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https://www.readbyqxmd.com/read/28710580/assessment-of-acute-kidney-injury-with-t1-mapping-mri-following-solid-organ-transplantation
#1
Matti Peperhove, Van Dai Vo Chieu, Mi-Sun Jang, Marcel Gutberlet, Dagmar Hartung, Susanne Tewes, Gregor Warnecke, Christiane Fegbeutel, Axel Haverich, Wilfried Gwinner, Frank Lehner, Jan Hinrich Bräsen, Hermann Haller, Frank Wacker, Faikah Gueler, Katja Hueper
OBJECTIVES: To evaluate T1 mapping as a non-invasive, functional MRI biomarker in patients shortly after solid organ transplantation to detect acute postsurgical kidney damage and to correlate T1 times with renal function. METHODS: 101 patients within 2 weeks after solid organ transplantation (49 kidney transplantation, 52 lung transplantation) and 14 healthy volunteers were examined by MRI between July 2012 and April 2015 using the modified Look-Locker inversion recovery (MOLLI) sequence...
July 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28704680/differentiating-parotid-tumors-by-quantitative-signal-intensity-evaluation-on-mr-imaging
#2
Eiji Matsusue, Yoshio Fujihara, Eiken Matsuda, Yusuke Tokuyasu, Shu Nakamoto, Kazuhiko Nakamura, Toshihide Ogawa
BACKGROUND: There have been no reports about quantitative evaluations of enhancing components of parotid tumors on conventional MR imaging. PURPOSE: To evaluate the signal intensity of the enhancing components of tumors, including pleomorphic adenomas (PAs), Warthin tumors (WTs) and malignant tumors (MTs), on various MR sequences and to assess the usefulness of quantitative evaluations for differentiation among the three groups of tumors. MATERIAL AND METHODS: A total of 39 histologically proven tumors, including 15 PAs, 17 WTs and 7 MTs, were enrolled in this study...
July 4, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28699910/quantitative-evaluation-of-gd-eob-dtpa-uptake-in-focal-liver-lesions-by-using-t1-mapping-differences-between-hepatocellular-carcinoma-hepatic-focal-nodular-hyperplasia-and-cavernous-hemangioma
#3
Zhenpeng Peng, Chang Li, Tao Chan, Huasong Cai, Yanji Luo, Zhi Dong, Zi-Ping Li, Shi-Ting Feng
OBJECTIVES: To investigate the difference of T1 relaxation time on Gd-EOB-DTPA-enhanced MRI in hepatocellular carcinoma (HCC), hepatic focal nodular hyperplasia (FNH) and cavernous hemangioma of liver (CHL), and to quantitatively evaluate the uptake of Gd-EOB-DTPA in these three focal liver lesions (FLLs). RESULTS: The T1P of CHL was significantly higher than those of HCC and FNH (P < 0.05). Reduction of T1 relaxation time on hepatobiliary phase could be observed in all three types of lesions...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699215/automated-t2-relaxometry-of-the-hippocampus-for-temporal-lobe-epilepsy
#4
Gavin P Winston, Sjoerd B Vos, Jane L Burdett, M Jorge Cardoso, Sebastien Ourselin, John S Duncan
OBJECTIVE: Hippocampal sclerosis (HS), the most common cause of refractory temporal lobe epilepsy, is associated with hippocampal volume loss and increased T2 signal. These can be identified on quantitative imaging with hippocampal volumetry and T2 relaxometry. Although hippocampal segmentation for volumetry has been automated, T2 relaxometry currently involves subjective and time-consuming manual delineation of regions of interest. In this work, we develop and validate an automated technique for hippocampal T2 relaxometry...
