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https://www.readbyqxmd.com/read/29909583/clinical-and-radiographical-ten-years-long-term-outcome-of-microfracture-vs-autologous-chondrocyte-implantation-a-matched-pair-analysis
#1
Robert Ossendorff, Kilian Franke, Benjamin Erdle, Markus Uhl, Norbert P Südkamp, Gian M Salzmann
PURPOSE: To compare the clinical and radiographical long-term outcome of microfracture (MFX) and first-generation periosteum-covered autologous chondrocyte implantation (ACI-P). METHODS: All subjects (n = 86) who had been treated with knee joint ACI-P or microfracture (n = 76) with a post-operative follow-up of at least ten years were selected. Clinical pre- and post-operative outcomes were analyzed by numeric analog scale (NAS) for pain, Lysholm, Tegner, IKDC, and KOOS score...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909324/assessment-of-sustainable-deficit-irrigation-in-a-moroccan-apple-orchard-as-a-climate-change-adaptation-strategy
#2
Nabil El Jaouhari, Aziz Abouabdillah, Rachid Bouabid, Mohamed Bourioug, Lotfi Aleya, Mohamed Chaoui
This study was conducted over three consecutive years, 2015, 2016 and 2017, in the Imouzzer Kander region located in northwestern Morocco. The main objective is to evaluate apple tree responses to two sustainable deficit irrigation strategies with 75% (T2) and 50% (T3) of calculated crop evapotranspiration (ETc), compared to a control irrigated with 100% ETc (T1). During the three experiment years, estimated reference evapotranspiration (ET0 ) was 630, 684 and 728 mm, respectively, in 2015, 2016 and 2017...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29909243/uncommon-g9p-4-group-a-rotavirus-strains-causing-dehydrating-diarrhea-in-young-children-in-italy
#3
Giovanni Ianiro, Claudia Recanatini, Marcello M D'Errico, Marina Monini
Group A rotaviruses (RVA) are one of the major cause of acute gastroenteritis (AGE) in young children, being responsible for up to 250.000 deaths worldwide, mostly in developing countries. The two outer capsid proteins VP7 (glycoprotein, G-genotype) and VP4 (protease-sensitive protein, P-genotype) are the basis for the binary RVA nomenclature. Although at least 36 G-types and 51 P-types of rotavirus are presently known, most RVA infections in humans, worldwide as well as in Italy, are related to six major G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]...
June 14, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29909210/synchronous-diagnosis-of-intradiploic-epidermoid-cyst-and-anatomically-close-associated-chronic-epidural-hematoma
#4
Jian Zheng, Hong Zhang, Chun Wang
BACKGROUND: Intradiploic epidermoid cyst (IEC) concurrent with chronic epidural hematoma (CEDH) has never been reported in the literature. We report a unique case of IEC concurrent with anatomically close associated CEDH. CASE DESCRIPTION: A 54-year-old man presented with one week history of headache, confusion and drowsiness. Computed tomography (CT) exposed large extraaxial mixed density lesions with bone destruction and substantial mass effect in the left fronto-temporal region...
June 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29908955/novel-epitopes-identified-from-mycobacterium-tuberculosis-antigen-rv2629induces-cytotoxic-t-lymphocyte-response
#5
Bai Xuejuan, Wang Dongfang, Yinping Liu, Xiao Li, Yan Liang, Yourong Yang, Junxian Zhang, Minggui Lin, Wu Xueqiong
There is an urgent need for a more effective vaccine against tuberculosis (TB). Cytotoxic T lymphocytes (CTLs) play a critical role in combating Mycobacterium tuberculosis (M.tb). The identification of novel CTL epitopes is essential for the design of peptide-based vaccines. In this study, we predicted CTL epitope peptides of M.tb antigen Rv2629 restricted by HLA-A2, using bioinformatics methods. The affinity and stability of binding of these peptides with HLA-A2 molecules were detected by flow cytometry. Their ability to induce CTLs generation was determined in peripheral blood mononuclear cells (PBMCs) from healthy uninfected subjects, Latent tuberculosis infection (LTBI) subjects, and TB patients ex vivo...
