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https://www.readbyqxmd.com/read/28917655/inactivation-of-tnf-lt-locus-alters-mouse-metabolic-response-to-concentrated-ambient-pm2-5
#1
Ziying Hu, Minjie Chen, Huifen Zhou, Anui Tharakan, Xiaoke Wang, Lianglin Qiu, Shuai Liang, Xiaobo Qin, Yuhao Zhang, Wanjun Wang, Yanyi Xu, Zhekang Ying
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2.5 exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNFα), lymphotoxin α (LTα), and lymphotoxin β (LTβ) are three homologous pro-inflammatory cytokines, each with both unique and redundant activities in inflammation. Their role in PM2.5 exposure-induced inflammation and adverse cardiometabolic effects has to be determined...
September 13, 2017: Toxicology
https://www.readbyqxmd.com/read/28917235/reconfirmation-of-improved-tolerance-to-a-new-amino-acid-based-formula-by-infants-with-cow-s-milk-protein-allergy
#2
Pipop Jirapinyo, Narumon Densupsoontorn, Channagan Kangwanpornsiri, Renu Wongarn, Hathaichanok Tirapongporn, Kwanjai Chotipanang, Phakkanan Phuangphan
BACKGROUND AND OBJECTIVES: Reasons for intolerance to commercial amino acid-based formulas (cAAF) in infants diagnosed with cow's milk protein allergy (CMA) remain unknown. We assume that minute amounts of proteins, presenting in the glucose polymers derived from corn starch (cGPs), can elicit the intolerance to the cAAFs observed in some infants with CMA. By replacing cGPs with glucose polymers derived from rice starch (rGPs), a new amino acid-based (nAAF) formula has been shown to be better tolerated than an existing cAAF...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28903914/long-term-treatment-with-the-ghrelin-receptor-antagonist-d-lys3-ghrp-6-does-not-improve-glucose-homeostasis-in-non-obese-diabetic-mkr-mice
#3
Rasha Mosa, Lili Huang, Hongzhuo Li, Michael Grist, Derek LeRoith, Chen Chen
Ghrelin secretion has been associated with increased caloric intake and adiposity. The expressions of ghrelin and its receptor (GHS-R1a) in pancreas have raised the interest about the role of ghrelin in glucose homeostasis. Most of the studies showed that ghrelin promoted hyperglycaemia and inhibited insulin secretion. This raised the interest in using GHS-R1a antagonists as therapeutic targets for type 2 diabetes. Available data of GHS-R antagonists are on a short-term basis. Moreover, the complexity of GHS-R1a signalling makes it difficult to understand the mechanism of action of GHS-R1a antagonists...
September 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28884564/pattern-of-food-intolerance-in-patients-with-gastro-esophageal-reflux-symptoms
#4
Michele Caselli, Natalina Lo Cascio, Stefano Rabitti, Leonardo H Eusebi, Elena Zeni, Cecilia Soavi, Francesca Cassol, Giovanni Zuliani, Rocco M Zagari
BACKGROUND: Many food items have been involved in gastro-esophageal reflux disease pathogenesis and dietary modification has been proposed as first-line treatment. Test-based exclusion diets have shown to significantly reduce reflux symptoms. we aimed to assess the patterns of food intolerance in a series of patients with typical gastro-esophageal reflux symptoms (GERS). METHODS: We retrospectively evaluated all patients with typical reflux symptoms, attending the Centre Study Association on Food Intolerance and Nutrition of Ferrara from January 2010 to October 2015, who resulted positive to at least one food item at the leucocytotoxic test...
