keyword
https://read.qxmd.com/read/38064855/identification-of-genomic-regions-genetic-variants-and-gene-networks-regulating-candidate-genes-for-lipid-metabolism-in-pig-muscle
#21
JOURNAL ARTICLE
M Passols, F Llobet-Cabau, C Sebastià, A Castelló, J Valdés-Hernández, L Criado-Mesas, A Sánchez, J M Folch
The intramuscular fat content and fatty acid composition of porcine meat have a significant impact on its quality and nutritional value. This research aimed to investigate the expression of 45 genes involved in lipid metabolism in the longissimus dorsi muscle of three experimental pig backcrosses, with a 25% of Iberian background. To achieve this objective, we conducted an expression Genome-Wide Association Study (eGWAS) using gene expression levels in muscle measured by high-throughput real-time qPCR for 45 target genes and genotypes from the PorcineSNP60 BeadChip or Axiom Porcine Genotyping Array and 65 single nucleotide polymorphisms (SNPs) located in 20 genes genotyped by a custom-designed Taqman OpenArray in a cohort of 354 animals...
November 10, 2023: Animal
https://read.qxmd.com/read/37957143/ubc9-regulates-the-expression-of-mhc-ii-in-dendritic-cells-to-enhance-dss-induced-colitis-by-mediating-rbpj-sumoylation
#22
JOURNAL ARTICLE
Jing Zhang, Longmin Chen, Qianqian Xu, Yuan Zou, Fei Sun, Qing Zhou, Xi Luo, Yang Li, Cai Chen, Shu Zhang, Fei Xiong, Ping Yang, Shiwei Liu, Cong-Yi Wang
SUMOylation is an evolutionary conserved regulatory mechanism, in which Ubc9 is the only E2 conjugating enzyme. Previous studies demonstrated that SUMOylation is involved in multiple biological processes, but its role in dendritic cells (DCs) remains to be fully addressed. Herein in this report, we found that DCs deficient in Ubc9 protected mice from dextran sulfate sodium (DSS)-induced colitis, as evidenced by the ameliorated weight loss, colon length, and disrupted colon structure. Mechanistically, Ubc9 mediated SUMOylation of RBPJ, by which it stabilized RBPJ from ubiquitin-mediated degradation to enhance its transcriptional activity, while Ciita, a critical transcription factor, is a direct target downstream of RBPJ, which forms an enhanceosome complex to transcribe the expression of MHC II genes...
November 13, 2023: Cell Death & Disease
https://read.qxmd.com/read/37944428/il-27p28-specifically-regulates-mhc-ii-expression-in-macrophages-through-ciita
#23
JOURNAL ARTICLE
Yu Han, Xu Zhang, Qing Wang, Xiaoyue Cui, Hesuiyuan Wang, Xiang Zhang, Qian Wang, Jianbin Ji, Yuebing Wang, Shusen Wang, Xiuming Zhang, Haijin Xu, Mingqiang Qiao, Zhenzhou Wu
Antigen-presenting cells (APCs) constantly express major histocompatibility complex II (MHC II), including macrophages and dendritic cells (DCs) which deliver antigens to CD4+ T cells and play an important role in adaptive immunity. The expression of MHC II is controlled by the transcriptional coactivator CIITA. Interleukin-27 (IL-27), a newly discovered IL-12 family cytokine, is composed of p28 and EBI3 subunits. In this study, we used IL-27p28 conditional knock-out mice to investigate the regulatory effects of IL-27p28 on macrophage polarization and the expression of MHC II in macrophages...
November 1, 2023: Immunobiology
https://read.qxmd.com/read/37933915/interactome-analysis-implicates-class-ii-transactivator-ciita-in-depression-and-other-neuroinflammatory-disorders
#24
JOURNAL ARTICLE
Kishore Nagasubramanian, Krishnakant Gupta
Inappropriate inflammatory responses within the nervous system (neuroinflammation) have been implicated in several neurological conditions. Class II transactivator (CIITA), a principal regulator of the major histocompatibility complex II (MHCII), is known to play essential roles in inflammation. Hence, CIITA and its interactors could be potentially involved in multiple neurological disorders. However, the molecular mechanisms underlying CIITA-mediated neuroinflammation (NI) are yet to be understood. In this regard, we analyzed the potential involvement of CIITA and its interactome in the regulation of neuroinflammation...
