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Fever AND end of life

Mary M Huerter, Jane L Meza, M Sitki Copur, Addison Tolentino, Alissa S Marr, Marsha Ketcham, Holly DeSpiegelaere, Susan Kruse, Mary E Kos, Karin Swenson, Sarah E Radniecki, Anne Kessinger, Apar Kishor Ganti
OBJECTIVE: Platinum-based doublet chemotherapy is the standard for most patients with advanced non-small cell lung cancer (NSCLC). Toxicity concerns limit chemotherapy for patients over 70years. Vinorelbine and paclitaxel are effective as single agents in advanced NSCLC. This phase II study evaluates safety and efficacy of a combination of these two agents in patients >70years with advanced NSCLC. MATERIALS AND METHODS: Patients with treatment naïve metastatic NSCLC received two cycles comprising 6 weekly doses of vinorelbine and paclitaxel, with restaging scans at week 8...
August 1, 2016: Journal of Geriatric Oncology
Gholamreza Pouladfar, Zahra Jafarpour, Amir Hossein Babaei, Bahman Pourabbas, Bita Geramizadeh, Anahita Sanaei Dashti
Visceral leishmaniasis (VL), a life-threatening parasitic infection, is endemic in the Mediterranean region. Diagnosis of VL is based on epidemiologic, clinical, and laboratory findings. However, sometimes, clinical features and laboratory findings overlap with those of autoimmune diseases. In some cases, autoantibodies are detected in patients with VL and this could be a potential diagnostic pitfall. In this study, we have reported on a three-year-old girl from a VL-endemic area in Iran, who presented with prolonged fever and splenomegaly...
2016: Case Reports in Infectious Diseases
Marijan Kovacić, Ivan Kovacić, Boris Dželalija
Descending necrotizing mediastinitis secondary to a nontraumatic retropharyngeal abscess is very rare. This form of mediastinitis in the era of potent antibiotics often ends up with lethal outcome. It usually occurs in immunocompromised patients and requires intensive multidisciplinary treatment approach. We report a case of nontraumatic retropharyngeal abscess complicated by descending necrotizing mediastinitis in a 70-year-old man with insulin dependent diabetes mellitus. The patient was admitted to our hospital after clinical and radiological diagnosis of retropharyngeal abscess...
December 2015: Acta Clinica Croatica
Soumyadeep Bhaumik, Chante Karimkhani, Christopher A Czaja, Hywel C Williams, Monica Rani, Mona Nasser, Lindsay N Boyers, Sergei Dmitruk, Robert P Dellavalle
BACKGROUND: Neglected tropical diseases (NTDs) impact disadvantaged populations in resource-scarce settings. Availability of synthesized evidence is paramount to end this disparity. The aim of the study was to determine whether NTD systematic reviews or protocols in the Cochrane Database of Systematic Reviews (CDSR) reflect disease burden. METHODS: Two authors independently searched the CDSR for reviews/protocols regarding the NTDs diseases. Each review or protocol was classified to a single NTD category...
October 2015: Journal of Family Medicine and Primary Care
Rupali Sharma, Sisira Jayathissa, Mark Weatherall
AIM: To determine the knowledge in cardiopulmonary resuscitation (CPR) process, preference for CPR, and desire to participate in end-of-life decision making amongst older hospitalised patients. METHOD: We prospectively interviewed 100 participants above 65 years of age awaiting discharge from acute medical ward and collected demographics, knowledge of CPR and opinion on CPR in various clinical scenarios. RESULTS: Amongst the participants, 58% had good understanding of all components of CPR and 91% overestimated its success...
January 8, 2016: New Zealand Medical Journal
S Trivedi, A Al-Nofal, S Kumar, S Tripathi, R J Kahoud, P J Tebben
INTRODUCTION: Zoledronic acid is an intravenous bisphosphonate used to increase bone mineral density and reduce the risk of fractures. Its safety profile compares well with pamidronate in pediatric patients. We describe an acute, severe, life-threatening, inflammatory reaction in a child. METHODS: A 7-year-old boy with complex medical problems and chronic ventilator requirements was admitted to the pediatric intensive care unit (due to ventilator needs) for zoledronic acid infusion and subsequent monitoring...
