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https://www.readbyqxmd.com/read/28105599/t1-mapping-using-saturation-recovery-single-shot-acquisition-at-3-tesla-magnetic-resonance-imaging-in-hypertrophic-cardiomyopathy-comparison-to-late-gadolinium-enhancement
#1
Ryo Ogawa, Tomoyuki Kido, Masashi Nakamura, Teruhito Kido, Akira Kurata, Teruyoshi Uetani, Akiyoshi Ogimoto, Masao Miyagawa, Teruhito Mochizuki
PURPOSE: We evaluated the T1 values of segments and slices and the reproducibility in healthy controls, using saturation recovery single-shot acquisition (SASHA) at 3T magnetic resonance imaging. Moreover, we examined the difference in T1 values between hypertrophic cardiomyopathy (HCM) and healthy controls, and compared those with late gadolinium enhancement (LGE). MATERIALS AND METHODS: Twenty-one HCM patients and 10 healthy controls underwent T1 mapping before and after contrast administration...
January 19, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28105550/stable-isotope-labeling-for-improved-comparative-analysis-of-rna-digests-by-mass-spectrometry
#2
Mellie June Paulines, Patrick A Limbach
Even with the advent of high throughput methods to detect modified ribonucleic acids (RNAs), mass spectrometry remains a reliable method to detect, characterize, and place post-transcriptional modifications within an RNA sequence. Here we have developed a stable isotope labeling comparative analysis of RNA digests (SIL-CARD) approach, which improves upon the original (18)O/(16)O labeling CARD method. Like the original, SIL-CARD allows sequence or modification information from a previously uncharacterized in vivo RNA sample to be obtained by direct comparison with a reference RNA, the sequence of which is known...
January 19, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28105468/simulating-the-effect-of-spectroscopic-mri-as-a-metric-for-radiation-therapy-planning-in-patients-with-glioblastoma
#3
J Scott Cordova, Shravan Kandula, Saumya Gurbani, Jim Zhong, Mital Tejani, Oluwatosin Kayode, Kirtesh Patel, Roshan Prabhu, Eduard Schreibmann, Ian Crocker, Chad A Holder, Hyunsuk Shim, Hui-Kuo Shu
Due to glioblastoma's infiltrative nature, an optimal radiation therapy (RT) plan requires targeting infiltration not identified by anatomical magnetic resonance imaging (MRI). Here, high-resolution, whole-brain spectroscopic MRI (sMRI) is used to describe tumor infiltration alongside anatomical MRI and simulate the degree to which it modifies RT target planning. In 11 patients with glioblastoma, data from preRT sMRI scans were processed to give high-resolution, whole-brain metabolite maps normalized by contralateral white matter...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28105111/effect-of-rocuronium-on-the-bispectral-index-under-anesthesia-and-tracheal-intubation
#4
Hui Yue, Jinyu Han, Ling Liu, Kaiyuan Wang, Jincheng Li
The aim of the present study was to investigate the effect of various doses of rocuronium on bispectral index (BIS) responses to propofol induction and tracheal intubation, as well as the role of the non-depolarization muscle relaxant rocuronium on the depth of sedation. A total of 72 patients (American Society of Anesthesiologists physical status I-II) were anaesthetized with propofol using a target-controlled infusion, and randomly divided into two sedation level groups (n=36). The patients were divided into 2 groups according to the BIS value: A normal sedation group (group 1), with a stable BIS value at 40-60, and a deep sedation group (group 2), with a BIS value <20 or with burst suppression...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100190/translation-of-a-tailored-nutrition-and-resistance-exercise-intervention-for-elderly-people-to-a-real-life-setting-adaptation-process-and-pilot-study
#5
Ellen Ji van Dongen, Joanne N Leerlooijer, Jan M Steijns, Michael Tieland, Lisette Cpgm de Groot, Annemien Haveman-Nies
BACKGROUND: Combining increased dietary protein intake and resistance exercise training for elderly people is a promising strategy to prevent or counteract the loss of muscle mass and decrease the risk of disabilities. Using findings from controlled interventions in a real-life setting requires adaptations to the intervention and working procedures of healthcare professionals (HCPs). The aim of this study is to adapt an efficacious intervention for elderly people to a real-life setting (phase one) and test the feasibility and potential impact of this prototype intervention in practice in a pilot study (phase two)...
January 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28097207/upper-arm-and-cardiac-magnetic-resonance-imaging-in-duchenne-muscular-dystrophy
#6
Lasya Gaur, Alexander Hanna, W Patricia Bandettini, Kenneth H Fischbeck, Andrew E Arai, Ami Mankodi
We analyzed quantitative maps of T1 and T2 relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age-range-matched healthy volunteer boys. The cardiac-optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy...
