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Fever AND end of life

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https://www.readbyqxmd.com/read/29604992/first-description-of-the-pathogenicity-of-babesia-vogeli-in-experimentally-infected-dogs
#1
Jiawei Wang, Jilei Zhang, Patrick Kelly, Xiaofeng Zheng, Min Li, Jinfeng You, Ke Huang, Haixiang Qiu, Yaoyao Wang, Rong Zhang, Jianji Li, Junsheng Dong, Yi Feng, Jinlin Zhou, Chengming Wang
Babesiosis is a tick-borne disease that occurs worldwide with the most recognized Babesia species that infect dogs being Babesia canis, B. vogeli, B. rossi and B. gibsoni. While B. vogeli is reported in dogs worldwide, clinical and laboratory data on infections is based on reports of naturally infected dogs. To provide reliable data on the clinical and laboratory abnormalities associated with acute and more chronic infections in healthy dogs free of other tick-borne diseases, we experimentally infected dogs with a Chinese strain of B...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29546926/-perinatal-dengue-a-case-report
#2
Ramiro Manzano Núñez, James Alejandro Zapata, Herney A García-Perdomo, Diego A Gomez, Mónica A Solís Velasco
INTRODUCTION: Few reports are available about perinatal dengue, with controversial results in regards the risk of perinatal outcome. OBJECTIVE: To report a case of perinatal dengue as a differential diagno sis with neonatal sepsis, which must be considered in endemic areas. CLINICAL CASE: Male newborn of a 23 year-old female, who presented a Non-Structural Protein 1 (NS1) antigen positive to dengue at 36 weeks of gestation and negative anti-dengue antibodies...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29487752/thyroid-storm-triggered-by-strangulation-in-a-patient-with-undiagnosed-graves-disease
#3
Jorge I Conte, Marilyn A Arosemena, Kunal Kapoor, Naomi G Dempsey, Megan L Zaleski, Atil Y Kargi
Thyroid storm is the life-threatening end-organ manifestation of severe thyrotoxicosis. If left untreated, thyroid storm may cause acute heart failure, multiorgan dysfunction, and death. A high degree of suspicion is necessary to make the diagnosis and start antithyroid medications to decrease mortality. Thyroid storm is generally seen in patients with Graves' disease but should also be suspected in patients with fever, tachycardia, altered mental status, and risk factors including local trauma to the neck, such as strangulation...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29458082/beyond-pain-nurses-assessment-of-patient-suffering-dignity-and-dying-in-the-intensive-care-unit
#4
Amanda Su, Lindsay Lief, David Berlin, Zara Cooper, Daniel Ouyang, John Holmes, Renee Maciejewski, Paul K Maciejewski, Holly G Prigerson
CONTEXT: Deaths in the intensive care unit (ICU) are increasingly common in the U.S., yet little is known about patients' experiences at the end of life in the ICU. OBJECTIVES: The objective of this study was to determine nurse assessment of symptoms experienced, and care received by ICU patients in their final week, and their associations with nurse-perceived suffering and dignity. METHODS: From September 2015 to March 2017, nurses who cared for 200 ICU patients who died were interviewed about physical and psychosocial dimensions of patients' experiences...
February 17, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29454083/incidence-of-acute-suppurative-sialadenitis-in-end-stage-cancer-patients-a-retrospective-observational-study
#5
Hiroaki Watanabe, Takuya Odagiri, Yasuyuki Asai
CONTEXT: Acute suppurative sialadenitis (hereafter referred to as sialadenitis) is accompanied by pain and fever and can diminish the quality of life in end-stage cancer patients; however, its incidence is not clear. OBJECTIVES: We conducted this study to elucidate the incidence of sialadenitis in end-stage cancer patients. METHODS: Retrospective review and observational study based on patients' medical records. SUBJECTS: About 726 consecutive cancer patients who died on the palliative care unit of our hospital between April 2012 and November 2016 were included...
