keyword
https://read.qxmd.com/read/38460060/expert-consensus-on-the-diagnosis-and-treatment-of-end-stage-liver-disease-complicated-by-infections
#1
EDITORIAL
Tao Chen, Guang Chen, Guiqiang Wang, Sombat Treeprasertsuk, Cosmas Rinaldi Adithya Lesmana, Han-Chieh Lin, Mamun Al-Mahtab, Yogesh K Chawla, Soek-Siam Tan, Jia-Horng Kao, Man-Fung Yuen, Guan-Huei Lee, Diana Alcantara-Payawal, Nobuaki Nakayama, Zaigham Abbas, Wasim Jafri, Dong-Joon Kim, Ashok Choudhury, Rakhi Mahiwall, Jinlin Hou, Saeed Hamid, Jidong Jia, J S Bajaj, Fusheng Wang, Shiv K Sarin, Qin Ning
End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or progression of liver decompensation. Consequently, infections are among the most common complications of disease deterioration. There is an overwhelming need for standardized protocols for early diagnosis and appropriate management for patients with ESLD complicated by infections...
March 9, 2024: Hepatology International
https://read.qxmd.com/read/38453406/inpatient-deaths-by-medical-service-characteristics-in-a-comprehensive-cancer-centre
#2
JOURNAL ARTICLE
Sebastiano Mercadante, Alessio Lo Cascio, Alessandra Casuccio
AIM: To examine the intensity of care in the last 3 days of life in different medical settings of a comprehensive cancer centre. METHODS: In this retrospective study, the charts of patients who died in hospital from July 2019 to June 2023 were reviewed. The units taken into consideration were acute palliative care unit (APCU), oncology (ONC) and haematology (HEM), which included also the transplantation unit. Age, gender, diagnosis, Karnofsky or Eastern Cooperative Oncology Group, drugs used in the last 3 days of life, respiratory support, transfusion, parenteral nutrition, imaging studies, blood gas analysis, biochemistry, consultations and endoscopy were retrieved...
March 7, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38450451/utilization-of-medical-interventions-in-hospitalized-mexican-adults-with-cancer-at-the-end-of-life-in-a-referral-hospital-the-importance-of-early-palliative-care
#3
JOURNAL ARTICLE
Silvia Rosa Allende-Pérez, Nadia Cristina Sandoval-Carrera, Leticia Asencio-Huertas, Oscar Rodríguez-Mayoral, Jacob Jonatan Cruz-Sánchez, Emma Verástegui-Avilés
OBJECTIVES: To investigate the impact of early vs. late palliative care (PC) on the frequency of admissions to acute hospital settings and the utilization of end-of-life (EoL) interventions in cancer decedents. METHODS: In this single-center, cross-sectional study, we examined the frequency of intensive care unit (ICU) and emergency department (ED) admissions among adult cancer decedents between 2018 and 2022 in a referral hospital in México. Additionally, we assessed EoL medical interventions, categorizing patients into 3 groups: those who received early PC (EPC), late PC (LPC), and those who did not receive PC (NPC)...
March 7, 2024: Palliative & Supportive Care
https://read.qxmd.com/read/38412948/effects-of-a-commercial-feed-additive-used-for-prophylactic-purposes-on-health-and-blood-parameters-in-neonatal-calves
#4
JOURNAL ARTICLE
Samet Köse, Adnan Şehu
OBJECTIVE: Neonatal calf diarrhea is commonly observed worldwide and leads to significant economic losses. The objective of this study was to investigate the effect of a feed additive supplemented with milk on the incidence of diarrhea days with scours, fecal score, average daily gain, fecal bacterial concentration, and blood parameters in neonatal calves. MATERIALS AND METHODS: Forty Holstein-Friesian crossbreed (HF x Montbeliarde) calves were divided into control (C) and experimental (E) groups, each containing 20 calves...
February 2024: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://read.qxmd.com/read/38404200/a-systematic-efficacy-analysis-of-tuberculosis-treatment-with-bpal-containing-regimens-using-a-multiscale-modeling-approach
#5
JOURNAL ARTICLE
Maral Budak, Laura E Via, Danielle M Weiner, Clifton E Barry, Pariksheet Nanda, Gabrielle Michael, Khisimuzi Mdluli, Denise Kirschner
Tuberculosis (TB) is a life-threatening infectious disease. The standard treatment is up to 90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol [HRZE]) over long time periods. This harsh treatment process causes adherence issues for patients because of the long treatment times and a myriad of adverse effects. Therefore, the World Health Organization has focused goals of shortening standard treatment regimens for TB in their End TB Strategy efforts, which aim to reduce TB-related deaths by 95% by 2035...
