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https://www.readbyqxmd.com/read/29147961/spatiotemporal-competition-and-task-relevance-shape-the-spatial-distribution-of-emotional-interference-during-rapid-visual-processing-evidence-from-gaze-contingent-eye-tracking
#1
Briana L Kennedy, Daniel Pearson, David J Sutton, Tom Beesley, Steven B Most
People's ability to perceive rapidly presented targets can be disrupted both by voluntary encoding of a preceding target and by spontaneous attention to salient distractors. Distinctions between these sources of interference can be found when people search for a target in multiple rapid streams instead of a single stream: voluntary encoding of a preceding target often elicits subsequent perceptual lapses across the visual field, whereas spontaneous attention to emotionally salient distractors appears to elicit a spatially localized lapse, giving rise to a theoretical account suggesting that emotional distractors and subsequent targets compete spatiotemporally during rapid serial visual processing...
November 16, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29135828/improved-diagnostic-performance-of-an-immunofluorescence-based-rapid-antigen-detection-test-for-group-a-streptococci-in-children-with-pharyngitis
#2
Laurence Lacroix, Abdessalam Cherkaoui, Diane Schaller, Sergio Manzano, Annick Galetto-Lacour, Ulrich Pfeifer, René Tabin, Alain Gervaix
BACKGROUND: Accurate diagnosis and appropriate treatment of Group A streptococcal (GAS) pharyngitis are important to prevent complications. Most available rapid antigen detection tests (RADTs) have shown excellent specificity but often lack sensitivity. Our objective was to compare the diagnostic performances of a new fluorescence-based immunoassay and a classic immunochromatographic RADT using standard throat culture or PCR as references. MATERIALS/METHODS: Prospective observational study in 2 pediatric emergency departments in children aged 3 to 15 years old presenting with pharyngitis and a McIsaac score ≥ 2...
November 11, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29135309/screening-for-platelet-function-disorders-with-multiplate-and-platelet-function-analyzer
#3
Floor C J I Moenen, Minka J A Vries, Patricia J Nelemans, Katrien J M van Rooy, Jeannique R R A Vranken, Paul W M Verhezen, Rick J H Wetzels, Hugo Ten Cate, Harry C Schouten, Erik A M Beckers, Yvonne M C Henskens
Light transmission aggregation (LTA) is the gold standard for the diagnosis of platelet function disorders (PFDs), but it is time-consuming and limited to specialized laboratories. Whole-blood impedance aggregometry (Multiplate) and platelet function analyzer (PFA) may be used as rapid screening tools to exclude PFDs. The aim of this study is to assess the diagnostic performance of Multiplate and PFA for PFDs, as detected by LTA.Data from preoperative patients, patients referred to the hematologist for bleeding evaluation, and patients with a diagnosed bleeding disorder were used...
November 14, 2017: Platelets
https://www.readbyqxmd.com/read/29122466/novel-algorithm-to-help-identify-stroke-mimics
#4
Nadeem Israr Khan, Shilpa Chaku, Christina Goehl, Laura Endris, Georgia Mueller-Luckey, Fazeel M Siddiqui
BACKGROUND: Stroke is a major cause of disability in the United States. A portion of patients presenting with stroke-like symptoms in the emergency room who receive tissue plasminogen activator (tPA) do not end up having a true stroke, leading to unnecessary health-care costs. The aim of our study is to identify those patients who have a high likelihood of experiencing a stroke mimic using a novel stroke mimic score and to identify a cutoff point with a high specificity of ruling in stroke mimics...
