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https://www.readbyqxmd.com/read/29736674/modulation-of-vascular-reactivity-by-perivascular-adipose-tissue-pvat
#1
REVIEW
Claudia Agabiti-Rosei, Anna Paini, Carolina De Ciuceis, Sarah Withers, Adam Greenstein, Anthony M Heagerty, Damiano Rizzoni
PURPOSE OF REVIEW: In this review, we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/inflammation. RECENT FINDINGS: PVAT possesses a relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades, it has been shown that PVAT may modulate vascular reactivity...
May 7, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29720945/decrease-of-perivascular-adipose-tissue-browning-is-associated-with-vascular-dysfunction-in-spontaneous-hypertensive-rats-during-aging
#2
Ling-Ran Kong, Yan-Ping Zhou, Dong-Rui Chen, Cheng-Chao Ruan, Ping-Jin Gao
Functional perivascular adipose tissue (PVAT) is necessary to maintain vascular physiology through both mechanical support and endocrine or paracrine ways. PVAT shows a brown adipose tissue (BAT)-like feature and the browning level of PVAT is dependent on the anatomic location and species. However, it is not clear whether PVAT browning is involved in the vascular tone regulation in spontaneously hypertensive rats (SHRs). In the present study, we aimed to illustrate the effect of aging on PVAT browning and subsequent vasomotor reaction in SHRs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29681862/increased-o-glcnacylation-of-endothelial-nitric-oxide-synthase-compromises-the-anti-contractile-properties-of-perivascular-adipose-tissue-in-metabolic-syndrome
#3
Rafael M da Costa, Josiane F da Silva, Juliano V Alves, Thiago B Dias, Diane M Rassi, Luis V Garcia, Núbia de Souza Lobato, Rita C Tostes
Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight and hyperglycemia. The O -linked β-N-acetylglucosamine ( O -GlcNAc) modification of proteins ( O -GlcNAcylation) is a unique posttranslational process that integrates glucose metabolism with intracellular protein activity...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29669585/endoplasmic-reticulum-stress-in-perivascular-adipose-tissue-promotes-destabilization-of-atherosclerotic-plaque-by-regulating-gm-csf-paracrine
#4
Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. METHODS: We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from donor mice to carotid arteries of recipient apolipoprotein E deficient (apoE-/- ) mice after removing carotid artery collar placed for 6 weeks...
April 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29628894/insulin-receptor-substrate-2-controls-insulin-mediated-vasoreactivity-and-perivascular-adipose-tissue-function-in-muscle
#5
Alexander H Turaihi, Wineke Bakker, Victor W M van Hinsbergh, Erik H Serné, Yvo M Smulders, Hans W M Niessen, Etto C Eringa
Introduction: Insulin signaling in adipose tissue has been shown to regulate insulin's effects in muscle. In muscle, perivascular adipose tissue (PVAT) and vascular insulin signaling regulate muscle perfusion. Insulin receptor substrate (IRS) 2 has been shown to control adipose tissue function and glucose metabolism, and here we tested the hypothesis that IRS2 mediates insulin's actions on the vessel wall as well as the vasoactive properties of PVAT. Methods: We studied PVAT and muscle resistance arteries (RA) from littermate IRS2+/+ and IRS2-/- mice and vasoreactivity by pressure myography, vascular insulin signaling, adipokine expression, and release and PVAT morphology...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29618983/perivascular-adipose-tissue-as-a-relevant-fat-depot-for-cardiovascular-risk-in-obesity
#6
REVIEW
Rafael M Costa, Karla B Neves, Rita C Tostes, Núbia S Lobato
Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure. However, this is not a straightforward relationship. Although several studies have substantiated that obesity confers an independent and additive risk of all-cause and cardiovascular death, there is significant variability in these associations, with some lean individuals developing diseases and others remaining healthy despite severe obesity, the so-called metabolically healthy obese...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29615924/protective-role-of-perivascular-adipose-tissue-in-endothelial-dysfunction-and-insulin-induced-vasodilatation-of-hypercholesterolemic-ldl-receptor-deficient-mice
#7
Natali Baltieri, Daniele M Guizoni, Jamaira A Victorio, Ana P Davel
Background: Endothelial dysfunction plays a pivotal role in the initiation of atherosclerosis. Vascular insulin resistance might contribute to a reduction in endothelial nitric oxide (NO) production, leading to impaired endothelium-dependent relaxation in cardiometabolic diseases. Because perivascular adipose tissue (PVAT) controls endothelial function and NO bioavailability, we hypothesized a role for this fat deposit in the vascular complications associated with the initial stages of atherosclerosis. Therefore, we investigated the potential involvement of PVAT in the early endothelial dysfunction in hypercholesterolemic LDL receptor knockout mice (LDLr-KO)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29595858/calycosin-directly-improves-perivascular-adipose-tissue-dysfunction-by-upregulating-the-adiponectin-ampk-enos-pathway-in-obese-mice
#8
Fang Han, Kai Li, Ruiyan Pan, Wenjie Xu, Xue Han, Ningning Hou, Xiaodong Sun
Perivascular adipose tissue (PVAT) loses its anti-contractile activity in obesity. Calycosin, the major bioactive isoflavonoid, was shown to protect endothelial function. However, effects of calycosin on PVAT function in obesity remain unclear. We aimed to investigate the effects of calycosin on the anti-contractile activity of PVAT in obese mice and its potential mechanisms. Obesity in mice was induced with a high-fat diet, with or without calycosin treatment. Thoracic aorta responses to phenylephrine were determined...