June 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29908785/radio-pathomic-maps-of-epithelium-and-lumen-density-predict-the-location-of-high-grade-prostate-cancer
#6
Sean D McGarry, Sarah L Hurrell, Kenneth A Iczkowski, William Hall, Amy L Kaczmarowski, Anjishnu Banerjee, Tucker Keuter, Kenneth Jacobsohn, John D Bukowy, Marja T Nevalainen, Mark D Hohenwalter, William A See, Peter S LaViolette
PURPOSE: This study aims to combine multiparametric magnetic resonance imaging (MRI) and digitized pathology with machine learning to generate predictive maps of histologic features for prostate cancer localization. METHODS AND MATERIALS: Thirty-nine patients underwent MRI prior to prostatectomy. After surgery, tissue was sliced according to MRI orientation using patient-specific 3-dimensionally printed slicing jigs. Whole-mount sections were annotated by our pathologist and digitally contoured to differentiate the lumen and epithelium...
April 24, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29908606/effect-of-ultrasound-transducer-design-on-the-acoustically-assisted-supercritical-fluid-extraction-of-antioxidants-from-oregano
#7
Liliana Santos-Zea, Marilena Antunes-Ricardo, Janet A Gutierrez-Uribe, Jose V García-Pérez, Jose Benedito
Power ultrasound is applied in food technology to intensify extraction processes, due to the phenomena ultrasonic energy induces in the medium, enhancing mass transfer. The purpose of this work was the acoustic characterization of four transducers of different geometries and the evaluation of their performance in the ultrasonically assisted supercritical fluid extraction of antioxidants from oregano. The transducers differed in the amount of energy transmitted into the medium. Designs varied from the base model (T1), a larger cylindrical headmass (T2), a stepped circular section sonotrode (T3) and a multiplate configuration (T4)...
October 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29908311/longitudinal-study-of-neonatal-brain-tissue-volumes-in-preterm-infants-and-their-ability-to-predict-neurodevelopmental-outcome
#8
REVIEW
L Gui, S Loukas, F Lazeyras, P S Hüppi, D E Meskaldji, C Borradori Tolsa
Premature birth has been associated with poor neurodevelopmental outcomes. However, the relation between such outcomes and brain growth in the neonatal period has not yet been fully elucidated. This study investigates longitudinal brain development between birth and term-equivalent age (TEA) by quantitative imaging in a cohort of premature infants born between 26 and 36 weeks gestational age (GA), to provide insight into the relation of brain growth with later neurodevelopmental outcomes. Longitudinal T2-weighted magnetic resonance images (MRI) of 84 prematurely born infants acquired shortly after birth and TEA were automatically segmented into cortical gray matter (CGM), unmyelinated white matter (UWM), subcortical gray matter (SGM), cerebellum (CB) and cerebrospinal fluid (CSF)...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29908082/the-role-of-sigma-1-receptor-in-sex-specific-heat-shock-response-in-an-experimental-rat-model-of-renal-ischemia-reperfusion-injury
#9
Adam Hosszu, Zsuzsanna Antal, Apor Veres-Szekely, Lilla Lenart, Dora Bianka Balogh, Edgar Szkibinszkij, Lilla Illesy, Judit Hodrea, Nora F Banki, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
We previously showed that female rats are more protected against renal ischemia/reperfusion (I/R) injury than males, which is partly attributed to their more pronounced heat shock response. We recently described that Sigma-1 receptor (S1R) activation improves postischemic survival and renal function. 17β-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Proximal tubular cells were treated with 17β-estradiol, which caused direct S1R activation and subsequent induction of heat shock response...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29908031/the-efficacy-of-curcumin-in-managing-acute-inflammation-pain-on-the-post-surgical-removal-of-impacted-third-molars-patients-a-randomized-controlled-trial
#10
Tantry Maulina, Hedy Diana, Arief Cahyanto, Amaliya
BACKGROUND: Curcumin is a turmeric contained active ingredient that has been proven to be effective in treating pain and inflammation due to its analgesic as well as anti-inflammation potential. Odontectomy, on the other hand, has been well known for its post-procedure acute inflammation pain. OBJECTIVE: The aim of the current study was to evaluate the efficacy of curcuminoid in treating acute inflammation post-operative pain in the post-surgical removal of impacted third molars patients...
