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https://www.readbyqxmd.com/read/28814067/neuro-immune-interactions-in-allergic-diseases-novel-targets-for-therapeutics
#1
Tiphaine Voisin, Amélie Bouvier, Isaac M Chiu
Recent studies have highlighted an emerging role for neuro-immune interactions in mediating allergic diseases. Allergies are caused by an overactive immune response to a foreign antigen. The peripheral sensory and autonomic nervous system densely innervates mucosal barrier tissues including the skin, respiratory tract and gastrointestinal (GI) tract that are exposed to allergens. It is increasingly clear that neurons actively communicate with and regulate the function of mast cells, dendritic cells, eosinophils, Th2 cells and type 2 innate lymphoid cells in allergic inflammation...
June 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28812470/oral-administration-of-ovalbumin-after-sensitization-attenuates-symptoms-in-a-mouse-model-of-food-allergic-enteropathy
#2
Erika Hiraide, Mamiko Morinaga, Hiroki Hidaka, Satoki Yamada, Jun Takeyama, Noriko Kitamura, Osamu Kaminuma, Takachika Hiroi, Weibin Du, Katsuyo Ohashi-Doi, Haruyo Nakajima-Adachi, Satoshi Hachimura
Oral immunotherapy (OIT) is a promising treatment of food allergy. To administer an appropriate oral dose of an allergenic component as OIT to individuals sensitized with a food allergen may prevent inducing food allergic inflammation in them. So we attempted to establish a mouse model to evaluate efficacy for oral administration of food allergen after sensitization. In BALB/c mice sensitized by injecting ovalbumin (OVA) with alum twice, OVA was administered before inducing inflammation by feeding the mice with egg white (EW) diet...
August 16, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28811862/allergic-profiles-of-mothers-and-fathers-in-the-japan-environment-and-children-s-study-jecs-a-nationwide-birth-cohort-study
#3
Kiwako Yamamoto-Hanada, Limin Yang, Kazue Ishitsuka, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Testsuo Shoda, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort. METHODS: This study covered a wide geographical area and encompassed 15 regional centers...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28808910/nmr-resonance-assignments-of-a-hypoallergenic-isoform-of-the-major-birch-pollen-allergen-bet-v-1
#4
Linda Ahammer, Sarina Grutsch, Michael Wallner, Fatima Ferreira, Martin Tollinger
In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 occurs as a mixture of various isoforms that possess different immunological properties despite their high sequence identities. Bet v 1.0102 (Bet v 1d), which is investigated here, is a hypoallergenic isoform of Bet v 1 and a potential candidate for allergen-specific immunotherapy...
August 14, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28807539/murine-models-for-mucosal-tolerance-in-allergy
#5
REVIEW
Ursula Smole, Irma Schabussova, Winfried F Pickl, Ursula Wiedermann
Immunity is established by a fine balance to discriminate between self and non-self. In addition, mucosal surfaces have the unique ability to establish and maintain a state of tolerance also against non-self constituents such as those represented by the large numbers of commensals populating mucosal surfaces and food-derived or air-borne antigens. Recent years have seen a dramatic expansion in our understanding of the basic mechanisms and the involved cellular and molecular players orchestrating mucosal tolerance...
August 11, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28804811/serum-diamine-oxidase-in-pseudoallergy-in-the-pediatric-population
#6
Joanna Kacik, Barbara Wróblewska, Sławomir Lewicki, Robert Zdanowski, Bolesław Kalicki
Histamine intolerance (pseudoallergy) is a poorly investigated type of food hypersensitivity. The main enzyme responsible for histamine degradation in the extracellular matrix is diamine oxidase (DAO). Disturbances in the concentration or activity of DAO may lead to the development of clinical signs of allergy. The aim of the present work was to assess the DAO concentration, peripheral blood morphology, lymphocytes phenotyping (CD3+, CD4+, CD8+, CD19+, NK cells, NKT cells, and activated T-cells), and natural regulatory Treg (nTregs) cell population (CD4+, CD25+, CD127low, and FoxP3) in 34 pediatric patients with histamine-dependent syndromes...
