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Tnm staging head neck tumors

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https://www.readbyqxmd.com/read/28128848/head-and-neck-cancers-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#1
William M Lydiatt, Snehal G Patel, Brian O'Sullivan, Margaret S Brandwein, John A Ridge, Jocelyn C Migliacci, Ashley M Loomis, Jatin P Shah
Answer questions and earn CME/CNE The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes...
March 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28119088/lncrna-tug1-regulates-the-oral-squamous-cell-carcinoma-progression-possibly-via-interacting-with-wnt-%C3%AE-catenin-signaling
#2
Shuang Liang, Songzi Zhang, Peng Wang, Chao Yang, Chen Shang, Jianjun Yang, Jun Wang
Oral squamous cell carcinoma (OSCC) is one the most common cancer affecting the head and neck region, and the molecular mechanisms underlying OSCC development is largely unknown. Long non-coding RNAs (lncRNAs) are emerging as key regulators in tumor development. The present study aimed to investigate the role of lncRNA, taurine upregulated gene 1 (TUG1) in OSCC development. The mRNA and protein expression levels were determined by qRT-PCR and western blotting; flow cytometry and ELISA experiments were employed to examine the cell apoptosis; CCK-8 assay, MTT assay, colony formation assay, and cell invasion assay was used to determine cell growth, cell proliferation and cell invasion, respectively...
April 15, 2017: Gene
https://www.readbyqxmd.com/read/27928453/impact-of-gender-and-primary-tumor-location-on-outcome-of-patients-with-cutaneous-melanoma
#3
S Voinea, A Blidaru, E Panaitescu, A Sandru
Background. The survival of patients with cutaneous malignant melanoma (MM) depends on multiple factors whose role is continuously updated, as the molecular mechanisms underlying the disease progression are understood. This study intended to assess whether the patient's gender and tumor location affect the disease outcome. Methods. Between 2008 and 2012, 155 patients with cutaneous MM underwent various types of surgeries in our clinic. Patients were staged according to the 2009 TNM classification. There were 90 women and 65 men...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27796149/trends-in-incidence-and-survival-of-cutaneous-malignant-melanoma-in-estonia-a-population-based-study
#4
Peeter Padrik, Ann Valter, Epp Valter, Aleksei Baburin, Kaire Innos
BACKGROUND: Previous studies have shown an increase in the incidence of cutaneous melanoma (CM) in Estonia, but also poor survival in international comparisons, with a significant survival gap between the sexes. The aim of this study was to analyze the time trends in CM incidence and relative survival by age, TNM stage and anatomical subsite among men and women in Estonia. MATERIALS AND METHODS: Data from the Estonian Cancer Registry were used to calculate age-standardized (World) and age-specific incidence of CM in 1995-2013, and five-year relative survival ratios (RSR) for cases diagnosed in 1995-2012 and followed through in 2014...
January 2017: Acta Oncologica
https://www.readbyqxmd.com/read/27726225/clinical-impact-of-18-f-fdg-positron-emission-tomography-ct-on-adenoid-cystic-carcinoma-of-the-head-and-neck
#5
Ji-Hoon Jung, Sang-Woo Lee, Seung Hyun Son, Choon-Young Kim, Chang-Hee Lee, Ju Hye Jeong, Shin Young Jeong, Byeong-Cheol Ahn, Jaetae Lee
BACKGROUND: The purpose of this retrospective study was to assess the diagnostic value of (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the prognostic value of metabolic PET parameters in patients with adenoid cystic carcinoma of the head and neck (ACCHN). METHODS: Forty patients with newly diagnosed ACCHN were enrolled in this study. We investigated the diagnostic value of (18) F-FDG PET/CT for detecting and staging compared to conventional CT...
