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Tnm staging head neck tumors

Ji-Hoon Jung, Sang-Woo Lee, Seung Hyun Son, Choon-Young Kim, Chang-Hee Lee, Ju Hye Jeong, Shin Young Jeong, Byeong-Cheol Ahn, Jaetae Lee
BACKGROUND: The purpose of this retrospective study was to assess the diagnostic value of (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the prognostic value of metabolic PET parameters in patients with adenoid cystic carcinoma of the head and neck (ACCHN). METHODS: Forty patients with newly diagnosed ACCHN were enrolled in this study. We investigated the diagnostic value of (18) F-FDG PET/CT for detecting and staging compared to conventional CT...
October 11, 2016: Head & Neck
Jian Gao, Camilla H Ulekleiv, Trond S Halstensen
BACKGROUND: Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcinoma (HNSCC) is unclear. Our aim was to clarify whether mRNA expression of EGFR-ligands was linked to prognosis and cisplatin resistance, and if so, which ligand was most important and how was the expression regulated. METHODS: To examine the prognostic effect of EGFR-ligand expression, we analyzed tumorous mRNA expression in 399 HNSCC patients...
September 26, 2016: Journal of Experimental & Clinical Cancer Research: CR
Lili Bao, Hao Liu, Bo You, Miao Gu, Si Shi, Ying Shan, Li Li, Jing Chen, Yiwen You
Insulin-like growth factor-binding protein-3 (IGFBP3) is an N-linked glycosylated, phosphorylated protein, which has been reported to regulate cancer progression and metastasis. However, the role of IGFBP3 in tumor metastasis remains under debate. Nasopharyngeal carcinoma (NPC) is a highly metastatic head and neck cancer. And it fails to achieve the desired therapeutic efficacy in patients with metastasis, while the role of IGFBP3 in NPC is still unclear. In this study, we first used immunohistochemistry to explore the expression of IGFBP3 in NPC tissues...
September 22, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
M de Ridder, C C M Marres, L E Smeele, M W M van den Brekel, M Hauptmann, A J M Balm, M L F van Velthuysen
In head and neck squamous cell carcinoma (HNSCC), the search for better prognostic factors beyond TNM-stage is ongoing. Lymph node ratio (LNR) (positive lymph nodes/total lymph nodes) is gaining interest in view of its potential prognostic significance. All HNSCC patients at the Netherlands Cancer Institute undergoing neck dissection for lymph node metastases in the neck region between 2002 and 2012 (n = 176) were included. Based on a protocol change in specimen processing, the cohort was subdivided in two distinct consecutive periods (pre and post 2007)...
September 18, 2016: Virchows Archiv: An International Journal of Pathology
Bianca Rivera-Peña, Francisco J Ruíz-Fullana, Germán L Vélez-Reyes, Rosa J Rodriguez-Benitez, María J Marcos-Martínez, Juan Trinidad-Pinedo, Adriana Báez
BACKGROUND: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. METHODS: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x(2)...
2016: Infectious Agents and Cancer
Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt, Gilles Dolivet
BACKGROUND: Despite aggressive regimens, the clinical outcome of head and neck squamous cell carcinoma remains poor. The detection of circulating tumor cells could potentially improve the management of patients with disseminated cancer, including diagnosis, treatment strategies, and surveillance. Currently, CellSearch(®) is the most widely used and the only Food and Drug Administration-cleared system for circulating tumor cells detection in patients with metastatic breast, colorectal, or prostate cancer...
2016: BMC Cancer
Jun Ju, Jia Wang, Chao Ma, Yun Li, Zhenyan Zhao, Tao Gao, Qianwei Ni, Moyi Sun
This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. An external dataset of 219 patients was used to validate the nomograms. Of 36,179 HNSCC patients, 9,627 (26.6%) died from HNSCC and 4,229 (11...
July 13, 2016: Oncotarget
Jon Cacicedo, Arturo Navarro, Olga Del Hoyo, Alfonso Gomez-Iturriaga, Filippo Alongi, Jose Antonio Medina, Olgun Elicin, Andrea Skanjeti, Francesco Giammarile, Pedro Bilbao, Francisco Casquero, Berardino de Bari, Alan Dal Pra
Squamous cell carcinoma (SCC) is the most common malignant tumor of the head and neck (HN). The initial TNM staging, the evaluation of the tumor response during treatment and the long-term surveillance are crucial moments in the approach to HNSCC. Thus, at each of these moments, the choice of the best diagnostic tool providing the more precise and larger information is crucial. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (FDG-PET/CT) rapidly gained clinical acceptance, and it has become an important imaging tool in routine clinical oncology...