September 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28874461/selective-deletion-of-renin-b-in-the-brain-alters-drinking-and-metabolism
#5
Keisuke Shinohara, Pablo Nakagawa, Javier Gomez, Donald A Morgan, Nicole K Littlejohn, Matthew D Folchert, Benjamin J Weidemann, Xuebo Liu, Susan A Walsh, Laura L Ponto, Kamal Rahmouni, Justin L Grobe, Curt D Sigmund
The brain-specific isoform of renin (Ren-b) has been proposed as a negative regulator of the brain renin-angiotensin system (RAS). We analyzed mice with a selective deletion of Ren-b which preserved expression of the classical renin (Ren-a) isoform. We reported that Ren-b(Null) mice exhibited central RAS activation and hypertension through increased expression of Ren-a, but the dipsogenic and metabolic effects in Ren-b(Null) mice are unknown. Fluid intake was similar in control and Ren-b(Null) mice at baseline and both exhibited an equivalent dipsogenic response to deoxycorticosterone acetate-salt...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28871516/stability-and-change-in-in-group-mate-preferences-among-young-people-in-ethiopia-are-predicted-by-food-security-and-gender-attitudes-but-not-by-expected-pathogen-exposures
#6
Craig Hadley, Daniel Hruschka
There is broad anthropological interest in understanding how people define "insiders" and "outsiders" and how this shapes their attitudes and behaviors toward others. As such, a suite of hypotheses has been proposed to account for the varying degrees of in-group preference between individuals and societies. We test three hypotheses related to material insecurity, pathogen stress, and views of gender equality among cross-sectional (n = 1896) and longitudinal (n = 1002) samples of young people in Ethiopia (aged 13-17 years at baseline) to explore stability and change in their preferences for coethnic spouses...
September 4, 2017: Human Nature: An Interdisciplinary Biosocial Perspective
https://www.readbyqxmd.com/read/28867793/diet-gut-microbiome-and-epigenetics-emerging-links-with-inflammatory-bowel-diseases-and-prospects-for-management-and-prevention
#7
REVIEW
Krasimira Aleksandrova, Beatriz Romero-Mosquera, Vicent Hernandez
Inflammatory bowel diseases (IBD) represent a growing public health concern due to increasing incidence worldwide. The current notion on the pathogenesis of IBD is that genetically susceptible individuals develop intolerance to dysregulated gut microflora (dysbiosis) and chronic inflammation develops as a result of environmental triggers. Among the environmental factors associated with IBD, diet plays an important role in modulating the gut microbiome, influencing epigenetic changes, and, therefore, could be applied as a therapeutic tool to improve the disease course...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28865210/clinical-efficacy-of-nutraceutical-diet-for-cats-with-clinical-signs-of-cutaneus-adverse-food-reaction-cafr
#8
F Mazzeranghi, C Zanotti, A Di Cerbo, J P Verstegen, R Cocco, G Guidetti, S Canello
Food allergies and food intolerances are clinically difficult to discriminate. Most often, along with cutaneous adverse food reactions or CAFR, they are classified as adverse food reactions, whose causes are numerous, including toxic compounds. Eighteen indoor-housed domestic cats with evident clinical symptoms related to CAFR (drooling, back and neck intense itching, neck eczema, chronic conjunctivitis and stomatitis) involving skin lesions were studied. Cytological evaluations of ear, skin and gingival swabs revealed an increased turnover of keratinocytes while the oxytetracycline ELISA determination showed an unexpected high amount of oxytetracycline in all cats at the first visit...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28860789/new-developments-in-the-treatment-of-primary-biliary-cholangitis-role-of-obeticholic-acid
#9
REVIEW
Manan A Jhaveri, Kris V Kowdley
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease that predominantly affects women in early to middle age. It is typically associated with autoantibodies to mitochondrial antigens and results in immune-mediated destruction of small and medium-sized intrahepatic bile ducts leading to cholestasis, hepatic fibrosis and may progress to cirrhosis or hepatic failure and, in some cases, hepatocellular carcinoma. The clinical presentation and the natural history of PBC have improved over the years due to recognition of earlier widespread use of ursodeoxycholic acid (UDCA); about one-third of patients show suboptimal biochemical response to UDCA with poor prognosis...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28857322/new-insights-into-structural-organization-and-gene-duplication-in-a-1-75-mb-genomic-region-harboring-the-%C3%AE-gliadin-gene-family-in-aegilops-tauschii-the-source-of-wheat-d-genome
#10
Naxin Huo, Lingli Dong, Shengli Zhang, Yi Wang, Tingting Zhu, Toni Mohr, Susan Altenbach, Zhiyong Liu, Jan Dvorak, Olin D Anderson, Ming-Cheng Luo, Daowen Wang, Yong Q Gu
Among the wheat prolamins important for its end-use traits, α-gliadins are the most abundant and also a major cause of food-related allergies and intolerances. Previous studies of various wheat species estimated between 25 to 150 α-gliadin genes reside in the Gli-2 locus regions. To better understand the evolution of this complex gene family, the DNA sequence of a 1.75-Mb genomic region spanning the Gli-2 locus was analyzed in the diploid grass, Aegilops tauschii, the ancestral source of D genome in hexaploid bread wheat...