February 26, 2024: CPT: Pharmacometrics & Systems Pharmacology
https://read.qxmd.com/read/38395078/robotic-simple-cystectomy-as-a-last-resort-for-antibiotic-recalcitrant-recurrent-urinary-tract-infections-in-women
#6
JOURNAL ARTICLE
Caitlin E Carlton, Alana L Christie, Bonnie C Prokesch, Tze-Chen Chao, Maude E Carmel, Gary E Lemack, Ramy Goueli, Vitaly Margulis, Philippe E Zimmern
OBJECTIVES: To report a series of women with antibiotic-recalcitrant recurrent urinary tract infections (rUTI) managed with robotic simple cystectomy and ileal conduit urinary diversion. METHODS: Following Institutional Review Board approval, all female patients who underwent robotic cystectomy for rUTI between 2011-2021 were identified from a prospectively-maintained internal database at a tertiary care center. Exclusion criteria included interstitial cystitis, neurogenic bladder, urinary tract neoplasm, or congenital abnormality...
February 21, 2024: Urology
https://read.qxmd.com/read/38389542/insights-into-additional-lactone-based-signaling-circuits-in-streptomyces-existence-of-acyl-homoserine-lactones-and-luxi-luxr-homologs-in-six-streptomyces-species
#7
JOURNAL ARTICLE
Amir Salehi-Najafabadi, Sepand Tehrani Fateh, Ghasem Amoabediny, Javad Hamedi
Acyl-homoserine lactones (AHLs), mediating pivotal physiological activities through quorum sensing (QS), have conventionally been considered limited to Gram-negative bacteria. However, few reports on the existence of AHLs in Gram-positive bacteria have questioned this conception. Streptomyces , as Gram-positive bacteria already utilizing a lactone-based QS molecule (i.e., gamma-butyrolactones), are yet to be explored for producing AHLs, considering their metabolic capacity and physiological distinction. In this regard, our study examined the potential production of AHLs within Streptomyces by deploying HPLC-MS/MS methods, which resulted in the discovery of multiple AHL productions by S...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38349160/removal-of-common-antimicrobial-agents-by-sustained-low-efficiency-dialysis
#8
JOURNAL ARTICLE
Joanna Q Hudson, Madelyn N Hilgers, Elvira O Gosmanova
Adequate dosing of antimicrobials is paramount for treating infections in critically ill patients undergoing kidney replacement therapy; however, little is known about antimicrobial removal by sustained low-efficiency dialysis (SLED). The objective was to quantify the removal of cefepime, daptomycin, meropenem, piperacillin-tazobactam, and vancomycin in patients undergoing SLED. Adult patients ≥18 years with acute kidney injury (AKI) or end-stage kidney disease receiving one of the select antimicrobials and requiring SLED were included...
February 13, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38315025/photochemical-inactivation-as-an-alternative-method-to-produce-a-whole-cell-vaccine-for-uropathogenic-escherichia-coli-upec
#9
JOURNAL ARTICLE
Marlena M Westcott, Alexis E Morse, Gavin Troy, Maria Blevins, Thomas Wierzba, John W Sanders
Uropathogenic Escherichia coli (UPEC) is the primary causative agent of lower urinary tract infection (UTI). UTI presents a serious health risk and has considerable secondary implications including economic burden, recurring episodes, and overuse of antibiotics. A safe and effective vaccine would address this widespread health problem and emerging antibiotic resistance. Killed, whole-cell vaccines have shown limited efficacy to prevent recurrent UTI in human trials. We explored photochemical inactivation with psoralen drugs and UVA light (PUVA), which crosslinks nucleic acid, as an alternative to protein-damaging methods of inactivation to improve whole-cell UTI vaccines...
