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pneumococcal pneumonia in Children

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https://www.readbyqxmd.com/read/29663903/burden-of-influenza-in-less-than-5-year-old-children-admitted-to-hospital-with-pneumonia-in-developing-and-emerging-countries-a-descriptive-multicenter-study
#1
Cédric Dananché, Valentina Sánchez Picot, Thomas Bénet, Mélina Messaoudi, Monidarin Chou, Jianwei Wang, Jean-William Pape, Shally Awasthi, Ashish Bavdekar, Mala Rakoto-Andrianarivelo, Mariam Sylla, Pagbajabyn Nymadawa, Graciela Russomando, Florence Komurian-Pradel, Hubert Endtz, Gláucia Paranhos-Baccalà, Philippe Vanhems, On Behalf Of The Pneumonia Gabriel Network
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29649269/carriage-of-streptococcus-pneumoniae-haemophilus-influenzae-moraxella-catarrhalis-and-staphylococcus-aureus-in-indonesian-children-a-cross-sectional-study
#2
Eileen M Dunne, Chrysanti Murad, Sunaryati Sudigdoadi, Eddy Fadlyana, Rodman Tarigan, Sang Ayu Kompiyang Indriyani, Casey L Pell, Emma Watts, Catherine Satzke, Jason Hinds, Nurhandini Eka Dewi, Finny Fitry Yani, Kusnandi Rusmil, E Kim Mulholland, Cissy Kartasasmita
Streptococcus pneumoniae is an important cause of infection and commonly colonizes the nasopharynx of young children, along with other potentially pathogenic bacteria. The objectives of this study were to estimate the carriage prevalence of S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in young children in Indonesia, and to examine interactions between these bacterial species. 302 healthy children aged 12-24 months were enrolled in community health centers in the Bandung, Central Lombok, and Padang regions...
2018: PloS One
https://www.readbyqxmd.com/read/29610257/comparison-of-immunogenicity-and-protection-of-two-pneumococal-protein-vaccines-based-on-psaa-and-pspa
#3
Jinfei Yu, Bo Li, Xiaorui Chen, Jingcai Lu, Dandan Wang, Tiejun Gu, Wei Kong, Yongge Wu
Streptococcus pneumoniae is a major cause of invasive pneumococcal disease, septicemia and meningitis that can result in high morbidity rates in children under five years old. The current polysaccharide-based vaccines can provide type-specific immunity, but a broad spectrum vaccine would provide greater coverage. Therefore, developing pneumococcal protein-based vaccines that can extend to more sera types is highly important.In this study, we vaccinated mice with a systemic vaccine via the subcutaneous (s.c...
April 2, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29609548/effectiveness-of-13-pneumococcal-conjugate-vaccine-pcv13-against-invasive-pneumococcal-disease-in-children-in-the-dominican-republic
#4
Sara Tomczyk, Fernanda C Lessa, Jacqueline Sánchez, Chabela Peña, Josefina Fernández, M Gloria Carvalho, Fabiana Pimenta, Doraliza Cedano, Cynthia G Whitney, Jennifer R Verani, Hilma Coradin, Zacarías Garib, Lucia Helena De Oliveira, Jesús Feris-Iglesias
BACKGROUND: Limited data are available on the effectiveness of 13-valent pneumococcal conjugate vaccine (PCV13) in resource-poor settings and PCV naïve populations. The Dominican Republic introduced PCV13 in September 2013 using a 2 + 1 schedule (2, 4, and 12 months) without a catch-up campaign. We evaluated PCV13 effectiveness against vaccine-type (VT) invasive pneumococcal disease (IPD) among children in the Dominican Republic. METHODS: We conducted a matched case-control study...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29603797/reductions-in-otitis-and-other-respiratory-tract-infections-following-childhood-pneumococcal-vaccination
#5
Urban Johansson Kostenniemi, Jessica Palm, Sven-Arne Silfverdal
AIM: Streptococcus pneumoniae commonly causes respiratory tract infections including acute otitis media and pneumonia. In this study, we evaluated the impact of general infant pneumococcal vaccination, introduced in Sweden in 2009, on respiratory tract infections. METHODS: We studied the incidence of respiratory tract infections and antibiotic consumption in Västerbotten County, Sweden, during 2005-2014 by using the County Council's diagnosis register. RESULTS: Comparing the pre-vaccination period of 2005-2008 to 2014, the incidences of all-cause acute otitis media decreased significantly in children aged 0-4 and 5-17 years, by 41...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29601605/increased-carriage-of-non-vaccine-serotypes-with-low-invasive-disease-potential-four-years-after-switching-to-the-10-valent-pneumococcal-conjugate-vaccine-in-the-netherlands
#6
Marloes Vissers, Alienke J Wijmenga-Monsuur, Mirjam J Knol, Paul Badoux, Marlies A van Houten, Arie van der Ende, Elisabeth A M Sanders, Nynke Y Rots
The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in The Netherlands in 2006 and was replaced by PHiD-CV10 in 2011. Data on carriage prevalence of S. pneumoniae serotypes in children and invasive pneumococcal disease (IPD) in children and older adults were collected to examine the impact of PCVs on carriage and IPD in The Netherlands. Pneumococcal carriage prevalence was determined by conventional culture of nasopharyngeal swabs in 24-month-old children in 2015/2016. Data were compared to similar carriage studies in 2005 (pre-PCV7 introduction), 2009, 2010/2011 and 2012/2013...