February 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29390302/gastrointestinal-perforation-secondary-to-accidental-ingestion-of-toothpicks-a-series-case-report
#6
Zifeng Yang, Deqing Wu, Dailan Xiong, Yong Li
RATIONALE: Toothpicks are widely used as a tooth cleaning tool after meals in China. Most of the Chinese toothpicks are made of wood or bamboo with a hard texture and sharp ends. This characteristic has proven to be potentially dangerous when toothpicks are accidentally ingested, as they can cause damage and perforation of the digestive tract and other subsequent complications. PATIENT CONCERNS: The main clinical complaints of 5 patients in this study were mainly acute or chronic abdominal pain, duration from 2 days to 2 months, 1 case with vomiting, 1 case with fever...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29123348/symptom-prevalence-in-patients-with-advanced-incurable-illness-in-bangladesh
#7
Megan Doherty, Farzana Khan, Fazle Noor Biswas, Marufa Khanom, Rubayat Rahman, Mohammad Munirul Islam Tanvir, Farhana Akter, Mridul Sarker, Nezamuddin Ahmad
Context: There is a significant need for palliative care for patients living in low- and middle-income countries. The presence and intensity of physical symptoms is a major factor influencing the suffering of patients at the end of life. Objectives: The primary aim of this study was to determine the prevalence and characteristics of common physical symptoms experienced by patients with advanced, incurable illness in a developing country. Method: This study used semi-structured interviews in patients with advanced cancer or HIV/AIDS in Bangladesh...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29061148/integrated-community-case-management-by-drug-sellers-influences-appropriate-treatment-of-paediatric-febrile-illness-in-south-western-uganda-a-quasi-experimental-study
#8
Freddy Eric Kitutu, Joan Nakayaga Kalyango, Chrispus Mayora, Katarina Ekholm Selling, Stefan Peterson, Henry Wamani
BACKGROUND: Fever case management is a major challenge for improved child health globally, despite existence of cheap and effective child survival health technologies. The integrated Community Case Management (iCCM) intervention of paediatric febrile illnesses though adopted by Uganda's Ministry of Health to be implemented by community health workers, has not addressed the inaccess to life-saving medicines and diagnostics. Therefore, the iCCM intervention was implemented in private drug shops and evaluated for its effect on appropriate treatment of paediatric fever in a low malaria transmission setting in South Western Uganda...
October 23, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28844207/a-novel-presentation-of-mycobacterium-avium-complex-in-a-recipient-of-a-lung-transplant-a-case-report
#9
Leah Cohen, Jeannette Guarner, William R Hunt
BACKGROUND: Lung transplantation remains an important potential therapeutic option for end-stage lung disease. It can improve quality of life and in some cases be a life-lengthening therapy. Despite the possible benefits, there are also many potential complications following transplantation. Here we describe a novel presentation of nontuberculous mycobacterium manifesting as an endobronchial mass developing 4 years after lung transplantation. CASE PRESENTATION: A 66-year-old African-American woman presented with progressive dyspnea, cough, and persistent wheezing of 2 months' duration...
August 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28801155/vaccinations-in-the-first-year-of-life-and-risk-of-atopic-disease-results-from-the-kiggs-study
#10
Martin Schlaud, Roma Schmitz, Christina Poethko-Müller, Ronny Kuhnert
BACKGROUND: The study focused on the question of whether and - if so - to what direction and extent immunisations in the 1st year may be associated with the risk of being diagnosed with atopic diseases after the 1st year of life. METHODS: Data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS, 2003-2006) were analysed. For analyses of potential associations between vaccination status and risk of hay fever, atopic dermatitis or asthma, sample sizes of 15254, 14297, and 15262, respectively, were available...
