-severe-respiratory-diseases-a-retrospective-4-year-study-in-kuwait
#18
Wassim Chehadeh, Anfal Al-Adwani, Sonia Elezebeth John, Shaikhah Al-Dhufairi, Hessa Al-Dousari, Maha Alkhaledi, Widad Al-Nakib
Human adenovirus (HAdV) infection can result in a severe respiratory disease. The aim of this study was to identify HAdV types detected in patients hospitalized for severe respiratory illness. The study population consisted of 743 patients with severe respiratory disease admitted to four major hospitals in Kuwait between January 2013 and December 2016. Respiratory specimens were retrospectively screened for 20 respiratory viruses by real-time PCR. The HAdV hexon gene was amplified and directly sequenced, and HAdV types were identified by performing Bayesian phylogenetic analysis...
June 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29406977/emerging-respiratory-viruses-in-children
#19
REVIEW
Jennifer E Schuster, John V Williams
Respiratory viral infections are a leading cause of pediatric disease. Emerging respiratory viruses can cause outbreaks with significant morbidity and mortality or circulate routinely. The rapid identification of pathogens, epidemiologic tracing, description of symptoms, and development of preventative and therapeutic measures are crucial to limiting the spread of these viruses. Some emerging viruses, such as rhinovirus C and influenza C, circulate yearly but were previously undetected due to limited diagnostic methods...
March 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29350877/effects-of-human-rhinovirus-on-epithelial-barrier-integrity-and-function-in-children-with-asthma
#20
K Looi, A G Buckley, P J Rigby, L W Garratt, T Iosifidis, G R Zosky, A N Larcombe, F J Lannigan, K-M Ling, K M Martinovich, E Kicic-Starcevich, N C Shaw, E N Sutanto, D A Knight, A Kicic, S M Stick
BACKGROUND: Bronchial epithelial tight junctions (TJ) have been extensively assessed in healthy airway epithelium. However, no studies have yet assessed the effect of human rhinovirus (HRV) infection on the expression and resultant barrier function in epithelial tight junctions (TJ) in childhood asthma. OBJECTIVES: To investigate the impact of HRV infection on airway epithelial TJ expression and barrier function in airway epithelial cells (AECs) of children with and without asthma...
January 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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