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gracely fibromyalgia

Cynthia J Schoen, Jacob N Ablin, Eric Ichesco, Rupal J Bhavsar, Laura Kochlefl, Richard E Harris, Daniel J Clauw, Richard H Gracely, Steven E Harte
INTRODUCTION: Application of noxious stimulation to one body area reduces pain sensitivity in a remote body area through activation of an endogenous pain-inhibitory network, a behavioral phenomenon referred to as conditioned pain modulation (CPM). The efficiency of CPM is predictive of a variety of health outcomes, while impaired CPM has been associated with various chronic pain conditions. Current methods used to assess CPM vary widely, and interest in CPM method development remains strong...
2016: Journal of Pain Research
K Thieme, D C Turk, R H Gracely, H Flor
BACKGROUND: Determination of psychophysiological effects of operant behavioural (OBT) and cognitive behavioural treatment (CBT) for fibromyalgia patients. METHODS: One hundred and fifteen female patients randomized to OBT (N = 43), CBT (N = 42), or whole-body infrared heat (IH) (N = 30) were compared before and after group treatment as well as at 6- and 12-month follow-ups using intent-to-treat analysis (12 drop-outs). Thirty matched pain-free controls (CON) served as reference group for the initial psychophysiological analysis...
October 2016: European Journal of Pain: EJP
Laura K Case, Marta Čeko, John L Gracely, Emily A Richards, Håkan Olausson, M Catherine Bushnell
Touch plays a significant role in human social behavior and social communication, and its rewarding nature has been suggested to involve opioids. Opioid blockade in monkeys leads to increased solicitation and receipt of grooming, suggesting heightened enjoyment of touch. We sought to study the role of endogenous opioids in perception of affective touch in healthy adults and in patients with fibromyalgia, a chronic pain condition shown to involve reduced opioid receptor availability. The pleasantness of touch has been linked to the activation of C-tactile fibers, which respond maximally to slow gentle touch and correlate with ratings of pleasantness...
January 2016: ENeuro
Brian Walitt, Marta Čeko, Manish Khatiwada, John L Gracely, Rakib Rayhan, John W VanMeter, Richard H Gracely
The subjective experience of cognitive dysfunction ("fibrofog") is common in fibromyalgia. This study investigated the relation between subjective appraisal of cognitive function, objective cognitive task performance, and brain activity during a cognitive task using functional magnetic resonance imaging (fMRI). Sixteen fibromyalgia patients and 13 healthy pain-free controls completed a battery of questionnaires, including the Multiple Ability Self-Report Questionnaire (MASQ), a measure of self-perceived cognitive difficulties...
2016: NeuroImage: Clinical
Richard H Gracely, Petra Schweinhardt
Central sensitivity syndromes (CSS) share features of similar multiple symptoms, virtually unknown mechanisms and lack of effective treatments. The CSS nomenclature was chosen over alternatives because it focused on a putative physiological mechanism of central sensitization common to disorders such as fibromyalgia, irritable bowel syndrome, vulvodynia and temporomandibular disorder. Increasing evidence from multiple biological systems suggests a further development. In this new model central sensitization is part of a ensemble that includes also the symptoms of widespread pain, fatigue, unrefreshing sleep and dyscognition...
2015: Current Rheumatology Reviews
Richard H Gracely, Petra Schweinhardt
No abstract text is available yet for this article.
January 2015: Clinical and Experimental Rheumatology
Kati Thieme, Dennis C Turk, Richard H Gracely, William Maixner, Herta Flor
UNLABELLED: This study examined the relationship of psychophysiological response patterns in fibromyalgia with psychological characteristics and comorbid mental disorders. Surface electromyographic data, systolic and diastolic blood pressure, heart rate (HR), and skin conductance levels were recorded continuously during baseline, stress, and relaxation tasks. Cluster analysis revealed 4 subgroups of patients who differed on pain characteristics and cognitive, affective, and behavioral responses to pain and stress...
February 2015: Journal of Pain: Official Journal of the American Pain Society
Karin B Jensen, Frank Petzke, Serena Carville, Ernest Choy, Peter Fransson, Richard H Gracely, Olivier Vitton, Hanke Marcus, Steven C R Williams, Martin Ingvar, Eva Kosek
UNLABELLED: Antidepressant drugs are commonly used to treat fibromyalgia, but there is little knowledge about their mechanisms of action. The aim of this study was to compare the cerebral and behavioral response to positive treatment effects of antidepressants or placebo. Ninety-two fibromyalgia patients participated in a 12-week, double-blind, placebo-controlled clinical trial with milnacipran, a serotonin-norepinephrine reuptake inhibitor. Before and after treatment, measures of cerebral pain processing were obtained using functional magnetic resonance imaging...
