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https://www.readbyqxmd.com/read/29785006/the-era-of-immunogenomics-immunopharmacogenomics
#1
REVIEW
Makda Zewde, Kazuma Kiyotani, Jae-Hyun Park, Hua Fang, Kai Lee Yap, Poh Yin Yew, Houda Alachkar, Taigo Kato, Tu H Mai, Yuji Ikeda, Tatsuo Matsuda, Xiao Liu, Lili Ren, Boya Deng, Makiko Harada, Yusuke Nakamura
Although germline alterations and somatic mutations in disease cells have been extensively analyzed, molecular changes in immune cells associated with disease conditions have not been characterized in depth. It is clear that our immune system has a critical role in various biological and pathological conditions, such as infectious diseases, autoimmune diseases, drug-induced skin and liver toxicity, food allergy, and rejection of transplanted organs. The recent development of cancer immunotherapies, particularly drugs modulating the immune checkpoint molecules, has clearly demonstrated the importance of host immune cells in cancer treatments...
May 21, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29783251/prevalence-of-risk-factors-of-allergic-diseases-among-children-aged-8-9-years-in-poltava-region-the-results-of-the-first-stage-of-the-research
#2
Tetyana O Kryuchko, Iryna A Holovanova, Olha Y Tkachenko, Mariya O Melnyk, Kateryna V Pocheniuk
OBJECTIVE: Introduction: According to the European Academy of Allergology and Clinical Immunology (EAACI, 2016), allergy is the most common chronic disease in Europe. The aim: The aim of the investigation is to study the spread of risk factors of allergic reactions in children who are 8-9 years old of Poltava region. PATIENTS AND METHODS: Materials and methods: The investigation included two stages: the 1st contained interviewing; the 2nd one - additional clinical and lab investigation of children, who require the further diagnosis specification...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29780153/food-specific-iggs-are-highly-increased-in-the-sera-of-patients-with-inflammatory-bowel-disease-and-are-clinically-relevant-to-the-pathogenesis
#3
Nanping Xiao, Fenghua Liu, Guangxi Zhou, Mingming Sun, Fengfu Ai, Zhanju Liu
Objective Dietary antigens are common luminal antigens in the gastrointestinal tract and have been considered to contribute to the pathogenesis of inflammatory bowel disease (IBD). We analyzed the levels of food-specific IgGs against a variety of dietary antigens, explored the clinical relevance of food allergy to the pathogenesis of IBD, and investigated whether or not infliximab (IFX) treatment could regulate the immune responses induced by dietary antigens. Methods A total of 301 IBD patients, including 201 patients with Crohn's disease (CD) and 100 patients with ulcerative colitis (UC), were recruited, and their serum food-specific IgGs against 14 food antigens were detected by a semi-quantitative enzyme linked immunosorbent assay (ELISA)...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779209/gata3-hypermethylation-and-foxp3-hypomethylation-are-associated-with-sustained-protection-and-bystander-effect-following-epicutaneous-immunotherapy-in-peanut-sensitized-mice
#4
Lucie Mondoulet, Vincent Dioszeghy, Florence Busato, Camille Plaquet, Véronique Dhelft, Kevin Bethune, Laurence Leclere, Christian Daviaud, Mélanie Ligouis, Hugh Sampson, Christophe Dupont, Jörg Tost
BACKGROUND: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kinetics of DNA methylation changes in sorted cells from spleen and blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT). METHODS: BALB/c mice orally sensitized to peanut proteins (PPE) were treated by EPIT using a PPE-patch or by PPE-OIT...
May 19, 2018: Allergy
https://www.readbyqxmd.com/read/29778497/food-groups-for-allergen-risk-assessment-combining-food-consumption-data-from-different-countries-in-europe
#5
Sophie Birot, Charlotte B Madsen, Astrid G Kruizinga, Amélie Crépet, Tue Christensen, Per B Brockhoff
To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan-European food data suitable for food allergy risk assessment. The aim of this paper is to investigate if consumption data, at a meal level, from National Food Consumption Surveys, can be combined to form a common Food Consumption database...
