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https://www.readbyqxmd.com/read/29791800/tip-enhanced-raman-scattering-from-nano-patterned-graphene-and-graphene-oxide
#1
Ashish Bhattarai, Andrey Krayev, Alexey Temiryazev, Dmitry Evplov, Kevin Thomas Crampton, Wayne P Hess, Patrick Z El Khoury
Tip-enhanced Raman spectroscopy (TERS) is particularly sensitive to analytes residing at plasmonic tip-sample nanojunctions, where the incident and scattered optical fields may be localized and optimally enhanced. However, the enhanced local electric fields in this so-called gap-mode TERS configuration are nominally orthogonal to the sample plane. As such, any given Raman active vibrational Eigenstate needs to have projections (of its polarizability derivative tensor elements) along the sample normal to be detectable via TERS...
May 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29775092/a-prospective-multi-centre-us-clinical-trial-to-determine-accuracy-of-febridx-point-of-care-testing-for-acute-upper-respiratory-infections-with-and-without-a-confirmed-fever
#2
Nathan I Shapiro, Wesley H Self, Jeffrey Rosen, Stephan C Sharp, Michael R Filbin, Peter C Hou, Amisha D Parekh, Michael C Kurz, Robert Sambursky
BACKGROUND: FebriDx is a 10-minute disposable point-of-care test designed to identify clinically significant systemic host immune responses and aid in the differentiation of bacterial and viral respiratory infection by simultaneously detecting C-reactive protein (CRP) and myxovirus resistance protein A (MxA) from a fingerstick blood sample. FebriDx diagnostic accuracy was evaluated in the emergency room and urgent care setting. METHODS: A prospective, multicentre, observational cohort study of acute upper respiratory tract infections (URIs), with and without a confirmed fever at the time of enrolment, was performed to evaluate the diagnostic accuracy of FebriDx to identify clinically significant bacterial infection with host response and acute pathogenic viral infection...
May 18, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29769128/the-impact-of-the-scale-up-of-malaria-rapid-diagnostic-tests-on-the-routine-clinical-diagnosis-procedures-for-febrile-illness-a-series-of-repeated-cross-sectional-studies-in-papua-new-guinea
#3
Justin Pulford, Serah Kurumop, Ivo Mueller, Peter M Siba, Manuel W Hetzel
BACKGROUND: This paper examines the impact of the scale-up of malaria rapid diagnostic tests (RDT) on routine clinical diagnosis procedures for febrile illness in primary healthcare settings in Papua New Guinea. METHODS: Repeat, cross-sectional surveys in randomly selected primary healthcare services were conducted. Surveys included passive observation of consecutive febrile case management cases and were completed immediately prior to RDT scale-up (2011) and at 12- (2012) and 60-months (2016) post scale-up...
May 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29746573/self-diagnosis-of-seasonal-influenza-in-a-rural-primary-care-setting-in-japan-a-cross-sectional-observational-study
#4
Hiroki Maita, Tadashi Kobayashi, Hiroshi Osawa, Hiroyuki Kato
OBJECTIVE: To elucidate the accuracy and optimal cut-off point of self-diagnosis and clinical symptoms of seasonal influenza compared with rapid influenza diagnostic tests as the reference standard, we conducted a cross sectional observational study at a rural clinic in Japan. METHODS: Data during three influenza seasons (December 2013 to April 2016) were retrospectively collected from the medical records and pre-examination sheets of 111 patients aged >11 years (mean age 48...
2018: PloS One
https://www.readbyqxmd.com/read/29745910/misdiagnosed-patient-with-latent-autoimmune-diabetes-in-adults-case-report
#5
H Petreski
Latent Autoimmune Diabetes in Adults (LADA) is often misdiagnosed because it lacks both awareness and standardized diagnostic criteria. A 30-year-old patient with high blood glucose, HbA1c level 10.1% and positive GAD antibodies was diagnosed with type 1 diabetes but LADA was not ruled out. Patient refused to receive insulin therapy. He chose to follow the dietary restrictions and therapy with sulfonylurea, initiated by another physician. Following 7 months the patient's HbA1c values decreased, but never achieved the goal...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29741900/time-resolved-gas-phase-kinetic-study-of-sid-2-c-2-h-4
#6
Najem A Al-Rubaiey, Robin Walsh
Time-resolved investigation of deuterium-substituted silylene (SiD2) generated by laser flash photolysis of deuterium-substituted phenylsilane (PhSiD3), was carried out to obtain rate constants for its bimolecular reaction with ethylene (C2H4). The reaction was studied in the gas phase, over the pressure range of 1-100 Torr (in SF6 bath gas) at 295K. The rate constants for SiD2+C2H4 were found to be independent of pressure, and close in magnitude to the rate constants for the reaction of SiH2+C2H4 at the high pressure limit...