July 2016: Osteoporosis International
Cecilia P Mikita, Eduardo A Padlan
Dengue virus infection is one of the most prevalent mosquito-borne illnesses worldwide, affecting as many as 400 million persons annually. Most people experience a self-limited viral illness, but some experience life-threatening disease. Subsequent infection with other dengue virus serotypes increases the risk of development of severe dengue disease with plasma leakage with or without hemorrhage and end organ impairment. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe dengue disease, previously referred to as dengue hemorrhagic fever and dengue shock syndrome...
March 2016: Medical Hypotheses
Caitriona B O'Neill, Coral L Atoria, Eileen M O'Reilly, Martin C Henman, Peter B Bach, Elena B Elkin, Caitriona B O'Neill, Coral L Atoria, Eileen M O'Reilly, Martin C Henman, Peter B Bach, Elena B Elkin
PURPOSE: Hospital readmissions are often cited as a marker of poor quality of care. Limited data suggest some readmissions may be preventable depending upon definitions and available outpatient support. METHODS: General criteria to define preventable and not preventable admissions were developed before data collection began. The records of sequential nonsurgical oncology readmissions were reviewed independently by two reviewers. When the reviewers disagreed about assigning admissions as preventable or not preventable, a third reviewer was the tie breaker...
February 2016: Journal of Oncology Practice
Zeyan Liew, Beate Ritz, Jasveer Virk, Jørn Olsen
Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996-2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring...
September 2016: Autism Research: Official Journal of the International Society for Autism Research
Magali Teurlai, Christophe Eugène Menkès, Virgil Cavarero, Nicolas Degallier, Elodie Descloux, Jean-Paul Grangeon, Laurent Guillaumot, Thérèse Libourel, Paulo Sergio Lucio, Françoise Mathieu-Daudé, Morgan Mangeas
BACKGROUND/OBJECTIVES: Understanding the factors underlying the spatio-temporal distribution of infectious diseases provides useful information regarding their prevention and control. Dengue fever spatio-temporal patterns result from complex interactions between the virus, the host, and the vector. These interactions can be influenced by environmental conditions. Our objectives were to analyse dengue fever spatial distribution over New Caledonia during epidemic years, to identify some of the main underlying factors, and to predict the spatial evolution of dengue fever under changing climatic conditions, at the 2100 horizon...
December 2015: PLoS Neglected Tropical Diseases
Ayşe Kaçar Bayram, Mehmet Canpolat, Salih Levent Çınar, Fulya Tahan, Hakan Gumus, Sefer Kumandaş, Hüseyin Per
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, life-threatening hypersensitivity drug reaction. Patients present with cutaneous rash, fever, lymphadenopathy, hematologic abnormalities with eosinophilia and atypical lymphocytes, and visceral organ involvement. The prognosis of DRESS syndrome is related to the degree of end-organ damage, and the mortality rate is approximately 10%. CASE REPORT: We report a 9-year-old girl treated with only levetiracetam because of intracranial space occupying mass-related seizures...
February 2016: Journal of Emergency Medicine
Liliana Quaresma, Juan Gonçalves, Paula Estanqueiro, Manuel Salgado
We report an unusual case of recurrent fever, inflammatory knee pain, genu varum, persistent anemia, and high erythrocyte sedimentation rate in a 28-month-old boy as late manifestations of congenital syphilis (CS). Despite standard penicillin treatment at the end of the first month of life, it recurred later in life, more than once. In the first relapse, manifested by a likely gumma lesion, the prior penicillin treatment plus a negative venereal disease research laboratory result unduly led to exclusion of CS...
December 2015: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Katrin Thier, Bernadette Calabek, Alexander Tinchon, Wolfgang Grisold, Stefan Oberndorfer
BACKGROUND: High-grade gliomas are the most frequent primary brain tumors. Despite improvement in diagnostics and treatment, survival is still poor and quality-of-life issues are of major importance. Little is known regarding the clinical signs and symptoms of dying patients with glioblastoma. OBJECTIVE: The aim of this study was to investigate signs and symptoms as well as therapeutic strategies in patients with glioblastoma in the end-of-life phase in order to improve end-of-life care...
October 14, 2015: American Journal of Hospice & Palliative Care
Sittisede Polwiang
Background. Dengue fever is a mosquito-borne viral disease and a regular epidemic in Thailand. The peak of the dengue epidemic period is around June to August during the rainy season. It is believed that climate is an important factor for dengue transmission. Method. A mathematical model for vector-host infectious disease was used to calculate the impacts of climate to the transmission of dengue virus. In this study, the data of climate and dengue fever cases were derived from Chiang Mai during 2004-2014, Thailand...