June 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29907829/multiparametric-magnetic-resonance-imaging-for-quantitation-of-liver-disease-a-two-centre-cross-sectional-observational-study
#11
Natasha McDonald, Peter J Eddowes, James Hodson, Scott I K Semple, Nigel P Davies, Catherine J Kelly, Stella Kin, Miranda Phillips, Amy H Herlihy, Timothy J Kendall, Rachel M Brown, Desley A H Neil, Stefan G Hübscher, Gideon M Hirschfield, Jonathan A Fallowfield
LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907386/a-local-excitation-magnetic-resonance-imaging-method-for-intracranial-unruptured-aneurysm-at-the-distal-internal-carotid-artery
#12
Megumu Suzuki, Takeshi Satow, Taro Komuro, Akira Kobayashi, Susumu Miyamoto
It is often difficult to diagnose an intracranial aneurysm at the distal internal carotid artery by conventional magnetic resonance imaging. PURPOSE: We assessed the effectiveness of the local excitation technique, a new application for magnetic resonance imaging, to clarify the geometric structure of aneurysm and adjacent branches at the distal internal carotid artery. STUDY DESIGN: Two independent evaluators diagnosed 10 cases of suspected aneurysms at the distal internal carotid artery by T2-weighted magnetic resonance imaging with application of local excitation, adding it to conventional time-of-flight-magnetic resonance angiography...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907314/relationship-between-cardiac-mr-compression-classification-and-ct-chest-wall-indexes-in-patients-with-pectus-excavatum
#13
Alejandro Deviggiano, Patricia Carrascosa, Javier Vallejos, Gaston Bellia-Munzon, Natalia Vina, Gaston A Rodríguez-Granillo, Marcelo Martinez-Ferro
BACKGROUND/PURPOSE: In pectus excavatum (PE) patients owing to the location of the heart in the chest cavity, the most affected site of compression by the depressed chest wall is the right heart, and surgical repair has shown to provide a significant relief in the RH cavities compression. Our aim was to explore the relationship between the site of right cardiac compression, chest wall indexes (CT-CWI) and the sternal torsion angle (STA) based on cardiac magnetic resonance (CMR) and computed tomography (CT) among PE patients...
May 23, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29906681/reliability-and-validity-of-the-self-report-version-of-the-apathy-evaluation-scale-in-first-episode-psychosis-concordance-with-the-clinical-version-at-baseline-and-12-months-follow-up
#14
Ann Faerden, Siv Hege Lyngstad, Carmen Simonsen, Petter Andreas Ringen, Oleg Papsuev, Ingrid Dieset, Ole A Andreassen, Ingrid Agartz, Stephen R Marder, Ingrid Melle
Negative symptoms have traditionally been assessed based on clinicians' observations. The subjective experience of negative symptoms in people with psychosis may bring new insight. The Apathy Evaluation Scale (AES) is commonly used to study apathy in psychosis and has corresponding self-rated (AES-S) and clinician-rated (AES-C) versions. The aim of the present study was to determine the validity and reliability of the AES-S by investigating its concordance with the AES-C. Eighty-four first-episode (FEP) patients completed the shortened 12-item AES-S and AES-C at baseline (T1) and 12 months (T2)...
May 31, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29906473/cytotoxic-effects-induced-by-patulin-deoxynivalenol-and-toxin-t2-individually-and-in-combination-in-hepatic-cells-hepg2
#15
Celia Fernández-Blanco, Luigi Elmo, Thomas Waldner, Maria-Jose Ruiz
Patulin (PAT), deoxynivalenol (DON) and toxin T-2 (T-2) are mycotoxins distributed worldwide in food and feed. Cytotoxicity of the three mycotoxins individually or in combination in human hepatocellular carcinoma (HepG2) cells was evaluated by MTT assay over 24, 48 and 72 h of exposure. The concentration ranges used were 0.625-15 μM for DON, 1.25-50 nM for T-2 and 0.45-7.5 μM for PAT. The IC50 values obtained ranged from 9.30 to 2.53 μM, from 33.69 to 44.37 nM and from 2.66 to 1.17 μM for DON, T-2 and PAT, respectively...
