Daphne Dupéré-Richer, Alberto Riva, Sayantan Maji, Benjamin G Barwick, Heidi Casellas Román, Amin Sobh, Gabrielle Quickstad, Jianping Li, Umasankar De, Crissandra Piper, Marta Kulis, Teresa Ezponda, José Ignacio Martin-Subero, Giovanni Tonon, Weizhou Zhang, Constantine S Mitsiades, Lawrence H Boise, Richard L Bennett, Jonathan D Licht
UNLABELLED: The histone H3K27 demethylase KDM6A is a tumor suppressor in multiple cancers, including multiple myeloma (MM). We created isogenic MM cells disrupted for KDM6A and tagged the endogenous protein to facilitate genome wide studies. KDM6A binds genes associated with immune recognition and cytokine signaling. Most importantly, KDM6A binds and activates NLRC5 and CIITA encoding regulators of Major Histocompatibility Complex (MHC) genes. Patient data indicate that NLRC5 and CIITA, are downregulated in MM with low KDM6A expression...
February 12, 2024: bioRxiv