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hallucination attractor

Jasper Looijestijn, Jan Dirk Blom, André Aleman, Hans W Hoek, Rutger Goekoop
The full body of research on the nature of psychosis and its determinants indicates that a considerable number of factors are relevant to the development of hallucinations, delusions, and other positive symptoms, ranging from neurodevelopmental parameters and altered connectivity of brain regions to impaired cognitive functioning and social factors. We aimed to integrate these factors in a single mathematical model based on network theory. At the microscopic level this model explains positive symptoms of psychosis in terms of experiential equivalents of robust, high-frequency attractor states of neural networks...
December 2015: Neuroscience and Biobehavioral Reviews
Marco Loh, Edmund T Rolls, Gustavo Deco
We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the constant statistical fluctuations caused by the stochastic spiking of neurons. In integrate-and-fire network simulations, a decrease in the NMDA receptor conductances, which reduces the depth of the attractor basins, decreases the stability of short-term memory states and increases distractibility...
November 2007: PLoS Computational Biology
R E Hoffman, T H McGlashan
There is considerable neurobiological evidence suggesting that schizophrenia is associated with reduced corticocortical connectivity. The authors describe two neural network computer simulations that explore functional consequences of these abnormalities. The first utilized an "attractor" neural network capable of content-addressable memory. Application of a pruning rule that eliminated weaker connections over longer distances produced functional fragmentation and the emergence of localized, "parasitic" attractors that intruded into network dynamics...
October 2001: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
R E Hoffman
Recent studies have suggested that reduced corticocortical connectivity is associated with schizophrenia. My colleagues and I have used neural network simulations to explore parallel, distributed processing systems with reduced connectivity. These systems often behaved in a "schizophrenic-like" manner. Excessively pruned attractor networks became functionally fragmented, suggesting "loose associations," and produced recurrent, intrusive representations suggestive of delusions. Pruning backpropagation simulations of speech perception networks produced spontaneous output, which provided a model of auditory hallucination or "voices...
May 1997: M.D. Computing: Computers in Medical Practice
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