December 2014: Journal of Pain: Official Journal of the American Pain Society
Jacob N Ablin, Daniel J Clauw, Angela K Lyden, Kirsten Ambrose, David A Williams, Richard H Gracely, Jennifer M Glass
OBJECTIVES: Exposure to acute 'stressors' (e.g. infections, pain, trauma) often results in altered sleep habits and reductions in routine activity. In some individuals, these behavioural responses to acute stressors may contribute to the development of chronic somatic symptoms such as widespread pain, fatigue, memory difficulties and mood disturbances, much like those associated with 'functional somatic syndromes' (FSS) such as fibromyalgia or chronic fatigue syndrome. METHODS: Eighty-seven healthy young adults who reported sleeping between 7 and 9 hours nightly and exercising regularly were randomised to one of four groups: exercise cessation, sleep restriction (6 hours nightly), both, or neither...
November 2013: Clinical and Experimental Rheumatology
Karin B Jensen, Priti Srinivasan, Rosa Spaeth, Ying Tan, Eva Kosek, Frank Petzke, Serena Carville, Peter Fransson, Hanke Marcus, Steven C R Williams, Ernest Choy, Olivier Vitton, Richard Gracely, Martin Ingvar, Jian Kong
OBJECTIVE: There is vast evidence to support the presence of brain aberrations in patients with fibromyalgia (FM), and it is possible that central plasticity is critical for the transition from acute to chronic pain. The aim of the present study was to investigate the relationship between brain structure and function in patients with FM. METHODS: Functional connectivity of the brain during application of intermittent pressure-pain stimuli and measures of brain structure were compared between 26 patients with FM and 13 age- and sex-matched healthy controls...
December 2013: Arthritis and Rheumatism
Johnson P Hampson, Barbara D Reed, Daniel J Clauw, Rupal Bhavsar, Richard H Gracely, Hope K Haefner, Richard E Harris
UNLABELLED: Vulvodynia (VVD) is a chronic pain disorder wherein women display sensitivity to evoked stimuli at the vulva and/or spontaneous vulvar pain. Our previous work suggests generalized hyperalgesia in this population; however, little is known about central neurobiological factors that may influence pain in VVD. Here we investigated local (vulvar) and remote (thumb) pressure-evoked pain processing in 24 VVD patients compared to 13 age-matched, pain-free healthy controls (HCs). As a positive control we also examined thumb pressure pain in 24 fibromyalgia patients...
June 2013: Journal of Pain: Official Journal of the American Pain Society
Dennis C Ang, Mark P Jensen, Jennifer L Steiner, Janna Hilligoss, Richard H Gracely, Chandan Saha
OBJECTIVES: To evaluate the feasibility of a randomized-controlled trial and to obtain estimates of the effects of combined cognitive-behavioral therapy (CBT) and milnacipran for the treatment of fibromyalgia. METHODS: Fifty-eight patients with fibromyalgia were randomized to 1 of the 3 treatment arms: (1) combination therapy (n = 20); (2) milnacipran+education (n = 19); and (3) placebo+CBT (n = 19). Patients received either milnacipran (100 mg/d) or placebo. Patients also received 8 sessions of phone-delivered CBT or educational instructions, but only from baseline to week 9...
September 2013: Clinical Journal of Pain
K R Ambrose, R H Gracely, J M Glass
Fibromyalgia is characterized by widespread pain and tenderness; however, comorbid cognitive difficulties are a common complaint among patients. Known as fibro fog or dyscognition, this symptom comprises difficulties with complex cognitive processes including memory, executive function, concentration and attention. While the mechanisms that initiate and maintain these cognitive deficits are still largely unknown, recent research has increased the understanding of subjective symptoms and objectively-determined deficits in cognitive performance...
2012: Reumatismo
Karin B Jensen, Rita Loitoile, Eva Kosek, Frank Petzke, Serena Carville, Peter Fransson, Hanke Marcus, Steven C R Williams, Ernest Choy, Yves Mainguy, Olivier Vitton, Richard H Gracely, Randy Gollub, Martin Ingvar, Jian Kong
BACKGROUND: There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need for closer investigation of endogenous pain modulation. In the present study, we compared the functional connectivity of the descending pain inhibitory network in age-matched FM patients and healthy controls (HC).We performed functional magnetic resonance imaging (fMRI) in 42 subjects; 14 healthy and 28 age-matched FM patients (2 patients per HC), during randomly presented, subjectively calibrated pressure pain stimuli...
