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https://www.readbyqxmd.com/read/28334428/discrepancy-between-ctnm-and-ptnm-staging-of-oral-cavity-cancers-and-its-prognostic-significance
#1
Nayeon Choi, Yangseop Noh, Eun Kyu Lee, Manki Chung, Chung-Hwan Baek, Kwan-Hyuck Baek, Han-Sin Jeong
INTRODUCTION: Accurate tumor-node-metastasis(TNM) staging of oral cavity cancer(OCC) is very important in the management of this dismal disease. However, stage migration from cTNM to pTNM was found in a portion of OCC patients. The objective of this study was to determine the possible causes of discrepancy between cTNM and pTNM in OCC and the clinical impacts of stage migration. METHODS: Clinical and pathological data of 252 OCC patients were retrospectively reviewed and compared each other...
March 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28333147/solute-carrier-family-12-member-5-promotes-tumor-invasion-metastasis-of-bladder-urothelial-carcinoma-by-enhancing-nf-%C3%AE%C2%BAb-mmp-7-signaling-pathway
#2
J Y Liu, Y B Dai, X Li, K Cao, D Xie, Z T Tong, Z Long, H Xiao, M K Chen, Y L Ye, B Liu, J Tan, J Tang, Z Z Xu, Y Gan, Y H Zhou, F Deng, L Y He
Solute carrier family 12 member 5 (SLC12A5), an integral membrane KCl cotransporter, which maintains chloride homeostasis in neurons, is aberrantly expressed and involved in the tumorigenesis of certain cancers. However, the clinical significance and biological role of SLC12A5 in human bladder urothelial carcinoma (BUC) remains unclear. In this study, the expression of SLC12A5 was examined in clinical specimens of primary BUC and in BUC cell lines using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), western blot and immunohistochemistry (IHC)...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28331344/adverse-prognostic-impact-of-tgfb1-t869c-polymorphism-in-non-small-cell-lung-cancer
#3
Yulan Sang, Xin Bi, Yan Liu, Wei Zhang, Dongjie Wang
Previously, several polymorphisms in TGFB1 have been identified in non-small-cell lung cancer (NSCLC), and the variants, C-509T, T869C, and G915C, have been demonstrated to associate with higher circulating levels of TGF-β1. However, little is known about the prognostic value of TGF-β1 polymorphisms in cancers. In this study, by genotyping the TGF-β1 T869C polymorphism in a total of 261 patients with NSCLC using DNA from blood lymphocytes, we first found that NSCLC patients, especially those with allele C carriers, had significantly higher serum TGF-β1 levels than healthy individuals...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28331235/analysis-of-prognostic-factors-for-survival-after-surgery-for-gallbladder-cancer-based-on-a-bayesian-network
#4
Zhi-Qiang Cai, Peng Guo, Shu-Bin Si, Zhi-Min Geng, Chen Chen, Long-Long Cong
The factors underlying prognosis for gallbladder cancer (GBC) remain unclear. This study combines the Bayesian network (BN) with importance measures to identify the key factors that influence GBC patient survival time. A dataset of 366 patients who underwent surgical treatment for GBC was employed to establish and test a BN model using BayesiaLab software. A tree-augmented naïve Bayes method was also used to mine relationships between factors. Composite importance measures were applied to rank the influence of factors on survival time...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327459/preoperative-t-staging-of-potentially-resectable-esophageal-cancer-a-comparison-between-free-breathing-radial-vibe-and-breath-hold-cartesian-vibe-with-histopathological-correlation
#5
Fengguang Zhang, Jinrong Qu, Hongkai Zhang, Hui Liu, Jianjun Qin, Zhidan Ding, Yin Li, Jie Ma, Zhongxian Zhang, Zhaoqi Wang, Jianwei Zhang, Shouning Zhang, Yafeng Dong, Robert Grimm, Ihab R Kamel, Hailiang Li
PURPOSE: To compare the T staging of potentially resectable esophageal cancer using free-breathing radial VIBE (r-VIBE) and breath-hold Cartesian VIBE (C-VIBE), with pathologic confirmation of the T stage. MATERIALS AND METHODS: Fifty patients with endoscopically proven esophageal cancer and indeterminate T1/T2/T3 stage by CT scan were examined on a 3-T scanner. The MRI protocol included C-VIBE at 150 seconds post-IV contrast, immediately followed by a work-in-progress r-VIBE with identical spatial resolution (1...