August 30, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28840471/the-effects-of-duodenojejunal-omega-switch-in-combination-with-high-fat-diet-and-control-diet-on-incretins-body-weight-and-glucose-tolerance-in-sprague-dawley-rats
#11
Dominika Stygar, Tomasz Sawczyn, Bronisława Skrzep-Poloczek, Aleksander J Owczarek, Natalia Matysiak, Marek Michalski, Łukasz Mielańczyk, Barbara Bażanów, Paweł Ziora, Piotr Choręza, Bogdan Doleżych, Konrad Wojciech Karcz
BACKGROUND: Despite excellent results of bariatric surgery in the treatment of type 2 diabetes and weight loss in human subjects, some patients do not obtain desired results. One of the reasons for this is that not all patients follow caloric intake recommendations. AIM: The aim of this study was to investigate the effect of duodenojejunal omega switch (DJOS) surgery on body weight, glucose tolerance, and incretins in rats. METHODS: DJOS and SHAM surgery were performed on rats maintained for 8 weeks on high-fat diet (HF) and control diet (CD), respectively...
August 24, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28838129/reduced-tolerance-to-night-shift-in-chronic-shift-workers-insight-from-fractal-regulation
#12
Peng Li, Christopher J Morris, Melissa Patxot, Tatiana Yugay, Joseph Mistretta, Taylor E Purvis, Frank A J L Scheer, Kun Hu
Study Objectives: Healthy physiology is characterized by fractal regulation (FR) that generates similar structures in the fluctuations of physiological outputs at different time scales. Perturbed FR is associated with aging and age-related pathological conditions. Shift work, involving repeated and chronic exposure to misaligned environmental and behavioral cycles, disrupts circadian coordination. We tested whether night shifts perturb FR in motor activity and whether night shifts affect FR in chronic shift workers and non-shift workers differently...
July 1, 2017: Sleep
https://www.readbyqxmd.com/read/28832911/different-strategies-for-diagnosing-gestational-diabetes-to-improve-maternal-and-infant-health
#13
REVIEW
Diane Farrar, Lelia Duley, Therese Dowswell, Debbie A Lawlor
BACKGROUND: Gestational diabetes mellitus (GDM) is carbohydrate intolerance resulting in hyperglycaemia with onset or first recognition during pregnancy. If untreated, perinatal morbidity and mortality may be increased. Accurate diagnosis allows appropriate treatment. Use of different tests and different criteria will influence which women are diagnosed with GDM. This is an update of a review published in 2011 and 2015. OBJECTIVES: To evaluate and compare different testing strategies for diagnosis of gestational diabetes mellitus to improve maternal and infant health while assessing their impact on healthcare service costs...
August 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28820648/natural-bioactive-food-components-for-improving-enteral-tube-feeding-tolerance-in-adult-patient-populations
#14
Adam J Kuchnia, Beth Conlon, Norman Greenberg
Tube feeding (TF) is the most common form of nutrition support. In recent years, TF administration has increased among patient populations within and outside hospital settings, in part due to greater insurance coverage, reduced use of parenteral nutrition, and improved formularies suitable for sole source nutrition. With increasing life expectancy and improved access to TFs, the number of adults dependent on enteral nutrition is expected to grow. However, enteral TF intolerance (ETFI) is the most common complication of TFs, typically presenting with at least 1 adverse gastrointestinal event, including nausea, diarrhea, and constipation...