2012: Molecular Pain
Martin Diers, Pinar Yilmaz, Mariela Rance, Kati Thieme, Richard H Gracely, Claudia Rolko, Marcus T Schley, Ulrike Kiessling, Haili Wang, Herta Flor
Little is known about the effects of successful treatment on brain function in chronic pain. This study examined changes in pain-evoked brain activation following behavioral extinction training in fibromyalgia patients. Using functional magnetic resonance imaging, brain activation to painful mechanical stimuli applied to the 2nd phalanx of the left 2nd digit (m. flexor digitorum) was assessed in 10 patients with fibromyalgia syndrome (FM) before and after behavioral extinction training. The behavioral treatment significantly reduced interference from pain in the FM patients...
May 2012: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Michael Spaeth, Robert M Bennett, Beverly A Benson, Y Grace Wang, Chinglin Lai, Ernest H Choy
BACKGROUND: Fibromyalgia is characterised by chronic musculoskeletal pain and multiple symptoms including fatigue, multidimensional function impairment, sleep disturbance and tenderness. Along with pain and fatigue, non-restorative sleep is a core symptom of fibromyalgia. Sodium oxybate (SXB) is thought to reduce non-restorative sleep abnormalities. This study evaluated effects of SXB on fibromyalgia-related pain and other symptoms. METHODS: 573 patients with fibromyalgia according to 1990 American College of Rheumatology criteria were enrolled at 108 centres in eight countries...
June 2012: Annals of the Rheumatic Diseases
Richard H Gracely, Marta Ceko, M Catherine Bushnell
Fibromyalgia and depression might represent two manifestations of affective spectrum disorder. They share similar pathophysiology and are largely targeted by the same drugs with dual action on serotoninergic and noradrenergic systems. Here, we review evidence for genetic and environmental factors that predispose, precipitate, and perpetuate fibromyalgia and depression and include laboratory findings on the role of depression in fibromyalgia. Further, we comment on several aspects of fibromyalgia which support the development of reactive depression, substantially more so than in other chronic pain syndromes...
2012: Pain Research and Treatment
Marta Ceko, M Catherine Bushnell, Richard H Gracely
Fibromyalgia is characterized by chronic widespread pain, clinical symptoms that include cognitive and sleep disturbances, and other abnormalities such as increased sensitivity to painful stimuli, increased sensitivity to multiple sensory modalities, and altered pain modulatory mechanisms. Here we relate experimental findings of fibromyalgia symptoms to anatomical and functional brain changes. Neuroimaging studies show augmented sensory processing in pain-related areas, which, together with gray matter decreases and neurochemical abnormalities in areas related to pain modulation, supports the psychophysical evidence of altered pain perception and inhibition...
2012: Pain Research and Treatment
Richard H Gracely, Kirsten R Ambrose
The primary symptom of fibromyalgia is widespread pain. This symptom is accompanied by secondary symptoms, such as cognitive difficulties and sensitivity to painful stimulation, and by numerous co-morbidities. The first neuroimaging studies addressed the primary symptom by examining differences between patients and controls using single-photon-emission-computed tomography (SPECT). Subsequent studies focussed on the secondary symptom of increased sensitivity to painful stimulation. Functional MRI (fMRI) studies using the blood-oxygen-level-dependent (BOLD) method to assess brain activation demonstrated augmented sensitivity to painful pressure and the association of this augmentation with variables such as depression and catastrophising...
April 2011: Best Practice & Research. Clinical Rheumatology
Shad B Smith, Dylan W Maixner, Roger B Fillingim, Gary Slade, Richard H Gracely, Kirsten Ambrose, Dmitri V Zaykin, Craig Hyde, Sally John, Keith Tan, William Maixner, Luda Diatchenko
OBJECTIVE: Fibromyalgia (FM) represents a complex disorder that is characterized by widespread pain and tenderness and is frequently accompanied by additional somatic and cognitive/affective symptoms. Genetic risk factors are known to contribute to the etiology of the syndrome. The aim of this study was to examine >350 genes for association with FM, using a large-scale candidate gene approach. METHODS: The study group comprised 496 patients with FM (cases) and 348 individuals with no chronic pain (controls)...
February 2012: Arthritis and Rheumatism
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