November 7, 2023: International Journal of Neuroscience
https://read.qxmd.com/read/37923686/a-protein-based-prognostic-model-for-pancreatic-ductal-adenocarcinoma-construction-and-validation
#25
JOURNAL ARTICLE
Yonghao Xu, Yisu Wang, Qi Chen, Tao Yao, Junyu Qiu, Lei Ni, Hui Chen, Tingbo Liang
BACKGROUND: Probing relevant proteomic biomarkers may facilitate effective pancreatic adenocarcinoma (PDAC) diagnosis, treatment and prevention. Here, we developed a protein-based prognostic model for PDAC by using relevant proteomic biomarkers data from The Cancer Genome Atlas (TCGA). METHODS: We obtained PDAC's proteomic and clinical data from TCGA and used various analytical tools to identify differentially expressed proteins between normal and cancer tissues...
December 2023: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/37878653/abdominal-surgery-induces-long-lasting-changes-in-expression-and-binding-of-ctcf-with-impact-on-major-histocompatibility-complex-ii-transcription-in-circulating-human-monocytes
#26
JOURNAL ARTICLE
Benedikt Hermann Siegler, Jan Niklas Thon, Marc Altvater, Judith Schenz, Jan Larmann, Markus Alexander Weigand, Sebastian Weiterer
BACKGROUND: Postoperative immunosuppression has been recognized as an important driver of surgery-related morbidity and mortality. It is characterized by lymphocyte depression and impaired monocyte capability to present foreign antigens to T-cells via Major Histocompatibility Complex, Class II (MHC-II) molecules. In patients with postoperative abdominal sepsis, we previously detected a persisting differential binding of the CCCTC-Binding Factor (CTCF), a superordinate regulator of transcription, inside the MHC-II region with specific impact on human leucocyte antigen (HLA) gene expression...
2023: PloS One
https://read.qxmd.com/read/37873241/irf8-mutant-b-cell-lymphoma-evades-immunity-through-a-cd74-dependent-deregulation-of-antigen-processing-and-presentation-in-mhc-cii-complexes
#27
Zhijun Qiu, Jihane Khalife, An-Ping Lin, Purushoth Ethiraj, Carine Jaafar, Lilly Chiou, Gabriela Huelgas-Morales, Sadia Aslam, Shailee Arya, Yogesh K Gupta, Patricia L M Dahia, Ricardo C T Aguiar
In diffuse large B-cell lymphoma (DLBCL), the transcription factor IRF8 is the target of a series of potentially oncogenic events, including, chromosomal translocation, focal amplification, and super-enhancer perturbations. IRF8 is also frequently mutant in DLBCL, but how these variants contribute to lymphomagenesis is unknown. We modeled IRF8 mutations in DLBCL and found that they did not meaningfully impact cell fitness. Instead, IRF8 mutants, mapping either to the DNA-binding domain (DBD) or c-terminal tail, displayed diminished transcription activity towards CIITA, a direct IRF8 target...
