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Hsiao-Feng Chou, Yu-Hung Wu, Che-Sheng Ho, Yu-Hsuan Kao
BACKGROUND: This study aimed to evaluate the demographic, clinical features, laboratory data, pathology and other survey in pediatric patients with cryofibrinogenemia. METHODS: A 12-year retrospective chart review identified eight pediatric patients at Mackay Memorial Hospital, Taipei, Taiwan. RESULTS: The female-to-male ratio was 3:1. The mean age at symptom onset and of diagnosis was 10.3 ± 4.6 years and 12.3 ± 4 years, respectively...
April 24, 2018: Pediatric Rheumatology Online Journal
Jane Greening, Kamakshi Anantharaman, Rupert Young, Andrew Dilley
Study Design Cross-sectional study. Background Whiplash following a motor vehicle accident can result in chronic neck and arm pain. Patients frequently present with cutaneous hypersensitivities and hypoesthesia but without obvious clinical sign of nerve injury. T2-weighted magnetic resonance imaging (MRI) has previously been used to identify nerve pathology. Objectives To determine whether there are signs of peripheral nerve pathology on MRI in patients with chronic arm and neck pain following whiplash injury...
April 24, 2018: Journal of Orthopaedic and Sports Physical Therapy
Yoon-Sook Lee, Woon Young Kim, Ji Won Yoo, Hyun Don Jung, Too Jae Min
Background: Cardiopulmonary bypass (CPB) can cause systemic hypoperfusion, which remains undetected by routine monitoring of physiological parameters. Noninvasive tissue perfusion monitoring offers a clinical benefit by detecting low systemic perfusion. In this study, we tried to evaluate whether regional tissue perfusion saturation reflects systemic hypoperfusion during CPB. Methods: This retrospective study included 29 patients with American Society of Anesthesiologists physical status II-III, who required cardiac surgery with CPB...
April 25, 2018: Korean Journal of Anesthesiology
Y C Liang, Y P Wu, H Cai, S H Cheng, Y Wei, X Y Xue, Q S Zheng, J B Huang, Y Z Lin, N Xu
Objective: To determine the influence of urethral fibrosis on the recovery of urinary continence after laparoscopic radical prostatectomy. Method: A retrospective study of 203 patients from January 2010 to January 2014 who were underwent laparoscopic radical prostatectomy for prostate cancer in the First Affiliated Hospital of Fujian Medical University. The patients were divided into 2 groups according to preoperative T2-weighted magnetic resonance imaging of fibrosis status of the urethral wall and periurethral tissue...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Mohammad Asaduzzaman, Martin Kerschbaumer, Matteo Scampicchio
RATIONALE: A rapid and non-invasive method for the control of milk by proton transfer reaction mass spectrometry was developed. The approach has the potential to verify the geographic origin and altitude of dairy farms, provided that the cows were extensively grazed with forage that reflects the botanical composition of the mountain environment. METHODS: Over a month period, a total of 116 samples were analysed by proton transfer reaction mass spectrometry (PTRMS)...
April 24, 2018: Rapid Communications in Mass Spectrometry: RCM
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner...
April 21, 2018: Acta Biomaterialia
Ambrosina Michelotti, Roberto Rongo, Roberta Valentino, Vincenzo D'Antò, Rosaria Bucci, Gianluca Danz, Iacopo Cioffi
Objectives: The relationship between unilateral posterior crossbite (UPCB) and the possible asymmetric activation of the jaw muscles in children is still under debate. This study aimed at evaluating the jaw muscle activity of children with UPCB before and after rapid maxillary expansion (RME) by means of surface electromyography and a standardized sampling protocol. Subjects and methods: Twenty-nine children with UPCB (UPCB-group, mean age 9.6 ± 1.6 years) and 40 UPCB-free controls (Control-group, 10...