2018: PloS One
https://www.readbyqxmd.com/read/29599766/room-temperature-stable-pspa-based-nanovaccine-induces-protective-immunity
#7
Danielle A Wagner-Muñiz, Shannon L Haughney, Sean M Kelly, Michael J Wannemuehler, Balaji Narasimhan
Streptococcus pneumoniae is a major causative agent of pneumonia, a debilitating disease particularly in young and elderly populations, and is the leading worldwide cause of death in children under the age of five. While there are existing vaccines against S. pneumoniae , none are protective across all serotypes. Pneumococcal surface protein A (PspA), a key virulence factor of S. pneumoniae , is an antigen that may be incorporated into future vaccines to address the immunological challenges presented by the diversity of capsular antigens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29588913/dynamics-of-colonization-of-streptococcus-pneumoniae-strains-in-healthy-peruvian-children
#8
Kristin N Nelson, Carlos G Grijalva, Sopio Chochua, Paulina A Hawkins, Ana I Gil, Claudio F Lanata, Marie R Griffin, Kathryn M Edwards, Keith P Klugman, Jorge E Vidal
Background: Although asymptomatic carriage of Streptococcus pneumoniae ( Spn ) is common, acquisition of the bacteria is the first step in disease pathogenesis. We examined the effect of introduction of the 7-valent pneumococcal vaccine on Spn carriage patterns in a cohort of Peruvian children. Methods: We used data from a prospective cohort study that collected monthly nasopharyngeal samples from children under 3 years of age. Spn isolates were serotyped using Quellung reactions, and bacterial density was determined by quantitative polymerase chain reaction...
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29588912/changes-over-time-in-nasopharyngeal-colonization-in-children-under-2-years-of-age-at-the-time-of-diagnosis-of-acute-otitis-media-1999-2014
#9
Judith M Martin, Alejandro Hoberman, Nader Shaikh, Timothy Shope, S Onika Bhatnagar, Stan L Block, Mary Ann Haralam, Marcia Kurs-Lasky, Michael Green
Background: In children with acute otitis media (AOM), a decrease in nasopharyngeal (NP) colonization with vaccine serotypes of Streptococcus pneumoniae has been noted since the introduction of pneumococcal conjugate vaccines (PCVs). The purpose of this study is to describe corresponding changes in colonization with Haemophilus influenzae. Methods: In 4 separate studies, we obtained NP cultures from children aged 6-23 months presenting with AOM. Cohort 1 was recruited before routine use of PCV7 (1999-2000); 93% of children in cohort 2 (2003-2005) and 100% in cohort 3 (2006-2009) received ≥2 doses of PCV7...