May 9, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29728285/comparison-of-bedside-screening-methods-for-frailty-assessment-in-older-adult-trauma-patients-in-the-emergency-department
#7
Sachita P Shah, Kevin Penn, Stephen J Kaplan, Michael Vrablik, Karl Jablonowski, Tam N Pham, May J Reed
BACKGROUND: Frailty is linked to poor outcomes in older patients. We prospectively compared the utility of the picture-based Clinical Frailty Scale (CFS9), clinical assessments, and ultrasound muscle measurements against the reference FRAIL scale in older adult trauma patients in the emergency department (ED). METHODS: We recruited a convenience sample of adults 65 yrs. or older with blunt trauma and injury severity scores <9. We queried subjects (or surrogates) on the FRAIL scale, and compared this to: physician-based and subject/surrogate-based CFS9; mid-upper arm circumference (MUAC) and grip strength; and ultrasound (US) measures of muscle thickness (limbs and abdominal wall)...
April 14, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29717641/eastern-equine-encephalitis-in-puppies-in-michigan-and-new-york-states
#8
Caroline Andrews, Jodie Gerdin, Jon Patterson, Elizabeth L Buckles, Scott D Fitzgerald
Eastern equine encephalitis virus (EEEV) is classified as a select agent and is capable of causing mortality in humans and a number of veterinary species. Herein, we describe 3 cases of EEE in puppies in Michigan and New York. Two puppies were euthanized following an acute history of seizures and obtundation. A littermate of one of these puppies died 2 wk earlier following a history of anorexia and fever. All 3 puppies lacked significant gross anatomic lesions at autopsy and tested negative for rabies virus...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29688491/a-case-of-delayed-diagnosis-of-east-african-trypanosomiasis-in-a-dutch-traveller
#9
C A Wijsman, J L J Hanssen, H Scheper, L G Visser, L van Lieshout
We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya. The diagnosis was delayed due to the lack of suspicion and secondly because of postponed analysis of blood microscopy after negative rapid malaria antigen testing. Second stage trypanosomiasis was ruled out with liquor analysis. She was treated first with pentamidine and shortly thereafter with suramin, after which she recovered. We emphasize the use of thin/thick smear diagnostics in travellers returning from endemic countries...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29686988/validation-and-search-of-the-ideal-cut-off-of-the-sysmex-uf-1000i-%C3%A2-flow-cytometer-for-the-diagnosis-of-urinary-tract-infection-in-a-tertiary-hospital-in-spain
#10
María I Millán-Lou, Juan M García-Lechuz, María A Ruiz-Andrés, Concepción López, María J Aldea, María J Revillo, Antonio Rezusta
Urinary tract infections (UTI) are one of the most prevalent infections. A rapid and reliable screening method is useful to screen out negative samples. The objective of this study was to validate the Sysmex flow cytometer UF-1000i by evaluating its accuracy, linearity and carry-over; and define an optimal cut-off value to be used in routine practice in our hospital. For the validation of the UF-1000i cytometer, precision, linearity and carry-over were studied in samples with different counts of bacteria, leukocytes and erythrocytes...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29685630/symptomatic-medulla-compression-by-vertebral-artery
#11
Leszek Lombarski, Przemysław Kunert, Marcin Skawiński, Marek Prokopienko, Zbigniew Lewandowski, Andrzej Marchel
OBJECTIVE: Vertebral artery medulla compression syndrome (VAMCS) is a very rare condition manifesting as different neurological focal deficits. The case of a 36-year-old male with symptomatic brainstem compression by vertebral artery (VA) treated by means of microvascular decompression (MVD) and a review of the literature is presented. CASE REPORT: On admission, a 36-year-old patient presented with hypoalgesia, hypothermesthesia and hemiparesis on the left side...
March 17, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29675245/coupling-of-sterically-demanding-peptides-by-%C3%AE-thiolactone-mediated-native-chemical-ligation
#12
Huan Chen, Yunxian Xiao, Ning Yuan, Jiaping Weng, Pengcheng Gao, Leonard Breindel, Alexander Shekhtman, Qiang Zhang
The ligation of sterically demanding peptidyl sites such as those involving Val-Val and Val-Pro linkages has proven to be extremely challenging with conventional NCL methods that rely on exogenous thiol additives. Herein, we report an efficient β-thiolactone-mediated additive-free NCL protocol that enables the establishment of these connections in good yield. The rapid NCL was followed by in situ desulfurization. Reaction rates between β-thiolactones and conventional thioesters towards NCL were also investigated, and direct aminolysis was ruled out as a possible pathway...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29668333/blood-biomarkers-in-ischemic-stroke-potential-role-and-challenges-in-clinical-practice-and-research
#13
Konstantinos Makris, Alexander Haliassos, Maria Chondrogianni, Georgios Tsivgoulis
Fast and accurate diagnosis of stroke is crucial for the immediate application of the right therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke cannot be identified based only on clinical assessment. CT or MRI imaging is required to rule out hemorrhagic stroke since thrombolytic therapy can lead to increased intracranial bleeding and further aggravation of hemorrhagic stroke. In addition, clinical situations that imitate the signs and symptoms of stroke may also impede the rapid diagnosis and treatment of stroke victims...
