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Respiratory Syncytial Virus Infection in Childrens

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https://www.readbyqxmd.com/read/29676365/rapid-detection-of-respiratory-syncytial-virus-in-community-acquired-lower-respiratory-tract-infections-in-children-by-chromatographic-assay
#1
Surinder Kumar, Bhanu Mehra, Gulshan Rai Sethi, Sanjeev R Saigal
Respiratory syncytial virus (RSV) is the single most important viral agent causing pediatric lower respiratory tract infections (LRTIs) worldwide. To evaluate the role of RSV in pediatric LRTIs, we studied 85 children <2 years of age hospitalized for community-acquired LRTIs. Nasopharyngeal aspirates were obtained on admission for the detection of RSV antigen by immunochromatographic assay. Demographic, clinical, and radiological findings for RSV antigen were compared. Data analysis was performed by Chi-square test...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29665348/identification-of-etiologic-agents-of-the-pertussis-like-syndrome-in-children-by-real-time-pcr-method
#2
Shima Mahmoudi, Maryam Banar, Babak Pourakbari, Hediyeh Sadat Alavi, Hamid Eshaghi, Alireza Aziz Ahari, Setareh Mamishi
The aim of this study was to recognize the identity and frequency of etiologic agents of the pertussis-like syndrome in children &lt; 2 years of age. A cross-sectional hospital-based study conducted from August 2014 to August 2015. All children &lt; 2 years of age (n=100) who were suspected as pertussis infected were enrolled in this study and tested for Bordetella pertussis, adenovirus (Adv), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus A (INF-A) by real-time PCR technique...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29660756/use-of-palivizumab-in-germany-report-from-the-german-synagis%C3%A2-registry-2009-2016
#3
Arne Simon, Susanne Gehrmann, Gudrun Wagenpfeil, Stefan Wagenpfeil
BACKGROUND: Following national recommendations, palivizumab is administered in Germany to high-risk infants to prevent hospitalizations related to Respiratory Syncytial Virus infection. METHODS: In this post marketing observational study (German SYNAGIS™ Registry) data on risk factors and the clinical course of children, who received at least one palivizumab injection between 2009-2016 (01 September to June 30) were entered into an internet-based data entry system by the attending physicians after informed consent...
April 16, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29659748/burden-etiology-and-risk-factors-of-respiratory-virus-infections-among-symptomatic-preterm-infants-in-the-tropics-a-retrospective-single-center-cohort-study
#4
Kee Thai Yeo, Rowena de la Puerta, Nancy Wen Sim Tee, Koh Cheng Thoon, Victor S Rajadurai, Chee Fu Yung
Background: The burden of respiratory viral infections (RVIs) among preterm infants in the first few years of life, especially those living in the tropics with year-long transmissions of respiratory viruses, remains unknown. We aimed to describe the clinical epidemiology and associated risk factors for RVIs among symptomatic preterm infants ≤32 weeks up to two years of life. Methods: We performed a data linkage analysis of clinical and hospital laboratory databases for preterm infants born at KK Women's & Children's Hospital, Singapore, from 2005 - 2015...
April 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29651734/palivizumab-use-in-infants-with-down-syndrome-report-from-the-german-synagis%C3%A2-registry-2009-2016
#5
Arne Simon, Susanne Gehrmann, Gudrun Wagenpfeil, Stefan Wagenpfeil
Infants with Down syndrome (DS) face an increased risk of respiratory tract infections. Recent studies describe DS as independent risk factor for a complicated clinical course in infants with respiratory syncytial virus (RSV) infection. The prospective observational German Synagis™ Registry comprises data from 249 children below 25 months of age with DS and palivizumab prophylaxis 2009-2016 (1191 administrations; mean 4.8 per patient and season). The median gestational age and the birth weight in patients without and with DS were 31 versus 37 weeks (P < 0...