June 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29906300/new-treatment-criteria-for-preterm-hyperbilirubinemic-infants-in-japan
#16
Ichiro Morioka
In 1992, Kobe University proposed treatment criteria for hyperbilirubinemic newborns using total serum bilirubin and serum unbound bilirubin reference values. In the last decade, chronic bilirubin encephalopathy has found to develop in preterm infants in Japan because it can now be clinically diagnosed based on an abnormal signal of the globus pallidus in T2-weighted magnetic resonance imaging and abnormal findings of the auditory brainstem response with or without apparent hearing loss, along with physical findings of kinetic disorders with athetosis...
June 15, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29905844/robotic-assisted-mri-guided-interventional-interstitial-mr-guided-focused-ultrasound-ablation-in-a-swine-model
#17
Jacquelyn MacDonell, Niravkumar Patel, Gregory Fischer, E Clif Burdette, Jiang Qian, Vaibhav Chumbalkar, Goutam Ghoshal, Tamas Heffter, Emery Williams, Matthew Gounis, Robert King, Juliette Thibodeau, Gene Bogdanov, Olivia W Brooks, Erin Langan, Roy Hwang, Julie G Pilitsis
BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS). OBJECTIVE: To describe our experience with interstitial focused ultrasound (iFUS) ablations in swine, using MR-guided robotically assisted (MRgRA) delivery...
June 14, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29905601/huge-bursitis-and-bursal-synovial-osteochondromatosis-associated-with-scapular-osteochondroma-mimicking-a-giant-calcific-mass-of-the-chest-wall-a-case-report
#18
Kutsi Tuncer, Emine Izgi, Bahar Cankaya, Hayri Ogul, Mecit Kantarci
Osteochondroma is the most common benign bone tumor but it rarely arises from the scapula. Scapulothoracic bursitis is quite rare and osteochondroma is one of the unusual causes of this condition. Synovial chondromatosis may occur extremely uncommonly in this bursa. We reported an unusual case of scapulothoracic bursitis with synovial chondromatosis which is caused by osteochondroma. To the best of our knowledge, there is no defined chondromatosis in the scapulothoracic bursa secondary to scapular osteochondroma in the literature...
June 13, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29905159/atypical-postictal-transient-subcortical-t2-hypointensity-in-a-newly-diagnosed-diabetic-patient-with-seizures
#19
Matteo Paoletti, Ana Bacila, Anna Pichiecchio, Lisa Maria Farina, Elisa Rognone, Riccardo Cremascoli, Simona Fanucchi, Raffaele Manni, Stefano Bastianello
Common postictal MRI findings include transient cortical T2 hyperintensity, restricted diffusion, and gyral and/or adjacent leptomeningeal contrast enhancement. In certain uncommon pathological conditions, other signal abnormalities can be present, suggesting a different underlying pathogenic mechanism. We report the case of a 66-year-old man, recently diagnosed with diabetes mellitus type 2, presenting with new-onset visual and auditory hallucinations, "absence" seizures, and repeated peaks of hyperglycaemia without hyperketonaemia or increased serum osmolarity...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29904916/postural-control-during-reaching-while-sitting-and-general-motor-behaviour-when-learning-to-walk
#20
Anke G Boxum, Sacha La Bastide-Van Gemert, Linze-Jaap Dijkstra, Anna Furda, Heleen A Reinders-Messelink, Mijna Hadders-Algra
AIM: To study changes in muscular postural strategies and general motor behaviour during the transition to independent walking. Postural control was assessed at its two functional levels: (1) direction specificity, in which dorsal muscles are primarily activated when reaching forward; and (2) fine-tuning of direction specificity. METHOD: In an explorative longitudinal study, surface electromyograms of the arm, trunk, and neck muscles of 28 typically developing infants were recorded during reaching while sitting...
June 14, 2018: Developmental Medicine and Child Neurology
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