October 11, 2016: Head & Neck
https://www.readbyqxmd.com/read/27669890/epidermal-growth-factor-egf-receptor-ligand-based-molecular-staging-predicts-prognosis-in-head-and-neck-squamous-cell-carcinoma-partly-due-to-deregulated-egf-induced-amphiregulin-expression
#6
Jian Gao, Camilla H Ulekleiv, Trond S Halstensen
BACKGROUND: Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcinoma (HNSCC) is unclear. Our aim was to clarify whether mRNA expression of EGFR-ligands was linked to prognosis and cisplatin resistance, and if so, which ligand was most important and how was the expression regulated. METHODS: To examine the prognostic effect of EGFR-ligand expression, we analyzed tumorous mRNA expression in 399 HNSCC patients...
September 26, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27658775/overexpression-of-igfbp3-is-associated-with-poor-prognosis-and-tumor-metastasis-in-nasopharyngeal-carcinoma
#7
Lili Bao, Hao Liu, Bo You, Miao Gu, Si Shi, Ying Shan, Li Li, Jing Chen, Yiwen You
Insulin-like growth factor-binding protein-3 (IGFBP3) is an N-linked glycosylated, phosphorylated protein, which has been reported to regulate cancer progression and metastasis. However, the role of IGFBP3 in tumor metastasis remains under debate. Nasopharyngeal carcinoma (NPC) is a highly metastatic head and neck cancer. And it fails to achieve the desired therapeutic efficacy in patients with metastasis, while the role of IGFBP3 in NPC is still unclear. In this study, we first used immunohistochemistry to explore the expression of IGFBP3 in NPC tissues...
November 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27639568/a-critical-evaluation-of-lymph-node-ratio-in-head-and-neck-cancer
#8
M de Ridder, C C M Marres, L E Smeele, M W M van den Brekel, M Hauptmann, A J M Balm, M L F van Velthuysen
In head and neck squamous cell carcinoma (HNSCC), the search for better prognostic factors beyond TNM-stage is ongoing. Lymph node ratio (LNR) (positive lymph nodes/total lymph nodes) is gaining interest in view of its potential prognostic significance. All HNSCC patients at the Netherlands Cancer Institute undergoing neck dissection for lymph node metastases in the neck region between 2002 and 2012 (n = 176) were included. Based on a protocol change in specimen processing, the cohort was subdivided in two distinct consecutive periods (pre and post 2007)...
December 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27559359/hpv-16-infection-modifies-overall-survival-of-puerto-rican-hnscc-patients
#9
Bianca Rivera-Peña, Francisco J Ruíz-Fullana, Germán L Vélez-Reyes, Rosa J Rodriguez-Benitez, María J Marcos-Martínez, Juan Trinidad-Pinedo, Adriana Báez
BACKGROUND: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. METHODS: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x(2)...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27465596/a-rare-case-of-extremely-high-counts-of-circulating-tumor-cells-detected-in-a-patient-with-an-oral-squamous-cell-carcinoma
#10
Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt, Gilles Dolivet
BACKGROUND: Despite aggressive regimens, the clinical outcome of head and neck squamous cell carcinoma remains poor. The detection of circulating tumor cells could potentially improve the management of patients with disseminated cancer, including diagnosis, treatment strategies, and surveillance. Currently, CellSearch(®) is the most widely used and the only Food and Drug Administration-cleared system for circulating tumor cells detection in patients with metastatic breast, colorectal, or prostate cancer...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27419636/nomograms-predicting-long-term-overall-survival-and-cancer-specific-survival-in-head-and-neck-squamous-cell-carcinoma-patients
#11
Jun Ju, Jia Wang, Chao Ma, Yun Li, Zhenyan Zhao, Tao Gao, Qianwei Ni, Moyi Sun
This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. An external dataset of 219 patients was used to validate the nomograms. Of 36,179 HNSCC patients, 9,627 (26.6%) died from HNSCC and 4,229 (11...