July 12, 2017: Epilepsia
https://www.readbyqxmd.com/read/28698881/assessment-of-haemodynamic-response-to-nonselective-beta-blockers-in-portal-hypertension-by-phase-contrast-magnetic-resonance-angiography
#5
Natasha McDonald, David M L Lilburn, Neil J Lachlan, Gillian Macnaught, Dilip Patel, Arjun N A Jayaswal, Peter C Hayes, Scott I Semple, Jonathan A Fallowfield
A significant unmet need exists for accurate, reproducible, noninvasive diagnostic tools to assess and monitor portal hypertension (PHT). We report the first use of quantitative MRI markers for the haemodynamic assessment of nonselective beta-blockers (NSBB) in PHT. In a randomized parallel feasibility study in 22 adult patients with PHT and a clinical indication for NSBB, we acquired haemodynamic data at baseline and after 4 weeks of NSBB (propranolol or carvedilol) using phase-contrast MR angiography (PC-MRA) in selected intra-abdominal vessels...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28694017/multi-frequency-interpolation-in-spiral-magnetic-resonance-fingerprinting-for-correction-of-off-resonance-blurring
#6
Jason Ostenson, Ryan K Robison, Nicholas R Zwart, E Brian Welch
Magnetic resonance fingerprinting (MRF) pulse sequences often employ spiral trajectories for data readout. Spiral k-space acquisitions are vulnerable to blurring in the spatial domain in the presence of static field off-resonance. This work describes a blurring correction algorithm for use in spiral MRF and demonstrates its effectiveness in phantom and in vivo experiments. Results show that image quality of T1 and T2 parametric maps is improved by application of this correction. This MRF correction has negligible effect on the concordance correlation coefficient and improves coefficient of variation in regions of off-resonance relative to uncorrected measurements...
July 7, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28693687/abnormal-alterations-of-cortical-thickness-in-16-patients-with-type-2-diabetes-mellitus-a-pilot-mri-study-%C3%A2
#7
Chen Zhiye, Zang Xiujuan, Liu Mengqi, Liu Mengyu, Li Jinfeng, Gu Zhaoyan, Ma Lin
Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI).Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28693299/magnetic-resonance-imaging-characteristics-of-ischemic-brain-infarction-according-to-time-passage-in-a-canine-stroke-model
#8
Sooyoung Choi, Daji Noh, Youngwhan Kim, Inseong Jeong, Hojung Choi, Youngwon Lee, Kija Lee
This study describes magnetic resonance imaging findings and changes in lateral ventricular size according to time passage of canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient mapping were obtained at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of 14 beagle dogs...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28691530/depressive-symptoms-in-parkinson-s-disease-are-related-to-decreased-left-hippocampal-volume-correlation-with-the-15-item-shortened-version-of-the-geriatric-depression-scale
#9
Masami Goto, Koji Kamagata, Taku Hatano, Nobutaka Hattori, Osamu Abe, Shigeki Aoki, Masaaki Hori, Tsutomu Gomi
Background The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson's disease (PD) is a controversial issue. Purpose To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods In the present study, 46 participants with PD were scanned with 3 T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28690388/-23-na-mri-and-myometry-to-compare-eplerenone-vs-glucocorticoid-treatment-in-duchenne-dystrophy
#10
Philip A Glemser, Heike Jaeger, Armin M Nagel, Andreas E Ziegler, David Simons, Heinz-Peter Schlemmer, Frank Lehmann-Horn, Karin Jurkat-Rott, Marc-André Weber
In this pilot study we tested whether a low dose application of a mild diuretic substance such as eplerenone is beneficial in early stages of Duchenne muscular dystrophy using (23)Na und (1)H imaging, myometry, and clinical testing versus the glucocorticoid gold standard. Two 7-years old patients with DMD were examined on a 3T MRI system. (1)H MRI and (23)Na density-adapted 3-dimensional radial MRI sequences were performed both before and 1, 3 and 6 months after therapy with eplerenone respectively cortisone...
March 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/28689257/fluid-attenuated-inversion-recovery-vascular-hyperintensities-in-predicting-cerebral-hyperperfusion-after-intracranial-arterial-stenting
#11
Chih-Cheng Wan, David Yen-Ting Chen, Ying-Chi Tseng, Feng-Xian Yan, Kun-Yu Lee, Chen-Hua Chiang, Chi-Jen Chen
PURPOSE: No reliable imaging sign predicting cerebral hyperperfusion after intracranial arterial stenting (IAS) had been described in the literature. This study evaluated the effect of fluid-attenuated inversion recovery vascular hyperintensities (FVHs), also called hyperintense vessel sign on T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) MR images, in predicting significant increase in cerebral blood flow (CBF) defined by arterial spin labeling (ASL) after IAS. METHODS: We reviewed ASL CBF images and T2-FLAIR MR images before (D0), 1 day after (D1), and 3 days after (D3) IAS of 16 patients...
