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Respiratory Syncytial Virus Infection in Childrens

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https://www.readbyqxmd.com/read/29908103/prevalence-of-human-respiratory-syncytial-virus-infection-in-people-with-acute-respiratory-tract-infections-in-africa-a-systematic-review-and-meta-analysis
#1
Sebastien Kenmoe, Jean Joel Bigna, Estelle Amandine Well, Fredy Brice N Simo, Véronique B Penlap, Astrid Vabret, Richard Njouom
AIM: The epidemiology of Human Respiratory Syncytial virus (HRSV) infection has not yet been systematically investigated in Africa. This systematic review and meta-analysis is to estimate the prevalence of HRSV infections in people with acute respiratory tract infections (ARTI) in Africa. METHOD: We searched PubMed, EMBASE, Africa Journal Online, and Global Index Medicus to identify observational studies published from Jan 1, 2000 to Aug 1, 2017. We used a random-effects model to estimate the prevalence across studies...
June 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29906596/are-we-missing-respiratory-viral-infections-in-infants-and-children-comparison-of-a-hospital-based-quality-management-system-with-standard-of-care
#2
Maren Alchikh, Tim Conrad, Christian Hoppe, Xiaolin Ma, Eeva Broberg, Pasi Penttinen, Janine Reiche, Barbara Biere, Brunhilde Schweiger, Barbara Rath
OBJECTIVES: Hospital-based surveillance of influenza and acute respiratory infections relies on ICD-codes and hospital laboratory reports (Standard-of-Care). It is unclear how many cases are missed with either method, i.e. remain undiagnosed/coded as influenza and other respiratory virus infections. Various influenza-like illness (ILI) definitions co-exist with little guidance on how to use them. We are comparing the diagnostic accuracy of standard surveillance methods with a prospective quality management (QM-Program) at a Berlin children's hospital with the Robert-Koch-Institute (RKI)...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906044/case-report-respiratory-syncytial-virus
#3
Rosalinda Jiménez-Aguilar, María Eugenia Rodriguez-Godoy, Rodolfo Norberto Jiménez-Juarez, María del Carmen Cano-Salas
Background: The Respiratory Syncytial Virus (RSV) is the most important viral pathogen in children under 2 years of age, which warrants hospitalization for a low respiratory infection. 0.5% of children under 5 with RSV infection require hospitalization. The aim of this case is to reaffirm the importance of this virus as a cause of severe disease and to emphasize the importance of adequate diagnosis and management to improve prognosis. Clinical case: Child of 1 year 3 months old, without risk factors for severe infection by respiratory viruses...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905317/human-respiratory-syncytial-virus-subtypes-a-and-b-infection-among-children-attending-primary-and-secondary-health-care-facilities-in-ibadan-nigeria
#4
O Ogunsemowo, D O Olaleye, G N Odaibo
Human respiratory syncytial virus (HRSV) causes high morbidity and mortality in infants and young children. Although a high prevalence of HRSV has been reported in Nigeria, the subtype of the virus circulating in the country is not known. This crosssectional study was therefore designed to determine the subtypes of HRSV circulating among children in Ibadan. Two hundred and thirty-one nasopharyngeal and oropharyngeal swabs were collected from children presenting with respiratory infections in Secondary Health Facility (SHF) as well as those attending immunization centers in Primary Health Centers (PHCs) in Ibadan, Nigeria...
February 2018: Archives of basic and applied medicine
https://www.readbyqxmd.com/read/29895153/rsv-infection-in-a-macrophage-cell-line-activates-the-non-canonical-nf-%C3%AE%C2%BAb-pathway-and-induces-pro-inflammatory-cytokine-expression
#5
O Del Moral-Hernández, C Santiago-Olivares, E Rivera-Toledo, J Gaona, E Castillo-Villanueva, B Gómez
Respiratory syncytial virus (RSV) is a highly prevalent infectious agent that causes severe respiratory tract illnesses in infants and children worldwide. Children who have suffered severe RSV infections during infancy are prone to develop recurrent episodes of wheezing and asthma that may be associated with viral persistence. RSV infections in humans and animal models are characterized by extensive inflammatory responses. Epithelial cell lines acutely infected by RSV have shown activation of the NF-κB signaling through two independent pathways: the canonical pathway, mediated by RelA and p50 subunits, and the non-canonical pathway, mediated by the subunits RelB and p52...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29889810/pathogen-clearance-and-new-respiratory-tract-infections-among-febrile-children-in-zanzibar-investigated-with-multitargeting-real-time-polymerase-chain-reaction-on-paired-nasopharyngeal-swab-samples
#6
Kristina Elfving, Deler Shakely, Maria Andersson, Kimberly Baltzell, Mwinyi I Msellem, Anders Björkman, Andreas Mårtensson, Max Petzold, Birger Trollfors, Magnus Lindh
BACKGROUND: New molecular methods have revealed frequent and often polymicrobial respiratory infections in children in low-income settings. It is not known whether presence of multiple pathogens is due to prolonged infections or to frequent exposure. The aim of this study was to analyze short-term pathogen clearance from nasopharynx and the rate of new respiratory tract infections in febrile preschool children. METHODS: Children (n = 207) with uncomplicated acute febrile illness 2-59 months of age presenting to a health center in Zanzibar, Tanzania, April-July 2011, were included...