November 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29112664/placental-alpha-microglobulin-1-compared-with-fetal-fibronectin-to-predict-preterm-delivery-in-symptomatic-women
#5
Deborah A Wing, Sina Haeri, Angela C Silber, Cheryl K Roth, Carl P Weiner, Nelson C Echebiri, Albert Franco, Lanissa M Pappas, John D Yeast, Angelle A Brebnor, J Gerald Quirk, Aisling M Murphy, Louise C Laurent, Nancy T Field, Mary E Norton
OBJECTIVE: To compare the rapid bedside test for placental α microglobulin-1 with the instrumented fetal fibronectin test for prediction of imminent spontaneous preterm delivery among women with symptoms of preterm labor. METHODS: We conducted a prospective observational study on pregnant women with signs or symptoms suggestive of preterm labor between 24 and 35 weeks of gestation with intact membranes and cervical dilatation less than 3 cm. Participants were prospectively enrolled at 15 U...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29101287/0-1-hour-triage-algorithm-for-myocardial-infarction-in-patients-with-renal-dysfunction
#6
Raphael Twerenbold, Patrick Badertscher, Jasper Boeddinghaus, Thomas Nestelberger, Karin Wildi, Christian Puelacher, Zaid Sabti, Maria Rubini Gimenez, Sandra Tschirky, Jeanne du Fay de Lavallaz, Nikola Kozhuharov, Lorraine Sazgary, Deborah Mueller, Tobias Breidthardt, Ivo Strebel, Dayana Flores Widmer, Samyut Shrestha, Òscar Miró, F Javier Martín-Sánchez, Beata Morawiec, Jiri Parenica, Nicolas Geigy, Dagmar I Keller, Katharina Rentsch, Arnold von Eckardstein, Stefan Osswald, Tobias Reichlin, Christian Mueller
Background -The European Society of Cardiology (ESC) recommends a 0/1h-algorithm for rapid rule-out and rule-in of Non-ST-Segment-Elevation Myocardial Infarction (NSTEMI) using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective of renal function. As patients with renal dysfunction (RD) frequently present with increased hs-cTn concentrations even in absence of NSTEMI, concern has been raised regarding the performance of the 0/1h-algorithm in RD. Methods -In a prospective multicenter diagnostic study enrolling unselected patients presenting with suspected NSTEMI to the emergency department, we assessed the diagnostic performance of the ESC 0/1h-algorithm using hs-cTnT and hs-cTnI in patients with RD, defined as an estimated glomerular filtration rate below 60mL/min/1...
November 3, 2017: Circulation
https://www.readbyqxmd.com/read/29097448/using-simulation-to-develop-care-models-for-rapid-response-and-code-teams-at-a-satellite-facility
#7
Amy R L Rule, Julie Snider, Cheryl Marshall, Kathleen Kramer, Gary L Geis, Ken Tegtmeyer, Craig H Gosdin
BACKGROUND: Our institution recently completed an expansion of an acute care inpatient unit within a satellite hospital that does not include an on-site ICU or PICU. Because of expected increases in volume and acuity, new care models for Rapid Response Teams (RRTs) and Code Blue Teams were necessary. OBJECTIVES: Using simulation-based training, our objectives were to define the optimal roles and responsibilities for team members (including ICU physicians via telemedicine), refine the staffing of RRTs and code Teams, and identify latent safety threats (LSTs) before opening the expanded inpatient unit...
November 2, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29077680/complications-from-surgically-assisted-rapid-maxillary-expansion-with-haas-and-hyrax-expanders
#8
Max Domingues Pereira, Alexandre Fukuzo Koga, Gabriela Pereira Ribeiro Prado, Lydia Masako Ferreira
The current study aimed at comparing the number and type of undesired outcomes during and after the maxillary expansion performed with HYRAX and HAAS expanders. A total of 90 patients (41 males and 49 females, 45.6% and 54.4%, respectively) aged 18 to 59 (mean age of 26.1; standard deviation [SD] = 7.4) underwent subtotal Le Fort I osteotomy and pterygomaxillary disjunction following surgically assisted rapid maxillary expansion (SARME) carried out using HAAS (n = 29; 48.3% male and 51.7% female; mean age = 27: SD = 7...
October 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29077601/live-threatening-autoimmune-cardiomyopathy-reproducibly-induced-in-a-patient-by-checkpoint-inhibitor-therapy
#9
Azadeh Tajmir-Riahi, Tanja Bergmann, Michael Schmid, Abbas Agaimy, Gerold Schuler, Lucie Heinzerling
Checkpoint inhibitors induce a plethora of immune-related adverse events (irAEs) including autoimmune colitis, hepatitis, endocrinopathies, and rarer side effects like neuritis. Here, a case of autoimmune cardiomyopathy (grade 3 CTCAE) and myocarditis under combination therapy with nivolumab plus ipilimumab in a 72-year-old melanoma patient is reported. Treatment induced a partial response for 14 months. However, after 10 infusions the patient developed dyspnea, edema of the legs, ascites and a weight gain of 10 kg because of a decompensated heart insufficiency with a reduced ejection fraction from formerly 48%-50% to 15%...
