Mario Alles, Manuja Gunasena, Aaren Kettelhut, Kate Ailstock, Victor Musiime, Cissy Kityo, Brian Richardson, Will Mulhern, Banumathi Tamilselvan, Michael Rubsamen, Dhanuja Kasturiratna, Thorsten Demberg, Cheryl M Cameron, Mark J Cameron, Sahera Dirajlal-Fargo, Nicholas T Funderburg, Namal P M Liyanage
Human immunodeficiency virus (HIV) is associated with persistent immune activation and dysfunction in people with HIV despite treatment with antiretroviral therapy (ART). Modulation of the immune system may be driven by: low-level HIV replication, co-pathogens, gut dysbiosis /translocation, altered lipid profiles, and ART toxicities. In addition, perinatally acquired HIV (PHIV) and lifelong ART may alter the development and function of the immune system. Our preliminary data and published literature suggest reprogramming innate immune cells may accelerate aging and increase the risk for future end-organ complications, including cardiovascular disease (CVD)...
November 7, 2023: medRxiv