March 16, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28327158/the-clinicopathological-parameters-and-prognostic-significance-of-her2-expression-in-gastric-cancer-patients-a-meta-analysis-of-literature
#6
REVIEW
Yu-Ying Lei, Jin-Yu Huang, Qiong-Rui Zhao, Nan Jiang, Hui-Mian Xu, Zhen-Ning Wang, Hai-Qing Li, Shi-Bo Zhang, Zhe Sun
BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is regarded as an important and promising target in the treatment of HER2-positive breast cancers. However, the correlation of clinicopathological characteristics and prognostic significance of HER2 overexpression in gastric cancer patients remains unclear. Our aim was to clarify this issue. METHODS: Embase, PubMed, and the Cochrane Library were searched for relevant articles published up to May 2016. Outcomes of interest contained sex, age, tumor size, tumor site, tumor node metastasis (TNM) stage, distant metastasis, lymph node metastasis, Lauren's classification, differentiation grade, lymphovascular invasion, neural invasion, and multivariate analysis data for overall survival...
March 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28325647/correlation-between-preoperative-tomographic-staging-and-definitive-histopathologic-results-in-gastric-cancer-at-the-hospital-central-militar
#7
M A López-Ramírez, C D Lever-Rosas, G A Motta-Ramírez, V Rebollo-Hurtado, J Guzmán-Bárcenas, J V Fonseca-Morales, M A Carreño-Lomeli
BACKGROUND: In relation to the number of new cases diagnosed, gastric cancer is the fourth most common cancer worldwide, and the second cause of cancer death. The development of multidetector tomography has improved the preoperative staging of gastric cancer. AIM: To correlate preoperative tomographic studies with the definitive pathologic results according to the TNM staging system. METHODS: A retrospective, cross-sectional study within the time frame of January 2009 to December 2013 was conducted that included the case records of 67 patients...
March 18, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28325607/japanese-clinical-practice-guideline-for-head-and-neck-cancer
#8
REVIEW
Ken-Ichi Nibu, Ryuichi Hayashi, Takahiro Asakage, Hiroya Ojiri, Yoshihiro Kimata, Takeshi Kodaira, Toshitaka Nagao, Torahiko Nakashima, Takashi Fujii, Hirofumi Fujii, Akihiro Homma, Kazuto Matsuura, Nobuya Monden, Takeshi Beppu, Nobuhiro Hanai, Tadaaki Kirita, Yuzuru Kamei, Naoki Otsuki, Naomi Kiyota, Sadamoto Zenda, Ken Omura, Koichi Omori, Tetsuo Akimoto, Kazuyoshi Kawabata, Seiji Kishimoto, Hiroya Kitano, Iwai Tohnai, Takashi Nakatsuka
OBJECTIVE: The first revision of "Japanese Clinical Practice Guideline for Head and Neck Cancer" was made in 2013 by the clinical practice guideline committee of Japan Society for Head and Neck Cancer, in response to the revision of the TNM classification. METHODS: 34 CQs (Clinical Questions) were newly adopted to describe the diagnosis and treatment methods currently considered most appropriate, and offered recommendation grade made by the consensus of the committee...
March 18, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28325129/lobectomy-for-non-small-cell-lung-carcinoma-a-nationwide-study-of-short-and-long-term-survival
#9
G N Oskarsdottir, H Halldorsson, M I Sigurdsson, B M Fridriksson, K Baldvinsson, A W Orrason, S Jonsson, M Planck, T Gudbjartsson
INTRODUCTION: Lobectomy is the standard curative treatment for non-small cell carcinoma (NSCLC) of the lung. Most studies on lobectomy have focused on short-term outcome and 30-day mortality. The aim of this study was to determine both short-term and long-term surgical outcome in all patients who underwent lobectomy for NSCLC in Iceland over a 24-year period. MATERIAL AND METHODS: The study involved 489 consecutive patients with NSCLC who underwent lobectomy with curative intent in Iceland, 1991-2014...