August 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28373007/avelumab-for-metastatic-or-locally-advanced-previously-treated-solid-tumours-javelin-solid-tumor-a-phase-1a-multicohort-dose-escalation-trial
#11
Christopher R Heery, Geraldine O'Sullivan-Coyne, Ravi A Madan, Lisa Cordes, Arun Rajan, Myrna Rauckhorst, Elizabeth Lamping, Israel Oyelakin, Jennifer L Marté, Lauren M Lepone, Renee N Donahue, Italia Grenga, Jean-Marie Cuillerot, Berend Neuteboom, Anja von Heydebreck, Kevin Chin, Jeffrey Schlom, James L Gulley
BACKGROUND: Avelumab (MSB0010718C) is a human IgG1 monoclonal antibody that binds to PD-L1, inhibiting its binding to PD-1, which inactivates T cells. We aimed to establish the safety and pharmacokinetics of avelumab in patients with solid tumours while assessing biological correlatives for future development. METHODS: This open-label, single-centre, phase 1a, dose-escalation trial (part of the JAVELIN Solid Tumor trial) assessed four doses of avelumab (1 mg/kg, 3 mg/kg, 10 mg/kg, and 20 mg/kg), with dose-level cohort expansions to provide additional safety, pharmacokinetics, and target occupancy data...
May 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28153848/cjd-mimics-and-chameleons
#12
REVIEW
Simon Mead, Peter Rudge
Rapidly progressive dementia mimicking Creutzfeldt-Jakob disease (CJD) is a relatively rare presentation but a rewarding one to become familiar with, as the potential diagnoses range from the universally fatal to the completely reversible. Patients require urgent decisions about assessment and investigation and have quickly evolving needs for treatments and support, through symptom management and end-of-life care in most cases. We have based this pragmatic review on the experiences of a specialist prion referral centre in the UK, which, unsurprisingly, is strongly biased towards seeing patients with CJD...
April 2017: Practical Neurology
https://www.readbyqxmd.com/read/27979049/medical-management-of-severe-alcoholic-hepatitis-expert-review-from-the-clinical-practice-updates-committee-of-the-aga-institute
#13
REVIEW
Mack C Mitchell, Lawrence S Friedman, Craig J McClain
The purpose of this clinical practice update is to review diagnostic criteria for severe acute alcoholic hepatitis and to determine the current best practices for this life-threatening condition. The best practices in this review are based on clinical trials, systematic reviews including meta-analysis and expert opinion to develop an approach to diagnosis and management. Best Practice Advice 1: Abstinence from drinking alcohol is the cornerstone of treatment for alcohol hepatitis (AH). Best Practice Advice 2: Patients with jaundice and suspected AH should have cultures of blood, urine, and ascites, if present, to determine the presence of bacterial infections regardless of whether they have fever...
January 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27932159/fulminant-clostridium-perfringens-sepsis-in-kidney-transplant-a-case-report
#14
P Mihaylov, J A Powelson, W C Goggins
BACKGROUND: Infections, particularly urinary tract infections, and cardiovascular accidents are the main causes of morbidity and mortality during the 1st year after kidney transplantation (KT). Bacteria and viruses, such as Escherichia coli, Enteroccoci, and Polyoma BK virus are common in the 1st 6 months, so they are controlled routinely. On the other hand, Clostridium perfringens infection is a rare life-threatening condition, associated with a high mortality rate especially in the transplant population, that is not controlled routinely...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27784885/tuberculosis
#15
REVIEW
Madhukar Pai, Marcel A Behr, David Dowdy, Keertan Dheda, Maziar Divangahi, Catharina C Boehme, Ann Ginsberg, Soumya Swaminathan, Melvin Spigelman, Haileyesus Getahun, Dick Menzies, Mario Raviglione
Tuberculosis (TB) is an airborne infectious disease caused by organisms of the Mycobacterium tuberculosis complex. Although primarily a pulmonary pathogen, M. tuberculosis can cause disease in almost any part of the body. Infection with M. tuberculosis can evolve from containment in the host, in which the bacteria are isolated within granulomas (latent TB infection), to a contagious state, in which the patient will show symptoms that can include cough, fever, night sweats and weight loss. Only active pulmonary TB is contagious...