August 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28802077/helicobacter-pylori-and-its-secreted-immunomodulator-vaca-protect-against-anaphylaxis-in-experimental-models-of-food-allergy
#7
Andreas Kyburz, Sabine Urban, Aleksandra Altobelli, Stefan Floess, Jochen Huehn, Timothy L Cover, Anne Müller
BACKGROUND: Food allergy is an increasingly common health problem in Western populations. Epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium Helicobacter pylori. OBJECTIVE: The objective of this work was to investigate whether experimental infection with H. pylori, or prophylactic treatment with H. pylori-derived immunomodulatory molecules, affects the onset and severity of food allergy, either positively or negatively...
August 12, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28802031/quality-of-life-among-caregivers-and-growth-in-children-with-parent-reported-food-allergy
#8
Tanya Kajornrattana, Pasuree Sangsupawanich, Araya Yuenyongviwat
BACKGROUND: Some caregivers who believe their children have food allergy avoid feeding certain foods to their children without proper allergy tests. Such actions made without a proper diagnosis can negatively impact the child's health and impose an unnecessary burden on the caregivers. OBJECTIVE: This study aimed to evaluate the caregiver quality of life (QoL) and growth in children with a parent-reported food allergy. METHODS: An observational cross-sectional study was performed in 200 children younger than five years who had a parent-reported food allergy...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28801713/cross-reactivity-profiles-of-legumes-and-tree-nuts-using-the-xmap-%C3%A2-multiplex-food-allergen-detection-assay
#9
Chung Y Cho, Carolyn Oles, William Nowatzke, Kerry Oliver, Eric A E Garber
The homology between proteins in legumes and tree nuts makes it common for individuals with food allergies to be allergic to multiple legumes and tree nuts. This propensity for allergenic and antigenic cross-reactivity means that commonly employed commercial immunodiagnostic assays (e.g., dipsticks) for the detection of food allergens may not always accurately detect, identify, and quantitate legumes and tree nuts unless additional orthogonal analytical methods or secondary measures of analysis are employed...
August 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28801016/adult-onset-food-allergies
#10
REVIEW
Manish Ramesh, Jay A Lieberman
No abstract text is available yet for this article.
August 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28801015/food-allergen-extracts-to-diagnose-food-induced-allergic-diseases-how-they-are-made
#11
Natalie A David, Anusha Penumarti, A Wesley Burks, Jay E Slater
OBJECTIVE: To review the manufacturing procedures of food allergen extracts and applicable regulatory requirements from government agencies, potential approaches to standardization, and clinical application of these products. The effects of thermal processing on allergenicity of common food allergens are also considered. DATA SOURCES: A broad literature review was conducted on the natural history of food allergy, the manufacture of allergen extracts, and the allergenicity of heated food...
August 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28800814/phthalates-impact-human-health-epidemiological-evidences-and-plausible-mechanism-of-action
#12
REVIEW
Sailas Benjamin, Eiji Masai, Naofumi Kamimura, Kenji Takahashi, Robin C Anderson, Panichikkal Abdul Faisal
Disregarding the rising alarm on the hazardous nature of various phthalates and their metabolites, ruthless usage of phthalates as plasticizer in plastics and as additives in innumerable consumer products continues due low their cost, attractive properties, and lack of suitable alternatives. Globally, in silico computational, in vitro mechanistic, in vivo preclinical and limited clinical or epidemiological human studies showed that over a dozen phthalates and their metabolites ingested passively by man from the general environment, foods, drinks, breathing air, and routine household products cause various dysfunctions...
October 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28798526/environmental-pollution-and-allergies
#13
REVIEW
Hirohisa Takano, Ken-Ichiro Inoue
Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28795292/relevance-of-lipophilic-allergens-in-food-allergy-diagnosis
#14
REVIEW
Uta Jappe, Christian Schwager
PURPOSE OF REVIEW: The purpose of this review is to provide available data on a new class of allergens, the oleosins, and their diagnostic value. There is evidence that allergen extracts used for in vivo as well as in vitro diagnostic tests do not contain oleosins because these proteins are lipophilic and nearly insoluble in saline or aqueous solutions. So far, only oleosins of peanut, sesame and hazelnut have been registered as allergens. Reports on IgE-binding tests performed with oleosins of different species with sera from allergic patients show that IgE specific for oleosins are associated with severe allergic reactions which is why they should be part of the diagnostic tests in the future...