December 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28096723/myocardial-t1-and-t2-mapping-techniques-and-clinical-applications
#7
REVIEW
Pan Ki Kim, Yoo Jin Hong, Dong Jin Im, Young Joo Suh, Chul Hwan Park, Jin Young Kim, Suyon Chang, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Byoung Wook Choi
Cardiac magnetic resonance (CMR) imaging is widely used in various medical fields related to cardiovascular diseases. Rapid technological innovations in magnetic resonance imaging in recent times have resulted in the development of new techniques for CMR imaging. T1 and T2 image mapping sequences enable the direct quantification of T1, T2, and extracellular volume fraction (ECV) values of the myocardium, leading to the progressive integration of these sequences into routine CMR settings. Currently, T1, T2, and ECV values are being recognized as not only robust biomarkers for diagnosis of cardiomyopathies, but also predictive factors for treatment monitoring and prognosis...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28096584/randomized-controlled-study-comparing-the-hemodynamic-response-to-laryngoscopy-and-endotracheal-intubation-with-mccoy-macintosh-and-c-mac-laryngoscopes-in-adult-patients
#8
Faiza Sulaiman Buhari, Venkatesh Selvaraj
BACKGROUND AND AIMS: Earlier studies have shown that the type of laryngoscope blade influences the degree of hemodynamic response to endotracheal intubation. The aim of the study was to evaluate the hemodynamic response to oral endotracheal intubation with C-MAC laryngoscopy and McCoy laryngoscopy compared to that of Macintosh laryngoscopy in adult patients under general anesthesia. MATERIAL AND METHODS: This is a prospective randomized parallel group study. Ninety American Society of Anesthesiologists I patients were randomly allotted into three groups...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28094863/palatal-morphology-changes-in-post-stroke-patients-measured-by-geometric-morphometrics
#9
Huanca Ghislanzoni Luis, Beatrice Leemann, Panagiotis Christou, Frauke Müller, Martin Schimmel, Stavros Kiliaridis
The present study aimed to describe longitudinal palatal shape changes in post-stroke patients when compared to a sample of healthy subjects through linear measurements and geometric morphometrics. The 3D palatal scanned models of seven stroke patients having a 1-year post-stroke follow up were matched with seven control subject of the same age group (range 50-87 years). Intercanine, intermolar distances, and palatal height were measured. 3D images were also analyzed through geometric morphometrics (GMM) to assess changes in the shape of the palate from T0 to T1 (1 year after the stroke)...
January 17, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28090589/spiral-perfusion-imaging-with-consecutive-echoes-spice%C3%A2-for-the-simultaneous-mapping-of-dsc-and-dce-mri-parameters-in-brain-tumor-patients-theory-and-initial-feasibility
#10
Eric S Paulson, Douglas E Prah, Kathleen M Schmainda
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhibits combined T1, T2, and T2* shortening effects in tissue, and therefore, the results of both DCE- and DSC-MRI can be confounded by these opposing effects...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28088361/purification-and-characterisation-of-dsrna-using-ion-pair-reverse-phase-chromatography-and-mass-spectrometry
#11
Alison O Nwokeoji, An-Wen Kung, Peter M Kilby, David E Portwood, Mark J Dickman
RNA interference has provided valuable insight into a wide range of biological systems and is a powerful tool for the analysis of gene function. The exploitation of this pathway to block the expression of specific gene targets holds considerable promise for the development of novel RNAi-based insect management strategies. In addition, there are a wide number of future potential applications of RNAi to control agricultural insect pests as well as its use for prevention of diseases in beneficial insects. The potential to synthesise large quantities of dsRNA by in-vitro transcription or in bacterial systems for RNA interference applications has generated significant demand for the development and application of high throughput analytical tools for the rapid extraction, purification and analysis of dsRNA...
December 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28081157/simultaneous-quantitative-mri-mapping-of-t1-t2-and-magnetic-susceptibility-with-multi-echo-mp2rage
#12
Riccardo Metere, Tobias Kober, Harald E Möller, Andreas Schäfer
The knowledge of relaxation times is essential for understanding the biophysical mechanisms underlying contrast in magnetic resonance imaging. Quantitative experiments, while offering major advantages in terms of reproducibility, may benefit from simultaneous acquisitions. In this work, we demonstrate the possibility of simultaneously recording relaxation-time and susceptibility maps with a prototype Multi-Echo (ME) Magnetization-Prepared 2 RApid Gradient Echoes (MP2RAGE) sequence. T1 maps can be obtained using the MP2RAGE sequence, which is relatively insensitive to inhomogeneities of the radio-frequency transmit field, [Formula: see text]...
2017: PloS One
https://www.readbyqxmd.com/read/28078857/effects-of-sevoflurane-on-cardiopulmonary-function-in-patients-undergoing-coronary-artery-bypass
#13
J Zhang, S Wang
The objective of the current study was to investigate effects of sevoflurane on cardiopulmonary function in patients undergoing coronary artery bypass grafting (CABG). In this study, 60 cases of patients with coronary heart disease (CHD) were selected and randomly divided into the sevoflurane group (group S) and the control group C (group C) with 30 cases in each group. The two groups received intravenous anesthesia. The patients of group C were only given oxygen mask and physiological saline to keep vein open; while the patients of group S were administered with 1% sevoflurane immediately after the beginning of cardiopulmonary bypass (CPB) until the end of the treatment...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078795/a-continuous-infusion-dynamic-mri-model-at-3-0-tesla-for-the-serial-quantitative-evaluation-of-microvascular-proliferation-in-an-animal-model-of-glioblastoma-multiforme
#14
Hunter R Underhill
PURPOSE: To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme. METHODS: The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, K(trans) ; intravascular plasma fraction, vp ) cannot be individually separated and solves for a single parameter (k(vasc) ) that quantifies the T1 -weighted contrast enhancement from dynamic images acquired during continuous contrast agent (CA) infusion...