July 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29877720/respiratory-virus-prophylaxis-in-congenital-heart-disease
#7
Manjiri Joshi, Robert M R Tulloh
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections and causes up to 200,000 infant deaths a year worldwide. The average rate of hospitalization for severe RSV infection is 5 per 1000 children, and the rate is three-times higher in those with congenital heart disease (CHD). Palivizumab, a monoclonal antibody, reduces hospitalization rates and intensive care admissions. It is used prophylactically and is administered as monthly doses during the RSV season. Hemodynamically unstable CHD is the most susceptible CHD to a severe episode of RSV infection...
June 7, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29868136/prevalence-of-family-history-of-autoimmune-disorders-in-juvenile-systemic-lupus-erythematosus
#8
Parisa Ashournia, Payman Sadeghi, Nima Rezaei, Mohammad-Hassan Moradinejad, Vahid Ziaee
One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Data regarding age, sex, duration of hospitalization, exposure to smoking, previous antibiotic usage and fever were collected for all enrolled cases...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868135/viral-aetiology-of-bronchiolitis-in-hospitalised-children-in-a-tertiary-center-in-tehran
#9
Ali Akbar Rahbarimanesh, Anahita Izadi, Mahsa Ghajarzadeh
One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Data regarding age, sex, duration of hospitalization, exposure to smoking, previous antibiotic usage and fever were collected for all enrolled cases...
March 2018: Mædica
https://www.readbyqxmd.com/read/29866794/respiratory-viruses-and-treatment-failure-in-children-with-asthma-exacerbation
#10
Joanna Merckx, Francine M Ducharme, Christine Martineau, Roger Zemek, Jocelyn Gravel, Dominic Chalut, Naveen Poonai, Caroline Quach
: media-1vid110.1542/5771275574001PEDS-VA_2017-4105 Video Abstract OBJECTIVES: Respiratory pathogens commonly trigger pediatric asthma exacerbations, but their impact on severity and treatment response remains unclear. METHODS: We performed a secondary analysis of the Determinants of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth (DOORWAY) study, a prospective cohort study of children (aged 1-17 years) presenting to the emergency department with moderate or severe exacerbations...
June 4, 2018: Pediatrics
https://www.readbyqxmd.com/read/29863814/improving-the-prescribing-of-palivizumab
#11
Simone Trist, Emily Horsley, Hala Katf, Natalie Tasker, Mona Mostaghim
AIM: Palivizumab prevents respiratory syncytial virus (RSV) in children at high risk of severe disease. This paper reviews the use and effectiveness of palivizumab at two tertiary paediatric hospitals (hospitals A and B) in New South Wales, Australia. METHODS: Children prescribed palivizumab during the pre-intervention period, 1 January 2013 until 31 December 2014, were compared with children under 2 years of age who were admitted to paediatric intensive care units (PICUs) with an RSV infection...
June 4, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29795072/palivizumab-prophylaxis-respiratory-syncytial-virus-and-subsequent-development-of-asthma
#12
Mahir Igde, Hilal Kabasakal, Onur Ozturk, Guner Karatekin, Canan Aygun
BACKGROUND: Respiratory syncytial virus (RSV) infection is a disease commonly encountered during childhood and it may relapse. An experience in the early childhood would induce asthma development in the future. Palivizumab has a proven efficacy for the RSV prophylaxis so it may prevent asthma. Our aim was to evaluate the possible protective effect of palivizumab on the development of asthma by using the modified Asthma Predictive Index (mAPI). METHODS: This study's data consist of 339 children between 2 to 5 years of age followed up in healthy children unit from 2008 to 2011...