August 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27416996/role-of-fluorine-18-fluorodeoxyglucose-pet-ct-in-head-and-neck-oncology-the-point-of-view-of-the-radiation-oncologist
#12
REVIEW
Jon Cacicedo, Arturo Navarro, Olga Del Hoyo, Alfonso Gomez-Iturriaga, Filippo Alongi, Jose A Medina, Olgun Elicin, Andrea Skanjeti, Francesco Giammarile, Pedro Bilbao, Francisco Casquero, Berardino de Bari, Alan Dal Pra
Squamous cell carcinoma is the most common malignant tumour of the head and neck. The initial TNM staging, the evaluation of the tumour response during treatment, and the long-term surveillance are crucial moments in the approach to head and neck squamous cell carcinoma (HNSCC). Thus, at each of these moments, the choice of the best diagnostic tool providing the more precise and larger information is crucial. Positron emission tomography with fluorine-18 fludeoxyglucose integrated with CT ((18)F-FDG-PET/CT) rapidly gained clinical acceptance, and it has become an important imaging tool in routine clinical oncology...
November 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27387761/circulating-tumor-cells-in-the-blood-of-poorly-differentiated-nasal-squamous-cell-carcinoma-patients-correlation-with-treatment-response
#13
Feng Li, Juying Liu, Dan Song, Qian Zhang, Naixin Ding, Xia He
CONCLUSION: The results implied that CTCs were common even in early TNM stages and might become a potential parameter in evaluating therapeutic effects of radio and chemotherapies. BACKGROUND: Nasopharyngeal carcinoma (NPC) is a head and neck malignancy with an extraordinary high incidence in Southern China and a high metastasis rate. Analysis of circulating tumor cells (CTCs) in peripheral blood is a relatively new prognostic marker for cancer patients. PATIENTS AND METHODS: This retrospective study included data from 38 nasopharyngeal patients with poorly differentiated squamous cell carcinoma in TNM stage I (n = 2), TNM stage II (n = 12), TNM stage III (n = 8), and TNM stage IV (n = 16)...
November 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27323811/clinicopathological-and-prognostic-significance-of-cyclooxygenase-2-expression-in-head-and-neck-cancer-a-meta-analysis
#14
Bin Yang, Lin Jia, Qiaojuan Guo, Hui Ren, Yanping Hu, Tao Xie
Several studies have assessed the clinicopathological and prognostic value of cyclooxygenase-2 (COX-2) expression in patients with head and neck cancer (HNC), but their results remain controversial. To address this issue, a meta-analysis was carried out. A total of 29 studies involving 2430 patients were subjected to final analysis. Our results indicated that COX-2 expression was not statistically associated with advanced tumor stage (OR, 1.23; 95% CI, 0.98-1.55) but correlated with high risk of lymph node metastasis (OR, 1...
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27299983/neoadjuvant-chemotherapy-and-transoral-surgery-as-a-definitive-treatment-for-oropharyngeal-cancer-a-feasible-novel-approach
#15
Nader Sadeghi, Ning-Wei Li, M Reza Taheri, Samantha Easley, Robert S Siegel
BACKGROUND: The purpose of this study was to present our evaluation of the outcome of oropharyngeal cancer managed with neoadjuvant chemotherapy and transoral surgery (TOS) with neck dissection as definitive treatment. METHODS: This is a case series of 17 patients with advanced oropharyngeal cancer who were treated with neoadjuvant chemotherapy followed by TOS. The treatment details and oncologic outcome are reported. The volumetric response of the tumor to neoadjuvant chemotherapy is evaluated and validated by histopathology...
December 2016: Head & Neck
https://www.readbyqxmd.com/read/27129795/high-bax-bcl2-mrna-ratio-predicts-favorable-prognosis-in-laryngeal-squamous-cell-carcinoma-particularly-in-patients-with-negative-lymph-nodes-at-the-time-of-diagnosis
#16
Aris I Giotakis, Christos K Kontos, Leonidas D Manolopoulos, Aristides Sismanis, Manousos M Konstadoulakis, Andreas Scorilas
OBJECTIVES: Laryngeal squamous cell carcinoma (LSCC), a common type of head and neck cancer, is associated with high rates of metastasis and recurrence. Therefore, accurate prognostic stratification of LSCC patients based on molecular prognostic tumor biomarkers would definitely lead to a better clinical management of this malignancy. The aim of this study was the investigation of the potential combinatorial prognostic value of BCL2 and BAX mRNA expression in LSCC. DESIGN AND METHODS: Total RNA was isolated from 105 cancerous laryngeal tissue specimens obtained from patients having undergone surgical treatment for primary LSCC...