April 18, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29666711/creutzfeldt-jakob-disease-presenting-as-expressive-aphasia-and-nonconvulsive-status-epilepticus
#14
Hafiz B Mahboob, Kazi H Kaokaf, Jeremy M Gonda
Creutzfeldt-Jakob disease (CJD), the most common form of human prion diseases, is a fatal condition with a mortality rate reaching 85% within one year of clinical presentation. CJD is characterized by rapidly progressive neurological deterioration in combination with typical electroencephalography (EEG) and magnetic resonance imaging (MRI) findings and positive cerebrospinal spinal fluid (CSF) analysis for 14-3-3 proteins. Unfortunately, CJD can have atypical clinical and radiological presentation in approximately 10% of cases, thus making the diagnosis often challenging...
2018: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29643212/stable-social-relationships-between-unrelated-females-increase-individual-fitness-in-a-cooperative-bird
#15
Christina Riehl, Meghan J Strong
Social animals often form long-lasting relationships with fellow group members, usually with close kin. In primates, strong social bonds have been associated with increased longevity, offspring survival and reproductive success. However, little is known about the fitness effects of social bonds between non-kin, especially outside of mammals. In this study, we use long-term field research on a cooperatively breeding bird, the greater ani ( Crotophaga major ), to ask whether adult females benefit by remaining in long-term associations with unrelated, co-breeding females...
April 11, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29643118/tfiih-is-highly-dynamic-during-zygotic-genome-activation-in-drosophila-and-its-depletion-causes-catastrophic-mitosis
#16
Grisel Cruz-Becerra, Sarai Valerio-Cabrera, Mandy Juárez, Alyeri Bucio-Mendez, Mario Zurita
In Drosophila zygotic genome activation occurs in pre-blastoderm embryos during rapid mitotic divisions. How the transcription machinery is coordinated to achieve this goal in a very brief time span is still poorly understood. TFIIH is fundamental for transcription initiation by RNA polymerase II (RNAPII). Herein, we show the in vivo dynamics of TFIIH at the onset of transcription in Drosophila embryos. TFIIH shows an oscillatory behaviour between the nucleus and cytoplasm. TFIIH foci are observed from interphase to metaphase, and co-localize with the RNAPII phosphorylated at serine 5 (RNAPIIS5P) at prophase, suggesting that transcription overlaps with the first mitotic phases...
April 11, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29627817/quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-1-individual-participant-data-meta-analysis-and-health-economic-analysis
#17
Sarah J Stock, Lisa M Wotherspoon, Kathleen A Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben W Mol, Richard D Riley, John Norrie, Jane E Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (qfFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts) which quantifies fFN in a vaginal swab. In part 1 of the study, we will develop and internally validate a prognostic model using an individual participant data (IPD) meta-analysis of existing studies containing women with symptoms of preterm labour alongside fFN measurements and pregnancy outcome...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29623380/rate-of-recalibration-to-changing-affordances-for-squeezing-through-doorways-reveals-the-role-of-feedback
#18
John M Franchak, Frank A Somoano
Recalibration of affordance perception in response to changing motor abilities can only occur if observers detect appropriate perceptual information. Recent work suggests that although many affordances can be recalibrated without practicing the specific action to gather outcome feedback-information about whether the attempted action succeeded or failed-calibration of other affordances might depend on outcome feedback (Franchak, Attent Percept Psychophys 79:1816-1829, 2017). However, past work could not rule out the possibility that practicing the action produced perceptual-motor feedback besides outcome feedback that facilitated recalibration...
April 5, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29616352/efast-for-the-diagnosis-of-a-perioperative-complication-during-percutaneous-nephrolithotomy
#19
Achyut Sharma, Prajjwal Bhattarai, Apurb Sharma
A 29-year-old patient with normal preanesthetic evaluation was planned for percutaneous nephrolithotomy (PCNL) for right nephrolithiasis with right pyelolithiasis. Surgery was performed under general anesthesia with endotracheal intubation with muscle relaxation. At the conclusion of surgery, when the patient was turned over to supine position, tense abdomen was noted. Immediately extended focused assessment with sonography in trauma (eFAST) was done in which both right and left quadrants of abdomen including pericardial and suprapubic region, right and left thoracic, and both lung basis were examined...
April 3, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29610381/the-utility-of-the-historical-record-for-assessing-the-transient-climate-response-to-cumulative-emissions
#20
Richard J Millar, Pierre Friedlingstein
The historical observational record offers a way to constrain the relationship between cumulative carbon dioxide emissions and global mean warming. We use a standard detection and attribution technique, along with observational uncertainties to estimate the all-forcing or 'effective' transient climate response to cumulative emissions (TCRE) from the observational record. Accounting for observational uncertainty and uncertainty in historical non-CO2 radiative forcing gives a best-estimate from the historical record of 1...
May 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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