July 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28688717/detection-of-cardiac-iron-overload-with-native-magnetic-resonance-t1-and-t2-mapping-in-patients-with-thalassemia
#12
Rungroj Krittayaphong, Shuo Zhang, Pairash Saiviroonporn, Vip Viprakasit, Prajak Tanapibunpon, Chulaluk Komoltri, Wipaporn Wangworatrakul
BACKGROUND: To investigate the diagnostic performance of native cardiac magnetic resonance (CMR) T1 and T2 mapping for cardiac iron overload (CIO) in thalassemia patients. METHODS: All thalassemia patients who underwent CMR were enrolled on a clinical 1.5T scanner. Native T1 mapping with the Modified Look-Locker Inversion recovery (MOLLI) technique, T2 mapping using a black-blood multi-echo spin-echo technique, and conventional T2* mapping using multi-echo gradient-echo techniques were performed...
June 29, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28687810/full-left-ventricular-coverage-is-essential-for-the-accurate-quantification-of-the-area-at-risk-by-t1-and-t2-mapping
#13
Heerajnarain Bulluck, Jennifer A Bryant, Mei Xing Lim, Xiao Wei Tan, Manish Ramlall, Rohin Francis, Tushar Kotecha, Hector A Cabrera-Fuentes, Daniel S Knight, Marianna Fontana, James C Moon, Derek J Hausenloy
T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1 and T2 mapping and MI size. Forty-eight STEMI patients were prospectively recruited and underwent a CMR at 4 ± 2 days. There was no difference between the AARfull LV and AAR3-slices by T1 (P = 0...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687012/value-of-quantitative-magnetic-resonance-imaging-t1-relaxometry-in-predicting-contrast-enhancement-in-glioblastoma-patients
#14
Elke Hattingen, Andreas Müeller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, Sied Kebir
The repetitive usage of gadolinium-based contrast agents (GBCA) is critical for magnetic resonance imaging (MRI) evaluation of tumor burden in glioblastoma patients. It is also a crucial tool for determination of radiographical response to treatment. GBCA injection, however, comes with a 2.4% rate of adverse events including life-threatening conditions such as nephrogenic systemic fibrosis (NSF). Moreover, GBCA have been shown to be deposited in brain tissue of patients even with an intact blood-brain barrier (BBB)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28685430/influence-of-free-radicals-on-the-intrinsic-mri-relaxation-properties
#15
Rong-Wen Tain, Alessandro M Scotti, Weiguo Li, Xiaohong Joe Zhou, Kejia Cai
Free radicals are critical contributors in various conditions including normal aging, Alzheimer's disease, cancer, and diabetes. Currently there is no non-invasive approach to image tissue free radicals based on endogenous contrast due to their extremely short lifetimes and low in vivo concentrations. In this study we aim at characterizing the influence of free radicals on the MRI relaxation properties. Phantoms containing free radicals were created by treating egg white with various H 2 O 2 concentrations and scanned on a 9...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28679323/the-apparent-diffusion-coefficient-is-strongly-correlated-with-extracellular-volume-a-measure-of-myocardial-fibrosis-and-subclinical-cardiomyopathy-in-patients-with-systemic-lupus-erythematosus
#16
Rui Wu, Dong-Aolei An, Jiani Hu, Meng Jiang, Qiang Guo, Jian-Rong Xu, Lian-Ming Wu
Background Extracellular volume (ECV) has been histologically validated as a non-invasive quantitative index of myocardial fibrosis that does not require the use of contrast, which is contraindicated in patients with renal insufficiency. Purpose To evaluate the correlation between the contrast-free apparent diffusion coefficient (ADC) and ECV, an index of fibrosis. Material and Methods Twenty-four patients with systemic lupus erythematosus (SLE), who were predominantly women (mean age = 36 ± 12 years) and 12 normal participants (mean age = 38 ± 10 years) underwent cardiac magnetic resonance (CMR) via 3...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28678672/acute-versus-chronic-myocardial-infarction-diagnostic-accuracy-of-quantitative-native-t1-and-t2-mapping-versus-assessment-of-edema-on-standard-t2-weighted-cardiovascular-mr-images-for-differentiation
