keyword
MENU ▼
Read by QxMD icon Read
search

Respiratory Syncytial Virus Infection in Childrens

keyword
https://www.readbyqxmd.com/read/28324595/recent-advances-in-developing-antiviral-therapies-for-respiratory-syncytial-virus
#1
REVIEW
Brian C Shook, Kai Lin
Respiratory syncytial virus (RSV) infection presents a significant health challenge in small children, the elderly and immunocompromised patients. There is still a high unmet medical need among patients with RSV infection, and no specific antiviral therapy is available. The only approved agents are palivizumab, which has to be given prophylactically, mainly in high-risk infants, and ribavirin, which is rarely used due to toxicity concerns and questionable benefits. Efforts to develop new antiviral agents have been hampered by the perceived need for high safety hurdles in pediatric patient populations use and the lack of well-characterized druggable targets...
April 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28306724/respiratory-dna-viruses-are-undetectable-in-nasopharyngeal-secretions-from-adenotonsillectomized-children
#2
Ronaldo Bragança Martins, Lucas Penna Rocha, Mirela Moreira Prates, Talita Bianca Gagliardi, Balduino Biasoli, Marcelo Junqueira Leite, Guilherme Buzatto, Miguel Angelo Hyppolito, Davi Casale Aragon, Edwin Tamashiro, Fabiana Cardoso Pereira Valera, Eurico Arruda, Wilma Terezinha Anselmo-Lima
Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. Nasopharyngeal washes (NPWs) were obtained from 83 of 120 individuals at variable times post adenotonsillectomy, in the absence of ARI symptoms. A look back at virus detection results in NPWs from the same 83 individuals at the time of tonsillectomy revealed that 73...
2017: PloS One
https://www.readbyqxmd.com/read/28303845/diagnostic-value-of-nasopharyngeal-aspirates-in-children-with-lower-respiratory-tract-infections
#3
Ai-Zhen Lu, Peng Shi, Li-Bo Wang, Li-Ling Qian, Xiao-Bo Zhang
BACKGROUND: The accuracy of nasopharyngeal aspirate (NPA) specimens in detecting lower respiratory pathogens remains controversial. The objective of this study was to evaluate the diagnostic accuracy of aspirates (NPAs) specimen in lower respiratory tract infections (LRTIs) in children. METHODS: The prospective study was designed to collect the data of paired NPAs and bronchoalveolar lavage fluids from children with acute LRTIs from January 2013 to December 2015...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28303835/trends-of-respiratory-syncytial-virus-sub-types-in-children-hospitalised-at-a-tertiary-care-centre-in-jaipur-during-2012-2014
#4
M Anjaneya Swamy, Bharti Malhotra, P V Janardhan Reddy, Jitendra Kumar Tiwari, Neeraj Kumar, Manohar Lal Gupta
Respiratory syncytial virus (RSV) causes high mortality and morbidity in infants. The study was planned to determine the trends of RSV sub-types in hospitalised children. Nasopharyngeal aspirate and throat swabs were collected from the hospitalised children up to 5 years of age. Viral nucleic acid was extracted using easyMAG automated extraction system, and real-time reverse transcription polymerase chain reaction was performed. Total positivity for RSV was found to be 25.40%, predominantly for RSV B (20.03%), followed by RSV A (2...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28301570/human-metapnuemovirus-infections-in-hospitalized-children-and-comparison-with-other-respiratory-viruses-2005-2014-prospective-study
#5
María Luz García-García, Cristina Calvo, Cristina Rey, Beatriz Díaz, Maria Del Mar Molinero, Francisco Pozo, Inmaculada Casas
BACKGROUND: Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV infections with respiratory syncytial virus (HRSV), rhinovirus (HRV), adenovirus and human bocavirus infections in the same population...
2017: PloS One
https://www.readbyqxmd.com/read/28283855/the-role-of-human-parainfluenza-virus-infections-in-the-immunopathology-of-the-respiratory-tract
#6
REVIEW
Malgorzata Pawełczyk, Marek Leszek Kowalski
Viral infections are leading causes of both upper and lower airway acute illness in all age groups of healthy persons, and have also been implicated in the acute exacerbations of chronic respiratory disorders like asthma and COPD. Human rhinovirus, respiratory syncytial virus, influenza virus and coronavirus have been considered as the most important respiratory pathogens and relatively little attention has been paid to the role of parainfluenza viruses (hPIVs). Human parainfluenza viruses are single-stranded RNA viruses belonging to the paramyxovirus family that may evoke lower respiratory infections in infants, children and immunocompromised individuals...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28282391/meteorological-factors-on-the-incidence-of-mp-and-rsv-pneumonia-in-children
#7
Dan-Dan Tian, Rong Jiang, Xue-Jun Chen, Qing Ye
BACKGROUND: Pneumonia is common in children and mostly caused by many pathogens. The aim of this study was to investigate whether the incidence of pediatric mycoplasma pneumoniae (MP) pneumonia and respiratory syncytial virus (RSV) pneumonia was associated with meteorological factors in Hangzhou, China. METHODS: A total of 36500 pneumonia patients were recruited to participate in the study. Nasopharyngeal swabs were collected for the detection of MP and RSV using real-time polymerase chain reaction (RT-PCR) and direct immunofluorescence (DIF) assays, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28277820/influenza-and-other-respiratory-viruses-standardizing-disease-severity-in-surveillance-and-clinical-trials
#8
Barbara Rath, Tim Conrad, Puja Myles, Maren Alchikh, Xiaolin Ma, Christian Hoppe, Franziska Tief, Xi Chen, Patrick Obermeier, Bron Kisler, Brunhilde Schweiger
Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed. Areas covered: We present a composite clinical score allowing individual patient data analyses of disease severity based on systematic literature review and WHO-criteria for uncomplicated and complicated disease. The 22-item ViVI Disease Severity Score showed a normal distribution in a pediatric cohort of 6073 children aged 0-18 years (mean age 3...