June 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29788036/pediatric-investigators-collaborative-network-on-infections-in-canada-picnic-study-of-respiratory-syncytial-virus-associated-deaths-in-pediatric-patients-in-canada-2003-to-2013
#13
Jennifer Tam, Jesse Papenburg, Sergio Fanella, Sandra Asner, Michelle Barton, Cybele Bergeron, Shalini Desai, Charles Hui, Cheryl Foo, Joanne M Langley, Kirk Leifso, My-Linh Ma, Jeffrey Pernica, Joan Robinson, Roopi Singh, Bruce Tapiero, Upton Allen
Background: Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are < 0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized with RSV infection in Canadian pediatric centres. Methods: Retrospective case series of children 18 years of age or younger with RSV-associated deaths at centres affiliated with the Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) over the period 2003- 2013, inclusive...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29780032/severe-outcomes-associated-with-respiratory-viruses-in-newborns-and-infants-a-prospective-viral-surveillance-study-in-jordan
#14
Najwa Khuri-Bulos, Lindsey Lawrence, Bhinnata Piya, Li Wang, Christopher Fonnesbeck, Samir Faouri, Asem Shehabi, Sten H Vermund, John V Williams, Natasha B Halasa
OBJECTIVE: To assess virus-specific hospitalisation rates, risk factors for illness severity and seasonal trends in children hospitalised with acute respiratory infections (ARI). DESIGN: Prospective cohort study. SETTING: A government hospital serving low-income and middle-income population in Amman, Jordan. PARTICIPANTS: Children under 2 years of age hospitalised with fever and/or respiratory symptoms (n=3168) from 16 March 2010 to 31 March 2013...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29777867/antibiotic-exposure-prior-to-respiratory-viral-infection-is-associated-with-progression-to-lower-respiratory-tract-disease-in-allogeneic-hematopoietic-cell-transplant-recipients
#15
Chikara Ogimi, Elizabeth M Krantz, Jonathan L Golob, Alpana Waghmare, Catherine Liu, Wendy M Leisenring, Christopher R Woodard, Sara Marquis, Jane M Kuypers, Keith R Jerome, Steven A Pergam, David N Fredricks, Mohamed L Sorror, Janet A Englund, Michael Boeckh
INTRODUCTION: Recent publications note an association between antibiotic exposure and respiratory viral infections (RVIs). Antibiotics affect microbiota and impair immune response against RVIs in mice, and low microbiome diversity is associated with pulmonary complications including viral lower respiratory tract disease (LRTD) in hematopoietic cell transplantation (HCT) recipients. In this study, we examined whether antibiotic exposure was associated with increased risk of disease progression in RVIs post-transplantation...
May 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29777370/analysis-of-genetic-variability-of-respiratory-syncytial-virus-groups-a-and-b-in-kuwait
#16
Nada Madi, Wassim Chehadeh, Mohammed Asadzadeh, Mariam Al-Turab, Anfal Al-Adwani
Respiratory syncytial virus (RSV) is the most frequently identified viral agent in infants, children, and elderly people with acute respiratory tract infections (ARTIs). This study is the only one of its kind in Kuwait, and its purpose was to investigate the genetic variability of the G protein gene in RSV strains prevalent in Kuwait. Respiratory samples were collected from patients with ARTIs in various hospitals in Kuwait and subjected to reverse transcription PCR (RT-PCR) amplifying a fragment of the G gene of RSV...
May 19, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29771625/a-multifaceted-approach-to-rsv-vaccination
#17
Jorge C G Blanco, Marina S Boukhvalova, Trudy G Morrison, Stefanie N Vogel
Respiratory Syncytial Virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants, resulting in significant morbidity and mortality worldwide. In addition, RSV infections occur throughout different ages, thus, maintaining the virus in circulation, and increasing health risk to more susceptible populations such as infants, the elderly, and the immunocompromised. To date, there is no vaccine approved to prevent RSV infection or minimize symptoms of infection. Current clinical trials for vaccines against RSV are being carried out in four very different populations...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29756703/most-commonly-isolated-viruses-in-asthma-exacerbation-and-their-correlation-with-eosinophil-and-total-serum-immunoglobulin-e-levels
#18
Mireya Robledo Aceves, Alejandro Barrón Balderas, María de L Jaime Ornelas
BACKGROUND: Asthma exacerbations are still a cause of hospitalization at the Emergency Department. The triggers of asthma exacerbations include allergens and infections -mostly viral-. The objective of this study was to establish the relationship between viruses detected during an asthma exacerbation and eosinophil and serum immunoglobulin E (IgE) levels in pediatric patients. POPULATION AND METHODS: Cross-sectional. analytical study. Children aged 5-15 years seen at the Pediatric Emergency Department with an asthma exacerbation in the period between March 2013 and February 2016 were included...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29751747/a-fatal-case-associated-with-respiratory-syncytial-virus-infection-in-a-young-child
#19
Lili Xu, Hengmiao Gao, Jiansheng Zeng, Jun Liu, Cong Lu, Xiaolei Guan, Suyun Qian, Zhengde Xie
BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, and Down syndrome. However, some previously healthy, full-term children who are infected with RSV also require hospitalization and even experience severe sequelae or death. CASE PRESENTATION: In this report, we present the case of an RSV-associated death of a child who was born at full-term and developed normally up to the age of 2 years old...
May 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29750895/predictors-and-incidence-of-hospitalization-due-to-respiratory-syncytial-virus-rsv-associated-lower-respiratory-tract-infection-lrti-in-non-prophylaxed-moderate-to-late-preterm-infants-in-bosnia-and-herzegovina
#20
Hajrija Maksić, Suada Heljić, Fahrija Skokić, Darinka Šumanović-Glamuzina, Veroslava Milošević, Almir Zlatanović, Notario Gerard
Prematurity is a risk factor for respiratory syncytial virus (RSV)-associated lower respiratory tract infections (LRTIs), due to immature humoral and cell-mediated immune system in preterm newborns, as well as their incomplete lung development. Palivizumab, a humanized monoclonal antibody against the F glycoprotein of RSV, is licensed for the prevention of severe RSV LRTI in children at high risk for the disease. This study is a part of a larger observational, retrospective-prospective epidemiological study (PONI) conducted at 72 sites across 23 countries in the northern temperate zone...
April 27, 2018: Bosnian Journal of Basic Medical Sciences
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