May 17, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29778476/glycation-of-whey-protein-with-dextrans-of-different-molar-mass-effect-on-immunoglobulin-e-binding-capacity-with-blood-sera-obtained-from-patients-with-cow-milk-protein-allergy
#6
Lei Xu, Yuansheng Gong, James E Gern, Shinya Ikeda, John A Lucey
A growing concern around the world is the number of people who are suffering from food protein allergies. One potential approach to decrease protein allergenicity is to block IgE-binding epitopes of the protein allergen by attachment of polysaccharides via the Maillard reaction (i.e., glycation). Protein glycation has been extensively studied to modify various functional properties. We wanted to examine whether glycates could reduce IgE binding in patients with cow milk protein allergy and to explore how the size (molar mass; MW ) of the polysaccharide affects this IgE-binding capacity...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29777733/food-allergy-guidance-in-the-united-states-military-a-work-group-report-from-the-aaaai-military-allergy-and-immunology-assembly-maia
#7
Kirk Waibel, Rachel Lee, Christopher Coop, Yun Mendoza, Kevin White
A diagnosis of food allergy adversely impacts one's ability to join or remain in the military. Inadequate knowledge or misconceptions of current military-specific standards regarding food allergy and how these apply to enlistment, induction, and retention in the United States military can potentially lead to inaccurate counseling as each military service has specific regulations which impact the evaluation and decision-making process. Recognizing this knowledge gap, the American Allergy, Asthma, and Immunology (AAAAI) Military Allergy and Immunology Assembly (MAIA) established a Work Group who reviewed and summarized all aspects of military instructions, policies, and regulations regarding IgE mediated food allergy...
May 16, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29777628/allergy-in-the-elderly-case-note-review
#8
N J Gray, E L Redshaw, D Isaacs, M D Tarzi, H E Smith, A J Frew
The prevalence of IgE-mediated disease increased significantly during the 20th century. In developed countries, about 20% of people have atopic disease, which consumes significant amounts of healthcare funding. For example, in UK general practice, allergic conditions account for 6% of consultations and ~10% of prescribing costs [1]. Whilst most studies of allergy focus on children and adolescents, relatively little has been written about allergy in older people, although food allergy may be increasingly common in this group [2]...
May 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29774370/il-33-s-st2-ratio-systemic-symptoms-and-basophil-activation-in-pru-p-3-sensitized-allergic-patients
#9
Carina G Uasuf, Caterina Di Sano, Sebastiano Gangemi, Giuseppe Albeggiani, Diego Cigna, Paola Dino, Ignazio Brusca, Mark Gjomarkaj, Elisabetta Pace
BACKGROUND: Although IL-33/ST2 axis is involved in the development of allergic diseases, its contribution in food allergy is still unknown. METHODS: In this study, we assessed the serum levels of IL-33 and its s-ST2 receptor in 53 control patients (without allergic diseases), 47 peach (Pru p 3)-sensitized allergic patients (SAP), and in 68 non-Pru p 3-SAP. Basophil activation test (BAT) was used to assess the basophil activation due to allergen exposure before and after the addition of s-ST2 to the blood samples from 5 Pru p 3-SAP...
May 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29773698/protocol-for-the-validation-of-sensitivity-and-specificity-of-the-cow-s-milk-related-symptom-score-comiss-against-open-food-challenge-in-a-single-blinded-prospective-multicentre-trial-in-infants
#10
Yvan Vandenplas, Rajat Mukherjee, Christophe Dupont, Philippe Eigenmann, Arne Høst, Mikael Kuitunen, Carmen Ribes-Koninkx, Neil Shah, Hania Szajewska, Andrea von Berg, Ralf G Heine, Zheng-Yan Zhao
INTRODUCTION: The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29772091/sensitisation-to-outdoor-and-indoor-fungi-in-atopic-dermatitis-patients-and-the-relation-to-the-occurrence-of-food-allergy-to-peanuts-and-walnuts
#11
J Čelakovská, J Bukač, K Ettler, J Vaneckova, K Ettlerova, J Krejsek
The aim of this study is the evaluation of the relation between the sensitisation to outdoor and indoor fungi and allergy to peanuts and walnuts in atopic dermatitis patients aged 14 years and older. The complete dermatological and allergological examinations were perfomed in all included patients; the occurrence of food allergy to peanuts and walnuts was recorded (specific IgE, skin prick test, history of allergic reaction) and the sensitisation to mixture of outdoor fungi and indoor fungi was examined (skin prick test, specific IgE)...
May 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29771760/cutaneous-manifestations-of-nutritional-deficiency
#12
Ramrada Lekwuttikarn, Joyce M C Teng
PURPOSE OF REVIEW: Childhood malnutrition is a major global health issue. It is often thought of as a developing world problem and therefore, underdiagnosed or misdiagnosed in developed countries. The delay in diagnosis and treatment can lead to increased morbidity and mortality. Cutaneous manifestations are often the initial presenting signs of nutritional deficiency. Early recognition is essential in timely initiation of the necessary interventions. This article will review pertinent cutaneous findings and systemic manifestations associated with common nutritional deficiencies...