July 15, 2016: British Journal of Radiology
Feng Li, Juying Liu, Dan Song, Qian Zhang, Naixin Ding, Xia He
CONCLUSION: The results implied that CTCs were common even in early TNM stages and might become a potential parameter in evaluating therapeutic effects of radio and chemotherapies. BACKGROUND: Nasopharyngeal carcinoma (NPC) is a head and neck malignancy with an extraordinary high incidence in Southern China and a high metastasis rate. Analysis of circulating tumor cells (CTCs) in peripheral blood is a relatively new prognostic marker for cancer patients. PATIENTS AND METHODS: This retrospective study included data from 38 nasopharyngeal patients with poorly differentiated squamous cell carcinoma in TNM stage I (n = 2), TNM stage II (n = 12), TNM stage III (n = 8), and TNM stage IV (n = 16)...
July 7, 2016: Acta Oto-laryngologica
Bin Yang, Lin Jia, Qiaojuan Guo, Hui Ren, Yanping Hu, Tao Xie
Several studies have assessed the clinicopathological and prognostic value of cyclooxygenase-2 (COX-2) expression in patients with head and neck cancer (HNC), but their results remain controversial. To address this issue, a meta-analysis was carried out. A total of 29 studies involving 2430 patients were subjected to final analysis. Our results indicated that COX-2 expression was not statistically associated with advanced tumor stage (OR, 1.23; 95% CI, 0.98-1.55) but correlated with high risk of lymph node metastasis (OR, 1...
June 15, 2016: Oncotarget
Nader Sadeghi, Ning-Wei Li, M Reza Taheri, Samantha Easley, Robert S Siegel
BACKGROUND: The purpose of this study was to present our evaluation of the outcome of oropharyngeal cancer managed with neoadjuvant chemotherapy and transoral surgery (TOS) with neck dissection as definitive treatment. METHODS: This is a case series of 17 patients with advanced oropharyngeal cancer who were treated with neoadjuvant chemotherapy followed by TOS. The treatment details and oncologic outcome are reported. The volumetric response of the tumor to neoadjuvant chemotherapy is evaluated and validated by histopathology...
June 14, 2016: Head & Neck
Aris I Giotakis, Christos K Kontos, Leonidas D Manolopoulos, Aristides Sismanis, Manousos M Konstadoulakis, Andreas Scorilas
OBJECTIVES: Laryngeal squamous cell carcinoma (LSCC), a common type of head and neck cancer, is associated with high rates of metastasis and recurrence. Therefore, accurate prognostic stratification of LSCC patients based on molecular prognostic tumor biomarkers would definitely lead to a better clinical management of this malignancy. The aim of this study was the investigation of the potential combinatorial prognostic value of BCL2 and BAX mRNA expression in LSCC. DESIGN AND METHODS: Total RNA was isolated from 105 cancerous laryngeal tissue specimens obtained from patients having undergone surgical treatment for primary LSCC...
August 2016: Clinical Biochemistry
Eniko Reka Fejer, Zoltan Abram, Jiahe Zs Egyed, Septimiu Voidazan, Erika Toth, Zoltan Szentirmay, Miklos Kasler
PURPOSE: Many patients with oropharyngeal squamous cell carcinomas do not have any of the traditional risk factors associated with head and neck squamous cell cancers (HNSCC). Epidemiologic and molecular studies have identified human papillomavirus (HPV) as a causative agent, viral tumors presenting a better survival and being important risk factors together with the long established ones, tobacco and alcohol consumption, in head and neck cancers. The purpose of this study was to establish the incidence of HPV-associated HNSCCs, to identify the most frequent HPV type and to evaluate the overall survival and recurrence rates of HPV-positive cases in comparison with HPV-negative HNSCCs...
January 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
B Ko, U Parvathaneni, P A Hudgins, Y Anzai
BACKGROUND AND PURPOSE: CT and MR imaging are widely used for the staging of head and neck cancer. Currently, there are no data regarding whether the primary tumor, nodes, metastasis (TNM) staging is routinely incorporated into radiology reports. We conducted a national survey to determine whether radiologists routinely address staging, in particular regarding T (primary tumor) and N (nodal). MATERIALS AND METHODS: The survey was sent to 782 members of the American Society of Head and Neck Radiology...