February 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38305378/a-randomized-double-blind-phase-3-safety-and-efficacy-study-of-ridinilazole-versus-vancomycin-for-treatment-of-clostridioides-difficile-infection-clinical-outcomes-with-microbiome-and-metabolome-correlates-of-response
#10
JOURNAL ARTICLE
Pablo C Okhuysen, Mayur S Ramesh, Thomas Louie, Nino Kiknadze, Julian Torre-Cisneros, Claudia Murta de Oliveira, Christophe Van Steenkiste, Alena Stychneuskaya, Kevin W Garey, Julia Garcia-Diaz, Jianling Li, Esther Duperchy, Betty Y Chang, Juthamas Sukbuntherng, Jose G Montoya, Lori Styles, Fong Clow, Danelle James, Erik R Dubberke, Mark Wilcox
BACKGROUND: Exposure to antibiotics predisposes to dysbiosis and Clostridioides difficile infection (CDI) that can be severe, recurrent (rCDI), and life-threatening. Nonselective drugs that treat CDI and perpetuate dysbiosis are associated with rCDI, in part due to loss of microbiome-derived secondary bile acid (SBA) production. Ridinilazole is a highly selective drug designed to treat CDI and prevent rCDI. METHODS: In this phase 3 superiority trial, adults with CDI, confirmed with a stool toxin test, were randomized to receive 10 days of ridinilazole (200 mg twice daily) or vancomycin (125 mg 4 times daily)...
February 2, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38301076/state-of-the-art-review-use-of-antimicrobials-at-the-end-of-life
#11
JOURNAL ARTICLE
Daniel Karlin, Christine Pham, Daisuke Furukawa, Ishminder Kaur, Emily Martin, Olivia Kates, Tara Vijayan
Navigating antibiotics at the end of life is a challenge for infectious disease (ID) physicians who remain deeply committed to providing patient-centered care and engaging in shared decision making. ID physicians, who often see patients in both inpatient and outpatient settings and maintain continuity of care for patients with refractory or recurrent infections, are ideally situated to provide guidance that aligns with patients' goals and values. Complex communication skills, including navigating difficult emotions around end-of-life care, can be used to better direct shared decision making and assist with antibiotic stewardship...
February 1, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38301074/executive-summary-state-of-the-art-review-use-of-antimicrobials-at-the-end-of-life
#12
JOURNAL ARTICLE
Daniel Karlin, Christine Pham, Daisuke Furukawa, Ishminder Kaur, Emily Martin, Olivia Kates, Tara Vijayan
No abstract text is available yet for this article.
February 1, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38280271/diagnosis-and-management-of-complications-following-pelvic-organ-prolapse-surgery-using-a-synthetic-mesh-french-national-guidelines-for-clinical-practice
#13
JOURNAL ARTICLE
Xavier Deffieux, Marie-Aimée Perrouin-Verbe, Sandrine Campagne-Loiseau, Laurence Donon, Amélie Levesque, Jérome Rigaud, Nadja Stivalet, Aurélien Venara, Thibault Thubert, Adrien Vidart, Pierre-Olivier Bosset, Christine Revel-Delhom, Jean-Philippe Lucot, Jean François Hermieu
UNLABELLED: Complications associated with pelvic organ prolapse (POP) surgery using a synthetic non-absorbable mesh are uncommon (<5%) but may be severe and may hugely diminish the quality of life of some women. In drawing up these multidisciplinary clinical practice recommendations, the French National Authority for Health (Haute Autorité de santé, HAS) conducted an exhaustive review of the literature concerning the diagnosis, prevention, and management of complications associated with POP surgery using a synthetic mesh...
January 17, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38266749/engineered-peptides-harboring-cation-motifs-against-multidrug-resistant-bacteria
#14
JOURNAL ARTICLE
Lu Shang, Chan Chen, Rui Sun, Juan Guo, Jing Liu, Mi Wang, Lifang Zhang, Chenzhong Fei, Feiqun Xue, Yingchun Liu, Feng Gu
Multidrug-resistant (MDR) pathogens pose a serious threat to the health and life of humans, necessitating the development of new antimicrobial agents. Herein, we develop and characterize a panel of nine amino acid peptides with a cation end motif. Bioactivity analysis revealed that the short peptide containing "RWWWR" as a central motif harboring mirror structure "KXR" unit displayed not only high activity against MDR planktonic bacteria but also a clearance rate of 92.33% ± 0.58% against mature biofilm...
January 24, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38261237/comparative-analysis-of-outpatient-antibiotic-prescribing-in-early-life-a-population-based-study-across-birth-cohorts-in-denmark-and-germany
#15
JOURNAL ARTICLE
Oliver Scholle, Lotte Rasmussen, Mette Reilev, Jost Viebrock, Ulrike Haug
INTRODUCTION: Comparing antibiotic prescribing between countries can provide important insights into potential needs of improving antibiotic stewardship programs. We aimed to compare outpatient antibiotic prescribing in early life between children born in Denmark and Germany. METHODS: Using the Danish nationwide healthcare registries and a German claims database (GePaRD, ~ 20% population coverage), we included children born between 2004 and 2016, and followed them regarding outpatient antibiotic prescriptions until end of enrollment or the end of 2018...