October 27, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27491498/weekly-vinorelbine-and-paclitaxel-in-older-patients-with-advanced-non-small-cell-lung-cancer-a-phase-ii-fred-and-pamela-buffet-cancer-center-clinical-trials-network-study
#16
Mary M Huerter, Jane L Meza, M Sitki Copur, Addison Tolentino, Alissa S Marr, Marsha Ketcham, Holly DeSpiegelaere, Susan Kruse, Mary E Kos, Karin Swenson, Sarah E Radniecki, Anne Kessinger, Apar Kishor Ganti
OBJECTIVE: Platinum-based doublet chemotherapy is the standard for most patients with advanced non-small cell lung cancer (NSCLC). Toxicity concerns limit chemotherapy for patients over 70years. Vinorelbine and paclitaxel are effective as single agents in advanced NSCLC. This phase II study evaluates safety and efficacy of a combination of these two agents in patients >70years with advanced NSCLC. MATERIALS AND METHODS: Patients with treatment naïve metastatic NSCLC received two cycles comprising 6 weekly doses of vinorelbine and paclitaxel, with restaging scans at week 8...
January 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27418985/autoantibodies-in-a-three-year-old-girl-with-visceral-leishmaniasis-a-potential-diagnostic-pitfall
#17
Gholamreza Pouladfar, Zahra Jafarpour, Amir Hossein Babaei, Bahman Pourabbas, Bita Geramizadeh, Anahita Sanaei Dashti
Visceral leishmaniasis (VL), a life-threatening parasitic infection, is endemic in the Mediterranean region. Diagnosis of VL is based on epidemiologic, clinical, and laboratory findings. However, sometimes, clinical features and laboratory findings overlap with those of autoimmune diseases. In some cases, autoantibodies are detected in patients with VL and this could be a potential diagnostic pitfall. In this study, we have reported on a three-year-old girl from a VL-endemic area in Iran, who presented with prolonged fever and splenomegaly...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27017733/descending-necrotizing-mediastinitis-secondary-to-retropharyngeal-abscess
#18
Marijan Kovacić, Ivan Kovacić, Boris Dželalija
Descending necrotizing mediastinitis secondary to a nontraumatic retropharyngeal abscess is very rare. This form of mediastinitis in the era of potent antibiotics often ends up with lethal outcome. It usually occurs in immunocompromised patients and requires intensive multidisciplinary treatment approach. We report a case of nontraumatic retropharyngeal abscess complicated by descending necrotizing mediastinitis in a 70-year-old man with insulin dependent diabetes mellitus. The patient was admitted to our hospital after clinical and radiological diagnosis of retropharyngeal abscess...
December 2015: Acta Clinica Croatica
https://www.readbyqxmd.com/read/26985407/identifying-gaps-in-research-prioritization-the-global-burden-of-neglected-tropical-diseases-as-reflected-in-the-cochrane-database-of-systematic-reviews
#19
Soumyadeep Bhaumik, Chante Karimkhani, Christopher A Czaja, Hywel C Williams, Monica Rani, Mona Nasser, Lindsay N Boyers, Sergei Dmitruk, Robert P Dellavalle
BACKGROUND: Neglected tropical diseases (NTDs) impact disadvantaged populations in resource-scarce settings. Availability of synthesized evidence is paramount to end this disparity. The aim of the study was to determine whether NTD systematic reviews or protocols in the Cochrane Database of Systematic Reviews (CDSR) reflect disease burden. METHODS: Two authors independently searched the CDSR for reviews/protocols regarding the NTDs diseases. Each review or protocol was classified to a single NTD category...
October 2015: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/26914191/cardiopulmonary-resuscitation-knowledge-and-opinions-on-end-of-life-decision-making-of-older-adults-admitted-to-an-acute-medical-service
#20
Rupali Sharma, Sisira Jayathissa, Mark Weatherall
AIM: To determine the knowledge in cardiopulmonary resuscitation (CPR) process, preference for CPR, and desire to participate in end-of-life decision making amongst older hospitalised patients. METHOD: We prospectively interviewed 100 participants above 65 years of age awaiting discharge from acute medical ward and collected demographics, knowledge of CPR and opinion on CPR in various clinical scenarios. RESULTS: Amongst the participants, 58% had good understanding of all components of CPR and 91% overestimated its success...
January 8, 2016: New Zealand Medical Journal
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