August 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27061545/human-papilloma-virus-status-evaluation-and-survival-description-in-selected-oropharyngeal-and-laryngeal-squamous-cell-carcinoma-patients-from-hungary
#17
Eniko Reka Fejer, Zoltan Abram, Jiahe Zs Egyed, Septimiu Voidazan, Erika Toth, Zoltan Szentirmay, Miklos Kasler
PURPOSE: Many patients with oropharyngeal squamous cell carcinomas do not have any of the traditional risk factors associated with head and neck squamous cell cancers (HNSCC). Epidemiologic and molecular studies have identified human papillomavirus (HPV) as a causative agent, viral tumors presenting a better survival and being important risk factors together with the long established ones, tobacco and alcohol consumption, in head and neck cancers. The purpose of this study was to establish the incidence of HPV-associated HNSCCs, to identify the most frequent HPV type and to evaluate the overall survival and recurrence rates of HPV-positive cases in comparison with HPV-negative HNSCCs...
January 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27032970/do-radiologists-report-the-tnm-staging-in-radiology-reports-for-head-and-neck-cancers-a-national-survey-study
#18
B Ko, U Parvathaneni, P A Hudgins, Y Anzai
BACKGROUND AND PURPOSE: CT and MR imaging are widely used for the staging of head and neck cancer. Currently, there are no data regarding whether the primary tumor, nodes, metastasis (TNM) staging is routinely incorporated into radiology reports. We conducted a national survey to determine whether radiologists routinely address staging, in particular regarding T (primary tumor) and N (nodal). MATERIALS AND METHODS: The survey was sent to 782 members of the American Society of Head and Neck Radiology...
August 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26981511/to-evaluate-disparity-between-clinical-and-pathological-tumor-node-metastasis-staging-in-oral-cavity-squamous-cell-carcinoma-patients-and-its-impact-on-overall-survival-an-institutional-study
#19
Karan Gupta, Naresh K Panda, Jaimanti Bakshi, Ashim Das
BACKGROUND: Accurate clinical staging is important for patient counseling, treatment planning, prognostication, and rational design of clinical trials. In head and neck squamous cell carcinoma, discrepancy between clinical and pathological staging has been reported. OBJECTIVE: To evaluate any disparity between clinical and pathological tumor-node-metastasis (TNM) staging in oral cavity squamous cell carcinoma (OCSCC) patients and any impact of the same on survival...
October 2015: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/26917204/lip-cancer-a-clinicopathological-study-and-treatment-outcomes-in-a-25-year-experience
#20
Éder Ricardo Biasoli, Vitor Bonetti Valente, Bruna Mantovan, Francisco Urbano Collado, Sebastião Conrado Neto, Maria Lúcia Marçal Mazza Sundefeld, Glauco Issamu Miyahara, Daniel Galera Bernabé
PURPOSE: There are few clinical studies focusing on treatment outcomes of lip cancer. This study investigated the clinicopathologic variables of a large sample of patients with lip squamous cell carcinoma (LSCC) treated in a reference head and neck cancer center for the past 25 years and analyzed the influence of these variables on treatment outcomes. MATERIALS AND METHODS: This retrospective cohort study reviewed the clinical records of patients with LSCC. Epidemiologic data were age, gender, ethnicity, type of occupation, tobacco smoking, alcohol consumption, comorbid conditions, and family cancer history...
July 2016: Journal of Oral and Maxillofacial Surgery
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