August 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28811359/exercise-training-prevents-skeletal-muscle-plasma-membrane-cholesterol-accumulation-cortical-actin-filament-loss-and-insulin-resistance-in-c57bl-6j-mice-fed-a-western-style-high-fat-diet
#15
Ashley G Ambery, Lixuan Tackett, Brent A Penque, Joseph T Brozinick, Jeffrey S Elmendorf
Insulin action and glucose disposal are enhanced by exercise, yet the mechanisms involved remain imperfectly understood. While the causes of skeletal muscle insulin resistance also remain poorly understood, new evidence suggest excess plasma membrane (PM) cholesterol may contribute by damaging the cortical filamentous actin (F-actin) structure essential for GLUT4 glucose transporter redistribution to the PM upon insulin stimulation. Here, we investigated whether PM cholesterol toxicity was mitigated by exercise...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28804811/serum-diamine-oxidase-in-pseudoallergy-in-the-pediatric-population
#16
Joanna Kacik, Barbara Wróblewska, Sławomir Lewicki, Robert Zdanowski, Bolesław Kalicki
Histamine intolerance (pseudoallergy) is a poorly investigated type of food hypersensitivity. The main enzyme responsible for histamine degradation in the extracellular matrix is diamine oxidase (DAO). Disturbances in the concentration or activity of DAO may lead to the development of clinical signs of allergy. The aim of the present work was to assess the DAO concentration, peripheral blood morphology, lymphocytes phenotyping (CD3+, CD4+, CD8+, CD19+, NK cells, NKT cells, and activated T-cells), and natural regulatory Treg (nTregs) cell population (CD4+, CD25+, CD127low, and FoxP3) in 34 pediatric patients with histamine-dependent syndromes...
August 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28775227/immunoglobulin-g-testing-in-the-diagnosis-of-food-allergy-and-intolerance
#17
T H Lee, Y Y Wu, J Kc Chan, H K Ho, P H Li, J Sd Rosa Duque
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28760081/plasma-concentrations-of-ascorbic-acid-in-a-cross-section-of-the-german-population
#18
Alexander F Hagel, Heinz Albrecht, Wolfgang Dauth, Wolfgang Hagel, Francesco Vitali, Ingo Ganzleben, Hans W Schultis, Peter C Konturek, Jürgen Stein, Markus F Neurath, Martin Raithel
Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant-patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28740397/eligibility-for-alirocumab-or-evolocumab-treatment-in-1090-hypercholesterolemic-patients-referred-to-a-regional-cholesterol-treatment-center-with-ldl-cholesterol-%C3%A2-70-mg-dl-despite-maximal-tolerated-ldl-cholesterol-lowering-therapy
#19
Vybhav Jetty, Charles J Glueck, Kevin Lee, Naila Goldenberg, Marloe Prince, Ashwin Kumar, Michael Goldenberg, Ishan Anand, Ping Wang
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 inhibitors, Praluent (alirocumab [ALI]) and Repatha (evolocumab [EVO]) have been approved as adjuncts to the standard-of-care maximal-tolerated dose (MTD) of low-density lipoprotein cholesterol (LDLC)-lowering therapy (LLT), statin therapy, in heterozygous (HeFH) (ALI or EVO) or homozygous (EVO) familial hypercholesterolemia, or clinical atherosclerotic cardiovascular disease (CVD) where LDLC lowering is insufficient (both). Since LDLC lowering has been revolutionized by ALI and EVO, specialty pharmaceutical pricing models will be applied to a mass market...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28738753/genetic-predictors-of-celiac-disease-lactose-intolerance-and-vitamin-d-function-and-presence-of-peptide-morphins-in-urine-of-children-with-neurodevelopmental-disorders
#20
Katarina Bojović, Biljana Stanković, Nikola Kotur, Dijana Krstić-Milošević, Vladimir Gašić, Sonja Pavlović, Branka Zukić, Đurđica Ignjatović
Gastrointestinal disturbances, nutritional deficiencies, and food intolerances are frequently observed in children with neurodevelopmental disorders (NDD). To reveal possible association of celiac disease risk variants (HLA-DQ), lactose intolerance associated variant (LCT-13910C>T) as well as variant associated with vitamin D function (VDR FokI) with NDD, polymerase chain reaction-based methodology was used. Additionally, intestinal peptide permeability was estimated in NDD patients and healthy children by measuring the level of peptides in urine using high-performance liquid chromatography...
July 24, 2017: Nutritional Neuroscience
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