March 29, 2018: Food & Function
https://www.readbyqxmd.com/read/29530798/depletion-of-dendritic-cells-in-perivascular-adipose-tissue-improves-arterial-relaxation-responses-in-type-2-diabetic-mice
#9
Tianyi Qiu, Min Li, Miles A Tanner, Yan Yang, James R Sowers, Ronald J Korthuis, Michael A Hill
BACKGROUND: Accumulation of multiple subtypes of immune cells in perivascular adipose tissue (PVAT) has been proposed to cause vascular inflammation and dysfunction in type 2 diabetes (T2DM). This study was designed to investigate specific roles for dendritic cells in PVAT in the development of vascular inflammation and impaired PVAT-mediated vasorelaxation in T2DM. METHODS AND RESULTS: Studies were performed using db/db mice (model of T2DM) and their Db heterozygote (DbHET), lean and normoglycemic controls...
March 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29496660/role-of-sympathetic-nerves-and-adipocyte-catecholamine-uptake-in-the-vasorelaxant-function-of-perivascular-adipose-tissue
#10
Sophie N Saxton, Katie E Ryding, Robert G Aldous, Sarah B Withers, Jacqueline Ohanian, Anthony M Heagerty
OBJECTIVE: Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3 -adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicated in this effect and may stimulate the release of the vasodilator adiponectin from adipocytes. Understanding the mechanisms responsible is vital for determining how PVAT may modify vascular resistance in vivo. APPROACH AND RESULTS: Electrical field stimulation profiles of healthy C57BL/6J mouse mesenteric resistance arteries were characterized using wire myography...
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29487532/roles-of-perivascular-adipose-tissue-in-the-pathogenesis-of-atherosclerosis
#11
REVIEW
Kimie Tanaka, Masataka Sata
Traditionally, it is believed that white adipose tissues serve as energy storage, heat insulation, and mechanical cushion, whereas non-shivering thermogenesis occurs in brown adipose tissue. Recent evidence revealed that adipose tissue secretes many types of cytokines, called as adipocytokines, which modulate glucose metabolism, lipid profile, appetite, fibrinolysis, blood pressure, and inflammation. Most of the arteries are surrounded by perivascular adipose tissue (PVAT). PVAT has been thought to be simply a structurally supportive tissue for vasculature...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29479319/high-fat-diet-attenuates-the-anticontractile-activity-of-aortic-pvat-via-a-mechanism-involving-ampk-and-reduced-adiponectin-secretion
#12
Tarek A M Almabrouk, Anna D White, Azizah B Ugusman, Dominik S Skiba, Omar J Katwan, Husam Alganga, Tomasz J Guzik, Rhian M Touyz, Ian P Salt, Simon Kennedy
Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity. The enzyme AMP-activated protein kinase (AMPK) is present in PVAT and is implicated in mediating the vascular effects of adiponectin. In this study, we investigated the effect of an obesogenic high fat diet (HFD) on aortic PVAT and whether any changes involved AMPK. Methods: Wild type Sv129 (WT) and AMPKα1 knockout (KO) mice aged 8 weeks were fed normal diet (ND) or HFD (42% kcal fat) for 12 weeks...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467675/pvat-and-its-relation-to-brown-beige-and-white-adipose-tissue-in-development-and-function
#13
REVIEW
Staffan Hildebrand, Jasmin Stümer, Alexander Pfeifer
Adipose tissue is commonly categorized into three types with distinct functions, phenotypes, and anatomical localizations. White adipose tissue (WAT) is the major energy store; the largest depots of WAT are found in subcutaneous or intravisceral sites. Brown adipose tissue (BAT) is responsible for energy dissipation during cold-exposure (i.e., non-shivering thermogenesis) and is primarily located in the interscapular region. Beige or brite (brown-in-white) adipose tissue can be found interspersed in WAT and can attain a brown-like phenotype...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29464937/vascular-dysfunction-elicited-by-a-cross-talk-between-periaortic-adipose-tissue-and-the-vascular-wall-is-reversed-by-pioglitazone
#14
Isabel Quesada, Jimena Cejas, Rodrigo García, Beatriz Cannizzo, Analía Redondo, Claudia Castro
AIM: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29454047/renal-perivascular-adipose-tissue-form-and-function
#15
Carolina Baraldi A Restini, Alex Ismail, Ramya K Kumar, Robert Burnett, Hannah Garver, Gregory D Fink, Stephanie W Watts
Renal sympathetic activity affects blood pressure in part by increasing renovascular resistance via release of norepinephrine (NE) from sympathetic nerves onto renal arteries. Here we test the idea that adipose tissue adjacent to renal blood vessels, i.e. renal perivascular adipose tissue (RPVAT), contains a pool of NE which can be released to alter renal vascular function. RPVAT was obtained from around the main renal artery/vein of the male Sprague Dawley rats. Thoracic aortic PVAT and mesenteric PVAT also were studied as brown-like and white fat comparators respectively...