February 15, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28276287/benzimidazole-based-derivatives-as-privileged-scaffold-developed-for-the-treatment-of-the-rsv-infection-a-computational-study-exploring-the-potency-and-cytotoxicity-profiles
#9
Elena Cichero, Michele Tonelli, Federica Novelli, Bruno Tasso, Ilenia Delogu, Roberta Loddo, Olga Bruno, Paola Fossa
Respiratory syncytial virus (RSV) has been identified as a main cause of hospitalisation in infants and children. To date, the current therapeutic arsenal is limited to ribavirin and palivizumab with variable efficacy. In this work, starting from a number of in-house series of previously described anti-RSV agents based on the benzimidazole scaffold, with the aim at gaining a better understanding of the related chemical features involved in potency and safety profiles, we applied a computational study including two focussed comparative molecular fields analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28275196/mutating-the-cx3c-motif-in-the-g-protein-should-make-a-live-respiratory-syncytial-virus-vaccine-safer-and-more-effective
#10
S Boyoglu-Barnum, S O Todd, J Meng, T R Barnum, T Chirkova, L M Haynes, S J Jadhao, R A Tripp, A G Oomens, M L Moore, L J Anderson
Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. Through a CX3C chemokine motif ((182)CWAIC(186)) in the G protein, RSV binds to the corresponding chemokine receptor, CX3CR1. Since RSV binding to CX3CR1 contributes to disease pathogenesis, we investigated whether a mutation in the CX3C motif by insertion of an alanine A(186) within the CX3C motif to CX4C ((182)CWAIAC(187)), known to block binding to CX3CR1, might decrease disease...
March 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28275185/broadly-reactive-anti-rsv-g-antibodies-from-exposed-individuals-effectively-inhibit-infection-of-primary-airway-epithelial-cells
#11
B Cortjens, E Yasuda, X Yu, K Wagner, Y B Claassen, A Q Bakker, J B M van Woensel, T Beaumont
Respiratory syncytial virus (RSV) causes severe respiratory disease in young children. Antibodies specific for the RSV prefusion F protein have guided RSV vaccine research and in human serum these antibodies attribute to >90% of the neutralization response, however detailed insight in the composition of the human B cell repertoire against RSV is still largely unknown. In order to study the B cell repertoire of 3 healthy donors for specificity against RSV, CD27(+) memory B cells were isolated and immortalized using BCL6 and Bcl-xL...
March 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28267794/the-interdependencies-of-viral-load-the-innate-immune-response-and-clinical-outcome-in-children-presenting-to-the-emergency-department-with-respiratory-syncytial-virus-associated-bronchiolitis
#12
Felipe-Andrés Piedra, Minghua Mei, Vasanthi Avadhanula, Reena Mehta, Letisha Aideyan, Roberto P Garofalo, Pedro A Piedra
Respiratory syncytial virus (RSV) causes significant infant morbidity and mortality. For decades severe RSV-induced disease was thought to result from an uncontrolled host response to viral replication, but recent work suggests that a strong innate immune response early in infection is protective. To shed light on host-virus interactions and the viral determinants of disease, copy numbers of five RSV genes (NS1, NS2, N, G, F) were measured by quantitative real-time polymerase chain reaction (qPCR) in nasal wash samples from children with RSV-associated bronchiolitis...
2017: PloS One
https://www.readbyqxmd.com/read/28262277/-the-interactions-between-microorganisms-and-the-small-airways-a-paediatric-focus
#13
REVIEW
J de Blic, J Brouard, A Vabret, A Deschildre
The spectrum of respiratory viruses is expanding and emerging diseases have been described regularly over the last fifteen years. The origin of these emerging respiratory viruses may be zoonotic (by crossing species barrier, after changes to RNA viruses such as avian influenza virus type A or coronaviruses), or related to the use of new identification techniques (metapneumovirus, bocavirus). The relationship between bronchiolitis and asthma is now better understood thanks to prospective follow up of birth cohorts...