2015: PeerJ
Daisuke Matsuda, Takeo Toshima, Toru Ikegami, Norifumi Harimoto, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Yuji Soejima, Tetsuo Ikeda, Ken Shirabe, Yoshihiko Maehara
Thrombotic microangiopathy (TMA) is a life-threatening complication after transplantation including liver transplantation, and its typical clinical picture is characterized by hemolytic anemia, thrombocytopenia, renal dysfunction, neurological abnormalities, and fever. We report the case of a 56-year-old female with end-stage liver disease who underwent living donor liver transplantation (LDLT), and whose postoperative course was characterized by renal failure and progressive hyperbilirubinemia. Two weeks after LDLT, she started to show progressive thrombocytopenia, anemia, oliguria, and encephalopathy...
April 2014: Clinical Journal of Gastroenterology
M Tuğcu, Ç Ruhi, B Boynueğri, U Kasapoğlu, Ö Can, G Kiliçoğlu, G Şahin, M Titiz
Differential diagnosis of post-transplant infections should include rare/uncommon foci and pathogens. We present a rare case of life-threatening infection, a splenic abscess in a 53-year-old woman who was transplanted with a cadaveric kidney 5 months previously. The patient was admitted to our clinic with chills, shivering, and fever. She required a kidney transplant because of end-stage renal disease secondary to systemic lupus erythematosus, which had previously been treated by means of peritoneal dialysis for 7 years, until encapsulated sclerosing peritonitis developed, at which time therapy was changed to hemodialysis for 1 year...
June 2015: Transplantation Proceedings
Veronica L Scott, Ami Patel, Daniel O Villarreal, Scott E Hensley, Edwin Ragwan, Jian Yan, Niranjan Y Sardesai, Paul J Rothwell, Jonathan P Extance, Lisa J Caproni, David B Weiner
Nucleic acid-based vaccines (NAVs) are a promising alternative to conventional influenza vaccines with the potential to increase influenza vaccine availability due to their simplicity in design and rapid speed of production. NAVs can also target multiple influenza antigens and control flu variants. Traditionally NAVs have been DNA plasmids however, we are continuing to explore new methods that may enhance vaccine efficacy. Recently new focus has been on RNA cassettes as NAVs. RNA vaccines combine conceptual advantages in that they focus on delivery of only the coding cassette...
2015: Human Vaccines & Immunotherapeutics
Larissa Mourad Ozeki, Nigel Caulkett, Gordon Stenhouse, Jon M Arnemo, Åsa Fahlman
Hyperthermia is a common complication during anesthesia of bears, and it can be life threatening. The objective of this study was to evaluate the effectiveness of active cooling on core body temperature for treatment of hyperthermia in anesthetized brown bears (Ursus arctos). In addition, body temperature after reversal with atipamezole was also evaluated. Twenty-five adult and subadult brown bears were captured with a combination of zolazepam-tiletamine and xylazine or medetomidine. A core temperature capsule was inserted into the bears' stomach or 15 cm into their rectum or a combination of both...
June 2015: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
S Monti, C Montecucco, S Pieropan, F Mojoli, A Braschi, R Caporali
OBJECTIVES: Onset of ANCA-associated vasculitis (AAV) can be abrupt with life-threatening manifestations requiring Intensive Care Unit (ICU) admission. A high level of suspicion leading to prompt diagnosis is essential. Our objective was to investigate the epidemiologic characteristics and the type of life-threatening manifestations. METHODS: Medical records of AAV patients were analysed, selecting those with an ICU onset to identify predictive signs or symptoms and past medical history warnings useful for diagnosis...
March 2015: Clinical and Experimental Rheumatology
A Buongiorno, N Pierossi
AIM: PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome is the most common autoinflammatory syndrome in pediatrics, accepted as an hyperimmune condition. Pidotimod is a molecule with immunomodulatory activity on both innate and adaptive immune responses; it also has the capacity to modulate the function of the respiratory epithelial cells through the activation of a NK-KB pathway which would involve the host-virus interaction. Moreover, the proven beneficial effect of Pidotimod in enhancing the immune response during vaccination, and its benefits in the prevention of respiratory tract infections, should be noted...
June 2015: Minerva Pediatrica
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