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29549211/role-of-viral-and-bacterial-pathogens-in-causing-pneumonia-among-western-australian-children-a-case-control-study-protocol
#10
Mejbah Uddin Bhuiyan, Thomas L Snelling, Rachel West, Jurissa Lang, Tasmina Rahman, Meredith L Borland, Ruth Thornton, Lea-Ann Kirkham, Chisha Sikazwe, Andrew C Martin, Peter C Richmond, David W Smith, Adam Jaffe, Christopher C Blyth
INTRODUCTION: Pneumonia is the leading cause of childhood morbidity and mortality globally. Introduction of the conjugate Haemophilus influenzae B and multivalent pneumococcal vaccines in developed countries including Australia has significantly reduced the overall burden of bacterial pneumonia. With the availability of molecular diagnostics, viruses are frequently detected in children with pneumonia either as primary pathogens or predispose to secondary bacterial infection. Many respiratory pathogens that are known to cause pneumonia are also identified in asymptomatic children, so the true contribution of these pathogens to childhood community-acquired pneumonia (CAP) remains unclear...
March 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29546928/-streptococcus-pneumoniae-endocarditis-in-a-child-a-case-report
#11
Florencia Escarrá, Ana G Fedullo, Natalia Veliz, Julián Rosa, Rodrigo Oribe, Marisa Di Santo, Bqca Vanesa Reijtman, Lic Alejandra Mastroianni, Guadalupe Pérez
INTRODUCTION: the incidence of invasive infections caused by pneumococcus (Streptococcus pneumoniae) has declined since generalized vaccination with pneumococcal conjugated vaccine, but it is still a prevalent pathogen in children. Amongst pneumococcal invasive infections, IE (infectious endocarditis) is rare, with an incidence between 1 and 7%. CASE REPORT: We describe the case of a previously healthy 4 year old boy, who had received one dose of 10-valent pneumococcal conjugate vaccine who presents with fever, a new heart murmur and heart failure...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29540644/the-incidence-of-pediatric-invasive-bacterial-diseases-in-nippon-medical-school-chiba-hokusoh-hospital-before-and-after-the-introduction-of-conjugate-vaccines
#12
Toumi Sano, Tamaho Suzuki, Ayako Nishigori, Chiharu Miyatake, Shinya Koizumi, Kiyohiko Kaizu, Atsushi Fujita, Mitsuhiro Kamisago, Bin Chang, Naruhiko Ishiwada, Takeshi Asano
The introduction of the Haemophilus influenzae type b (Hib) vaccine and the 7-valent pneumococcal conjugate vaccine (PCV7) has led to dramatic reductions in cases of invasive H. influenzae disease and invasive pneumococcal disease (IPD). After the introduction of the PCV7 and the 13-valent pneumococcal conjugate vaccine (PCV13), the number of children with IPD markedly decreased in our hospital. However, since 2015, three children with IPD have been admitted to our hospital. We analyzed the serotype, multilocus sequence type, and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in these newly diagnosed cases...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29538080/emerging-concepts-in-pleural-infection
#13
Ka Pang Chan, Deirdre B Fitzgerald, Y C Gary Lee
PURPOSE OF REVIEW: Pleural infection remains an important pulmonary disease, causing significant morbidity and mortality. There is a resurgence of disease burden despite introduction of antibiotics and pneumococcal vaccines. A revisit of the pathogenesis and update on intervention may improve the care of pleural infection. RECENT FINDINGS: Recent studies have uncovered the prognostic implication of the presence of a pleural effusion in patients with pneumonia. Identifying where the bacteria lives may have diagnostic and therapeutic implications...
March 13, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29538078/why-is-the-rate-of-pneumococcal-pneumonia-declining
#14
Carlos M Luna, Laura Pulido, Diego Burgos
PURPOSE OF REVIEW: As Streptococcus pneumoniae was considered the etiological agent of nearly all the cases of pneumonia at the beginning of the 20th century, and today is identified in fewer than 10-15% of cases, we analyze the possible causes of such a decline. RECENT FINDINGS: Extensive use of early empiric antimicrobial therapy, discovery of previously unrecognized pathogens, availability to newer diagnostic methods for the recognition of the pneumonia pathogens (PCR, urinary antigens, monoclonal antibodies etc...
March 13, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29533176/characterisation-of-streptococcus-pneumoniae-isolates-from-invasive-disease-in-adults-following-the-introduction-of-pcv10-in-brazil
#15
Bernard Louizette Christophe, Mariana Mott, Gabriela da Cunha, Juliana Caierão, Pedro D Azevedo, Cícero Dias
PURPOSE: Invasive pneumococcal disease (IPD) in the elderly is an important public health issue due to the increased proportion of this population in many countries including Brazil. We aimed to characterise pneumococci isolates in adults >50 years with IPD, following the introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) as part of the National Childhood Immunisation Program for children ≤2 years in March 2010. METHODOLOGY: Between 2013 and 2015, pneumococcal isolates were collected and serotypes were determined using multiplex PCR and/or Quellung reaction...