August 2016: AJNR. American Journal of Neuroradiology
Karan Gupta, Naresh K Panda, Jaimanti Bakshi, Ashim Das
BACKGROUND: Accurate clinical staging is important for patient counseling, treatment planning, prognostication, and rational design of clinical trials. In head and neck squamous cell carcinoma, discrepancy between clinical and pathological staging has been reported. OBJECTIVE: To evaluate any disparity between clinical and pathological tumor-node-metastasis (TNM) staging in oral cavity squamous cell carcinoma (OCSCC) patients and any impact of the same on survival...
October 2015: South Asian Journal of Cancer
Éder Ricardo Biasoli, Vitor Bonetti Valente, Bruna Mantovan, Francisco Urbano Collado, Sebastião Conrado Neto, Maria Lúcia Marçal Mazza Sundefeld, Glauco Issamu Miyahara, Daniel Galera Bernabé
PURPOSE: There are few clinical studies focusing on treatment outcomes of lip cancer. This study investigated the clinicopathologic variables of a large sample of patients with lip squamous cell carcinoma (LSCC) treated in a reference head and neck cancer center for the past 25 years and analyzed the influence of these variables on treatment outcomes. MATERIALS AND METHODS: This retrospective cohort study reviewed the clinical records of patients with LSCC. Epidemiologic data were age, gender, ethnicity, type of occupation, tobacco smoking, alcohol consumption, comorbid conditions, and family cancer history...
July 2016: Journal of Oral and Maxillofacial Surgery
Atsumu Kouketsu, Ikuro Sato, Satoko Abe, Mariko Oikawa, Yoshinaka Shimizu, Tetsu Takahashi, Hiroyuki Kumamoto
OBJECTIVE: Recent evidence suggests that human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a separate HNSCC subgroup with distinct epidemiology, histopathological characteristics, therapeutic response to chemotherapy and radiation, and clinical outcome. This study aimed to investigate the role of HPV infection in oral squamous cell carcinoma (OSCC) and the correlation between HPV infection, tumor suppressor protein p16 expression, and clinicopathological features in Japanese patients...
September 2016: Journal of Oral Pathology & Medicine
Kara S Davis, Chwee Ming Lim, David A Clump, Dwight E Heron, James P Ohr, Seungwon Kim, Umamaheswar Duvvuri, Jonas T Johnson, Robert L Ferris
BACKGROUND: Increasing evidence exists that tumor volume may be a superior prognostic model than traditional TNM staging. It has been observed that oropharyngeal squamous cell carcinoma (oropharyngeal SCC) in the setting of human papillomavirus (HPV) positivity have a greater propensity for cystic nodal metastases, and, thus, presumably larger volume with relatively smaller primary tumors. The influence of HPV status on the predictive value of tumor volume is unknown. METHODS: Fifty-three patients with HPV-positive oropharyngeal SCC were treated with definitive chemotherapy and intensity-modulated radiotherapy (IMRT)...
April 2016: Head & Neck
N Dulguerov, F Caparrotti, N Mach, P Dulguerov
We compared the treatment modalities as well as the oncologic outcome between young elderly (65-79 years old), elderly (>80 years old) and the reference population (<65 years old.) We reviewed 1047 patients treated between 2002 and 2012. Tumor sites, TNM stages, type of treatment, and the oncologic results are compared with survival statistics. The elderly group was associated with an increase in palliative treatment, more women and advanced T stages. For the 947 patients treated with curative intent, 5 year recurrence free survival was comparable...
September 30, 2015: Revue Médicale Suisse
Lei Wang, Chen Chen, Fen Li, Qingquan Hua, Shiming Chen, Bokui Xiao, Mengyuan Dai, Man Li, Anyuan Zheng, Di Yu, Zhangwei Hu, Zezhang Tao
To examine the significance of the Neutrophil gelatinase-associated lipocalin (NGAL) in diagnosing head and neck squamous cell carcinoma (HNSCC) and predicting regional metastasis. We first used GEO dataset to analyze the NGAL gene expression in HNSCC. Then, we summarized the characteristics of patients retrospectively selected in clinic. Expression of NGAL protein in human HNSCC tumor, lymph node and normal samples were analyzed using immunohistochemistry. Next, we further investigated the NGAL expression in a tissue microassay to analyze the relationship between NGAL protein expression and TNM stage...
2015: International Journal of Clinical and Experimental Pathology
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