October 26, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29070061/effectiveness-of-real-time-polymerase-chain-reaction-assay-for-the-detection-of-mycobacterium-tuberculosis-in-pathological-samples-a-systematic-review-and-meta-analysis
#10
Emmanuel O Babafemi, Benny P Cherian, Lee Banting, Graham A Mills, Kandala Ngianga
BACKGROUND: Rapid and accurate diagnosis of tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Many established diagnostic methods suffer from low sensitivity or delay of timely results and are inadequate for rapid detection of Mycobacterium tuberculosis (MTB) in pulmonary and extra-pulmonary clinical samples. This study examined whether a real-time polymerase chain reaction (RT-PCR) assay, with a turn-a-round time of 2 h, would prove effective for routine detection of MTB by clinical microbiology laboratories...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29063568/capturing-the-patient-s-perspective-a-review-of-advances-in-natural-language-processing-of-health-related-text
#11
G Gonzalez-Hernandez, A Sarker, K O'Connor, G Savova
Background: Natural Language Processing (NLP) methods are increasingly being utilized to mine knowledge from unstructured health-related texts. Recent advances in noisy text processing techniques are enabling researchers and medical domain experts to go beyond the information encapsulated in published texts (e.g., clinical trials and systematic reviews) and structured questionnaires, and obtain perspectives from other unstructured sources such as Electronic Health Records (EHRs) and social media posts. Objectives: To review the recently published literature discussing the application of NLP techniques for mining health-related information from EHRs and social media posts...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29032871/can-a-negative-high-sensitivity-troponin-result-rapidly-rule-out-acute-myocardial-infarction
#12
EDITORIAL
Nathan M Finnerty, Michael B Weinstock
No abstract text is available yet for this article.
October 9, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29021877/determining-if-positive-predictive-value-using-laboratory-risk-indicator-for-necrotising-fasciitis-is-applicable-in-malaysian-patients-with-necrotising-fasciitis
#13
A Syed, T Alvin, A Fazrina, R Abdul
Introduction: Necrotising fasciitis (NF) is a rapidly progressive infection of the subcutaneous tissue and fascia which spreads rapidly. The scoring system of Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) developed by Wong et al has been proposed as a tool for distinguishing NF and other soft tissue infections (STI) in Singapore. We set out to establish whether the LRINEC score is applicable in our Malaysian setting. Materials and Methods: A cross sectional study of all patients admitted to our hospital diagnosed with NF or To Rule Out NF (TRO NF) between January 1st 2016 to 30th June 2016...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29021638/real-time-pcr-assay-for-the-diagnosis-of-pleural-tuberculosis
#14
Martha Alejandra Casallas-Rivera, Ana María Cárdenas Bernal, Luis Fernando Giraldo-Cadavid, Enrique Prieto Diago, Sandra Paola Santander
INTRODUCTION: The diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak. OBJECTIVE: To establish the operating characteristics of real-time polymerase chain reaction (RT-PCR) hybridization probes for the diagnosis of pleural tuberculosis. METHODS: The validity of the RT-PCR hybridization probes was evaluated compared to a composite reference method by a cross-sectional study at the Hospital Universitario de la Samaritana...
June 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/28993757/painful-and-prolonged-muscle-cramps-following-insulin-injections-in-a-patient-with-type-2-diabetes-mellitus-revisiting-the-1992-duke-case
#15
Rami A Ballout, Asma Arabi
A 56-year-old middle-eastern male with a long-standing history of poorly controlled type 2 diabetes mellitus presented to us complaining of severely painful bilateral upper and lower extremity cramps occurring shortly after his rapid-acting insulin analog injection(s). The cramps had started 6 months ago and have been occurring intermittently in non-predictable episodes since then. He had otherwise never experienced any insulin-related adverse reaction(s) before. His cramps are very painful and debilitating, interfering with his daily activities and placing him in a state of constant fear/anxiety of re-experiencing them...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28988901/detection-of-toxigenic-clostridioides-clostridium-difficile-usefulness-of-two-commercially-available-enzyme-immunoassays-and-a-pcr-assay-on-stool-samples-and-stool-isolates
#16
María C Legaria, Raquel Rollet, Ana Di Martino, Liliana Castello, Claudia Barberis, María A Rossetti, María C Guardati, Liliana Fernández Canigia, Graciela Carloni, Mirta Litterio, Marta Rocchi, Eduardo G Anchart, Fernando M Trejo, Jessica Minnaard, Diana Klajn, Silvia C Predari
The best laboratory diagnostic approach to detect Clostridioides [Clostridium] difficile infection (CDI) is a subject of ongoing debate. With the aim of evaluating four laboratory diagnostic methods, 250 unformed stools from patients with suspected CDI submitted to nine medical center laboratories from November 2010 to December 2011, were studied using: (1) an immunochromatographic rapid assay test that combines the qualitative determination of glutamate dehydrogenase (GDH) plus toxins A and B (QAB), the CDIFF QUIK CHEK COMPLETE assay; (2) an enzyme immunoassay for qualitative determination of toxins A and B, the RIDASCREEN™ C...