February 15, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29425108/neck-adipose-tissue-tying-ties-in-metabolic-disorders
#16
REVIEW
Vlatka Pandzic Jaksic, Danijela Grizelj, Ana Livun, Drago Boscic, Marko Ajduk, Rajko Kusec, Ozren Jaksic
Upper body adipose tissue accumulation has been associated with clustering of metabolic disorders and increased cardiovascular risk. Neck circumference (NC) indicated that subcutaneous adipose tissue (SAT) in that region is an independent pathogenic depot that might account for the additional risk missed by visceral adipose tissue (VAT). Neck adipose tissue (NAT) is not only one more ectopic depot but has several particular features that might modulate its metabolic role. Besides a controversial impact on obstructive apnea syndrome, neck fat encompasses carotid arteries as an important perivascular adipose tissue (PVAT) depot...
February 9, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29396370/distinct-adipocyte-progenitor-cells-are-associated-with-regional-phenotypes-of-perivascular-aortic-fat-in-mice
#17
Khanh-Van Tran, Timothy Fitzgibbons, So Yun Min, Tiffany DeSouza, Silvia Corvera
OBJECTIVE: Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). It is not known whether this distinction is due to the in-vivo functional environment or to cell-autonomous traits that persist outside the in-vivo setting. In this study, we asked whether the progenitor cells in tPVAT and aPVAT have cell-autonomous traits that lead to formation of regionally distinct PVAT...
March 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29389358/coronary-adventitial-and-perivascular-adipose-tissue-inflammation-in-patients-with-vasospastic-angina
#18
Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Hiroaki Shimokawa
BACKGROUND: Recent studies suggested that perivascular components, such as perivascular adipose tissue (PVAT) and adventitial vasa vasorum (VV), play an important role as a source of various inflammatory mediators in cardiovascular disease. OBJECTIVES: The authors tested their hypothesis that coronary artery spasm is associated with perivascular inflammation in patients with vasospastic angina (VSA) using 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT)...
January 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29371216/bmal1-in-perivascular-adipose-tissue-regulates-resting-phase-blood-pressure-through-transcriptional-regulation-of-angiotensinogen
#19
Lin Chang, Wenhao Xiong, Xiangjie Zhao, Yanbo Fan, Yanhong Guo, Minerva Garcia-Barrio, Jifeng Zhang, Zhisheng Jiang, Jiandie D Lin, Y Eugene Chen
Background -The perivascular adipose tissue (PVAT), surrounding vessels, constitutes a distinct functional integral layer of the vasculature required to preserve vascular tone under physiological conditions. However, there is little information regarding the relationship between PVAT and blood pressure regulation, including its potential contributions to circadian blood pressure variation. Methods -Using unique brown adipocyte-specific aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) and angiotensinogen (Agt) knock out mice we determined the vasoactivity of homogenized PVAT in aortic rings and how brown-adipocyte peripheral expression of Bmal1 and Agt in PVAT regulate the amplitude of diurnal change in blood pressure in mice...
January 25, 2018: Circulation
https://www.readbyqxmd.com/read/29357124/role-of-perivascular-adipose-tissue-in-health-and-disease
#20
Maria S Fernández-Alfonso, Beatriz Somoza, Dmitry Tsvetkov, Artur Kuczmanski, Mick Dashwood, Marta Gil-Ortega
Perivascular adipose tissue (PVAT) is cushion of fat tissue surrounding blood vessels, which is phenotypically different from other adipose tissue depots. PVAT is composed of adipocytes and stromal vascular fraction, constituted by different populations of immune cells, endothelial cells, and adipose-derived stromal cells. It expresses and releases an important number of vasoactive factors with paracrine effects on vascular structure and function. In healthy individuals, these factors elicit a net anticontractile and anti-inflammatory paracrine effect aimed at meeting hemodynamic and metabolic demands of specific organs and regions of the body...
December 12, 2017: Comprehensive Physiology
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