August 9, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28792732/integrated-magneto-chemical-sensor-for-on-site-food-allergen-detection
#15
Hsing-Ying Lin, Chen-Han Huang, Jongmin Park, Divya Pathania, Cesar M Castro, Alessio Fasano, Ralph Weissleder, Hakho Lee
Adverse food reactions, including food allergies, food sensitivities, and autoimmune reaction (e.g., celiac disease) affect 5-15% of the population and remain a considerable public health problem requiring stringent food avoidance and epinephrine availability for emergency events. Avoiding problematic foods is practically difficult, given current reliance on prepared foods and out-of-home meals. In response, we developed a portable, point-of-use detection technology, termed integrated Exogenous Antigen Testing (iEAT)...
August 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28792480/the-role-of-nutritional-aspects-in-food-allergy-prevention-and-management
#16
REVIEW
Alessandra Mazzocchi, Carina Venter, Kate Maslin, Carlo Agostoni
The prevalence of food allergy in childhood appears to be increasing in both developed and transitional countries. The aim of this paper is to review and summarise key findings in the prevention and management of food allergy, focusing on the role of dietary components and nutritional habits in the development and optimal functioning of the immune system. Essential fatty acids, zinc and vitamin D are likely to enhance the anti-inflammatory and antioxidative barrier and promote immunologic tolerance. Additionally, nutritional components such as pre- and probiotics represent a novel research approach in the attempt to induce a tolerogenic immune environment...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28791748/evolution-of-the-ige-and-igg-repertoire-to-a-comprehensive-array-of-allergen-molecules-in-the-first-decade-of-life
#17
Xinyuan Huang, Olympia Tsilochristou, Serena Perna, Stephanie Hofmaier, Antonio Cappella, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Raffaele D'Amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
BACKGROUND: In early childhood, the allergen-specific IgG repertoire is mainly directed to animal and vegetable food molecules and infrequently to airborne molecules. It is unknown whether this early pattern is maintained throughout childhood. OBJECTIVE: To investigate the evolution of IgG and IgE responses to a broad panel of allergenic molecules from birth to age 10yrs. METHODS: We examined the sera collected between birth and age 10yrs from participants in the German Multicentre Allergy Study, a birth cohort born in 1990...
August 8, 2017: Allergy
https://www.readbyqxmd.com/read/28789818/windows-of-opportunity-for-tolerance-induction-for-allergy-by-studying-the-evolution-of-allergic-sensitization-in-birth-cohorts
#18
REVIEW
Marit Westman, Anna Asarnoj, Carl Hamsten, Magnus Wickman, Marianne van Hage
Allergic sensitization is a risk factor for developing IgE-mediated allergic diseases, which are a major cause of chronic illness world-wide. The introduction of allergen molecules to the field of allergy diagnostics has allowed dissecting the IgE response on a molecular level to pinpoint the specific disease-causing allergens. Studying birth cohorts is an essential tool for understanding the development and life course of allergy, enabling the possibility to design preventive strategies. Here we review the evolution of sensitization using data from some of the large European birth cohort studies...
August 5, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28783056/diet-quality-throughout-early-life-in-relation-to-allergic-sensitization-and-atopic-diseases-in-childhood
#19
Anh N Nguyen, Niels J Elbert, Suzanne G M A Pasmans, Jessica C Kiefte-de Jong, Nicolette W de Jong, Henriëtte A Moll, Vincent W V Jaddoe, Johan C de Jongste, Oscar H Franco, Liesbeth Duijts, Trudy Voortman
Early-life nutrition is an important modifiable determinant in the development of a child's immune system, and may thereby influence the risk of allergic sensitization and atopic diseases. However, associations between overall dietary patterns and atopic diseases in childhood remain unclear. We examined associations of diet quality in early life with allergic sensitization, self-reported physician-diagnosed inhalant and food allergies, eczema, and asthma among 5225 children participating in a population-based cohort in the Netherlands...
August 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28782634/a-new-allergen-family-involved-in-pollen-food-associated-syndrome-snakin-gibberellin-regulated-proteins
#20
Hélène Sénéchal, Jiří Šantrůček, Magdalena Melčová, Petr Svoboda, Jarmila Zídková, Denis Charpin, Laurence Guilloux, Youcef Shahali, Marie-Ange Selva, Rémy Couderc, Tomoyasu Aizawa, Pascal Poncet
At least two pollen food associated syndromes were described with cypress pollen allergy involving peach and citrus. Snakin/gibberellin regulated proteins are described herein to be the cross-reactive allergens between Cupressus sempervirens pollen and fruit/vegetables.
August 3, 2017: Journal of Allergy and Clinical Immunology
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