April 23, 2018: European Journal of Orthodontics
Kelly C McPhee, Alan H Wilman
BACKGROUND: Exponential fitting of multiecho spin echo sequences with skipped echoes is still commonly used for quantification of transverse relaxation (T2 ). PURPOSE: To examine the efficacy of skipped echo methods for T2 quantification against computational modeling of the exact signal decay. STUDY TYPE: Prospective comparison of methods. SUBJECTS/PHANTOM: Eight volunteers were imaged at 4.7T, six volunteers at 1.5T, and phantoms ([MnCl2 ] = 68-270 mM)...
April 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
Olli Nykänen, Lassi Rieppo, Juha Töyräs, Ville Kolehmainen, Simo Saarakkala, Karin Shmueli, Mikko J Nissi
PURPOSE: We investigated the feasibility of quantitative susceptibility mapping (QSM) for assessing degradation of articular cartilage by measuring ex vivo bovine cartilage samples subjected to different degradative treatments. Specimens were scanned at several orientations to study if degradation affects the susceptibility anisotropy. T2*-mapping, histological stainings, and polarized light microscopy were used as reference methods. Additionally, simulations of susceptibility in layered geometry were performed...
April 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Congbo Cai, Chao Wang, Yiqing Zeng, Shuhui Cai, Dong Liang, Yawen Wu, Zhong Chen, Xinghao Ding, Jianhui Zhong
PURPOSE: An end-to-end deep convolutional neural network (CNN) based on deep residual network (ResNet) was proposed to efficiently reconstruct reliable T2 mapping from single-shot overlapping-echo detachment (OLED) planar imaging. METHODS: The training dataset was obtained from simulations that were carried out on SPROM (Simulation with PRoduct Operator Matrix) software developed by our group. The relationship between the original OLED image containing two echo signals and the corresponding T2 mapping was learned by ResNet training...
April 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Kristin Fraser, Kevin McLaughlin
BACKGROUND: In the simulated clinical environment, there is a perceived benefit to the emotional activation experienced by learners; however, potential harm of excessive and/or negative emotions has also been hypothesized. An improved understanding of the emotional experiences of learners during each phase of the simulation session will inform instructional design. METHODS: In this observational study, we asked 174 first-year medical students about their emotional state upon arrival to the simulation lab (t1)...
April 24, 2018: Medical Teacher
Dawid Aleksandrowicz, Tomasz Gaszyński
OBJECTIVES: The aim of this study was to compare the intubating laryngeal mask (iLM) airway and the new intubating laryngeal tube (iLTS-D) in use by residents with minimal previous intubation experience during simulated conditions of reduced cervical spine mobility. MATERIAL AND METHODS: Thirty first-year residents in anesthesiology participated in the study (18 women). All participants had minimal intubation experience (fewer than 10 previously performed intubations) and were novices in the specialty...
June 2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
Kelsey E Larson, Stephen R Grobmyer, Stephanie A Valente
The data on oncologic outcomes in young women with breast cancer (BC) are dated as it relates to recurrences and mortality. Our goal was to assess these outcomes in a modern series of young women with BC. A retrospective chart review identified women ≤40 years old with stage I-III BC diagnosed from 2006 to 2013 at our institution. Demographics, tumor biology, type of operation, recurrence, and survival were analyzed. Overall, 322 women were identified. Most had ER+(70%) infiltrating ductal tumors (88%) with low stage (42% T1; 41% T2; 56% N0)...
April 23, 2018: Breast Journal
Matthew Piazza, Sun H Peck, Sarah E Gullbrand, Justin R Bendigo, Toren Arginteanu, Yejia Zhang, Harvey E Smith, Neil R Malhotra, Lachlan J Smith
Low back pain due to disc degeneration is a major cause of morbidity and health care expenditures worldwide. While stem cell-based therapies hold promise for disc regeneration, there is an urgent need to develop improved in vivo animal models to further develop and validate these potential treatments. The objectives of this study were to characterize a percutaneous needle injury model of intervertebral disc degeneration in the mouse caudal spine, and compare two non-invasive quantitative imaging techniques, microcomputed tomography and magnetic resonance imaging (MRI), as effective measures of disc degeneration in this model...