May 15, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29769472/-evaluation-of-the-effectiveness-of-subcutaneous-immunotherapy-using-birch-pollen-extract-for-pollen-food-allergy-syndrome
#13
Shuntaro Tsumagari, Satomi Mori, Hiroko Ishizu, Yutaka Tanaka, Yoshihisa Okamoto, Kazuyuki Kurihara
BACKGROUNDS: Recently, patients with oral allergy syndrome (OAS) to fruits or vegetables caused by pollenfood allergy syndrome (PFAS) have increased nationwide. We examined effectiveness of SCIT using birch pollen extract for PFAS. METHODS: A total of 19 patients (9 male and 10 female) underwent SCIT with birch pollen extract from August 2011 to August 2016. Rush schedule was used for the initial updosing for SCIT in a hospital setting. In maintenance phase, SCIT was administered every 4-8 weeks on an outpatient basis...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29769471/-ministry-of-health-2015-penultimate-year-children-and-survey-and-research-project-promoting-the-parenting-support-actual-conditions-report-on-the-results-of-the-investigation-on-allergy-control-in-day-care-centers-admissions-children-of-allergic-diseases-situation
#14
Noriyuki Yanagida, Motohiro Ebisawa, Toshio Katsunuma, Jyoji Yoshizawa
BACKGROUND: There are no reports on the prevalence and social acceptance of food allergies (FAs) and FAinduced symptoms in nursery schools in Japan. PURPOSE: The purpose of this study is to clarify the current status of FA among children in nurseries. METHODS: Investigations were conducted in childcare facilities nationwide through survey request forms found on the Web page or sent via post. RESULT: We received responses from 15722 out of the 32210 institutions (48...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29767340/speculation-as-to-why-the-frequency-of-eosinophilic-esophagitis-is-increasing
#15
REVIEW
Stuart Jon Spechler
PURPOSE OF REVIEW: The frequency of eosinophilic esophagitis (EoE), an immune/antigen-mediated disorder first described in 1993, has been increasing rapidly. The purpose of this review is to consider hypotheses proposed to explain this increase and to speculate on their validity. RECENT FINDINGS: The hygiene hypothesis attributes the rise of EoE to modern hygienic conditions resulting in fewer childhood infections with microbes that might have protected against allergy development...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#16
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29764625/recognition-of-phenylthiocarbamide-ptc-in-taste-test-is-related-to-blood-group-b-phenotype-females-and-risk-of-developing-food-allergy-a-cross-sectional-brazilian-based-study
#17
Isac César Roldão Leite, José Carlos Dos Santos Júnior, Cinthya Clara Silva de Sousa, Alexandre Vasconcelos Lima, Ana Luisa Miranda-Vilela
Anti-nutritional factors, including hemagglutinins, are natural substances that reduce nutritional bioavailability and/or generate adverse physiological effects. Most are bitter toxic compounds, but present chemo-protective properties at low concentrations. Responses to phenylthiocarbamide (PTC) allow for an evaluation of humans' perception of bitter taste, a perception that has evolutionary advantages. Therefore, we hypothesized that relationships between food preference, dietary exposures and disease risk could reflect possible associations not only with the recognition threshold for the bitter taste of PTC, but also with ABO/Rh blood group phenotypes...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29763349/molar-incisor-hypomineralization-positive-correlation-with-atopic-dermatitis-and-food-allergies
#18
Miguel Hernandez, Juan Boj, Enric Espasa, Paloma Planells, Benjamin Peretz
AIM: Molar-incisor hypomineralization is a disturbance in dental development that involves first permanent molars as well as permanent incisors with a prevalence that ranges from 2.5% to 40%. The objective of this study was to investigate the etiology of molar-incisor hypomineralization among school children from two randomly selected towns in the province of Barcelona, Spain. STUDY DESIGN: A cross-sectional study was conducted with 705 children ranging in age from six years-old to 14 years and 11 months-old...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29763312/deep-sea-derived-butyrolactone-i-suppresses-ovalbumin-induced-anaphylaxis-by-regulating-mast-cell-function-in-a-murine-model
#19
Qingmei Liu, Chun-Lan Xie, Yuanyuan Gao, Bo Liu, Weixiang Lin, Hong Liu, Min-Jie Cao, Wen-Jin Su, Xianwen Yang, Guang-Ming Liu
Deep-sea-derived butyrolactone I (BTL-I) which was identified as a type of butanolide was isolated from Aspergillus sp. Ovalbumin (OVA)-induced BALB/c anaphylaxis was established to explore the anti-food allergic activity of BTL-I. As results, BTL-I was able to alleviate OVA-induced allergy symptoms, reduce the levels of histamine and mouse mast cell proteinases, inhibit OVA-specific IgE, and decrease the population of mast cells in the spleen and mesenteric lymph nodes. BTL-I also significantly suppressed mast-dependent passive cutaneous anaphylaxis...
May 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29762879/eosinophilic-esophagitis-latest-insights-from-diagnosis-to-therapy
#20
REVIEW
Alain Schoepfer, Carine Blanchard, Heather Dawson, Alfredo Lucendo, Aurelio Mauro, Camillo Ribi, Ekaterina Safroneeva, Edoardo V Savarino, Roberto Penagini
Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011...
May 15, 2018: Annals of the New York Academy of Sciences
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