April 12, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29624886/burden-and-epidemiology-of-influenza-and-respiratory-syncytial-virus-associated-severe-acute-respiratory-illness-hospitalization-in-madagascar-2011-2016
#6
Joelinotahina H Rabarison, Stefano Tempia, Aina Harimanana, Julia Guillebaud, Norosoa H Razanajatovo, Maherisoa Ratsitorahina, Jean-Michel Heraud
BACKGROUND: Influenza and respiratory syncytial virus (RSV) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza- and RSV-associated hospitalization are limited in Africa. METHODS: We conducted hospital-based surveillance for laboratory-confirmed influenza- and RSV-associated severe acute respiratory illness (SARI) at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011-2016...
April 6, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29622672/viral-infections-in-wheezing-disorders
#7
REVIEW
Peter Le Souëf
Over the past year, studies into virus-induced wheeze in children have shifted towards investigations that examine the mechanisms by which respiratory viruses cause wheeze and an increase in studies examining the effects of novel interventions to reduce wheezing exacerbations. Studies on rhinovirus species (RV)-C infection have found that this is associated with a decrease in expression of CDHR3, the cellular receptor specific for this virus, and a decrease in interferon-β expression, both of which are likely to favour RV-C infection...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29621602/neutrophil-extracellular-traps-possess-anti-human-respiratory-syncytial-virus-activity-possible-interaction-with-the-viral-f-protein
#8
Priscila Silva Sampaio Souza, Lia Vezenfard Barbosa, Larissa Figueiredo Alves Diniz, Gabriel Soares da Silva, Bruno Rafael Pereira Lopes, Pedro Miyadaira Ribeiro Souza, Gabriela Campos de Araujo, Diogo Pessoa, Juliana de Oliveira, Fátima Pereira Souza, Karina Alves Toledo
Human respiratory syncytial virus (hRSV) is one of the main etiological agents of diseases of the lower respiratory tract, and is often responsible for the hospitalization of children and the elderly. To date, treatments are only palliative and there is no vaccine available. The airways of patients infected with hRSV exhibit intense neutrophil infiltration, which is responsible for the release of neutrophil extracellular traps (NETs). These are extracellular structures consisting of DNA associated with intracellular proteins, and are efficient in capturing and eliminating various microorganisms, including some viruses...
April 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29618942/genetic-diversity-of-human-respiratory-syncytial-virus-isolated-among-children-with-acute-respiratory-infections-in-southern-cameroon-during-three-consecutive-epidemic-seasons-2011-2013
#9
Sebastien Kenmoe, Marie-Astrid Vernet, Fabien Miszczak, Julia Dina, Matthieu Schoenhals, Véronique Penlap Beng, Astrid Vabret, Richard Njouom
Background: Human respiratory syncytial virus (HRSV) is the main viral cause of severe lower respiratory tract disease in infants and young children. The aim of this study was to describe for the first time the genetic variability of HRSV in Cameroonian patients living in Yaounde for three consecutive epidemic seasons. Methods: HRSV-positive nasopharyngeal samples detected in children less than 15 years in Yaounde were collected from September 2011 to December 2013...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29617879/prevalence-and-significance-of-substitutions-in-the-fusion-protein-of-respiratory-syncytial-virus-resulting-in-neutralization-escape-from-antibody-medi8897
#10
Qing Zhu, Bin Lu, Patrick McTamney, Susan Palaszynski, Seme Diallo, Kuishu Ren, Nancy D Ulbrandt, Nicole Kallewaard, Weijia Wang, Fiona Fernandes, Steve Wong, Catherine Svabek, Brian Moldt, Mark T Esser, Hong Jing, JoAnn A Suzich
Background: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children. To date, no vaccine is approved for the broad population of healthy infants. MEDI8897, a potent anti-RSV fusion antibody with extended serum half-life is currently under clinical investigation as a potential passive RSV vaccine for all infants. As an RNA virus, RSV is prone to mutation, the possibility of viral escape from MEDI8897 neutralization is a potential concern...