February 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28259567/pitfalls-in-interpretation-of-ct-values-of-rt-pcr-in-children-with-acute-respiratory-tract-infections
#14
Jérôme O Wishaupt, Tjeerd van der Ploeg, Leo C Smeets, Ronald de Groot, Florens G A Versteegh, Nico G Hartwig
BACKGROUND: The relation between viral load and disease severity in childhood acute respiratory tract infections (ARI) is not fully understood. OBJECTIVES: To assess the clinical relevance of the relation between viral load, determined by cycle threshold (CT) value of real-time reverse transcription-polymerase chain reaction assays and disease severity in children with single- and multiple viral ARI. STUDY DESIGN: 582 children with ARI were prospectively followed and tested for 15 viruses...
February 24, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28253869/reduced-prf1-enhancer-methylation-in-children-with-a-history-of-severe-rsv-bronchiolitis-in-infancy-an-association-study
#15
Magdeldin Elgizouli, Chad Logan, Ruth Grychtol, Dietrich Rothenbacher, Alexandra Nieters, Andrea Heinzmann
BACKGROUND: Acute lower respiratory tract infection is the commonest disease affecting children under five worldwide. Respiratory syncytial virus (RSV) is among the most common causative pathogens. Epidemiological data suggest an association between severe viral respiratory infections in infancy and increased incidence of childhood wheeze and asthma. DNA methylation is involved in immune cell differentiation and identity. It provides an avenue for environmental influences on the genome and therefore has potential as a marker for sustained effects of infectious insults...
March 3, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28250126/respiratory-syncytial-virus-rsv-vaccine-vectored-by-a-stable-chimeric-and-replication-deficient-sendai-virus-protects-mice-without-inducing-enhanced-disease
#16
Marian Alexander Wiegand, Gianni Gori-Savellini, Claudia Gandolfo, Guido Papa, Christine Kaufmann, Eva Felder, Alessandro Ginori, Maria Giulia Disanto, Donatella Spina, Maria Grazia Cusi
Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and elderly people and no marketed vaccine exists. In this study, we generated and analyzed a subunit vaccine against RSV based on a novel genome replication-deficient Sendai virus (SeV) vector. We inserted the RSV F protein, known as a genetically stable antigen, into our vector in a specific way to optimize the vaccine features. Exchanging the ectodomain of the SeV F protein with its counterpart from RSV, we created a chimeric vectored vaccine that contains the RSV F protein as an essential structural component...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28236418/one-year-observational-study-of-palivizumab-prophylaxis-on-infants-at-risk-for-respiratory-syncytial-virus-infection-in-latin-america
#17
Leandro Martin Castillo, Gabriela Bugarin, Juan Carlos Arias, Jairo Israel Barajas Rangel, Maria Elina Serra, Nestor Vain
OBJECTIVE: This study aims to describe real world palivizumab use and effectiveness in high-risk Latin American infants and young children. METHOD: Prospective, multicenter observational study with infants at risk for severe RSV infection who received palivizumab according to routine clinical practice. Subjects were followed for one year with monthly visits after the first dose of palivizumab. An infant was considered adherent if receiving all the expected injections or five or fewer injections within appropriate inter-dose intervals...
February 22, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28226227/protective-and-harmful-immunity-to-rsv-infection
#18
Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by the age of three years and then repeatedly infects throughout life; this it does despite relatively slight variations in antigenicity, apparently by inducing selective immunological amnesia. Inappropriate or dysregulated responses to RSV can be pathogenic, causing disease-enhancing inflammation that contributes to short- and long-term effects...
February 6, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/28213974/molecular-characterization-and-clinical-epidemiology-of-human-respiratory-syncytial-virus-hrsv-a-and-b-in-hospitalized-children-southern-brazil
#19
F B Moreira, C S Rosario, J S Santos, V M Avanzi, M B Nogueira, L R Vidal, S M Raboni
Human respiratory syncytial virus (HRSV) is a major etiologic agent of pediatric respiratory infections. Genetic variability of its glycoprotein G enables HRSV to evade the immune response and determines its seasonal dissemination. This study reports genetic variability and clinical profiles of HRSV-infected patients from Southern Brazil. Seventy positive samples, 78% type A and 22% type B, were analyzed. Of the patients (median age, 6 months; interquartile range, 2-11 years) 16% had co-morbidities and 17% developed severe disease...
February 18, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28199704/respiratory-syncytial-virus-infects-cd4-t-cells-the-frequency-of-circulating-cd4-rsv-t-cells-as-a-marker-of-disease-severity-in-young-children
#20
Silvina Raiden, Inés Sananez, Federico Remes-Lenicov, Julieta Pandolfi, Cecilia Romero, Leonardo De Lillo, Ana Ceballos, Jorge Geffner, Lourdes Arruvito
No abstract text is available yet for this article.
February 12, 2017: Journal of Infectious Diseases
keyword
keyword
82962
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"