January 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28078511/intra-individual-comparison-of-different-gadolinium-based-contrast-agents-in-the-quantitative-evaluation-of-c6-glioma-with-dynamic-contrast-enhanced-magnetic-resonance-imaging
#15
Ying Li, Gang Liu, Xin Lou, Zhiye Chen, Lin Ma
This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28077267/rapid-whole-brain-myelin-water-content-mapping-without-an-external-water-standard-at-1-5t
#16
Thanh D Nguyen, Pascal Spincemaille, Susan A Gauthier, Yi Wang
The objective of this study is to develop rapid whole brain mapping of myelin water content (MWC) at 1.5T. The Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) pulse sequence originally developed for myelin water fraction (MWF) mapping was modified to obtain fast mapping of T1 and receiver coil sensitivity needed for MWC computation. The accuracy of the proposed T1 mapping was evaluated by comparing with the standard IR-FSE method. Numerical simulations were performed to assess the accuracy and reliability of the proposed MWC mapping...
January 7, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28077133/t1-and-t2-mapping-for-evaluation-of-myocardial-involvement-in-patients-with-anca-associated-vasculitides
#17
Simon Greulich, Agnes Mayr, Daniel Kitterer, Joerg Latus, Joerg Henes, Hannah Steubing, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: Myocardial involvement in AAV patients might be silent, presenting with no or nonspecific symptoms, normal ECG, and preserved left-ventricular ejection fraction (LV-EF). Since up to 50% of deaths in these patients may be due to myocardial involvement, a reliable diagnostic tool is warranted. In contrast to LGE-CMR, which has its strengths in detecting focal inflammatory or fibrotic processes, recent mapping techniques are able to detect even subtle, diffuse inflammatory or fibrotic processes...
January 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28074530/slice-profile-and-b1-corrections-in-2d-magnetic-resonance-fingerprinting
#18
Dan Ma, Simone Coppo, Yong Chen, Debra F McGivney, Yun Jiang, Shivani Pahwa, Vikas Gulani, Mark A Griswold
PURPOSE: The goal of this study is to characterize and improve the accuracy of 2D magnetic resonance fingerprinting (MRF) scans in the presence of slice profile (SP) and B1 imperfections, which are two main factors that affect quantitative results in MRF. METHODS: The SP and B1 imperfections are characterized and corrected separately. The SP effect is corrected by simulating the radiofrequency pulse in the dictionary, and the B1 is corrected by acquiring a B1 map using the Bloch-Siegert method before each scan...
January 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28070869/fast-t1-and-t2-mapping-methods-the-zoomed-u-flare-sequence-compared-with-epi-and-snapshot-flash-for-abdominal-imaging-at-11-7-tesla
#19
Géraldine Pastor, María Jiménez-González, Sandra Plaza-García, Marta Beraza, Torsten Reese
OBJECTIVE: A newly adapted zoomed ultrafast low-angle RARE (U-FLARE) sequence is described for abdominal imaging applications at 11.7 Tesla and compared with the standard echo-plannar imaging (EPI) and snapshot fast low angle shot (FLASH) methods. MATERIALS AND METHODS: Ultrafast EPI and snapshot-FLASH protocols were evaluated to determine relaxation times in phantoms and in the mouse kidney in vivo. Owing to their apparent shortcomings, imaging artefacts, signal-to-noise ratio (SNR), and variability in the determination of relaxation times, these methods are compared with the newly implemented zoomed U-FLARE sequence...
January 9, 2017: Magma
https://www.readbyqxmd.com/read/28070844/gd-eob-dtpa-enhanced-mri-t1-mapping-for-assessment-of-liver-function-in-rabbit-fibrosis-model-comparison-of-hepatobiliary-phase-images-obtained-at-10-and-20%C3%A2-min
#20
Zhi-Peng Zhou, Li-Ling Long, Li-Juan Huang, Teng-Fei Yang, Zhong-Kui Huang
OBJECTIVES: To compare hepatobiliary phase (HBP) images obtained at 10 and 20 min after Gd-EOB-DTPA-enhanced MRI for assessment of liver function in rabbit fibrosis model on 3.0 T MR imaging. METHODS: 34 animals were separated into three groups: 5 for a control group, 14 for a mild fibrosis group, and 15 for a severe fibrosis group based on pathological proof. T1 relaxation times (T1rt) were measured on T1 mapping and reduction rates of T1rt (rrT1rt) were calculated...
January 9, 2017: La Radiologia Medica
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