October 15, 2023: bioRxiv
https://read.qxmd.com/read/37842025/case-report-a-late-and-isolated-presentation-of-meningoencephalomyelitis-uncovers-a-novel-pathogenic-variant-in-the-ciita-gene
#28
Mohammed F Alosaimi, Muddathir H Hamad, Muneera J AlShammari, Dima Z Jamjoom, Najd S Musibeeh
BACKGROUND: Bare lymphocyte syndrome type II (BLS II) is a rare form of severe combined immunodeficiency caused by mutations in the CIITA gene, which regulates major histocompatibility complex class II (MHC II) expression. OBJECTIVE: We report the case of a Saudi boy with a novel mutation in the CIITA gene who presented with acute and late meningoencephalomyelitis, resulting in severe neurodevelopmental regression. METHODS: We reviewed the patient's clinical and laboratory data obtained from medical records and performed a literature search on BLS II...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37835560/molecular-characterization-of-primary-mediastinal-large-b-cell-lymphomas
#29
JOURNAL ARTICLE
Marie Donzel, Florian Pesce, Alexis Trecourt, Razika Groussel, Emmanuel Bachy, Hervé Ghesquières, Juliette Fontaine, Nazim Benzerdjeb, Claire Mauduit, Alexandra Traverse-Glehen
Since the description of primary mediastinal large B-cell lymphoma (PMBL) as a distinct entity from diffuse large B-cell lymphomas (DLBCL), numerous studies have made it possible to improve their definition. Despite this, this differential diagnosis can be challenging in daily practice. However, in some centers, PMBL may be treated according to a particular regimen, distinct from those used in DLBCL, emphasizing the importance of accurate identification at diagnosis. This study aimed to describe the histological and molecular characteristics of PMBL to improve the accuracy of their diagnosis...
October 6, 2023: Cancers
https://read.qxmd.com/read/37818353/identification-of-il-27-as-a-novel-regulator-of-major-histocompatibility-complex-class-i-and-class-ii-expression-antigen-presentation-and-processing-in-intestinal-epithelial-cells
#30
JOURNAL ARTICLE
Julia Diegelmann, Stephan Brand
Antigen presentation via major histocompatibility complex (MHC) class I and class II receptors plays a fundamental role in T cell-mediated adaptive immunity. A dysregulation of this fine-tuned recognition might result in the development of autoimmune diseases such as inflammatory bowel diseases that are characterized by chronic relapsing inflammation of the intestinal tract and a damaged intestinal epithelial barrier. While MHCII receptors are usually expressed by professional antigen presenting cells (APC) only, there is increasing evidence that non-immune cells such as intestinal epithelial cells (IEC) might express MHCII upon stimulation with IFN-γ and thus act as non-professional APC...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37779910/comprehensive-analysis-of-cerna-network-composed-of-circrna-mirna-and-mrna-in-septic-acute-kidney-injury-patients-based-on-rna-seq
#31
JOURNAL ARTICLE
Si-Rong Ma, Qi Ma, Ya-Nan Ma, Wen-Jie Zhou
Background: Sepsis is a complex, life-threatening clinical syndrome that can cause other related diseases, such as acute kidney injury (AKI). Circular RNA (circRNA) is a type of non-coding RNA with a diverse range of functions, and it plays essential roles in miRNA sponge. CircRNA plays a huge part in the development of various diseases. CircRNA and the competing endogenous RNA (ceRNA) regulatory network are unknown factors in the onset and progression of septic AKI (SAKI). This study aimed to clarify the complex circRNA-associated regulatory mechanism of circRNAs in SAKI...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37777068/he-protec-but-he-also-attac-inflammasomes-swinging-the-sword
#32
EDITORIAL
Aila Akosua Kattner
This issue of the Biomedical Journal puts an emphasis on inflammasome subunits, the NLR protein family, and the role they play in immunity. CIITA is presented as promising tool for augmenting tumor immunogenicity. Several articles look into the involvement of NLRP3 in inflammatory bowel disease and changes of the gut microbiome, in blood glucose management, in sterile inflammation, and NLRP3's contribution to the development of hepatic encephalopathy. Furthermore, a review concerning small cell neuroendocrine carcinoma of the cervix is presented, insights are provided as to the association of knee pain and patellar malalignment, and the connection between hypoxia and sleep apnea in the case of liver injury is elucidated...