October 5, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28988739/a-tale-of-black-eschar-in-a-returning-traveller
#17
Elizabeth Liao, David Carr
BACKGROUND: African tick-bite fever is an increasingly common cause for fever in the returning traveller. It needs to be considered in the febrile returning traveller with a characteristic rash: a black eschar. CASE REPORT: We describe a 51-year-old man returning from South Africa who presented to our emergency department with fever, headache, myalgia, and chills. On careful history and skin examination, a black eschar was found on the patient's left lateral shoulder, pointing toward a diagnosis of African tick-bite fever...
October 5, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28986063/utility-of-the-0-hour-1-hour-high-sensitivity-cardiac-troponin-t-algorithm-in-asian-patients-with-suspected-non-st-elevation-myocardial-infarction
#18
Masayuki Shiozaki, Kenji Inoue, Satoru Suwa, Chien-Chang Lee, Yuichi Chikata, Junko Ishiura, Yuki Kimura, Kentaro Fukuda, Hiroshi Tamura, Yasumasa Fujiwara, Masataka Sumiyoshi, Hiroyuki Daida
BACKGROUND: A rapid rule-out or rule-in protocol based on the 0-hour/1-hour algorithm using high-sensitivity cardiac troponin T is recommended by the European Society of Cardiology. However, Asian data are not available. METHODS: This prospective cohort study included 413 patients with suspected non-ST elevation myocardial infarction in 3 hospitals in Japan and Taiwan from November 2014 to April 2017. Patients were divided into 3groups-rule-out, observe, and rule-in-according to the algorithm...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28984423/the-triple-negative-cd34-hla-dr-cd11b-profile-rapidly-and-specifically-identifies-an-acute-promyelocytic-leukemia
#19
K Rahman, R Gupta, M K Singh, M K Sarkar, A Gupta, S Nityanand
INTRODUCTION: The genetic testing to confirm or rule out an acute promyelocytic leukemia (APL) typically takes a minimum of 24-72 hours. Flow cytometric immunophenotyping (FCI) on the other hand provides rapid and objective information to differentiate APL from non-APL. METHODS: FCI features, with single-tube 8-color combination using CD45, CD34, HAL-DR, CD11b, CD13, CD33, and CD117 and CD64, were compared for the 30 consecutive APL and 30 non-APL acute myeloid leukemia (AML) cases which morphologically mimicked an APL...
October 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28981487/oxygen-consumption-in-platelets-as-an-adjunct-diagnostic-method-for-pediatric-mitochondrial-disease
#20
Emil Westerlund, Sigurður E Marelsson, Johannes K Ehinger, Fredrik Sjövall, Saori Morota, Eleonor Åsander Frostner, Anders Oldfors, Niklas Darin, Johan Lundgren, Magnus J Hansson, Vineta Fellman, Eskil Elmér
BACKGROUND: Diagnosing mitochondrial disease (MD) is a challenge. In addition to genetic analyses, clinical practice is to perform invasive procedures such as muscle biopsy for biochemical and histochemical analyses. Blood cell respirometry is rapid and non-invasive. Our aim was to explore its possible role in diagnosing MD. METHODS: Blood samples were collected from 113 pediatric patients, for whom MD was a differential diagnosis. A respiratory analysis model based on ratios (independent of mitochondrial specific content) was derived from a group of healthy controls and tested on the patients...
October 5, 2017: Pediatric Research
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