March 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29601448/antibiotic-overuse-in-children-with-respiratory-syncytial-virus-lower-respiratory-tract-infection
#11
Chantal B van Houten, Christiana Naaktgeboren, Brigitte J M Buiteman, Maaike van der Lee, Adi Klein, Isaac Srugo, Irina Chistyakov, Wouter de Waal, Clemens B Meijssen, Pieter W Meijers, Karin M de Winter-de Groot, Tom F W Wolfs, Yael Shachor-Meyouhas, Michal Stein, Elisabeth A M Sanders, Louis J Bont
BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) during the first year of life. Antibiotic treatment is recommended in cases suspected of bacterial co-infection. The aim of this prospective study is to estimate the incidence of bacterial co-infections, and the amount of antibiotic overuse in children infected with RSV using expert panel diagnosis. METHODS: Children one month of age and over with LRTI or fever without source were prospectively recruited in hospitals in the Netherlands and Israel...
March 29, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29599424/epidemiology-and-seasonality-of-respiratory-viruses-detected-from-children-with-respiratory-tract-infections-in-wuxi-east-china
#12
Xiaoli Ge, Yi Guo, JuanJuan Chen, Renjing Hu, Xing Feng
BACKGROUND Respiratory tract infections (RTIs) are the major causes of mortality and morbidity in children and lead to hospitalization in developing countries. However, little is known about the epidemiology and seasonality of respiratory viruses in the pediatric population in Wuxi, East China. MATERIAL AND METHODS We included all patients 14 years of age and below who presented with signs and symptoms of RTIs between January 2010 and December 2016. During this period, a total of 2160 children treated in Wuxi No...
March 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29596527/influenza-virus-16-years-experience-of-clinical-epidemiologic-patterns-and-associated-infection-factors-in-hospitalized-children-in-argentina
#13
Angela Gentile, Maria Florencia Lucion, Maria Del Valle Juarez, Ana Clara Martinez, Viviana Romanin, Julia Bakir, Mariana Viegas, Alicia Mistchenko
BACKGROUND: Influenza is an important cause of acute lower respiratory tract infection (aLRTI), hospitalization, and mortality in children. This study aimed to describe the clinical and epidemiologic patterns and infection factors associated with influenza, and compare case features of influenza A and B. METHODS: In a prospective, cross-sectional study, patients admitted for aLRTI, between 2000 and 2015, were tested for respiratory syncytial virus, adenovirus, influenza, or parainfluenza, and confirmed by fluorescent antibody (FA) or real-time polymerase chain reaction (RT-PCR) assay of nasopharyngeal aspirates...
2018: PloS One
https://www.readbyqxmd.com/read/29593031/central-role-of-the-nf%C3%AE%C2%BAb-pathway-in-the-scgb1a1-expressing-epithelium-in-mediating-respiratory-syncytial-virus-induced-airway-inflammation
#14
Bing Tian, Jun Yang, Yingxin Zhao, Teodora Ivanciuc, Hong Sun, Maki Wakamiya, Roberto P Garofalo, Allan R Brasier
Lower respiratory tract infection with respiratory syncytial virus (RSV) produces profound inflammation. Despite an understanding of the role of adaptive immunity in RSV infection, the identity of the major sentinel cells initially triggering inflammation is controversial. Here we evaluate the role of nonciliated secretoglobin ( Scgb1a1 )-expressing bronchiolar epithelial cells in RSV infection. Knock-in mice expressing a tamoxifen (TMX)-inducible Cre recombinase (CreERTM ) from the Scgb1a1 locus were crossed with mice that harbor a RelA conditional allele ( RelAfl ), with loxP sites flanking exons 5-8 of the Rel homology domain...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29573141/a-multicenter-investigation-of-respiratory-syncytial-viral-infection-in-children-with-hematopoietic-cell-transplantation
#15
Courtney M Rowan, Shira J Gertz, Matt S Zinter, Jerelyn Moffet, Rajinder Ps Bajwa, Jessie L Barnum, Michele Kong
BACKGROUND: Hematopoietic cell transplant (HCT) may be a risk factor for morbidity and mortality from respiratory syncytial virus (RSV). Previous studies have been limited by small sample size. We took a multicenter approach with the goal of better understanding the epidemiology, risk factors, treatment, morbidity and mortality associated with RSV infections among children with HCT in the United States. METHODS: A retrospective, multicenter, cohort study of pediatric HCT recipients diagnosed with RSV infection between January 2010 and December 2014...