September 28, 2023: Biomedical Journal
https://read.qxmd.com/read/37722062/causal-als-genes-impact-the-mhc-class-ii-antigen-presentation-pathway
#33
JOURNAL ARTICLE
Binkai Chi, Muhammet M Öztürk, Christina L Paraggio, Claudia E Leonard, Maria E Sanita, Mahtab Dastpak, Jeremy D O'Connell, Jordan A Coady, Jiuchun Zhang, Steven P Gygi, Rodrigo Lopez-Gonzalez, Shanye Yin, Robin Reed
Mutations in RNA/DNA-binding proteins cause amyotrophic lateral sclerosis (ALS), but the underlying disease mechanisms remain unclear. Here, we report that a set of ALS-associated proteins, namely FUS, EWSR1, TAF15, and MATR3, impact the expression of genes encoding the major histocompatibility complex II (MHC II) antigen presentation pathway. Both subunits of the MHC II heterodimer, HLA-DR, are down-regulated in ALS gene knockouts/knockdown in HeLa and human microglial cells, due to loss of the MHC II transcription factor CIITA...
September 26, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37711610/mapping-the-splicing-landscape-of-the-human-immune-system
#34
JOURNAL ARTICLE
Hadas Ner-Gaon, Ronnie Peleg, Roi Gazit, Anat Reiner-Benaim, Tal Shay
Most human genes code for more than one transcript. Different ratios of transcripts of the same gene can be found in different cell types or states, indicating differential use of transcription start sites or differential splicing. Such differential transcript use (DTUs) events provide an additional layer of regulation and protein diversity. With the exceptions of PTPRC and CIITA, there are very few reported cases of DTU events in the immune system. To rigorously map DTUs between different human immune cell types, we leveraged four publicly available RNA sequencing datasets...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37695525/interleukin-22-suppresses-major-histocompatibility-complex-ii-in-mucosal-epithelial-cells
#35
JOURNAL ARTICLE
Md Moniruzzaman, M Arifur Rahman, Ran Wang, Kuan Yau Wong, Alice C-H Chen, Alexandra Mueller, Steven Taylor, Alexa Harding, Thishan Illankoon, Percival Wiid, Haressh Sajiir, Veronika Schreiber, Lucy D Burr, Michael A McGuckin, Simon Phipps, Sumaira Z Hasnain
Major histocompatibility complex (MHC) II is dynamically expressed on mucosal epithelial cells and is induced in response to inflammation and parasitic infections, upon exposure to microbiota, and is increased in chronic inflammatory diseases. However, the regulation of epithelial cell-specific MHC II during homeostasis is yet to be explored. We discovered a novel role for IL-22 in suppressing epithelial cell MHC II partially via the regulation of endoplasmic reticulum (ER) stress, using animals lacking the interleukin-22-receptor (IL-22RA1), primary human and murine intestinal and respiratory organoids, and murine models of respiratory virus infection or with intestinal epithelial cell defects...
November 6, 2023: Journal of Experimental Medicine
https://read.qxmd.com/read/37680464/unveiling-the-immunomodulatory-shift-epithelial-mesenchymal-transition-alters-immune-mechanisms-of-amniotic-epithelial-cells
#36
JOURNAL ARTICLE
Valeria Di Lollo, Angelo Canciello, Alessia Peserico, Massimiliano Orsini, Valentina Russo, Adrián Cerveró-Varona, Beatrice Dufrusine, Mohammad El Khatib, Valentina Curini, Annunziata Mauro, Paolo Berardinelli, Cathy Tournier, Massimo Ancora, Cesare Cammà, Enrico Dainese, Luana Fiorella Mincarelli, Barbara Barboni
Epithelial-mesenchymal transition (EMT) changes cell phenotype by affecting immune properties of amniotic epithelial cells (AECs). The present study shows how the response to lipopolysaccharide of cells collected pre- (eAECs) and post-EMT (mAECs) induces changes in their transcriptomics profile. In fact, eAECs mainly upregulate genes involved in antigen-presenting response, whereas mAECs over-express soluble inflammatory mediator transcripts. Consistently, network analysis identifies CIITA and Nrf2 as main drivers of eAECs and mAECs immune response, respectively...