March 13, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29510484/trends-in-pediatric-complicated-pneumonia-in-an-ontario-local-health-integration-network
#16
Tahereh Haji, Adam Byrne, Tom Kovesi
Following the introduction of 7-valent pneumococcal vaccine (PCV7), while overall rates of invasive pneumococcal disease and pneumococcal pneumonia in children declined, rates of empyema increased. We examined changes in the incidence of hospitalization for pediatric complicated pneumonia (PCOMP) in Eastern Ontario, Canada, particularly since the introduction of the 13-valent vaccine (PCV13). A retrospective chart review was carried out evaluating previously healthy children admitted with PCOMP, which included empyema, parapneumonic effusion, necrotizing pneumonia, and lung abscess between 2002 and 2015...
March 3, 2018: Children
https://www.readbyqxmd.com/read/29505020/low-serum-fetuin-a-as-a-biomarker-to-predict-pneumococcal-necrotizing-pneumonia-and-hemolytic-uremic-syndrome-in-children-erratum
#17
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29503110/vaccine-preventable-disease-incidence-of-pneumococcal-conjugate-vaccine-in-the-finnish-invasive-pneumococcal-disease-vaccine-trial
#18
Arto A Palmu, Jukka Jokinen, Heta Nieminen, Hanna Rinta-Kokko, Esa Ruokokoski, Taneli Puumalainen, Marta Moreira, Lode Schuerman, Dorota Borys, Terhi M Kilpi
Estimation of the full disease burden caused by Streptococcus pneumoniae is challenging due to the difficulties in assigning the aetiology especially in lower and upper respiratory infections. We estimated the pneumococcal disease burden by using the vaccine-preventable disease incidence (VPDI) of PHiD-CV10 vaccine (GSK) in our clinical trial setting. Finnish Invasive Pneumococcal disease (FinIP) trial was a cluster-randomized, double-blind trial in children <19 months who received PHiD-CV10 in 52 clusters or hepatitis B/A vaccine as control in 26 clusters according to 3+1 or 2+1 schedules (infants < 7 months) or catch-up schedules (children 7-18 months)...
March 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29495194/-expert-consensus-on-immunization-for-prevention-of-pneumococcal-disease-in-china-2017
#19
(no author information available yet)
Pneumococcal disease is one of the serious global public health problems, and an important leading cause of the morbidity and mortality of children and adults in China. Currently, antibiotics are the most choices for its clinical treatment. However, antibiotic resistance of Streptococcus pneumoniae has become a severe problem around the world due to the wide use of antibiotics. Hence, the prevention of pneumococcal disease by using pneumococcal vaccines is of great importance. In this article, we reviewed the etiology, clinic, epidemiology, disease burden of pneumococcal disease, and the vaccinology of pneumococcal vaccines, based on the Pneumococcal Vaccines WHO Position Paper (2012) and other latest evidence globally, to introduce comprehensive knowledge of pneumococcal disease, and for the purpose to improve the capacity of the professionals working on pneumococcal disease control and prevention and to provide appropriate evidences of pneumococcal vaccine applications for people who are engaged in public health and immunization vaccination...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29488456/nasopharyngeal-carriage-of-streptococcus-pneumoniae-in-children-in-coastal-kenya
#20
Claire J Heath, Monica Nayakwadi-Singer, Charles H King, Indu Malhotra, Francis Mutuku, Dunstan Mukoko, A Desiree LaBeaud
Streptococcus pneumoniae (SP) is a leading cause of child mortality globally, killing around half a million children aged 5 years and less per year. Nasopharyngeal carriage of SP is a prerequisite to disease, and the prevalence of colonization reaches 100% within the first few years of life. Serotype prevalence varies geographically, impacting the serotype coverage of pneumococcal vaccines, and serotype prevalence data are limited from large regions of the world, including sub-Saharan Africa. We enrolled 323 unvaccinated children, aged 4-7 years from coastal Kenya and obtained nasopharyngeal swab samples before and after vaccination with the 10-valent pneumococcal vaccine...
February 26, 2018: American Journal of Tropical Medicine and Hygiene
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