April 24, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Mohamed Mohamed Elawdy, Yasser Osman, Diaa-Eldin Taha, Samer El-Halwagy, Mohsen El-Mekresh
PURPOSE: There is a lack of reporting of the bladder cuff pathology in the literature and ongoing debate regarding the role of bladder cuff excision (BCE) in the prognosis in patients with upper tract urothelial carcinoma (UTUC). We aimed to know the risk factors, the survival, and the clinical course of such pathology. MATERIALS AND METHODS: The study was retrospective, from 1983-2013 on 305 patients who had diagnosed with UTUC. Patients were managed by radical open/ laparoscopic nephroureterectomy with bladder cuff excision...
April 24, 2018: Urology Journal
Dengxia Yi, Lin Ma, Min Lin, Cong Li
The glyphosate-resistant gene, GR79Ms, was successfully introduced into the genome of alfalfa. The transgenic events may serve as novel germplasm resources in alfalfa breeding. Weed competition can reduce the alfalfa yield, generating new alfalfa germplasm with herbicide resistance is essential. To obtain transgenic alfalfa lines with glyphosate resistance, a new synthetic glyphosate-resistant gene GR79Ms encoding 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) was introduced into alfalfa germplasm by Agrobacterium tumefaciens-mediated transformation...
April 23, 2018: Planta
Lalit R Bansal
An 11-month-old male presented with acute gastroenteritis, seizures, and altered mental status. Laboratory workup revealed serum sodium of 177 mmol/L. Magnetic resonance imaging of the brain showed reduced diffusion in the supratentorial white matter, T2 hyperintensities in the left central pons and midbrain, subacute stroke in the right occipital lobe, and bilateral cerebellar hemorrhagic infarcts. The child was presumed to have hypernatremia-induced central pontine and extrapontine myelinolysis. He received 5 days of high-dose methylprednisolone for persistent encephalopathy and spastic quadriparesis with rapid recovery of his cognitive function and neurological examination...
2018: Child Neurology Open
Alexander Rae-Grant, Gregory S Day, Ruth Ann Marrie, Alejandro Rabinstein, Bruce A C Cree, Gary S Gronseth, Michael Haboubi, June Halper, Jonathan P Hosey, David E Jones, Robert Lisak, Daniel Pelletier, Sonja Potrebic, Cynthia Sitcov, Rick Sommers, Julie Stachowiak, Thomas S D Getchius, Shannon A Merillat, Tamara Pringsheim
OBJECTIVE: To review evidence on starting, switching, and stopping disease-modifying therapies (DMTs) for multiple sclerosis (MS) in clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and progressive MS forms. METHODS: Relevant, peer-reviewed research articles, systematic reviews, and abstracts were identified (MEDLINE, CENTRAL, EMBASE searched from inception to November 2016). Studies were rated using the therapeutic classification scheme. Prior published Cochrane reviews were also used...
April 24, 2018: Neurology
Marcin Czarniecki, Iztok Caglic, James T Grist, Andrew B Gill, Kamil Lorenc, Rhys A Slough, Andrew N Priest, Tristan Barrett
OBJECTIVE: To compare image quality, artefact, and distortion in standard echo-planar imaging (EPI) with periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) for prostate magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) in patients with previous total hip replacement (THR). METHODS: 21 male subjects with a clinical suspicion for, or known prostate cancer and previous THR were scanned at 1.5 T using a phased-array body coil...
May 2018: European Journal of Radiology
Subhendra N Sarkar, David B Hackney, Robert L Greenman, Behroze A Vachha, Emelia A Johnson, Sue Nagle, Gul Moonis
OBJECTIVE: FSE sequences play key roles in neck MRI despite the susceptibility issues in neck region. Iterative decomposition of asymmetric echoes (IDEAL, GE) is a promising method that separates fat and water images resulting in high SNR and improved fat suppression. We tested how neck tissue contrasts, image artifacts and fat separation as opposed to fat suppression in terms of image quality compare between routine and IDEAL FSE. METHODS: IDEAL based and routine T1 and T2 -weighted FSE sequences were applied for neck MRI at 1...
May 2018: European Journal of Radiology
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