September 15, 2023: IScience
https://read.qxmd.com/read/37674579/diagnosis-of-mixed-infection-and-a-primary-immunodeficiency-disease-using-next-generation-sequencing-a-case-report
#37
Xiaolei Zhang, Yixue Wang, Daly Pen, Jing Liu, Qinhua Zhou, Yao Wang, Huaqing Zhong, Tingyan Liu, Weiming Chen, Bingbing Wu, Yang Zhou, Chuanqing Wang, Xiangyu Li, Fangyou Yu, Xiaochuan Wang, Guoping Lu, Gangfeng Yan
Major Histocompatibility Complex Class II (MHC II) deficiency is a rare primary immunodeficiency disorder (PID) with autosomal recessive inheritance pattern. The outcome is almost fatal owing to delayed diagnosis and lacking of effective therapy. Therefore, prompt diagnosis, timely and effective treatment are critical. Here, we report a 117-day-old boy with diarrhea, cough, cyanosis and tachypnea who was failed to be cured by empiric antimicrobial therapy initially and progressed to severe pneumonia and respiratory failure...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37604847/the-non-classical-major-histocompatibility-complex-ii-protein-sla-dm-is-crucial-for-african-swine-fever-virus-replication
#38
JOURNAL ARTICLE
Katrin Pannhorst, Jolene Carlson, Julia E Hölper, Finn Grey, John Kenneth Baillie, Dirk Höper, Elisabeth Wöhnke, Kati Franzke, Axel Karger, Walter Fuchs, Thomas C Mettenleiter
African swine fever virus (ASFV) is a lethal animal pathogen that enters its host cells through endocytosis. So far, host factors specifically required for ASFV replication have been barely identified. In this study a genome-wide CRISPR/Cas9 knockout screen in porcine cells indicated that the genes RFXANK, RFXAP, SLA-DMA, SLA-DMB, and CIITA are important for productive ASFV infection. The proteins encoded by these genes belong to the major histocompatibility complex II (MHC II), or swine leucocyte antigen complex II (SLA II)...
August 21, 2023: Scientific Reports
https://read.qxmd.com/read/37565053/mhc-class-ii-is-induced-by-ifn%C3%AE-and-follows-three-distinct-patterns-of-expression-in-colorectal-cancer-organoids
#39
JOURNAL ARTICLE
Oliver J Pickles, Kasun Wanigasooriya, Anetta Ptasinska, Akshay J Patel, Helen L Robbins, Claire Bryer, Celina M Whalley, Louise Tee, Neeraj Lal, Claudia M A Pinna, Nahla Elzefzafy, Philippe Taniere, Andrew D Beggs, Gary M Middleton
UNLABELLED: Tumor-specific MHC class II (tsMHC-II) expression impacts tumor microenvironmental immunity. tsMHC-II positive cancer cells may act as surrogate antigen-presenting cells and targets for CD4+ T cell-mediated lysis. In colorectal cancer, tsMHC-II negativity is common, in cell lines due to CIITA promoter methylation. To clarify mechanisms of tsMHC-II repression in colorectal cancer, we analyzed colorectal cancer organoids which are epigenetically faithful to tissue of origin...
August 2023: Cancer Res Commun
https://read.qxmd.com/read/37511568/hypoimmunogenic-human-pluripotent-stem-cells-as-a-powerful-tool-for-liver-regenerative-medicine
#40
JOURNAL ARTICLE
Piera Trionfini, Elena Romano, Marco Varinelli, Lorena Longaretti, Paola Rizzo, Roberta Giampietro, Annalina Caroli, Sistiana Aiello, Marta Todeschini, Federica Casiraghi, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni
Induced pluripotent stem cells (iPSC) have huge potential as cell therapy for various diseases, given their potential for unlimited self-renewal and capability to differentiate into a wide range of cell types. Although autologous iPSCs represents the ideal source for patient-tailored regenerative medicine, the high costs of the extensive and time-consuming production process and the impracticability for treating acute conditions hinder their use for broad applications. An allogeneic iPSC-based strategy may overcome these issues, but it carries the risk of triggering an immune response...
July 22, 2023: International Journal of Molecular Sciences
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