March 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29568767/construction-and-characterization-of-a-recombinant-human-respiratory-syncytial-virus-encoding-enhanced-green-fluorescence-protein-for-antiviral-drug-screening-assay
#16
Min Xu, Yue-Ying Jiao, Yuan-Hui Fu, Nan Jiang, Yuan-Bo Zheng, Yi-Fei Yan, Mei Zhang, Yan-Peng Zheng, Wu-Yang Zhu, Xiang-Lei Peng, Jin-Sheng He
Human respiratory syncytial virus (RSV) is the single most important cause of lower respiratory tract disease in infants and young children and a major viral agent responsible for respiratory tract disease in immunosuppressed individuals and the elderly, but no vaccines and antiviral drugs are available. Herein the recombinant RSV (rRSV) encoding enhanced green fluorescence protein (EGFP, rRSV-EGFP) was constructed and the potential for screening anti-RSV drugs was investigated. The recombinant plasmid of pBRATm-rRSV-EGFP, containing T7 transcription cassette composed of T7 promoter, RSV antigenomic cDNA with EGFP gene, HDV ribozyme ( δ ), and T7 terminator in the order of 5' to 3', was constructed and cotransfected into BHK/T7-9 cells together with helper plasmids encoding N, P, L, and M2-1 gene, respectively...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29562753/nucleosides-for-the-treatment-of-respiratory-rna-virus-infections
#17
Paul C Jordan, Sarah K Stevens, Jerome Deval
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses causing mild seasonal colds. These RNA viruses can also cause lower respiratory tract infections leading to bronchiolitis and pneumonia. Young children, the elderly, and patients with compromised cardiac, pulmonary, or immune systems are at greatest risk for serious disease associated with these RNA virus respiratory infections. In addition, swine and avian influenza viruses, together with severe acute respiratory syndrome-associated and Middle Eastern respiratory syndrome coronaviruses, represent significant pandemic threats to the general population...
January 2018: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29553863/reformatting-palivizumab-and-motavizumab-from-igg-to-human-iga-impairs-their-efficacy-against-rsv-infection-in-vitro-and-in-vivo
#18
Shamir R Jacobino, Maaike Nederend, J Frederiek Reijneveld, Daan Augustijn, J H Marco Jansen, Jan Meeldijk, Karli R Reiding, Manfred Wuhrer, Frank E J Coenjaerts, C Erik Hack, Louis J Bont, Jeanette H W Leusen
Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization and mortality in young children. Protective therapy options are limited. Currently, palivizumab, a monoclonal IgG1 antibody, is the only licensed drug for RSV prophylaxis, although other IgG antibody candidates are being evaluated. However, at the respiratory mucosa, IgA antibodies are most abundant and act as the first line of defense against invading pathogens. Therefore, it would be logical to explore the potential of recombinant human IgA antibodies to protect against viral respiratory infection, but very little research on the topic has been published...
March 19, 2018: MAbs
https://www.readbyqxmd.com/read/29548714/respiratory-syncytial-virus-infection-in-elderly-adults
#19
REVIEW
N Haber
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and young children. Reinfections are common throughout adult life with more severe presentations occurring in immunocompromised individuals, subjects with underlying high-risk cardiopulmonary diseases, and in the elderly. There is now a significant body of literature indicating that the impact of RSV in elderly adults is similar to that of non-pandemic influenza, both in the community and in nursing homes...
March 13, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29525802/respiratory-syncytial-virus-bronchiolitis-and-hypertransaminasemia
#20
Salvatore Giordano, Maria Di Gangi, Maria Concetta Failla, Lucrezia Bruno, Veronica Falcone, Piera Dones
Bronchiolitis is the most common disease of the lower respiratory tract occurring in children during their first year of life, becoming the most frequent cause of hospitalization. Although the disease can also be caused by other viruses, more than 70% of bronchiolitis cases are caused by respiratory syncytial virus (RSV). RSV bronchiolitis clinically presents rhinitis, coughing, increased breathing and eating difficulties; the symptoms are usually mild, but in some cases may be so severe as to require hospitalization...
March 1, 2018: Le Infezioni in Medicina
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