March 21, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28321405/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-lymphocyte-to-monocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-nasopharyngeal-carcinoma
#10
Aiying Lu, Haifeng Li, Yuming Zheng, Minzhong Tang, Jun Li, Huihui Wu, Weiming Zhong, Jianquan Gao, Ningjiang Ou, Yonglin Cai
The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28318929/biomarkers-in-diagnosis-and-therapy-of-oral-squamous-cell-carcinoma-a-review-of-the-literature
#11
Sebastian Blatt, Maximilian Krüger, Thomas Ziebart, Keyvan Sagheb, Eik Schiegnitz, Elisabeth Goetze, Bilal Al-Nawas, Andreas Max Pabst
Oral squamous cell carcinoma (OSCC) represents the sixth most common cancer, accounting for 2-4% of all malignancies worldwide. The overall survival rate of less than 60% remains generally poor, with prognosis heavily relying on the TNM staging system. Tumor size as well as the presence and extent of lymph node metastases are widely recognized as the most important predictors. However, the underlying mechanisms that lead to an aggressive phenotype are not yet fully understood. Therefore, possible biomarkers are much in need to predict prognosis, to help individualize therapy approaches, and to overcome possible resistance mechanisms...
February 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28317152/-68-ga-psma-pet-for-radiation-treatment-planning-in-prostate-cancer-recurrences-after-surgery-individualized-medicine-or-new-standard-in-salvage-treatment
#12
Gregor Habl, Katharina Sauter, Kilian Schiller, Sabrina Dewes, Tobias Maurer, Matthias Eiber, Stephanie E Combs
BACKGROUND: (68) Ga-PSMA-PET imaging is a novel promising diagnostic tool to locate early biochemical failure after radical prostatectomy (RP) in prostate cancer (PC) patients. Exact knowledge of the relapse location may result in changes of the therapy concept aside from changes to the TNM stage. To gain data for this approach, we evaluated PC patients receiving (68) Ga-PSMA-PET imaging before salvage radiotherapy (RT). METHODS AND MATERIALS: In this study, 100 patients with biochemical failure after RP± prior RT who underwent (68) Ga-PSMA PET/CT or PET/MRI were evaluated undergoing salvage RT in our department...
March 20, 2017: Prostate
https://www.readbyqxmd.com/read/28316326/overexpression-of-rab1b-and-mmp9-predicts-poor-survival-and-good-response-to-chemotherapy-in-patients-with-colorectal-cancer
#13
Xian-Zi Yang, Shu-Zhong Cui, Li-Si Zeng, Tian-Tian Cheng, Xiao-Xing Li, Jun Chi, Ren Wang, X F Steven Zheng, Hui-Yun Wang
Rab1B has recently been reported to be involved in human cancer, but the role of Rab1B in colorectal cancer (CRC) remains unclear. In this study, we investigated the expression of Rab1B and MMP9 in CRC by qRT-PCR, immunoblot and immunohistochemistry and analyzed the clinical significance. The results show that Rab1B and MMP9 are increased at both mRNA and protein levels in CRC cell lines and tissues, as measured by qRT-PCR and immunoblotting. The high protein expression of Rab1B and MMP9 in 179 CRC tissues is associated with deep tumor invasion, lymph-node metastasis and advanced TNM stage...