#17
Enver Tahir, Martin Sinn, Sebastian Bohnen, Maxim Avanesov, Dennis Säring, Christian Stehning, Bernhard Schnackenburg, Christine Eulenburg, Joshua Wien, Ulf K Radunski, Stefan Blankenberg, Gerhard Adam, Charles B Higgins, Maythem Saeed, Kai Muellerleile, Gunnar K Lund
Purpose To analyze the diagnostic accuracy of native T1 and T2 mapping compared with visual and quantitative assessment of edema on T2-weighted cardiac magnetic resonance (MR) images to differentiate between acute and chronic myocardial infarction. Materials and Methods This study had institutional ethics committee approval. Written informed consent was obtained from 67 consecutive patients (57 years ± 12; 78% men) with a first acute myocardial infarction, who were prospectively enrolled between April 2011 and June 2015...
July 3, 2017: Radiology
https://www.readbyqxmd.com/read/28677254/partial-volume-model-for-brain-mri-scan-using-mp2rage
#18
Quentin Duché, Hervé Saint-Jalmes, Oscar Acosta, Parnesh Raniga, Pierrick Bourgeat, Vincent Doré, Gary F Egan, Olivier Salvado
MP2RAGE is a T1 weighted MRI sequence that estimates a composite image providing much reduction of the receiver bias, has a high intensity dynamic range, and provides an estimate of T1 mapping. It is, therefore, an appealing option for brain morphometry studies. However, previous studies have reported a difference in cortical thickness computed from MP2RAGE compared with widely used Multi-Echo MPRAGE. In this article, we demonstrated that using standard segmentation and partial volume estimation techniques on MP2RAGE introduces systematic errors, and we proposed a new model to estimate partial volume of the cortical gray matter...
July 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28674263/pharmacological-profiles-of-a-highly-potent-and-long-acting-angiotensin-ii-receptor-antagonist-fimasartan-in-rats-and-dogs-after-oral-administration
#19
Soo Heui Paik, Yong Ha Chi, Joo Han Lee, Hee-Soo Han, Kyung-Tae Lee
The pharmacological profile of fimasartan, [2-n-butyl-5-dimethylamino-thiocarbonyl-methyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-pyrimidin-4(3H)-one, a new non-peptide angiotensin type 1 (AT1)-selective angiotensin receptor antagonist, has been investigated in a variety of in vitro and in vivo experimental models. In the present study, fimasartan showed slow dissociation and irreversible binding to AT1 subtype receptors in membrane fractions of HEK-293 cells with a Kd of 0.03 nM and a T1/2 of 63...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28674085/acute-infarct-extracellular-volume-mapping-to-quantify-myocardial-area-at-risk-and-chronic-infarct-size-on-cardiovascular-magnetic-resonance-imaging
#20
Pankaj Garg, David A Broadbent, Peter P Swoboda, James R J Foley, Graham J Fent, Tarique A Musa, David P Ripley, Bara Erhayiem, Laura E Dobson, Adam K McDiarmid, Philip Haaf, Ananth Kidambi, Rob J van der Geest, John P Greenwood, Sven Plein
BACKGROUND: Late gadolinium enhancement (LGE) imaging overestimates acute infarct size. The main aim of this study was to investigate whether acute extracellular volume (ECV) maps can reliably quantify myocardial area at risk (AAR) and final infarct size (IS). METHODS AND RESULTS: Fifty patients underwent cardiovascular magnetic resonance imaging acutely (24-72 hours) and at convalescence (3 months). The cardiovascular magnetic resonance protocol included cines, T2-weighted imaging, native T1 maps, 15-minute post-contrast T1 maps, and LGE...
July 2017: Circulation. Cardiovascular Imaging
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