January 23, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38258091/shifting-from-ammonium-to-phosphonium-salts-a-promising-strategy-to-develop-next-generation-weapons-against-biofilms
#16
REVIEW
Silvana Alfei
Since they are difficult and sometimes impossible to treat, infections sustained by multidrug-resistant (MDR) pathogens, emerging especially in nosocomial environments, are an increasing global public health concern, translating into high mortality and healthcare costs. In addition to having acquired intrinsic abilities to resist available antibiotic treatments, MDR bacteria can transmit genetic material encoding for resistance to non-mutated bacteria, thus strongly decreasing the number of available effective antibiotics...
January 5, 2024: Pharmaceutics
https://read.qxmd.com/read/38240873/micromotor-based-dual-aptassay-for-early-cost-effective-diagnosis-of-neonatal-sepsis
#17
JOURNAL ARTICLE
José M Gordón Pidal, Luis Arruza, María Moreno-Guzmán, Miguel Ángel López, Alberto Escarpa
Given the long-life expectancy of the newborn, research aimed at improving sepsis diagnosis and management in this population has been recognized as cost-effective, which at early stages continues to be a tremendous challenge. Despite there is not an ideal-specific biomarker, the simultaneous detection of biomarkers with different behavior during an infection such as procalcitonin (PCT) as high specificity biomarker with one of the earliest biomarkers in sepsis as interleukin-6 (IL-6) increases diagnostic performance...
January 19, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38212106/early-parenteral-nutrition-is-associated-with-improved-growth-in-very-low-birth-weight-infants-a-retrospective-study
#18
JOURNAL ARTICLE
René Liang Shen, Christian Ritz, Yanqi Li, Per Torp Sangild, Ping-Ping Jiang
OBJECTIVE: To assess the association between early initiation of parenteral nutrition (PN) and body growth in preterm infants with very low birth weight (VLBW). DESIGN: Causal inference analysis with confounders preselected by causal diagram based on the NeoNutriNet cohort containing data of infants born between 2011 and 2014 from 13 hospitals from 5 continents. PATIENTS: Neonates with birth weight ≤1500 g. INTERVENTIONS: PN initiated within the first day of life (early PN) versus within day 2-5 (delayed PN)...
January 11, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38211660/dalbavancin-real-life-utilization-among-diabetic-patients-suffering-from-infections-in-italy-and-spain-the-dalbadia-retrospective-cohort-study
#19
JOURNAL ARTICLE
Laura Morata Ruiz, Alessandro Ruggieri, Marco Falcone, Juan Pasquau Liaño, Ivan Gentile, Miguel Salavert Lletí, Leonor Moreno Núñez, Antonio Cascio, Carlo Tascini, Maria Bélen Loeches Yagüe, Francesco Giuseppe De Rosa, Alessandra Ori, Alessandro Comandini, Agnese Cattaneo, Paolo Antonio Grossi
OBJECTIVES: To retrospectively describe the patterns of use of dalbavancin for treating infections in diabetic patients in Italian and Spanish standard clinical practice. METHODS: DALBADIA [NCT04959799] was a multicenter, observational, retrospective cohort study, conducted in Italy and Spain. The study enrolled 97 adults with type 1 or 2 diabetes mellitus, treated with dalbavancin as per standard clinical practice for a Gram-positive bacterial infection or the Gram-positive component of a mixed infection...
January 9, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38164208/lower-extremity-necrotizing-fasciitis-with-iliopsoas-abscess-secondary-to-perforated-colon-cancer-a-diagnosis-not-to-miss
#20
Elias E Lahham, Mohammad I Alsahouri, Abdalrazeq A Ghweir, Qusai A Alsalah, Mohammad AlQadi, Nader Sarhan
Necrotizing fasciitis (NF) is a life-threatening soft tissue infection, typically caused by preexisting conditions such as trauma, complicated intraabdominal infections, or even small wounds. However, it is very rare for NF to occur as a result of perforated colon cancer (CC). Diagnosis primarily relies on clinical findings, imaging, and laboratory tests. Early diagnosis and treatment are crucial for patient survival. In this study, we present a case of an 82-year-old female a known case of CC diagnosed 1 month ago...
December 2023: Journal of Surgical Case Reports
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