March 18, 2017: Aging
https://www.readbyqxmd.com/read/28316215/-effect-of-preoperative-monocyte-lymphocyte-ratio-on-prognosis-of-patients-with-resectable-esophagogastric-junction-cancer
#14
W J Zhou, J Wu, X D Li, Q Wang, X F Ni, J T Jiang, M Ji, C P Wu
Objective: To investigate the associations between various blood test parameters including MLR (monocyte-lymphocyte ratio) and prognosis in post-operative esophagogastric junction cancer patients. Methods: We retrospectively studied the preoperative and postoperative data of 309 patients who underwent radical surgery for esophagogastric junction cancer. The relationship between MLR, neutrophil lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and overall survival (OS) was analyzed. Results: The cutoff values of MLR、NLR and PLR were 0...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28316213/-expression-of-lim-and-sh3-protein-1-in-renal-clear-cell-carcinoma-and-its-effects-on-invasion-and-migration-of-renal-clear-cell-carcinoma-786-o-cells
#15
B Jin, L Gao, W Li, J C Chen, R M Wen, J Q Wang
Objective: To investigate the expression of LIM and SH3 protein 1 (LASP1) in renal cell carcinoma and its significance in the invasion and migration of renal clear cell carcinoma 786-O cell line. Methods: The expression level of LASP1 in 41 cases of renal cell carcinoma tissues and normal renal tissues was analyzed by immunohistochemistry. The relationship between the expression level of LASP1 and clinical characteristics was further analyzed. Expression of LASP1 in 10 cases of tumor tissues with or without lymph node metastasis was analyzed by Western blot...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28316053/the-use-of-rapid-and-cost-effective-blood-based-biomarkers-in-combination-with-tumour-tnm-stage-for-individual-head-and-neck-cancer-patient-treatment-selection
#16
REVIEW
Nongnit Laytragoon Lewin, Freddi Lewin, Bengt-Åke Andersson, Sture Löfgren, Lars Erik Rutqvist
Head and neck (H&N) cancer is an aggressive disease and the incidence has increased in younger population worldwide. Tumour TNM staging is the main basis for treatment decision despite significant variation in clinical outcome. Survival time of these patients has marginally improved during the last 30 years. Various biomarkers with cumbersome analysis, high cost, time consumption and requirement of special laboratory facilities have been investigated. However, none of these biomarkers have been shown to be suitable to use for individual H&N cancer patient treatment selection in the clinic...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28315505/clinicopathological-and-prognostic-value-of-cd24-expression-in-breast-cancer-a-meta-analysis
#17
Gao Liu, Guo-Xing Liu, Yu Fang, Zhen-Yu Cao, Hui-Hui Du, Jie Fu, Ke Qian
BACKGROUND: A number of studies have been conducted to explore the relationship between CD24 expression and the prognosis of breast cancer; however, the results remain inconsistent. Therefore, we performed this meta-analysis to clarify the impact of CD24 expression on clinicopathological features and prognosis of breast cancer. METHODS: A comprehensive literature search for relevant studies was performed, and statistical analysis was conducted using Stata software...
March 3, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28315180/inflammation-based-indexes-and-clinicopathologic-features-are-strong-predictive-values-of-preoperative-circulating-tumor-cell-detection-in-gastric-cancer-patients
#18
L Zheng, K Zou, C Yang, F Chen, T Guo, B Xiong
PURPOSE: Circulating tumor cell (CTC) count and the host inflammatory response are two independent predictors for patients with various malignant disease. Several inflammation-based indicators have been demonstrated to have prognostic value in many malignant solid tumors, including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). The aim of this study was to evaluate the predictive value of the inflammation-based indexes including SII, NLR PLR, and PNI for CTC detection of gastric cancer patients before surgery...
March 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28315167/development-of-a-predictive-model-for-6-month-survival-in-patients-with-venous-thromboembolism-and-solid-malignancy-requiring-ivc-filter-placement
#19
Steven Y Huang, Bruno C Odisio, Sharjeel H Sabir, Joe E Ensor, Andrew S Niekamp, Tam T Huynh, Michael Kroll, Sanjay Gupta
PURPOSE: Our purpose was to develop a predictive model for short-term survival (i.e. <6 months) following inferior vena cava filter placement in patients with venous thromboembolism (VTE) and solid malignancy. METHODS: Clinical and laboratory parameters were retrospectively reviewed for patients with solid malignancy who received a filter between January 2009 and December 2011 at a tertiary care cancer center. Multivariate Cox proportional hazards modeling was used to assess variables associated with 6 month survival following filter placement in patients with VTE and solid malignancy...
March 17, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28315008/the-optimal-cut-off-value-of-the-preoperative-prognostic-nutritional-index-for-the-survival-differs-according-to-the-tnm-stage-in-hepatocellular-carcinoma
#20
Yukiyasu Okamura, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhiko Uesaka
PURPOSE: To establish the optimal cut-off value of the preoperative prognostic nutritional index (PNI) for prognosis according to the Tumor Node Metastasis (TNM) stage of hepatocellular carcinoma (HCC) after curative resection. METHODS: This retrospective study reviewed the records of 375 patients. The optimal cut-off value of the PNI was established according to the TNM stage, and overall survival was compared between the low and high PNI groups. RESULTS: The optimal cut-off value of the PNI decreased with increasing TNM stage, with 52, 47, and 43 patients having stage I, II, and III HCC, respectively...
March 17, 2017: Surgery Today
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